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153. Proceedings of the 15th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc.

Author

Acun, Ceyda, Akugizibwe, Collins, Aly, Hany, Avian, Alexa AschAlexander, Aycan, Nur, Baik-Schneditz, Nariae, Bailey, Sean, Balog, Vera, Barra, Magdolna, Bartolini, Ellen, Basaranoglu, Murat, Bauerstätter, Priska, Bazan, Angel, Berger, Angelika, Boardman, James P, Boylan, Geraldine, Bruckner, Marlies, Bua, Jenny, Buchmayer, Julia, and Caprio, Martha

Subjects
DEMOGRAPHIC characteristics, CEREBRAL anoxia-ischemia, SCHOOL children, APGAR score, PERSISTENT fetal circulation syndrome, TRANSCRANIAL Doppler ultrasonography, MACHINE learning, PEDIATRICS
Abstract

This document is a compilation of abstracts from the 15th International Newborn Brain Conference, focusing on various forms of brain monitoring in preterm neonates. The abstracts cover topics such as predicting posthemorrhagic ventricular dilatation in neonates with intraventricular hemorrhage, the association between blood lactate normalization and outcomes in neonates with hypoxic-ischemic encephalopathy, the implementation of cerebral near-infrared spectroscopy in a neonatal intensive care unit, cry analysis as a potential biomarker in newborn neurological assessment, and the impact of neonatal hypoxia on thyroid hormones. Another study investigates the use of near-infrared spectroscopy in assessing splanchnic oxygenation in preterm infants receiving minimal enteral nutrition. The document also includes the names and affiliations of the authors. [Extracted from the article]

Published
2024
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154. Surgical and radiosurgical treatment of hypothalamic hamartoma: The Italian experience between 2011 and 2021.

Author

Rizzi, Michele, Consales, Alessandro, Tramacere, Irene, De Benedictis, Alessandro, Bua, Antonella, Specchio, Nicola, De Palma, Luca, Cognolato, Erica, Nobili, Lino, Tortora, Domenico, Barba, Carmen, Pommella, Marianna, Giordano, Flavio, Pastori, Chiara, Marchetti, Marcello, Garbelli, Rita, Zucchelli, Mino, Martinoni, Matteo, Ferri, Lorenzo, and Martucci, Matia

Subjects
EPILEPSY surgery, STEREOTACTIC radiosurgery, PEOPLE with epilepsy, UNIVARIATE analysis, SEIZURES (Medicine)
Abstract

Objective: To investigate the Italian experience on the surgical and radiosurgical treatment of drug‐resistant epilepsy due to hypothalamic hamartoma (HH) in the period 2011–2021 in six Italian epilepsy surgery centers, and to compare safety and efficacy profiles of the different techniques. Methods: We collected pseudo‐anonymized patient's data with at least 12 months of follow‐up. Surgical outcome was defined according to Engel classification of seizure outcome. Univariate analysis was performed to assess the risk of post‐operative seizures, categorized in dichotomous variable as favorable and unfavorable; explanatory variables were considered. Mann–Whitney or Chi‐squared test were used to assess the presence of an association between variables (p < 0.05). Results: Full presurgical and postoperative data about 42 patients from 6 epilepsy surgery centers were gathered. Engel class I was reached in the 65.8% and 66.6% of patients with gelastic and non‐gelastic seizures, respectively. Other than daily non‐gelastic seizures were associated with seizure freedom (p = 0.01), and the radiological type presented a trend toward significance (p = 0.12). Significance: Endoscopic disconnection and laser interstitial thermal therapy are effective in the treatment of HH‐related epilepsy, with a tolerable safety profile. Both gelastic and non‐gelastic seizures can be treated, also in patients with a long history of seizures. Plain Language Summary: This study collected data about 42 patients with HH‐related epilepsies. Endoscopic disconnection and laser therapy are both effective and safe in the treatment of hypothalamic hamartoma‐related epilepsies. [ABSTRACT FROM AUTHOR]

Published
2024
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155. Democracy, Participation, and Capitalist Crisis: An Interview with Nancy Fraser.

Author

Fraser, Nancy, Bua, Adrian, and Vlahos, Nick

Subjects
DEMOCRACY, CAPITALISM, POLITICAL participation, PUBLIC sphere
Abstract

This conversation with Nancy Fraser explores her work on the crises of capitalism, democracy, and participation. Fraser has argued that much scholarship in political science and democratic theory on these issues is hampered by "politicism"—an inclination to view the political in separation from other social spheres, which fails to appreciate the structural nature of contemporary crises. Fraser argues that the political arena is important because it is here that collective regulatory powers are exercised, however it needs to be situated within a broader understanding of the social totality to understand how it is affected by crisis dynamics in other spheres and how it might contribute to attenuating, or resolving, these. Our conversation begins by exploring these arguments in relation to Fraser's recent work on the critique of capitalism, and then traces how this relates to her work on the public sphere, participatory parity, and utopian thought. [ABSTRACT FROM AUTHOR]

Published
2024
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156. How to Democratize the Economy: Combining Democratic Theory and Critical Political Economy.

Author

Vlahos, Nick, Bua, Adrian, and Gagnon, Jean-Paul

Subjects
ECONOMICS, CAPITALISM, SOCIAL reproduction, EMPLOYEE ownership, HISTORICAL analysis
Abstract

This issue of Democratic Theory aims to contribute to critical social science by bridging the gap between democratic theory and critical political economy (CPE). Despite a common grounding in a normative commitment to emancipation, these fields have lately spoken past each other. Democratic theory is relatively voluntarist, focusing on the realization of normative principles through institutional design. However, it has often overlooked capitalism's influence on democracy, and accepted the artificial separation of the political and economic realms in ways that constrain the possibilities for democratic expansion. CPE, on the other hand, has developed realist and historical analyses of capitalist constraint and dynamism. It can offer a structural compass for democratic theories' interventionist energies, while also being moved beyond pure critique by them. The central theme of this issue, "democratizing the economy," shifts the focus toward a deeper exploration of the potential for democratic designs to transform economic structures. [ABSTRACT FROM AUTHOR]

Published
2024
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157. Zeta-carbonic anhydrases show CS2 hydrolase activity: A new metabolic carbon acquisition pathway in diatoms?

Author

Vincenzo Alterio, Emma Langella, Martina Buonanno, Davide Esposito, Alessio Nocentini, Emanuela Berrino, Silvia Bua, Maurizio Polentarutti, Claudiu T. Supuran, Simona Maria Monti, and Giuseppina De Simone

Subjects
Cambialistic enzyme, Carbonic Anhydrase, CO2, CS2, Molecular dynamics, Biotechnology, TP248.13-248.65
Abstract

CDCA1 is a very peculiar member of the Carbonic Anhydrase (CA) family. It has been the first enzyme to show an efficient utilization of Cd(II) ions in Nature and a unique adaptation capability to live on the surface ocean. Indeed, in this environment, which is extremely depleted in essential metal ions, CDCA1 can utilize Zn(II) or Cd(II) as catalytic metal to support the metabolic needs of fast growing diatoms. In this paper we demonstrate a further catalytic versatility of this enzyme by using a combination of X-ray crystallography, molecular dynamics simulations and enzymatic experiments. First we identified the CO2 binding site and the way in which this substrate travels from the environment to the enzyme active site. Then, starting from the observation of a structural similarity with the substrate entry route of CS2 hydrolase from Acidanius A1-3, we hypothesized and demonstrated that also CS2 is a substrate for CDCA1. This finding is new and unexpected since until now only few CS2 hydrolases have been characterized, and none of them is reported to have any CO2 hydratase action. The physiological implications of this supplementary catalytic activity still remain to be unveiled. We suggest here that it could represent another ability of diatoms expressing CDCA1 to adapt to the external environment. Indeed, the ability of this enzyme to convert CS2 could represent an alternative source of carbon acquisition for diatoms, in addition to CO2.

Published
2021
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158. Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII. The out of the active site pocket for the design of selective inhibitors?

Author

Leonardo E. Riafrecha, Macarena S. Le Pors, Martín J. Lavecchia, Silvia Bua, Claudiu T. Supuran, and Pedro A. Colinas

Subjects
vanillin, carbonic anhydrase, enzyme inhibitors, molecular docking, enones, Therapeutics. Pharmacology, RM1-950
Abstract

New C-glycosides and α,β-unsaturated ketones incorporating the 4-hydroxy-3-methoxyphenyl (vanillin) moiety as inhibitors of carbonic anhydrase (CA, EC 4.2.1.1) isoforms have been investigated. The inhibition profile of these compounds is presented against four human CA (hCA) isozymes, comprising hCAs I and II (cytosolic, ubiquitous enzymes) and hCAs IX and XII (tumour associated isozymes). Docking analysis of the inhibitors within the active sites of these enzymes has been performed and is discussed, showing that the observed selectivity could be explained in terms of an alternative pocket out of the CA active site where some of these compounds may bind. Several derivatives were identified as selective inhibitors of the tumour-associated hCA IX and XII. Their discovery might be a step in the strategy for finding an effective non-sulfonamide CA inhibitor useful in therapy/diagnosis of hypoxic tumours or other pathologies in which CA isoforms are involved.

Published
2021
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159. L’importanza della comunicazione aumentativa alternativa e il suo impatto nella qualità di vita dei pazienti affetti da SLA.

Author

Alberto Bua, Maria Rosa Paterniti, Antonino Petronaci, Emmanuela Accorso, Simona Orobello, and Gemma Levantino

Subjects
Logopedia, CAA, SLA., Medicine, Therapeutics. Pharmacology, RM1-950
Abstract

INTRODUZIONE Questo lavoro di ricerca prende in esame pazienti affetti da Sclerosi Laterale Amiotrofica (SLA), con l’obiettivo di verificare come l’utilizzo di ausili di comunicazione aumentativa alternativa (CAA) consentono alla persona di interagire con l’ambiente e con i vari partner comunicativi, migliorando la loro qualità di vita. MATERIALI E METODI Sono stati presi in esame n.11 pazienti con diagnosi di SLA, ai quali è stato somministrato il test AAC Device Trial Checklist & Rubric, ripetuto a distanza di sei mesi. Il test consente di valutare la capacità da parte del paziente di utilizzare il sistema di comunicazione aumentativa alternativa di cui dispone, in uno o più ambienti comunicativi e con uno o più partner comunicativi. RISULTATI I risultati della ricerca, in linea con le evidenze scientifiche di settore, hanno rivelato che i pazienti presi in esame hanno tratto beneficio dall’utilizzo di ausili di comunicazione aumentativa alternativa. Dalle valutazioni effettuate si riscontrano risultati migliori (100% dei casi) nell’utilizzo del sistema di CAA in due ambienti e con almeno 2 partner comunicativi. L’82% dei casi mostra dei miglioramenti nell’utilizzo della CAA per la richiesta di oggetti e azioni. Il 72,7% dei casi mostra miglioramenti nell’utilizzo della CAA per gli scopi comunicativi legati all’espressione di emozioni e/o per richiamare l’attenzione del partner comunicativo. DISCUSSIONE La ricerca sottolinea attraverso i risultati quanto sia importante l’utilizzo dei sistemi di CAA in persone con disabilità del linguaggio espressivo e di quanto risulti fondamentale il ruolo del logopedista nel progetto di CAA. Il logopedista, infatti, estende la propria azione professionale alla valutazione delle funzioni neurolinguistiche potendo così contribuire grandemente alla conoscenza delle caratteristiche individuali della disabilità della persona. CONCLUSIONI Una corretta presa in carico multidisciplinare, che includa una valutazione delle competenze comunicative del soggetto e la scelta dell’ausilio di CAA più adeguato, nelle condizioni in cui l’eloquio della persona risulti essere intellegibile, migliora l’interazione e il coinvolgimento della persona con i diversi partner comunicativi e l’ambiente esterno, migliorando di conseguenza la qualità di vita della persona

Published
2022

164. Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia

Author

Rispoli, Vincenzo, Malara, Alba, Spadea, Fausto, Di Cello, Serena, Ceravolo, Francesco, Fabiano, Francesco, Chiaradia, Giuseppe, Gabriele, Amedeo, Lenino, Peluso, Andrea, Taristano, Settembrini, Vincenzo, Capomolla, Domenico, Citrino, Antonella, Scriva, Antonietta, Bruno, Irene, Secchi, Roberto, De Martino, Eugenio, Muccinelli, Roberto, Lupi, Gerardo, Paonessa, Patrizio, Fabbri, Andrea, Passuti, Maria Teresa, Castellari, Sofia, Po, Andrea, Gaggioli, Guido, Varesi, Massimo, Moneti, Paolo, Capurso, Sebastiano, Latini, Vincenzo, Ghidotti, Stefano, Riccardelli, Francesco, Macchi, Maurizio, Rigo, Rosaria, Claudio, Pascale, Angelo, Bosio, Flavio, Cerrato, Benedetta, Bardelli, Boffelli, Stefano, Cassinadri, Angela, Franzoni, Simone, Spazzini, Elena, Andretto, Daniela, Tonini, Gabriele, Andreani, Laura, Coralli, Mirco, Balotta, Antonio, Cancelliere, Roberto, Ballardini, Giorgio, Simoncelli, Margherita, Mancini, Annarita, Strazzacapa, Mara, Fabio, Stefano, De Filippi, Francesco, Giudice, Chiara, Dentizzi, Cosimo, Azzini, Margherita, Cazzadori, Marco, Mastroeni, Valeria, Bertassello, Paolo, Claudia Benati, Helena Santana, Nesta, Elisa, Tobaldini, Chiara, Guerini, Fabio, Elena, Tambara, Mombelloni, Paolo, Fontanini, Fulvio, Gabriella, Lassa, Pizzorni, Crosio, Oliverio, Martina, Del Grosso, Luciano Luca, Giavedoni, Cristina, Bidoli, Giuliano, Mazzei, Bruno, Corsonello, Andrea, Fusco, Sergio, Vena, Silvio, De Vuono, Tommaso, Maiuri, Giorgio, Luca, Fimognari Filippo, Andrea, Arone, Giovanni, Sgrò, Rossella, Nicolazzo, Castegnaro, Eugenio, De Rosa, Salvatore, Sechi, Rossella Bazzano, Benvenuti, Enrico, Del Lungo, Ilaria, Giardini, Sante, Giulietti, Chiara, Mauro, Di Bari, Eleonora, Barghini, Martina, Paoli, Irene, Fiordelli, Riccardo, Barucci, Federica, Sgrilli, Ilaria, Del Lungo, Bertoletti, Erik, D'Amico, Ferdinando, Caronzolo, Francesco, Grippa, Alessandro, Lombardo, Giuseppina, Pipicella, Tiziana, Antonino, Saitta, Francesco, Corica, Valeria, Prestipino Giarritta, Daniela, Larosa, Domenico, Cucinotta, Giorgio, Basile, March, Albert, Nitti, Maria Teresa, Felici, Alessandro, Pavan, Silvia, Piazzani, Fabrizio, Lunelli, Alessandra, Dimori, Sergio, Margotta, Alessandro, Soglia, Tiziano, Postacchini, Demetrio, Brunelli, Roberto, Santini, Silvia, Francavilla, Monia, Macchiati, Ilenia, Sorvillo, Francesca, Giuli, Cinzia, Mecocci, Patrizia, Longo, Annalisa, Perticone, Francesco, Addesi, Desireè, Rosa, Paola Cerra, Bencardino, Giuseppe, Falbo, Tania, Grillo, Nadia, Marco, Filice, Mirella, Flippo, Fantò, Fausto, Isaia, Gianluca, Pezzilli, Stella, Bergamo, Daniele, Furno, Elisabetta, Rrodhe, Sokol, Lucarini, Simonetta, Dijk, Babette, Dall'Acqua, Francesca, Cappelletto, Francesco, Calvani, Donatella, Becheri, Dimitri, Giuseppe, Mottino, Costanza, Mitidieri, Vito, Antonio, Francesca, Bartalucci, Magherini, Lorenza, Novella, Malin, Franca, Boni, Lucia Gambardella, Paoli Martina, Valente, Carlo, Ilaria, Bracali, Alice, Foschini, Bo, Mario, Porrino, Paola, Ceci, Giacomo, Giuliana, Bottignole, Michela, Tibaldi, Eleonora, Coppo, Ettore, Evaristo, Camellini, Cinzia, Servello, Adriana, Grassi, Alessandro, Rozzini, Renzo, Tironi, Sara, Grassi, Maria Grazia, Troisi, Elio, Carlo, Caltagirone, Simona Gabriella, Di Santo, Flaminia, Franchini, Federica, Ratto, Beatrice, Pavoni, Sofia, Toniolo, Gabutto, Anna, Quazzo, Loredana, Rosatello, Annalisa, Suraci, Domenico, Tagliabue, Benedetta, Perrone, Chiara, Ferrara, Lucia, Castagna, Alberto, Tremolada, Maria Luisa, Giuseppe, Castoldi, Stefano, Barbero, Davide, Oltramonti, Piano, Simonetta, Serviddio, Gaetano, Lo Buglio, Aurelio, Gurrera, Tiziana, Merlo, Valeria, Rovai, Carla, Cotroneo, Antonino Maria, Carlucci, Rosaria, Abbaldo, Anna, Monzani, Fabio, Qasem, Ahmad Amedeo, Bini, Giacomo, Tafuto, Silvia, Galli, Giovanni, Bruni, Amalia Cecilia, Mancuso, Giovanna, Mancuso, Gerardo, Calipari, Daniela, Giuseppe Massimiliano, De Luca, Bernardini, Bruno, Corsini, Carla, Michele, Ciccarelli, Sara, Dal Farra, Cagnin, Annachiara, Fragiacomo, Federica, Pompanin, Sara, Piero, Amodio, Marco, Cagnin, Zurlo, Amedeo, Guerra, Gianluca, Pala, Marco, Menozzi, Luca, Gatti, Chiara Delli, Magon, Stefania, Roberto, Manfredini, Alfredo, De Giorgi, Fabio, Fabbian, Ruana, Tiseo, Elisa, Misurati, Benedetta, Boari, Christian, Molino, Marco, Pala, Massimo, Gallerani, Di Francesco, Vincenzo, Faccioli, Silvia, Pellizzari, Luca, Giorgia, Fontana, Barbagallo, Giuseppe, Lunardelli, Maria Lia, Martini, Emilio, Ferrari, Eleonora, Macchiarulo, Maria, Corneli, Maria, Bacci, Monica, Battaglia, Giuseppe, Anastasio, Luigi, Lo Storto, Mario Sostene, Seresin, Chiara, Simonato, Matteo, Loreggian, Michele, Cestonaro, Fausta, Durando, Mario, Latella, Raffaele, Mazzoleni, Marta, Russo, Giuseppe, Ponte, Martino, Valchera, Alessandro, Salustri, Giuseppe, Petritola, Donatella, Costa, Alfredo, Sinforiani, Elena, Cotta, Matteo Ramusino, Pizio, Renato Nicola, Cester, Alberto, Formilan, Marino, Pietro, Bonometto, Carbone, Pasqualina, Cazzaniga, Ilaria, Appollonio, Ildebrando, Cereda, Diletta, Stabile, Andrea, Xhani, Rubjona, Acampora, Roberto, Tremolizzo, Lucio, Federico, Pieruzzi, Antonio, Ciaccio, Valerio, Pontecorvi, Cesare, Burti, Zhirajr, Mokini, Giovanni, Vitale, Maria, Amigoni, Mariaelena, Sparacino, Bottacchi, Edo, Bucciantini, Elisabetta, Di Giovanni, Marco, Franchi, Fabrizio, Lucchetti, Lucio, Mariani, Claudio, Grande, Giulia, Rapazzini, Piero, Marco, Mauri, Romanelli, Giuseppe, Marengoni, Alessandra, Franco, Nicosia, Alessio, Margola, Stefano, Bonardelli, Nicola, Latronico, Laura, Porcella, Nazario, Portolani, Carlo, Concoreggi, Chiara, Grassini, Soccorso, Pronto, Andrea, Salvi, Luca, Bianchetti, Francesca, Spagnoli, Roberto, Apuzzo, Marco, Fontanella, Anna, Ceraso, Francesco, Castelli, Fugazza, Luciano, Guerrini, Chiara, De Paduanis, Giovanna, Iallonardo, Lucia, Palumbo, Pasquale, Zuliani, Giovanni, Ortolani, Beatrice, Capatti, Eleonora, Soavi, Cecilia, Bianchi, Lara, Francesconi, Daniela, Miselli, Agata, Gloria, Brombo, Tommaso, Romagnoli, Chiara, Pazzaglini, Agata, Miselli Maria, Marco, Dall'Agata, Luca, Menozzi, Gianluca, Guerra, Suardi, Teresa, Mazzone, Andrea, Zaccarini, Cinzia, Manuela, Riva, Mirra, Gianluca, Muti, Ettore, Bottura, Renato, Gianpaolo, Moretti, Secreto, Piero, Bisio, Erika, Cecchettani, Marco, Naldi, Tamara, Pallavicino, Alessandra, Pugliese, Michela, Iozzo, Rosaria Cosima, Grassi, Guido, Michele, Bombelli, Raffaella, Dell'Oro, Fosca, Quarti Trevano, Giorgio, Giussani Carlo, Giovanni, Paternò, Ernesto, Contro, Mannironi, Antonio, Giorli, Elisa, Oberti, Sara, Fierro, Brigida, Piccoli, Tommaso, Giacalone, Fabio, Mandas, Antonella, Serchisu, Luca, Costaggiu, Diego, Pinna, Elisa, Orrù, Francesca, Mannai, Martina, Cordioli, Zeno, Pelizzari, Luca, Turcato, Emanuela, Arduini, Pietro, Cacace, Carlo, Chiloiro, Roberta, Cimino, Rosella, Ruberto, Carmen, Giovanni, Ruotolo, Pietro, Gareri, Laura, Greco, Alberto, Castagna, Carmen, Ruberto, Santo, Pierluigi Dal, Andriolli, Antonino, Burattin, Giuseppe, Rossi, Laura, Andreolli Antonino, Cervati Giovanna, Giuseppe, Catalano, Tezza, Fabiana, Maddalena, Pizzardini, Laura, Stievano, Crippa, Patrizia, Aloisio, Paola, Di Monda, Tiziana, Malighetti, Alessandro, Galbassini, Gloria, Salutis, Domus, Ivaldi, Claudio, Russo, Anna Maria, Bennati, Ettore, Pino, Elisabetta, Zavarise, Gianmaria, Pesci, Alberto, Suigo, Giulia, Faverio, Paola, Andrea, Gori, Sabrina, Perego, Zanasi, Massimo, Moniello, Giovanni, Rostagno, Carlo, Cartei, Alessandro, Polidori, Gianluca, Ungar, Andrea, Melis, Maria Ramona, Martellini, Eleonora, Enrico, Mossello, Monica, Torrini, Antonella, Giordano, Giovanna, Leone, Migliorini, Marta, Caramelli, Francesca, Battiston, Bruno, Berardino, Maurizio, Cavallo, Simona, Alessandro, Massè, Anna, Santoro, Lombardi, Bruna, D'Ippolito, Pierpaolo, Furini, Angela, Villani, Daniele, Clara, Raimondi, Guarneri, Massimo, Paolucci, Stefano, Bassi, Andrea, Coiro, Paola, De Angelis, Domenico, Morone, Giovanni, Venturiero, Vincenzo, Palleschi, Lorenzo, Raganato, Paolo, Di Niro, Giuseppina, Rosa, Casini Anna, Loredana, Bove, Imoscopi, Alessandra, Isaia, Giancarlo, Tibaldi, V., Bottignole G, G., Calvi, E., Clementi, C., Zanocchi, M., Agosta, L., Nortarelli, Antonella, Provenzano, Giuseppe, Mari, Daniela, Romano, Federica Ylenia, Rosini, Francesca, Mansi, Marta, Rossi, Silvia, Geriatria, Alex Riccardelli, Inzaghi, Lorenzo, Bonini, Giulia, Rossi, Paolo, Potena, Alfredo, Lichii, Mihaela, Candiani, Tiziana, Grimaldi, William, Bertani, Emiliano, Alessandra, Porta, Calogero, Pietro, Pinto, Daniela, Bernardi, Roberto, Nicolino, Francesco, Galetti, Caterina, Gianstefani, Alice, Giulia, Corvalli, Lorenzo, Mulazzani, Odetti, Patrizio, Monacelli, Fiammetta, Prefumo, Matteo, Fiammetta, Monacelli, Canepa, Marta, Minaglia, Cecilia, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Prestano, Raffaele, Dalise, Anna Maria, Barra, Davide, Bosco, Livio Dal, Asprinio, Vincenzo, Dallape, Luciana, Perina, Elisa, Incalzi, Raffaele Antonelli, Bartoli, Isaura Rossi, Pluderi, Alice, Maina, Antonella, Pecoraro, Elisabetta, Sciarra, Michela, Prudente, Angela, Paola, Maina, Francesca, Mete, Manuel, Ventura, Luisella, Cesari, Maria, Pernigotti Luigi, Tina, Santangelo, Benini, Lucia, Levato, Francesco, Mhiuta, Victor, Alius, Florin, Davidoaia, Diana, Giardini, Vittorio, Garancini, Mattia, Bellamoli, Claudio, Terranova, Luciano, Bozzini, Claudia, Tosoni, Paolo, Provoli, Emma, Cascone, Luisa, Dioli, Andrea, Ferrarin, Gianfranco, Bucci, Adelmo, Bua, Guido, Fenu, Sara, Bianchi, Giovanna, Casella, Silvia, Romano, Valentina, Maurizio, Poli, Mascherona, Ilenia, Belotti, Gloria, Cavaliere, Sabina, Cuni, Estella, Merciuc, Nina, Oberti, Rosella, Veneziani, Silvia, Capoferri, Emanuela, De Bernardi, Elisabetta, Colombo, Katia, Bravi, Marco, Nicoletta, Negrinotti, D'Arcangelo, Paolo, Montenegro, Nicola, Montanari, Roberto, Lamanna, Pierpaolo, Gasperini, Beatrice, Isabella, Montesi, Stefania, Diotallevi, Gaia, Altobelli, Filippo, Calcinaro, Palamà, Chiara, Di Emidio, Chiara, Scarpini, Elio, Arighi, Andrea, Fumagalli, Giorgio, Basilico, Paola, De Amicis Margherita, Migone, Marta, Mancarella, Diletta, Maira, Granata, Antonino, Ranalli, Claudia, Cammilli, Alessandra, Cavallini, Maria Chiara, Tricca, Manola, Natella, Daniela, Gabbani, Luciano, Tesi, Francesca, Martella, Letizia, Imbrici, Rosalba, Guerrini, Gianbattista, Scotuzzi, Anna Maria, Sozzi, Ferdinando, Valenti, Luigi, Chiarello, Antonino, Monia, Monella, Pilotto, Alberto, Prete, Camilla, Senesi, Barbara, Meta, Anna Cristina, Pendenza, Enrico, Pasqualetti, Giuseppe, Polini, Antonio, Tognini, Sara, Ballino, Elena, Cherubini, Antonio, Dell'Aquila, Giuseppina, Gasparrini, Pina Maria, Marotti, Elisabetta, Migale, Monica, Scrimieri, Antonia, Falsetti, Lorenzo, Salvi, Aldo, Toigo, Gabriele, Ceschia, Giuliano, Rosso, Alessia, Tongiorgi, Chiara, Scarpa, Cristina, Maurizio, Pacchioni, De Dominicis, Luigino, Pucci, Eugenio, Renzi, Sara, Cartechini, Elisabetta, Tomassini, Pia Francesca, Del Gobbo, Maurizio, Ugenti, Francesca, Romeo, Pasquale, Nardelli, Anna, Lauretani, Fulvio, Visioli, Sandra, Montanari, Ilaria, Ermini, Francesca, Giordano, Antonio, Pigato, Giorgio, Simeone, Emilio, Barbujani, Mario, Giampieri, Marina, Amoruso, Raffaele, Piccinini, Maristella, Ferrari, Camilla, Gambetti, Claudio, Sfrappini, Mario, Semeraro, Letizia, Striuli, Rinaldo, Mariani, Claudia, Pelliccioni, Giuseppe, Marinelli, Donatella, Fabi, Katia, Rossi, Tommaso, Pesallaccia, Martina, Sabbatini, Debora, Gobbi, Beatrice, Cerqua, Raffaella, Tagliani, Giancarla, Schlauser, Elena, Caser, Luciano, Caramello, Elisa, Sandigliano, Franca, Rosso, Giorgio, Ferrari, Alberto, Bendini, Chiara, Luisa, Davoli Maria, Casella, Monica, Prampolini, Raffaella, Scevola, Moreno, Vitale, Enrico, Roberto, Brugiolo, Carlo, Fagherazzi, Sergio, Fusco, Alberto, Scarpa, Daniela, Zara, Giulia, Bertozzo, Serena, Granziera, Michele, Barazzuol, Maugeri, Domenico, Sorace, Rosaria, Anzaldi, Massimiliano, De Gesu, Roberto, Morrone, Giuseppe, Davolio, Federica, Fabbo, Andrea, Palmieri, Marina, Zoli, Marco, Forti, Paola, Pirazzoli, Luca, Fabbri, Elisa, Terenzi, Laura, Bergolari, Federica, Wenter, Christian, Ruffini, Ingrid, Insam, Miriam, Abraham, Elisabeth, Kirchlechner, Christine, Cucinotta, Domenico, Antonino, Lasco, Basile, Giorgio, Grazia, Arena Maria, Parise, Pasquale, Boccali, Andrea, Amici, Serena, Gambacorta, Maurizia, Lasagni, Anna, Lovati, Roberto, Giovinazzo, Francesca, Kimak, Elzbieta, Zappa, Paolo, Medici, Francesco, Lo Castro, Marika, Mauro, Flavia, De Luca, Alessandro, Sancesario, Giuseppe, Martorana, Alessandro, Scaricamazza, Beatrice, Toniolo, Sofia, Di Lorenzo, Francesco, Liguori, Claudio, Lasco, Antonino, Vita, Natale, Giomi, Mirna, Forte, Floriana, Padovani, Alessandro, Rozzini, Luca, Ceraso, Anna, Salvatore, Caratozzolo, Cottino, Maria, Vitali, Silvia, Marelli, Eleonora, Tripi, Gabriele, Miceli, Salvatore, Urso, Giovanni, Grioni, Giuseppe, Vezzadini, Giuliana, Misaggi, Giulia, Forlani, Chiara, Avanzi, Stefano, Serena, Saulle, Claudia, Casarini, Marilena, Viggiano, Alberto, Luisa, Diego, Ghianda, Alessandro, Giordano, Iemolo, Francesco, Giordano, Antonello, Sanzaro, Enzo, D'Asta, Gabriele, Proietto, Maria, Carnemolla, Anna, Razza, Grazia, Spadaro, Daniela, Bertolotti, Marco, Mussi, Chiara, Neviani, Francesca, Roberto, Chiesa, Valentina, Guerzoni, Linda, Morselli, Francesca, Venturelli, Tarozzi, Adriano, Balestri, Francesca, Mannarino, Giulio, Bigolari, Michela, Natale, Alessia, Grassi, Simona, Bottaro, Cinzia, Stefanelli, Sara, Bovone, Ugo, Tortorolo, Umberto, Quadri, Roberto, Leone, Giuseppe, Ponzetto, Maria, Frasson, Paola, Annoni, Giorgio, Bellelli, Giuseppe, Bruni, Adriana, Confalonieri, Roberto, Corsi, Maurizio, Moretti, Daniela, Teruzzi, Fabiola, Umidi, Simona, Mazzola, Paolo, Perego, Sabrina, Persico, Ilaria, Olivieri, Giulia, Bonfanti, Alessandra, Hajnalka, Szabò, Galeazzi, Marianna, Massariello, Francesca, Anzuini, Alessandra, Caffarra, Paolo, Barocco, Federica, Spallazzi, Marco, Paolo, Ceda Gian, Simonetta, Morganti, Andrea, Artoni, Chioatto, Paolo, Bortolamei, Sandra, Soattin, Lucia, Ruotolo, Giovanni, Beneamino, Borelli, Giuseppe, Barilaro, Bertazzoli, Marco, Rota, Elisabetta, Adobati, Annamaria, Scarpa, Alberto, Granziera, Serena, Zuccher, Paola, Fabbro, Angela Dal, Zara, Daniela, Lo Nigro, Ambra, Franchetti, Lorena, Toniolo, Marika, Marcuzzo, Cinzia, Rollone, Marco, Guerriero, Fabio, Sgarlata, Carmelo, Massè, Alessandro, Zatti, Giovanni, Piatti, Massimiliano, Graci, Jole, Benati, Giuseppe, Boschi, Federica, Biondi, Mario, Fiumi, Nicoletta, Erika, Tamburini, Locatelli, Sergio Mario, Mauri, Sabrina, Beretta, Mauro, Margheritis, Laura, Desideri, Giovanbattista, Liberatore, Ester, Carucci, Anna Cecilia, Bonino, Paolo, Caput, Margherita, Antonietti, Maria Paola, Polistena, Giuseppe, De la Pierre, Franz, Mari, Marcello, Massignani, Paola, Tombesi, Fabio, Selvaggio, Fabio, Verbo, Brunella, Bodoni, Paolo, Marchionni, Niccolò, Mossello, Enrico, Sabatini, Tony, Mussio, Eleonora, Magni, Eugenio, Bianchetti, Angelo, Crucitti, Andrea, Titoldini, Giulia, Cossu, Beatrice, Fascendini, Sara, Licini, Cristina, Tomasoni, Angela, Calderazzo, Massimo, Daniela, Tropiano, Valentina, Laganà, Melotti, Rita Maria, Lilli, Albina, Buda, Simona, Adversi, Marco, Noro, Gabriele, Turco, Renato, Ubezio, M Chiara, Mantovani, Anna Roberta, Viola, Maria Cristina, Serrati, Carlo, Pretta, Stefano, Infante, Maria, Gentile, Simona, Morandi, Alessandro, D'Ambrosio, Viviana, Mazzanti, Paolo, Brambilla, Cristina, Sportelli, Silvia, Platto, Caterina, Faraci, Bianca, Quattrocchi, Daniela, Pernigotti, Luigi Maria, Pisu, Cristina, Sicuro, Francesca, Zagnoni, Piergiuseppe, Ghiglia, Stefania, Mosca, Massimiliano, Corazzin, Ileana, Deola, Mariangela, Biagini, Carlo Adriano, Bencini, Francesca, Cantini, Claudia, Tonon, Elisabetta, Pierinelli, Silvia, Onofrj, Marco, Thomas, Astrid, Filomena, Borbone, Bonanni, Laura, Gabriella, Cacchiò, Comi, Giancarlo, Magnani, Giuseppe, Santangelo, Roberto, Mazzeo, Salvatore, Giuseppe, Magnani, Francesca, Caso, Giordano, Cecchetti, Roberto, Sant'Angelo, Barbieri, Cristina, Giroldi, Liviana, Bandini, Fabio, Masina, Marco, Malservisi, Simona, Cicognani, Annalena, Ricca, Laura, Piccininni, Maristella, Tassinari, Tiziana, Brogi, Davide, Sugo, Annalisa, Alessandra, Filippi, Sonia, Manfredi, Valerio, Vanni, Andrea, Usai Carlo, Enrico, Colombo, Vera, Renna Francesca, Assunta, Sauchella, Gianmaria, Zavarise, Mauro, Prete, Pietro, Bisagni, Roberto, Masini, Salvatore, Carrabetta, Barone, Antonella, Razzano, Monica, Giuseppe, Imperoli, Angela, Bini, Francesco, Serra, Valeria, D'Agostino, Federico, Gianolla, Lucia, Pietrangeli, Antonella, Velardi, Elisabetta, Di Cello, Cristina, Rosati, Nadia, Casali, Maria, Sessa, Luciano, Abruzzi, Chiara, Costanzi, Bini, Paolo, Pignata, Michele, Enrico, Buonagurio, Maria, Vollery, Giovanni, Carrieri, Giorgio, Cioni, Andrea, Toschi, Marco, Metra, Piera, Ranieri, Alberto, Zucchelli, Ceccon, Anna, Magrin, Laura, Marin, Sara, Barbara, Sofia, Marco, Masina, Laura, Ghedini, Matteo, Moroni, Marco, Paragona, Caterina, Pallotti Maria, Carla, Rota, Federica, Gottardi, Clara, Tomasoni, Melania, Cappuccio, Giampaolo, Bonini, Stefano, Guerini, Valeria, Guerini, Lucia, Merla, Giovambattista, Desideri, Ester, Liberatore, Cecilia, Carucci Anna, Maurizio, Tovaglieri, Vera, Renna Frandesca, Nadia, Bongiorni, Grillo, Antonio, Arenare, Francesca, Tonino, Mineo, David, Kanah, Giorgio, Vianello Piero, Ubaldo, Balducci, Vincenzo, Sidoti, Stefano, Montanari, Marino, Formilan, Busonera Flavio, Murelli Teodolindo, Paolo, Albanese, Monica, Maselli, Francesco, Bolzetta, Roberto, Fabris, Paolo, Bonino, DuranteMangoni, Emanuele, Testoni, Michela, Fabio, Di Stefano, Loredana, Seccia, Valeria, Sonzini, Fabiano, Maria, Annabella, Di Giorgio, Salvatore, De Cosmo, Greco, Antonio, Grazia, D'Onofrio, Daniele, Sancarlo, Gianluca, Resta, Renzo, Girardello, Sergio, Minervini, Morena, Boni, Vitali, Mariagrazia, Marina, Pizzoni, Paolo, De Colle, Cristina, Scarpa, Alessandra, Frattola, Orlandini, Francesco, La Regina, Micaela, Desirée, Addesi, Mirella, Filippo, Mario, Bo, Paola, Porrino, Padulo, Filomena, Cristina, Margheriti, Dario, Rolano, Giancarla, Moscatelli, Guido, Radaelli, Elena, Montini, Prete, Cosimo, Marileda, Novello, Igor, Bramuzzo, Nicole, Bertin, Elena, Rinaldo, Paolillo, Ciro, Riccardi, Angela, Claudia, Benedetti, Barbara, Rizzi, Francesca, Montagna, Silvia, Vitali, Chiara, Cutaia, Oliver, Baca, Mauro, Colombo, Eleonora, Marelli, Giuseppe, Procino, Rosaria, Tararà, Maria, Cottino, Davide, Dell'Acqua, Stefania, Cislaghi, Marco, Cairati, Massimo, Porta, Luca, Scaglione, Martina, De Feo, Paola, Vertolli, Lia, Salvati, Sandro, Cinotti, Valentina, De Santis, Erminia, Biferi, Paola, Cheli, Romina, Rebizzo, Minisola, Salvatore, Luciano, Colangelo, Pasquale, Abete, Ilaria, Liguori, Francesca, Curcio, Guglielmo, Spassini, Marco, Engheben, Sara, Rotunno, Paola, Arosio, Claudio, Angelini, Francesco, Reggiani, Alessandro, Cappelli, Simona, Marcheselli, Lara, Fratticci, Paola, Ranzani, Simonetta, Cesarini, Antonella, Cerini, Generoso, Uomo, Fernando, Gallucci, Giuliano, Ceschia, Emanuela, Serra, Mariolina, Sola, Alessandro, Delitala, Chiara, Pes, Giulia, Lobianco, Alessandro, Giani, Famularo, Simone, Sandini, Marta, Pinotti, Enrico, Gianotti, Luca, Antonella, Battuello, Giulia, Pintore, Sante, Giardini, Rossi, Andrea, Rubele, Sofia, Sant, Selena, Marco, Vignati, Danila, Clerici, Fabio, Rosa, Bandirali, Maria Pia, Nicoletta, Cattaneo, Laura, Boffi, Paolo, Tosoni, Luciano, Terranova, Leonello, Avalli, Margherita, Scanziani, Stefania, De Notaris, Pierluigi, Del Santo, Laura, Rossi, Fabiana, Tezza, Giovanna, Cervati, Antonino, Andreolli, Felice, Catalano, Giuseppe, Burattin, Danilo, Fogli, Giovanna, Di Bella, Francesco, Landi, Salini, Sara, Angela, Brunetti Maria, Giorgetta, Cappa, Giovanni, Galvagno, Paola, Cena, Gerardo, Bruno, Silvio, Raspo, Letizia, Semeraro, Sabrina, Pedrotti, Davide, Barra, Rosaria, Rizzo Maria, Maria, Dalise Anna, Raffaele, Prestano, Palmieri, Vincenzo Ostilio, Palasciano, Giuseppe, Belfiore, Anna, Portincasa, Piero, Carlo, Sabbà, Vincenzo, Solfrizzi, Alessia, D'introno, Valiani, Vincenzo, Carolina, Bologna, Tiziana, Ciarambino, Paola, Turelli, Ugo, Pazzaglia, Federica, Rodella, Giacomo, Piana, Castellano, Maurizio, Anna, Garelli, Elisa, Casella, Federica, Campana, Antonietta, Coschignano Maria, Luigi, Marinangeli, Fabio, Lorico, Salvatore, Bazzano, Giuseppe, Menculini, Gelosa, Giorgio, Viviana, Ambrogio Teresa, Piras, Valentina, Andrea, Ciricugno, Alessandra, Bollari, Coen, Daniele, Magliola, Renata, Milanesio, Deborah, Muzzulini, Carlo Lorenzo, Paolo, Fogliacco, Marinella, Turla, Sofia, Cotelli Maria, Marta, Bianchi, Siano, Pietro, Capo, Giuseppe, Napoletano, Rosa, Cecilia, Politi, Mancini, Concetta, Del Buono, Corrado, De Bartolomeo, Giuseppe, Addolorata, Martinelli, Carmen, Cefalogli, Roberto, Cozzi, Giovanni, Virtuani Angelo, Moschettini, Gianfilippo, Franco, Mastroianni, Daniela, Roglia, D'Amico, Gabriella, Mirella, Palella, Endrizzi, Cristina, Trotta, Lucia, Ciarambino, Tiziana, Orazio, Zanetti, Emanuela, Terazzi, Marta, Sacchetti, Thomas, Fleetwood, Giacomo, Tondo, Ignazio, Di Fazio, Andrea, Bruni, Giuseppe, Orsitto, Emanuela, Fabbro, Serena, Amici, Elena, D'Imporzano, Anna, Casanova, Serena, Bertolio, Erika, Nervo, Roberto, Silvestri, Elena, Semproni, Manuela, Pintus, Francesca, Aloe, Angelo, Tagliaccica, Zambon, Antonella, and Di Santo, Simona G.

Published
2020
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166. Dietary Patterns and Mortality in a Multinational Cohort of Adults Receiving Hemodialysis

Author

Badino, A., Petracci, L., Villareal, C., Soto, M., Arias, M., Vera, F., Quispe, V., Morales, S., Bueno, D., Bargna, R., Peñaloza, G., Alcalde, L., Dayer, J., Milán, A., Centurión, N., Ramos, A., De Orta, E., Menardi, S., Austa Bel, N., Marileo, E., Junqueras, N., Favalli, C., Trioni, R., Valle, G., López, M., Marinaro, C., Fernandez, A., Corral, J., Nattiello, E., Marone, S., García, J., Carrizo, G., González, P., Delicia, O., Maza, M., Chauque, M., Mora, J., Grbavac, D., López, L., Alonso, M., Villalba, C., Simon, M., Cernadas, M., Moscatelli, C., Vilamajó, I., Tursky, C., Martínez, M., Villalba, F., Pereira, D., Araujo, S., López, H., Alonso, V., Vázquez, B., Rapetti, M., Raña, S., Capdevila, M., Ljubich, C., Acosta, M., Coombes, M., Doria, V., Ávila, M., Cáceres, D., Geandet, E., Romero, C., Morales, E., Recalde, C., Casanú, M., Lococo, B., Da Cruz, O., Focsaner, C., Galarce, D., Albarracín, L., Vescovo, E., Gravielle, M., Florio, D., Baumgart, L., Corbalán, M., Aguilera, V., Hermida, O., Galli, C., Ziombra, L., Gutierrez, A., Frydelund, S., Hardaman, A., Maciel, A., Arrigo, M., Mato Mira, C., Leibovich, J., Paparone, R., Muller, E., Malimar, A., Leocadio, I., Cruz, W., Tirado, S., Peñalba, A., Cejas, R., Mansilla, S., Campos, C., Abrego, E., Chávez, P., Corpacci, G., Echavarría, A., Engler, C., Vergara, P., Hubeli, M., Redondo, G., Noroña, B., Boriceanu, C., Lankester, M., Poignet, J.L., Saingra, Y., Indreies, M., Santini, J., Mahi, A., Robert, A., Bouvier, P., Merzouk, T., Villemain, F., Pajot, A., Tollis, F., Brahim-Bounab, M., Benmoussa, A., Albitar, S., Guimont, M.C., Ciobotaru, P., Guerin, A., Diaconita, M., Hoischen, S.H., Saupe, J., Ullmann, I., Grosser, S., Kunow, J., Grueger, S., Bischoff, D., Benders, J., Worch, P., Pfab, T., Kamin, N., Roesch, M., May, M., Albert, K., Csaszar, I., Kiss, E., Kosa, D., Orosz, A., Redl, J., Kovacs, L., Varga, E., Szabo, M., Magyar, K., Zajko, E., Bereczki, A., Csikos, J., Kerekes, E., Mike, A., Steiner, K., Nemeth, E., Tolnai, K., Toth, A., Vinczene, J., Szummer, S.z., Tanyi, E., Szilvia, M., Murgo, A.M., Sanfilippo, N., Dambrosio, N., Saturno, C., Matera, G., Benevento, M., Greco, V., di Leo, G., Papagni, S., Alicino, F., Marangelli, A., Pedone, F., Cagnazzo, A.V., Antinoro, R., Sambati, M.L., Donatelli, C., Ranieri, F., Torsello, F., Steri, P., Riccardi, C., Flammini, A., Moscardelli, L., Boccia, E., Mantuano, M., Di Toro Mammarella, R., Meconizzi, M., Fichera, R., D’Angelo, A., Latassa, G., Molino, A., Fici, M., Lupo, A., Montalto, G., Messina, S., Capostagno, C., Randazzo, G., Pagano, S., Marino, G., Rallo, D., Maniscalco, A., Trovato, O.M., Strano, C., Failla, A., Bua, A., Campo, S., Nasisi, P., Salerno, A., Laudani, S., Grippaldi, F., Bertino, D., Di Benedetto, D.V., Puglisi, A., Chiarenza, S., Lentini Deuscit, M., Incardona, C.M., Scuto, G., Todaro, C., Dino, A., Novello, D., Coco, A., Bocheńska-Nowacka, E., Jaroszyński, A., Drabik, J., Wypych-Birecka, M., Daniewska, D., Drobisz, M., Doskocz, K., Wyrwicz-Zielińska, G., Kosicki, A., Ślizień, W., Rutkowski, P., Arentowicz, S., Dzimira, S., Grabowska, M., Ostrowski, J., Całka, A., Grzegorczyk, T., Dżugan, W., Mazur, M., Myślicki, M., Piechowska, M., Kozicka, D., de Sá Martins, V., Aguiar, L., Mira, A.R., Velez, B., Pinheiro, T., Agapi, E., Ardelean, C.L., Baidog, A., Bako, G., Barb, M., Blaga, A., Bodurian, E., Bumbea, V., Dragan, E., Dumitrache, D., Florescu, L., Havasi, N., Hint, S., Ilies, R., Mandita, A.G.M., Marian, R.I., Medrihan, S.L., Mitea, L., Mitea, S., Mocanu, R., Moro, D.C., Nitu, M., Popa, M.L., Popa, M., Railean, E., Scuturdean, A.R., Szentendrey, K., Teodoru, C.L., Varga, A., García, M., Olaya, M., Abujder, V., Carreras, J., López, A., Ros, F., Cuesta, G., García, A., Orero, E., Ros, E., Bea, S., Pizarro, J.L., Luengo, S., Romero, A., Navarro, M., Cermeño, L., Rodriguez, A., Lopez, D., Barrera, A., Montoya, F., Tajahuerce, J., Carro, M., Cunill, M.Q., Narci, S., Ballester, T., Soler, M.J., Traver, S., Buta, P.P., Cucuiat, L., Rosu, L., Garcia, I., Gavra, C.M., Gonzalez, R., Filimon, S., Peñalver, M., Benages, V., Cardo, M.I., García, E., Soler, P., Fernnandez, E., Popescu, F., Munteanu, R., Tanase, E., Sagau, F., Prades, D., Esteller, S., Gonzalez, E., Martinez, R., Diago, A., Torres, J., Perez, E., Garcia, C., Lluch, I., Forcano, J., Fóns, M., Rodríguez, A., Millán, N.A., Fernández, J., Ferreiro, B., Otero, M., Pesqueira, V., Abal, S., Álvarez, R., Jorge, C., Rico, I., de Dios Ramiro, J., Duzy, L., Soto, A., Lopez, J.L., Diaz, Y., Herrero, I., Farré, M., Blasco, C., Ferrás, S., Agost, M.J., Miracle, C., Farto, J., Goch, J., Katzarski, K.S., Wulcan, A., Akbiber, H., Arslan, H., Bicen, L., Buyukkiraz, A., Celik, R., Dogan, I.S., Erkalkan, S., Ertas, A., Hark, U., Iravul, E., Karakaya, M., Mengu, K., Ongun, S., Ozkan, Z., Ozlu, A., Ozveren, N., Sifil, H.M., Sonmez Turksoz, N., Yilmaz, Z., Saglimbene, Valeria M., Wong, Germaine, Teixeira-Pinto, Armando, Ruospo, Marinella, Garcia-Larsen, Vanessa, Palmer, Suetonia C., Natale, Patrizia, Campbell, Katrina, Carrero, Juan-Jesus, Stenvinkel, Peter, Gargano, Letizia, Murgo, Angelo M., Johnson, David W., Tonelli, Marcello, Gelfman, Rubén, Celia, Eduardo, Ecder, Tevfik, Bernat, Amparo G., Del Castillo, Domingo, Timofte, Delia, Török, Marietta, Bednarek-Skublewska, Anna, Duława, Jan, Stroumza, Paul, Hansis, Martin, Fabricius, Elisabeth, Felaco, Paolo, Wollheim, Charlotta, Hegbrant, Jörgen, Craig, Jonathan C., and Strippoli, Giovanni F.M.

Published
2020
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174. Vacuolar Proton-Translocating ATPase May Take Part in the Drug Resistance Phenotype of Glioma Stem Cells

Author

Giambra, Martina, primary, Di Cristofori, Andrea, additional, Raimondo, Francesca, additional, Rigolio, Roberta, additional, Conconi, Donatella, additional, Chiarello, Gaia, additional, Tabano, Silvia Maria, additional, Antolini, Laura, additional, Nicolini, Gabriella, additional, Bua, Miriam, additional, Ferlito, Davide, additional, Carrabba, Giorgio, additional, Giussani, Carlo Giorgio, additional, Lavitrano, Marialuisa, additional, and Bentivegna, Angela, additional

Published
2024
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177. V-ATPase Proton Pump May Take Part to Drug-Resistance Phenotype of Glioma Stem Cells

Author

Giambra, Martina, primary, Di Cristofori, Andrea, additional, Raimondo, Francesca, additional, Rigolio, Roberta, additional, Conconi, Donatella, additional, Chiarello, Gaia, additional, Tabano, Silvia Maria, additional, Antolini, Laura, additional, Nicolini, Gabriella, additional, Bua, Miriam, additional, Ferlito, Davide, additional, Carrabba, Giorgio, additional, Giussani, Carlo Giorgio, additional, Lavitrano, Marialuisa, additional, and Bentivegna, Angela, additional

Published
2024
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181. Development of In–Cu binary oxide catalysts for hydrogenating CO2via thermocatalytic and electrocatalytic routes

Author

Mezzapesa, Marco Pietro, primary, Salomone, Fabio, additional, Guzmán, Hilmar, additional, Zammillo, Federica, additional, Millini, Roberto, additional, Bua, Letizia, additional, Marra, Gianluigi, additional, Tacca, Alessandra, additional, Marrazzo, Rosamaria, additional, Russo, Nunzio, additional, Pirone, Raffaele, additional, Hernández, Simelys, additional, and Bensaid, Samir, additional

Published
2024
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183. Symmetries in Lagrangian Field Theory

Author

Búa, Lucía, Bucataru, Ioan, de León, Manuel, Salgado, Modesto, and Vilariño, Silvia

Subjects
Mathematical Physics
Abstract

By generalizing the cosymplectic setting for time-dependent Lagrangian mechanics, we propose a geometric framework for the Lagrangian formulation of classical field theories with a Lagrangian depending on the independent variables. For that purpose we consider the first order jet bundles $J^1\pi$ of a fiber bundle $\pi:E\to {\mathbb R}^k$ where ${\mathbb R}^k$ is the space of independent variables. Generalized symmetries of the Lagrangian are introduced and the corresponding Noether Theorem is proved., Comment: 26 pages, pre-published version in Reports on Mathematical Physics, 2015

Published
2014
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185. Influence of School Environment on the Management of Secondary School Education in Makurdi Metropolis of Benue State, Nigeria

Author

Bua, Felix Terhile

Abstract

The study investigated the influence of school environment on the management of secondary school education in Makurdi Metropolis of Benue State. Two research questions and two hypotheses guided the study. The survey design was adopted for the study. Four hundred (400) teachers from 20 grant aided secondary schools in Markurdi Metropolis of Benue state constituted the sample for the study. The study selected its respondents using simple random sampling technique. A structured 10-item four point rating scale questionnaire titled "Influence of School Environment on Management of Secondary School Questionnaire" (ISEMSSQ) was constructed by the researchers and used to collect data for the study. The data collected were analyzed using frequency counts, percentages, mean and standard deviation to answer research questions while chi-square (x[superscript 2]) test of goodness of fit was deployed to test the hypotheses at p<0.05 level of significance. The study revealed that there was a significant influence of leadership style and school-community relations on secondary schools in Makurdi metropolis of Benue state. It was recommended that School heads or administrators should adopt the most appropriate leadership style based on school situation for effective management of their environment and that schools host communities be considered in the running of schools, especially in matters concerning students' welfare.

Published
2013

186. S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors

Author

Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Hany E. A. Ahmed, and Claudiu T. Supuran

Subjects
metalloenzyme, quinazolinone incorporating ethylsulfonamide, selectivity ca inhibitors, molecular docking study, Therapeutics. Pharmacology, RM1-950
Abstract

We evaluated the hCA (CA, EC 4.2.1.1) inhibitory activity of novel 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides (compounds 2–20) towards the isoforms I, II, IX, and XII. hCA Isoforms were effectively inhibited by most of new compounds comparable to those of AAZ. Compounds 2 and 4 showed interestingly efficient and selective antitumor (hCA IX and hCA XII) inhibitor activities (KIs; 40.7, 13.0, and 8.0, 10.8 nM, respectively). Compounds 4 and 5 showed selective hCA IX inhibitory activity over hCA I (SI; 95 and 24), hCA IX/hCA II (SI; 23 and 5.8) and selective hCA XII inhibitory activity over hCA I (SI; 70 and 44), hCA XII/hCA II, (SI; 17 and 10) respectively compared to AAZ. Compounds 12–17, and 19–20 showed selective inhibitory activity towards hCA IX over hCA I and hCA II, with selectivity ranges of 27–195 and 3.2–19, respectively, while compounds 12, 14–17, and 19 exhibited selective inhibition towards hCA XII over hCA I and hCA II, with selectivity ratios of 48–158 and 5.4–31 respectively, compared to AAZ. Molecular docking analysis was carried out to investigate the selective interactions among the most active derivatives, 17 and 20 and hCAs isoenzymes. Compounds 17 and 20, which are highly selective CA IX and XII inhibitors, exhibited excellent interaction within the putative binding site of both enzymes, comparable to the co-crystallized inhibitors.Highlights Quinazoline-linked ethylbenzenesulfonamides inhibiting CA were synthesised. The new molecules potently inhibited the hCA isoforms I, II, IV, and IX. Compounds 4 and 5 were found to be selective hCA IX/hCA I and hCA IX/hCA II inhibitors. Compounds 4 and 5 were found to be selective hCA XII/hCA I and hCA XII/hCA II inhibitors. Compounds 12–17, 19, and 20 were found to be selective hCA IX/hCA I and hCA IX/hCA II inhibitors. Compounds 12, 14–17, 19 were found to be selective hCA XII/hCA I and hCA XII/hCA II inhibitors. Graphical Abstract Compounds 4 and 5 are selective hCA IX and XII inhibitors over hCA I (selectivity ratios of 95, 23, and 24, 5.8, respectively) and hCA II (selectivity ratios of 70, 17, and 44, 10 respectively). Compounds 12–17, and 19–20 are selective hCA IX inhibitors over hCA I (selectivity ratios of 27-195) and hCA II (selectivity ratios of 3.2-19). Compounds 12, 14–17 and 19 are also selective hCA XII inhibitors over hCA I (selectivity ratios of 48-158) and hCA II (selectivity ratios of 5.4-31).

Published
2020
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187. Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors

Author

Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hany E. A. Ahmed, Sivia Bua, Alessio Nocentini, Nawaf A. AlSaif, Ahmad J. Obaidullah, Mohamed M. Hefnawy, and Claudiu T. Supuran

Subjects
metalloenzyme, quinazolinone, sulphonamide, inhibition, selectivity, molecular docking study, Therapeutics. Pharmacology, RM1-950
Abstract

Inhibitory action of newly synthesised 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides compounds 2–13 against human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII, was evaluated. hCA I was efficiently inhibited by compounds 2–13 with inhibition constants (KIs) ranging from 57.8–740.2 nM. Compounds 2, 3, 4, and 12 showed inhibitory action against hCA II with KIs between 6.4 and 14.2 nM. CA IX exhibited significant sensitivity to inhibition by derivatives 2–13 with KI values ranging from 7.1 to 93.6 nM. Compounds 2, 3, 4, 8, 9, and 12 also exerted potent inhibitory action against hCA XII (KIs ranging from 3.1 to 20.2 nM). Molecular docking studies for the most potent compounds 2 and 3 were conducted to exhibit the binding mode towards hCA isoforms as a promising step for SAR analyses which showed similar interaction with co-crystallized ligands. As such, a subset of these mercaptoquinazolin-4(3H)-one compounds represented interesting leads for developing new efficient and selective carbonic anhydrase inhibitors (CAIs) for the management of a variety of diseases including glaucoma, epilepsy, arthritis and cancer.

Published
2020
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188. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors

Author

Sonia Del Prete, Silvia Bua, Claudiu T. Supuran, and Clemente Capasso

Subjects
carbonic anhydrase, sulphonamides, inhibitors, antibacterials, escherichia coli, Therapeutics. Pharmacology, RM1-950
Abstract

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes involved in biosynthetic processes, transport, supply, and balance of CO2/HCO3- into the cell. In Bacteria, CAs avoid the depletion of the dissolved CO2/HCO3- from the cell, providing them to the central metabolism that is compromised without the CA activity. The involvement of CAs in the survival, pathogenicity, and virulence of several bacterial pathogenic species is recent. Here, we report the kinetic properties of the recombinant γ-CA (EcoCAγ) encoded in the genome of Escherichia coli. EcoCAγ is an excellent catalyst for the physiological CO2 hydration reaction to bicarbonate and protons, with a kcat of 5.7 × 105 s−1 and kcat/KM of 6.9 × 106 M−1 s−1. The EcoCAγ inhibition profile with a broad series of known CA inhibitors, the substituted benzene-sulphonamides, and clinically licenced drugs was explored. Benzolamide showed a KI lower than 100 nM. Our study reinforces the hypothesis that the synthesis of new drugs capable of interfering selectively with the bacterial CA activity, avoiding the inhibition of the human α -CAs, is achievable and may lead to novel antibacterials.

Published
2020
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189. Sulphonamide inhibition profile of Staphylococcus aureus β-carbonic anhydrase

Author

Linda J. Urbanski, Silvia Bua, Andrea Angeli, Marianne Kuuslahti, Vesa. P. Hytönen, Claudiu T. Supuran, and Seppo Parkkila

Subjects
β-carbonic anhydrase, staphylococcus aureus, kinetics, inhibition, sulphonamides, Therapeutics. Pharmacology, RM1-950
Abstract

This paper presents the production and kinetic and inhibitory characterisation of β-carbonic anhydrase from the opportunistic bacterium Staphylococcus aureus (SauBCA). From the eight different carbonic anhydrase (CA) families known to date, humans have only the α-form, whereas many clinically relevant pathogens have β- and/or γ-form(s). Based on this discovery, β- and γ-CAs have been introduced as promising new anti-infective targets. The results of this study revealed that recombinant SauBCA possesses significant CO2 hydration activity with a kcat of 1.46 × 105 s−1 and a kcat/KM of 2.56 × 107 s− 1M−1. Its enzymatic function was inhibited by various sulphonamides in the nanomolar − micromolar range, and the Ki of acetazolamide was 628 nM. The best inhibitor was the clinically used sulfamide agent famotidine (Ki of 71 nM). The least efficient inhibitors were zonisamide and dorzolamide. Our work encourages further investigations of SauBCA in an attempt to discover novel drugs against staphylococcal infections.

Published
2020
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190. Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases

Author

Ashok Aspatwar, Emanuela Berrino, Silvia Bua, Fabrizio Carta, Clemente Capasso, Seppo Parkkila, and Claudiu T. Supuran

Subjects
carbonic anhydrases, inhibitors, toxicity screening, zebrafish, Therapeutics. Pharmacology, RM1-950
Abstract

Here, we report a toxicity study, conducted on zebrafish larvae, of a series of coumarin and sulfamide compounds that were previously reported as inhibitors of human (h) metalloenzymes, carbonic anhydrases (CAs, EC 4.2.1.1). Due to the high relevance of hCA inhibitors as theragnostic agents, it is of pivotal importance to address safety issues that may arise from the initial in vivo toxicological assessment using zebrafish, a relevant model for biomedical research. None of the reported compounds showed adverse phenotypic effects or tissue damage on developing zebrafish larvae after 5 days of exposure. Our study suggests that the coumarin and sulfamide derivatives considered here are safe and suitable for further development and testing.

Published
2020
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191. Health professionals’ readiness to implement electronic medical recording system and associated factors in public general hospitals of Sidama region, Ethiopia

Author

Kibruyisfaw Weldeab Abore, Alemu Tamiso Debiso, Betelhem Eshetu Birhanu, Bezahegn Zerihun Bua, and Keneni Gutema Negeri

Subjects
Medicine, Science
Abstract

Background Electronic medical recording system is one of the information technologies that has a proven benefit to improve the quality of health service. Readiness assessment is one of the recommended steps to be taken prior to implementing electronic medical recording system to reduce the probability of failure. Objective To determine the level of health professional readiness to implement Electronic medical recording system and associated factors in public general hospitals of Sidama region, 2022. Methodology A cross-sectional study design complemented with qualitative study was employed at three public general hospitals in Sidama region on a sample of 306 participants. A pretested self-administered questionnaire was used to collect quantitative data and in-depth interview was used for the qualitative study. Bivariate and multivariate Binary logistics regression was performed to determine predictors of readiness at α = 0.05, using an odds ratio and 95% confidence interval. Thematic analysis was done for qualitative data collected through in-depth interview. Result The overall readiness for health professionals was 36.5%. Of the study participants, 201 (73.4%) were computer literate, 176(64.23%) had good knowledge, and 204 (74.45%) had favorable attitude towards EMR. Only 31 participants had previous training (11.3%), while 64 (23%) had previous experience. EMR knowledge (AOR = 3.332; 95%CI: (1.662, 6.682)) and attitude towards electronic medical recording (AOR = 2.432; 95%CI: (1.146, 5.159)) were statistically significant predictors of readiness to implement electronic medical recording. Qualitative analysis has revealed lack of training, ease of use concerns, information security concerns, and perceived inadequacy of infrastructures including internet connectivity and electricity as common barriers for health professional readiness to implement EMR. Conclusion Health professionals’ readiness in this study was low. Capacity building efforts to increase the awareness and skills of health professionals should be done before implementing the system.

Published
2022

193. Finite Element Prediction on Fracture Load of Femur with Osteogenesis Imperfecta under Various Loading Conditions

Author

Soh Bua Chai Wanna, Khairul Salleh Basaruddin, Fauziah Mat, Mohd Hanafi Mat Som, and Abdul Razak Sulaiman

Subjects
Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5
Abstract

Osteogenesis Imperfecta (OI) is an inherited disorder characterized by extreme bone fragility due to collagen defects. It is an incurable disease. Bone fractures can occur frequently without prior notice, especially among children. Early quantitative prediction of fracture loads due to OI tends to alert patients to avoid unnecessary situations or dangerous conditions. This study is aimed at investigating the fracture loads of femur with OI under various types of loading. Ten finite element models of an OI-affected bone were reconstructed from the normal femur with different bowing angles ranging from 7.5 to 30.0°. The boundary conditions were assigned on an OI-affected femoral head under three types of load: medial-lateral impacts, compression-tension, and internal-external torsions, and various loading direction cases that reflect the stance condition. The fracture load was examined based on the load that can cause bone fracture for each case. The results show that the loads bearable by the femur before fracture were decreased with respect to the increase of OI bowing angles in most of the loading cases. The risk of fracture for the femur with OI was directly proportional to the increase of bowing angles in the frontal plane. This study provides new insights on fracture load prediction in OI-affected bone with respect to various loading types, which could help medical personnel for surgical intervention judgement.

Published
2022
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195. Outcomes of Posterior Malleolar Fixation in Ankle Fractures in A Major Trauma Centre

Author

Nelson Bua, Luckshmana A. Jeyaseelan, Lee Parker FRCS(Tr&Orth), Amaury Trockels, Catrin Sohrabi, Alexandros Vris, Nima Heidari, and Francesc Malagelada Romans

Subjects
Orthopedic surgery, RD701-811
Abstract

Category: Ankle; Trauma Introduction/Purpose: Ongoing controversy exists over the indications and benefits of posterior malleolar fixation in ankle fractures. These injuries require careful evaluation of the bony and ligamentous structures with theoretical benefits of posterior malleolar fixation now widely accepted as restoration of articular congruity, restoration of fibular length and stabilisation of the syndesmosis. Surgical and patient report outcomes are varied in the literature with analysis limited by the lack of standardisation in functional outcomes and small patient populations. Posterior malleolar fixation does extend operative time and potentially increases complication rate. The aim of this pragmatic study was to evaluate the outcomes of posterior malleolar fracture fixation in the setting of a major trauma centre. Our hypothesis is that posterior malleolus fixation leads to improved clinical outcomes. Methods: A total of 320 patients were identified with operatively treated ankle fractures involving a posterior malleolus component, between January 2012 and January 2018, with minimum 2 year follow-up. Patient electronic records were assessed for demographic data including age, gender, mechanism of injury, co-morbidities and smoking status. Pre-operative imaging, including CT was used to evaluate the nature of the injury and classify the posterior malleolar fracture according to the Mason classification. One hundred and sixty patients underwent posterior malleolus fixation as part of their surgery and 160 patients did not. The Manchester-Oxford Foot Questionnaire (MOXFQ) at final follow-up, was the primary patient outcome measure.Complications were noted to be minor (superficial infection or delayed wound healing) or major (DVT/PE, deep infection, chronic regional pain syndrome (CRPS), arthrofibrosis, further intervention for post-traumatic arthritis, hardware failure or irritation). All cause reoperation rates were also noted. Results: Fixation of the posterior malleolus was associated with a statistically significant improvement in patient outcomes. Mean MOXFQ score in the unfixed posterior malleolus group was 24.03 (0 - 62), compared to 20.10 (0 - 67) in the fixed posterior malleolus group (p =0.04). Outcomes were worse with increasing size of posterior malleolar fragment. When compared with either posterior malleolus fixation alone or syndesmotic stabilisation alone, poorer outcomes were seen when the posterior malleolus fixed with additional syndesmotic stabilisation, with mean MOXFQ scores of 21.73 (0-60), p =0.057. Metalwork-related issues were higher in the posterior malleolus fixed group (24/160 (15%) versus 10/160 (6.2%), p=0.03). Re-operation rate was double (34/160 (21.2%) vs 16/160 (10%), p = 0.03). The main cause of this was hardware related issues. Conclusion: This pragmatic study is one of the largest published series that assesses patient reported outcomes in posterior malleolar fixation. The key finding is that posterior malleolar fixation is associated with a statistically significant improvement in patient reported outcome scores. However, the overall complication rate was 10.7% higher in the fixation group and the risk of reoperation was over double. Further research should focus on high quality randomised controlled trials with long term follow-up to assess long term impacts of this complex ankle injury pattern.

Published
2022
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196. Functional Outcomes of Dorsal Bridge Plating for Lisfranc Injuries with Routine Metalwork Retention: A Major Trauma Centre Experience

Author

Elliot I. Onochie, Nelson Bua, Amit Patel FRCS(Orth), Shilpa Jha MBBS, MRCS, Nima Heidari, Alexandros Vris, Lee Parker FRCS(Tr&Orth), Francesc Malagelada Romans, and Luckshmana A. Jeyaseelan

Subjects
Orthopedic surgery, RD701-811
Abstract

Category: Midfoot/Forefoot; Trauma Introduction/Purpose: Lisfranc injuries represent a significant disruption to the complex articulations of the midfoot. Many of these injuries are unstable with displacement and articular incongruity. This necessitates surgical intervention with the primary goals of anatomic reduction and midfoot stability. Evidence around surgical treatments for Lisfranc complex injuries is limited by heterogeneity in outcome measures and small patient numbers. Dorsal bridge plating is a well-recognized surgical technique with the benefits of rigid stability and joint preservation. The primary aim of this study is to assess the midterm functional outcomes for patients treated with this technique at our major trauma centre. Additionally, we assess the complication profile and review for risk factors that influence the functional outcome. Methods: Eighty-five adult patients were identified as undergoing open reduction and dorsal bridge plate fixation for displaced, unstable Lisfranc injuries at our major trauma centre between January 2014 and January 2018. Supplemental Kirschner wire stabilization was used for the lateral column if necessitated by the injury pattern. Importantly, metalwork was not routinely removed. A retrospective review of case notes and imaging was conducted in order to collate demographic data including co- morbidities and smoking status. Patient-reported outcome measures were collected at final follow-up, with a minimum follow-up of 24 months. The Manchester-Oxford Foot Questionnaire summary index (MOXFQ-Index) was the primary patient-reported outcome. The American Orthopaedic Foot & Ankle Society (AOFAS) midfoot scale, complications, and all-cause re-operation rates were secondary outcome measures. Univariate and multivariate analyses were used to identify risk factors associated with poorer functional outcomes. Results: The mean follow-up in this study was 40.8 months (24 - 72). 61/85 patients (72%) had high-energy or crush mechanisms of injury. The mean MOXFQ-Index was 27.0 (SD 7.1). The mean AOFAS score was 72.6 (SD 11.6). 48/85 patients (56%) had injury patterns that included an intra-articular fracture and this was associated with poorer outcomes, with worse MOXFQ and AOFAS scores (both p

Published
2022
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197. Life Cycle Assessment of Luminescent Solar Concentrators Integrated into a Smart Window

Author

Vincenzo Muteri, Sonia Longo, Marzia Traverso, Elisabetta Palumbo, Letizia Bua, Maurizio Cellura, Daniele Testa, and Francesco Guarino

Subjects
life cycle assessment, smart windows, photovoltaic technologies, luminescent solar concentrator, Technology
Abstract

The main goal of this paper is to assess the life cycle environmental impacts of a multifunctional smart window luminescent solar concentrator (SW–LSC) prototype through the application of the Life Cycle Assessment methodology. To the authors’ knowledge, this is one of the first studies on the topic. The analysis followed a cradle to gate approach, considering the assembly and maintenance phase as well as the end of life, examined separately through a recycling/landfill scenario. A comparison of the impacts of LSC modules with those of some building-integrated photovoltaic technologies was carried out. Results showed that the global warming potential (100 years) for SW–LSC was 5.91 × 103 kg CO2eq and the manufacturing phase had the greatest impact (about 96%). The recycling/landfill scenario results showed the possibility to reduce impacts by an average of 45%. A dominance analysis of SW–LSC components showed that the aluminum frame was the main hotspot (about 60% contribution), followed by the light-shelf (about 19%). Batteries and motors for the shading system were the biggest contributors in the abiotic depletion potential category (36% and 30%, respectively). An alternative scenario, which involved the use of 75% recycled aluminum for the window frame, highlighted the possibility to reduce environmental impacts from 3% to 46%. Finally, the comparison results showed that the LSC modules’ impacts were on average 870% lower than that of various PV technologies when compared on the basis of m2; on the contrary, LSC modules had the highest impacts in all categories (from 200% to 1900%) when compared with other PV technologies on the basis of 1 kWh of energy generated. The results could be used for the definition of eco-design strategies for the examined device, in order to support the scaling-up process and to put “greener” systems onto the market.

Published
2023
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198. Next Generation Sequencing for the Analysis of Parvovirus B19 Genomic Diversity

Author

Federica Bichicchi, Niccolò Guglietta, Arthur Daniel Rocha Alves, Erika Fasano, Elisabetta Manaresi, Gloria Bua, and Giorgio Gallinella

Subjects
Parvovirus B19, genetic diversity, viral quasispecies, Next Generation Sequencing, Shannon Entropy, cluster analysis, Microbiology, QR1-502
Abstract

Parvovirus B19 (B19V) is a ssDNA human virus, responsible for an ample range of clinical manifestations. Sequencing of B19V DNA from clinical samples is frequently reported in the literature to assign genotype (genotypes 1–3) and for finer molecular epidemiological tracing. The increasing availability of Next Generation Sequencing (NGS) with its depth of coverage potentially yields information on intrinsic sequence heterogeneity; however, integration of this information in analysis of sequence variation is not routinely obtained. The present work investigated genomic sequence heterogeneity within and between B19V isolates by application of NGS techniques, and by the development of a novel dedicated bioinformatic tool and analysis pipeline, yielding information on two newly defined parameters. The first, α-diversity, is a measure of the amount and distribution of position-specific, normalised Shannon Entropy, as a measure of intra-sample sequence heterogeneity. The second, σ-diversity, is a measure of the amount of inter-sample sequence heterogeneity, also incorporating information on α-diversity. Based on these indexes, further cluster analysis can be performed. A set of 24 high-titre viraemic samples was investigated. Of these, 23 samples were genotype 1 and one sample was genotype 2. Genotype 1 isolates showed low α-diversity values, with only a few samples showing distinct position-specific polymorphisms; a few genetically related clusters emerged when analysing inter-sample distances, correlated to the year of isolation; the single genotype 2 isolate showed the highest α-diversity, even if not presenting polymorphisms, and was an evident outlier when analysing inter-sample distance. In conclusion, NGS analysis and the bioinformatic tool and pipeline developed and used in the present work can be considered effective tools for investigating sequence diversity, an observable parameter that can be incorporated into the quasispecies theory framework to yield a better insight into viral evolution dynamics.

Published
2023
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