1,373 results on '"Campbell, Peter T"'
Search Results
152. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
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Turcot, Valérie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Gonçalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Galbany, Jordi Corominas, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D’Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian’an, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Nyholt, Dale R., O’Connel, Jeffrey R., O’Donoghue, Michelle L., Loohuis, Loes M. Olde, Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renström, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H.-H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Edwards, Digna R. Velez, Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Understanding Society Scientific Group, Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., and Loos, Ruth J. F.
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- 2019
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153. Long‐term weight loss after colorectal cancer diagnosis is associated with lower survival: The Colon Cancer Family Registry
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Kocarnik, Jonathan M., Hua, Xinwei, Hardikar, Sheetal, Robinson, Jamaica, Lindor, Noralane M., Win, Aung Ko, Hopper, John L., Figueiredo, Jane C., Potter, John D., Campbell, Peter T., Gallinger, Steven, Cotterchio, Michelle, Adams, Scott V., Cohen, Stacey A., Phipps, Amanda I., and Newcomb, Polly A.
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- 2017
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154. Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses.
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Dimou, Niki, Kim, Andre E., Flanagan, Orlagh, Murphy, Neil, Diez-Obrero, Virginia, Shcherbina, Anna, Aglago, Elom K., Bouras, Emmanouil, Campbell, Peter T., Casey, Graham, Gallinger, Steven, Gruber, Stephen B., Jenkins, Mark A., Lin, Yi, Moreno, Victor, Ruiz-Narvaez, Edward, Stern, Mariana C., Tian, Yu, Tsilidis, Kostas K., and Arndt, Volker
- Abstract
Background: Diabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis. Methods: We used data from 3 genetic consortia (CCFR, CORECT, GECCO; 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom; d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. joint test) and G-diabetes correlation (3-d.f. joint test). Results: Based on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes 8q24.11 (rs3802177, SLC30A8 – OR
AA : 1.62, 95% CI: 1.34–1.96; ORAG : 1.41, 95% CI: 1.30–1.54; ORGG : 1.22, 95% CI: 1.13–1.31; p-value3-d.f. : 5.46 × 10−11 ) and 13q14.13 (rs9526201, LRCH1 – ORGG : 2.11, 95% CI: 1.56–2.83; ORGA : 1.52, 95% CI: 1.38–1.68; ORAA : 1.13, 95% CI: 1.06–1.21; p-value2-d.f. : 7.84 × 10−09 ). Discussion: These results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship. [ABSTRACT FROM AUTHOR]- Published
- 2023
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155. Prospective Associations of Hemoglobin A1c and c-peptide with Risk of Diabetes-related Cancers in the Cancer Prevention Study-II Nutrition Cohort
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Campbell, Peter T., primary, Newton, Christina C., additional, Jacobs, Eric J., additional, McCullough, Marjorie L., additional, Wang, Ying, additional, Rees-Punia, Erika, additional, Guinter, Mark A., additional, Murphy, Neil, additional, Koshiol, Jill, additional, Dehal, Ahmed N., additional, Rohan, Thomas, additional, Strickler, Howard, additional, Petrick, Jessica, additional, Gunter, Marc, additional, Zhang, Xuehong, additional, McGlynn, Katherine A., additional, Pollak, Michael, additional, Patel, Alpa V., additional, and Gapstur, Susan M., additional
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- 2022
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156. Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study
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Papadimitriou, Nikos, primary, Bull, Caroline J, additional, Jenab, Mazda, additional, Hughes, David J, additional, Bell, Joshua, additional, Sanderson, Eleanor, additional, Timpson, Nicholas J, additional, Davey Smith, George, additional, Albanes, Demetrius, additional, Campbell, Peter T, additional, Kury, Sebastien, additional, Le Marchand, Loic, additional, Ulrich, Cornelia M, additional, Visvanathan, Kala, additional, Figueiredo, Jane C, additional, Newcomb, Polly A, additional, Pai, Rish K, additional, Peters, Ulrike, additional, Tsilidis, Konstantinos K, additional, Boer, Jolanda MA, additional, Vincent, Emma E, additional, Mariosa, Daniela, additional, Gunter, Marc J, additional, Richardson, Tom G, additional, and Murphy, Neil, additional
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- 2022
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157. Body Mass Index Trajectories, Weight Gain, and Risks of Liver and Biliary Tract Cancers
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Yang, Wanshui, primary, Zeng, Xufen, additional, Petrick, Jessica L, additional, Danford, Christopher J, additional, Florio, Andrea A, additional, Lu, Bing, additional, Nan, Hongmei, additional, Ma, Jiantao, additional, Wang, Liang, additional, Zeng, Hongmei, additional, Sudenga, Staci L, additional, Campbell, Peter T, additional, Giovannucci, Edward, additional, McGlynn, Katherine A, additional, and Zhang, Xuehong, additional
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- 2022
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158. Proceedings of the fifth international Molecular Pathological Epidemiology (MPE) meeting
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Yao, Song, primary, Campbell, Peter T., additional, Ugai, Tomotaka, additional, Gierach, Gretchen, additional, Abubakar, Mustapha, additional, Adalsteinsson, Viktor, additional, Almeida, Jonas, additional, Brennan, Paul, additional, Chanock, Stephen, additional, Golub, Todd, additional, Hanash, Samir, additional, Harris, Curtis, additional, Hathaway, Cassandra A., additional, Kelsey, Karl, additional, Landi, Maria Teresa, additional, Mahmood, Faisal, additional, Newton, Christina, additional, Quackenbush, John, additional, Rodig, Scott, additional, Schultz, Nikolaus, additional, Tearney, Guillermo, additional, Tworoger, Shelley S., additional, Wang, Molin, additional, Zhang, Xuehong, additional, Garcia-Closas, Montserrat, additional, Rebbeck, Timothy R., additional, Ambrosone, Christine B., additional, and Ogino, Shuji, additional
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- 2022
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159. Association between germline variants and somatic mutations in colorectal cancer
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Barfield, Richard, primary, Qu, Conghui, additional, Steinfelder, Robert S., additional, Zeng, Chenjie, additional, Harrison, Tabitha A., additional, Brezina, Stefanie, additional, Buchanan, Daniel D., additional, Campbell, Peter T., additional, Casey, Graham, additional, Gallinger, Steven, additional, Giannakis, Marios, additional, Gruber, Stephen B., additional, Gsur, Andrea, additional, Hsu, Li, additional, Huyghe, Jeroen R., additional, Moreno, Victor, additional, Newcomb, Polly A., additional, Ogino, Shuji, additional, Phipps, Amanda I., additional, Slattery, Martha L., additional, Thibodeau, Stephen N., additional, Trinh, Quang M., additional, Toland, Amanda E., additional, Hudson, Thomas J., additional, Sun, Wei, additional, Zaidi, Syed H., additional, and Peters, Ulrike, additional
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- 2022
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160. Abstract 730: Fruit and vegetable consumption and risk of liver cancer and liver disease mortality: A prospective cohort study
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Zhao, Longgang, primary, Jin, Lina, additional, Petrick, Jessica L., additional, Wang, Fenglei, additional, Li, Tang, additional, Zeng, Hongmei, additional, Smith-Warner, Stephanie A., additional, Eliassen, A. Heather, additional, Zhang, Fang Fang, additional, Campbell, Peter T., additional, Giovannucci, Edward, additional, Liao, Linda M., additional, Steck, Susan E., additional, McGlynn, Katherine A., additional, and Zhang, Xuehong, additional
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- 2022
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161. The Associations of Multivitamin and Antioxidant Use With Mortality Among Women and Men Diagnosed With Colorectal Cancer
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Figueiredo, Jane C, primary, Guinter, Mark A, additional, Newton, Christina C, additional, McCullough, Marjorie L, additional, Um, Caroline Y, additional, Patel, Alpa V, additional, and Campbell, Peter T, additional
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- 2022
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162. Identifying colorectal cancer caused by biallelic MUTYH pathogenic variants using tumor mutational signatures
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Georgeson, Peter, primary, Harrison, Tabitha A., additional, Pope, Bernard J., additional, Zaidi, Syed H., additional, Qu, Conghui, additional, Steinfelder, Robert S., additional, Lin, Yi, additional, Joo, Jihoon E., additional, Mahmood, Khalid, additional, Clendenning, Mark, additional, Walker, Romy, additional, Amitay, Efrat L., additional, Berndt, Sonja I., additional, Brenner, Hermann, additional, Campbell, Peter T., additional, Cao, Yin, additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Doheny, Kimberly F., additional, Drew, David A., additional, Figueiredo, Jane C., additional, French, Amy J., additional, Gallinger, Steven, additional, Giannakis, Marios, additional, Giles, Graham G., additional, Gsur, Andrea, additional, Gunter, Marc J., additional, Hoffmeister, Michael, additional, Hsu, Li, additional, Huang, Wen-Yi, additional, Limburg, Paul, additional, Manson, JoAnn E., additional, Moreno, Victor, additional, Nassir, Rami, additional, Nowak, Jonathan A., additional, Obón-Santacana, Mireia, additional, Ogino, Shuji, additional, Phipps, Amanda I., additional, Potter, John D., additional, Schoen, Robert E., additional, Sun, Wei, additional, Toland, Amanda E., additional, Trinh, Quang M., additional, Ugai, Tomotaka, additional, Macrae, Finlay A., additional, Rosty, Christophe, additional, Hudson, Thomas J., additional, Jenkins, Mark A., additional, Thibodeau, Stephen N., additional, Winship, Ingrid M., additional, Peters, Ulrike, additional, and Buchanan, Daniel D., additional
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- 2022
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163. Diabetes mellitus in relation to colorectal tumor molecular subtypes : a pooled analysis of more than 9000 cases
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Harlid, Sophia, van Guelpen, Bethany, Qu, Conghui, Gylling, Björn, Aglago, Elom K., Amitay, Efrat L., Brenner, Hermann, Buchanan, Daniel D., Campbell, Peter T., Cao, Yin, Chan, Andrew T., Chang-Claude, Jenny, Drew, David A., Figueiredo, Jane C., French, Amy J., Gallinger, Steven, Giannakis, Marios, Giles, Graham G., Gunter, Marc J., Hoffmeister, Michael, Hsu, Li, Jenkins, Mark A., Lin, Yi, Moreno, Victor, Murphy, Neil, Newcomb, Polly A., Newton, Christina C., Nowak, Jonathan A., Obón-Santacana, Mireia, Ogino, Shuji, Potter, John D., Song, Mingyang, Steinfelder, Robert S., Sun, Wei, Thibodeau, Stephen N., Toland, Amanda E., Ugai, Tomotaka, Um, Caroline Y., Woods, Michael O., Phipps, Amanda I., Harrison, Tabitha, Peters, Ulrike, Harlid, Sophia, van Guelpen, Bethany, Qu, Conghui, Gylling, Björn, Aglago, Elom K., Amitay, Efrat L., Brenner, Hermann, Buchanan, Daniel D., Campbell, Peter T., Cao, Yin, Chan, Andrew T., Chang-Claude, Jenny, Drew, David A., Figueiredo, Jane C., French, Amy J., Gallinger, Steven, Giannakis, Marios, Giles, Graham G., Gunter, Marc J., Hoffmeister, Michael, Hsu, Li, Jenkins, Mark A., Lin, Yi, Moreno, Victor, Murphy, Neil, Newcomb, Polly A., Newton, Christina C., Nowak, Jonathan A., Obón-Santacana, Mireia, Ogino, Shuji, Potter, John D., Song, Mingyang, Steinfelder, Robert S., Sun, Wei, Thibodeau, Stephen N., Toland, Amanda E., Ugai, Tomotaka, Um, Caroline Y., Woods, Michael O., Phipps, Amanda I., Harrison, Tabitha, and Peters, Ulrike
- Abstract
Diabetes is an established risk factor for colorectal cancer. However, colorectal cancer is a heterogeneous disease and it is not well understood whether diabetes is more strongly associated with some tumor molecular subtypes than others. A better understanding of the association between diabetes and colorectal cancer according to molecular subtypes could provide important insights into the biology of this association. We used data on lifestyle and clinical characteristics from the Colorectal Cancer Family Registry (CCFR) and the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), including 9756 colorectal cancer cases (with tumor marker data) and 9985 controls, to evaluate associations between reported diabetes and risk of colorectal cancer according to molecular subtypes. Tumor markers included BRAF and KRAS mutations, microsatellite instability and CpG island methylator phenotype. In the multinomial logistic regression model, comparing colorectal cancer cases to cancer-free controls, diabetes was positively associated with colorectal cancer regardless of subtype. The highest OR estimate was found for BRAF-mutated colorectal cancer, n = 1086 (ORfully adj: 1.67, 95% confidence intervals [CI]: 1.36-2.05), with an attenuated association observed between diabetes and colorectal cancer without BRAF-mutations, n = 7959 (ORfully adj: 1.33, 95% CI: 1.19-1.48). In the case only analysis, BRAF-mutation was differentially associated with diabetes (Pdifference = .03). For the other markers, associations with diabetes were similar across tumor subtypes. In conclusion, our study confirms the established association between diabetes and colorectal cancer risk, and suggests that it particularly increases the risk of BRAF-mutated tumors.
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- 2022
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164. Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival
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Labadie, Julia D., Savas, Sevtap, Harrison, Tabitha A., Banbury, Barb, Huang, Yuhan, Buchanan, Daniel D., Campbell, Peter T., Gallinger, Steven J., Giles, Graham G., Gunter, Marc J., Hoffmeister, Michael, Hsu, Li, Jenkins, Mark A., Lin, Yi, Ogino, Shuji, Phipps, Amanda I., Slattery, Martha L., Steinfelder, Robert S., Sun, Wei, van Guelpen, Bethany, Hua, Xinwei, Figuieredo, Jane C., Pai, Rish K., Nassir, Rami, Qi, Lihong, Chan, Andrew T., Peters, Ulrike, Newcomb, Polly A., Labadie, Julia D., Savas, Sevtap, Harrison, Tabitha A., Banbury, Barb, Huang, Yuhan, Buchanan, Daniel D., Campbell, Peter T., Gallinger, Steven J., Giles, Graham G., Gunter, Marc J., Hoffmeister, Michael, Hsu, Li, Jenkins, Mark A., Lin, Yi, Ogino, Shuji, Phipps, Amanda I., Slattery, Martha L., Steinfelder, Robert S., Sun, Wei, van Guelpen, Bethany, Hua, Xinwei, Figuieredo, Jane C., Pai, Rish K., Nassir, Rami, Qi, Lihong, Chan, Andrew T., Peters, Ulrike, and Newcomb, Polly A.
- Abstract
Identification of new genetic markers may improve the prediction of colorectal cancer prognosis. Our objective was to examine genome-wide associations of germline genetic variants with disease-specific survival in an analysis of 16,964 cases of colorectal cancer. We analyzed genotype and colorectal cancer-specific survival data from a consortium of 15 studies. Approximately 7.5 million SNPs were examined under the log-additive model using Cox proportional hazards models, adjusting for clinical factors and principal components. Additionally, we ran secondary analyses stratifying by tumor site and disease stage. We used a genome-wide p-value threshold of 5 × 10–8 to assess statistical significance. No variants were statistically significantly associated with disease-specific survival in the full case analysis or in the stage-stratified analyses. Three SNPs were statistically significantly associated with disease-specific survival for cases with tumors located in the distal colon (rs698022, HR = 1.48, CI 1.30–1.69, p = 8.47 × 10–9) and the proximal colon (rs189655236, HR = 2.14, 95% CI 1.65–2.77, p = 9.19 × 10–9 and rs144717887, HR = 2.01, 95% CI 1.57–2.58, p = 3.14 × 10–8), whereas no associations were detected for rectal tumors. Findings from this large genome-wide association study highlight the potential for anatomical-site-stratified genome-wide studies to identify germline genetic risk variants associated with colorectal cancer-specific survival. Larger sample sizes and further replication efforts are needed to more fully interpret these findings.
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- 2022
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165. Molecular and Pathology Features of Colorectal Tumors and Patient Outcomes Are Associated with Fusobacterium nucleatum and Its Subspecies animalis
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Borozan, Ivan, Zaidi, Syed H., Harrison, Tabitha A., Phipps, Amanda I., Zheng, Jiayin, Lee, Stephen, Trinh, Quang M., Steinfelder, Robert S., Adams, Jeremy, Banbury, Barbara L., Berndt, Sonja I., Brezina, Stefanie, Buchanan, Daniel D., Bullman, Susan, Cao, Yin, Farris III, Alton B., Figueiredo, Jane C., Giannakis, Marios, Heisler, Lawrence E., Hopper, John L., Lin, Yi, Luo, Xuemei, Nishihara, Reiko, Mardis, Elaine R., Papadopoulos, Nickolas, Qu, Conghui, Reid, Emma E.G., Thibodeau, Stephen N., Harlid, Sophia, Um, Caroline Y., Hsu, Li, Gsur, Andrea, Campbell, Peter T., Gallinger, Steven, Newcomb, Polly A., Ogino, Shuji, Sun, Wei, Hudson, Thomas J., Ferretti, Vincent, Peters, Ulrike, Borozan, Ivan, Zaidi, Syed H., Harrison, Tabitha A., Phipps, Amanda I., Zheng, Jiayin, Lee, Stephen, Trinh, Quang M., Steinfelder, Robert S., Adams, Jeremy, Banbury, Barbara L., Berndt, Sonja I., Brezina, Stefanie, Buchanan, Daniel D., Bullman, Susan, Cao, Yin, Farris III, Alton B., Figueiredo, Jane C., Giannakis, Marios, Heisler, Lawrence E., Hopper, John L., Lin, Yi, Luo, Xuemei, Nishihara, Reiko, Mardis, Elaine R., Papadopoulos, Nickolas, Qu, Conghui, Reid, Emma E.G., Thibodeau, Stephen N., Harlid, Sophia, Um, Caroline Y., Hsu, Li, Gsur, Andrea, Campbell, Peter T., Gallinger, Steven, Newcomb, Polly A., Ogino, Shuji, Sun, Wei, Hudson, Thomas J., Ferretti, Vincent, and Peters, Ulrike
- Abstract
Background: Fusobacterium nucleatum (F. nucleatum) activates oncogenic signaling pathways and induces inflammation to promote colorectal carcinogenesis. Methods: We characterized F. nucleatum and its subspecies in colorectal tumors and examined associations with tumor characteristics and colorectal cancer-specific survival. We conducted deep sequencing of nusA, nusG, and bacterial 16s rRNA genes in tumors from 1,994 patients with colorectal cancer and assessed associations between F. nucleatum presence and clinical characteristics, colorectal cancer-specific mortality, and somatic mutations. Results: F. nucleatum, which was present in 10.3% of tumors, was detected in a higher proportion of right-sided and advanced-stage tumors, particularly subspecies animalis. Presence of F. nucleatum was associated with higher colorectal cancer-specific mortality (HR, 1.97; P = 0.0004). This association was restricted to nonhypermutated, microsatellite-stable tumors (HR, 2.13; P = 0.0002) and those who received chemotherapy [HR, 1.92; confidence interval (CI), 1.07-3.45; P = 0.029). Only F. nucleatum subspecies animalis, the main subspecies detected (65.8%), was associated with colorectal cancer-specific mortality (HR, 2.16; P = 0.0016), subspecies vincentii and nucleatum were not (HR, 1.07; P = 0.86). Additional adjustment for tumor stage suggests that the effect of F. nucleatum on mortality is partly driven by a stage shift. Presence of F. nucleatum was associated with microsatellite instable tumors, tumors with POLE exonuclease domain mutations, and ERBB3 mutations, and suggestively associated with TP53 mutations. Conclusions: F. nucleatum, and particularly subspecies animalis, was associated with a higher colorectal cancer-specific mortality and specific somatic mutated genes.
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- 2022
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166. Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk
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Tian, Yu, Kim, Andre E, Bien, Stephanie A, Lin, Yi, Qu, Conghui, Harrison, Tabitha A, Carreras-Torres, Robert, Díez-Obrero, Virginia, Dimou, Niki, Drew, David A, Hidaka, Akihisa, Huyghe, Jeroen R, Jordahl, Kristina M, Morrison, John, Murphy, Neil, Obón-Santacana, Mireia, Ulrich, Cornelia M, Ose, Jennifer, Peoples, Anita R, Ruiz-Narvaez, Edward A, Shcherbina, Anna, Stern, Mariana C, Su, Yu-Ru, van Duijnhoven, Franzel J B, Arndt, Volker, Baurley, James W, Berndt, Sonja I, Bishop, D Timothy, Brenner, Hermann, Buchanan, Daniel D, Chan, Andrew T, Figueiredo, Jane C, Gallinger, Steven, Gruber, Stephen B, Harlid, Sophia, Hoffmeister, Michael, Jenkins, Mark A, Joshi, Amit D, Keku, Temitope O, Larsson, Susanna C., Le Marchand, Loic, Li, Li, Giles, Graham G, Milne, Roger L, Nan, Hongmei, Nassir, Rami, Ogino, Shuji, Budiarto, Arif, Platz, Elizabeth A, Potter, John D, Prentice, Ross L, Rennert, Gad, Sakoda, Lori C, Schoen, Robert E, Slattery, Martha L, Thibodeau, Stephen N, Van Guelpen, Bethany, Visvanathan, Kala, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Campbell, Peter T, Casey, Graham, Conti, David V, Gunter, Marc J, Kundaje, Anshul, Lewinger, Juan Pablo, Moreno, Victor, Newcomb, Polly A, Pardamean, Bens, Thomas, Duncan C, Tsilidis, Konstantinos K, Peters, Ulrike, Gauderman, W James, Hsu, Li, Chang-Claude, Jenny, Tian, Yu, Kim, Andre E, Bien, Stephanie A, Lin, Yi, Qu, Conghui, Harrison, Tabitha A, Carreras-Torres, Robert, Díez-Obrero, Virginia, Dimou, Niki, Drew, David A, Hidaka, Akihisa, Huyghe, Jeroen R, Jordahl, Kristina M, Morrison, John, Murphy, Neil, Obón-Santacana, Mireia, Ulrich, Cornelia M, Ose, Jennifer, Peoples, Anita R, Ruiz-Narvaez, Edward A, Shcherbina, Anna, Stern, Mariana C, Su, Yu-Ru, van Duijnhoven, Franzel J B, Arndt, Volker, Baurley, James W, Berndt, Sonja I, Bishop, D Timothy, Brenner, Hermann, Buchanan, Daniel D, Chan, Andrew T, Figueiredo, Jane C, Gallinger, Steven, Gruber, Stephen B, Harlid, Sophia, Hoffmeister, Michael, Jenkins, Mark A, Joshi, Amit D, Keku, Temitope O, Larsson, Susanna C., Le Marchand, Loic, Li, Li, Giles, Graham G, Milne, Roger L, Nan, Hongmei, Nassir, Rami, Ogino, Shuji, Budiarto, Arif, Platz, Elizabeth A, Potter, John D, Prentice, Ross L, Rennert, Gad, Sakoda, Lori C, Schoen, Robert E, Slattery, Martha L, Thibodeau, Stephen N, Van Guelpen, Bethany, Visvanathan, Kala, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Campbell, Peter T, Casey, Graham, Conti, David V, Gunter, Marc J, Kundaje, Anshul, Lewinger, Juan Pablo, Moreno, Victor, Newcomb, Polly A, Pardamean, Bens, Thomas, Duncan C, Tsilidis, Konstantinos K, Peters, Ulrike, Gauderman, W James, Hsu, Li, and Chang-Claude, Jenny
- Abstract
BACKGROUND: The use of menopausal hormone therapy (MHT) may interact with genetic variants to influence colorectal cancer (CRC) risk. METHODS: We conducted a genome-wide, gene-environment interaction between single nucleotide polymorphisms and the use of any MHT, estrogen only, and combined estrogen-progestogen therapy with CRC risk, among 28 486 postmenopausal women (11 519 CRC patients and 16 967 participants without CRC) from 38 studies, using logistic regression, 2-step method, and 2- or 3-degree-of-freedom joint test. A set-based score test was applied for rare genetic variants. RESULTS: The use of any MHT, estrogen only and estrogen-progestogen were associated with a reduced CRC risk (odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.64 to 0.78; OR = 0.65, 95% CI = 0.53 to 0.79; and OR = 0.73, 95% CI = 0.59 to 0.90, respectively). The 2-step method identified a statistically significant interaction between a GRIN2B variant rs117868593 and MHT use, whereby MHT-associated CRC risk was statistically significantly reduced in women with the GG genotype (OR = 0.68, 95% CI = 0.64 to 0.72) but not within strata of GC or CC genotypes. A statistically significant interaction between a DCBLD1 intronic variant at 6q22.1 (rs10782186) and MHT use was identified by the 2-degree-of-freedom joint test. The MHT-associated CRC risk was reduced with increasing number of rs10782186-C alleles, showing odds ratios of 0.78 (95% CI = 0.70 to 0.87) for TT, 0.68 (95% CI = 0.63 to 0.73) for TC, and 0.66 (95% CI = 0.60 to 0.74) for CC genotypes. In addition, 5 genes in rare variant analysis showed suggestive interactions with MHT (2-sided P < 1.2 × 10-4). CONCLUSION: Genetic variants that modify the association between MHT and CRC risk were identified, offering new insights into pathways of CRC carcinogenesis and potential mechanisms involved.
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- 2022
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167. Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival.
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Labadie, Julia D, Labadie, Julia D, Savas, Sevtap, Harrison, Tabitha A, Banbury, Barb, Huang, Yuhan, Buchanan, Daniel D, Campbell, Peter T, Gallinger, Steven J, Giles, Graham G, Gunter, Marc J, Hoffmeister, Michael, Hsu, Li, Jenkins, Mark A, Lin, Yi, Ogino, Shuji, Phipps, Amanda I, Slattery, Martha L, Steinfelder, Robert S, Sun, Wei, Van Guelpen, Bethany, Hua, Xinwei, Figuieredo, Jane C, Pai, Rish K, Nassir, Rami, Qi, Lihong, Chan, Andrew T, Peters, Ulrike, Newcomb, Polly A, Labadie, Julia D, Labadie, Julia D, Savas, Sevtap, Harrison, Tabitha A, Banbury, Barb, Huang, Yuhan, Buchanan, Daniel D, Campbell, Peter T, Gallinger, Steven J, Giles, Graham G, Gunter, Marc J, Hoffmeister, Michael, Hsu, Li, Jenkins, Mark A, Lin, Yi, Ogino, Shuji, Phipps, Amanda I, Slattery, Martha L, Steinfelder, Robert S, Sun, Wei, Van Guelpen, Bethany, Hua, Xinwei, Figuieredo, Jane C, Pai, Rish K, Nassir, Rami, Qi, Lihong, Chan, Andrew T, Peters, Ulrike, and Newcomb, Polly A
- Abstract
Identification of new genetic markers may improve the prediction of colorectal cancer prognosis. Our objective was to examine genome-wide associations of germline genetic variants with disease-specific survival in an analysis of 16,964 cases of colorectal cancer. We analyzed genotype and colorectal cancer-specific survival data from a consortium of 15 studies. Approximately 7.5 million SNPs were examined under the log-additive model using Cox proportional hazards models, adjusting for clinical factors and principal components. Additionally, we ran secondary analyses stratifying by tumor site and disease stage. We used a genome-wide p-value threshold of 5 × 10-8 to assess statistical significance. No variants were statistically significantly associated with disease-specific survival in the full case analysis or in the stage-stratified analyses. Three SNPs were statistically significantly associated with disease-specific survival for cases with tumors located in the distal colon (rs698022, HR = 1.48, CI 1.30-1.69, p = 8.47 × 10-9) and the proximal colon (rs189655236, HR = 2.14, 95% CI 1.65-2.77, p = 9.19 × 10-9 and rs144717887, HR = 2.01, 95% CI 1.57-2.58, p = 3.14 × 10-8), whereas no associations were detected for rectal tumors. Findings from this large genome-wide association study highlight the potential for anatomical-site-stratified genome-wide studies to identify germline genetic risk variants associated with colorectal cancer-specific survival. Larger sample sizes and further replication efforts are needed to more fully interpret these findings.
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- 2022
168. Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry
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Phipps, Amanda I., Robinson, Jamaica R., Campbell, Peter T., Win, Aung Ko, Figueiredo, Jane C., Lindor, Noralane M., and Newcomb, Polly A.
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- 2017
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169. Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases.
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Tomotaka Ugai, Koichiro Haruki, Harrison, Tabitha A., Yin Cao, Conghui Qu, Chan, Andrew T., Campbell, Peter T., Naohiko Akimoto, Berndt, Sonja, Brenner, Hermann, Buchanan, Daniel D., Chang-Claude, Jenny, Kenji Fujiyoshi, Gallinger, Steven J., Gunter, Marc J., Akihisa Hidaka, Hoffmeister, Michael, Li Hsu, Jenkins, Mark A., and Milne, Roger L.
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- 2023
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170. Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases.
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Ugai, Tomotaka, Akimoto, Naohiko, Haruki, Koichiro, Harrison, Tabitha A., Cao, Yin, Qu, Conghui, Chan, Andrew T., Campbell, Peter T., Berndt, Sonja I., Buchanan, Daniel D., Cross, Amanda J., Diergaarde, Brenda, Gallinger, Steven J., Gunter, Marc J., Harlid, Sophia, Hidaka, Akihisa, Hoffmeister, Michael, Brenner, Hermann, Chang-Claude, Jenny, and Hsu, Li
- Subjects
COLORECTAL cancer ,COLON tumors ,SIGMOID colon ,CANCER patients ,COLON cancer - Abstract
Background: The pathogenic effect of colorectal tumor molecular features may be influenced by several factors, including those related to microbiota, inflammation, metabolism, and epigenetics, which may change along colorectal segments. We hypothesized that the prognostic association of colon cancer location might differ by tumor molecular characteristics. Methods: Utilizing a consortium dataset of 13,101 colorectal cancer cases, including 2994 early-onset cases, we conducted survival analyses of detailed tumor location stratified by statuses of microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and KRAS and BRAF oncogenic mutation. Results: There was a statistically significant trend for better colon cancer-specific survival in relation to tumor location from the cecum to sigmoid colon (P
trend = 0.002), excluding the rectum. The prognostic association of colon location differed by MSI status (Pinteraction = 0.001). Non-MSI-high tumors exhibited the cecum-to-sigmoid trend for better colon cancer-specific survival [Ptrend < 0.001; multivariable hazard ratio (HR) for the sigmoid colon (vs. cecum), 0.80; 95% confidence interval (CI) 0.70–0.92], whereas MSI-high tumors demonstrated a suggestive cecum-to-sigmoid trend for worse survival (Ptrend = 0.020; the corresponding HR, 2.13; 95% CI 1.15–3.92). The prognostic association of colon tumor location also differed by CIMP status (Pinteraction = 0.003) but not significantly by age, stage, or other features. Furthermore, MSI-high status was a favorable prognostic indicator in all stages. Conclusions: Both detailed colonic location and tumor molecular features need to be accounted for colon cancer prognostication to advance precision medicine. Our study indicates the important role of large-scale studies to robustly examine detailed colonic subsites in molecular oncology research. [ABSTRACT FROM AUTHOR]- Published
- 2023
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171. A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1
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Lemire, Mathieu, Qu, Conghui, Loo, Lenora W. M., Zaidi, Syed H. E., Wang, Hansong, Berndt, Sonja I., Bézieau, Stéphane, Brenner, Hermann, Campbell, Peter T., Chan, Andrew T., Chang-Claude, Jenny, Du, Mengmeng, Edlund, Christopher K., Gallinger, Steven, Haile, Robert W., Harrison, Tabitha A., Hoffmeister, Michael, Hopper, John L., Hou, Lifang, Hsu, Li, Jacobs, Eric J., Jenkins, Mark A., Jeon, Jihyoun, Küry, Sébastien, Li, Li, Lindor, Noralane M., Newcomb, Polly A., Potter, John D., Rennert, Gad, Rudolph, Anja, Schoen, Robert E., Schumacher, Fredrick R., Seminara, Daniela, Severi, Gianluca, Slattery, Martha L., White, Emily, Woods, Michael O., Cotterchio, Michelle, Le Marchand, Loïc, Casey, Graham, Gruber, Stephen B., Peters, Ulrike, and Hudson, Thomas J.
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- 2015
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172. Garlic consumption and colorectal cancer risk in the CPS-II Nutrition Cohort
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McCullough, Marjorie L., Jacobs, Eric J., Shah, Roma, Campbell, Peter T., and Gapstur, Susan M.
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- 2012
173. Association Between Colorectal Cancer Susceptibility Loci and Survival Time After Diagnosis With Colorectal Cancer
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Phipps, Amanda I., Newcomb, Polly A., Garcia–Albeniz, Xabier, Hutter, Carolyn M., White, Emily, Fuchs, Charles S., Hazra, Aditi, Ogino, Shuji, Nan, Hongmei, Ma, Jing, Campbell, Peter T., Figueiredo, Jane C., Peters, Ulrike, and Chan, Andrew T.
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- 2012
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174. Patient acceptance of long head of biceps brachii tenotomy
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Duff, Samuel J. and Campbell, Peter T.
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- 2012
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175. Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk
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Tian, Yu, primary, Kim, Andre E, additional, Bien, Stephanie A, additional, Lin, Yi, additional, Qu, Conghui, additional, Harrison, Tabitha A, additional, Carreras-Torres, Robert, additional, Díez-Obrero, Virginia, additional, Dimou, Niki, additional, Drew, David A, additional, Hidaka, Akihisa, additional, Huyghe, Jeroen R, additional, Jordahl, Kristina M, additional, Morrison, John, additional, Murphy, Neil, additional, Obón-Santacana, Mireia, additional, Ulrich, Cornelia M, additional, Ose, Jennifer, additional, Peoples, Anita R, additional, Ruiz-Narvaez, Edward A, additional, Shcherbina, Anna, additional, Stern, Mariana C, additional, Su, Yu-Ru, additional, van Duijnhoven, Franzel J B, additional, Arndt, Volker, additional, Baurley, James W, additional, Berndt, Sonja I, additional, Bishop, D Timothy, additional, Brenner, Hermann, additional, Buchanan, Daniel D, additional, Chan, Andrew T, additional, Figueiredo, Jane C, additional, Gallinger, Steven, additional, Gruber, Stephen B, additional, Harlid, Sophia, additional, Hoffmeister, Michael, additional, Jenkins, Mark A, additional, Joshi, Amit D, additional, Keku, Temitope O, additional, Larsson, Susanna C, additional, Le Marchand, Loic, additional, Li, Li, additional, Giles, Graham G, additional, Milne, Roger L, additional, Nan, Hongmei, additional, Nassir, Rami, additional, Ogino, Shuji, additional, Budiarto, Arif, additional, Platz, Elizabeth A, additional, Potter, John D, additional, Prentice, Ross L, additional, Rennert, Gad, additional, Sakoda, Lori C, additional, Schoen, Robert E, additional, Slattery, Martha L, additional, Thibodeau, Stephen N, additional, Van Guelpen, Bethany, additional, Visvanathan, Kala, additional, White, Emily, additional, Wolk, Alicja, additional, Woods, Michael O, additional, Wu, Anna H, additional, Campbell, Peter T, additional, Casey, Graham, additional, Conti, David V, additional, Gunter, Marc J, additional, Kundaje, Anshul, additional, Lewinger, Juan Pablo, additional, Moreno, Victor, additional, Newcomb, Polly A, additional, Pardamean, Bens, additional, Thomas, Duncan C, additional, Tsilidis, Konstantinos K, additional, Peters, Ulrike, additional, Gauderman, W James, additional, Hsu, Li, additional, and Chang-Claude, Jenny, additional
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- 2022
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176. Diabetes mellitus in relation to colorectal tumor molecular subtypes: A pooled analysis of more than 9000 cases
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Harlid, Sophia, primary, Van Guelpen, Bethany, additional, Qu, Conghui, additional, Gylling, Björn, additional, Aglago, Elom K., additional, Amitay, Efrat L., additional, Brenner, Hermann, additional, Buchanan, Daniel D., additional, Campbell, Peter T., additional, Cao, Yin, additional, Chan, Andrew T., additional, Chang‐Claude, Jenny, additional, Drew, David A., additional, Figueiredo, Jane C., additional, French, Amy J., additional, Gallinger, Steven, additional, Giannakis, Marios, additional, Giles, Graham G., additional, Gunter, Marc J., additional, Hoffmeister, Michael, additional, Hsu, Li, additional, Jenkins, Mark A., additional, Lin, Yi, additional, Moreno, Victor, additional, Murphy, Neil, additional, Newcomb, Polly A., additional, Newton, Christina C., additional, Nowak, Jonathan A., additional, Obón‐Santacana, Mireia, additional, Ogino, Shuji, additional, Potter, John D., additional, Song, Mingyang, additional, Steinfelder, Robert S., additional, Sun, Wei, additional, Thibodeau, Stephen N., additional, Toland, Amanda E., additional, Ugai, Tomotaka, additional, Um, Caroline Y., additional, Woods, Michael O., additional, Phipps, Amanda I., additional, Harrison, Tabitha, additional, and Peters, Ulrike, additional
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- 2022
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177. Genetic Regulation of DNA Methylation Yields Novel Discoveries in GWAS of Colorectal Cancer
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Barfield, Richard, primary, Huyghe, Jeroen R., additional, Lemire, Mathieu, additional, Dong, Xinyuan, additional, Su, Yu-Ru, additional, Brezina, Stefanie, additional, Buchanan, Daniel D., additional, Figueiredo, Jane C., additional, Gallinger, Steven, additional, Giannakis, Marios, additional, Gsur, Andrea, additional, Gunter, Marc J., additional, Hampel, Heather, additional, Harrison, Tabitha A., additional, Hopper, John L., additional, Hudson, Thomas J., additional, Li, Christopher I., additional, Moreno, Victor, additional, Newcomb, Polly A., additional, Pai, Rish K., additional, Pharoah, Paul D.P., additional, Phipps, Amanda I., additional, Qu, Conghui, additional, Steinfelder, Robert S., additional, Sun, Wei, additional, Win, Aung Ko, additional, Zaidi, Syed H., additional, Campbell, Peter T., additional, Peters, Ulrike, additional, and Hsu, Li, additional
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- 2022
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178. Calcium and Vitamin D and Risk of Colorectal Cancer: Results From a Large Population-based Case-control Study in Newfoundland and Labrador and Ontario
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Sun, Zhuoyu, Wang, Peizhong Peter, Roebothan, Barbara, Cotterchio, Michelle, Green, Roger, Buehler, Sharon, Zhao, Jinhui, Squires, Josh, Zhao, Jing, Zhu, Yun, Dicks, Elizabeth, Campbell, Peter T., Mclaughlin, John R., and Parfrey, Patrick S.
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- 2011
179. Genes involved with folate uptake and distribution and their association with colorectal cancer risk
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Figueiredo, Jane C., Levine, A. Joan, Lee, Won H., Conti, David V., Poynter, Jenny N., Campbell, Peter T., Duggan, David, Lewinger, Juan Pablo, Martinez, Maria Elena, Ulrich, Cornelia M., Newcomb, Polly, Potter, John, Limburg, Paul J., Hopper, John, Jenkins, Mark A., Le Marchand, Loic, Baron, John A., and Haile, Robert W.
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- 2010
180. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
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Turcot, Valérie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Gonçalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Corominas Galbany, Jordi, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D’Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian’an, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Nyholt, Dale R., O’Connel, Jeffrey R., O’Donoghue, Michelle L., Olde Loohuis, Loes M., Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renström, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H.-H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Velez Edwards, Digna R., Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., Loos, Ruth J. F., CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, and Understanding Society Scientific Group
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- 2018
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181. Proximity to Traffic: Inflammation, and Immune Function among Women in the Seattle, Washington, Area
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Williams, Lori A., Ulrich, Cornelia M., Larson, Timothy, Wener, Mark H., Wood, Brent, Campbell, Peter T., Potter, John D., McTiernan, Anne, and De Roos, Anneclaire J.
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- 2009
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182. Exogenous Hormones and Colorectal Cancer Risk in Canada: Associations Stratified by Clinically Defined Familial Risk of Cancer
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Campbell, Peter T., Newcomb, Polly, Gallinger, Steven, Cotterchio, Michelle, and McLaughlin, John R.
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- 2007
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183. Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region
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Jordahl, Kristina M., primary, Shcherbina, Anna, additional, Kim, Andre E., additional, Su, Yu-Ru, additional, Lin, Yi, additional, Wang, Jun, additional, Qu, Conghui, additional, Albanes, Demetrius, additional, Arndt, Volker, additional, Baurley, James W., additional, Berndt, Sonja I., additional, Bien, Stephanie A., additional, Bishop, D. Timothy, additional, Bouras, Emmanouil, additional, Brenner, Hermann, additional, Buchanan, Daniel D., additional, Budiarto, Arif, additional, Campbell, Peter T., additional, Carreras-Torres, Robert, additional, Casey, Graham, additional, Cenggoro, Tjeng Wawan, additional, Chan, Andrew T., additional, Conti, David V., additional, Dampier, Christopher H., additional, Devall, Matthew A., additional, Díez-Obrero, Virginia, additional, Dimou, Niki, additional, Drew, David A., additional, Figueiredo, Jane C., additional, Gallinger, Steven, additional, Giles, Graham G., additional, Gruber, Stephen B., additional, Gsur, Andrea, additional, Gunter, Marc J., additional, Hampel, Heather, additional, Harlid, Sophia, additional, Harrison, Tabitha A., additional, Hidaka, Akihisa, additional, Hoffmeister, Michael, additional, Huyghe, Jeroen R., additional, Jenkins, Mark A., additional, Joshi, Amit D., additional, Keku, Temitope O., additional, Larsson, Susanna C., additional, Le Marchand, Loic, additional, Lewinger, Juan Pablo, additional, Li, Li, additional, Mahesworo, Bharuno, additional, Moreno, Victor, additional, Morrison, John L., additional, Murphy, Neil, additional, Nan, Hongmei, additional, Nassir, Rami, additional, Newcomb, Polly A., additional, Obón-Santacana, Mireia, additional, Ogino, Shuji, additional, Ose, Jennifer, additional, Pai, Rish K., additional, Palmer, Julie R., additional, Papadimitriou, Nikos, additional, Pardamean, Bens, additional, Peoples, Anita R., additional, Pharoah, Paul D.P., additional, Platz, Elizabeth A., additional, Potter, John D., additional, Prentice, Ross L., additional, Rennert, Gad, additional, Ruiz-Narvaez, Edward, additional, Sakoda, Lori C., additional, Scacheri, Peter C., additional, Schmit, Stephanie L., additional, Schoen, Robert E., additional, Slattery, Martha L., additional, Stern, Mariana C., additional, Tangen, Catherine M., additional, Thibodeau, Stephen N., additional, Thomas, Duncan C., additional, Tian, Yu, additional, Tsilidis, Konstantinos K., additional, Ulrich, Cornelia M., additional, van Duijnhoven, Franzel J.B., additional, Van Guelpen, Bethany, additional, Visvanathan, Kala, additional, Vodicka, Pavel, additional, White, Emily, additional, Wolk, Alicja, additional, Woods, Michael O., additional, Wu, Anna H., additional, Zemlianskaia, Natalia, additional, Chang-Claude, Jenny, additional, Gauderman, W. James, additional, Hsu, Li, additional, Kundaje, Anshul, additional, and Peters, Ulrike, additional
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- 2022
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184. Biomarkers of Glucose Homeostasis and Inflammation with Risk of Prostate Cancer: A Case–Cohort Study
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Wang, Ying, primary, Gapstur, Susan M., additional, Newton, Christina C., additional, McCullough, Marjorie L., additional, Pollak, Michael N., additional, and Campbell, Peter T., additional
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- 2022
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185. Genetic variants associated with circulating C‐reactive protein levels and colorectal cancer survival: Sex‐specific and lifestyle factors specific associations
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Huang, Yuhan, primary, Hua, Xinwei, additional, Labadie, Julia D., additional, Harrison, Tabitha A., additional, Dai, James Y., additional, Lindstrom, Sara, additional, Lin, Yi, additional, Berndt, Sonja I., additional, Buchanan, Daniel D., additional, Campbell, Peter T., additional, Casey, Graham, additional, Gallinger, Steven J., additional, Gunter, Marc J., additional, Hoffmeister, Michael, additional, Jenkins, Mark A., additional, Sakoda, Lori C., additional, Schoen, Robert E., additional, Diergaarde, Brenda, additional, Slattery, Martha L., additional, White, Emily, additional, Giles, Graham, additional, Brenner, Hermann, additional, Chang‐Claude, Jenny, additional, Joshi, Amit, additional, Ma, Wenjie, additional, Pai, Rish K., additional, Chan, Andrew T., additional, Peters, Ulrike, additional, and Newcomb, Polly A., additional
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- 2022
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186. Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study
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Archambault, Alexi N, primary, Jeon, Jihyoun, additional, Lin, Yi, additional, Thomas, Minta, additional, Harrison, Tabitha A, additional, Bishop, D Timothy, additional, Brenner, Hermann, additional, Casey, Graham, additional, Chan, Andrew T, additional, Chang-Claude, Jenny, additional, Figueiredo, Jane C, additional, Gallinger, Steven, additional, Gruber, Stephen B, additional, Gunter, Marc J, additional, Guo, Feng, additional, Hoffmeister, Michael, additional, Jenkins, Mark A, additional, Keku, Temitope O, additional, Le Marchand, Loïc, additional, Li, Li, additional, Moreno, Victor, additional, Newcomb, Polly A, additional, Pai, Rish, additional, Parfrey, Patrick S, additional, Rennert, Gad, additional, Sakoda, Lori C, additional, Lee, Jeffrey K, additional, Slattery, Martha L, additional, Song, Mingyang, additional, Win, Aung Ko, additional, Woods, Michael O, additional, Murphy, Neil, additional, Campbell, Peter T, additional, Su, Yu-Ru, additional, Lansdorp-Vogelaar, Iris, additional, Peterse, Elisabeth F P, additional, Cao, Yin, additional, Zeleniuch-Jacquotte, Anne, additional, Liang, Peter S, additional, Du, Mengmeng, additional, Corley, Douglas A, additional, Hsu, Li, additional, Peters, Ulrike, additional, and Hayes, Richard B, additional
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- 2022
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187. Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival
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Labadie, Julia D., primary, Savas, Sevtap, additional, Harrison, Tabitha A., additional, Banbury, Barb, additional, Huang, Yuhan, additional, Buchanan, Daniel D., additional, Campbell, Peter T., additional, Gallinger, Steven J., additional, Giles, Graham G., additional, Gunter, Marc J., additional, Hoffmeister, Michael, additional, Hsu, Li, additional, Jenkins, Mark A., additional, Lin, Yi, additional, Ogino, Shuji, additional, Phipps, Amanda I., additional, Slattery, Martha L., additional, Steinfelder, Robert S., additional, Sun, Wei, additional, Van Guelpen, Bethany, additional, Hua, Xinwei, additional, Figuieredo, Jane C., additional, Pai, Rish K., additional, Nassir, Rami, additional, Qi, Lihong, additional, Chan, Andrew T., additional, Peters, Ulrike, additional, and Newcomb, Polly A., additional
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- 2022
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188. Molecular and Pathology Features of Colorectal Tumors and Patient Outcomes Are Associated with Fusobacterium nucleatum and Its Subspecies animalis
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Borozan, Ivan, primary, Zaidi, Syed H., additional, Harrison, Tabitha A., additional, Phipps, Amanda I., additional, Zheng, Jiayin, additional, Lee, Stephen, additional, Trinh, Quang M., additional, Steinfelder, Robert S., additional, Adams, Jeremy, additional, Banbury, Barbara L., additional, Berndt, Sonja I., additional, Brezina, Stefanie, additional, Buchanan, Daniel D., additional, Bullman, Susan, additional, Cao, Yin, additional, Farris, Alton B., additional, Figueiredo, Jane C., additional, Giannakis, Marios, additional, Heisler, Lawrence E., additional, Hopper, John L., additional, Lin, Yi, additional, Luo, Xuemei, additional, Nishihara, Reiko, additional, Mardis, Elaine R., additional, Papadopoulos, Nickolas, additional, Qu, Conghui, additional, Reid, Emma E.G., additional, Thibodeau, Stephen N., additional, Harlid, Sophia, additional, Um, Caroline Y., additional, Hsu, Li, additional, Gsur, Andrea, additional, Campbell, Peter T., additional, Gallinger, Steven, additional, Newcomb, Polly A., additional, Ogino, Shuji, additional, Sun, Wei, additional, Hudson, Thomas J., additional, Ferretti, Vincent, additional, and Peters, Ulrike, additional
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- 2022
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189. Type 2 Diabetes and Risk of Early-Onset Colorectal Cancer
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Li, Zitong, primary, Chen, Hanyu, additional, Fritz, Cassandra D.L., additional, Zheng, Xiaobin, additional, Zong, Xiaoyu, additional, Nickel, Katelin B., additional, Tipping, Andrew, additional, Nguyen, Long H., additional, Chan, Andrew T., additional, Giovannucci, Edward L., additional, Colditz, Graham A., additional, Olsen, Margaret A., additional, Campbell, Peter T., additional, Davidson, Nicholas O., additional, Fields, Ryan C., additional, and Cao, Yin, additional
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- 2022
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190. Interactions Between Folate Intake and Genetic Predictors of Gene Expression Levels Associated with Colorectal Cancer Risk
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Haas, Cameron B., primary, Su, Yu-Ru, additional, Petersen, Paneen, additional, Wang, Xiaoliang, additional, Bien, Stephanie A, additional, Lin, Yi, additional, Albanes, Demetrius, additional, Weinstein, Stephanie J, additional, Jenkins, Mark A, additional, Figueiredo, Jane C, additional, Newcomb, Polly A, additional, Casey, Graham, additional, Marchand, Loic Le, additional, Campbell, Peter T, additional, Peters, Ulrike, additional, Hsu, Li, additional, Moreno, Victor, additional, Potter, John D, additional, Sakoda, Lori C, additional, Slattery, Martha L, additional, Chan, Andrew T, additional, Li, Li, additional, Giles, Graham G, additional, Milne, Roger L, additional, Gruber, Stephen B, additional, Rennert, Gad, additional, Woods, Michael O, additional, Gallinger, Steven J, additional, Berndt, Sonja, additional, Hayes, Richard B, additional, Huang, Wen-Yi, additional, Wolk, Alicja, additional, White, Emily, additional, Nan, Hongmei, additional, Nassir, Rami, additional, Lindor, Noralane M, additional, Lewinger, Juan P, additional, Kim, Andrew E, additional, Conti, David, additional, Gauderman, W. James, additional, and Buchanan, Daniel D, additional
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- 2021
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191. Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults
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Moore, Steven C., Lee, I-Min, Weiderpass, Elisabete, Campbell, Peter T., Sampson, Joshua N., Kitahara, Cari M., Keadle, Sarah K., Arem, Hannah, Berrington de Gonzalez, Amy, Hartge, Patricia, Adami, Hans-Olov, Blair, Cindy K., Borch, Kristin B., Boyd, Eric, Check, David P., Fournier, Agnès, Freedman, Neal D., Gunter, Marc, Johannson, Mattias, Khaw, Kay-Tee, Linet, Martha S., Orsini, Nicola, Park, Yikyung, Riboli, Elio, Robien, Kim, Schairer, Catherine, Sesso, Howard, Spriggs, Michael, Van Dusen, Roy, Wolk, Alicja, Matthews, Charles E., and Patel, Alpa V.
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- 2016
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192. Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.
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Papadimitriou, Nikos, Bull, Caroline J., Jenab, Mazda, Hughes, David J., Bell, Joshua A., Sanderson, Eleanor, Timpson, Nicholas J., Smith, George Davey, Albanes, Demetrius, Campbell, Peter T., Küry, Sébastien, Le Marchand, Loic, Ulrich, Cornelia M., Visvanathan, Kala, Figueiredo, Jane C., Newcomb, Polly A., Pai, Rish K., Peters, Ulrike, Tsilidis, Kostas K., and Boer, Jolanda M. A.
- Subjects
COLORECTAL cancer ,DISEASE risk factors ,GENOME-wide association studies ,BODY size ,COLON cancer - Abstract
Background: Observational studies have linked childhood obesity with elevated risk of colorectal cancer; however, it is unclear if this association is causal or independent from the effects of obesity in adulthood on colorectal cancer risk. Methods: We conducted Mendelian randomization (MR) analyses to investigate potential causal relationships between self-perceived body size (thinner, plumper, or about average) in early life (age 10) and measured body mass index in adulthood (mean age 56.5) with risk of colorectal cancer. The total and independent effects of body size exposures were estimated using univariable and multivariable MR, respectively. Summary data were obtained from a genome-wide association study of 453,169 participants in UK Biobank for body size and from a genome-wide association study meta-analysis of three colorectal cancer consortia of 125,478 participants. Results: Genetically predicted early life body size was estimated to increase odds of colorectal cancer (odds ratio [OR] per category change: 1.12, 95% confidence interval [CI]: 0.98–1.27), with stronger results for colon cancer (OR: 1.16, 95% CI: 1.00–1.35), and distal colon cancer (OR: 1.25, 95% CI: 1.04–1.51). After accounting for adult body size using multivariable MR, effect estimates for early life body size were attenuated towards the null for colorectal cancer (OR: 0.97, 95% CI: 0.77–1.22) and colon cancer (OR: 0.97, 95% CI: 0.76–1.25), while the estimate for distal colon cancer was of similar magnitude but more imprecise (OR: 1.27, 95% CI: 0.90–1.77). Genetically predicted adult life body size was estimated to increase odds of colorectal (OR: 1.27, 95% CI: 1.03, 1.57), colon (OR: 1.32, 95% CI: 1.05, 1.67), and proximal colon (OR: 1.57, 95% CI: 1.21, 2.05). Conclusions: Our findings suggest that the positive association between early life body size and colorectal cancer risk is likely due to large body size retainment into adulthood. [ABSTRACT FROM AUTHOR]
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- 2023
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193. Prospective Study Reveals Associations Between Colorectal Cancer and Type 2 Diabetes Mellitus or Insulin Use in Men
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Campbell, Peter T., Deka, Anusila, Jacobs, Eric J., Newton, Christina C., Hildebrand, Janet S., McCullough, Marjorie L., Limburg, Paul J., and Gapstur, Susan M.
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- 2010
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194. Re: Prediagnosis Body Mass Index, Physical Activity, and Mortality in Endometrial Cancer Patients
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Renehan, Andrew G., Crosbie, Emma J., and Campbell, Peter T.
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- 2014
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195. Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality
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Liu, Xing, primary, Yang, Wanshui, additional, Petrick, Jessica L., additional, Liao, Linda M., additional, Wang, Weibing, additional, He, Na, additional, Campbell, Peter T., additional, Zhang, Zuo-Feng, additional, Giovannucci, Edward, additional, McGlynn, Katherine A., additional, and Zhang, Xuehong, additional
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- 2021
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196. Salicylic acid and risk of colorectal cancer: a two sample Mendelian randomization study
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Nounu, Aayah, primary, Richmond, Rebecca C, additional, Stewart, Isobel D, additional, Surendran, Praveen, additional, Wareham, Nicholas J., additional, Butterworth, Adam, additional, Weinstein, Stephanie J, additional, Albanes, Demetrius, additional, Baron, John A, additional, Hopper, John L, additional, Figueiredo, Jane C, additional, Newcomb, Polly A, additional, Lindor, Noralane M, additional, Casey, Graham, additional, Platz, Elizabeth A, additional, Marchand, Loïc Le, additional, Ulrich, Cornelia M, additional, Li, Christopher I, additional, van Duijnhoven, Fränzel JB, additional, Gsur, Andrea, additional, Campbell, Peter T, additional, Moreno, Víctor, additional, Vodicka, Pavel, additional, Vodickova, Ludmila, additional, Amitay, Efrat, additional, Alwers, Elizabeth, additional, Chang-Claude, Jenny, additional, Sakoda, Lori C, additional, Slattery, Martha L, additional, Schoen, Robert E, additional, Gunter, Marc J, additional, Castellví-Bel, Sergi, additional, Kim, Hyeong Rok, additional, Kweon, Sun-Seog, additional, Chan, Andrew T, additional, Li, Li, additional, Zheng, Wei, additional, Bishop, D Timothy, additional, Buchanan, Daniel D, additional, Giles, Graham G, additional, Gruber, Stephen B, additional, Rennert, Gad, additional, Stadler, Zsofia K, additional, Harrison, Tabitha A, additional, Lin, Yi, additional, Keku, Temitope O, additional, Woods, Michael O, additional, Schafmayer, Clemens, additional, Van Guelpen, Bethany, additional, Gallinger, Steven, additional, Hampel, Heather, additional, Berndt, Sonja I, additional, Pharoah, Paul D P, additional, Lindblom, Annika, additional, Wolk, Alicja, additional, Wu, Anna H, additional, White, Emily, additional, Peters, Ulrike, additional, Drew, David A, additional, Scherer, Dominique, additional, Bermejo, Justo Lorenzo, additional, Brenner, Hermann, additional, Hoffmeister, Michael, additional, Williams, Ann C, additional, and Relton, Caroline L, additional
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- 2021
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197. Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies
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Julián-Serrano, Sachelly, primary, Yuan, Fangcheng, additional, Wheeler, William, additional, Benyamin, Beben, additional, Machiela, Mitchell J, additional, Arslan, Alan A, additional, Beane-Freeman, Laura E, additional, Bracci, Paige M, additional, Duell, Eric J, additional, Du, Mengmeng, additional, Gallinger, Steven, additional, Giles, Graham G, additional, Goodman, Phyllis J, additional, Kooperberg, Charles, additional, Marchand, Loic Le, additional, Neale, Rachel E, additional, Shu, Xiao-Ou, additional, Van Den Eeden, Stephen K, additional, Visvanathan, Kala, additional, Zheng, Wei, additional, Albanes, Demetrius, additional, Andreotti, Gabriella, additional, Ardanaz, Eva, additional, Babic, Ana, additional, Berndt, Sonja I, additional, Brais, Lauren K, additional, Brennan, Paul, additional, Bueno-de-Mesquita, Bas, additional, Buring, Julie E, additional, Chanock, Stephen J, additional, Childs, Erica J, additional, Chung, Charles C, additional, Fabiánová, Eleonora, additional, Foretová, Lenka, additional, Fuchs, Charles S, additional, Gaziano, J Michael, additional, Gentiluomo, Manuel, additional, Giovannucci, Edward L, additional, Goggins, Michael G, additional, Hackert, Thilo, additional, Hartge, Patricia, additional, Hassan, Manal M, additional, Holcátová, Ivana, additional, Holly, Elizabeth A, additional, Hung, Rayjean I, additional, Janout, Vladimir, additional, Kurtz, Robert C, additional, Lee, I-Min, additional, Malats, Núria, additional, McKean, David, additional, Milne, Roger L, additional, Newton, Christina C, additional, Oberg, Ann L, additional, Perdomo, Sandra, additional, Peters, Ulrike, additional, Porta, Miquel, additional, Rothman, Nathaniel, additional, Schulze, Matthias B, additional, Sesso, Howard D, additional, Silverman, Debra T, additional, Thompson, Ian M, additional, Wactawski-Wende, Jean, additional, Weiderpass, Elisabete, additional, Wenstzensen, Nicolas, additional, White, Emily, additional, Wilkens, Lynne R, additional, Yu, Herbert, additional, Zeleniuch-Jacquotte, Anne, additional, Zhong, Jun, additional, Kraft, Peter, additional, Li, Dounghui, additional, Campbell, Peter T, additional, Petersen, Gloria M, additional, Wolpin, Brian M, additional, Risch, Harvey A, additional, Amundadottir, Laufey T, additional, Klein, Alison P, additional, Yu, Kai, additional, and Stolzenberg-Solomon, Rachael Z, additional
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- 2021
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198. Weight Cycling and Cancer Incidence in a Large Prospective US Cohort
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Stevens, Victoria L., Jacobs, Eric J., Patel, Alpa V., Sun, Juzhong, McCullough, Marjorie L., Campbell, Peter T., and Gapstur, Susan M.
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- 2015
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199. Leisure Time Physical Activity and Mortality: A Detailed Pooled Analysis of the Dose-Response Relationship
- Author
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Arem, Hannah, Moore, Steven C., Patel, Alpa, Hartge, Patricia, Berrington de Gonzalez, Amy, Visvanathan, Kala, Campbell, Peter T., Freedman, Michal, Weiderpass, Elisabete, Adami, Hans Olov, Linet, Martha S., Lee, I.-Min, and Matthews, Charles E.
- Published
- 2015
- Full Text
- View/download PDF
200. Oxidative Balance Scores and Risk of Incident Colorectal Cancer in a US Prospective Cohort Study
- Author
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Dash, Chiranjeev, Bostick, Roberd M., Goodman, Michael, Flanders, W. Dana, Patel, Roshni, Shah, Roma, Campbell, Peter T., and McCullough, Marjorie L.
- Published
- 2015
- Full Text
- View/download PDF
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