4,902 results on '"Bruix"'
Search Results
152. Resection vs. transplantation for hepatocellular carcinoma: a never ending challenge
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Ferrer-Fàbrega, Joana, primary and Bruix, Jordi, additional
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- 2023
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153. Incidental finding of apical ventricular aneurysm by equilibrium isotopic ventriculography with 99mTc-NaTcO4-labeled red blood cells
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Carballo Menayo, C.M., primary, Navarro Romero, R., additional, Espinet Coll, C., additional, Bellviure-Meiro, R., additional, Roque Pérez, A., additional, Nazarena Pizzi, M., additional, and Aguadé Bruix, S., additional
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- 2023
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154. Hallazgo incidental de aneurisma ventricular apical por ventriculografía isotópica en equilibrio con hematíes marcados con 99mTc-NaTcO4
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Carballo Menayo, C.M., primary, Navarro Romero, R., additional, Espinet Coll, C., additional, Bellviure-Meiro, R., additional, Roque Pérez, A., additional, Nazarena Pizzi, M., additional, and Aguadé Bruix, S., additional
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- 2023
- Full Text
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155. Radiological endpoints as surrogates for survival benefit in hepatocellular carcinoma trials: All that glitters is not gold
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Cabibbo, Giuseppe, primary and Bruix, Jordi, additional
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- 2023
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156. Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial
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Bruix, Jordi, Takayama, Tadatoshi, Mazzaferro, Vincenzo, Chau, Gar-Yang, Yang, Jiamei, Kudo, Masatoshi, Cai, Jianqiang, Poon, Ronnie T, Han, Kwang-Hyub, Tak, Won Young, Lee, Han Chu, Song, Tianqiang, Roayaie, Sasan, Bolondi, Luigi, Lee, Kwan Sik, Makuuchi, Masatoshi, Souza, Fabricio, Berre, Marie-Aude Le, Meinhardt, Gerold, and Llovet, Josep M
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- 2015
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157. Normal Myocardial Perfusion Gated SPECT and Positive Stress Test: Different Prognoses in Women and Men
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Romero-Farina, Guillermo, Candell-Riera, Jaume, Ferreira-González, Ignacio, Aguadé-Bruix, Santiago, Pizzi, Nazarena, and García-Dorado, David
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- 2015
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158. Obtaining a formula that improves maximum oxygen consumption estimation in cycle ergometer exercise tests
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Romero-Farina, G., Candell-Riera, J., Bofill, J.M., Aguadé-Bruix, S., Pizzi, M.N., and García-Dorado, D.
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- 2015
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159. SPECT, coronary angio-CT, invasive coronary angiography and fusion images in stable coronary disease
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Pizzi, M.N., Aguadé-Bruix, S., Roque, A., Cuéllar-Calabria, H., Romero-Farina, G., García del Blanco, B., Castell-Conesa, J., García-Dorado, D., and Candell-Riera, J.
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- 2015
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160. Warranty periods for normal myocardial perfusion stress SPECT
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Romero-Farina, Guillermo, Candell-Riera, Jaume, Aguadé-Bruix, Santiago, Ferreira-González, Ignacio, Cuberas-Borrós, Gemma, Pizzi, Nazarena, and García-Dorado, David
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- 2015
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161. Update on Cardiac Imaging Techniques 2014
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Mahía-Casado, Patricia, García-Orta, Rocío, Gómez de Diego, José J., Barba-Cosials, Joaquín, Rodríguez-Palomares, José F., and Aguadé-Bruix, Santiago
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- 2015
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162. The pituitary tumour‐transforming gene 1/delta‐like homologue 1 pathway plays a key role in liver fibrogenesis
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Meritxell Perramón, Silvia Carvajal, Vedrana Reichenbach, Guillermo Fernández‐Varo, Loreto Boix, Laura Macias‐Muñoz, Pedro Melgar‐Lesmes, Jordi Bruix, Shlomo Melmed, Santiago Lamas, and Wladimiro Jiménez
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Liver Cirrhosis ,Hepatology ,Calcium-Binding Proteins ,Membrane Proteins ,Oncogenes ,Fibrosis ,Rats ,Securin ,Mice ,Liver ,Animals ,Humans ,Intercellular Signaling Peptides and Proteins ,Pituitary Neoplasms - Abstract
PTTG1 is almost undetectable in adult livers but is highly expressed in hepatocarcinoma. While little is known about its involvement in liver fibrosis, PTTG1 expression is associated with DLK1. We assessed the role of the PTTG1/DLK1 pathway in fibrosis progression and the potential therapeutic effect of PTTG1 silencing in fibrosis.Pttg1 and Dlk1 were studied in liver and isolated cell populations of control and fibrotic rats and in human liver biopsies. The fibrotic molecular signature was analysed in Pttg1Pttg1 and Dlk1 mRNA selectively increased in fibrotic rats paralleling fibrosis progression. Serum DLK1 concentrations correlated with hepatic collagen content and systemic and portal haemodynamics. Human cirrhotic livers showed greater PTTG1 and DLK1 transcript abundance than non-cirrhotic, and reduced collagen was observed in Pttg1 Pttg1Pttg1/Dlk1 are selectively overexpressed in the cirrhotic liver and participate in ECM turnover regulation. Pttg1 disruption decreases Dlk1 transcription and attenuates collagen deposition. PTTG1/DLK1 signalling is a novel pathway for targeting the progression of liver fibrosis.
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- 2022
163. Nivolumab Plus Cabozantinib With or Without Ipilimumab for Advanced Hepatocellular Carcinoma: Results From Cohort 6 of the CheckMate 040 Trial
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Yau, Thomas, primary, Zagonel, Vittorina, additional, Santoro, Armando, additional, Acosta-Rivera, Mirelis, additional, Choo, Su Pin, additional, Matilla, Ana, additional, He, Aiwu Ruth, additional, Cubillo Gracian, Antonio, additional, El-Khoueiry, Anthony B., additional, Sangro, Bruno, additional, Eldawy, Tarek E., additional, Bruix, Jordi, additional, Frassineti, Giovanni Luca, additional, Vaccaro, Gina M., additional, Tschaika, Marina, additional, Scheffold, Christian, additional, Koopmans, Petra, additional, Neely, Jaclyn, additional, and Piscaglia, Fabio, additional
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- 2022
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164. Breakthroughs in Hepatocellular Carcinoma Therapies
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Amit G. Singal, Masatoshi Kudo, and Jordi Bruix
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Hepatology ,Gastroenterology - Published
- 2023
165. Insights into insulin resistance and calcification in the Myocardium in type 2 dDiabetes: a coronary artery analysis
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Queralt Martín-Saladich, Rafael Simó, Santiago Aguadé-Bruix, Olga Simó-Servat, Carolina Aparicio-Gómez, Cristina Hernández, Clara Ramirez-Serra, María Nazarena Pizzi, Albert Roque, Miguel A. González Ballester, and José Raul Herance
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[18F]FDG-PET imaging ,Myocardium ,Organic Chemistry ,[ 18 F]FDG-PET imaging ,Metabolic disease ,Type 2 diabetes ,General Medicine ,Insulin sensibility ,Cardiovascular risk ,Coronary artery ,Catalysis ,Computer Science Applications ,Calcification ,Inorganic Chemistry ,Physical and Theoretical Chemistry ,Molecular Biology ,Computed tomography ,Spectroscopy - Abstract
Type 2 diabetes (T2D) is responsible for high incidence of cardiovascular (CV) complications leading to heart failure. Coronary artery region-specific metabolic and structural assessment could provide deeper insight into the extent of the disease and help prevent adverse cardiac events. Therefore, in this study, we aimed at investigating such myocardial dynamics for the first time in insulin-sensitive (mIS) and insulin-resistant (mIR) T2D patients. We targeted global and region-specific variations using insulin sensitivity (IS) and coronary artery calcifications (CACs) as CV risk factor in T2D patients. IS was computed using myocardial segmentation approaches at both baseline and after an hyperglycemic–insulinemic clamp (HEC) on [18F]FDG-PET images using the standardized uptake value (SUV) (ΔSUV = SUVHEC − SUVBASELINE) and calcifications using CT Calcium Scoring. Results suggest that some communicating pathways between response to insulin and calcification are present in the myocardium, whilst differences between coronary arteries were only observed in the mIS cohort. Risk indicators were mostly observed for mIR and highly calcified subjects, which supports previously stated findings that exhibit a distinguished exposure depending on the impairment of response to insulin, while projecting added potential complications due to arterial obstruction. Moreover, a pattern relating calcification and T2D phenotypes was observed suggesting the avoidance of insulin treatment in mIS but its endorsement in mIR subjects. The right coronary artery displayed more ΔSUV, whilst plaque was more present in the circumflex. However, differences between phenotypes, and therefore CV risk, were associated to left descending artery (LAD) translating into higher CACs regarding IR, which could explain why insulin treatment was effective for LAD at the expense of higher likelihood of plaque accumulation. Personalized approaches to assess T2D may lead to more efficient treatments and risk-prevention strategies.
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- 2023
166. A Pooled Multicentric Analysis of Survival in 580 Patients
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Veloso Gomes, Filipe, de Baère, Thierry, Verset, Gontran, Coimbra, Élia, Tovar-Felice, Gerardo, Malagari, Katerina, Bruix, Jordi, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
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TACE ,Hepatocellular carcinoma ,Radiology Nuclear Medicine and imaging ,Chemoembolization ,HCC survival ,Cardiology and Cardiovascular Medicine - Abstract
Funding Information: Filipe Veloso Gomes has received research grants from Terumo; educational grants from Terumo, Medtronic, Guerbet; speaker honoraria from Bayer, Guerbet, Medtronic, Roche. Thierry-de-Baere has received consulting fees from Astra-Zeneca, Boston-Scientific, Guerbet, Medtronic and Terumo. Gontran Verset has received honoraria for lectures from Terumo, BTG, Bayer. Élia Coimbra—no conflicts of interest Gerardo Tovar-Felice has received a research grant from Terumo. Katerina Malagari has received honoraria for lectures from Merit Medical, BTG, Boston Scientific, Terumo. Jordi Bruix has received consulting fees from AbbVie, Adaptimmune, Arqule, Astra-Medimmune, Basilea, Bayer-Shering Pharma, Bio-Alliance, BMS, BTG- Biocompatibles, Eisai, Gilead, Incyte, Ipsen, Kowa, Lilly, MSD, Nerviano, Novartis, Polaris, Quirem, Roche, Sirtex, Sanofi, Terumo; honararia for lectures from Bayer, Eisai, BTG/Boston Scientific, Sirtex, Terumo, Ipsen, Astra-Zeneca. Publisher Copyright: © 2023, The Author(s). Purpose: To evaluate survival, efficacy and safety of transarterial chemoembolization (TACE) in the treatment of patients with hepatocellular carcinoma (HCC), through a pooled analysis of patients with BCLC 0, A and B HCC stages, treated with polyethylene glycol drug eluting microspheres (PEG-DEM) TACE. Materials and Methods: Patients from 3 retrospective and 2 prospective registries were included. Overall survival (OS), progression-free survival (PFS), tumour response and safety were evaluated. Multivariate Cox regression analysis was performed to evaluate predictors of OS. Results: A total of 580 patients (72.1% males, mean age 66.9 ± 10.3 years) were included. 43.5% had BCLC A, and 41.0% BCLC B disease stage, and 85.8% were Child–Pugh class A. Complete and partial response (mRECIST or RECIST1.1) were achieved in 60.14% and 27.11% of patients, with overall response and disease control rates of 87.30% and 94.60%, respectively. Median OS was 50.8 months for the total population, and 61.2 and 38.1 months for BCLC 0 + A and BCLC B patients, respectively. Median PFS for the total population, BCLC 0 + A and BCLC B groups was 15.6, 21.6 and 12.7 months, respectively. Conclusions: This multicentric pooled analysis confirmed efficacy and safety of PEG-DEM TACE, with a median OS of 50.8 months. publishersversion epub_ahead_of_print
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- 2023
167. A truncated apoptin protein variant selectively kills cancer cells
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Ruiz-Martínez, Santiago, Castro, Jessica, Vilanova, Maria, Bruix, Marta, Laurents, Douglas V., Ribó, Marc, and Benito, Antoni
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- 2017
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168. 18F–FDG-PET/CT Angiography for the Diagnosis of Infective Endocarditis
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Roque, A., Pizzi, M.N., Cuéllar-Calàbria, H., and Aguadé-Bruix, S.
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- 2017
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169. HCC-neuroendocrine transition: Tumor plasticity under immunotherapy
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Marco Sanduzzi-Zamparelli, Carla Fuster-Anglada, Jordi Bruix, Maria Reig, and Alba Díaz
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Carcinoma, Hepatocellular ,Hepatology ,Liver Neoplasms ,Gastroenterology ,Humans ,Immunologic Factors ,Immunotherapy ,General Medicine - Published
- 2022
170. Methods of Quantification
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Aguadé-Bruix, Santiago, Castell-Conesa, Joan, Candell-Riera, Jaume, editor, Castell-Conesa, Joan, editor, and Aguadé-Bruix, Santiago, editor
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- 2001
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171. Radionuclides, Instrumentation and Procedures
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Ortega-Alcalde, Domingo, Aguadé-Bruix, Santiago, Candell-Riera, Jaume, editor, Castell-Conesa, Joan, editor, and Aguadé-Bruix, Santiago, editor
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- 2001
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172. Safety, Efficacy, and Pharmacodynamics of Tremelimumab Plus Durvalumab for Patients With Unresectable Hepatocellular Carcinoma: Randomized Expansion of a Phase I/II Study
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Philip He, Robin Kate Kelley, Ho Yeong Lim, Takuji Okusaka, Thomas Yau, David Wai-Meng Tai, Ghassan K. Abou-Alfa, Masafumi Ikeda, Bruno Sangro, Yoon-Koo Kang, Silvia Damian, Johanna C. Bendell, Mitesh J. Borad, William P. Harris, Tae-You Kim, Shukui Qin, Alejandra Negro, Mallory Makowsky, Nathan Standifer, Masatoshi Kudo, Ann-Lii Cheng, Jordi Bruix, Antonio Gasbarrini, and Wei Peng Yong
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Male ,0301 basic medicine ,Oncology ,Cancer Research ,Durvalumab ,0302 clinical medicine ,Monoclonal ,80 and over ,Humanized ,6.2 Cellular and gene therapies ,Cancer ,Aged, 80 and over ,Liver Disease ,Liver Neoplasms ,Middle Aged ,6.1 Pharmaceuticals ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,HIV/AIDS ,Female ,Patient Safety ,Biotechnology ,medicine.drug ,Liver Cancer ,Adult ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,medicine.drug_class ,Clinical Trials and Supportive Activities ,Clinical Sciences ,Oncology and Carcinogenesis ,Antibodies, Monoclonal, Humanized ,Monoclonal antibody ,Antibodies ,03 medical and health sciences ,Rare Diseases ,Clinical Research ,Internal medicine ,medicine ,Humans ,Oncology & Carcinogenesis ,Aged ,business.industry ,Carcinoma ,Evaluation of treatments and therapeutic interventions ,Hepatocellular ,medicine.disease ,Orphan Drug ,030104 developmental biology ,Phase i ii ,Pharmacodynamics ,Digestive Diseases ,business ,Tremelimumab - Abstract
PURPOSE This phase I/II study evaluated tremelimumab (anticytotoxic T-lymphocyte–associated antigen-4 monoclonal antibody) and durvalumab (antiprogrammed death ligand-1 monoclonal antibody) as monotherapies and in combination for patients with unresectable hepatocellular carcinoma (HCC), including a novel regimen featuring a single, priming dose of tremelimumab (ClinicalTrials.gov identifier: NCT02519348 ). PATIENTS AND METHODS Patients with HCC who had progressed on, were intolerant to, or refused sorafenib were randomly assigned to receive T300 + D (tremelimumab 300 mg plus durvalumab 1,500 mg [one dose each during the first cycle] followed by durvalumab 1,500 mg once every 4 weeks), durvalumab monotherapy (1,500 mg once every 4 weeks), tremelimumab monotherapy (750 mg once every 4 weeks [seven doses] and then once every 12 weeks), or T75 + D (tremelimumab 75 mg once every 4 weeks plus durvalumab 1,500 mg once every 4 weeks [four doses] followed by durvalumab 1,500 mg once every 4 weeks). Safety was the primary end point. Secondary end points included objective response rate (ORR) by Response Evaluation Criteria in Solid Tumors v1.1 and overall survival; exploratory end points included circulating lymphocyte profiles. RESULTS A total of 332 patients were enrolled (T300 + D, n = 75; durvalumab, n = 104; tremelimumab, n = 69; and T75 + D, n = 84). Tolerability was acceptable across arms, with grade ≥ 3 treatment-related adverse events occurring in 37.8%, 20.8%, 43.5%, and 24.4%, respectively. Confirmed ORRs (95% CI) were 24.0% (14.9 to 35.3), 10.6% (5.4 to 18.1), 7.2% (2.4 to 16.1), and 9.5% (4.2 to 17.9), respectively. An early expansion of CD8+ lymphocytes was associated with response across arms, with highest proliferating CD8+ lymphocyte levels occurring in the T300 + D arm. The median (95% CI) overall survival was 18.7 (10.8 to 27.3), 13.6 (8.7 to 17.6), 15.1 (11.3 to 20.5), and 11.3 (8.4 to 15.0) months in the T300 + D, durvalumab, tremelimumab, and T75 + D arms, respectively. CONCLUSION All regimens were found to be tolerable and clinically active; however, the T300 + D regimen demonstrated the most encouraging benefit-risk profile. The unique pharmacodynamic activity and association with ORR of the T300 + D regimen further support its continued evaluation in HCC.
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- 2021
173. Reply to responsible growth of nuclear cardiology in Spain
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Jimenez-Heffernan, Amelia, Aguadé-Bruix, Santiago, and Casans-Tormo, Irene
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- 2019
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174. 770 Safety, efficacy, and pharmacokinetic results from a phase I first-in-human study of ABBV-151 with or without anti-PD1 mAb (budigalimab) in patients with locally advanced or metastatic solid tumors
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Anthony Tolcher, Desamparados Roda-Perez, Kai He, Victor Moreno, Carlos Gomez-Roca, Jean-Pascal Machiels, Albiruni Razak, Mohammad Sahtout, Xiaowen Guan, Stacy Jaryno-Daly, Rachel Leibman, Martha Blaney, James O’Brien, Patricia Lorusso, John Powderly, Talia Golan, Kathy Miller, and Jordi Bruix
- Published
- 2022
175. Modeling the Structural and Environmental Complexity in Working Catalysts
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Albert Bruix
- Published
- 2022
176. Radiological endpoints as surrogates for survival benefit in hepatocellular carcinoma trials: All that glitters is not gold
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Giuseppe Cabibbo and Jordi Bruix
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Carcinoma, Hepatocellular ,Hepatology ,Liver Neoplasms ,Humans ,Immunotherapy ,Disease-Free Survival - Published
- 2022
177. Stability of oxidized states of freestanding and ceria-supported PtO
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Jon Eunan, Quinlivan Domínguez, Konstantin M, Neyman, and Albert, Bruix
- Abstract
Nanostructured materials based on CeO
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- 2022
178. 770 Safety, efficacy, and pharmacokinetic results from a phase I first-in-human study of ABBV-151 with or without anti-PD1 mAb (budigalimab) in patients with locally advanced or metastatic solid tumors
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Tolcher, Anthony, primary, Roda-Perez, Desamparados, additional, He, Kai, additional, Moreno, Victor, additional, Gomez-Roca, Carlos, additional, Machiels, Jean-Pascal, additional, Razak, Albiruni, additional, Sahtout, Mohammad, additional, Guan, Xiaowen, additional, Jaryno-Daly, Stacy, additional, Leibman, Rachel, additional, Blaney, Martha, additional, O’Brien, James, additional, Lorusso, Patricia, additional, Powderly, John, additional, Golan, Talia, additional, Miller, Kathy, additional, and Bruix, Jordi, additional
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- 2022
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179. Modeling the Structural and Environmental Complexity in Working Catalysts
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Bruix, Albert, primary
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- 2022
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180. Stability of oxidized states of freestanding and ceria-supported PtOx particles
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Quinlivan Domínguez, Jon Eunan, primary, Neyman, Konstantin M., additional, and Bruix, Albert, additional
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- 2022
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181. Emergence of structure through protein–protein interactions and pH changes in dually predicted coiled-coil and disordered regions of centrosomal proteins
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Treviño, Miguel A., García-Mayoral, M. Flor, Jiménez, M. Ángeles, Bastolla, Ugo, and Bruix, Marta
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- 2014
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182. Toward a Better Liver Graft Allocation That Accounts for Candidates With and Without Hepatocellular Carcinoma
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Toso, C., Mazzaferro, V., Bruix, J., Freeman, R., Mentha, G., and Majno, P.
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- 2014
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183. Systemic treatment
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Reig, Maria, Gazzola, Alessia, Di Donato, Roberto, and Bruix, Jordi
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- 2014
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184. CHAPTER 89 - Hepatocellular carcinoma
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Gomes da Fonseca, Leonardo, Ferrer-Fàbrega, Joana, and Bruix, Jordi
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- 2023
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185. Variables that influence the indication of a second myocardial perfusion gated-SPECT after a normal stress-rest gated SPECT
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Romero-Farina, G., Candell-Riera, J., Aguadé-Bruix, S., Cuberas-Borrós, G., Pizzi, M.N., Santos, A., de León, G., and García-Dorado, D.
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- 2014
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186. “Very Early” Intrahepatic Cholangiocarcinoma in Cirrhotic Patients: Should Liver Transplantation Be Reconsidered in These Patients?
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Sapisochin, G., Rodríguez de Lope, C., Gastaca, M., Ortiz de Urbina, J., Suarez, M.A., Santoyo, J., Castroagudín, J.F., Varo, E., López-Andujar, R., Palacios, F., Sanchez Antolín, G., Perez, B., Guiberteau, A., Blanco, G., González-Diéguez, M.L., Rodriguez, M., Varona, M.A., Barrera, M.A., Fundora, Y., Ferron, J.A., Ramos, E., Fabregat, J., Ciria, R., Rufian, S., Otero, A., Vazquez, M.A., Pons, J.A., Parrilla, P., Zozaya, G., Herrero, J.I., Charco, R., and Bruix, J.
- Published
- 2014
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187. Update on Cardiac Imaging Techniques 2013
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García-Orta, Rocío, Mahía-Casado, Patricia, Gómez de Diego, José J., Barba-Cosials, Joaquín, Rodriguez-Palomares, José F., Aguadé-Bruix, Santiago, and Candell-Riera, Jaume
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- 2014
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188. International and multicenter real‐world study of sorafenib‐treated patients with hepatocellular carcinoma under dialysis
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Aline Lopes Chagas, Gabriel Aballay Soteras, Margarita Sala, Adolfo Gallego, Yolanda Sánchez-Torrijos, Marcus-Alexander Wörns, Carlos Huertas, Leonardo Gomes da Fonseca, Carlos Rodríguez de Lope, Margarita Anders, M. Varela, Manuel Hernández-Guerra, Rogerio Alves, Maria Reig, Sonia Pascual, Marco Sanduzzi-Zamparelli, Tania Hernáez, Lorenza Rimassa, Mário Reis Álvares-da-Silva, Alessandro Granito, Juan Arenas, Beatriz Minguez, Cassia Leal, Ana Matilla, Jordi Bruix, Morten Ladekarl, Alberto Lué, Alex Vianey Callado França, Christie Perelló, Rodolfo Sacco, José Luis Lledó, Álvaro Díaz-González, Matthias Pinter, Juan Ignacio Marín, Gustavo Pereira, Susanna Coll, Giovan Giuseppe Di Costanzo, Massimo Iavarone, Ángela Rojas, Federico Piñero, Mercedes Vergara, Edoardo G. Giannini, Jean-Charles Nault, Mar Lozano, Bruno Sangro, Ignacio Garcia Juarez, Vivianne Mello, Josemaría Menéndez, Manuel Delgado, Diaz-Gonzalez A., Sanduzzi-Zamparelli M., da Fonseca L.G., Di Costanzo G.G., Alves R., Iavarone M., Leal C., Sacco R., Matilla A.M., Hernandez-Guerra M., Aballay Soteras G., Worns M.-A., Pinter M., Varela M., Ladekarl M., Chagas A.L., Minguez B., Arenas J.I., Granito A., Sanchez-Torrijos Y., Rojas A., Rodriguez de Lope C., Alvares-da-Silva M.R., Pascual S., Rimassa L., Lledo J.L., Huertas C., Sangro B., Giannini E.G., Delgado M., Vergara M., Perello C., Lue A., Sala M., Gallego A., Coll S., Hernaez T., Pinero F., Pereira G., Franca A., Marin J., Anders M., Mello V., Lozano M., Nault J.C., Menendez J., Garcia Juarez I., Bruix J., and Reig M.
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Niacinamide ,safety ,Sorafenib ,dialysi ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Hepatocellular carcinoma ,medicine.medical_treatment ,Population ,adverse event ,Antineoplastic Agents ,survival ,03 medical and health sciences ,0302 clinical medicine ,Renal Dialysis ,Interquartile range ,Internal medicine ,adverse events ,dialysis ,sorafenib ,medicine ,Humans ,education ,Dialysis ,Aged ,education.field_of_study ,Hepatology ,business.industry ,Phenylurea Compounds ,Liver Neoplasms ,Retrospective cohort study ,Hepatitis C ,medicine.disease ,Europe ,Treatment Outcome ,Tolerability ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,business ,medicine.drug - Abstract
Background & Aims: Information on safety and efficacy of systemic treatment in patients with hepatocellular carcinoma (HCC) under dialysis are limited due to patient exclusion from clinical trials. Thus, we aimed to evaluate the rate, prevalence, tolerability, and outcome of sorafenib in this population. Methods: We report a multicenter study comprising patients from Latin America and Europe. Patients treated with sorafenib were enrolled; demographics, dose modifications, adverse events (AEs), treatment duration, and outcome of patients undergoing dialysis were recorded. Results: As of March 2018, 6156 HCC patients were treated in 44 centres and 22 patients were concomitantly under dialysis (0.36%). The median age was 65.5years, 40.9% had hepatitis C, 75% had Child-Pugh A, and 85% were Barcelona Clinic Liver Cancer-C. The median time to first dose modification, treatment duration and overall survival rate were 2.4months (interquartile ranges [IQR], 0.8-3.8), 10.8months (IQR, 4.5-16.9), and 17.5months (95% CI, 7.2-24.5), respectively. Seventeen patients required at least 1 dose modification. The main causes of first dose modification were asthenia/worsening of Eastern Cooperative Oncology Group-Performance Status and diarrhoea. At the time of death or last follow-up, four patients were still on treatment and 18 had discontinued sorafenib: 14 were due to tumour progression, 2 were sorafenib-related, and 2 were non-sorafenib-related AE. Conclusions: The outcomes observed in this cohort seem comparable to those in the non-dialysis population. Thus, to the best of our knowledge, this is the largest and most informative dataset regarding systemic treatment outcomes in HCC patients undergoing dialysis.
- Published
- 2020
189. Phenotyping Type 2 Diabetes in Terms of Myocardial Insulin Resistance and Its Potential Cardiovascular Consequences: A New Strategy Based on 18F-FDG PET/CT
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Herance, José Raul, Simó Canonge, Rafael, Velasquez, Mayra Alejandra, Paun, Bruno, García-Leon, Daniel, Aparicio-Gómez, Carolina, Marés, Roso, Simó-Servat, Olga, Castell-Conesa, Joan, Hernández, Cristina, Aguadé-Bruix, Santiago, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Herance JR] Grup de Recerca en Imatge Mèdica Molecular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Unitat Docent de Medicina Nuclear, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERBBN, Instituto de Salud Carlos III, Madrid, Spain. [Simó R, Simó-Servat O, Hernández C] Grup de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei d’Endocrinologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain. [Velasquez MA] Grup de Recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei d’Endocrinologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Paun B, García-Leon D, Aparicio C, Marés R, Castell-Conesa J, Aguadé-Bruix S] Grup de Recerca en Imatge Mèdica Molecular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Unitat Docent de Medicina Nuclear, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus
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18 F-FDG PET/CT ,cardiovascular risk ,18F-FDG PET/CT ,enfermedades del sistema endocrino::diabetes mellitus::complicaciones de la diabetes::miocardiopatías diabéticas [ENFERMEDADES] ,Insulinoresistència ,enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus::diabetes mellitus tipo II [ENFERMEDADES] ,enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::hiperinsulinismo::resistencia a la insulina [ENFERMEDADES] ,endocrine system diseases ,Miocardi - Malalties ,Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2 [DISEASES] ,Medicine (miscellaneous) ,Type 2 diabetes ,Cardiovascular risk ,Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Cardiomyopathies [DISEASES] ,Diabetis no-insulinodependent ,Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance [DISEASES] ,Medicine ,Myocardial insulin resistance ,type 2 diabetes ,myocardial insulin resistance - Abstract
Cardiovascular risk; Myocardial insulin resistance; Type 2 diabetes Risc cardiovascular; Resistència miocàrdica a la insulina; Diabetis tipus 2 Riesgo cardiovascular; Resistencia miocárdica a la insulina; Diabetes tipo 2 Background: Systemic insulin resistance is generally postulated as an independent risk factor of cardiovascular events in type 2 diabetes (T2D). However, the role of myocardial insulin resistance (mIR) remains to be clarified. Methods: Two 18F-FDG PET/CT scans were performed on forty-three T2D patients at baseline and after hyperinsulinemic–euglycemic clamp (HEC). Myocardial insulin sensitivity (mIS) was determined by measuring the increment in myocardial 18F-FDG uptake after HEC. Coronary artery calcium scoring (CACs) and myocardial radiodensity (mRD) were assessed by CT. Results: After HEC, seventeen patients exhibited a strikingly enhancement of myocardial 18F-FDG uptake and twenty-six a marginal increase, thus revealing mIS and mIR, respectively. Patients with mIR showed higher mRD (HU: 38.95 [33.81–44.06] vs. 30.82 [21.48–38.02]; p = 0.03) and CACs > 400 (AU: 52% vs. 29%; p = 0.002) than patients with mIS. In addition, HOMA-IR and mIS only showed a correlation in those patients with mIR. Conclusions: 18F-FDG PET combined with HEC is a reliable method for identifying patients with mIR. This subgroup of patients was found to be specifically at high risk of developing cardiovascular events and showed myocardial structural changes. Moreover, the gold-standard HOMA-IR index was only associated with mIR in this subgroup of patients. Our results open up a new avenue for stratifying patients with cardiovascular risk in T2D. This research was funded by the Carlos III Health Institute and the European Regional Development Fund (PI16/02064 and PI20/01588) and AGAUR (2017SGR1303 and 2017SGR1144).
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- 2022
190. Impact of COVID-19 on the imaging diagnosis of cardiac disease in Europe
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Williams, M, Shaw, L, Hirschfeld, C, Maurovich-Horvat, P, Norgaard, B, Pontone, G, Jimenez-Heffernan, A, Sinitsyn, V, Sergienko, V, Ansheles, A, Bax, J, Buechel, R, Milan, E, Slart, R, Nicol, E, Bucciarelli-Ducci, C, Pynda, Y, Better, N, Cerci, R, Dorbala, S, Raggi, P, Villines, T, Vitola, J, Malkovskiy, E, Goebel, B, Cohen, Y, Randazzo, M, Pascual, T, Dondi, M, Paez, D, Einstein, A, Nasery, M, Goda, A, Shirka, E, Benlabgaa, R, Bouyoucef, S, Medjahedi, A, Nailli, Q, Agolti, M, Aguero, R, Del Carmen Alak, M, Alberguina, L, Arronada, G, Astesiano, A, Norton, C, Benteo, P, Blanco, J, Bonelli, J, Bustos, J, Cabrejas, R, Cachero, J, Campisi, R, Canderoli, A, Carames, S, Carrascosa, P, Castro, R, Cendoya, O, Cognigni, L, Collaud, C, Cortes, C, Courtis, J, Cragnolino, D, Daicz, M, De La Vega, A, De Maria, S, Del Riego, H, Dettori, F, Deviggiano, A, Dragonetti, L, Embon, M, Enriquez, R, Ensinas, J, Faccio, F, Facello, A, Garofalo, D, Geronazzo, R, Gonza, N, Gutierrez, L, Guzzo, M, Hasbani, V, 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M., Mor M., Muskal N., Ranser S., Shalev A., Albano D., Alongi P., Arnone G., Bagatin E., Baldari S., Bauckneht M., Bertelli P., Bianco F., Bonfiglioli R., Boni R., Bruno A., Bruno I., Busnardo E., Califaretti E., Camoni L., Carnevale A., Casoni R., Cavallo A. U., Cavenaghi G., Chierichetti F., Chiocchi M., Cittanti C., Colletta M., Conti U., Cossu A., Cuocolo A., Cuzzocrea M., De Rimini M. L., De Vincentis G., Del Giudice E., Del Torto A., Della Tommasina V., Durmo R., Erba P. A., Evangelista L., Faletti R., Faragasso E., Farsad M., Ferro P., Florimonte L., Frantellizzi V., Fringuelli F. M., Gatti M., Gaudiano A., Gimelli A., Giubbini R., Giuffrida F., Ialuna S., Laudicella R., Leccisotti L., Leva L., Liga R., Liguori C., Longo G., Maffione M., Mancini M. E., Marcassa C., Nardi B., Pacella S., Pepe G., Pulizzi S., Quartuccio N., Rampin L., Ricci F., Rossini P., Rubini G., Russo V., Sacchetti G. M., Sambuceti G., Scarano M., Sciagra R., Sperandio M., Stefanelli A., Ventroni G., Zoboli S., Baugh D., Chambers D., Madu E., Nunura F., Asano H., Chimura C. M., Fujimoto S., Fujisue K., Fukunaga T., Fukushima Y., Fukuyama K., Hashimoto J., Ichikawa Y., Iguchi N., Imai M., Inaki A., Ishimura H., Isobe S., Kadokami T., Kato T., Kudo T., Kumita S., Maruno H., Mataki H., Miyagawa M., Morimoto R., Moroi M., Nagamachi S., Nakajima K., Nakata T., Nakazato R., Nanasato M., Naya M., Norikane T., Ohta Y., Okayama S., Okizaki A., Otomi Y., Otsuka H., Saito M., Sakata S. Y., Sarai M., Sato D., Shiraishi S., Suwa Y., Takanami K., Takehana K., Taki J., Tamaki N., Taniguchi Y., Teragawa H., Tomizawa N., Tsujita K., Umeji K., Wakabayashi Y., Yamada S., Yamazaki S., Yoneyama T., Rawashdeh M., Batyrkhanov D., Dautov T., Makhdomi K., Ombati K., Alkandari F., Garashi M., Coie T. L., Rajvong S., Kalinin A., Kalnina M., Haidar M., Komiagiene R., Kviecinskiene G., Mataciunas M., Vajauskas D., Picard C., Karim N. K. A., Reichmuth L., Samuel A., Allarakha M. A., Naojee A. S., Alexanderson-Rosas E., Barragan E., Becerril A., Cabada M., Rodriguez D. C., Carvajal-Juarez I., Cortes V., Cortes F., De La Pena E., Gama-Moreno M., Gonzalez L., Ramirez N. G., Jimenez-Santos M., Matos L., Monroy E., Morelos M., Ornelas M., Ramirez J. A. O., Preciado-Anaya A., Preciado-Gutierrez O. U., Barragan A. P., Uvera S. G. R., Sandoval S., Tomas M. S., Sierra-Galan L. M., Siu S., Vallejo E., Valles M., Faraggi M., Sereegotov E., Ilic S., Ben-Rais N., Alaoui N. I., Taleb S., Myo K. P. P., Thu P. S., Ghimire R. K., Rajbanshi B., Barneveld P., Glaudemans A., Habets J., Koopmans K. P., Manders J., Pool S., Scholte A., Scholtens A., Slart R., Thimister P., Van Asperen E. -J., Veltman N., Verschure D., Wagenaar N., Edmond J., Ellis C., Johnson K., Keenan R., Kueh S. H., Occleshaw C., Sasse A., To A., Van Pelt N., Young C., Cuadra T., Vanegas H. B. R., Soli I. A., Issoufou D. M., Ayodele T., Madu C., Onimode Y., Efros-Monsen E., Forsdahl S. H., Dimmen J. -M. H., Jorgensen A., Krohn I., Lovhaugen P., Braten A. T., Al Dhuhli H., Al Kindi F., Al-Bulushi N., Jawa Z., Tag N., Afzal M. S., Fatima S., Younis M. N., Riaz M., Saadullah M., Herrera Y., Lenturut-Katal D., Vazquez M. C., Ortellado J., Akhter A., Cao D., Cheung S., Dai X., Gong L., Han D., Hou Y., Li C., Li T., Li D., Li S., Liu J., Liu H., Lu B., Ng M. Y., Sun K., Tang G., Wang J., Wang X., Wang Z. -Q., Wang Y., Wu J., Wu Z., Xia L., Xiao J., Xu L., Yang Y., Yin W., Yu J., Yuan L., Zhang T., Zhang L., Zhang Y. -G., Zhang X., Zhu L., Alfaro A., Abrihan P., Barroso A., Cruz E., Gomez M. R., Magboo V. P., Medina J. M., Obaldo J., Pastrana D., Pawhay C. M., Quinon A., Tang J. M., Tecson B., Uson K. J., Uy M., Kostkiewicz M., Kunikowska J., Bettencourt N., Cantinho G., Ferreira A., Syed G., Arnous S., Atyani S., Byrne A., Gleeson T., Kerins D., Meehan C., Murphy D., Murphy M., Murray J., O'Brien J., Bang J. -I., Bom H., Cho S. -G., Hong C. M., Jang S. J., Jeong Y. H., Kang W. J., Kim J. -Y., Namgung C. K., So Y., Won K. S., Majstorov V., Vavlukis M., Salobir B. G., Stalc M., Benedek T., Benedek I., Mititelu R., Stan C. A., Dariy O., Drozdova O., Gagarina N., Gulyaev V. M., Itskovich I., Karalkin A., Kokov A., Migunova E., Pospelov V., Ryzhkova D., Saifullina G., Sazonova S., Shurupova I., Trifonova T., Ussov W. Y., Vakhromeeva M., Valiullina N., Zavadovsky K., Zhuravlev K., Alasnag M., Okarvi S., Saranovic D. S., Keng F., See J. H. J., Sekar R., Yew M. S., Vondrak A., Bejai S., Bennie G., Bester R., Engelbrecht G., Evbuomwan O., Gongxeka H., Vuuren M. J., Kaplan M., Khushica P., Lakhi H., Louw L., Malan N., Milos K., Modiselle M., More S., Naidoo M., Scholtz L., Vangu M., Aguade-Bruix S., Blanco I., Cabrera A., Camarero A., Casans-Tormo I., Cuellar-Calabria H., Flotats A., Canamero M. E. F., Garcia M. E., Leta R., Diaz J. L., Lumbreras L., Marquez-Cabeza J. J., Martin F., De Alegria A. M., Medina F., Canal M. P., Peiro V., Pubul-Nunez V., Madrid J. I. R., Rey C. R., Perez R. R., Ruiz J., Hernandez G. S., Sevilla A., Zeidan N., Nanayakkara D., Udugama C., Simonsson M., Alkadhi H., Buechel R. R., Burger P., Ceriani L., De Boeck B., Grani C., De Saint Lager Lucas A. J., Kamani C. H., Kawel-Boehm N., Manka R., Prior J. O., Rominger A., Vallee J. -P., Khiewvan B., Premprabha T., Thientunyakit T., Sellem A., Kir K. M., Sayman H., Sebikali M. J., Muyinda Z., Kmetyuk Y., Korol P., Mykhalchenko O., Pliatsek V., Satyr M., Albalooshi B., Hassan M. I. A., Anderson J., Bedi P., Biggans T., Bularga A., Bull R., Burgul R., Carpenter J. -P., Coles D., Cusack D., Deshpande A., Dougan J., Fairbairn T., Farrugia A., Gopalan D., Gummow A., Ramkumar P. G., Hamilton M., Harbinson M., Hartley T., Hudson B., Joshi N., Kay M., Kelion A., Khokhar A., Kitt J., Low C., Mak S. M., Marousa N., Martin J., McAlindon E., Menezes L., Morgan-Hughes G., Moss A., Murray A., Patel D., Peebles C., Pugliese F., Rodrigues J. C. L., Rofe C., Sabharwal N., Schofield R., Semple T., Sharma N., Strouhal P., Subedi D., Topping W., Tweed K., Weir-Mccall J., Abbara S., Abbasi T., Abbott B., Abohashem S., Abramson S., Al-Abboud T., Al-Mallah M., Almousalli O., Ananthasubramaniam K., Kumar M. A., Askew J., Attanasio L., Balmer-Swain M., Bayer R. R., Bernheim A., Bhatti S., Bieging E., Blankstein R., Bloom S., Blue S., Bluemke D., Borges A., Branch K., Bravo P., Brothers J., Budoff M., Bullock-Palmer R., Burandt A., Burke F. 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E., McKenna M., McRae T., Mendoza F., Merhige M., Min D., Moffitt C., Moncher K., Moore W., Morayati S., Morris M., Mossa-Basha M., Mrsic Z., Murthy V., Nagpal P., Napier K., Narula J., Nelson K., Nijjar P., Osman M., Parwani P., Passen E., Patel A., Patil P., Paul R., Phillips L., Polsani V., Poludasu R., Pomerantz B., Porter T., Prentice R., Pursnani A., Rabbat M., Ramamurti S., Rich F., Luna H. R., Robinson A., Robles K., Rodriguez C., Rorie M., Rumberger J., Russell R., Sabra P., Sadler D., Schemmer M., Schoepf U. J., Shah S., Shah N., Shanbhag S., Sharma G., Shayani S., Shirani J., Shivaram P., Sigman S., Simon M., Slim A., Smith D., Smith A., Soman P., Srichai-Parsia M. B., Streeter J., Albert T., Tawakol A., Thomas D., Thompson R., Torbet T., Trinidad D., Ullery S., Unzek S., Uretsky S., Vallurupalli S., Verma V., Waller A., Wang E., Ward P., Weissman G., Wesbey G., White K., Winchester D., Wolinsky D., Yost S., Zgaljardic M., Alonso O., Beretta M., Ferrando R., Kapitan M., Mut F., Djuraev O., Rozikhodjaeva G., Ngoc H. L., Mai S. H., and Nguyen X. C.
- Abstract
Objectives We aimed to explore the impact of the COVID-19 pandemic on cardiac diagnostic testing and practice and to assess its impact in different regions in Europe. Methods The online survey organised by the International Atomic Energy Agency Division of Human Health collected information on changes in cardiac imaging procedural volumes between March 2019 and March/April 2020. Data were collected from 909 centres in 108 countries. Results Centres in Northern and Southern Europe were more likely to cancel all outpatient activities compared with Western and Eastern Europe. There was a greater reduction in total procedure volumes in Europe compared with the rest of the world in March 2020 (45% vs 41%, p=0.003), with a more marked reduction in Southern Europe (58%), but by April 2020 this was similar in Europe and the rest of the world (69% vs 63%, p=0.261). Regional variations were apparent between imaging modalities, but the largest reductions were in Southern Europe for nearly all modalities. In March 2020, location in Southern Europe was the only independent predictor of the reduction in procedure volume. However, in April 2020, lower gross domestic product and higher COVID-19 deaths were the only independent predictors. Conclusion The first wave of the COVID-19 pandemic had a significant impact on care of patients with cardiac disease, with substantial regional variations in Europe. This has potential long-term implications for patients and plans are required to enable the diagnosis of non-COVID- 19 conditions during the ongoing pandemic.
- Published
- 2021
191. Impact of COVID-19 Pandemic on Cardiovascular Testing in Asia
- Author
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Franca, Chiocchi, Marcello, Cittanti, Corrado, Colletta, Mauro, Conti, Umberto, Cossu, Alberto, Cuocolo, Alberto, Cuzzocrea, Marco, De Rimini, Maria Luisa, De Vincentis, Giuseppe, Del Giudice, Eleonora, Del Torto, Alberico, Della Tommasina, Veronica, Durmo, Rexhep, Erba, Paola Anna, Evangelista, Laura, Faletti, Riccardo, Faragasso, Evelina, Farsad, Mohsen, Ferro, Paola, Florimonte, Luigia, Frantellizzi, Viviana, Fringuelli, Fabio Massimo, Gatti, Marco, Gaudiano, Angela, Gimelli, Alessia, Giubbini, Raffaele, Giuffrida, Francesca, Ialuna, Salvatore, Laudicella, Riccardo, Leccisotti, Lucia, Leva, Lucia, Liga, Riccardo, Liguori, Carlo, Longo, Giampiero, Maffione, Margherita, Mancini, Maria Elisabetta, Marcassa, Claudio, Milan, Elisa, Nardi, Barbara, Pacella, Sara, Pepe, Giovanna, Pontone, Gianluca, Pulizzi, Sabina, Quartuccio, Natale, Rampin, Lucia, Ricci, Fabrizio, Rossini, Pierluigi, Rubini, Giuseppe, Russo, Vincenzo, Sacchetti, Gian Mauro, Sambuceti, Gianmario, Scarano, Massimo, Sciagrà, Roberto, Sperandio, Massimiliano, Stefanelli, Antonella, Ventroni, Guido, Zoboli, Stefania, Baugh, Dainia, Chambers, Duane, Madu, Ernest, Nunura, Felix, Asano, Hiroshi, Chimura, Chimura Misato, Fujimoto, Shinichiro, Fujisue, Koichiro, Fukunaga, Tomohisa, Fukushima, Yoshimitsu, Fukuyama, Kae, Hashimoto, Jun, Ichikawa, Yasutaka, Iguchi, Nobuo, Imai, Masamichi, Inaki, Anri, Ishimura, Hayato, Isobe, Satoshi, Kadokami, Toshiaki, Kato, Takao, Kumita, Shinichiro, Maruno, Hirotaka, Mataki, Hiroyuki, Miyagawa, Masao, Morimoto, Ryota, Moroi, Masao, Nagamachi, Shigeki, Nakajima, Kenichi, Nakata, Tomoaki, Nakazato, Ryo, Nanasato, Mamoru, Naya, Masanao, Norikane, Takashi, Ohta, Yasutoshi, Okayama, Satoshi, Okizaki, Atsutaka, Otomi, Yoichi, Otsuka, Hideki, Saito, Masaki, Sakata, Sakata Yasushi, Sarai, Masayoshi, Sato, Daisuke, Shiraishi, Shinya, Suwa, Yoshinobu, Takanami, Kentaro, Takehana, Kazuya, Taki, Junichi, Tamaki, Nagara, Taniguchi, Yasuyo, Teragawa, Hiroki, Tomizawa, Nobuo, Tsujita, Kenichi, Umeji, Kyoko, Wakabayashi, Yasushi, Yamada, Shinichiro, Yamazaki, Shinya, Yoneyama, Tatsuya, Rawashdeh, Mohammad, Batyrkhanov, Daultai, Makhdomi, Khalid, Ombati, Kevin, Alkandari, Faridah, Garashi, Masoud, Coie, Tchoyoson Lim, Rajvong, Sonexay, Kalinin, Artem, Kalnina, Marika, Haidar, Mohamad, Komiagiene, Renata, Kviecinskiene, Giedre, Mataciunas, Mindaugas, Vajauskas, Donatas, Picard, Christian, Karim, Noor Khairiah A., Reichmuth, Luise, Samuel, Anthony, Allarakha, Mohammad Aaftaab, Naojee, Ambedhkar Shantaram, Alexanderson-Rosas, Erick, Barragan, Erika, González-Montecinos, Alejandro Becerril, Cabada, Manuel, Rodriguez, Daniel Calderon, Carvajal-Juarez, Isabel, Cortés, Violeta, Cortés, Filiberto, De La Peña, Erasmo, Gama-Moreno, Manlio, González, Luis, Ramírez, Nelsy Gonzalez, Jiménez-Santos, Moisés, Matos, Luis, Monroy, Edgar, Morelos, Martha, Ornelas, Mario, Ortga Ramirez, Jose Alberto, Preciado-Anaya, Andrés, Preciado-Gutiérrez, Óscar Ulises, Barragan, Adriana Puente, Rosales Uvera, Sandra Graciela, Sandoval, Sigelinda, Tomas, Miguel Santaularia, Sierra-Galan, Lilia M., Siu, Silvia, Vallejo, Enrique, Valles, Mario, Faraggi, Marc, Sereegotov, Erdenechimeg, Ilic, Srdja, Ben-Rais, Nozha, Alaoui, Nadia Ismaili, Taleb, Sara, Pa Myo, Khin Pa, Thu, Phyo Si, Ghimire, Ram Kumar, Rajbanshi, Bijoy, Barneveld, Peter, Glaudemans, Andor, Habets, Jesse, Koopmans, Klaas Pieter, Manders, Jeroen, Pool, Stefan, Scholte, Arthur, Scholtens, Asbjørn, Slart, Riemer, Thimister, Paul, Van Asperen, Erik-Jan, Veltman, Niels, Verschure, Derk, Wagenaar, Nils, Edmond, John, Ellis, Chris, Johnson, Kerryanne, Keenan, Ross, Kueh, Shaw Hua (Anthony), Occleshaw, Christopher, Sasse, Alexander, To, Andrew, Van Pelt, Niels, Young, Calum, Cuadra, Teresa, Roque Vanegas, Hector Bladimir, Soli, Idrissa Adamou, Issoufou, Djibrillou Moussa, Ayodele, Tolulope, Madu, Chibuzo, Onimode, Yetunde, Efros-Monsen, Elen, Forsdahl, Signe Helene, Hildre Dimmen, Jenni-Mari, Jørgensen, Arve, Krohn, Isabel, Løvhaugen, Pål, Bråten, Anders Tjellaug, Al Dhuhli, Humoud, Al Kindi, Faiza, Al-Bulushi, Naeema, Jawa, Zabah, Tag, Naima, Afzal, Muhammad Shehzad, Fatima, Shazia, Younis, Muhammad Numair, Riaz, Musab, Saadullah, Mohammad, Herrera, Yariela, Lenturut-Katal, Dora, Vázquez, Manuel Castillo, Ortellado, José, Akhter, Afroza, Cao, Dianbo, Cheung, Stephen, Dai, Xu, Gong, Lianggeng, Han, Dan, Hou, Yang, Li, Caiying, Li, Tao, Li, Dong, Li, Sijin, Liu, Jinkang, Liu, Hui, Ng, Ming Yen, Sun, Kai, Tang, Gongshun, Wang, Jian, Wang, Ximing, Wang, Zhao-Qian, Wang, Yining, Wang, Yifan, Wu, Jiang, Wu, Zhifang, Xia, Liming, Xiao, Jiangxi, Xu, Lei, Yang, Youyou, Yin, Wu, Yu, Jianqun, Yuan, Li, Zhang, Tong, Zhang, Longjiang, Zhang, Yong-Gao, Zhang, Xiaoli, Zhu, Li, Alfaro, Ana, Abrihan, Paz, Barroso, Asela, Cruz, Eric, Gomez, Marie Rhiamar, Magboo, Vincent Peter, Medina, John Michael, Obaldo, Jerry, Pastrana, Davidson, Pawhay, Christian Michael, Quinon, Alvin, Tang, Jeanelle Margareth, Tecson, Bettina, Uson, Kristine Joy, Uy, Mila, Kostkiewicz, Magdalena, Kunikowska, Jolanta, Bettencourt, Nuno, Cantinho, Guilhermina, Ferreira, Antonio, Syed, Ghulam, Arnous, Samer, Atyani, Said, Byrne, Angela, Gleeson, Tadhg, Kerins, David, Meehan, Conor, Murphy, David, Murphy, Mark, Murray, John, O'Brien, Julie, Bang, Ji-In, Bom, Henry, Cho, Sang-Geon, Hong, Chae Moon, Jang, Su Jin, Jeong, Yong Hyu, Kang, Won Jun, Kim, Ji-Young, Lee, Jaetae, Namgung, Chang Kyeong, So, Young, Won, Kyoung Sook, Majstorov, Venjamin, Vavlukis, Marija, Salobir, Barbara Gužic, Štalc, Monika, Benedek, Theodora, Benedek, Imre, Mititelu, Raluca, Stan, Claudiu Adrian, Ansheles, Alexey, Dariy, Olga, Drozdova, Olga, Gagarina, Nina, Gulyaev, Vsevolod Milyevich, Itskovich, Irina, Karalkin, Anatoly, Kokov, Alexander, Migunova, Ekaterina, Pospelov, Viktor, Ryzhkova, Daria, Saifullina, Guzaliya, Sazonova, Svetlana, Sergienko, Vladimir, Shurupova, Irina, Trifonova, Tatjana, Ussov, Wladimir Yurievich, Vakhromeeva, Margarita, Valiullina, Nailya, Zavadovsky, Konstantin, Zhuravlev, Kirill, Okarvi, Subhani, Saranovic, Dragana Sobic, Keng, Felix, Jason See, Jia Hao, Sekar, Ramkumar, Yew, Min Sen, Vondrak, Andrej, Bejai, Shereen, Bennie, George, Bester, Ria, Engelbrecht, Gerrit, Evbuomwan, Osayande, Gongxeka, Harlem, Vuuren, Magritha Jv, Kaplan, Mitchell, Khushica, Purbhoo, Lakhi, Hoosen, Louw, Lizette, Malan, Nico, Milos, Katarina, Modiselle, Moshe, More, Stuart, Naidoo, Mathava, Scholtz, Leonie, Vangu, Mboyo, Aguadé-Bruix, Santiago, Blanco, Isabel, Cabrera, Antonio, Camarero, Alicia, Casáns-Tormo, Irene, Cuellar-Calabria, Hug, Flotats, Albert, Fuentes Cañamero, Maria Eugenia, García, María Elia, Jimenez-Heffernan, Amelia, Leta, Rubén, Diaz, Javier Lopez, Lumbreras, Luis, Marquez-Cabeza, Juan Javier, Martin, Francisco, Martinez de Alegria, Anxo, Medina, Francisco, Canal, Maria Pedrera, Peiro, Virginia, Pubul-Nuñez, Virginia, Rayo Madrid, Juan Ignacio, Rey, Cristina Rodríguez, Perez, Ricardo Ruano, Ruiz, Joaquín, Hernández, Gertrudis Sabatel, Sevilla, Ana, Zeidán, Nahla, Nanayakkara, Damayanthi, Udugama, Chandraguptha, Simonsson, Magnus, Alkadhi, Hatem, Buechel, Ronny Ralf, Burger, Peter, Ceriani, Luca, De Boeck, Bart, Gräni, Christoph, Juillet de Saint Lager Lucas, Alix, Kamani, Christel H., Kawel-Boehm, Nadine, Manka, Robert, Prior, John O., Rominger, Axel, Vallée, Jean-Paul, Khiewvan, Benjapa, Premprabha, Teerapon, Thientunyakit, Tanyaluck, Sellem, Ali, Kir, Kemal Metin, Sayman, Haluk, Sebikali, Mugisha Julius, Muyinda, Zerida, Kmetyuk, Yaroslav, Korol, Pavlo, Mykhalchenko, Olena, Pliatsek, Volodymyr, Satyr, Maryna, Albalooshi, Batool, Ahmed Hassan, Mohamed Ismail, Anderson, Jill, Bedi, Punit, Biggans, Thomas, Bularga, Anda, Bull, Russell, Burgul, Rajesh, Carpenter, John-Paul, Coles, Duncan, Cusack, David, Deshpande, Aparna, Dougan, John, Fairbairn, Timothy, Farrugia, Alexia, Gopalan, Deepa, Gummow, Alistair, Ramkumar, Prasad Guntur, Hamilton, Mark, Harbinson, Mark, Hartley, Thomas, Hudson, Benjamin, Joshi, Nikhil, Kay, Michael, Kelion, Andrew, Khokhar, Azhar, Kitt, Jamie, Lee, Ken, Low, Chen, Mak, Sze Mun, Marousa, Ntouskou, Martin, Jon, Mcalindon, Elisa, Menezes, Leon, Morgan-Hughes, Gareth, Moss, Alastair, Murray, Anthony, Nicol, Edward, Patel, Dilip, Peebles, Charles, Pugliese, Francesca, Luis Rodrigues, Jonathan Carl, Rofe, Christopher, Sabharwal, Nikant, Schofield, Rebecca, Semple, Thomas, Sharma, Naveen, Strouhal, Peter, Subedi, Deepak, Topping, William, Tweed, Katharine, Weir-Mccall, Jonathan, Abbara, Suhny, Abbasi, Taimur, Abbott, Brian, Abohashem, Shady, Abramson, Sandra, Al-Abboud, Tarek, Al-Mallah, Mouaz, Almousalli, Omar, Ananthasubramaniam, Karthikeyan, Kumar, Mohan Ashok, Askew, Jeffrey, Attanasio, Lea, Balmer-Swain, Mallory, Bayer, Richard R., Bernheim, Adam, Bhatti, Sabha, Bieging, Erik, Blankstein, Ron, Bloom, Stephen, Blue, Sean, Bluemke, David, Borges, Andressa, Branch, Kelley, Bravo, Paco, Brothers, Jessica, Budoff, Matthew, Bullock-Palmer, Renée, Burandt, Angela, Burke, Floyd W., Bush, Kelvin, Candela, Candace, Capasso, Elizabeth, Cavalcante, Joao, Chang, Donald, Chatterjee, Saurav, Chatzizisis, Yiannis, Cheezum, Michael, Chen, Tiffany, Chen, Jennifer, Chen, Marcus, Clarcq, James, Cordero, Ayreen, Crim, Matthew, Danciu, Sorin, Decter, Bruce, Dhruva, Nimish, Doherty, Neil, Doukky, Rami, Dunbar, Anjori, Duvall, William, Edwards, Rachael, Esquitin, Kerry, Farah, Husam, Fentanes, Emilio, Ferencik, Maros, Fisher, Daniel, Fitzpatrick, Daniel, Foster, Cameron, Fuisz, Tony, Gannon, Michael, Gastner, Lori, Gerson, Myron, Ghoshhajra, Brian, Goldberg, Alan, Goldner, Brian, Gonzalez, Jorge, Gore, Rosco, Gracia-López, Sandra, Hage, Fadi, Haider, Agha, Haider, Sofia, Hamirani, Yasmin, Hassen, Karen, Hatfield, Mallory, Hawkins, Carolyn, Hawthorne, Katie, Heath, Nicholas, Hendel, Robert, Hernandez, Phillip, Hill, Gregory, Horgan, Stephen, Huffman, Jeff, Hurwitz, Lynne, Iskandrian, Ami, Janardhanan, Rajesh, Jellis, Christine, Jerome, Scott, Kalra, Dinesh, Kaviratne, Summanther, Kay, Fernando, Kelly, Faith, Khalique, Omar, Kinkhabwala, Mona, Iii, George Kinzfogl, Kircher, Jacqueline, Kirkbride, Rachael, Kontos, Michael, Kottam, Anupama, Krepp, Joseph, Layer, Jay, Lee, Steven H., Leppo, Jeffrey, Lesser, John, Leung, Steve, Lewin, Howard, Litmanovich, Diana, Liu, Yiyan, Magurany, Kathleen, Markowitz, Jeremy, Marn, Amanda, Matis, Stephen E., Mckenna, Michael, Mcrae, Tony, Mendoza, Fernando, Merhige, Michael, Min, David, Moffitt, Chanan, Moncher, Karen, Moore, Warren, Morayati, Shamil, Morris, Michael, Mossa-Basha, Mahmud, Mrsic, Zorana, Murthy, Venkatesh, Nagpal, Prashant, Napier, Kyle, Nelson, Katarina, Nijjar, Prabhjot, Osman, Medhat, Passen, Edward, Patel, Amit, Patil, Pravin, Paul, Ryan, Phillips, Lawrence, Polsani, Venkateshwar, Poludasu, Rajaram, Pomerantz, Brian, Porter, Thomas, Prentice, Ryan, Pursnani, Amit, Rabbat, Mark, Ramamurti, Suresh, Rich, Florence, Luna, Hiram Rivera, Robinson, Austin, Robles, Kim, Rodríguez, Cesar, Rorie, Mark, Rumberger, John, Russell, Raymond, Sabra, Philip, Sadler, Diego, Schemmer, Mary, Schoepf, U. Joseph, Shah, Samir, Shah, Nishant, Shanbhag, Sujata, Sharma, Gaurav, Shayani, Steven, Shirani, Jamshid, Shivaram, Pushpa, Sigman, Steven, Simon, Mitch, Slim, Ahmad, Smith, David, Smith, Alexandra, Soman, Prem, Sood, Aditya, Srichai-Parsia, Monvadi Barbara, Streeter, James, T, Albert, Tawakol, Ahmed, Thomas, Dustin, Thompson, Randall, Torbet, Tara, Trinidad, Desiree, Ullery, Shawn, Unzek, Samuel, Uretsky, Seth, Vallurupalli, Srikanth, Verma, Vikas, Waller, Alfonso, Wang, Ellen, Ward, Parker, Weissman, Gaby, Wesbey, George, White, Kelly, Winchester, David, Wolinsky, David, Yost, Sandra, Zgaljardic, Michael, Alonso, Omar, Beretta, Mario, Ferrando, Rodolfo, Kapitan, Miguel, Mut, Fernando, Djuraev, Omoa, Rozikhodjaeva, Gulnora, Le Ngoc, Ha, Mai, Son Hong, Nguyen, Xuan Canh, Kudo, T, Lahey, R, Hirschfeld, C, Williams, M, Lu, B, Alasnag, M, Bhatia, M, Henry Bom, H, Dautov, T, Fazel, R, Karthikeyan, G, Keng, F, Rubinshtein, R, Better, N, Cerci, R, Dorbala, S, Raggi, P, Shaw, L, Villines, T, 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Patel, Shivani, Saxena, Sudhir, Sengupta, Shantanu, Singh, Santosh, Singh, Bhanupriya, Sood, Ashwani, Verma, Atul, Affandi, Erwin, Alam, Padma Savenadia, Edison, Edison, Gunawan, Gani, Hapkido, Habusari, Hidayat, Basuki, Huda, Aulia, Mukti, Anggoro Praja, Prawiro, Djoko, Soeriadi, Erwin Affandi, Syawaluddin, Hilman, Albadr, Amjed, Assadi, Majid, Emami, Farshad, Houshmand, Golnaz, Maleki, Majid, Rostami, Maryam Tajik, Zakavi, Seyed Rasoul, Zaid, Eed Abu, Agranovich, Svetlana, Arnson, Yoav, Bar-Shalom, Rachel, Frenkel, Alex, Knafo, Galit, Lugassi, Rachel, Maor Moalem, Israel Shlomo, Mor, Maya, Muskal, Noam, Ranser, Sara, Shalev, Aryeh, Albano, Domenico, Alongi, Pierpaolo, Arnone, Gaspare, Bagatin, Elisa, Baldari, Sergio, Bauckneht, Matteo, Bertelli, Paolo, Bianco, Francesco, Bonfiglioli, Rachele, Boni, Roberto, Bruno, Andrea, Bruno, Isabella, Busnardo, Elena, Califaretti, Elena, Camoni, Luca, Carnevale, Aldo, Casoni, Roberta, Cavallo, Armando Ugo, Cavenaghi, Giorgio, Chierichetti, Franca, Chiocchi, Marcello, Cittanti, Corrado, Colletta, Mauro, Conti, Umberto, Cossu, Alberto, Cuocolo, Alberto, Cuzzocrea, Marco, De Rimini, Maria Luisa, De Vincentis, Giuseppe, Del Giudice, Eleonora, Del Torto, Alberico, Della Tommasina, Veronica, Durmo, Rexhep, Erba, Paola Anna, Evangelista, Laura, Faletti, Riccardo, Faragasso, Evelina, Farsad, Mohsen, Ferro, Paola, Florimonte, Luigia, Frantellizzi, Viviana, Fringuelli, Fabio Massimo, Gatti, Marco, Gaudiano, Angela, Gimelli, Alessia, Giubbini, Raffaele, Giuffrida, Francesca, Ialuna, Salvatore, Laudicella, Riccardo, Leccisotti, Lucia, Leva, Lucia, Liga, Riccardo, Liguori, Carlo, Longo, Giampiero, Maffione, Margherita, Mancini, Maria Elisabetta, Marcassa, Claudio, Milan, Elisa, Nardi, Barbara, Pacella, Sara, Pepe, Giovanna, Pontone, Gianluca, Pulizzi, Sabina, Quartuccio, Natale, Rampin, Lucia, Ricci, Fabrizio, Rossini, Pierluigi, Rubini, Giuseppe, Russo, Vincenzo, Sacchetti, Gian Mauro, Sambuceti, Gianmario, Scarano, Massimo, Sciagrà, Roberto, Sperandio, Massimiliano, Stefanelli, Antonella, Ventroni, Guido, Zoboli, Stefania, Baugh, Dainia, Chambers, Duane, Madu, Ernest, Nunura, Felix, Asano, Hiroshi, Chimura, Chimura Misato, Fujimoto, Shinichiro, Fujisue, Koichiro, Fukunaga, Tomohisa, Fukushima, Yoshimitsu, Fukuyama, Kae, Hashimoto, Jun, Ichikawa, Yasutaka, Iguchi, Nobuo, Imai, Masamichi, Inaki, Anri, Ishimura, Hayato, Isobe, Satoshi, Kadokami, Toshiaki, Kato, Takao, Kumita, Shinichiro, Maruno, Hirotaka, Mataki, Hiroyuki, Miyagawa, Masao, Morimoto, Ryota, Moroi, Masao, Nagamachi, Shigeki, Nakajima, Kenichi, Nakata, Tomoaki, Nakazato, Ryo, Nanasato, Mamoru, Naya, Masanao, Norikane, Takashi, Ohta, Yasutoshi, Okayama, Satoshi, Okizaki, Atsutaka, Otomi, Yoichi, Otsuka, Hideki, Saito, Masaki, Sakata, Sakata Yasushi, Sarai, Masayoshi, Sato, Daisuke, Shiraishi, Shinya, Suwa, Yoshinobu, Takanami, Kentaro, Takehana, Kazuya, Taki, Junichi, Tamaki, Nagara, Taniguchi, Yasuyo, Teragawa, Hiroki, Tomizawa, Nobuo, Tsujita, Kenichi, Umeji, Kyoko, Wakabayashi, Yasushi, Yamada, Shinichiro, Yamazaki, Shinya, Yoneyama, Tatsuya, Rawashdeh, Mohammad, Batyrkhanov, Daultai, Makhdomi, Khalid, Ombati, Kevin, Alkandari, Faridah, Garashi, Masoud, Coie, Tchoyoson Lim, Rajvong, Sonexay, Kalinin, Artem, Kalnina, Marika, Haidar, Mohamad, Komiagiene, Renata, Kviecinskiene, Giedre, Mataciunas, Mindaugas, Vajauskas, Donatas, Picard, Christian, Karim, Noor Khairiah A., Reichmuth, Luise, Samuel, Anthony, Allarakha, Mohammad Aaftaab, Naojee, Ambedhkar Shantaram, Alexanderson-Rosas, Erick, Barragan, Erika, González-Montecinos, Alejandro Becerril, Cabada, Manuel, Rodriguez, Daniel Calderon, Carvajal-Juarez, Isabel, Cortés, Violeta, Cortés, Filiberto, De La Peña, Erasmo, Gama-Moreno, Manlio, González, Luis, Ramírez, Nelsy Gonzalez, Jiménez-Santos, Moisés, Matos, Luis, Monroy, Edgar, Morelos, Martha, Ornelas, Mario, Ortga Ramirez, Jose Alberto, Preciado-Anaya, Andrés, Preciado-Gutiérrez, Óscar Ulises, Barragan, Adriana Puente, Rosales Uvera, Sandra Graciela, Sandoval, Sigelinda, Tomas, Miguel Santaularia, Sierra-Galan, Lilia M., Siu, Silvia, Vallejo, Enrique, Valles, Mario, Faraggi, Marc, Sereegotov, Erdenechimeg, Ilic, Srdja, Ben-Rais, Nozha, Alaoui, Nadia Ismaili, Taleb, Sara, Pa Myo, Khin Pa, Thu, Phyo Si, Ghimire, Ram Kumar, Rajbanshi, Bijoy, Barneveld, Peter, Glaudemans, Andor, Habets, Jesse, Koopmans, Klaas Pieter, Manders, Jeroen, Pool, Stefan, Scholte, Arthur, Scholtens, Asbjørn, Slart, Riemer, Thimister, Paul, Van Asperen, Erik-Jan, Veltman, Niels, Verschure, Derk, Wagenaar, Nils, Edmond, John, Ellis, Chris, Johnson, Kerryanne, Keenan, Ross, Kueh, Shaw Hua (Anthony), Occleshaw, Christopher, Sasse, Alexander, To, Andrew, Van Pelt, Niels, Young, Calum, Cuadra, Teresa, Roque Vanegas, Hector Bladimir, Soli, Idrissa Adamou, Issoufou, Djibrillou Moussa, Ayodele, Tolulope, Madu, Chibuzo, Onimode, Yetunde, Efros-Monsen, Elen, Forsdahl, Signe Helene, Hildre Dimmen, Jenni-Mari, Jørgensen, Arve, Krohn, Isabel, Løvhaugen, Pål, Bråten, Anders Tjellaug, Al Dhuhli, Humoud, Al Kindi, Faiza, Al-Bulushi, Naeema, Jawa, Zabah, Tag, Naima, Afzal, Muhammad Shehzad, Fatima, Shazia, Younis, Muhammad Numair, Riaz, Musab, Saadullah, Mohammad, Herrera, Yariela, Lenturut-Katal, Dora, Vázquez, Manuel Castillo, Ortellado, José, Akhter, Afroza, Cao, Dianbo, Cheung, Stephen, Dai, Xu, Gong, Lianggeng, Han, Dan, Hou, Yang, Li, Caiying, Li, Tao, Li, Dong, Li, Sijin, Liu, Jinkang, Liu, Hui, Ng, Ming Yen, Sun, Kai, Tang, Gongshun, Wang, Jian, Wang, Ximing, Wang, Zhao-Qian, Wang, Yining, Wang, Yifan, Wu, Jiang, Wu, Zhifang, Xia, Liming, Xiao, Jiangxi, Xu, Lei, Yang, Youyou, Yin, Wu, Yu, Jianqun, Yuan, Li, Zhang, Tong, Zhang, Longjiang, Zhang, Yong-Gao, Zhang, Xiaoli, Zhu, Li, Alfaro, Ana, Abrihan, Paz, Barroso, Asela, Cruz, Eric, Gomez, Marie Rhiamar, Magboo, Vincent Peter, Medina, John Michael, Obaldo, Jerry, Pastrana, Davidson, Pawhay, Christian Michael, Quinon, Alvin, Tang, Jeanelle Margareth, Tecson, Bettina, Uson, Kristine Joy, Uy, Mila, Kostkiewicz, Magdalena, Kunikowska, Jolanta, Bettencourt, Nuno, Cantinho, Guilhermina, Ferreira, Antonio, Syed, Ghulam, Arnous, Samer, Atyani, Said, Byrne, Angela, Gleeson, Tadhg, Kerins, David, Meehan, Conor, Murphy, David, Murphy, Mark, Murray, John, O'Brien, Julie, Bang, Ji-In, Bom, Henry, Cho, Sang-Geon, Hong, Chae Moon, Jang, Su Jin, Jeong, Yong Hyu, Kang, Won Jun, Kim, Ji-Young, Lee, Jaetae, Namgung, Chang Kyeong, So, Young, Won, Kyoung Sook, Majstorov, Venjamin, Vavlukis, Marija, Salobir, Barbara Gužic, Štalc, Monika, Benedek, Theodora, Benedek, Imre, Mititelu, Raluca, Stan, Claudiu Adrian, Ansheles, Alexey, Dariy, Olga, Drozdova, Olga, Gagarina, Nina, Gulyaev, Vsevolod Milyevich, Itskovich, Irina, Karalkin, Anatoly, Kokov, Alexander, Migunova, Ekaterina, Pospelov, Viktor, Ryzhkova, Daria, Saifullina, Guzaliya, Sazonova, Svetlana, Sergienko, Vladimir, Shurupova, Irina, Trifonova, Tatjana, Ussov, Wladimir Yurievich, Vakhromeeva, Margarita, Valiullina, Nailya, Zavadovsky, Konstantin, Zhuravlev, Kirill, Okarvi, Subhani, Saranovic, Dragana Sobic, Keng, Felix, Jason See, Jia Hao, Sekar, Ramkumar, Yew, Min Sen, Vondrak, Andrej, Bejai, Shereen, Bennie, George, Bester, Ria, Engelbrecht, Gerrit, Evbuomwan, Osayande, Gongxeka, Harlem, Vuuren, Magritha Jv, Kaplan, Mitchell, Khushica, Purbhoo, Lakhi, Hoosen, Louw, Lizette, Malan, Nico, Milos, Katarina, Modiselle, Moshe, More, Stuart, Naidoo, Mathava, Scholtz, Leonie, Vangu, Mboyo, Aguadé-Bruix, Santiago, Blanco, Isabel, Cabrera, Antonio, Camarero, Alicia, Casáns-Tormo, Irene, Cuellar-Calabria, Hug, Flotats, Albert, Fuentes Cañamero, Maria Eugenia, García, María Elia, Jimenez-Heffernan, Amelia, Leta, Rubén, Diaz, Javier Lopez, Lumbreras, Luis, Marquez-Cabeza, Juan Javier, Martin, Francisco, Martinez de Alegria, Anxo, Medina, Francisco, Canal, Maria Pedrera, Peiro, Virginia, Pubul-Nuñez, Virginia, Rayo Madrid, Juan Ignacio, Rey, Cristina Rodríguez, Perez, Ricardo Ruano, Ruiz, Joaquín, Hernández, Gertrudis Sabatel, Sevilla, Ana, Zeidán, Nahla, Nanayakkara, Damayanthi, Udugama, Chandraguptha, Simonsson, Magnus, Alkadhi, Hatem, Buechel, Ronny Ralf, Burger, Peter, Ceriani, Luca, De Boeck, Bart, Gräni, Christoph, Juillet de Saint Lager Lucas, Alix, Kamani, Christel H., Kawel-Boehm, Nadine, Manka, Robert, Prior, John O., Rominger, Axel, Vallée, Jean-Paul, Khiewvan, Benjapa, Premprabha, Teerapon, Thientunyakit, Tanyaluck, Sellem, Ali, Kir, Kemal Metin, Sayman, Haluk, Sebikali, Mugisha Julius, Muyinda, Zerida, Kmetyuk, Yaroslav, Korol, Pavlo, Mykhalchenko, Olena, Pliatsek, Volodymyr, Satyr, Maryna, Albalooshi, Batool, Ahmed Hassan, Mohamed Ismail, Anderson, Jill, Bedi, Punit, Biggans, Thomas, Bularga, Anda, Bull, Russell, Burgul, Rajesh, Carpenter, John-Paul, Coles, Duncan, Cusack, David, Deshpande, Aparna, Dougan, John, Fairbairn, Timothy, Farrugia, Alexia, Gopalan, Deepa, Gummow, Alistair, Ramkumar, Prasad Guntur, Hamilton, Mark, Harbinson, Mark, Hartley, Thomas, Hudson, Benjamin, Joshi, Nikhil, Kay, Michael, Kelion, Andrew, Khokhar, Azhar, Kitt, Jamie, Lee, Ken, Low, Chen, Mak, Sze Mun, Marousa, Ntouskou, Martin, Jon, Mcalindon, Elisa, Menezes, Leon, Morgan-Hughes, Gareth, Moss, Alastair, Murray, Anthony, Nicol, Edward, Patel, Dilip, Peebles, Charles, Pugliese, Francesca, Luis Rodrigues, Jonathan Carl, Rofe, Christopher, Sabharwal, Nikant, Schofield, Rebecca, Semple, Thomas, Sharma, Naveen, Strouhal, Peter, Subedi, Deepak, Topping, William, Tweed, Katharine, Weir-Mccall, Jonathan, Abbara, Suhny, Abbasi, Taimur, Abbott, Brian, Abohashem, Shady, Abramson, Sandra, Al-Abboud, Tarek, Al-Mallah, Mouaz, Almousalli, Omar, Ananthasubramaniam, Karthikeyan, Kumar, Mohan Ashok, Askew, Jeffrey, Attanasio, Lea, Balmer-Swain, Mallory, Bayer, Richard R., Bernheim, Adam, Bhatti, Sabha, Bieging, Erik, Blankstein, Ron, Bloom, Stephen, Blue, Sean, Bluemke, David, Borges, Andressa, Branch, Kelley, Bravo, Paco, Brothers, Jessica, Budoff, Matthew, Bullock-Palmer, Renée, Burandt, Angela, Burke, Floyd W., Bush, Kelvin, Candela, Candace, Capasso, Elizabeth, Cavalcante, Joao, Chang, Donald, Chatterjee, Saurav, Chatzizisis, Yiannis, Cheezum, Michael, Chen, Tiffany, Chen, Jennifer, Chen, Marcus, Clarcq, James, Cordero, Ayreen, Crim, Matthew, Danciu, Sorin, Decter, Bruce, Dhruva, Nimish, Doherty, Neil, Doukky, Rami, Dunbar, Anjori, Duvall, William, Edwards, Rachael, Esquitin, Kerry, Farah, Husam, Fentanes, Emilio, Ferencik, Maros, Fisher, Daniel, Fitzpatrick, Daniel, Foster, Cameron, Fuisz, Tony, Gannon, Michael, Gastner, Lori, Gerson, Myron, Ghoshhajra, Brian, Goldberg, Alan, Goldner, Brian, Gonzalez, Jorge, Gore, Rosco, Gracia-López, Sandra, Hage, Fadi, Haider, Agha, Haider, Sofia, Hamirani, Yasmin, Hassen, Karen, Hatfield, Mallory, Hawkins, Carolyn, Hawthorne, Katie, Heath, Nicholas, Hendel, Robert, Hernandez, Phillip, Hill, Gregory, Horgan, Stephen, Huffman, Jeff, Hurwitz, Lynne, Iskandrian, Ami, Janardhanan, Rajesh, Jellis, Christine, Jerome, Scott, Kalra, Dinesh, Kaviratne, Summanther, Kay, Fernando, Kelly, Faith, Khalique, Omar, Kinkhabwala, Mona, Iii, George Kinzfogl, Kircher, Jacqueline, Kirkbride, Rachael, Kontos, Michael, Kottam, Anupama, Krepp, Joseph, Layer, Jay, Lee, Steven H., Leppo, Jeffrey, Lesser, John, Leung, Steve, Lewin, Howard, Litmanovich, Diana, Liu, Yiyan, Magurany, Kathleen, Markowitz, Jeremy, Marn, Amanda, Matis, Stephen E., Mckenna, Michael, Mcrae, Tony, Mendoza, Fernando, Merhige, Michael, Min, David, Moffitt, Chanan, Moncher, Karen, Moore, Warren, Morayati, Shamil, Morris, Michael, Mossa-Basha, Mahmud, Mrsic, Zorana, Murthy, Venkatesh, Nagpal, Prashant, Napier, Kyle, Nelson, Katarina, Nijjar, Prabhjot, Osman, Medhat, Passen, Edward, Patel, Amit, Patil, Pravin, Paul, Ryan, Phillips, Lawrence, Polsani, Venkateshwar, Poludasu, Rajaram, Pomerantz, Brian, Porter, Thomas, Prentice, Ryan, Pursnani, Amit, Rabbat, Mark, Ramamurti, Suresh, Rich, Florence, Luna, Hiram Rivera, Robinson, Austin, Robles, Kim, Rodríguez, Cesar, Rorie, Mark, Rumberger, John, Russell, Raymond, Sabra, Philip, Sadler, Diego, Schemmer, Mary, Schoepf, U. Joseph, Shah, Samir, Shah, Nishant, Shanbhag, Sujata, Sharma, Gaurav, Shayani, Steven, Shirani, Jamshid, Shivaram, Pushpa, Sigman, Steven, Simon, Mitch, Slim, Ahmad, Smith, David, Smith, Alexandra, Soman, Prem, Sood, Aditya, Srichai-Parsia, Monvadi Barbara, Streeter, James, T, Albert, Tawakol, Ahmed, Thomas, Dustin, Thompson, Randall, Torbet, Tara, Trinidad, Desiree, Ullery, Shawn, Unzek, Samuel, Uretsky, Seth, Vallurupalli, Srikanth, Verma, Vikas, Waller, Alfonso, Wang, Ellen, Ward, Parker, Weissman, Gaby, Wesbey, George, White, Kelly, Winchester, David, Wolinsky, David, Yost, Sandra, Zgaljardic, Michael, Alonso, Omar, Beretta, Mario, Ferrando, Rodolfo, Kapitan, Miguel, Mut, Fernando, Djuraev, Omoa, Rozikhodjaeva, Gulnora, Le Ngoc, Ha, Mai, Son Hong, and Nguyen, Xuan Canh
- Abstract
Background: The coronavirus disease-2019 (COVID-19) pandemic significantly affected management of cardiovascular disease around the world. The effect of the pandemic on volume of cardiovascular diagnostic procedures is not known. Objectives: This study sought to evaluate the effects of the early phase of the COVID-19 pandemic on cardiovascular diagnostic procedures and safety practices in Asia. Methods: The International Atomic Energy Agency conducted a worldwide survey to assess changes in cardiovascular procedure volume and safety practices caused by COVID-19. Testing volumes were reported for March 2020 and April 2020 and were compared to those from March 2019. Data from 180 centers across 33 Asian countries were grouped into 4 subregions for comparison. Results: Procedure volumes decreased by 47% from March 2019 to March 2020, showing recovery from March 2020 to April 2020 in Eastern Asia, particularly in China. The majority of centers cancelled outpatient activities and increased time per study. Practice changes included implementing physical distancing and restricting visitors. Although COVID testing was not commonly performed, it was conducted in one-third of facilities in Eastern Asia. The most severe reductions in procedure volumes were observed in lower-income countries, where volumes decreased 81% from March 2019 to April 2020. Conclusions: The COVID-19 pandemic in Asia caused significant reductions in cardiovascular diagnostic procedures, particularly in low-income countries. Further studies on effects of COVID-19 on cardiovascular outcomes and changes in care delivery are warranted.
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- 2021
192. Pilot study of living donor liver transplantation for patients with hepatocellular carcinoma exceeding Milan Criteria (Barcelona Clinic Liver Cancer extended criteria)
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Llovet, Josep M., Pavel, Mihai, Rimola, Jordi, Diaz, Maria Alba, Colmenero, Jordi, Saavedra-Perez, David, Fondevila, Constantino, Ayuso, Carmen, Fuster, Josep, Ginès, Pere, Bruix, Jordi, and Garcia-Valdecasas, Juan Carlos
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- 2018
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193. Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma
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Gerbes, Alexander, Zoulim, Fabien, Tilg, Herbert, Dufour, Jean-François, Bruix, Jordi, Paradis, Valérie, Salem, Riad, Peck-Radosavljevic, Markus, Galle, Peter R, Greten, Tim F, Nault, Jean-Charles, and Avila, Matias A
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- 2018
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194. Complete response under sorafenib in patients with hepatocellular carcinoma: Relationship with dermatologic adverse events
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Rimola, Jordi, Díaz‐González, Álvaro, Darnell, Anna, Varela, María, Pons, Fernando, Hernandez‐Guerra, Manuel, Delgado, Manuel, Castroagudin, Javier, Matilla, Ana, Sangro, Bruno, Rodriguez de Lope, Carlos, Sala, Margarita, Gonzalez, Carmen, Huertas, Carlos, Minguez, Beatriz, Ayuso, Carmen, Bruix, Jordi, and Reig, María
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- 2018
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195. Liver Imaging Reporting and Data System: Review of Pros and Cons
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Eleonora Terzi, Carmen Ayuso, Fabio Piscaglia, and Jordi Bruix
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medicine.medical_specialty ,Carcinoma, Hepatocellular ,Contrast Media ,Malignancy ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,In patient ,Retrospective Studies ,Liver imaging ,Hepatology ,medicine.diagnostic_test ,business.industry ,Liver Neoplasms ,cons ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,digestive system diseases ,Review article ,Hepatocellular carcinoma ,030211 gastroenterology & hepatology ,Radiology ,business ,Contrast-enhanced ultrasound - Abstract
The American College of Radiology has released the Liver Imaging Reporting and Data System (LI-RADS) scheme which categorizes focal liver lesions (FLLs) in patients at risk for hepatocellular carcinoma (HCC) according to the degree of risk of nodules to be HCC. It subgroups FLL in LR-1 (definitely benign), LR-2 (probably benign), LR-3 (intermediate probability of malignancy), LR-4 (probably HCC), LR-5 (definitely HCC), and LR-M (probable malignancy not specific for HCC). Computed tomography/magnetic resonance imaging (CT/MRI) and contrast enhanced ultrasound (CEUS) LI-RADS diagnostic algorithm have the goal to standardize the acquisition, interpretation, reporting, and data collection for imaging examinations in patients at risk for HCC. Nevertheless, there remain controversial issues that should be dealt with. The aim of this review is to discuss the pros and cons of the interpretation and reporting part of CT/MRI and CEUS LI-RADS diagnostic algorithm to permit future refinements of the scheme and optimize patient and nodule management.
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- 2021
196. Effect of Regorafenib in Delaying Definitive Deterioration in Health-Related Quality of Life in Patients with Advanced Cancer of Three Different Tumor Types
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Dawn Odom, George D. Demetri, Marisca Marian, Axel Grothey, Ralf-Dieter Hofheinz, Jennifer Bartsch, and Jordi Bruix
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Oncology ,medicine.medical_specialty ,Colorectal cancer ,gastrointestinal cancer ,Placebo ,chemistry.chemical_compound ,Quality of life ,Internal medicine ,Regorafenib ,Medicine ,Gastrointestinal cancer ,Stromal tumor ,Original Research ,GiST ,business.industry ,Proportional hazards model ,metastatic colorectal cancer ,medicine.disease ,digestive system diseases ,hepatocellular cancer ,quality of life ,chemistry ,Cancer Management and Research ,regorafenib ,business - Abstract
Ralf-Dieter Hofheinz,1 Jordi Bruix,2 George D Demetri,3 Axel Grothey,4 Marisca Marian,5 Jennifer Bartsch,6 Dawn Odom6 1Interdisciplinary Tumor Center, University of Heidelberg, Mannheim, Germany; 2Barcelona Clinic Liver Cancer (BCLC) Group, Hospital Clinic. IDIBAPS, University of Barcelona, CIBERehd, Barcelona, Spain; 3Ludwig Center, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; 4Gastrointestinal Cancer Research, West Cancer Center, OneOncology, Germantown, TN, USA; 5Oncology, Pharmaceuticals Division of Bayer AG, Basel, Switzerland; 6Department of Biostatistics, RTI Health Solutions, Research Triangle Park, NC, USACorrespondence: Ralf-Dieter HofheinzInterdisciplinary Tumor Center, University of Heidelberg, Theodor-Kutzer Ufer 1-3, Mannheim, 68167, GermanyTel +49 621 383 2855Fax +49 621 383 2488Email ralf.hofheinz@umm.dePurpose: The efficacy and safety of regorafenib have been demonstrated in phase 3 trials for multiple tumor types, including metastatic colorectal cancer (mCRC) (CORRECT [NCT01103323]; CONCUR [NCT01584830]), advanced gastrointestinal stromal tumor (GIST) (GRID [NCT01271712]), and hepatocellular carcinoma (HCC) (RESORCE [NCT01774344]). The objective of this post hoc exploratory analysis was to explore the impact of regorafenib on delaying health-related quality of life (HRQOL) deterioration across these tumor types.Patients and Methods: HRQOL data (assessed with EORTC QLQ-C30 and EQ-5D questionnaires) were pooled for all trials to determine time until definitive deterioration (TUDD), defined as the patientâs first minimal clinically important deterioration in HRQOL score from baseline that does not resolve, using stratified KaplanâMeier estimators and Cox proportional hazards models adjusted for relevant trial, cancer type, and baseline covariates. Additional analyses based on cancer type were conducted by pooling mCRC trials (CORRECT and CONCUR) and pooling the two mCRC trials with the HCC trial (RESORCE).Results: A total of 1699 patients with HRQOL data were pooled across the four trials. The results showed that regorafenib significantly delayed TUDD compared with placebo across all three tumor types. Median time to deterioration across the five scales ranged from 16.3 to 24.1 weeks for regorafenib and 8.6 to 12.1 weeks for placebo. The results from the individual studies, the pooled mCRC trials, and the pooled mCRC and HCC trials were similar to the overall pooled results.Conclusion: A pooled analysis of four phase 3 trials demonstrated that regorafenib delayed a clinically relevant exploratory endpoint, defined as TUDD, compared with placebo across three different tumor types (mCRC, GIST, and HCC), which supports a novel benefit of the impact of regorafenib with respect to patients with these three types of cancers by allowing initial declines in HRQOL to resolve and patients the opportunity to continue treatment.Keywords: gastrointestinal cancer, metastatic colorectal cancer, hepatocellular cancer, quality of life, regorafenib
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- 2021
197. Early diarrhoea under sorafenib as a marker to consider the early migration to second‐line drugs
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Marco Sanduzzi-Zamparelli, Loreto Boix, Maria Reig, Alejandro Forner, Carmen Ayuso, Gemma Iserte, Victor Sapena, Ernest Belmonte, Sergio Muñoz-Martínez, Cassia Guedes, Anna Darnell, Ferran Torres, Jordi Bruix, Leonardo G Da Fonseca, Jordi Rimola, Neus Llarch, and Álvaro Díaz-González
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Male ,Cancer cells ,Time Factors ,Gastroenterology ,Tyrosine-kinase inhibitor ,Proteïna-tirosina-fosfatasa ,tyrosine kinase inhibitor ,Second line ,Protein kinases ,Survival analysis (Biometry) ,Protein-tyrosine phosphatase ,Inhibition ,Liver Neoplasms ,digestive, oral, and skin physiology ,Hazard ratio ,hepatocellular carcinoma ,Middle Aged ,Sorafenib ,Prognosis ,Survival Rate ,Treatment Outcome ,Oncology ,Hepatocellular carcinoma ,Cèl·lules canceroses ,Female ,Original Article ,Liver cancer ,medicine.drug ,Diarrhea ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Bevacizumab ,medicine.drug_class ,Antineoplastic Agents ,survival ,Càncer de fetge ,resistance ,Anàlisi de supervivència (Biometria) ,Atezolizumab ,Internal medicine ,medicine ,Humans ,Adverse effect ,Protein Kinase Inhibitors ,neoplasms ,Resistència als medicaments ,Aged ,Proportional Hazards Models ,Hepatology ,business.industry ,medicine.disease ,Hepatologia ,Proteïnes quinases ,diarrhoea ,Inhibició ,Drug Resistance, Neoplasm ,Drug resistance ,Hepatobiliary ,Diarrea ,business - Abstract
Background Despite atezolizumab and bevacizumab (A + B) is currently the first‐line treatment for hepatocellular carcinoma (HCC) patients, some patients will not be adequate for this combination. In the setting of sorafenib some adverse events have been proposed as prognostic factors. Objective To characterize the early diarrhoea development as prognostic factor in 344 HCC patients. Methods The development of early diarrhoea in sorafenib treatment defined as patients who developed diarrhoea and needed dose modification within the first 60 days of treatment (e‐diarrhoea) and 3‐grouping variables were analysed: Patients with e‐diarrhoea, patients who developed diarrhoea after the first 60 days of treatment (L‐diarrhoea) and patients that never developed diarrhoea (never diarrhoea). Results The median overall survival in sorafenib treated patients was significantly different across groups (6.8 months for e‐diarrhoea, 26.7 months for L‐diarrhoea and 13.3 months for never‐diarrhoea). The emergence of e‐diarrhoea was associated with poor outcomes (hazard ratio [HR] 1.84 [95%CI 1.15–2.95]), while there was no increased/decreased risk of dismal evolution in patients with L‐diarrhoea (HR 0.66 [95%CI 0.42–1.03]). Conclusion The emergence of e‐diarrhoea in HCC patients treated with sorafenib is an early predictor of dismal evolution under this therapy. Thus, prompt identification of these non‐responders may be useful for an early switch to second‐line therapies., Key Summary Established knowledge on this subject Diarrhoea is a frequent adverse event of sorafenib and its emergence has been associated to better outcomes. What are the significant and/or new findings of this study? Early diarrhoea (e‐diarrhoea) in hepatocellular carcinoma patients treated with sorafenib is an early predictor of dismal evolution.Diarrhoea under sorafenib should not be taken as a predictive parameter of lack of benefit.E‐diarrhoea could be used as clinical biomarker for switching to second‐line therapies.
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- 2021
198. Endpoints in clinical trials for liver cancer and their value in evidence-based clinical decision making: An unresolved Gordian knot
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Jordi Bruix
- Subjects
0301 basic medicine ,Value (ethics) ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Evidence-based practice ,Clinical Decision-Making ,Antineoplastic Agents ,03 medical and health sciences ,Clinical Trials, Phase II as Topic ,0302 clinical medicine ,Clinical decision making ,medicine ,Humans ,Treatment Failure ,Precision Medicine ,Intensive care medicine ,Hepatology ,business.industry ,Liver Neoplasms ,Cancer ,Evidence-based medicine ,medicine.disease ,Progression-Free Survival ,Clinical trial ,030104 developmental biology ,Precision oncology ,Disease Progression ,030211 gastroenterology & hepatology ,Immunotherapy ,Liver cancer ,business - Abstract
Summary The design and execution of clinical trials relies on strict definitions and criteria to avoid heterogeneous decisions by investigators at different sites. Ideally, definitions and decision making in clinical practice should mimic those implemented in trials, but this is not the case. Target populations are narrowly defined in trials, with the goal of evaluating activity and toxicity, and ultimately, demonstrating a survival benefit. In real-world practice, patients may not fit into the stringent inclusion/exclusion criteria of clinical trials. The evaluation of activity may also differ and the common policy to stop therapy upon progression may not be followed if progression is minor. Indeed, registration of progression may not reflect treatment failure or resistance. Parameters such as response according to RECIST criteria, time to progression and progression-free survival are not fully informative and cannot be assumed as a definitive surrogate for survival, which is the hardest endpoint in therapeutic cancer studies. This difference is because of the varying methods used to evaluate drug activity and tumour evolution, which ultimately dictates patient outcome. This expert opinion exposes the current discrepancies between research trials and clinical practice. Understanding the origin and limitations of such a conundrum should be the first step in refining the criteria that define drug activity, toxicity and treatment failure. Otherwise, evidence-based clinical practice and precision oncology will be an unattainable reality.
- Published
- 2021
199. Hepatocellular carcinoma
- Author
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Liccioni, Alexandre, primary, Reig, Maria E., additional, and Bruix, Jordi, additional
- Published
- 2017
- Full Text
- View/download PDF
200. Contributors
- Author
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Abou-Alfa, Ghassan K., primary, Abou Khalil, Jad, additional, Addeo, Pietro, additional, Adsay, N. Volkan, additional, Agarwal, Anil Kumar, additional, Alemi, Farzad, additional, Allen, Peter J., additional, Al-Mukhtar, Ahmed, additional, Aloia, Thomas A., additional, Andersen, Jesper B., additional, Anderson, Christopher D., additional, Arslan-Carlon, Vittoria, additional, Asbun, Horacio J., additional, Aussilhou, Béatrice, additional, Awad, Joseph, additional, Azoulay, Daniel, additional, Bachellier, Philippe, additional, Baker, Talia B., additional, Bamboat, Zubin M., additional, Barkun, Jeffrey Stewart, additional, Bassi, Claudio, additional, Basturk, Olca, additional, Beard, Rachel E., additional, Bedossa, Pierre, additional, Belghiti, Jacques, additional, Bellorin-Marin, Omar, additional, Besselink, Marc G.H., additional, Bilchik, Anton J., additional, Blumgart, Leslie H., additional, Boas, Franz Edward, additional, Brody, Lynn A., additional, Brown, Karen T., additional, Bruix, Jordi, additional, Bruno, David A., additional, Brunt, Elizabeth M., additional, Burns, Justin M., additional, Butturini, Giovanni, additional, Caicedo, Juan Carlos, additional, Callery, Mark P., additional, Calvino, Abdul Saied, additional, Carpenter, Danielle H., additional, Carter, C. Ross, additional, Cauchy, François, additional, Chan, Chung Yip, additional, Chan, See Ching, additional, Chapman, William C., additional, Cherqui, Daniel, additional, Cho, Clifford S., additional, Chung, Jin Wook, additional, Clanton, Jesse, additional, Clary, Bryan Marshall, additional, Cleary, Sean Patrick, additional, Collins, Kelly M., additional, Conneely, John Barry, additional, Connell, Louise C., additional, Corvera, Carlos U., additional, Costa, Guido, additional, Covey, Anne M., additional, Crippin, Jeffrey S., additional, Croome, Kristopher P., additional, Dabbous, Hany, additional, D'Angelica, Michael I., additional, Darcy, Michael D., additional, Davis, Jeremy L., additional, de Jonge, Jeroen, additional, DeMatteo, Ronald P., additional, DePeralta, Danielle K., additional, Desai, Niraj M., additional, de Santibañes, Eduardo, additional, de Santibañes, Martin, additional, Dickson, Euan J., additional, DiMaio, Christopher John, additional, Do, Richard Kinh Gian, additional, Dokmak, Safi, additional, Donati, Marcello, additional, Doyle, M.B. Majella, additional, Dudeja, Vikas, additional, Dunphy, Mark, additional, Earl, Truman M., additional, Ebata, Tomoki, additional, Dika, Imane El, additional, El-Gohary, Yousef, additional, Endo, Itaru, additional, Enestvedt, C. Kristian, additional, Espat, N. Joseph, additional, Ethun, Cecilia G., additional, Fan, Sheung Tat, additional, Fanta, Paul T., additional, Farges, Olivier, additional, Ferrone, Cristina R., additional, Fields, Ryan C., additional, Fischer, Mary, additional, Fisher, Sarah B., additional, Flaherty, Devin C., additional, Fong, Yuman, additional, Friedman, Scott L., additional, Gabr, Ahmed, additional, Galloway, John R., additional, Geller, David A., additional, Gerdes, Hans, additional, Gerst, Scott R., additional, Gittes, George K., additional, Glorioso, Jaime, additional, Gluskin, Jill S., additional, Goh, Brian K.P., additional, Gonzalez, Stevan A., additional, Goodman, Karyn A., additional, Gores, Gregory J., additional, Gotuzzo, Eduardo H., additional, Gouma, Dirk J., additional, Greig, Paul D., additional, Griffin, James F., additional, Halloran, Christopher M., additional, Halpern, Neil A., additional, Hammill, Chet W., additional, Hansen, Paul D., additional, Harding, James J., additional, M. Harrison, Ewen, additional, Hartwig, Werner, additional, Hasegawa, Kiyoshi, additional, Hechtman, Jaclyn F., additional, Heimbach, Julie K., additional, Helton, William S., additional, Hemming, Alan W., additional, Henderson, J. Michael, additional, Hirshberg, Asher, additional, Howe, James R., additional, Hughes, Christopher B., additional, Iacobuzio-Donahue, Christine, additional, Jarnagin, William R., additional, Jenkins, Roger L., additional, Jutric, Zeljka, additional, Kahlert, Christoph, additional, Kallini, Joseph Ralph, additional, Kangrga, Ivan, additional, Karanicolas, Paul J., additional, Katz, Seth S., additional, Katz, Steven C., additional, Kelly, Kaitlyn J., additional, Kemeny, Nancy E., additional, Kennedy, Eugene P., additional, Khalili, Korosh, additional, Khan, Adeel S., additional, Khan, Saboor, additional, Kim, Heung Bae, additional, Kingham, T. Peter, additional, Kirk, Allan D., additional, S. Klimstra, David, additional, Kluger, Michael, additional, Knechtle, Stuart J., additional, Koea, Jonathan B., additional, Kokudo, Norihiro, additional, Koliogiannis, Dionysios, additional, Kooby, David A., additional, Korenblat, Kevin, additional, Krebs, Simone, additional, LaQuaglia, Michael J., additional, LaQuaglia, Michael P., additional, LaRusso, Nicholas F., additional, Laurent, Alexis, additional, Lazaridis, Konstantinos N., additional, Leal, Julie N., additional, Lee, Eliza J., additional, Lee, Major Kenneth, additional, Lee, Ser Yee, additional, Lencioni, Riccardo, additional, Liccioni, Alexandre, additional, Lidsky, Michael E., additional, Lin, Chung-Wei, additional, Linehan, David C., additional, Lopez-Solis, Roberto Carlos, additional, Lowell, Jeffrey A., additional, Madoff, David C., additional, Maggi, Jason, additional, Maithel, Shishir K., additional, Majeed, Ali W., additional, Malfertheiner, Peter, additional, Malleo, Giuseppe, additional, Mao, Shennen A., additional, Marchegiani, Giovanni, additional, Marcos, Luis A., additional, Markmann, James F., additional, Marsh, J. Wallis, additional, Martin, Robert C.G., additional, Matsuyama, Ryusei, additional, Matter, Matthias S., additional, Mattera, Francisco Juan, additional, Maxwell, Jessica E., additional, Mazza, Oscar M., additional, McGilvray, Ian D., additional, McKay, Colin J., additional, McWeeney, Doireann M., additional, Melendez, Jose, additional, Mendelsohn, Robin B., additional, Miller, George, additional, Mönkemüller, Klaus E., additional, Mori, Ryutaro, additional, Moutinho, Vitor, additional, Nagino, Masato, additional, Nagorney, David M., additional, Nagula, Satish, additional, Nakeeb, Attila, additional, Nedredal, Geir I., additional, Neoptolemos, John P., additional, Neuberger, James, additional, Nyberg, Scott L., additional, O'Connor, Rachel, additional, O'Grady, John G., additional, Oldfield, Frances E., additional, Oldhafer, Karl J., additional, Olthoff, Kim M., additional, Orloff, Susan L., additional, Paniccia, Alessandro, additional, Paradis, Valérie, additional, Parks, Rowan W., additional, Pascal, Gérard, additional, Pastores, Stephen M., additional, Pawlik, Timothy M., additional, Pillarisetty, Venu G., additional, Pingpank, James Francis, additional, Pinson, C. Wright, additional, Pitt, Henry Anthony, additional, Pomposelli, James J., additional, Procopio, Fabio, additional, Pucci, Michael J., additional, Qadan, Motaz, additional, Rajkomar, Kheman, additional, Reddy, Srinevas K., additional, Reig, Maria E., additional, Reza, Joseph Arturo, additional, Roberts, John Paul, additional, Robson, Piera Marie Cote, additional, Rocha, Flavio G., additional, Roll, Garrett Richard, additional, Ronnekleiv-Kelly, Sean M., additional, Rosemurgy, Alexander S., additional, Rosen, Charles B., additional, Saldinger, Pierre F., additional, Salem, Riad, additional, Salem, Suhail Bakr, additional, Salvia, Roberto, additional, Sandroussi, Charbel, additional, Sanford, Dominic E., additional, Scatton, Olivier, additional, Schattner, Mark Andrew, additional, Schecter, William Palmer, additional, Schoellhammer, Hans Francis, additional, Schulick, Richard D., additional, Schwartz, Lawrence H., additional, Shah, Kevin N., additional, Shepherd, Ross W., additional, Shimada, Hiroshi, additional, Shimoda, Masafumi, additional, Shindoh, Junichi, additional, Shokouh-Amiri, Hosein, additional, Sicklick, Jason K., additional, Siegelbaum, Robert H., additional, Singh, Gagandeep, additional, Smoot, Rory L., additional, Solomon, Stephen B., additional, Soubrane, Olivier, additional, Spinelli, Nicholas, additional, Stauffer, John A., additional, Stewart, Lygia, additional, Strand, Matthew S., additional, Tabibian, James H., additional, Torzilli, Guido, additional, Trotter, James F., additional, Turcotte, Simon, additional, Turmelle, Yumirle P., additional, Tzimas, Demetrios J., additional, Van Gulik, Thomas, additional, Vannucci, Andrea, additional, Vauthey, Jean-Nicolas, additional, Vetter, Diana, additional, Vilgrain, Valérie, additional, Villamil, Alejandra Maria, additional, Voigt, Louis P., additional, Vollmer, Charles M., additional, Wands, Jack R., additional, Wattacheril, Julia, additional, Weber, Sharon Marie, additional, Weiss, Matthew J., additional, Weitz, Jürgen, additional, Werner, Jens, additional, Winner, Megan, additional, Wong, John, additional, Yang, Dennis, additional, Yarmohammadi, Hooman, additional, Yeo, Charles J., additional, Yeo, Theresa Pluth, additional, Yoon, Chang Jin, additional, Yopp, Adam, additional, Young, D. Owen, additional, Zhao, Kai, additional, Zibari, Gazi B., additional, and Zogopoulos, George, additional
- Published
- 2017
- Full Text
- View/download PDF
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