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151. Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties

Author

Alexia Blandin, Jérémy Amosse, Josy Froger, Grégory Hilairet, Maëva Durcin, Lionel Fizanne, Valentine Ghesquière, Xavier Prieur, Julien Chaigneau, Luisa Vergori, Cédric Dray, Jean-Philippe Pradère, Stéphanie Blandin, Joëlle Dupont, Pierre-Henri Ducluzeau, Séverine Dubois, Jérôme Boursier, Bertrand Cariou, and Soazig Le Lay

Subjects
CP: Metabolism, Biology (General), QH301-705.5
Abstract

Summary: Recent evidence supporting that adipose tissue (AT)-derived extracellular vesicles (EVs) carry an important part of the AT secretome led us to characterize the EV-adipokine profile. In addition to evidencing a high AT-derived EV secretion ability that is further increased by obesity, we identify enrichment of oligomeric forms of adiponectin in small EVs (sEVs). This adipokine is mainly distributed at the EV external surface as a result of nonspecific adsorption of soluble adiponectin. EVs also constitute stable conveyors of adiponectin in the blood circulation. Adiponectin-enriched sEVs display in vitro insulin-sensitizing effects by binding to regular adiponectin receptors. Adoptive transfer of adiponectin-enriched sEVs in high-fat-diet-fed mice prevents animals from gaining weight and ameliorated insulin resistance and tissue inflammation, with major effects observed in the AT and liver. Our results therefore provide information regarding adiponectin-related metabolic responses by highlighting EVs as delivery platforms of metabolically active forms of adiponectin molecules.

Published
2023
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152. The epigenetic hallmark of early-life α-hexabromocyclododecane exposure: From cerebellar 6-mA levels to locomotor performance in adulthood

Author

Cyrielle Holuka, Chloé Morel, Sarah Roth, Yordenca Lamartinière, Sophie B. Mériaux, Justine Paoli, Pauline Guébels, Radu C. Duca, Lode Godderis, An van Nieuwenhuyse, Pascaline Kremarik-Bouillaud, Ronan Cariou, Claude Emond, Henri Schroeder, Jonathan D. Turner, and Nathalie Grova

Subjects
α-hexabromocyclododecane, Early-life exposure, 6 methyl-adenine, Cerebellum, Developmental neurotoxicity, Rat, Environmental sciences, GE1-350
Abstract

There is a growing evidence that methylation at the N6 position of adenine (6-mA), whose modulation occurs primarily during development, would be a reliable epigenetic marker in eukaryotic organisms. The present study raises the question as to whether early-life exposure to α-hexabromocyclododecane (α-HBCDD), a brominated flame retardant, may trigger modifications in 6-mA epigenetic hallmarks in the brain during the development which, in turn could affect the offspring behaviour in adulthood. Pregnant Wistar rats were split into two groups: control and α-HBCDD (66 ng/kg/per os, G0-PND14). At PND1, α-HBCDD levels were assessed in brain and liver by LC-MS/MS. At PND14, DNA was isolated from the offspring’s cerebellum. DNA methylation was measured by 6-mA-specific immunoprecipitation and Illumina® sequencing (MEDIP-Seq). Locomotor activity was finally evaluated at PND120. In our early-life exposure model, we confirmed that α-HBCDD can cross the placental barrier and be detected in pups at birth. An obvious post-exposure phenotype with locomotor deficits was observed when the rats reached adulthood. This was accompanied by sex-specific over-methylation of genes involved in the insulin signaling pathway, MAPK signaling pathway as well as serotonergic and GABAergic synapses, potentially altering the normal process of neurodevelopment with consequent motor impairments crystalized at adulthood.

Published
2023
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153. PupillOmetry for preDIction of DeliriUM in ICU (PODIUM): protocol for a prospective multicentre cohort study

Author

Emmanuel Guerot, Bertrand Hermann, Stéphane Gaudry, Jean-François Timsit, Maxens Decavèle, Alain Combes, Jean-Paul Mira, Benjamin Assouline, Alexandre Demoule, Muriel Fartoukh, Romain Sonneville, Lila Bouadma, Yves Cohen, Guillaume Voiriot, Camille Couffignal, Etienne De Montmollin, Jean-Luc Diehl, Pierre Jaquet, Coralie Tardivon, Sarah Benghanem, Thomas Rambaud, Virginie Godard, Romane Bellot, Daniel Da Silva, Julien Dessajan, Michael Thy, Marc Doman, Hermann Do Rego, Michael Ejzenberg, Erwann Cariou, Simona Presente, Paul-Henri Wicky, Mario Rienzo, Mariem Dlela, Fariza Lamara, Nathalie Marin, Juliette Pelle, Stephanie Cossec, Smina Hadj Mahfoud, Tchoubou Tona, Khalil Chaibi, Eleonore Bouchereau, Antoine Troger, Julie Langlais, Nicolas Peron, Caroline Hauw-Berlemont, and Nicolas Brechot

Subjects
Medicine
Abstract

Introduction Delirium is a severe complication that is associated with short-term adverse events, prolonged hospital stay and neurological sequelae in survivors. Automated pupillometry is an easy-to-use device that allows for accurate objective assessment of the pupillary light responses in comatose patients in the intensive care unit (ICU). Whether automated pupillometry might predict delirium in critically ill patients is not known. We hypothesise that automated pupillometry could predict the occurrence of delirium in critically ill patients without primary brain injury, requiring more than 48 hours of invasive mechanical ventilation in the ICU.Methods and analysis The PupillOmetry for preDIction of DeliriUM in ICU (PODIUM) study is a prospective cohort study, which will be conducted in eight French ICUs in the Paris area. We aim to recruit 213 adult patients requiring invasive mechanical ventilation for more than 48 hours. Automated pupillometry (Neurological Pupil Index; NPi-200, Neuroptics) will be assessed two times per day for 7 days. Delirium will be assessed using the Confusion Assessment Method in ICU two times per day over 14 days in non-comatose patients (Richmond Agitation and Sedation Scale ≥−3).The predictive performances of the seven automated pupillometry parameters (ie, pupillary diameter, variation of the pupillary diameter, pupillary constriction speed, pupillary dilatation speed, photomotor reflex latency, NPi and symmetry of pupillary responses) measured to detect the delirium occurrence within 14 days will be the main outcomes. Secondary outcomes will be the predictive performances of the seven automated pupillometry parameters to detect complications related to delirium, ICU length of stay, mortality, functional and cognitive outcomes at 90 days.Ethics and dissemination The PODIUM study has been approved by an independent ethics committee, the Comité de Protection des Personnes (CPP) OUEST IV—NANTES (CPP21.02.15.45239 32/21_3) on 06 April 2021). Participant recruitment started on 15 April 2022. Results will be published in international peer-reviewed medical journals and presented at conferences.Trial registration number NCT05248035; clinicaltrials.gov.

Published
2023
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154. TransFAIR study: a European multicentre experimental comparison of EHR2EDC technology to the usual manual method for eCRF data collection

Author

Gilles Chatellier, Oriana Nanni, Christel Daniel, Nicolas Griffon, Mats Sundgren, Nadir Ammour, Juliette Djadi-Prat, Martine Lewi, Marija Todorovic, Augustín Gómez de la Cámara, Maria Teresa García Morales, Sara Testoni, Christoph Schindler, Almenia Garvey, Tomothy Victor, and Manon Cariou

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Purpose Regulatory authorities including the Food and Drug Administration and the European Medicines Agency are encouraging to conduct clinical trials using routinely collected data. The aim of the TransFAIR experimental comparison was to evaluate, within real-life conditions, the ability of the Electronic Health Records to Electronic Data Capture (EHR2EDC) module to accurately transfer from EHRs to EDC systems patients’ data of clinical studies in various therapeutic areas.Methods A prospective study including six clinical trials from three different sponsors running in three hospitals across Europe has been conducted. The same data from the six studies were collected using both traditional manual data entry and the EHR2EDC module. The outcome variable was the percentage of data accurately transferred using the EHR2EDC technology. This percentage was calculated considering all collected data and the data in four domains: demographics (DM), vital signs (VS), laboratories (LB) and concomitant medications (CM).Results Overall, 6143 data points (39.6% of the data in the scope of the TransFAIR study and 16.9% when considering all data) were accurately transferred using the platform. LB data represented 65.4% of the data transferred; VS data, 30.8%; DM data, 0.7% and CM data, 3.1%.Conclusions The objective of accurately transferring at least 15% of the manually entered trial datapoints using the EHR2EDC module was achieved. Collaboration and codesign by hospitals, industry, technology company, supported by the Institute of Innovation through Health Data was a success factor in accomplishing these results. Further work should focus on the harmonisation of data standards and improved interoperability to extend the scope of transferable EHR data.

Published
2023
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155. Generation, characterisation and identification of bioactive peptides from Mesopelagic fish protein hydrolysates using in silico and in vitro approaches.

Author

Hayes, Maria, primary, Naik, Azza Silotry, additional, Mora, Leticia, additional, Iñarra, Bruno, additional, Ibarruri, Jone, additional, Bald, Carlos, additional, Cariou, Thibault, additional, Reid, David G., additional, Gallagher, Michael, additional, Dragoy, Ragnhild, additional, Galino, Jorge, additional, Deya, Alba, additional, Albrektsen, Sissel, additional, Thoresen, Lars, additional, and Solstad, Runar Gjerp, additional

Published
2024
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156. WED-194 Diagnostic performance of non-invasive tests and comparison of AGA and EASL algorithm for the screening of MASLD-related advanced fibrosis in diabetes and nutrition clinics

Author

Caussy, Cyrielle, primary, Vergès, Bruno, additional, Damien, Leleu, additional, Laurence, Duvillard, additional, Amna, Abichou-Klich, additional, Hervieu, Valerie, additional, Ségrestin, Bérénice, additional, Sylvie, Bin, additional, Alexia, Rouland, additional, Delaunay, Dominique, additional, Samy, Hadjadj, additional, Claire, Primot, additional, Petit, Jean-Michel, additional, Charrière, Sybil, additional, Moulin, Philippe, additional, Levrero, Massimo, additional, Cariou, Bertrand, additional, and Disse, Emmanuel, additional

Published
2024
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157. LBP-032 Semaglutide improves cardiovascular outcomes in patients with high risk for metabolic dysfunction-associated steatohepatitis-a subgroup analysis from the SELECT trial

Author

Meyhöfer, Sebastian, primary, Cariou, Bertrand, additional, Cercato, Cintia, additional, Colhoun, Helen, additional, Duun-Henriksen, Anne, additional, Kliers, Iris, additional, Lincoff, A. Michael, additional, Lingvay, Ildiko, additional, Long, Michelle, additional, Newsome, Philip N., additional, Nicholls, Stephen, additional, De Los Angeles Quiroga Pelaez, Maria, additional, Santini, Ferruccio, additional, Sanyal, Arun J., additional, and Kahn, Steven, additional

Published
2024
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158. Results of the George Washington University cancer center’s comprehensive cancer control cancer communication mentorship program and implications for future practice

Author

Duong, Dao, Agraviador, Danielle, Cariou, Charlene, George, Maria, Karanja, Miriam, Kashima, Kanako, Kerch, Sarah, Khalaf, Mohammad, Love, Brad, McCauley-Hixenbaugh, Lauren, Phillips, Serena, Ramirez, Susana, Sy, Angela, Tutii, Irish, Van Kirk Villalobos, Aubrey, and Pratt-Chapman, Mandi L.

Published
2022
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162. Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry

Author

Aghel, Nazanin, Alexandre, Joachim, Aonuma, Kazutaka, Asnani, Aarti H., Behling, Juliane, Bilen, Mehmet, Bottinor, Wendy, Cariou, Eve, Chahine, Johnny, Chan, Weiting, Chauhan, Aman, Cohen, Max, Crusz, Shanthini, Fernando, Suran, Florido, Roberta, Frigeri, Mauro, Fukushima, Satoshi, Gaughan, Elizabeth, Geisler, Benjamin P., Gilstrap, Lauren, Grohe, Christian, Guha, Avirup, Habib, Manhal, Haegler-Laube, Eva, Haydon, Andrew, Hayek, Salim, Hughes, Andrew, Imai, Rysk, Katsume, Yumi, Kimura, Hideki, Koo Lin, Lily, Lenneman, Carrie, Leong, Daryl, Makker, Vicky, Martinez-Calle, Nicolas, Moey, Melissa, Mohri, Masahiro, Morimoto, Ryota, Moritoki, Yoshinobu, Narezkina, Anna, Nicol, Martin, Nooka, Ajay, Orimoloye, Olusola, Patel, Milan, Perl, Michal, Piriou, Nicolas, Raikhelkar, Jayant K., Raza, Yasmin, Rao, Anjali, Reddy, Sunil, Seki, Nobuhiko, Stangl, Karl, Stewart, Andrew, Stringer, Bryan, Tamarappoo, Balaji K., Tamura, Yuichi, Thuny, Frank, Tierney, Sean, Tresorier, Romain, Ullah, Waqas, Von Hunolstein, Jean-Jacques, Warner, Ellen, Weppler, Allison, Nowatzke, Joseph, Guedeney, Paul, Palaskas, Nicholas, Lehmann, Lorenz, Ederhy, Stephane, Zhu, Han, Cautela, Jennifer, Francis, Sanjeev, Courand, Pierre-Yves, Deswal, Anita, Ewer, Steven M., Aras, Mandar, Arangalage, Dimitri, Ghafourian, Kambiz, Fenioux, Charlotte, Finke, Daniel, Peretto, Giovanni, Zaha, Vlad, Itzhaki Ben Zadok, Osnat, Tajiri, Kazuko, Akhter, Nausheen, Levenson, Joshua, Baldassarre, Lauren, Power, John, Huang, Shi, Collet, Jean-Philippe, Moslehi, Javid, and Salem, Joe-Elie

Published
2022
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163. Burden of cardiovascular disease in a large contemporary cohort of patients with heterozygous familial hypercholesterolemia

Author

Angoulvant, Denis, Aouchiche, Karine, Beliard, Sophie, Boccara, Franck, Bruckert, Eric, Cariou, Bertrand, Carreau, Valérie, Carrie, Alain, Charrieres, Sybil, Cottin, Yves, Di Filippo, Mathilde, Dourmap, Caroline, Ducluzeau, Pierre-Henri, Durlach, Vincent, Farnier, Michel, Ferrari, Emile, Ferrieres, Dorota, Ferrieres, Jean, Gallo, Antonio, Hankard, Regis, Inamo, Jocelyn, Kalmykova, Olga, Krempf, Michel, Lemale, Julie, Moulin, Philippe, Paillard, François, Peretti, Noel, Perrin, Agnes, Pradignac, Alain, Pucheu, Yann, Rabes, Jean Pierre, Reynaud, Rachel, Rigalleau, Vincent, Schiele, François, Sultan, Ariane, Tounian, Patrick, Valero, René, Verges, Bruno, Yelnik, Cecile, Ziegler, Olivier, Ferrières, Jean, Vimont, Alexandre, Ferrières, Dorota, and Béliard, Sophie

Published
2022
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168. Sotagliflozin Added to Optimized Insulin Therapy Leads to Lower Rates of Clinically Relevant Hypoglycemic Events at Any HbA1c at 52 Weeks in Adults with Type 1 Diabetes

Author

Danne, Thomas, Pettus, Jeremy, Giaccari, Andrea, Cariou, Bertrand, Rodbard, Helena, Weinzimer, Stuart A, Bonnemaire, Mireille, Sawhney, Sangeeta, Stewart, John, Wang, Stella, de Cassia Castro, Rita, and Garg, Satish K

Subjects
Clinical Trials and Supportive Activities, Autoimmune Disease, Diabetes, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Metabolic and endocrine, Adult, Blood Glucose, Diabetes Mellitus, Type 1, Double-Blind Method, Drug Therapy, Combination, Female, Glycated Hemoglobin A, Glycosides, Humans, Hypoglycemia, Hypoglycemic Agents, Insulin, Male, Middle Aged, Sodium-Glucose Transporter 2 Inhibitors, Treatment Outcome, Glycated Hemoglobin, Efficacy beyond HbA1c, HbA1c, SGLT1/SGLT2 inhibitors, Sotagliflozin, inTandem, Clinical Sciences, Medical Physiology, Endocrinology & Metabolism
Abstract

Background: Hypoglycemia rates usually increase when insulin treatment is intensified to improve glycemic control. We evaluated (post hoc) hypoglycemic rates in adult patients with type 1 diabetes (T1D) on sotagliflozin (a dual sodium-glucose cotransporter [SGLT] 1 and 2 inhibitor) in two phase 3, 52-week clinical trials (inTandem 1 and 2; NCT02384941 and NCT02421510). Materials and Methods: We analyzed rates of documented hypoglycemia (level 1, blood glucose ≥54 to

Published
2019

169. International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium–Glucose Cotransporter (SGLT) Inhibitors

Author

Danne, Thomas, Garg, Satish, Peters, Anne L, Buse, John B, Mathieu, Chantal, Pettus, Jeremy H, Alexander, Charles M, Battelino, Tadej, Ampudia-Blasco, F Javier, Bode, Bruce W, Cariou, Bertrand, Close, Kelly L, Dandona, Paresh, Dutta, Sanjoy, Ferrannini, Ele, Fourlanos, Spiros, Grunberger, George, Heller, Simon R, Henry, Robert R, Kurian, Martin J, Kushner, Jake A, Oron, Tal, Parkin, Christopher G, Pieber, Thomas R, Rodbard, Helena W, Schatz, Desmond, Skyler, Jay S, Tamborlane, William V, Yokote, Koutaro, and Phillip, Moshe

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Obesity, Diabetes, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Metabolic and endocrine, Good Health and Well Being, Consensus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Ketoacidosis, Glucose, Humans, Hypoglycemic Agents, Risk Management, Sodium, Sodium-Glucose Transporter 2 Inhibitors, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences, Health sciences
Abstract

Sodium-glucose cotransporter (SGLT) inhibitors are new oral antidiabetes medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure, and body weight without intrinsic properties to cause hypoglycemia in people with type 1 diabetes. However, recent studies, particularly in individuals with type 1 diabetes, have demonstrated increases in the absolute risk of diabetic ketoacidosis (DKA). Some cases presented with near-normal blood glucose levels or mild hyperglycemia, complicating the recognition/diagnosis of DKA and potentially delaying treatment. Several SGLT inhibitors are currently under review by the U.S. Food and Drug Administration and European regulatory agencies as adjuncts to insulin therapy in people with type 1 diabetes. Strategies must be developed and disseminated to the medical community to mitigate the associated DKA risk. This Consensus Report reviews current data regarding SGLT inhibitor use and provides recommendations to enhance the safety of SGLT inhibitors in people with type 1 diabetes.

Published
2019

170. Organ donation after out-of-hospital cardiac arrest: a population-based study of data from the Paris Sudden Death Expertise Center

Author

M. Renaudier, Y. Binois, F. Dumas, L. Lamhaut, F. Beganton, D. Jost, J. Charpentier, O. Lesieur, E. Marijon, X. Jouven, A. Cariou, W. Bougouin, and Paris Sudden Death Expertise Center group

Subjects
Out-of-hospital cardiac arrest, Epidemiology, Organ donation, Brain death, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Organ shortage is a major public health issue, and patients who die after out-of-hospital cardiac arrest (OHCA) could be a valuable source of organs. Here, our objective was to identify factors associated with organ donation after brain death complicating OHCA, in unselected patients entered into a comprehensive real-life registry covering a well-defined geographic area. Methods We prospectively analyzed consecutive adults with OHCA who were successfully resuscitated, but died in intensive care units in the Paris region in 2011–2018. The primary outcome was organ donation after brain death. Independent risk factors were identified using logistic regression analysis. One-year graft survival was assessed using Cox and log-rank tests. Results Of the 3061 included patients, 136 (4.4%) became organ donors after brain death, i.e., 28% of the patients with brain death. An interaction between admission pH and post-resuscitation shock was identified. By multivariate analysis, in patients with post-resuscitation shock, factors associated with organ donation were neurological cause of OHCA (odds ratio [OR], 14.5 [7.6–27.4], P

Published
2022
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171. Nutritional biomarkers and heart failure requiring hospitalization in patients with type 2 diabetes: the SURDIAGENE cohort

Author

Matthieu Wargny, Mikaël Croyal, Stéphanie Ragot, Elise Gand, David Jacobi, Jean-Noël Trochu, Xavier Prieur, Cédric Le May, Thomas Goronflot, Bertrand Cariou, Pierre-Jean Saulnier, Samy Hadjadj, and for the SURDIAGENE study group

Subjects
TMAO, Nutritional biomarkers, Diabetes mellitus, Heart failure, Cohort study, Homocysteine, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Heart failure (HF) is a growing complication and one of the leading causes of mortality in people living with type 2 diabetes (T2D). Among the possible causes, the excess of red meat and the insufficiency of vegetables consumption are suspected. Such an alimentation is associated with nutritional biomarkers, including trimethylamine N-oxide (TMAO) and its precursors. Here, we aimed to study these biomarkers as potential prognostic factors for HF in patients with T2D. Methods We used the SURDIAGENE (SURvival DIAbetes and GENEtics) study, a large, prospective, monocentric cohort study including 1468 patients with T2D between 2001 and 2012. TMAO and its precursors (trimethylamine [TMA], betaine, choline, and carnitine) as well as thio-amino-acids (cysteine, homocysteine and methionine) were measured by liquid chromatography-tandem mass spectrometry. The main outcome was HF requiring Hospitalization (HFrH) defined as the first occurrence of acute HF leading to hospitalization and/or death, established by an adjudication committee, based on hospital records until 31st December 2015. The secondary outcomes were the composite event HFrH and/or cardiovascular death and all-cause death. The association between the biomarkers and the outcomes was studied using cause-specific hazard-models, adjusted for age, sex, history of coronary artery disease, NT-proBNP, CKD-EPI-derived eGFR and the urine albumin/creatinine ratio. Hazard-ratios (HR) are expressed for one standard deviation. Results The data of interest were available for 1349/1468 of SURDIAGENE participants (91.9%), including 569 (42.2%) women, with a mean age of 64.3 ± 10.7 years and a median follow-up of 7.3 years [25th–75th percentile, 4.7–10.8]. HFrH was reported in 209 patients (15.5%), HFrH and/or cardiovascular death in 341 (25.3%) and all-cause death in 447 (33.1%). In unadjusted hazard-models, carnitine (HR = 1.20, 95% CI [1.05; 1.37]), betaine (HR = 1.34, [1.20; 1.50]), choline (HR = 1.35, [1.20; 1.52]), TMAO (HR = 1.32, [1.16; 1.50]), cysteine (HR = 1.38, [1.21; 1.58]) and homocysteine (HR = 1.28, [1.17; 1.39]) were associated with HFrH, but not TMA and methionine. In the fully adjusted models, none of these associations was significant, neither for HFrH nor for HFrH and/or CV death, when homocysteine only was positively associated with all-cause death (HR = 1.16, [1.06; 1.27]). Conclusions TMAO and its precursors do not appear to be substantial prognosis factors for HFrH, beyond usual cardiac- and kidney-related risk factors, whereas homocysteine is an independent risk factor for all-cause death in patients with T2D.

Published
2022
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172. Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study

Author

Gayat, Etienne, Cariou, Alain, Deye, Nicolas, Vieillard-Baron, Antoine, Jaber, Samir, Damoisel, Charles, Lu, Qin, Monnet, Xavier, Rennuit, Isabelle, Azoulay, Elie, Léone, Marc, Oueslati, Heikel, Guidet, Bertrand, Friedman, Diane, Tesnière, Antoine, Sonneville, Romain, Montravers, Philippe, Pili-Floury, Sébastien, Lefrant, Jean-Yves, Duranteau, Jacques, Laterre, Pierre-François, Brechot, Nicolas, Chevreul, Karine, Michel, Morgane, Cholley, Bernard, Legrand, Matthieu, Launay, Jean-Marie, Vicaut, Eric, Singer, Mervyn, Resche-Rigon, Matthieu, and Mebazaa, Alexandre

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Clinical Research, Patient Safety, Cardiovascular, Heart Disease, Good Health and Well Being, Aged, Belgium, Cohort Studies, Critical Illness, Female, France, Hospital Mortality, Hospitalization, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Odds Ratio, Outcome Assessment, Health Care, Prospective Studies, Respiration, Artificial, Survivors, Time Factors, Vasoconstrictor Agents, Biomarkers, Discharge, Long-term survival, Post-intensive care syndrome, Score, Medical and Health Sciences, Emergency & Critical Care Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundIntensive care unit (ICU) survivors have reduced long-term survival compared to the general population. Identifying parameters at ICU discharge that are associated with poor long-term outcomes may prove useful in targeting an at-risk population. The main objective of the study was to identify clinical and biological determinants of death in the year following ICU discharge.MethodsFROG-ICU was a prospective, observational, multicenter cohort study of ICU survivors followed 1 year after discharge, including 21 medical, surgical or mixed ICUs in France and Belgium. All consecutive patients admitted to intensive care with a requirement for invasive mechanical ventilation and/or vasoactive drug support for more than 24 h following ICU admission and discharged from ICU were included. The main outcome measure was all-cause mortality at 1 year after ICU discharge. Clinical and biological parameters on ICU discharge were measured, including the circulating cardiovascular biomarkers N-terminal pro-B type natriuretic peptide, high-sensitive troponin I, bioactive-adrenomedullin and soluble-ST2. Socioeconomic status was assessed using a validated deprivation index (FDep).ResultsOf 1570 patients discharged alive from the ICU, 333 (21%) died over the following year. Multivariable analysis identified age, comorbidity, red blood cell transfusion, ICU length of stay and abnormalities in common clinical factors at the time of ICU discharge (low systolic blood pressure, temperature, total protein, platelet and white cell count) as independent factors associated with 1-year mortality. Elevated biomarkers of cardiac and vascular failure independently associated with 1-year death when they are added to multivariable model, with an almost 3-fold increase in the risk of death when combined (adjusted odds ratio 2.84 (95% confidence interval 1.73-4.65), p

Published
2018

174. Cardiomuscular Biomarkers in the Diagnosis and Prognostication of Immune Checkpoint Inhibitor Myocarditis

Author

Lehmann, Lorenz H., Heckmann, Markus B., Bailly, Guillaume, Finke, Daniel, Procureur, Adrien, Power, John R., Stein, Frederic, Bretagne, Marie, Ederhy, Stephane, Fenioux, Charlotte, Hamwy, Omar, Funck-Brentano, Elisa, Romano, Emanuela, Pieroni, Laurence, Münster, Jan P., Allenbach, Yves, Anquetil, Céline, Leonard-Louis, Sarah, Palaskas, Nicolas L., Hayek, Salim S., Katus, Hugo A., Giannitsis, Evangelos, Frey, Norbert, Kaya, Ziya, Moslehi, Javid, Prifti, Edi, Salem, Joe-Elie, Thuny, Franck, Crusz, Shanthini, Asnani, Aarti, Karlstaedt, Anja, Rocher, Fanny, Paven, Elise, Obeid, Michel, Chan, Wei Ting, Flint, Danette L, Arangalage, Dimitri, Courand, Pierre-Yves, Nicol, Martin, Cariou, Eve, Tamura, Yuichi, Florido, Roberta, Francis, Sanjeev, Leong, Darryl, Piriou, Nicolas, Akhter, Nausheen, Shahneen, Sandhu, Itzhaki Ben Zadok, Osnat, Habib, Manhal, Vachhani, Pankit, Peretto, Giovanni, Zhu, Han, Laufer Perl, Michal, Aras, Mandar, Alexandre, Joachim, Lenneman, Carrie, Levenson, Joshua, Deswal, Anita, Zaha, Vlad G., Gaughan, Elizabeth M, Ewer, Steven, Johnson, Douglas, and Baldassarre, Lauren A

Published
2023
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175. Correction: Impact of a Postintensive Care Unit Multidisciplinary Follow-up on the Quality of Life (SUIVI-REA): Protocol for a Multicenter Randomized Controlled Trial

Author

Diane Friedman, Lamiae Grimaldi, Alain Cariou, Philippe Aegerter, Stéphane Gaudry, Abdel Ben Salah, Haikel Oueslati, Bruno Megarbane, Nicolas Meunier-Beillard, Jean-Pierre Quenot, Carole Schwebel, Laurent Jacob, Ségloène Robin Lagandré, Pierre Kalfon, Romain Sonneville, Shidasp Siami, Aurelien Mazeraud, and Tarek Sharshar

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Published
2023
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176. Data quality control considerations in multivariate environmental monitoring: experience of the French coastal network SOMLIT

Author

Elsa Breton, Nicolas Savoye, Peggy Rimmelin-Maury, Benoit Sautour, Eric Goberville, Arnaud Lheureux, Thierry Cariou, Sophie Ferreira, Hélène Agogué, Samir Alliouane, Fabien Aubert, Sébastien Aubin, Eric Berthebaud, Hadrien Blayac, Lucie Blondel, Cédric Boulart, Yann Bozec, Sarah Bureau, Arnaud Caillo, Arnaud Cauvin, Jean-Baptiste Cazes, Léo Chasselin, Pascal Claquin, Pascal Conan, Marie-Ange Cordier, Laurence Costes, Romain Crec’hriou, Olivier Crispi, Muriel Crouvoisier, Valérie David, Yolanda Del Amo, Hortense De Lary, Gaspard Delebecq, Jeremy Devesa, Aurélien Domeau, Maria Durozier, Claire Emery, Eric Feunteun, Juliette Fauchot, Valérie Gentilhomme, Sandrine Geslin, Mélanie Giraud, Karine Grangeré, Gerald Grégori, Emilie Grossteffan, Aurore Gueux, Julien Guillaudeau, Gael Guillou, Manon Harrewyn, Orianne Jolly, Florence Jude-Lemeilleur, Paul Labatut, Nathalie Labourdette, Nicolas Lachaussée, Michel Lafont, Veronique Lagadec, Christophe Lambert, Jezebel Lamoureux, Laurent Lanceleur, Benoit Lebreton, Eric Lecuyer, David Lemeille, Yann Leredde, Cédric Leroux, Aude Leynaert, Stéphane L’Helguen, Camilla Liénart, Eric Macé, Eric Maria, Barbara Marie, Dominique Marie, Sébastien Mas, Fabrice Mendes, Line Mornet, Behzad Mostajir, Laure Mousseau, Antoine Nowaczyk, Sandra Nunige, René Parra, Thomas Paulin, David Pecqueur, Franck Petit, Philippe Pineau, Patrick Raimbault, Fabienne Rigaut-Jalabert, Christophe Salmeron, Ian Salter, Pierre-Guy Sauriau, Laurent Seuront, Emmanuelle Sultan, Rémi Valdès, Vincent Vantrepotte, Francesca Vidussi, Florian Voron, Renaud Vuillemin, Laurent. Zudaire, and Nicole Garcia

Subjects
environmental monitoring network, data quality control, inter-laboratory comparison exercises, measurement uncertainty, analyst performance, multivariate dataset, Science, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract

IntroductionWhile crucial to ensuring the production of accurate and high-quality data—and to avoid erroneous conclusions—data quality control (QC) in environmental monitoring datasets is still poorly documented.MethodsWith a focus on annual inter-laboratory comparison (ILC) exercises performed in the context of the French coastal monitoring SOMLIT network, we share here a pragmatic approach to QC, which allows the calculation of systematic and random errors, measurement uncertainty, and individual performance. After an overview of the different QC actions applied to fulfill requirements for quality and competence, we report equipment, accommodation, design of the ILC exercises, and statistical methodology specially adapted to small environmental networks (

Published
2023
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177. Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state

Author

Alexia Blandin, Isabelle Dugail, Grégory Hilairet, Maharajah Ponnaiah, Valentine Ghesquière, Josy Froger, Simon Ducheix, Lionel Fizanne, Jérôme Boursier, Bertrand Cariou, Marie Lhomme, and Soazig Le Lay

Subjects
CP: Metabolism, Biology (General), QH301-705.5
Abstract

Summary: Adipose extracellular vesicles (AdEVs) transport lipids that could participate in the development of obesity-related metabolic dysfunctions. This study aims to define mouse AdEV lipid signature by a targeted LC-MS/MS approach in either healthy or obesity context. Distinct clustering of AdEV and visceral adipose tissue (VAT) lipidomes by principal component analysis reveals specific AdEV lipid sorting when compared with secreting VAT. Comprehensive analysis identifies enrichment of ceramides, sphingomyelins, and phosphatidylglycerols species in AdEVs compared with source VAT whose lipid content closely relates to the obesity status and is influenced by the diet. Obesity moreover impacts AdEV lipidome, mirroring lipid alterations retrieved in plasma and VAT. Overall, our study identifies specific lipid fingerprints for plasma, VAT, and AdEVs that are informative of the metabolic status. Lipid species enriched in AdEVs in the obesity context may constitute biomarker candidates or mediators of the obesity-associated metabolic dysfunctions.

Published
2023
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179. Proportion and stage distribution of screen-detected and non-screen-detected colorectal cancer in nine European countries: an international, population-based study

Author

Cardoso, Rafael, Guo, Feng, Heisser, Thomas, De Schutter, Harlinde, Van Damme, Nancy, Nilbert, Mef Christina, Tybjerg, Anne Julie, Bouvier, Anne-Marie, Bouvier, Véronique, Launoy, Guy, Woronoff, Anne-Sophie, Cariou, Mélanie, Robaszkiewicz, Michel, Delafosse, Patricia, Poncet, Florence, Walsh, Paul M, Senore, Carlo, Rosso, Stefano, Lemmens, Valery E P P, Elferink, Marloes A G, Tomšič, Sonja, Žagar, Tina, Lopez de Munain Marques, Arantza, Marcos-Gragera, Rafael, Puigdemont, Montse, Galceran, Jaume, Carulla, Marià, Sánchez-Gil, Antonia, Chirlaque, María-Dolores, Hoffmeister, Michael, and Brenner, Hermann

Published
2022
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180. Targeted Temperature Management After In-Hospital Cardiac Arrest: An Ancillary Analysis of Targeted Temperature Management for Cardiac Arrest With Nonshockable Rhythm Trial Data

Author

Blanc, Alexiane, Colin, Gwenhael, Cariou, Alain, Merdji, Hamid, Grillet, Guillaume, Girardie, Patrick, Coupez, Elisabeth, Dequin, Pierre-François, Boulain, Thierry, Frat, Jean-Pierre, Asfar, Pierre, Pichon, Nicolas, Landais, Mickael, Plantefeve, Gaëtan, Quenot, Jean-Pierre, Chakarian, Jean-Charles, Sirodot, Michel, Legriel, Stéphane, Massart, Nicolas, Thevenin, Didier, Desachy, Arnaud, Delahaye, Arnaud, Botoc, Vlad, Vimeux, Sylvie, Martino, Frederic, Reignier, Jean, Taccone, F.S., and Lascarrou, J.B.

Published
2022
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190. Outcomes of mild-to-moderate postresuscitation shock after non-shockable cardiac arrest and association with temperature management: a post hoc analysis of HYPERION trial data

Author

Ziriat, Ines, Le Thuaut, Aurélie, Colin, Gwenhael, Merdji, Hamid, Grillet, Guillaume, Girardie, Patrick, Souweine, Bertrand, Dequin, Pierre-François, Boulain, Thierry, Frat, Jean-Pierre, Asfar, Pierre, Francois, Bruno, Landais, Mickael, Plantefeve, Gaëtan, Quenot, Jean-Pierre, Chakarian, Jean-Charles, Sirodot, Michel, Legriel, Stéphane, Massart, Nicolas, Thevenin, Didier, Desachy, Arnaud, Delahaye, Arnaud, Botoc, Vlad, Vimeux, Sylvie, Martino, Frederic, Reignier, Jean, Cariou, Alain, and Lascarrou, Jean Baptiste

Published
2022
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191. Influence of temperature management at 33 °C versus normothermia on survival in patients with vasopressor support after out-of-hospital cardiac arrest: a post hoc analysis of the TTM-2 trial

Author

Düring, Joachim, Annborn, Martin, Cariou, Alain, Chew, Michelle S., Dankiewicz, Josef, Friberg, Hans, Haenggi, Matthias, Haxhija, Zana, Jakobsen, Janus C., Langeland, Halvor, Taccone, Fabio Silvio, Thomas, Matthew, Ullén, Susann, Wise, Matt P., and Nielsen, Niklas

Published
2022
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193. Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Author

Simpson, Rupert F. G., Dankiewicz, Josef, Karamasis, Grigoris V., Pelosi, Paolo, Haenggi, Matthias, Young, Paul J., Jakobsen, Janus Christian, Bannard-Smith, Jonathan, Wendel-Garcia, Pedro D., Taccone, Fabio Silvio, Nordberg, Per, Wise, Matt P., Grejs, Anders M., Lilja, Gisela, Olsen, Roy Bjørkholt, Cariou, Alain, Lascarrou, Jean Baptiste, Saxena, Manoj, Hovdenes, Jan, Thomas, Matthew, Friberg, Hans, Davies, John R., Nielsen, Niklas, and Keeble, Thomas R.

Published
2022
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199. Resuming Training in High-Level Athletes After Mild COVID-19 Infection: A Multicenter Prospective Study (ASCCOVID-19)

Author

Chevalier, Laurent, Cochet, Hubert, Mahida, Saagar, S, Sylvain Blanchard, Benard, Antoine, Cariou, Tanguy, Sridi-Cheniti, Soumaya, Benhenda, Samy, Doutreleau, Stéphane, Cade, Stéphane, Guerard, Sylvain, Guy, Jean-Michel, Trimoulet, Pascale, Picard, Stéphane, Dusfour, Bernard, Pouzet, Aurelie, Roseng, Stéphanie, Franchi, Marco, Jaïs, Pierre, and Pellegrin, Isabelle

Published
2022
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