181 results on '"Buratto E"'
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152. Mitral repair in children with connective tissue disorders: On the edge, over the edge, or edge-to-edge?
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Buratto E, Ye XT, and Konstantinov IE
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- Child, Connective Tissue, Humans, Mitral Valve, Cardiac Surgical Procedures, Mitral Valve Insufficiency
- Published
- 2017
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153. Long-term outcomes of single-ventricle palliation for unbalanced atrioventricular septal defects: Fontan survivors do better than previously thought.
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Buratto E, Ye XT, King G, Shi WY, Weintraub RG, d'Udekem Y, Brizard CP, and Konstantinov IE
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- Adolescent, Australia epidemiology, Child, Child, Preschool, Echocardiography, Female, Follow-Up Studies, Heart Septal Defects diagnosis, Heart Septal Defects mortality, Heart Ventricles abnormalities, Heart Ventricles diagnostic imaging, Humans, Infant, Male, Palliative Care, Retrospective Studies, Risk Factors, Survival Rate trends, Treatment Outcome, Young Adult, Abnormalities, Multiple, Fontan Procedure methods, Forecasting, Heart Septal Defects surgery, Heart Ventricles surgery, Risk Assessment
- Abstract
Background: Single-ventricle palliation (SVP) for children with unbalanced atrioventricular septal defect (uAVSD) is thought to carry a poor prognosis, but limited data have been reported., Methods: We performed a retrospective review of children with uAVSD who underwent SVP at a single institution. Data were obtained from medical records and correspondence with general practitioners and cardiologists., Results: Between 1976 and 2016, a total of 139 patients underwent SVP for uAVSD. A neonatal palliative procedure was performed in 83.5% of these patients (116 of 139), and early mortality occurred in 11.2% (13 of 116). Ninety-four patients underwent stage II palliation, with an early mortality of 6.4% (6 of 94). Eighty patients (57.6%) underwent Fontan completion, with an early mortality of 3.8% (3 of 80). Interstage mortality was 11.7% (12 of 103) between stages I and II and 17.0% (15 of 88) between stage II and Fontan. Long-term survival was 66.5% (95% confidence interval [CI], 57.9%-73.9%) at 5 years, 64.4% (95% CI, 55.5%-72.0%) at 15 years, and 57.8% (95% CI, 47.5%-66.8%) at 25 years. Survival post-Fontan was 94.9% (95% CI, 86.9%-98.0%) at 5 years, 92.0% (95% CI, 80.6%-96.8%) at 15 years, and 82.4% (95% CI, 61.5%-92.6%) at 25 years. Risk factors associated with death or transplantation were aortic atresia (hazard ratio [HR], 5.3; P = .03) and hypoplastic aortic arch (HR, 2.5; P = .02). Atrioventricular valve operations were required in 31.7% of the patients (44 of 139), with 31.8% of them (14 of 44) requiring a further operation., Conclusions: Children undergoing SVP for uAVSD have substantial mortality, with <60% survival at 25 years. However, survival of children who achieve Fontan completion is better than has been reported previously., (Crown Copyright © 2016. Published by Elsevier Inc. All rights reserved.)
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- 2017
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154. Simple congenital heart disease: a complex challenge for public health.
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Buratto E, Ye XT, and Konstantinov IE
- Abstract
Competing Interests: The authors have no conflicts of interest to declare.
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- 2016
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155. Decellularized aortic conduits: could their cryopreservation affect post-implantation outcomes? A morpho-functional study on porcine homografts.
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Gallo M, Bonetti A, Poser H, Naso F, Bottio T, Bianco R, Paolin A, Franci P, Busetto R, Frigo AC, Buratto E, Spina M, Marchini M, Ortolani F, Iop L, and Gerosa G
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- Allografts, Animals, Aorta physiopathology, Aorta ultrastructure, Aortic Valve physiopathology, Aortic Valve ultrastructure, Blood Vessel Prosthesis Implantation adverse effects, Cell Proliferation, Echocardiography, Graft Survival, Heart Valve Prosthesis Implantation adverse effects, Hemodynamics, Microscopy, Electron, Transmission, Models, Animal, Postoperative Complications pathology, Postoperative Complications physiopathology, Swine, Time Factors, Aorta transplantation, Aortic Valve transplantation, Bioprosthesis, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation instrumentation, Cryopreservation, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation instrumentation
- Abstract
Decellularized porcine aortic valve conduits (AVCs) implanted in a Vietnamese Pig (VP) experimental animal model were matched against decellularized and then cryopreserved AVCs to assess the effect of cryopreservation on graft hemodynamic performance and propensity to in vivo repopulation by host's cells. VPs (n = 12) underwent right ventricular outflow tract substitution using AVC allografts and were studied for 15-month follow-up. VPs were randomized into two groups, receiving AVCs treated with decellularization alone (D; n = 6) or decellularization/cryopreservation (DC; n = 6), respectively. Serial echocardiography was carried out to follow up hemodynamic function. All explanted AVCs were processed for light and electron microscopy. No signs of dilatation, progressive stenosis, regurgitation, and macroscopic calcification were echocardiographically observed in both D and DC groups. Explanted D grafts exhibited near-normal features, whereas the presence of calcification, inflammatory infiltrates, and disarray of elastic lamellae occurred in some DC grafts. In the unaltered regions of AVCs from both groups, almost complete re-endothelialization was observed for both valve cusps and aorta walls. In addition, side-by-side repopulation by recipient's fibroblasts, myofibroblasts, and smooth muscle cells was paralleled by ongoing tissue remodeling, as revealed by the ultrastructural identification of typical canals of collagen fibrillogenesis and elastogenesis-related features. Incipient neo-vascularization and re-innervation of medial and adventitial tunicae of grafted aortic walls were also detected for both D and DC groups. Cryopreservation did not affect post-implantation AVC hemodynamic behavior and was topically propensive to cell repopulation and tissue renewal, although graft deterioration including calcification was present in several areas. Thus, these preliminary data provide essential information on feasibility of decellularization and cryopreservation coupling in the perspective of treatment optimization and subsequent clinical trials using similarly treated human allografts as innovative heart valve substitutes.
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- 2016
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156. Intramural ventricular septal defect after repair of conotruncal anomalies: Is there light at the end of the tunnel?
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Buratto E, Naimo PS, and Konstantinov IE
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- Humans, Transposition of Great Vessels, Double Outlet Right Ventricle, Heart Septal Defects, Ventricular
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- 2016
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157. Long-term outcomes of reoperations following repair of partial atrioventricular septal defect.
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Buratto E, Ye XT, Bullock A, Kelly A, d'Udekem Y, Brizard CP, and Konstantinov IE
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- Child, Female, Follow-Up Studies, Heart Septal Defects, Ventricular mortality, Humans, Male, Reoperation, Retrospective Studies, Survival Rate trends, Treatment Outcome, Victoria epidemiology, Cardiac Surgical Procedures methods, Forecasting, Heart Septal Defects, Ventricular surgery
- Abstract
Objectives: Partial atrioventricular septal defect (pAVSD) is repaired with excellent long-term survival. However, up to 25% of patients require reoperations. This study reviews results of reoperation following pAVSD repair at a single institution., Methods: From 1975 to 2012, 40 patients (16%, 40/246) underwent reoperation following pAVSD repair at the study institution. The data were retrospectively reviewed., Results: The mean time to reoperation was 5.4 ± 5.8 years. The most common reoperations were left atrioventricular valve (LAVV) surgery (78%, 31/40) and resection of left ventricular outflow tract obstruction (20%, 8/40). The most common cause for LAVV surgery was regurgitation through the cleft (58%, 18/31), followed by central regurgitation (29%, 9/31). Most cases of LAVV regurgitation were treated by repair (77%, 24/31), rather than replacement (23%, 7/31). Since the introduction of a patch augmentation technique for LAVV repair in 1998, the rate of repair has increased from 54 to 94% (P = 0.012). The early mortality rate was 2.5% (1/40). The survival rate was 90% (95% CI: 76-96) at 10 years and 83% (95% CI: 60-94) at 20 years. The rate of freedom from further reoperation was 66% (95% CI: 46-80) at 10- and 20-year follow-up., Conclusions: The most common cause for reoperation following pAVSD repair was LAVV regurgitation through the LAVV cleft. Reoperation is performed with survival comparable to that of primary pAVSD repair, yet the rate of further reoperations remains high. The patch augmentation technique for LAVVR has significantly increased the rate of successful LAVV repair., (© The Author 2016. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
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- 2016
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158. Actual application of virtual angioscopy: Is it yet to come?
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Naimo PS, Buratto E, and Konstantinov IE
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- Humans, User-Computer Interface, Angioscopy, Tomography, X-Ray Computed
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- 2016
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159. An intima affair adds to the dominion of the internal thoracic artery in coronary artery bypass grafting.
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Buratto E, Shi WY, and Konstantinov IE
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- Coronary Angiography, Humans, Internal Mammary-Coronary Artery Anastomosis, Treatment Outcome, Coronary Artery Bypass, Mammary Arteries transplantation
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- 2016
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160. The Pearls and Perils of Settling Scores in Public.
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Buratto E, Shi WY, and Konstantinov IE
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- 2016
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161. Cardiopulmonary exercise testing responses to different external portable drivers in a patient with a CardioWest Total Artificial Heart.
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Tarzia V, Braccioni F, Bortolussi G, Buratto E, Gallo M, Bottio T, Vianello A, and Gerosa G
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- Heart Transplantation, Humans, Male, Middle Aged, Exercise Test, Heart Failure surgery, Heart, Artificial, Prosthesis Failure
- Abstract
Management of patients treated with CardioWest Total Artificial Heart (CW-TAH) as a bridge to heart transplantation (HTx) is complicated by difficulties in determining the optimal timing of transplantation. We present a case of a 53-year-old man supported as an outpatient with a CW-TAH, whose condition deteriorated following exchange of the portable driver. The patient was followed-up with serial cardiopulmonary exercise testing (CPET) which demonstrated a fall of peak VO2 to below 12 ml/kg/min following driver substitution, and the patient was subsequently treated with urgent orthotopic HTx. This case highlights the potential utility of CPET as a means for monitoring and indicating timing of HTx in patients with CW-TAH, as well as the potential for clinical deterioration following portable driver substitution.
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- 2016
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162. From bench to bedside: Can the improvements in left ventricular assist device design mitigate adverse events and increase survival?
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Tarzia V, Di Giammarco G, Di Mauro M, Bortolussi G, Maccherini M, Tursi V, Maiani M, Bernazzali S, Marinelli D, Foschi M, Buratto E, Bejko J, Gregori D, Scuri S, Livi U, Sani G, Bottio T, and Gerosa G
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- Aged, Brain Ischemia epidemiology, Female, Heart Failure diagnosis, Heart Failure mortality, Heart Failure physiopathology, Hospital Mortality, Humans, Incidence, Intracranial Hemorrhages epidemiology, Italy epidemiology, Male, Middle Aged, Proportional Hazards Models, Prosthesis Design, Registries, Retrospective Studies, Risk Assessment, Risk Factors, Stroke epidemiology, Time Factors, Treatment Outcome, Ventricular Dysfunction, Right epidemiology, Heart Failure therapy, Heart-Assist Devices adverse effects, Ventricular Function, Left
- Abstract
Objective: In vitro tests demonstrated that the new cone-bearing configuration of the Jarvik 2000 (Jarvik Heart Inc, New York, NY) left ventricular assist device exhibits better hydraulic efficiency than the previous pin-bearing design. We investigated the long-term outcomes of patients who received the Jarvik 2000 left ventricular assist device, depending on bearing design., Methods: A retrospective review of prospectively collected data from 18 centers included in the Italian Registry was performed. From May 2008 to September 2013, 99 patients with end-stage heart failure were enrolled. Patients were divided into 2 groups according to their Jarvik 2000 suspending mechanism: Group pin included patients with pin bearings (May 2008 to June 2010), and group cone included patients with newer cone bearings (July 2010 to September 2013). The 2 groups did not differ significantly in terms of baseline characteristics., Results: A total of 30 of 39 patients (group pin) and 46 of 60 patients (group cone) were discharged. During follow-up, 6 patients underwent transplantation, and in 1 patient the left ventricular assist device was explanted. The cumulative incidence competing risk of the entire cohort for noncardiovascular-related death was 28% (20%-40%); the cumulative incidence competing risk for cardiovascular-related death was 56% (42%-73%): 71% in group pin versus 26% in group cone (P = .034). The multivariate analyses confirmed that the pin-bearing design was a risk factor for cardiovascular death, along with Interagency Registry for Mechanically Assisted Circulatory Support class. Right ventricular failures and ischemic and hemorrhagic strokes were significantly higher in group pin., Conclusions: Patients with the new pump configuration showed a better freedom from cardiovascular death and lower incidence of fatal stroke and right ventricular failure. Further studies are needed to prove the favorable impact of pump-enhanced fluid dynamics on long-term results., (Copyright © 2016 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.)
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- 2016
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163. Single vs double antiplatelet therapy in acute coronary syndrome: Predictors of bleeding after coronary artery bypass grafting.
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Tarzia V, Bortolussi G, Buratto E, Paolini C, Dal Lin C, Rizzoli G, Bottio T, and Gerosa G
- Abstract
Aim: To investigate the contribution of anti-platelet therapy and derangements of pre-operative classical coagulation and thromboelastometry parameters to major bleeding post-coronary artery bypass grafting (CABG)., Methods: Two groups of CABG patients were studied: Group A, treated with aspirin alone (n = 50), and Group B treated with aspirin and clopidogrel (n = 50). Both had similar preoperative, clinical, biologic characteristics and operative management. Classic coagulation parameters and rotational thromboelastometry (ROTEM) profiles were determined preoperatively for both groups and the same heparin treatment was administered. ROTEM profiles (INTEM and EXTEM assays) were analyzed, both for traditional parameters, and thrombin generation potential, expressed by area-under-curve (AUC)., Results: There was no significant difference between rates of major bleeding between patients treated with aspirin alone, compared with those treated with aspirin and clopidogrel (12% vs 16%, P = 0.77). In the 14 cases of major bleeding, pre-operative classic coagulation and traditional ROTEM parameters were comparable. Conversely we observed that the AUC in the EXTEM test was significantly lower in bleeders (5030 ± 1115 Ohm*min) than non-bleeders (6568 ± 548 Ohm*min) (P < 0.0001)., Conclusion: We observed that patients with a low AUC value were at a significantly higher risk of bleeding compared to patients with higher AUC, regardless of antiplatelet treatment. This suggests that thrombin generation potential, irrespective of the degree of platelet inhibition, correlates with surgical bleeding.
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- 2015
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164. Extracorporeal life support in cardiogenic shock: Impact of acute versus chronic etiology on outcome.
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Tarzia V, Bortolussi G, Bianco R, Buratto E, Bejko J, Carrozzini M, De Franceschi M, Gregori D, Fichera D, Zanella F, Bottio T, and Gerosa G
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- Acute Disease, Adult, Aged, Chronic Disease, Female, Heart Transplantation, Heart-Assist Devices, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Shock, Cardiogenic diagnosis, Shock, Cardiogenic etiology, Shock, Cardiogenic mortality, Shock, Cardiogenic physiopathology, Time Factors, Treatment Outcome, Ventricular Function, Left, Extracorporeal Circulation adverse effects, Extracorporeal Circulation mortality, Shock, Cardiogenic therapy
- Abstract
Background: The role of extracorporeal life support (ECLS) in primary cardiogenic shock (PCS) is well established. In this study, we evaluated the impact of etiology on outcomes., Methods: Between January 2009 and March 2013, we implanted a total of 249 patients with ECLS; we focused on 64 patients for whom peripheral ECLS was the treatment for PCS. Of these, 37 cases (58%) were "acute" (mostly acute myocardial infarction: 39%); 27 (42%) had an exacerbation of "chronic" heart failure (dilated cardiomyopathy: 30%; post-ischemic cardiomyopathy: 9%; and congenital: 3%)., Results: In the group with chronic etiology, 23 patients were bridged to a left ventricular assist device (52%) or heart transplantation (33%). In the group with acute etiology, ECLS was used as a bridge-to-transplantation in 3 patients (8%), a bridge-to-bridge in 9 (24%), and a bridge-to-recovery in 18 (49%). One patient in each group was bridged to conventional surgery. Recovery of cardiac function was achieved in only the group with acute primary cardiogenic shock (18 vs 0 patients, P = .0001). A mean flow during support of ≤60% of the theoretic flow (body surface area × 2.4) was a predictor of successful weaning (P = .02). Median duration of ECLS support was 7 days (range: 2-11.5 days). Nine patients (14%) died during support; 30-day overall survival was 80% (51 of 64 patients); and 59% of patients were discharged, in whom survival at 48 months was 90%. Thirty-day survival was correlated with duration of ECLS support., Conclusions: In "chronic" heart failure, ECLS represents a bridge to a ventricular assist device or heart transplantation, whereas in "acute" settings, it offers a considerable chance of recovery, and is often the only required therapy., (Copyright © 2015 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.)
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- 2015
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165. Repair of partial atrioventricular septal defect: a 37-year experience.
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Buratto E, McCrossan B, Galati JC, Bullock A, Kelly A, d'Udekem Y, Brizard CP, and Konstantinov IE
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- Adolescent, Child, Child, Preschool, Female, Follow-Up Studies, Heart Septal Defects, Ventricular mortality, Humans, Infant, Male, New South Wales epidemiology, Retrospective Studies, Survival Rate trends, Cardiac Surgical Procedures methods, Forecasting, Heart Septal Defects, Ventricular surgery, Postoperative Complications epidemiology, Registries
- Abstract
Objectives: Partial atrioventricular septal defect (pAVSD) is routinely repaired with a low mortality. However, limited data are available on the long-term follow-up of these patients. The current study was designed to determine long-term survival and morbidity of a large cohort of patients operated on at a single institution., Methods: From 1975 to 2012, 249 consecutive patients underwent pAVSD repair at the Royal Children's Hospital. The follow-up data were obtained from hospital records, correspondence with cardiologists and primary care physicians, patient surveys and the state death registry., Results: The early mortality rate was 1.2% (3/249), while the long-term survival rate was 96% (95% CI: 93-98%) at 10 years and 94% (95% CI: 89-97%) at 30 years. Freedom from reoperation was 84% at 10 years and 75% at 30 years. The most common reoperations were left atrioventricular valve surgery (30/249, 12.1%), resection of left ventricular outflow tract obstruction (12/249, 4.8%) and closure of residual atrial septal defects (5/249, 2.0%). Implantation of a permanent pacemaker was required in 3.2% (8/249) of patients. Despite a substantial reoperation rate, only 43% of patients older than 18 years of age were seen by a cardiologist within the most recent 2 years of the study period, compared with 80% of those younger than 18 years (P < 0.001)., Conclusions: Repair of pAVSD is performed with a low mortality and excellent long-term survival. However, a substantial reoperation rate warrants close follow-up into adulthood., (© The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
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- 2015
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166. The danger of using a sledgehammer to crack a nut: ROTEM-guided administration of recombinant activated factor VII in a patient with refractory bleeding post-ventricular assist device implantation.
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Tarzia V, Buratto E, Bortolussi G, Paolini C, Bejko J, Bottio T, and Gerosa G
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- Dose-Response Relationship, Drug, Drug Administration Schedule, Factor VIIa adverse effects, Follow-Up Studies, Hemostatics administration & dosage, Hemostatics adverse effects, Humans, Infusions, Intravenous, Male, Middle Aged, Myocarditis complications, Myocarditis pathology, Postoperative Hemorrhage etiology, Postoperative Hemorrhage physiopathology, Recombinant Proteins administration & dosage, Recombinant Proteins adverse effects, Recurrence, Risk Assessment, Severity of Illness Index, Shock, Cardiogenic etiology, Thrombelastography methods, Thrombosis prevention & control, Treatment Outcome, Factor VIIa administration & dosage, Heart-Assist Devices adverse effects, Postoperative Hemorrhage drug therapy, Shock, Cardiogenic surgery, Thrombelastography instrumentation
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Recombinant activated factor VII (rFVIIa) is currently approved for treating or preventing hemorrhage in patients with hemophilia, Glanzmann's thrombasthenia, or congenital FVII deficiency. Its "off-label" use for massive bleeding in the setting of trauma or surgery has been increasing because of demonstrated efficacy. However, the use of rFVIIa also carries a high thrombo-embolic risk. This is particularly true in cardiac surgery patients, especially those treated with mechanical circulatory support. We describe the case of a patient treated with a biventricular assist device in our center, in whom severe bleeding was treated in a targeted manner, using rotational thromboelastometry to guide administration and dosing of rFVIIa. A comprehensive review of the emerging literature on the use of rFVIIa postventricular assist device implantation accompanies the case to highlight the need for careful selection of prohemostatic agents in this high-risk group., (Copyright © 2014 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.)
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- 2015
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167. Surgical implantation of the CardioWest Total Artificial Heart.
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Tarzia V, Buratto E, Gallo M, Bortolussi G, Bejko J, Dal Lin C, Torregrossa G, Bianco R, Bottio T, and Gerosa G
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- 2014
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168. Hemorrhage and thrombosis with different LVAD technologies: a matter of flow?
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Tarzia V, Buratto E, Bortolussi G, Gallo M, Bejko J, Bianco R, Bottio T, and Gerosa G
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Background: Much of the morbidity and mortality associated with ventricular assist devices (VADs) is due to haemorrhagic and thrombotic complications. To manage antithrombotic therapy, interactions between the patient and pump should be better understood., Methods: We have compared the Jarvik 2000, an axial flow left ventricular assist device (LVAD), with the HeartWare ventricular assist device (HVAD) centrifugal pump, regarding conventional laboratory findings, thromboelastometric and aggregometric tests., Results: Patients with the Jarvik 2000 experienced a significant reduction in platelet count following implantation, a phenomenon not seen with the HeartWare model. Conversely, we observed that levels of platelet activation, as assessed by a platelet function analyzer, and activation of the coagulation system, as assessed by thromboelastometry, were significantly greater in the HeartWare group., Conclusions: It seems that axial flow pumps, being more destructive on blood cells, tend to reduce platelet numbers. On the other hand, centrifugal flow is associated with a hypercoagulable state, possibly resulting from the activation of the coagulation system in the absence of platelet destruction.
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- 2014
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169. Jarvik 2000: evolution of surgical implantation from conventional to minimally invasive technique.
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Tarzia V, Buratto E, Dal Lin C, Gallo M, Bortolussi G, Bejko J, Bottio T, and Gerosa G
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- 2014
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170. Implantation of the HeartWare HVAD: from full sternotomy to less invasive techniques.
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Tarzia V, Buratto E, Gallo M, Bortolussi G, Bejko J, Bianco R, Bottio T, and Gerosa G
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- 2014
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171. Predicting adverse outcomes in elective coronary artery bypass graft surgery using pre-operative troponin I levels.
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Buratto E, Conaglen P, Dimitriou J, Shan L, Yii MY, Rosalion A, Davis P, and Newcomb AE
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- Aged, Disease-Free Survival, Female, Follow-Up Studies, Humans, Male, Middle Aged, Survival Rate, Time Factors, Coronary Artery Bypass adverse effects, Databases, Factual, Elective Surgical Procedures adverse effects, Myocardial Ischemia blood, Myocardial Ischemia mortality, Myocardial Ischemia surgery, Preoperative Care, Troponin I blood
- Abstract
Background: Cardiac troponins are frequently measured as part of the pre-operative work-up of patients prior to coronary artery bypass graft surgery (CABG). The utility of measuring these levels in elective patients, and the clinical implication of an abnormal result are unclear. The following study investigates the relationship between cardiac troponin I (cTnI) measured as part of a routine pre-operative work-up and outcomes following CABG., Methods: From January 2010 to December 2012, 378 patients underwent isolated, elective CABG and had cTnI measured prospectively, as part of their pre-operative work-up. Patients were divided into normal (Group I) and elevated (Group II) cTnI groups. Pre-operative, operative and post-operative data were obtained from our institution's prospectively collected database., Results: Elevated cTnI was present in 47 patients (12.4%) pre-operatively. Intra-operative variables did not differ between the elevated cTnI and control groups. Both 30-day mortality (Group I: 0.9% v Group II: 6.4%, p=0.03) and cardiac arrest (Group I: 1.5% v Group II: 8.5%, p=0.01) were significantly more frequent in the elevated cTnI group. In multivariable analysis, elevated cTnI remained a predictor for cardiac arrest (OR 5.8, 95% CI 1.2 - 29.2)., Conclusions: Patients presenting for elective CABG frequently have elevated cTnI on pre-operative work-up. These patients may be at a greater risk of 30-day mortality and cardiac arrest. Routine pre-operative measurement of cTnI may alert clinicians to a higher operative risk., (Copyright © 2014 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.)
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- 2014
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172. Impact of vacuum-assisted closure therapy on outcomes of sternal wound dehiscence†.
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Tarzia V, Carrozzini M, Bortolussi G, Buratto E, Bejko J, Comisso M, Mescola V, Penzo V, Guarino M, De Franceschi M, Pagnin C, Castoro M, Guglielmi C, Testolin L, Bottio T, and Gerosa G
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- Aged, Cardiac Surgical Procedures economics, Cardiac Surgical Procedures mortality, Cost Savings, Cost-Benefit Analysis, Female, Hospital Costs, Humans, Incidence, Italy epidemiology, Male, Mediastinitis microbiology, Mediastinitis therapy, Middle Aged, Postoperative Complications economics, Postoperative Complications epidemiology, Postoperative Complications mortality, Postoperative Complications pathology, Propensity Score, Reoperation, Retrospective Studies, Risk Factors, Sepsis microbiology, Sepsis therapy, Sternotomy economics, Sternotomy mortality, Surgical Wound Infection microbiology, Surgical Wound Infection therapy, Time Factors, Treatment Outcome, Cardiac Surgical Procedures adverse effects, Negative-Pressure Wound Therapy economics, Postoperative Complications therapy, Sternotomy adverse effects, Surgical Wound Dehiscence
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Objectives: Sternal wound dehiscence (SWD) after cardiac surgery is a rare but serious condition associated with considerable costs and morbidity. We sought to evaluate the results of the introduction of vacuum-assisted closure (VAC) therapy in the management of sternal wound dehiscence, compared with those of previous conventional treatments., Methods: We retrospectively collected 7148 patients who underwent cardiac surgery at our institution between January 2002 and June 2012. A total of 152 (2.1%) patients had a sternal wound dehiscence: 107 were treated with conventional treatments (Group A) and 45 were managed with VAC therapy (Group B). Patients were stratified according to preoperative risk factors and type of sternal wound dehiscence (superficial or deep; infected or not) and compared by means of a propensity-matched analysis. A cost analysis was also performed., Results: Forty-five patients of each group matched for all preoperative risk factors and type of sternal wound dehiscence. SWD-related mortality rate was significantly lower in Group B (11 vs 0%; P = 0.05). Incidence of mediastinitis (P < 0.0001), sepsis (P = 0.04), delayed SWD infection (P = 0.05), other complication (P = 0.05), surgical sternal revision (P = 0.04) and surgical superficial revision (P < 0.0001) were all significantly lower in Group B. Mean patient cost was 31 106€ in Group A and 24 383€ in Group B, thus achieving a mean saving of 6723€ per patient., Conclusions: In our experience, the use of VAC therapy for the management of SWD was considerably effective in decreasing mortality (SWD related), incidence of complications and need for surgical procedures; thus, leading to a significant reduction of costs., (© The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
- Published
- 2014
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173. Prophylactic epicardial left ventricular lead implantation for biventricular pacing during operations.
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Shan L, Buratto E, Conaglen P, Davis P, Yii M, Nixon I, and Newcomb A
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- Aged, Female, Humans, Male, Pericardium, Retrospective Studies, Cardiac Resynchronization Therapy Devices, Cardiac Surgical Procedures, Ventricular Dysfunction, Left surgery
- Abstract
Background: Surgical epicardial left ventricular (LV) lead implantation for biventricular pacing has advantages over the transvenous approach in cardiac surgical patients. We investigated the benefit of concomitant prophylactic LV lead implantation during open heart operations and subsequent lead performance after patients with impaired LV function receive a biventricular device., Methods: Retrospective data of 4,844 patients undergoing cardiac operations through a sternotomy between January 2001 and December 2011 were analyzed. Of these, 380 patients (7.8%) had severe impairment of LV function (contrast left ventriculogram showing grade 4 estimated ejection fraction or echocardiogram showing LV ejection fraction<0.30). LV lead implantation was performed in patients in whom recovery of LV function was unlikely. Lead performance data were collected at follow-up., Results: LV lead implantation occurred in 95 patients (25%), and 29 (30.5%) subsequently received a biventricular device. Of patients with impaired LV function, more patients with prophylactic LV leads underwent biventricular implant than those without LV leads (30.5% vs 1.1%, p<0.0001). The median interval from LV lead implantation to connection to a biventricular device was 30 days (interquartile range, 5.5 to 145 days). At a median follow-up of 437.5 days (interquartile range, 13.8 to 1198 days), the mean pacing threshold (1.25±0.46 vs 1.58±0.66 volts, p=0.069) and impedance (383.81±70.33 vs 448.6±200.1 Ohms, p=0.168) remained stable compared with time of biventricular device connection., Conclusions: A significant proportion of patients with poor LV function undergoing cardiac operations may benefit from concomitant LV lead implantation. Subsequent lead performance appears satisfactory. Epicardial LV lead placement is easily accomplished during open heart operations and should be considered before the operation., (Copyright © 2014 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.)
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- 2014
- Full Text
- View/download PDF
174. Aortic valve hydrodynamics: considerations on the absence of sinuses of Valsalva.
- Author
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Bottio T, Buratto E, Dal Lin C, Lika A, Tarzia V, Rizzoli G, and Gerosa G
- Subjects
- Blood Pressure, Diastole, Heart Rate, Humans, Materials Testing, Models, Cardiovascular, Polyethylene Terephthalates, Prosthesis Design, Prosthesis Failure, Stroke Volume, Systole, Transducers, Pressure, Aortic Valve physiology, Bioprosthesis, Blood Vessel Prosthesis, Heart Valve Prosthesis, Hemodynamics, Sinus of Valsalva physiology
- Abstract
Background and Aim of the Study: The study aim was to compare the hydrodynamics of the Carpentier-Edwards Magna 21 (CEM) and St. Jude Medical Biocor-Epic-Supra 21 (SJME) valves at increasing stroke volume and pulse rate in two different aortic conduits, namely straight and with sinuses of Valsalva present., Methods: Both valve types were tested in the aortic chamber of the Sheffield pulse duplicator, at rates of 70, 80 and 90 beats/min, and stroke volumes of 50 and 60 ml. The systolic and diastolic performances were each recorded. The leaflet coaptation time, ventricle isovolumetric time and maximum instantaneous flow rate were also recorded., Results: Regardless of the aortic conduit, CEM valves showed a significantly lower gradient than SJME valves (p < 0.05), and a significantly larger effective orifice area (EOA) (p < 0.05); the latter parameter was unaffected for both valves, at an increasing pulse rate (p > 0.05). The maximum transvalvular flow velocity was significantly higher in the straight conduit for both valves (p < 0.05). With regards to diastole, the SJME valve showed the lowest regurgitant volume (p < 0.05). The leaflet coaptation time was significantly shorter for the SJME valve than for the CEM valve (p < 0.05), but when tested in a straight conduit it was shortened significantly for both valves (p < 0.05)., Conclusion: An absence of the sinuses of Valsalva may modify the diastolic and systolic behaviors of the tissue valve leaflets by reducing the time required for leaflet coaptation, and increasing the valve closing volume and maximum transvalvular flow velocity. It is speculated that these hydrodynamic changes may increase the working stress on the valve tissue, leading to possible premature structural valve deterioration.
- Published
- 2012
175. Physiological performance of a detergent decellularized heart valve implanted for 15 months in Vietnamese pigs: surgical procedure, follow-up, and explant inspection.
- Author
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Gallo M, Naso F, Poser H, Rossi A, Franci P, Bianco R, Micciolo M, Zanella F, Cucchini U, Aresu L, Buratto E, Busetto R, Spina M, Gandaglia A, and Gerosa G
- Subjects
- Animals, Detergents chemistry, Echocardiography, Female, Follow-Up Studies, Glycosaminoglycans metabolism, Heart Valves ultrastructure, Male, Octoxynol chemistry, Postoperative Care, Sodium Cholate chemistry, Swine, Bioprosthesis, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation, Heart Valves physiology, Heart Valves surgery, Tissue Engineering methods
- Abstract
This study features the longest experimental follow-up for decellularized heart valves implanted in an animal model. Porcine aortic heart valves were decellularized according to a disclosed standardized method in which TRITON X-100 and sodium cholate (TRICOL) are used in succession, followed by a further treatment with the endonuclease Benzonase to completely remove the nucleic acid remnants. Experimental animals (n = 17), represented by Vietnamese pigs (VPs), received a decellularized aortic allograft as a substitute for the replacement of their right ventricular outflow tract. The surgical implantation of the TRICOL-treated aortic valve conduit was successful in 11 VPs, while perioperative or postoperative complications occurred in the remaining six animals. In the sham-operated group (n = 4), the native pulmonary root was excised and immediately reimplanted orthotopically in the same animal. Echocardiography demonstrated a satisfactory hemodynamic performance of the TRICOL-treated valves during follow-up as well as the absence of relevant leaflet alterations concerning thickness and motility or valve insufficiency. At explantation, macroscopic inspection of tissue-engineered heart valve conduits did not evidence calcifications and showed a decreased wall thickness, comparable to that of the reimplanted native pulmonary roots. Noteworthy, extended functional performance, recovery of DNA content, and active extracellular matrix precursor incorporation are apparently compatible with the properties of a living self-supporting substitute., (© 2012, Copyright the Authors. Artificial Organs © 2012, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.)
- Published
- 2012
- Full Text
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176. Cardiomyocytes in vitro adhesion is actively influenced by biomimetic synthetic peptides for cardiac tissue engineering.
- Author
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Gandaglia A, Huerta-Cantillo R, Comisso M, Danesin R, Ghezzo F, Naso F, Gastaldello A, Schittullo E, Buratto E, Spina M, Gerosa G, and Dettin M
- Subjects
- Animals, Cells, Cultured, Immunohistochemistry, Rats, Rats, Inbred F344, Biomimetic Materials pharmacology, Cell Adhesion drug effects, Myocytes, Cardiac cytology, Myocytes, Cardiac drug effects, Peptides pharmacology, Tissue Engineering methods
- Abstract
Scaffolds for tissue engineering must be designed to direct desired events such as cell attachment, growth, and differentiation. The incorporation of extracellular matrix-derived peptides into biomaterials has been proposed to mimic biochemical signals. In this study, three synthetic fragments of fibronectin, vitronectin, and stromal-derived factor-1 were investigated for the first time as potential adhesive sequences for cardiomyocytes (CMs) compared to smooth muscle cells. CMs are responsive to all peptides to differing degrees, demonstrating the existence of diverse adhesion mechanisms. The pretreatment of nontissue culture well surfaces with the (Arginine-Glycine-Aspartic Acid) RGD sequence anticipated the appearance of CMs' contractility compared to the control (fibronectin-coated well) and doubled the length of cell viability. Future prospects are the inclusion of these sequences into biomaterial formulation with the improvement in cell adhesion that could play an important role in cell retention during dynamic cell seeding.
- Published
- 2012
- Full Text
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177. In vitro comparison of different mechanical prostheses suitable for replacement of the systemic atrioventricular valve in children.
- Author
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Bottio T, Dal Lin C, Lika A, Rizzoli G, Tarzia V, Buratto E, and Gerosa G
- Subjects
- Age Factors, Blood Pressure, Cardiac Output, Heart Rate, Heart Valve Prosthesis Implantation adverse effects, Humans, Hydrodynamics, Materials Testing, Mitral Valve pathology, Mitral Valve Insufficiency etiology, Prosthesis Design, Prosthesis Failure, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation instrumentation, Mitral Valve surgery
- Abstract
Objective: The aim of the present study was to compare the hydrodynamics of 4 different mechanical prostheses fitting the atrioventricular annulus in children., Methods: We tested different inverted aortic prostheses with a prosthesis-annulus relationship in the mitral chamber of the Sheffield pulse duplicator (Department of Medical Physics and Clinical Engineering, Royal Hallamshire Hospital, Sheffield, UK), analyzed by comparing the prosthetic housing diameter and the predicted annulus diameter based on body surface area (0.8 and 1 m(2) corresponding to an annulus diameter of 18.8-20.2 mm). The On-X 19 (On-X Life Technologies, Inc, Austin, Tex), SJM Regent 19 (St Jude Medical Inc, St Paul, Minn), Sorin Overline 18 (Sorin Biomedica, Saluggia, Italy), and Medtronic Advantage Supra 19 (Medtronic Inc, Minneapolis, Minn) valves with a housing diameter of 19 to 20 mm were hydrodynamically compared. The tests were carried out at increasing pulse rate of 72, 80, 100, and 120 beats/min for a stroke volume of 20 and 30 mL. Therefore, cardiac output ranged from 1.44 to 3.6 L/min., Results: Regardless of the pulse rate and stroke volume, the Medtronic Advantage Supra valve showed the highest mean diastolic pressure difference at each cardiac output (P < .05). The mean gradients were significantly lower for the Sorin Overline valve regardless of the cardiac output, stroke volume, and pulse rate (P < .05). The effective orifice areas observed followed exactly the same behavior: the lowest for the Medtronic Advantage Supra valve and the highest for the Sorin Overline valve. The Sorin Overline valve showed the highest closure volumes (P < .05), and the On-X prosthesis showed the highest leakage volumes (P < .05). The Sorin Overline valve had the highest total regurgitant volume (P < .05), and the Medtronic Advantage Supra valve had the lowest total regurgitant volume (P < .05). The On-X valve showed the highest total energy loss regardless of the pulse rate at 20 mL of stroke volume, which was comparable to the SJM Regent and Sorin Overline valves at increased stroke volume. The Medtronic Advantage Supra valve showed the lowest total energy loss regardless of cardiac outputs (P < .05)., Conclusions: This hydrodynamic evaluation model allowed us to compare the efficiency of currently available valve prostheses suitable for atrioventricular replacement in children. Among these prostheses, the Sorin Overline valve showed the best diastolic performance. On the other hand, for total energy loss, the Medtronic Advantage Supra valve demonstrated excellent performance., (Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.)
- Published
- 2012
- Full Text
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178. Carpentier-Edwards Magna ease versus Magna valves: a comparison of in-vitro valve hydrodynamic performance.
- Author
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Dal Lin C, Bottio T, Buratto E, Tarzia V, Rizzoli G, Savona V, and Gerosa G
- Subjects
- Bioprosthesis trends, Computer Simulation, Diastole, Echocardiography, Doppler, Color methods, Elastic Modulus, Heart Valve Prosthesis trends, Humans, Hydrodynamics, Mitral Valve diagnostic imaging, Pulsatile Flow, Quality Improvement, Systole, Bioprosthesis standards, Heart Valve Prosthesis standards, Materials Testing instrumentation, Materials Testing methods, Mitral Valve physiopathology, Models, Cardiovascular, Prosthesis Design instrumentation, Prosthesis Design methods
- Abstract
Background and Aim of the Study: Previous studies have shown that the Carpentier-Edwards Magna (CEM) valve is an excellent bioprosthesis in terms of its systolic performance; indeed, it has been described as 'a stented valve with stentless performance'. However, valve performance is not only a matter of gradients; it is also necessary to evaluate the diastolic-phase performance. Previous in-vitro studies have shown that the CEM has an excessive total regurgitant volume. Hence, the study aim was to compare the hydrodynamics of the CEM, with the newly evolved version of this valve, the CEM Ease (CEME)., Methods: The CEM and CEME valves (both 21 mm) were tested in the aortic chamber (23 mm diameter) of the Sheffield pulse duplicator. The tests were carried out at increasing pulse rates (PR; 70-100 beats/min), and at each pulse rate the valve was tested at different stroke volumes (SVs; 45-65 ml). The forward-flow pressure drop, closing leakage volumes and effective orifice area (EOA) were recorded., Results: The CEM and CEME valves showed a comparable systolic-phase performance, there being no significant differences in terms of transvalvular gradient, EOA and stroke work loss, regardless of the PR and SV. In fact, the new CEME exhibited a significantly improved diastolic performance, with the total regurgitant volume being significantly lower, due especially to a reduced leakage volume and, to a lesser extent, a reduced closing volume., Conclusion: The study results indicated that the new CEME valve would maintain the excellent systolic performance of the previous CEM model, but with a significantly improved diastolic performance.
- Published
- 2012
179. The hazard of comparing apples and oranges: the proper indication for the use of recombinant activated clotting factor VII in cardiac surgery.
- Author
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Tarzia V, Bottio T, Buratto E, Spiezia L, Simioni P, and Gerosa G
- Subjects
- Female, Humans, Male, Cardiac Surgical Procedures adverse effects, Critical Care economics, Drug Costs, Factor VIIa administration & dosage, Hemostatic Techniques economics, Hemostatics administration & dosage, Hospital Costs, Postoperative Hemorrhage prevention & control
- Published
- 2011
- Full Text
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180. Freedom solo stentless aortic valve: quantitative and qualitative assessment of thrombocytopenia.
- Author
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Tarzia V, Bottio T, Buratto E, Spiezia L, Simioni P, and Gerosa G
- Subjects
- Female, Humans, Male, Aortic Valve surgery, Bioprosthesis adverse effects, Heart Valve Prosthesis Implantation adverse effects, Thrombocytopenia epidemiology, Thrombocytopenia etiology
- Published
- 2011
- Full Text
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181. The changing hydrodynamic performance of the decellularized intact porcine aortic root: considerations on in-vitro testing.
- Author
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Bottio T, Tarzia V, Dal Lin C, Buratto E, Rizzoli G, Spina M, Gandaglia A, Naso F, and Gerosa G
- Subjects
- Animals, Aortic Valve cytology, Deoxycholic Acid pharmacology, Hemodynamics drug effects, Materials Testing, Octoxynol pharmacology, Prosthesis Design, Prosthesis Failure, Sodium Cholate pharmacology, Sodium Dodecyl Sulfate pharmacology, Swine, Aortic Valve drug effects, Bioprosthesis, Detergents pharmacology, Heart Valve Prosthesis, Tissue Scaffolds
- Abstract
Background and Aim of the Study: The most effective method for decellularization of the intact porcine aortic root remains controversial. Additionally, the hydrodynamic effect that such treatment may have on aortic roots has never been previously investigated. The study aim was to compare the in-vitro hydrodynamic performances of intact porcine aortic roots, both before and after decellularization treatment., Methods: Fifteen fresh porcine aortic roots were tested in the aortic chamber of the Sheffield pulse duplicator (SPD). For study purposes, the roots were first sutured to a silicone aortic root and then hydrodynamically tested. After in-vitro testing, the fresh porcine aortic roots, while still fixed within the silicone root, were decellularized according to various protocols (TRI-COL, TRI-DOC, sodium dodecyl sulfate (SDS) 0.03%, and SDS 0.1%). After decellularization, the valve roots were re-tested, adopting identical testing conditions. Forward flow pressure drop, closing leakage volumes, effective orifice area (EOA), and stroke work loss were each monitored. Three roots, used as a control group, were tested in identical fashion before and after storage (without decellularization) for comparative purposes., Results: The TRI-COL- and TRI-DOC-treated porcine aortic roots showed significantly lower transvalvular gradients, lower stroke work loss, lower valve resistance, and higher EOA than fresh intact porcine roots. In contrast, SDS 0.1%-treated porcine aortic roots showed opposing results, with the transvalvular gradients, stroke work loss and valve resistance each higher, and the EOA lower, than pre-treatment values. SDS 0.03% treatment had no significant effect on the hydrodynamic performance. After decellularization in all treatment groups, the diastolic parameters, total regurgitant volume and valve closing volume were each non-significantly increased. The aortic roots used as a control group showed similar results before and after storage., Conclusion: Based on these results using the SPD, all treatments except for SDS 0.03% modified the systolic and diastolic functions of intact porcine aortic roots.
- Published
- 2010
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