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152. PARP Inhibitors in Endometrial Cancer: Current Status and Perspectives

Author

Musacchio, Lucia, Caruso, Giuseppe, Pisano, Carmela, Cecere, Sabrina Chiara, Di Napoli, Marilena, Attademo, Laura, Tambaro, Rosa, Russo, Daniela, Califano, Daniela, Palaia, Innocenza, Muzii, Ludovico, Benedetti Panici, Pierluigi, and Pignata, Sandro

Subjects
immune checkpoint inhibitors, homologous recombination deficiency, endometrial cancer, parp inhibitors, P53 mutation, PARP inhibitors, PTEN mutation, Review, pten mutation, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, p53 mutation
Abstract

Lucia Musacchio,1 Giuseppe Caruso,1 Carmela Pisano,2 Sabrina Chiara Cecere,2 Marilena Di Napoli,2 Laura Attademo,2 Rosa Tambaro,2 Daniela Russo,3 Daniela Califano,3 Innocenza Palaia,1 Ludovico Muzii,1 Pierluigi Benedetti Panici,1 Sandro Pignata2 1Department of Maternal and Child Health and Urological Sciences, University “Sapienza”, Policlinico Umberto I, Rome, Italy; 2Department of Urology and Gynecology, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Naples, Italy; 3Functional Genomic Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Naples, ItalyCorrespondence: Sandro PignataDepartment of Urology and Gynecology, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Semmola, Naples 80131, ItalyTel +39 0815903409Fax +39 0815903861Email s.pignata@istitutotumori.na.itAbstract: Advanced, recurrent and metastatic endometrial cancer (EC) has a dismal prognosis due to poor response rates to conventional treatments. In the era of precision medicine, the improved understanding of cancer genetics and molecular biology has led to the development of targeted therapies, such as poly (ADP-ribose) polymerase (PARP) inhibitors. This class of drugs that inhibit PARP enzymes has been investigated in many different types of tumors and its use in the treatment of gynecological malignancies has rapidly increased over the past few years. Data from several clinical trials showed that PARP inhibitors have a beneficial role in cancers with a defect in the homologous DNA recombination system, regardless of the BRCA mutational status. Since EC frequently shows mutations in PTEN and TP53 genes, indirectly involved in the homologous DNA recombination pathway, several in vivo and in vitro studies investigated the efficacy of PARP inhibitors in EC, showing promising results. This review will discuss the use of PARP inhibitors in endometrial cancer, summarizing data from preclinical studies and providing an overview of the ongoing trials, with a special focus on the development of combined treatment strategies with PARP inhibitors and immune checkpoint inhibitors.Keywords: endometrial cancer, PARP inhibitors, PTEN mutation, P53 mutation, homologous recombination deficiency, immune checkpoint inhibitors

Published
2020

154. FDMA Point-to-Multi-Point Fibre Access System for Latency Sensitive Applications

Author

Bluemm, Christian, Kirchbauer, Heinrich von, Caruso, Giuseppe, Leyva, Pablo, Wuensche, Ullrich, Huang, Rongfang, Wei, Jinlong, Cano, Ivan N., Calabrò, Stefano, and Talli, Giuseppe

Subjects
Optical fiber communication, High definition video, Frequency division multiaccess, Optical fibers, Point-to-multipoint communications, Protocols, Real-time systems
Published
2022

155. Steps to a Theory of Non-State Representation

Author

Caruso, Giuseppe, Teivainen, Teivo, Helsinki Inequality Initiative (INEQ), Centre of Excellence in Global Governance Research, The Global Extractivisms and Alternatives Initiative, Helsinki Hub on Emotions, Populism and Polarisation, Helsinki Institute of Sustainability Science (HELSUS), Political Science, and Faculty Common Matters (Faculty of Social Sciences)

Subjects
5200 Other social sciences, 5172 Global Politics
Published
2022

159. HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis

Author

Di Donato, Violante, primary, Caruso, Giuseppe, additional, Bogani, Giorgio, additional, Cavallari, Eugenio Nelson, additional, Palaia, Gaspare, additional, Perniola, Giorgia, additional, Ralli, Massimo, additional, Sorrenti, Sara, additional, Romeo, Umberto, additional, Pernazza, Angelina, additional, Pierangeli, Alessandra, additional, Clementi, Ilaria, additional, Mingoli, Andrea, additional, Cassoni, Andrea, additional, Tanzi, Federica, additional, Cuccu, Ilaria, additional, Recine, Nadia, additional, Mancino, Pasquale, additional, de Vincentiis, Marco, additional, Valentini, Valentino, additional, d’Ettorre, Gabriella, additional, Della Rocca, Carlo, additional, Mastroianni, Claudio Maria, additional, Antonelli, Guido, additional, Polimeni, Antonella, additional, Muzii, Ludovico, additional, and Palaia, Innocenza, additional

Published
2022
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164. Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer’s Disease

Author

Caruso, Giuseppe, primary, Grasso, Margherita, additional, Fidilio, Annamaria, additional, Torrisi, Sebastiano Alfio, additional, Musso, Nicolò, additional, Geraci, Federica, additional, Tropea, Maria Rosaria, additional, Privitera, Anna, additional, Tascedda, Fabio, additional, Puzzo, Daniela, additional, Salomone, Salvatore, additional, Drago, Filippo, additional, Leggio, Gian Marco, additional, and Caraci, Filippo, additional

Published
2021
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166. Pfizer-BioNTech COVID-19 Vaccine in Gynecologic Oncology Patients: A Prospective Cohort Study

Author

Palaia, Innocenza, primary, Caruso, Giuseppe, additional, Di Donato, Violante, additional, Vestri, Annarita, additional, Napoli, Anna, additional, Perniola, Giorgia, additional, Casinelli, Matteo, additional, Alunni Fegatelli, Danilo, additional, Campagna, Roberta, additional, Tomao, Federica, additional, D’Aniello, Debora, additional, Antonelli, Guido, additional, and Muzii, Ludovico, additional

Published
2021
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169. Development of an Icariin-Loaded Bilosome-Melittin Formulation with Improved Anticancer Activity against Cancerous Pancreatic Cells

Author

Alhakamy, Nabil A., primary, Badr-Eldin, Shaimaa M., additional, Alharbi, Waleed S., additional, Alfaleh, Mohamed A., additional, Al-hejaili, Omar D., additional, Aldawsari, Hibah M., additional, Eid, Basma G., additional, Bakhaidar, Rana, additional, Drago, Filippo, additional, Caraci, Filippo, additional, and Caruso, Giuseppe, additional

Published
2021
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175. Updates on Molecular and Biochemical Development and Progression of Prostate Cancer

Author

Fahmy, Omar, primary, Alhakamy, Nabil A., additional, Rizg, Waleed Y., additional, Bagalagel, Alaa, additional, Alamoudi, Abdulmohsin J., additional, Aldawsari, Hibah M., additional, Khateb, Aiah M., additional, Eldakhakhny, Basmah M., additional, Fahmy, Usama A., additional, Abdulaal, Wesam H., additional, Fresta, Claudia G., additional, and Caruso, Giuseppe, additional

Published
2021
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176. Ceftriaxone and Melittin Synergistically Promote Wound Healing in Diabetic Rats

Author

Alhakamy, Nabil A., primary, Caruso, Giuseppe, additional, Eid, Basma G., additional, Fahmy, Usama A., additional, Ahmed, Osama A. A., additional, Abdel-Naim, Ashraf B., additional, Alamoudi, Abdulmohsin J., additional, Alghamdi, Shareefa A., additional, Al Sadoun, Hadeel, additional, Eldakhakhny, Basmah M., additional, Caraci, Filippo, additional, and Abdulaal, Wesam H., additional

Published
2021
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177. The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling

Author

Fidilio, Annamaria, primary, Grasso, Margherita, additional, Turnaturi, Rita, additional, Caruso, Giuseppe, additional, Spitale, Federica Maria, additional, Vicario, Nunzio, additional, Parenti, Rosalba, additional, Spoto, Salvatore, additional, Musso, Nicolò, additional, Marrazzo, Agostino, additional, Chiechio, Santina, additional, Caraci, Filippo, additional, Pasquinucci, Lorella, additional, and Parenti, Carmela, additional

Published
2021
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178. Combined vesicouterine rupture during second-trimester medical abortion for fetal abnormality after prior cesarean delivery: A case report

Author

Caruso, Giuseppe, primary, Paladini, Vanessa, additional, D'ambrosio, Valentina, additional, Giancotti, Antonella, additional, Piccioni, Maria Grazia, additional, Palaia, Innocenza, additional, Di Donato, Violante, additional, Perniola, Giorgia, additional, Brunelli, Roberto, additional, Pecorini, Francesco, additional, Muzii, Ludovico, additional, and Scudo, Maria, additional

Published
2021
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180. Immigration and Adverse Pregnancy Outcomes in an Italian Free Care Hospital

Author

Caruso, Giuseppe, primary, Marcoccia, Eleonora, additional, Brunelli, Roberto, additional, Candelieri, Miriam, additional, Schiavi, Michele Carlo, additional, Zannini, Ilaria, additional, Perrone, Seila, additional, Capri, Oriana, additional, Muzii, Ludovico, additional, Perrone, Giuseppina, additional, and Galoppi, Paola, additional

Published
2021
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183. Early discharge after transfemoral transcatheter aortic valve implantation

Author

Barbanti, Marco, Capranzano, Piera, Ohno, Yohei, Attizzani, Guilherme F, Gulino, Simona, Immè, Sebastiano, Cannata, Stefano, Aruta, Patrizia, Bottari, Vera, Patanè, Martina, Tamburino, Claudia, Di Stefano, Daniele, Deste, Wanda, Giannazzo, Daniela, Gargiulo, Giuseppe, Caruso, Giuseppe, Sgroi, Carmelo, Todaro, Denise, Simone, Emanuela di, Capodanno, Davide, and Tamburino, Corrado

Published
2015
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189. Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization

Author

Lazzarino, Giacomo, primary, Pallisco, Romina, additional, Bilotta, Gabriele, additional, Listorti, Ilaria, additional, Mangione, Renata, additional, Saab, Miriam, additional, Caruso, Giuseppe, additional, Amorini, Angela, additional, Brundo, Maria, additional, Lazzarino, Giuseppe, additional, Tavazzi, Barbara, additional, and Bilotta, Pasquale, additional

Published
2021
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191. Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling

Author

Grasso, Margherita, primary, Caruso, Giuseppe, additional, Godos, Justyna, additional, Bonaccorso, Angela, additional, Carbone, Claudia, additional, Castellano, Sabrina, additional, Currenti, Walter, additional, Grosso, Giuseppe, additional, Musumeci, Teresa, additional, and Caraci, Filippo, additional

Published
2021
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194. Pulmonary metastasectomy in renal cell carcinoma: Predictive and prognostic elements from paired histopathological analysis of primary tumors and respective metastases

Author

Bersanelli, Melissa, primary, Buti, Sebastiano, additional, Gnetti, Letizia, additional, Varotti, Elena, additional, Carbognani, Paolo, additional, Rusca, Michele, additional, Leonardi, Francesco, additional, Campanini, Nicoletta, additional, Ziglioli, Francesco, additional, Dadomo, Clara Indira, additional, Pilato, Francesco Paolo, additional, Ventura, Luigi, additional, Braggio, Cesare, additional, Bocchialini, Giovanni, additional, Cortellini, Alessio, additional, Brunelli, Matteo, additional, Rapacchi, Elena, additional, Camisa, Roberta, additional, Caruso, Giuseppe, additional, Silini, Enrico Maria, additional, Maestroni, Umberto, additional, and Ampollini, Luca, additional

Published
2021
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195. sj-pdf-2-jnp-10.1177_23993693211028593 – Supplemental material for Pulmonary metastasectomy in renal cell carcinoma: Predictive and prognostic elements from paired histopathological analysis of primary tumors and respective metastases

Author

Bersanelli, Melissa, Buti, Sebastiano, Gnetti, Letizia, Varotti, Elena, Carbognani, Paolo, Rusca, Michele, Leonardi, Francesco, Campanini, Nicoletta, Ziglioli, Francesco, Dadomo, Clara Indira, Pilato, Francesco Paolo, Ventura, Luigi, Braggio, Cesare, Bocchialini, Giovanni, Cortellini, Alessio, Brunelli, Matteo, Rapacchi, Elena, Camisa, Roberta, Caruso, Giuseppe, Silini, Enrico Maria, Maestroni, Umberto, and Ampollini, Luca

Subjects
FOS: Clinical medicine, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-2-jnp-10.1177_23993693211028593 for Pulmonary metastasectomy in renal cell carcinoma: Predictive and prognostic elements from paired histopathological analysis of primary tumors and respective metastases by Melissa Bersanelli, Sebastiano Buti, Letizia Gnetti, Elena Varotti, Paolo Carbognani, Michele Rusca, Francesco Leonardi, Nicoletta Campanini, Francesco Ziglioli, Clara Indira Dadomo, Francesco Paolo Pilato, Luigi Ventura, Cesare Braggio, Giovanni Bocchialini, Alessio Cortellini, Matteo Brunelli, Elena Rapacchi, Roberta Camisa, Giuseppe Caruso, Enrico Maria Silini, Umberto Maestroni and Luca Ampollini in Journal of Onco-Nephrology

Published
2021
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196. sj-pdf-1-jnp-10.1177_23993693211028593 – Supplemental material for Pulmonary metastasectomy in renal cell carcinoma: Predictive and prognostic elements from paired histopathological analysis of primary tumors and respective metastases

Author

Bersanelli, Melissa, Buti, Sebastiano, Gnetti, Letizia, Varotti, Elena, Carbognani, Paolo, Rusca, Michele, Leonardi, Francesco, Campanini, Nicoletta, Ziglioli, Francesco, Dadomo, Clara Indira, Pilato, Francesco Paolo, Ventura, Luigi, Braggio, Cesare, Bocchialini, Giovanni, Cortellini, Alessio, Brunelli, Matteo, Rapacchi, Elena, Camisa, Roberta, Caruso, Giuseppe, Silini, Enrico Maria, Maestroni, Umberto, and Ampollini, Luca

Subjects
FOS: Clinical medicine, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-jnp-10.1177_23993693211028593 for Pulmonary metastasectomy in renal cell carcinoma: Predictive and prognostic elements from paired histopathological analysis of primary tumors and respective metastases by Melissa Bersanelli, Sebastiano Buti, Letizia Gnetti, Elena Varotti, Paolo Carbognani, Michele Rusca, Francesco Leonardi, Nicoletta Campanini, Francesco Ziglioli, Clara Indira Dadomo, Francesco Paolo Pilato, Luigi Ventura, Cesare Braggio, Giovanni Bocchialini, Alessio Cortellini, Matteo Brunelli, Elena Rapacchi, Roberta Camisa, Giuseppe Caruso, Enrico Maria Silini, Umberto Maestroni and Luca Ampollini in Journal of Onco-Nephrology

Published
2021
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197. MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints

Author

Vergallo, Andrea, Lista, Simone, group, INSIGHT-preAD study, Lucía, Alejandro, Mango, Dalila, Mapstone, Mark, Neri, Christian, Nisticò, Robert, O'Bryant, Sid E, Palermo, Giovanni, Perry, George, Ritchie, Craig, Rossi, Simone, Initiative, Alzheimer Precision Medicine, Saidi, Amira, Santarnecchi, Emiliano, Schneider, Lon S, Sporns, Olaf, Toschi, Nicola, Valenzuela, Pedro L, Vellas, Bruno, Verdooner, Steven R, Villain, Nicolas, Giudici, Kelly Virecoulon, Bakardjian, Hovagim, Watling, Mark, Welikovitch, Lindsay A, Woodcock, Janet, Younesi, Erfan, Zugaza, José L, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Boukerrou, Nadia, Cavedo, Enrica, Chiesa, Patrizia, Zhao, Yuhai, Colliot, Olivier, Dubois, Bruno, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Habert, Marie-Odile, Hampel, Harald, Houot, Marion, Kas, Aurélie, Lemercier, Pablo, Lamari, Foudil, Levy, Marcel, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Potier, Marie-Claude, Revillon, Marie, Santos, Antonio, Teipel, Stefan J, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, de Schotten, Michel Thiebaut, Younsi, Nadjia, Afshar, Mohammad, Aguilar, Lisi Flores, Akman-Anderson, Leyla, Arenas, Joaquín, Ávila, Jesús, Babiloni, Claudio, Baldacci, Filippo, Batrla, Richard, Benda, Norbert, Black, Keith L, Bokde, Arun L W, Bonuccelli, Ubaldo, Broich, Karl, Cacciola, Francesco, Caraci, Filippo, Caruso, Giuseppe, Castrillo, Juan, Ceravolo, Roberto, Chiesa, Patrizia A, Corbo, Massimo, Corvol, Jean-Christophe, Cuello, Augusto Claudio, Cummings, Jeffrey L, Depypere, Herman, Duggento, Andrea, Emanuele, Enzo, Escott-Price, Valentina, Federoff, Howard, Ferretti, Maria Teresa, Fiandaca, Massimo, Frank, Richard A, Garaci, Francesco, Lukiw, Walter J, Geerts, Hugo, Giacobini, Ezio, Giorgi, Filippo S, Goetzl, Edward J, Graziani, Manuela, Haberkamp, Marion, Hänisch, Britta, Herholz, Karl, Hernandez, Felix, Imbimbo, Bruno P, Kapogiannis, Dimitrios, Karran, Eric, Kiddle, Steven J, Kim, Seung H, Koronyo, Yosef, Koronyo-Hamaoui, Maya, Langevin, Todd, Lehéricy, Stéphane, Llavero, Francisco, Lorenceau, Jean, Ministre de l'Enseignement Supérieur, de la Recherche et de l'Innovation (France), Sorbonne Université, AXA Research Fund, Fondation partenariale, Fondation pour la Recherche sur Alzheimer, Investissement d’Avenir French program, Vergallo, Andrea [0000-0002-0208-6384], Apollo - University of Cambridge Repository, Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 AMP), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de la Mémoire et de la Maladie d'Alzheimer [Paris] (IM2A), Sorbonne Université (SU), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Louisiana State University (LSU), University of Rostock, Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CATI Multicenter Neuroimaging Platform (CATI), Service de médecine nucléaire [CHU Pitié-Salpétrière], Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Department of Psychiatry, Psychosomatic Medicine and Psychotherapy [Goethe Universität], Goethe-Universität Frankfurt am Main, HAL-SU, Gestionnaire, Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 APM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre] (IM2A), Service de Médecine nucléaire [CHU Pitié-Salpétrière], Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France, Groupe de recherche clinique Alzheimer Precision Medicine (GRC 21 - APM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire d'Imagerie Biomédicale [Paris] (LIB), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)

Subjects
Apolipoprotein E, Aging, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Disease, miRNAs plasma concentrations, Alzheimer's Disease, amyloid-β (Aβ)-positron emission tomography (Aβ-PET), Prognostic markers, 0302 clinical medicine, Medicine, Psychology, Aetiology, education.field_of_study, MicroARNs, Settore FIS/07, amyloid, Brain, Pathophysiology, ALZHEIMERS-DISEASE, Psychiatry and Mental health, Alzheimer's disease (AD), Public Health and Health Services, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], MiRNA, medicine.medical_specialty, 18F-fluorodeoxyglucose-PET (18F-FDG-PET), BIOMARKERS, Neurociencias, Clinical Sciences, Molecular neuroscience, Predictive markers, Article, VESICLES, lcsh:RC321-571, 03 medical and health sciences, Memory, Clinical Research, Alzheimer Disease, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], microRNA, Genetics, Humans, education, Biological Psychiatry, Prevention, Memory, MiRNA, Alzheimer, biological markers, amyloid, 030104 developmental biology, Endocrinology, Cross-Sectional Studies, Positron-Emission Tomography, CELLS, Dementia, diagnostic imaging [Alzheimer Disease], INSIGHT-preAD study group, 030217 neurology & neurosurgery, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, 0301 basic medicine, genetics [Alzheimer Disease], Pilot Projects, Neurodegenerative, Medicine and Health Sciences, 2.1 Biological and endogenous factors, genetics [MicroRNAs], MIR-125B, screening and diagnosis, PLASMA, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Detection, Real-time polymerase chain reaction, Neurological, medicine.symptom, biological markers, Biotechnology, EXPRESSION, Population, metabolism [Amyloid beta-Peptides], Asymptomatic, Salud mental, Cellular and Molecular Neuroscience, ADULT, Fluorodeoxyglucose F18, Internal medicine, Acquired Cognitive Impairment, ddc:610, Allele, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, diagnostic imaging [Brain], Psiquiatría, Amyloid beta-Peptides, Enfermedad de alzheimer, business.industry, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Neurosciences, Alzheimer Precision Medicine Initiative, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, 4.1 Discovery and preclinical testing of markers and technologies, MicroRNAs, metabolism [Brain], Alzheimer, business, Psychiatric disorders
Abstract

There is substantial experimental evidence for dysregulation of several microRNA (miRNA) expression levels in Alzheimer’s disease (AD). MiRNAs modulate critical brain intracellular signaling pathways and are associated with AD core pathophysiological mechanisms. First, we conducted a real-time quantitative PCR-based pilot study to identify a set of brain-enriched miRNAs in a monocentric cohort of cognitively normal individuals with subjective memory complaints, a condition associated with increased risk of AD. Second, we investigated the impact of age, sex, and the Apolipoprotein E ε4 (APOE ε4) allele, on the identified miRNA plasma concentrations. In addition, we explored the cross-sectional and longitudinal association of the miRNAs plasma concentrations with regional brain metabolic uptake using amyloid-β (Aβ)-positron emission tomography (Aβ-PET) and F-fluorodeoxyglucose-PET (F-FDG-PET). We identified a set of six brain-enriched miRNAs—miRNA-125b, miRNA-146a, miRNA-15b, miRNA-148a, miRNA-26b, and miRNA-100. Age, sex, and APOE ε4 allele were not associated with individual miRNA abundance. MiRNA-15b concentrations were significantly lower in the Aβ-PET-positive compared to Aβ-PET-negative individuals. Furthermore, we found a positive effect of the miRNA-15b*time interaction on regional metabolic F-FDG-PET uptake in the left hippocampus. Plasma miRNA-125b concentrations, as well as the miRNA-125b*time interaction (over a 2-year follow-up), were negatively associated with regional Aβ-PET standard uptake value ratio in the right anterior cingulate cortex. At baseline, we found a significantly negative association between plasma miRNA-125b concentrations and F-FDG-PET uptake in specific brain regions. In an asymptomatic at-risk population for AD, we show significant associations between plasma concentrations of miRNA-125b and miRNA-15b with core neuroimaging biomarkers of AD pathophysiology. Our results, coupled with existing experimental evidence, suggest a potential protective anti-Aβ effect of miRNA-15b and a biological link between miRNA-125b and Aβ-independent neurotoxic pathways., “Investissement d’Avenir” (ANR-10-AIHU-06) French program. The study was promoted in collaboration with the “CHU de Bordeaux” (coordination CIC EC7), the promoter of Memento cohort, funded by the Foundation Plan-Alzheimer. The study was further supported by AVID/Lilly. CATI is a French neuroimaging platform funded by the French Plan Alzheimer (available at http://cati-neuroimaging.com). A.V. is an employee of Eisai Inc. This work has been performed during his previous position at Sorbonne University, Paris, France. H.H. is an employee of Eisai Inc. This work has been performed during his previous position at Sorbonne University, Paris, France. At Sorbonne University he was supported by the AXA Research Fund, the “Fondation partenariale Sorbonne Université” and the “Fondation pour la Recherche sur Alzheimer

Published
2021

198. Updates on molecular and biochemical development and progression of prostate cancer

Author

Fahmy, Omar, A. Alhakamy, Nabil, Y. Rizg, Waleed, Bagalagel, Alaa, J. Alamoudi, Abdulmohsin, M. Aldawsari, Hibah, M. Khateb, Aiah, M. Eldakhakhny, Basmah, A. Fahmy, Usama, H. Abdulaal, Wesam, G. Fresta, Claudia, Caruso, Giuseppe, Fahmy, Omar, A. Alhakamy, Nabil, Y. Rizg, Waleed, Bagalagel, Alaa, J. Alamoudi, Abdulmohsin, M. Aldawsari, Hibah, M. Khateb, Aiah, M. Eldakhakhny, Basmah, A. Fahmy, Usama, H. Abdulaal, Wesam, G. Fresta, Claudia, and Caruso, Giuseppe

Abstract

Prostate cancer (PCa) represents the most commonly non-cutaneous diagnosed cancer in men worldwide and occupies a very wide area of preclinical and clinical research. Targeted therapy for any cancer depends on the understanding of the molecular bases and natural behaviour of the diseases. Despite the well-known effect of androgen deprivation on PCa, many patients develop resistance either for antiandrogen therapy or other new treatment modalities such as checkpoint inhibitors and chemotherapy. Comprehensive understanding of the development of PCa as well as of the mechanisms underlying its progression is mandatory to maximise the benefit of the current approved medications or to guide the future research for targeted therapy of PCa. The aim of this review was to provide updates on the most recent mechanisms regarding the development and the progression of PCa. According to the current understanding, future treatment strategies should include more predictive genetic and biomarker analysis to assign different patients to the expected most appropriate and effective treatment.

Published
2021

199. Immigration and Adverse Pregnancy Outcomes in an Italian Free Care Hospital

Author

Caruso,Giuseppe, Marcoccia,Eleonora, Brunelli,Roberto, Candelieri,Miriam, Schiavi,Michele Carlo, Zannini,Ilaria, Perrone,Seila, Capri,Oriana, Muzii,Ludovico, Perrone,Giuseppina, Galoppi,Paola, Caruso,Giuseppe, Marcoccia,Eleonora, Brunelli,Roberto, Candelieri,Miriam, Schiavi,Michele Carlo, Zannini,Ilaria, Perrone,Seila, Capri,Oriana, Muzii,Ludovico, Perrone,Giuseppina, and Galoppi,Paola

Abstract

Giuseppe Caruso,1 Eleonora Marcoccia,1,2 Roberto Brunelli,1 Miriam Candelieri,1 Michele Carlo Schiavi,1 Ilaria Zannini,1 Seila Perrone,1 Oriana Capri,1 Ludovico Muzii,1 Giuseppina Perrone,1 Paola Galoppi1 1Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Umberto I Hospital, Rome, Italy; 2Department of Experimental Medicine, Sapienza University of Rome, Umberto I Hospital, Rome, ItalyCorrespondence: Giuseppe CarusoDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Umberto I Hospital, Viale del Policlinico, 155, Rome, 00161, ItalyTel +39064463069; +390649972568Email g.caruso@uniroma1.itIntroduction: The ever-increasing wave of immigration in Italy has posed demanding challenges in the management of the new multiethnic obstetric population. The aim of this study was to compare pregnancy and perinatal outcomes between immigrants and the native population in an Italian public hospital.Materials and Methods: Singleton pregnant women (≥ 24 weeks of gestation) who delivered during a 3-year period in an Italian free care hospital were included. Long-term (≥ 2 years of residence) immigrant patients were divided into 4 groups according to their ethnic origin: Europeans, Asians, Latin Americans, and Africans. Perinatal indicators of obstetric outcomes were collected and compared between immigrants and Italians.Results: Of the 3556 patients included, 1092 were immigrants and 2464 Italians. The immigrant cohort experienced a higher rate of macrosomia (1.8% vs 0.6%; p = 0.001), very low birth weight (1.3% vs 0.6%; p = 0.048), very early preterm delivery (1.4% vs 0.4%; p = 0.048), and gestational diabetes mellitus (1.8% vs 0.5%; p = 003) compared with the native population. The overall rate of cesarean sections was greater among Italians (56% vs 45.8%; p < 0.001). Among ethnic groups, Europeans and Latin Americans reported a higher rate of preterm delivery (20.2% and 19%, respectively; p

Published
2021

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