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1,703 results on '"CALOGERO, A. E."'

155. Omics sciences and precision medicine in prostate cancer.

Author

Medori, M. C., Micheletti, C., Gadler, M., Benedetti, S., Guerri, G., Cristofoli, F., Generali, D., Donofrio, C. A., Cominetti, M., Fioravanti, A., Riccio, L., Bernini, A., Fulcheri, E., Calogero, A. E., Cannarella, R., Stuppia, L., Gatta, V., Cecchin, S., Marceddu, G., and Bertelli, M.

Subjects
INDIVIDUALIZED medicine, PROSTATE cancer, METABOLOMICS, METABOLITES, HEALTH outcome assessment, BIOMARKERS
Abstract

In the last decade, Prostate Cancer (PCa) has emerged as the second most prevalent and serious medical condition, and is considered one of the leading factors contributing to global mortality rates. Several factors (genetic as well as environmental) contribute to its development and seriousness. Since the disease is usually asymptomatic at early stages, it is typically misdiagnosed or over-diagnosed by the diagnostic procedures currently in use, leading to improper treatment. Effective biomarkers and diagnostic techniques are desperately needed in clinical settings for better management of PCa patients. Studies integrating omics sciences have shown that the accuracy and dependability of diagnostic and prognostic evaluations have increased because of the use of omics data; also, the treatment plans using omics can be facilitated by personalized medicine. The present review emphasizes innovative multi-omics methodologies, encompassing proteomics, genomics, microbiomics, metabolomics, and transcriptomics, with the aim of comprehending the molecular alterations that trigger and contribute to PCa. The review shows how early genomic and transcriptomic research has made it possible to identify PCa-related genes that are controlled by tumorrelevant signaling pathways. Proteomic and metabolomic analyses have recently been integrated, advancing our understanding of the complex mechanisms at play, the multiple levels of regulation, and how they interact. By applying the omics approach, new vulnerabilities may be discovered, and customized treatments with improved efficacy will soon be accessible. [ABSTRACT FROM AUTHOR]

Published
2023
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156. Omics sciences and precision medicine in testicular cancer.

Author

Madeo, G., Bonetti, G., Maltese, P. E., Tanzi, B., Tezzele, S., Mareso, C., Agostini, F., Generali, D., Donofrio, C. A., Cominetti, M., Fioravanti, A., Riccio, L., Beccari, T., Ceccarini, M. R., Calogero, A. E., Cannarella, R., Stuppia, L., Gatta, V., Nughman, M., and Cecchin, S.

Subjects
INDIVIDUALIZED medicine, TESTICULAR cancer, DNA repair, DISEASE management, METABOLOMICS, BIOMARKERS
Abstract

Background. Cancer, a potentially fatal condition, is one of the leading causes of death worldwide. Among males aged 20 to 35, the most common cancer in healthy individuals is testicular cancer, accounting for 1% to 2% of all cancers in men. Methods. Throughout this review, we have employed a targeted research approach, carefully handpicking the most representative and relevant articles on the subject. Our methodology involved a systematic review of the scientific literature to ensure a comprehensive and accurate overview of the available sources. Results. The onset and spread of testicular cancer are significantly influenced by genetic changes, including mutations in oncogenes, tumor suppressor genes, and DNA repair genes. As a result of identifying these specific genetic mutations in cancers, targeted medications have been developed to disrupt the signaling pathways affected by these genetic changes. To improve the diagnosis and treatment of this disease, it is crucial to understand its natural and clinical histories. Conclusions. In order to comprehend cancer better and to discover new biomarkers and therapeutic targets, oncologists are increasingly employing omics methods, such as genomics, transcriptomics, proteomics, and metabolomics. Targeted medications that focus on specific genetic pathways and mutations hold promise for advancing the diagnosis and management of this disease. [ABSTRACT FROM AUTHOR]

Published
2023
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158. Effects of oral contraceptives on thyroid function and vice versa

Author

Torre, F., Calogero, A. E., Condorelli, R. A., Cannarella, R., Aversa, A., and La Vignera, S.

Abstract

Background: Thyroid gland dysfunction represents an epidemiologically relevant disease in the female gender, where treatment with oral contraceptives (OCs) is frequently prescribed. Although OCs are able to impact the thyroid gland function, scanty data have been released on this matter so far. Aim: The aim of this article was to review how hormonal OCs, including estrogen- or progesterone-only containing medications, interact with the hepatic production of thyroid-binding globulin (TBG) and, consequently, their effects on serum levels of thyroxine (T4) and triiodothyronine (T3). We also reviewed the effect of Levo-T4 (LT4) administration in women taking OCs and how they influence the thyroid function in both euthyroid women and in those receiving LT4. Review: The estrogenic component of the pills is capable of increasing various liver proteins, such as TBG, sex hormone-binding protein (SHBG) and coagulation factors. On the other hand, the role of progestogens is to modulate estrogen-dependent effects mainly through their anti-androgenic action. In fact, a reduction in the effects of androgens is useful to keep the thromboembolic and cardiovascular risks low, whereas OCs increase it especially in women with subclinical hypothyroidism or in those treated with LT4. Accordingly, subclinical hypothyroidism is known to be associated with a higher mean platelet volume than normal and this increases cardiovascular risk due to platelet hyperactivity caused by incomplete thrombocytopoietic maturation.

Published
2024
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161. Sperm-carried IGF2 downregulated the expression of mitogens produced by Sertoli cells: A paracrine mechanism for regulating spermatogenesis?

Author

Cannarella, Rossella, primary, Mancuso, Francesca, additional, Arato, Iva, additional, Lilli, Cinzia, additional, Bellucci, Catia, additional, Gargaro, Marco, additional, Curto, Roberto, additional, Aglietti, Maria C., additional, La Vignera, Sandro, additional, Condorelli, Rosita A., additional, Luca, Giovani, additional, and Calogero, Aldo E., additional

Published
2022
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165. The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: An overview on male genital tract ultrasound reference ranges

Author

Lotti, Francesco, primary, Frizza, Francesca, additional, Balercia, Giancarlo, additional, Barbonetti, Arcangelo, additional, Behre, Hermann M., additional, Calogero, Aldo E., additional, Cremers, Jann‐Frederik, additional, Francavilla, Felice, additional, Isidori, Andrea M., additional, Kliesch, Sabine, additional, La Vignera, Sandro, additional, Lenzi, Andrea, additional, Marcou, Marios, additional, Pilatz, Adrian, additional, Poolamets, Olev, additional, Punab, Margus, additional, Godoy, Maria Fernanda Peraza, additional, Quintian, Claudia, additional, Rajmil, Osvaldo, additional, Salvio, Gianmaria, additional, Shaeer, Osama, additional, Weidner, Wolfgang, additional, Maseroli, Elisa, additional, Cipriani, Sarah, additional, Baldi, Elisabetta, additional, Degl'Innocenti, Selene, additional, Danza, Giovanna, additional, Caldini, Anna Lucia, additional, Terreni, Alessandro, additional, Boni, Luca, additional, Krausz, Csilla, additional, and Maggi, Mario, additional

Published
2022
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166. SINGLE COMPOUND ANTIOXIDANTS ARE SIMILARLY EFFECTIVE AS MULTI-COMPOUND ANTIOXIDANTS OVER A 3-MONTH PERIOD IN MEN WITH IDIOPATHIC INFERTILITY: A SYSTEMATIC REVIEW AND META-ANALYSIS

Author

Cannarella, Rossella, primary, Agarwal, Ashok, additional, Saleh, Ramadan, additional, Kandil, Hussein, additional, Salvio, Gianmaria, additional, Boitrelle, Florence, additional, Kuroda, Shinnosuke, additional, Farkouh, Ala'A., additional, Harraz, Ahmed, additional, Rambhatla, Amarnath, additional, Calogero, Aldo E., additional, and Shah, Rupin, additional

Published
2022
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167. Resistance to Thyroid Hormones: A Case-Series Study

Author

Cannarella, Rossella, primary, Musmeci, Marco, additional, Garofalo, Vincenzo, additional, Timpanaro, Tiziana A., additional, Leone, Guido, additional, Caruso, Manuela, additional, Maltese, Paolo E., additional, Condorelli, Rosita A., additional, La Vignera, Sandro, additional, and Calogero, Aldo E., additional

Published
2022
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177. Mechanisms Suggesting a Relationship between Vitamin D and Erectile Dysfunction: An Overview.

Author

Crafa, Andrea, Cannarella, Rossella, Barbagallo, Federica, Leanza, Claudia, Palazzolo, Roberto, Flores, Hunter Ausley, La Vignera, Sandro, Condorelli, Rosita A., and Calogero, Aldo E.

Subjects
VITAMIN D, VITAMIN D receptors, IMPOTENCE, REACTIVE oxygen species, VITAMIN D deficiency
Abstract

Vitamin D deficiency (VDD) and erectile dysfunction (ED) heavily burden the male population. The higher prevalence of both conditions in the elderly suggests a possible relationship between the two conditions. In addition, in vitro, animal, and human studies have revealed several mechanisms that may relate VDD to ED. The main mechanism by which vitamin D might exert its action on sexual function appears to be through the regulation of endothelial function. Indeed, VDD correlates with several markers of endothelial function. The action of vitamin D on the endothelium would be exercised both indirectly through its intervention in inflammatory processes and through the production of oxygen free radicals, and directly through the regulation of vascular stiffness, the production of nitric oxide, and the regulation of vessel permeability. Furthermore, the ubiquitous distribution of the vitamin D receptor in the human body means that this hormone can also exert a beneficial effect on erectile function by interfering with those comorbidities significantly associated with ED, such as hypertension, diabetes mellitus, hypercholesterolemia, chronic kidney disease, and hypogonadism. In this review, we thoroughly and carefully presented the evidence and mechanisms that would appear to relate vitamin D levels to erectile function. Furthermore, we have summarized the meta-analytic evidence for and against this association to provide a true representation of this topic. Data published to date suggest that low levels of vitamin D could contribute to worsening erectile function through several mechanisms. Therefore, vitamin D levels should be measured in patients with ED and maintained at adequate levels by specific supplementation in case of deficiency. However, the low quality and heterogeneity of clinical trials evaluating the effects of vitamin D administration on erectile function and ED-associated comorbidities do not allow for a univocal conclusion, and indicate the need for further studies to analyze these aspects. [ABSTRACT FROM AUTHOR]

Published
2023
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189. The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: Prostate‐vesicular transrectal ultrasound reference ranges and associations with clinical, seminal and biochemical characteristics

Author

Lotti, Francesco, primary, Frizza, Francesca, additional, Balercia, Giancarlo, additional, Barbonetti, Arcangelo, additional, Behre, Hermann M., additional, Calogero, Aldo E., additional, Cremers, Jann‐Frederik, additional, Francavilla, Felice, additional, Isidori, Andrea M., additional, Kliesch, Sabine, additional, La Vignera, Sandro, additional, Lenzi, Andrea, additional, Marcou, Marios, additional, Pilatz, Adrian, additional, Poolamets, Olev, additional, Punab, Margus, additional, Godoy, Maria Fernanda Peraza, additional, Quintian, Claudia, additional, Rajmil, Osvaldo, additional, Salvio, Gianmaria, additional, Shaeer, Osama, additional, Weidner, Wolfgang, additional, Maseroli, Elisa, additional, Cipriani, Sarah, additional, Baldi, Elisabetta, additional, Degl'Innocenti, Selene, additional, Danza, Giovanna, additional, Caldini, Anna Lucia, additional, Terreni, Alessandro, additional, Boni, Luca, additional, Krausz, Csilla, additional, and Maggi, Mario, additional

Published
2022
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195. Consensus and Diversity in the Management of Varicocele for Male Infertility:Results of a Global Practice Survey and Comparison with Guidelines and Recommendations

Author

Shah, Rupin, Agarwal, Ashok, Kavoussi, Parviz, Rambhatla, Amarnath, Saleh, Ramadan, Cannarella, Rossella, Harraz, Ahmed M., Boitrelle, Florence, Kuroda, Shinnosuke, Hamoda, Taha Abo Almagd Abdel Meguid, Zini, Armand, Ko, Edmund, Calik, Gokhan, Toprak, Tuncay, Kandil, Hussein, Gül, Murat, Bakırcıoğlu, Mustafa Emre, Parekh, Neel, Russo, Giorgio Ivan, Tadros, Nicholas, Kadioglu, Ates, Arafa, Mohamed, Chung, Eric, Rajmil, Osvaldo, Dimitriadis, Fotios, Malhotra, Vineet, Salvio, Gianmaria, Henkel, Ralf, Le, Tan V., Sogutdelen, Emrullah, Vij, Sarah, Alarbid, Abdullah, Gudeloglu, Ahmet, Tsujimura, Akira, Calogero, Aldo E., El Meliegy, Amr, Crafa, Andrea, Kalkanli, Arif, Baser, Aykut, Hazir, Berk, Giulioni, Carlo, Cho, Chak Lam, Ho, Christopher C.K., Salzano, Ciro, Zylbersztejn, Daniel Suslik, Tien, Dung Mai Ba, Pescatori, Edoardo, Fode, Mikkel, Jensen, Christian Fuglesang S., Sonksen, Jens, Shah, Rupin, Agarwal, Ashok, Kavoussi, Parviz, Rambhatla, Amarnath, Saleh, Ramadan, Cannarella, Rossella, Harraz, Ahmed M., Boitrelle, Florence, Kuroda, Shinnosuke, Hamoda, Taha Abo Almagd Abdel Meguid, Zini, Armand, Ko, Edmund, Calik, Gokhan, Toprak, Tuncay, Kandil, Hussein, Gül, Murat, Bakırcıoğlu, Mustafa Emre, Parekh, Neel, Russo, Giorgio Ivan, Tadros, Nicholas, Kadioglu, Ates, Arafa, Mohamed, Chung, Eric, Rajmil, Osvaldo, Dimitriadis, Fotios, Malhotra, Vineet, Salvio, Gianmaria, Henkel, Ralf, Le, Tan V., Sogutdelen, Emrullah, Vij, Sarah, Alarbid, Abdullah, Gudeloglu, Ahmet, Tsujimura, Akira, Calogero, Aldo E., El Meliegy, Amr, Crafa, Andrea, Kalkanli, Arif, Baser, Aykut, Hazir, Berk, Giulioni, Carlo, Cho, Chak Lam, Ho, Christopher C.K., Salzano, Ciro, Zylbersztejn, Daniel Suslik, Tien, Dung Mai Ba, Pescatori, Edoardo, Fode, Mikkel, Jensen, Christian Fuglesang S., and Sonksen, Jens

Abstract

Purpose: Varicocele is a common problem among infertile men. Varicocele repair (VR) is frequently performed to improve semen parameters and the chances of pregnancy. However, there is a lack of consensus about the diagnosis, indications for VR and its outcomes. The aim of this study was to explore global practice patterns on the management of varicocele in the context of male infertility. Materials and Methods: Sixty practicing urologists/andrologists from 23 countries contributed 382 multiple-choice-questions pertaining to varicocele management. These were condensed into an online questionnaire that was forwarded to clinicians involved in male infertility management through direct invitation. The results were analyzed for disagreement and agreement in practice patterns and, compared with the latest guidelines of international professional societies (American Urological Association [AUA], American Society for Reproductive Medicine [ASRM], and European Association of Urology [EAU]), and with evidence emerging from recent systematic reviews and meta-analyses. Additionally, an expert opinion on each topic was provided based on the consensus of 16 experts in the field. Results: The questionnaire was answered by 574 clinicians from 59 countries. The majority of respondents were urologists/uro-andrologists. A wide diversity of opinion was seen in every aspect of varicocele diagnosis, indications for repair, choice of technique, management of sub-clinical varicocele and the role of VR in azoospermia. A significant proportion of the responses were at odds with the recommendations of AUA, ASRM, and EAU. A large number of clinical situations were identified where no guidelines are available. Conclusions: This study is the largest global survey performed to date on the clinical management of varicocele for male infertility. It demonstrates: 1) a wide disagreement in the approach to varicocele management, 2) large gaps in the clinical practice guidelines from professional so

Published
2022

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