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154. Additional file 1 of High body mass index is a significant risk factor for the progression and prognosis of imported COVID-19: a multicenter, retrospective cohort study

Author

Cai, Huan, Yang, Lisha, Yingfeng Lu, Shanyan Zhang, Chanyuan Ye, Xiaoli Zhang, Guodong Yu, Jueqing Gu, Jiangshan Lian, Shaorui Hao, Jianhua Hu, Yimin Zhang, Ciliang Jin, Jifang Sheng, Yida Yang, and Hongyu Jia

Abstract

Additional file 1: Table S1. Demographic and Epidemiological Characteristics of COVID-19 Patients with BMI ≥ 24. Data are presented as medians (interquartile ranges, IQR), n (%) and mean (SD).GI symptoms* include nausea, vomiting and diarrhea.

Published
2021
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155. Additional file 3 of High body mass index is a significant risk factor for the progression and prognosis of imported COVID-19: a multicenter, retrospective cohort study

Author

Cai, Huan, Yang, Lisha, Yingfeng Lu, Shanyan Zhang, Chanyuan Ye, Xiaoli Zhang, Guodong Yu, Jueqing Gu, Jiangshan Lian, Shaorui Hao, Jianhua Hu, Yimin Zhang, Ciliang Jin, Jifang Sheng, Yida Yang, and Hongyu Jia

Subjects
immune system diseases, virus diseases
Abstract

Additional file 3: Table S3. Treatments and outcomes of COVID-19 patients with BMI ≥ 24. Data are presented as medians (interquartile ranges, IQR), n (%) and mean (SD). Others* include interferon-α sprays, arbidol, and lopinavir/ritonavir monotherapy.

Published
2021
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156. Additional file 2 of High body mass index is a significant risk factor for the progression and prognosis of imported COVID-19: a multicenter, retrospective cohort study

Author

Cai, Huan, Yang, Lisha, Yingfeng Lu, Shanyan Zhang, Chanyuan Ye, Xiaoli Zhang, Guodong Yu, Jueqing Gu, Jiangshan Lian, Shaorui Hao, Jianhua Hu, Yimin Zhang, Ciliang Jin, Jifang Sheng, Yida Yang, and Hongyu Jia

Abstract

Additional file 2: Table S2. Radiographic and Laboratory Findings of COVID-19 Patients with BMI ≥ 24. Data are presented as medians (interquartile ranges, IQR), n (%) and mean (SD).

Published
2021
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158. Additional file 4 of High body mass index is a significant risk factor for the progression and prognosis of imported COVID-19: a multicenter, retrospective cohort study

Author

Cai, Huan, Yang, Lisha, Yingfeng Lu, Shanyan Zhang, Chanyuan Ye, Xiaoli Zhang, Guodong Yu, Jueqing Gu, Jiangshan Lian, Shaorui Hao, Jianhua Hu, Yimin Zhang, Ciliang Jin, Jifang Sheng, Yida Yang, and Hongyu Jia

Subjects
macromolecular substances
Abstract

Additional file 4: Table S4. Univariable Analysis of Risk Factors associated for the Severe/Critical type COVID-19 patients.

Published
2021
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160. Causal Effects of Sleep Traits on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study

Author

Cai,Huan, Liang,Jialin, Liu,Zhonghua, Fang,Liang, Zheng,Jinghong, Xu,Jiahe, Chen,Liyi, Sun,Wen, and Zhang,Hao

Subjects
Nature and Science of Sleep
Abstract

Huan Cai,1,* Jialin Liang,2,* Zhonghua Liu,1 Liang Fang,1 Jinghong Zheng,3 Jiahe Xu,3 Liyi Chen,1 Wen Sun,4 Hao Zhang5 1Department of Rehabilitation, Zhongshan City People’s Hospital, Zhongshan 528403, Guangdong, People’s Republic of China; 2Department of Endocrinology and Metabolism, Zhongshan City People’s Hospital, Zhongshan 528403, Guangdong, People’s Republic of China; 3Department of Neurology, Zhongshan City People’s Hospital, Zhongshan 528403, Guangdong, People’s Republic of China; 4Division of Life Sciences and Medicine, Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei 230026, Anhui, People’s Republic of China; 5Department of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao ZhangDepartment of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang, People’s Republic of ChinaTel +86-13450989238Fax +86 760-87727692Email zh_hao_neurol@163.comZhonghua LiuDepartment of Rehabilitation, Zhongshan City People’s Hospital, Zhongshan 528403, Guangdong, People’s Republic of ChinaTel 86-13923308898Email zhonghua_reha@163.comBackground: Unfavorable sleep habits have been linked with ischemic stroke in observational studies, but the causality remains unclear. The aim of this study is to investigate the potential causal role of three sleep traits, including sleep duration, insomnia, and chronotype, in ischemic stroke and its subtypes.Methods: We conducted two-sample Mendelian randomization (MR) analysis using single nucleotide polymorphisms associated with sleep duration, insomnia, and chronotype as instruments to estimate causal associations with ischemic stroke and its subtypes, among 34,217 ischemic stroke cases and 406,111 controls from the MEGASTROKE consortium. Inverse-variance weighted method was used as the main analyses. Alternative MR methods and sensitivity analyses were further performed.Results: We found suggestive evidence that per doubling of genetic liability for short sleep duration (odds ratio [OR], 1.27; 95% confidence interval [CI], 1.01– 1.58) and frequent insomnia symptoms (OR, 1.19; 95% CI, 1.00– 1.41) were associated with a modest increase in risk of large artery stroke (LAS) but not with small vessel stroke, cardioembolic stroke, or any ischemic stroke. The association of frequent insomnia symptoms with LAS was stronger after the exclusion of the outlier (OR, 1.25; 95% CI, 1.04– 1.50). No significant association was observed for chronotype with any ischemic stroke subtype. Results were overall robust to sensitivity analyses, and there was little evidence of horizontal pleiotropy.Conclusion: We provided suggestive evidence for a potential causal role of short sleep duration and insomnia symptoms in LAS. Future researches are required to investigate whether improved sleep habits could help to mitigate LAS risk.Keywords: sleep, large artery stroke, ischemic stroke, Mendelian randomization

Published
2020

163. Associations of GWAS-Supported Non-MHC Genes with Autoimmune Thyroiditis in Patients with Type 1 Diabetes

Author

Liang,Jialin, Liang,Ganxiong, Liu,Zhonghua, Cai,Huan, Liang,Jialin, Liang,Ganxiong, Liu,Zhonghua, and Cai,Huan

Abstract

Jialin Liang,1 Ganxiong Liang,1 Zhonghua Liu,2 Huan Cai2 1Department of Endocrinology and Metabolism, Zhongshan People’s Hospital, Zhongshan, 528403, Guangdong, People’s Republic of China; 2Department of Rehabilitation, Zhongshan People’s Hospital, Zhongshan, 528403, Guangdong, People’s Republic of ChinaCorrespondence: Ganxiong LiangDepartment of Endocrinology and Metabolism, Zhongshan People’s Hospital, 2 East Sunwen Road, Zhongshan, 528403, Guangdong, People’s Republic of ChinaTel +86-13392926029Email ganxiong_liang@126.comHuan CaiDepartment of Rehabilitation, Zhongshan People’s Hospital, 2 East Sunwen Road, Zhongshan, 528403, Guangdong, People’s Republic of ChinaTel +86-18718750210Email ch.neurol@gmail.comPurpose: A genome-wide association study (GWAS) in Caucasian population identified five non-MHC genes (PHTF1, PTPN22, MAGI3, BCL2L15, and QRFPR) associated with risk of the co-occurrence of autoimmune thyroid diseases (AITD) and type 1 diabetes (T1D). The aim of this study is to replicate these associations with AITD in patients with T1D in Chinese Han population.Patients and Methods: A case–control study was designed. Five single-nucleotide polymorphisms (SNPs) PHTF1 rs1111695, PTPN22 rs1217407, MAGI3 rs2153977, BCL2L15 rs2358994, and QRFPR rs7679475 were genotyped in 489 patients with T1D. Associations between genotypes and AITD risk were analyzed with logistic regression model.Results: AITD occurred in 159 (32.5%) patients. When adjusting multiple factors by logistic regression, QRFPR rs7679475 was significantly associated with an increased risk of AITD in T1D patients in codominant model (G/G vs A/A, OR 2.93; 95% CI 1.44– 5.96; P = 0.003), dominant model (G/A-G/G vs A/A, OR 1.81; 95% CI 1.17– 2.79; P = 0.007) and recessive model (G/G vs A/A-G/A, OR 2.28; 95% CI 1.17– 4.43; P = 0.015). Furthermore, we found a significant interaction between rs7679475 and female (P interaction = 0.005). In silico analysis indicated that rs7679475 is loc

Published
2021

170. Culture bovine prospermatogonia with 2i medium

Author

Cai, Huan, primary, Jiang, Yu, additional, Zhang, Sheng, additional, Cai, Ning‐Ning, additional, Zhu, Wen‐Qian, additional, Yang, Rui, additional, Tang, Bo, additional, Li, Zi‐Yi, additional, and Zhang, Xue‐Ming, additional

Published
2021
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172. Genetic variations and divergence of two Haliotis species as revealed by AFLP analysis

Author

Wang, Zhi Yong, Ke, Cai-Huan, Wang, Yi-Lei, Xiao, Zhi-Qun, Ho, Ka Chai, and Chu, Ka Hou

Subjects
Abalones -- Research -- Genetic aspects, Biological sciences, Zoology and wildlife conservation, Genetic aspects, Research
Abstract

ABSTRACT Amplified fragment length polymorphism (AFLP) technology was used to reveal genetic variations and divergence of Haliotis discus and H. diversicolor, the two economically important abalone species in China. Three [...]

Published
2004

173. Lack of genetic divergence in nuclear and mitochondrial DNA between subspecies of two Haliotis species

Author

Wang, Zhi Yong, Ho, Ka Chai, Yu, Da Hui, Ke, Cai Huan, Mak, Wai Yan, and Chu, Ka Hou

Subjects
Abalones -- Genetic aspects -- Research, Biological sciences, Zoology and wildlife conservation, Genetic aspects, Research
Abstract

ABSTRACT Haliotis discus and Haliotis diversicolor are economically important abalone species in northern and southern China, respectively. Two subspecies have been recognized for each species, namely, H. discus discus and [...]

Published
2004

177. Efficacy and safety of early anticoagulation in patients with acute ischemic stroke due to atrial fibrillation: a Meta-analysis

Author

WANG Yunxiang, QI Xuhui, CAI Huanhuan, and LU Zhibing

Subjects
atrial fibrillation, acute ischemic stroke, new oral anticoagulants, meta-analysis, early, Medicine
Abstract

Objective To evaluate the efficacy and safety of early use of new oral anticoagulants (≤3 days) in patients with acute ischemic stroke(AIS) due to atrial fibrillation (AF).Method After systematic retrieval of CNKI, WanFang Data, VIP, PubMed, The Cochrane Library and Embase database, clinical studies on early anticoagulation therapy for AF-related AIS patients were screened. The search was conducted from the time of database construction to November 4, 2022, while the references were searched manually. Literature screening, data extraction and quality assessment were performed independently by 2 investigators. Meta-analysis was performed using RevMan 5.4 software, and the combined dichotomous effect sizes were expressed as relative risk (RR) and 95% confidence interval (CI).Result A total of 2 randomized controlled trials and 5 non-randomized controlled trials including 2 226 patients were included, and the analysis suggested that early anticoagulation treatment (≤3 days) was similar to delayed anticoagulation (> 3 days) in terms of total ischemic events [RR=1.04, 95%CI(0.67, 1.61), P=0.88], recurrent ischemic strokes or transient ischemic attack [RR=0.88, 95%CI(0.58, 1.34), P=0.56], major bleeding [RR=1.24, 95%CI(0.59, 2.62), P=0.56], and symptomatic intracerebral haemorrhage [RR=0.98, 95%CI(0.44, 2.17), P=0.96]. In terms of total cerebral hemorrhages, the incidence was lower than in the delayed anticoagulation group.Conclusion Anticoagulation started early after the occurrence of atrial fibrillation related ischemic stroke is similar to delayed anticoagulation in terms of effectiveness, and does not increase the risk of bleeding in patients.

Published
2024
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182. High neutrophil-to-lymphocyte ratio associated with progression to critical illness in older patients with COVID-19: a multicenter retrospective study

Author

Lian, Jiangshan, primary, jin, Ciliang, additional, Hao, Shaorui, additional, Zhang, Xiaoli, additional, Yang, Meifang, additional, Jin, Xi, additional, Lu, Yingfeng, additional, Hu, Jianhua, additional, Zhang, Shanyan, additional, Zheng, Lin, additional, Jia, Hongyu, additional, Cai, Huan, additional, Zhang, Yimin, additional, Yu, Guodong, additional, Wang, Xiaoyan, additional, Gu, Jueqing, additional, Ye, Chanyuan, additional, Yu, Xiaopeng, additional, Gao, Jianguo, additional, Yang, Yida, additional, and Sheng, Jifang, additional

Published
2020
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183. Impact of comorbidities on patients with COVID‐19: A large retrospective study in Zhejiang, China

Author

Ye, Chanyuan, primary, Zhang, Shanyan, additional, Zhang, Xiaoli, additional, Cai, Huan, additional, Gu, Jueqing, additional, Lian, Jiangshan, additional, Lu, Yingfeng, additional, Jia, Hongyu, additional, Hu, Jianhua, additional, Jin, Ciliang, additional, Yu, Guodong, additional, Zhang, Yimin, additional, Sheng, Jifang, additional, and Yang, Yida, additional

Published
2020
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185. Liver Enzyme Elevation in Coronavirus Disease 2019: A Multicenter, Retrospective, Cross-Sectional Study

Author

Hao, Shao-Rui, primary, Zhang, Shan-Yan, additional, Lian, Jiang-Shan, additional, Jin, Xi, additional, Ye, Cheng-Yin, additional, Cai, Huan, additional, Zhang, Xiao-Li, additional, Hu, Jian-Hua, additional, Zheng, Lin, additional, Zhang, Yi-Min, additional, Jia, Hong-Yu, additional, Yu, Guo-Dong, additional, Wang, Xiao-Yan, additional, Gu, Jue-Qing, additional, Lu, Ying-Feng, additional, Yu, Xiao-Peng, additional, Yu, Liang, additional, Xiang, Dai-Rong, additional, Ye, Chan-Yuan, additional, Jin, Ci-Liang, additional, Qiu, Yun-Qing, additional, Li, Lan-Juan, additional, Sheng, Ji-Fang, additional, Liang, Ting-Bo, additional, and Yang, Yi-Da, additional

Published
2020
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186. Epidemiological, clinical, and virological characteristics of 465 hospitalized cases of coronavirus disease 2019 (COVID‐19) from Zhejiang province in China

Author

Lian, Jiangshan, primary, Jin, Xi, additional, Hao, Shaorui, additional, Jia, Hongyu, additional, Cai, Huan, additional, Zhang, Xiaoli, additional, Hu, Jianhua, additional, Zheng, Lin, additional, Wang, Xiaoyan, additional, Zhang, Shanyan, additional, Ye, Chanyuan, additional, Jin, Ciliang, additional, Yu, Guodong, additional, Gu, Jueqing, additional, Lu, Yingfeng, additional, Yu, Xiaopeng, additional, Xiang, Dairong, additional, Li, Lanjuan, additional, Liang, Tingbo, additional, Sheng, Jifang, additional, and Yang, Yida, additional

Published
2020
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188. Analysis of Epidemiological and Clinical Features in Older Patients With Coronavirus Disease 2019 (COVID-19) Outside Wuhan

Author

Lian, Jiangshan, primary, Jin, Xi, additional, Hao, Shaorui, additional, Cai, Huan, additional, Zhang, Shanyan, additional, Zheng, Lin, additional, Jia, Hongyu, additional, Hu, Jianhua, additional, Gao, Jianguo, additional, Zhang, Yimin, additional, Zhang, Xiaoli, additional, Yu, Guodong, additional, Wang, Xiaoyan, additional, Gu, Jueqing, additional, Ye, Chanyuan, additional, Jin, Ciliang, additional, Lu, Yingfeng, additional, Yu, Xia, additional, Yu, Xiaopeng, additional, Ren, Yue, additional, Qiu, Yunqing, additional, Li, Lanjuan, additional, Sheng, Jifang, additional, and Yang, Yida, additional

Published
2020
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189. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms

Author

Jin, Xi, primary, Lian, Jiang-Shan, additional, Hu, Jian-Hua, additional, Gao, Jianguo, additional, Zheng, Lin, additional, Zhang, Yi-Min, additional, Hao, Shao-Rui, additional, Jia, Hong-Yu, additional, Cai, Huan, additional, Zhang, Xiao-Li, additional, Yu, Guo-Dong, additional, Xu, Kai-Jin, additional, Wang, Xiao-Yan, additional, Gu, Jue-Qing, additional, Zhang, Shan-Yan, additional, Ye, Chan-Yuan, additional, Jin, Ci-Liang, additional, Lu, Ying-Feng, additional, Yu, Xia, additional, Yu, Xiao-Peng, additional, Huang, Jian-Rong, additional, Xu, Kang-Li, additional, Ni, Qin, additional, Yu, Cheng-Bo, additional, Zhu, Biao, additional, Li, Yong-Tao, additional, Liu, Jun, additional, Zhao, Hong, additional, Zhang, Xuan, additional, Yu, Liang, additional, Guo, Yong-Zheng, additional, Su, Jun-Wei, additional, Tao, Jing-Jing, additional, Lang, Guan-Jing, additional, Wu, Xiao-Xin, additional, Wu, Wen-Rui, additional, Qv, Ting-Ting, additional, Xiang, Dai-Rong, additional, Yi, Ping, additional, Shi, Ding, additional, Chen, Yanfei, additional, Ren, Yue, additional, Qiu, Yun-Qing, additional, Li, Lan-Juan, additional, Sheng, Jifang, additional, and Yang, Yida, additional

Published
2020
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194. Sap Flow Characteristics of Kiwifruit Tree and Its Response to Environmental Factors

Author

LI Zongyang, ZHAO Lu, XING Liwen, CUI Ningbo, and CAI Huanjie

Subjects
kiwifruit tree, sap flow, environmental factors, path analysis, time delay, Agriculture (General), S1-972, Irrigation engineering. Reclamation of wasteland. Drainage, TC801-978
Abstract

【Objective】 To explore the variation characteristics of kiwifruit sap flow and its response to environmental factors. 【Method】 The thermal diffusion pin-type sap flow meter was used to monitor the sap flow law of kiwifruit trees in Guanzhong Plain, and the relationship between the sap flow of kiwifruit tree and environmental factors was analyzed. 【Result】 The daily-scale sap flow of kiwifruit tree showed a significant single-peak change during the whole growth period. The maximum value was 11.00 cm/h, which appeared in the fruit expansion period, and the minimum value was 0.18 cm/h, which appeared in the leaf expansion period. The peak value of hourly-scale sap flow rate in each growth period was: fruit expansion period > fruit maturity period > flowering and fruit setting period>shoot expansion period. The peak value of sap flow rate under different weather conditions was: sunny day>cloudy day > rainy day. The daily average sap flow rate of fruit tree was significantly positively correlated with air temperature, water vapor pressure deficit and net solar radiation, and the correlation coefficients were 0.842, 0.749 and 0.713, respectively. The results of path analysis showed that the net solar radiation had the greatest direct effect on the sap flow of kiwifruit tree, and the soil volumetric water content mainly affected the plant sap flow through the combined effect of net solar radiation, air temperature and soil temperature. There is an obvious time lag effect between meteorological factors and liquid flow rate. The time lag between liquid flow rate and solar net radiation is -30 min, the time lag between liquid flow rate and humidity is 60 min, and the time lag between liquid flow rate and air temperature and water vapor pressure deficit is 90 min. 【Conclusion】 The transpiration and water consumption of kiwifruit tree during fruit expansion period were the largest, so attention should be paid to the soil water status of kiwifruit tree during this period. In sunny weather, the sap flow of kiwifruit tree is the largest from 12:00 to 16:00, and the evaporation is also large, so irrigation should be avoided in this time to reduce the irrigation loss caused by transpiration.

Published
2023
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195. CDKN2B Methylation and Aortic Arch Calcification in Patients with Ischemic Stroke

Author

Zhou, Shuyu, Cai, Biyang, Zhang, Zhizhong, Zhang, Yumeng, Wang, Li, Liu, Keting, Zhang, Hao, Sun, Lingli, Cai, Huan, Lu, Guangming, Liu, Xinfeng, and Xu, Gelin

Subjects
Male, China, Alcohol Drinking, Genotype, Computed Tomography Angiography, Aorta, Thoracic, Chromosomes, Brain Ischemia, Epigenesis, Genetic, Risk Factors, Humans, Promoter Regions, Genetic, Vascular Calcification, Aged, Cyclin-Dependent Kinase Inhibitor p15, Dyslipidemias, DNA methylation, Ischemic stroke, Smoking, Calcinosis, Middle Aged, Aortic arch calcification, Stroke, Hypertension, Linear Models, Original Article, CpG Islands, Female, CDKN2A/2B
Abstract

Aim: CDKN2A/2B near chromosome 9p21 has been proposed as a potential genetic etiology for both atherosclerosis and arterial calcification. DNA methylation, which can change the expression of CDKN2A/2B, may be an underlying mechanism for this association. This study aimed to evaluate whether CDKN2A/2B methylation is related to aortic arch calcification (AAC) in patients with ischemic stroke. Methods: DNA methylation levels of CDKN2A/2B was measured using venous blood samples in 322 patients with ischemic stroke. A total of 36 CpG sites around promoter regions of CDKN2A/2B were examined. AAC was quantified with Agatston score based on results of computed tomography angiography. Results: There were 248 (77.0%) patients with and 74 (23.0%) patients without evident AAC. Compared with patients without AAC, patients with AAC had higher methylation levels of CDKN2B (5.72 vs 4.94, P < 0.001). Using a generalized linear model, positive correlation between methylation levels and log-transformed calcification scores was detected at CDKN2B (β = 0.275 ± 0.116, P = 0.018). Conclusion: Patients with higher levels of DNA methylation of CDKN2B may bear increased risk for AAC. Further studies to reveal the underlying mechanisms of this association are warranted for establishing a cause–effect relationship.

Published
2017

200. Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories

Author

van Gastel, Jaana, primary, Cai, Huan, additional, Cong, Wei-Na, additional, Chadwick, Wayne, additional, Daimon, Caitlin, additional, Leysen, Hanne, additional, Hendrickx, Jhana O., additional, De Schepper, Robin, additional, Vangenechten, Laura, additional, Van Turnhout, Jens, additional, Verswyvel, Jasper, additional, Becker, Kevin G., additional, Zhang, Yongqing, additional, Lehrmann, Elin, additional, Wood, William H., additional, Martin, Bronwen, additional, and Maudsley, Stuart, additional

Published
2019
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