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153. Tutorial: Sign Language Linguistics

Author

Bross, Fabian, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Özgün, Aybüke, editor, and Zinova, Yulia, editor

Published
2022
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155. A new aberrantly spliced BCR‐ABL1 transcript variant (e13a1) identified in routine monitoring using different quantitative reverse transcription polymerase chain reaction techniques in a patient with chronic myeloid leukemia

Author

Nicole Naumann, Ulrike Bross‐Bach, Wolfgang Seifarth, Alice Fabarius, Wolf‐Karsten Hofmann, Susanne Saußele, and Birgit Spiess

Subjects
BCR‐ABL1, CML, qRT‐PCR, rare transcript, splice variant, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Abstract Quantitative reverse transcription polymerase chain reaction (qRT‐PCR) of BCR‐ABL1 transcript level is an essential part of routine disease monitoring in patients with chronic myeloid leukemia. One patient sample (e13a2 transcript detected by nested PCR) attracted attention by revealing an aberrantly spliced BCR‐ABL1 transcript variant e13a1. The last 38 base pairs (bp) of BCR exon 13 were replaced by a 37 bp insertion of the ABL1 intron 1–2/exon 1 sequence. The rare aberrant BCR‐ABL1 fusion transcript can cause discrepancies in molecular diagnostics. This scenario highlights the importance of an individual characterization of the BCR‐ABL1 fusion sequence in case of unclear qRT‐PCR results.

Published
2022
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156. Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network

Author

A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, A. Aduszkiewicz, J. Aguilar, Z. Ahmad, J. Ahmed, B. Aimard, B. Ali-Mohammadzadeh, T. Alion, K. Allison, S. Alonso Monsalve, M. AlRashed, C. Alt, A. Alton, R. Alvarez, P. Amedo, J. Anderson, C. Andreopoulos, M. Andreotti, M. Andrews, F. Andrianala, S. Andringa, N. Anfimov, A. Ankowski, M. Antoniassi, M. Antonova, A. Antoshkin, S. Antusch, A. Aranda-Fernandez, L. Arellano, L. O. Arnold, M. A. Arroyave, J. Asaadi, L. Asquith, A. Aurisano, V. Aushev, D. Autiero, V. Ayala Lara, M. Ayala-Torres, F. Azfar, M. Babicz, A. Back, H. Back, J. J. Back, C. Backhouse, I. Bagaturia, L. Bagby, N. Balashov, S. Balasubramanian, P. Baldi, B. Baller, B. Bambah, F. Barao, G. Barenboim, G. Barker, W. Barkhouse, C. Barnes, G. Barr, J. Barranco Monarca, A. Barros, N. Barros, J. L. Barrow, A. Basharina-Freshville, A. Bashyal, V. Basque, C. Batchelor, E. Batista das Chagas, J. Battat, F. Battisti, F. Bay, M. C. Q. Bazetto, J. Bazo Alba, J. F. Beacom, E. Bechetoille, B. Behera, C. Beigbeder, L. Bellantoni, G. Bellettini, V. Bellini, O. Beltramello, N. Benekos, C. Benitez Montiel, F. Bento Neves, J. Berger, S. Berkman, P. Bernardini, R. M. Berner, A. Bersani, S. Bertolucci, M. Betancourt, A. Betancur Rodríguez, A. Bevan, Y. Bezawada, T. S. Bezerra, A. Bhardwaj, V. Bhatnagar, M. Bhattacharjee, D. Bhattarai, S. Bhuller, B. Bhuyan, S. Biagi, J. Bian, M. Biassoni, K. Biery, B. Bilki, M. Bishai, A. Bitadze, A. Blake, F. Blaszczyk, G. Blazey, E. Blucher, J. Boissevain, S. Bolognesi, T. Bolton, L. Bomben, M. Bonesini, M. Bongrand, C. Bonilla-Diaz, F. Bonini, A. Booth, F. Boran, S. Bordoni, A. Borkum, N. Bostan, P. Bour, C. Bourgeois, D. Boyden, J. Bracinik, D. Braga, D. Brailsford, A. Branca, A. Brandt, J. Bremer, D. Breton, C. Brew, S. J. Brice, C. Brizzolari, C. Bromberg, J. Brooke, A. Bross, G. Brunetti, M. Brunetti, N. Buchanan, H. Budd, I. Butorov, I. Cagnoli, T. Cai, D. Caiulo, R. Calabrese, P. Calafiura, J. Calcutt, M. Calin, S. Calvez, E. Calvo, A. Caminata, M. Campanelli, D. Caratelli, D. Carber, J. Carceller, G. Carini, B. Carlus, M. F. Carneiro, P. Carniti, I. Caro Terrazas, H. Carranza, T. Carroll, J. F. Castaño Forero, A. Castillo, C. Castromonte, E. Catano-Mur, C. Cattadori, F. Cavalier, G. Cavallaro, F. Cavanna, S. Centro, G. Cerati, A. Cervelli, A. Cervera Villanueva, M. Chalifour, A. Chappell, E. Chardonnet, N. Charitonidis, A. Chatterjee, S. Chattopadhyay, M. Chavarry Neyra, H. Chen, M. Chen, Y. Chen, Z. Chen, Z. Chen-Wishart, Y. Cheon, D. Cherdack, C. Chi, S. Childress, R. Chirco, A. Chiriacescu, G. Chisnall, K. Cho, S. Choate, D. Chokheli, P. S. Chong, A. Christensen, D. Christian, G. Christodoulou, A. Chukanov, M. Chung, E. Church, V. Cicero, P. Clarke, G. Cline, T. E. Coan, A. G. Cocco, J. Coelho, N. Colton, E. Conley, R. Conley, J. Conrad, M. Convery, S. Copello, P. Cova, L. Cremaldi, L. Cremonesi, J. I. Crespo-Anadón, M. Crisler, E. Cristaldo, J. Crnkovic, R. Cross, A. Cudd, C. Cuesta, Y. Cui, D. Cussans, O. Dalager, H. Da Motta, L. Da Silva Peres, C. David, Q. David, G. S. Davies, S. Davini, J. Dawson, K. De, S. De, P. Debbins, I. De Bonis, M. Decowski, A. De Gouvea, P. C. De Holanda, I. L. De Icaza Astiz, A. Deisting, P. De Jong, A. Delbart, D. Delepine, M. Delgado, A. Dell’Acqua, N. Delmonte, P. De Lurgio, J. R. De Mello Neto, D. M. DeMuth, S. Dennis, C. Densham, G. W. Deptuch, A. De Roeck, V. De Romeri, G. De Souza, R. Devi, R. Dharmapalan, M. Dias, F. Diaz, J. Diaz, S. Di Domizio, L. Di Giulio, P. Ding, L. Di Noto, G. Dirkx, C. Distefano, R. Diurba, M. Diwan, Z. Djurcic, D. Doering, S. Dolan, F. Dolek, M. Dolinski, L. Domine, Y. Donon, D. Douglas, D. Douillet, A. Dragone, G. Drake, F. Drielsma, L. Duarte, D. Duchesneau, K. Duffy, P. Dunne, B. Dutta, H. Duyang, O. Dvornikov, D. Dwyer, A. Dyshkant, M. Eads, A. Earle, D. Edmunds, J. Eisch, L. Emberger, S. Emery, P. Englezos, A. Ereditato, T. Erjavec, C. Escobar, G. Eurin, J. J. Evans, E. Ewart, A. C. Ezeribe, K. Fahey, A. Falcone, M. Fani’, C. Farnese, Y. Farzan, D. Fedoseev, J. Felix, Y. Feng, E. Fernandez-Martinez, P. Fernandez Menendez, M. Fernandez Morales, F. Ferraro, L. Fields, P. Filip, F. Filthaut, M. Fiorini, V. Fischer, R. S. Fitzpatrick, W. Flanagan, B. Fleming, R. Flight, S. Fogarty, W. Foreman, J. Fowler, W. Fox, J. Franc, K. Francis, D. Franco, J. Freeman, J. Freestone, J. Fried, A. Friedland, F. Fuentes Robayo, S. Fuess, I. K. Furic, K. Furman, A. P. Furmanski, A. Gabrielli, A. Gago, H. Gallagher, A. Gallas, A. Gallego-Ros, N. Gallice, V. Galymov, E. Gamberini, T. Gamble, F. Ganacim, R. Gandhi, R. Gandrajula, F. Gao, S. Gao, D. Garcia-Gamez, M. Á. García-Peris, S. Gardiner, D. Gastler, J. Gauvreau, G. Ge, N. Geffroy, B. Gelli, A. Gendotti, S. Gent, Z. Ghorbani-Moghaddam, P. Giammaria, T. Giammaria, N. Giangiacomi, D. Gibin, I. Gil-Botella, S. Gilligan, C. Girerd, A. Giri, D. Gnani, O. Gogota, M. Gold, S. Gollapinni, K. Gollwitzer, R. A. Gomes, L. Gomez Bermeo, L. S. Gomez Fajardo, F. Gonnella, D. Gonzalez-Diaz, M. Gonzalez-Lopez, M. C. Goodman, O. Goodwin, S. Goswami, C. Gotti, E. Goudzovski, C. Grace, R. Gran, E. Granados, P. Granger, A. Grant, C. Grant, D. Gratieri, P. Green, L. Greenler, J. Greer, J. Grenard, C. Griffith, M. Groh, J. Grudzinski, K. Grzelak, W. Gu, E. Guardincerri, V. Guarino, M. Guarise, R. Guenette, E. Guerard, M. Guerzoni, D. Guffanti, A. Guglielmi, B. Guo, A. Gupta, V. Gupta, K. Guthikonda, R. Gutierrez, P. Guzowski, M. M. Guzzo, S. Gwon, C. Ha, K. Haaf, A. Habig, H. Hadavand, R. Haenni, A. Hahn, J. Haiston, P. Hamacher-Baumann, T. Hamernik, P. Hamilton, J. Han, D. A. Harris, J. Hartnell, T. Hartnett, J. Harton, T. Hasegawa, C. Hasnip, R. Hatcher, K. W. Hatfield, A. Hatzikoutelis, C. Hayes, K. Hayrapetyan, J. Hays, E. Hazen, M. He, A. Heavey, K. M. Heeger, J. Heise, S. Henry, M. Hernandez Morquecho, K. Herner, J. Hewes, C. Hilgenberg, T. Hill, S. J. Hillier, A. Himmel, E. Hinkle, L. R. Hirsch, J. Ho, J. Hoff, A. Holin, E. Hoppe, G. A. Horton-Smith, M. Hostert, A. Hourlier, B. Howard, R. Howell, J. Hoyos, I. Hristova, M. S. Hronek, J. Huang, Z. Hulcher, G. Iles, N. Ilic, A. M. Iliescu, R. Illingworth, G. Ingratta, A. Ioannisian, B. Irwin, L. Isenhower, R. Itay, C. M. Jackson, V. Jain, E. James, W. Jang, B. Jargowsky, F. Jediny, D. Jena, Y. Jeong, C. Jesús-Valls, X. Ji, L. Jiang, S. Jiménez, A. Jipa, R. Johnson, W. Johnson, N. Johnston, B. Jones, S. Jones, M. Judah, C. Jung, T. Junk, Y. Jwa, M. Kabirnezhad, A. Kaboth, I. Kadenko, I. Kakorin, A. Kalitkina, D. Kalra, F. Kamiya, N. Kaneshige, D. M. Kaplan, G. Karagiorgi, G. Karaman, A. Karcher, M. Karolak, Y. Karyotakis, S. Kasai, S. P. Kasetti, L. Kashur, N. Kazaryan, E. Kearns, P. Keener, K. J. Kelly, E. Kemp, O. Kemularia, W. Ketchum, S. H. Kettell, M. Khabibullin, A. Khotjantsev, A. Khvedelidze, D. Kim, B. King, B. Kirby, M. Kirby, J. Klein, A. Klustova, T. Kobilarcik, K. Koehler, L. W. Koerner, D. H. Koh, S. Kohn, P. P. Koller, L. Kolupaeva, D. Korablev, M. Kordosky, T. Kosc, U. Kose, V. Kostelecky, K. Kothekar, R. Kralik, L. Kreczko, F. Krennrich, I. Kreslo, W. Kropp, T. Kroupova, S. Kubota, Y. Kudenko, V. A. Kudryavtsev, S. Kulagin, J. Kumar, P. Kumar, P. Kunze, N. Kurita, C. Kuruppu, V. Kus, T. Kutter, J. Kvasnicka, D. Kwak, A. Lambert, B. Land, C. E. Lane, K. Lang, T. Langford, M. Langstaff, J. Larkin, P. Lasorak, D. Last, A. Laundrie, G. Laurenti, A. Lawrence, I. Lazanu, R. LaZur, M. Lazzaroni, T. Le, S. Leardini, J. Learned, P. LeBrun, T. LeCompte, C. Lee, S. Lee, G. Lehmann Miotto, R. Lehnert, M. Leigui de Oliveira, M. Leitner, L. M. Lepin, S. Li, Y. Li, H. Liao, C. Lin, Q. Lin, S. Lin, R. A. Lineros, J. Ling, A. Lister, B. R. Littlejohn, J. Liu, Y. Liu, S. Lockwitz, T. Loew, M. Lokajicek, I. Lomidze, K. Long, T. Lord, J. LoSecco, W. C. Louis, X. Lu, K. Luk, B. Lunday, X. Luo, E. Luppi, T. Lux, V. P. Luzio, J. Maalmi, D. MacFarlane, A. Machado, P. Machado, C. Macias, J. Macier, A. Maddalena, A. Madera, P. Madigan, S. Magill, K. Mahn, A. Maio, A. Major, J. A. Maloney, G. Mandrioli, R. C. Mandujano, J. C. Maneira, L. Manenti, S. Manly, A. Mann, K. Manolopoulos, M. Manrique Plata, V. N. Manyam, L. Manzanillas, M. Marchan, A. Marchionni, W. Marciano, D. Marfatia, C. Mariani, J. Maricic, R. Marie, F. Marinho, A. D. Marino, D. Marsden, M. Marshak, C. Marshall, J. Marshall, J. Marteau, J. Martin-Albo, N. Martinez, D. A. Martinez Caicedo, P. Martínez Miravé, S. Martynenko, V. Mascagna, K. Mason, A. Mastbaum, F. Matichard, S. Matsuno, J. Matthews, C. Mauger, N. Mauri, K. Mavrokoridis, I. Mawby, R. Mazza, A. Mazzacane, E. Mazzucato, T. McAskill, E. McCluskey, N. McConkey, K. S. McFarland, C. McGrew, A. McNab, A. Mefodiev, P. Mehta, P. Melas, O. Mena, H. Mendez, P. Mendez, D. P. Méndez, A. Menegolli, G. Meng, M. Messier, W. Metcalf, T. Mettler, M. Mewes, H. Meyer, T. Miao, G. Michna, T. Miedema, V. Mikola, R. Milincic, G. Miller, W. Miller, J. Mills, O. Mineev, A. Minotti, O. G. Miranda, S. Miryala, C. Mishra, S. Mishra, A. Mislivec, M. Mitchell, D. Mladenov, I. Mocioiu, K. Moffat, N. Moggi, R. Mohanta, T. A. Mohayai, N. Mokhov, J. A. Molina, L. Molina Bueno, E. Montagna, A. Montanari, C. Montanari, D. Montanari, L. M. Montano Zetina, S. Moon, M. Mooney, A. F. Moor, D. Moreno, D. Moretti, C. Morris, C. Mossey, M. Mote, E. Motuk, C. A. Moura, J. Mousseau, G. Mouster, W. Mu, L. Mualem, J. Mueller, M. Muether, S. Mufson, F. Muheim, A. Muir, M. Mulhearn, D. Munford, H. Muramatsu, S. Murphy, J. Musser, J. Nachtman, S. Nagu, M. Nalbandyan, R. Nandakumar, D. Naples, S. Narita, A. Nath, A. Navrer-Agasson, N. Nayak, M. Nebot-Guinot, K. Negishi, J. K. Nelson, J. Nesbit, M. Nessi, D. Newbold, M. Newcomer, H. Newton, R. Nichol, F. Nicolas-Arnaldos, A. Nikolica, E. Niner, K. Nishimura, A. Norman, A. Norrick, R. Northrop, P. Novella, J. A. Nowak, M. Oberling, J. Ochoa-Ricoux, A. Olivier, A. Olshevskiy, Y. Onel, Y. Onishchuk, J. Ott, L. Pagani, G. Palacio, O. Palamara, S. Palestini, J. M. Paley, M. Pallavicini, C. Palomares, W. Panduro Vazquez, E. Pantic, V. Paolone, V. Papadimitriou, R. Papaleo, A. Papanestis, S. Paramesvaran, S. Parke, E. Parozzi, Z. Parsa, M. Parvu, S. Pascoli, L. Pasqualini, J. Pasternak, J. Pater, C. Patrick, L. Patrizii, R. B. Patterson, S. Patton, T. Patzak, A. Paudel, B. Paulos, L. Paulucci, Z. Pavlovic, G. Pawloski, D. Payne, V. Pec, S. J. Peeters, A. Pena Perez, E. Pennacchio, A. Penzo, O. L. Peres, J. Perry, D. Pershey, G. Pessina, G. Petrillo, C. Petta, R. Petti, V. Pia, F. Piastra, L. Pickering, F. Pietropaolo, V. L. Pimentel, G. Pinaroli, K. Plows, R. Plunkett, R. Poling, F. Pompa, X. Pons, N. Poonthottathil, F. Poppi, S. Pordes, J. Porter, M. Potekhin, R. Potenza, B. V. Potukuchi, J. Pozimski, M. Pozzato, S. Prakash, T. Prakash, M. Prest, S. Prince, F. Psihas, D. Pugnere, X. Qian, J. Raaf, V. Radeka, J. Rademacker, B. Radics, A. Rafique, E. Raguzin, M. Rai, M. Rajaoalisoa, I. Rakhno, A. Rakotonandrasana, L. Rakotondravohitra, R. Rameika, M. Ramirez Delgado, B. Ramson, A. Rappoldi, G. Raselli, P. Ratoff, S. Raut, R. Razakamiandra, E. Rea, J. Real, B. Rebel, R. Rechenmacher, M. Reggiani-Guzzo, J. Reichenbacher, S. D. Reitzner, H. Rejeb Sfar, A. Renshaw, S. Rescia, F. Resnati, A. Reynolds, M. Ribas, S. Riboldi, C. Riccio, G. Riccobene, L. C. Rice, J. Ricol, A. Rigamonti, Y. Rigaut, E. V. Rincón, H. Ritchie-Yates, D. Rivera, A. Robert, L. Rochester, M. Roda, P. Rodrigues, M. J. Rodriguez Alonso, E. Rodriguez Bonilla, J. Rodriguez Rondon, S. Rosauro-Alcaraz, M. Rosenberg, P. Rosier, B. Roskovec, M. Rossella, M. Rossi, J. Rout, P. Roy, A. Rubbia, C. Rubbia, B. Russell, D. Ruterbories, A. Rybnikov, A. Saa-Hernandez, R. Saakyan, S. Sacerdoti, T. Safford, N. Sahu, P. Sala, N. Samios, O. Samoylov, M. Sanchez, V. Sandberg, D. A. Sanders, D. Sankey, S. Santana, M. Santos-Maldonado, N. Saoulidou, P. Sapienza, C. Sarasty, I. Sarcevic, G. Savage, V. Savinov, A. Scaramelli, A. Scarff, A. Scarpelli, T. Schefke, H. Schellman, S. Schifano, P. Schlabach, D. Schmitz, A. W. Schneider, K. Scholberg, A. Schukraft, E. Segreto, A. Selyunin, C. R. Senise, J. Sensenig, A. Sergi, D. Sgalaberna, M. Shaevitz, S. Shafaq, F. Shaker, M. Shamma, R. Sharankova, H. R. Sharma, R. Sharma, R. K. Sharma, T. Shaw, K. Shchablo, C. Shepherd-Themistocleous, A. Sheshukov, S. Shin, I. Shoemaker, D. Shooltz, R. Shrock, H. Siegel, L. Simard, J. Sinclair, G. Sinev, J. Singh, L. Singh, P. Singh, V. Singh, R. Sipos, F. Sippach, G. Sirri, A. Sitraka, K. Siyeon, K. Skarpaas, A. Smith, E. Smith, P. Smith, J. Smolik, M. Smy, E. Snider, P. Snopok, D. Snowden-Ifft, M. Soares Nunes, H. Sobel, M. Soderberg, S. Sokolov, C. J. Solano Salinas, S. Söldner-Rembold, S. Soleti, N. Solomey, V. Solovov, W. E. Sondheim, M. Sorel, A. Sotnikov, J. Soto-Oton, F. Soto Ugaldi, A. Sousa, K. Soustruznik, F. Spagliardi, M. Spanu, J. Spitz, N. J. C. Spooner, K. Spurgeon, M. Stancari, L. Stanco, C. Stanford, D. Stefan, R. Stein, H. Steiner, A. F. Steklain Lisbôa, J. Stewart, B. Stillwell, J. Stock, F. Stocker, T. Stokes, M. Strait, T. Strauss, L. Strigari, A. Stuart, J. G. Suarez, J. Suárez Sunción, R. Sulej, H. Sullivan, D. Summers, A. Surdo, V. Susic, L. Suter, C. Sutera, R. Svoboda, B. Szczerbinska, A. M. Szelc, H. Tanaka, S. Tang, A. Tapia, B. Tapia Oregui, A. Tapper, S. Tariq, E. Tarpara, N. Tata, E. Tatar, R. Tayloe, A. Teklu, P. Tennessen, M. Tenti, K. Terao, C. A. Ternes, F. Terranova, G. Testera, T. Thakore, A. Thea, J. L. Thompson, C. Thorn, S. Timm, V. Tishchenko, L. Tomassetti, A. Tonazzo, D. Torbunov, M. Torti, M. Tortola, F. Tortorici, N. Tosi, D. Totani, M. Toups, C. Touramanis, R. Travaglini, J. Trevor, S. Trilov, W. H. Trzaska, Y. Tsai, Z. Tsamalaidze, K. Tsang, N. Tsverava, S. Tufanli, C. Tull, E. Tyley, M. Tzanov, L. Uboldi, M. A. Uchida, J. Urheim, T. Usher, S. Uzunyan, M. R. Vagins, P. Vahle, S. Valder, G. A. Valdiviesso, E. Valencia, R. Valentim, Z. Vallari, E. Vallazza, J. W. Valle, S. Vallecorsa, R. Van Berg, R. G. Van de Water, D. Vanegas Forero, D. Vannerom, F. Varanini, D. Vargas, G. Varner, J. Vasel, S. Vasina, G. Vasseur, N. Vaughan, K. Vaziri, S. Ventura, A. Verdugo, S. Vergani, M. A. Vermeulen, M. Verzocchi, M. Vicenzi, H. Vieira de Souza, C. Vignoli, C. Vilela, B. Viren, T. Vrba, T. Wachala, A. V. Waldron, M. Wallbank, C. Wallis, H. Wang, J. Wang, L. Wang, M. H. Wang, X. Wang, Y. Wang, K. Warburton, D. Warner, M. Wascko, D. Waters, A. Watson, K. Wawrowska, P. Weatherly, A. Weber, M. Weber, H. Wei, A. Weinstein, D. Wenman, M. Wetstein, A. White, L. H. Whitehead, D. Whittington, M. J. Wilking, A. Wilkinson, C. Wilkinson, Z. Williams, F. Wilson, R. J. Wilson, W. Wisniewski, J. Wolcott, T. Wongjirad, A. Wood, K. Wood, E. Worcester, M. Worcester, K. Wresilo, C. Wret, W. Wu, Y. Xiao, F. Xie, B. Yaeggy, E. Yandel, G. Yang, K. Yang, T. Yang, A. Yankelevich, N. Yershov, K. Yonehara, Y. Yoon, T. Young, B. Yu, H. Yu, J. Yu, Y. Yu, W. Yuan, R. Zaki, J. Zalesak, L. Zambelli, B. Zamorano, A. Zani, L. Zazueta, G. Zeller, J. Zennamo, K. Zeug, C. Zhang, S. Zhang, Y. Zhang, M. Zhao, E. Zhivun, G. Zhu, E. D. Zimmerman, S. Zucchelli, J. Zuklin, V. Zutshi, and R. Zwaska

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagnetic cascades. Results from testing the algorithm on experimental data from ProtoDUNE-SP, a prototype of the DUNE far detector, are presented. The network identifies track- and shower-like particles, as well as Michel electrons, with high efficiency. The performance of the algorithm is consistent between experimental data and simulation.

Published
2022
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157. Embodied Contradictions and Post-Industrial Built Environments

Author

Benjamin A. Bross

Subjects
modernist architecture, post-industrial environments, spatial contradictions, commodified heritage, Architecture, NA1-9428
Abstract

In October of 2004, the Museo de Medicina Laboral (Museum of Labor Medicine), opened to the public in Real del Monte, State of Hidalgo, Mexico. The museum, located on the grounds of what had been the Hospital Minero (Mining Hospital), was a building complex conceived, built, and operationalized at the height of Mexico’s Industrial Revolution and the region’s only medical facility specializing in the healthcare needs of miners and their families. Utilizing historical analysis, the hospital reveals contradictions frequently embodied by the era’s Modernist built environments. Inaugurated in 1907, the hospital was the culmination of the United States Smelting Refining and Mining Company (USSRMC) and its Mexican subsidiary, Compañía Real del Monte y Pachuca’s (CRMyP) efforts to bring healthcare to its employees while maximizing production. On one hand, the hospital’s design and operation expressed an optimism wrought by the dissemination of positivist and utilitarian philosophies and economic growth spurred by technological innovation; on the other, growing wealth inequality and deteriorating, often brutal, labor conditions. Nearly 120 years later, the hospital again embodies a global reality. In contemporary post-industrialist economies, once these built environments cease being productive, they are usually abandoned or demolished; only a few are transformed and repositioned for other uses. As the region’s mining industry ceased productivity, the hospital was first abandoned and later rescued by a newly privatized enterprise that donated the medical building complex to a non-for-profit civil association focused on mining heritage. Now the Museum, an architectural expression that fused global and local economic, technological, and aesthetic sensibilities, has become an example of commodified didactic heritage.

Published
2023
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158. Interaction of sortilin with apolipoprotein E3 enables neurons to use long-chain fatty acids as alternative metabolic fuel

Author

Willnow, Thomas, primary, Greda, Ania K, additional, Gomes, Jemila P, additional, Zurawska-Plaksej, Ewa, additional, Raphaela Fritsche-Guenther, Raphaela, additional, Rudolph, Ina-Maria, additional, Telugu, Narasimha S, additional, Coemert, Cagla, additional, Kirwan, Jennifer, additional, Kunz, Severine, additional, Rothe, Michael, additional, Diecke, Sebastian, additional, and Bross, Peter, additional

Published
2024
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161. First particle-by-particle measurement of emittance in the Muon Ionization Cooling Experiment

Author

The MICE Collaboration, Adams, D., Adey, D., Asfandiyarov, R., Barber, G., de Bari, A., Bayes, R., Bayliss, V., Bertoni, R., Blackmore, V., Blondel, A., Boehm, J., Bogomilov, M., Bonesini, M., Booth, C. N., Bowring, D., Boyd, S., Bradshaw, T. W., Bross, A. D., Brown, C., Coney, L., Charnley, G., Chatzitheodoridis, G. T., Chignoli, F., Chung, M., Cline, D., Cobb, J. H., Colling, D., Collomb, N., Cooke, P., Courthold, M., Cremaldi, L. M., DeMello, A., Dick, A. J., Dobbs, A., Dornan, P., Drielsma, F., Dumbell, K., Ellis, M., Filthaut, F., Franchini, P., Freemire, B., Gallagher, A., Gamet, R., Gardener, R. B. S., Gourlay, S., Grant, A., Greis, J. R., Griffiths, S., Hanlet, P., Hanson, G. G., Hartnett, T., Heidt, C., Hodgson, P., Hunt, C., Ishimoto, S., Jokovic, D., Jurj, P. B., Kaplan, D. M., Karadzhov, Y., Klier, A., Kuno, Y., Kurup, A., Kyberd, P., Lagrange, J-B., Langlands, J., Lau, W., Li, D., Li, Z., Liu, A., Long, K., Lord, T., Macwaters, C., Maletic, D., Martlew, B., Martyniak, J., Mazza, R., Middleton, S., Mohayai, T. A., Moss, A., Muir, A., Mullacrane, I., Nebrensky, J. J., Neuffer, D., Nichols, A., Nugent, J. C., Oates, A., Orestano, D., Overton, E., Owens, P., Palladino, V., Palmer, M., Pasternak, J., Pec, V., Pidcott, C., Popovic, M., Preece, R., Prestemon, S., Rajaram, D., Ricciardi, S., Robinson, M., Rogers, C., Ronald, K., Rubinov, P., Sakamoto, H., Sanders, D. A., Sato, A., Savic, M., Snopok, P., Smith, P. J., Soler, F. J. P., Song, Y., Stanley, T., Stokes, G., Suezaki, V., Summers, D. J., Sung, C. K., Tang, J., Tarrant, J., Taylor, I., Tortora, L., Torun, Y., Tsenov, R., Tucker, M., Uchida, M. A., Virostek, S., Vankova-Kirilova, G., Warburton, P., Wilbur, S., Wilson, A., Witte, H., White, C., Whyte, C. G., Yang, X., Young, A. R., and Zisman, M.

Subjects
Physics - Accelerator Physics, Physics - Instrumentation and Detectors
Abstract

The Muon Ionization Cooling Experiment (MICE) collaboration seeks to demonstrate the feasibility of ionization cooling, the technique by which it is proposed to cool the muon beam at a future neutrino factory or muon collider. The emittance is measured from an ensemble of muons assembled from those that pass through the experiment. A pure muon ensemble is selected using a particle-identification system that can reject efficiently both pions and electrons. The position and momentum of each muon are measured using a high-precision scintillating-fibre tracker in a 4\,T solenoidal magnetic field. This paper presents the techniques used to reconstruct the phase-space distributions and reports the first particle-by-particle measurement of the emittance of the MICE Muon Beam as a function of muon-beam momentum.

Published
2018
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162. Operation of normal-conducting RF cavities in multi-tesla magnetic fields for muon ionization cooling: a feasibility demonstration

Author

Bowring, Daniel, Kochemirovskiy, Alexey, Torun, Yagmur, Adolphsen, Chris, Bross, Alan, Chung, Moses, Freemire, Ben, Ge, Lixin, Haase, Andrew, Lane, Peter, Leonova, Maria, Li, Derun, Li, Zenghai, Liu, Ao, Luo, Tianhuan, Martin, David, Moretti, Alfred, Neuffer, David, Pasquinelli, Ralph, Palmer, Mark, Peterson, David, Popovic, Milorad, Stratakis, Diktys, and Yonehara, Katsuya

Subjects
Physics - Accelerator Physics
Abstract

Ionization cooling is the preferred method for producing bright muon beams. This cooling technique requires the operation of normal conducting, radio-frequency (RF) accelerating cavities within the multi-tesla fields of DC solenoid magnets. Under these conditions, cavities exhibit increased susceptibility to RF breakdown, which can damage channel components and imposes limits on channel length and transmission efficiency. We present a solution to the problem of breakdown in strong magnetic fields. We report, for the first time, stable high-vacuum, copper cavity operation at gradients above 50 MV/m and in an external magnetic field of three tesla. This eliminates a significant technical risk that has previously been inherent in ionization cooling channel designs., Comment: 7 pages, 7 figures

Published
2018
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163. nuSTORM FFAG Decay Ring

Author

Lagrange, J. -B., Pasternak, J., Appleby, R. B., Garland, J. M., Owen, H., Tygier, S., Bross, A., and Liu, A.

Subjects
Physics - Accelerator Physics
Abstract

The neutrino beam produced from muons decaying in a storage ring would be an ideal tool for precise neutrino cross section measurements and search for sterile neutrinos due to its precisely known flavour content and spectrum. In the proposed nuSTORM facility pions would be directly injected into a racetrack storage ring, where circulating muon beam would be captured. The storage ring has two options: a FODO solution with large aperture quadrupoles and a racetrack FFAG (Fixed Field Alternating Gradient) using the recent developments in FFAGs. Machine parameters, linear optics design and beam dynamics are discussed in this paper., Comment: 3 pp. Proceedings of IPAC2016, Busan, Korea

Published
2018

164. Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease

Author

Schwimmer, Jeffrey B, Johnson, Jethro S, Angeles, Jorge E, Behling, Cynthia, Belt, Patricia H, Borecki, Ingrid, Bross, Craig, Durelle, Janis, Goyal, Nidhi P, Hamilton, Gavin, Holtz, Mary L, Lavine, Joel E, Mitreva, Makedonka, Newton, Kimberly P, Pan, Amy, Simpson, Pippa M, Sirlin, Claude B, Sodergren, Erica, Tyagi, Rahul, Yates, Katherine P, Weinstock, George M, and Salzman, Nita H

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nutrition and Dietetics, Clinical Research, Biotechnology, Genetics, Liver Disease, Chronic Liver Disease and Cirrhosis, Digestive Diseases, Pediatric, Hepatitis, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Adolescent, Bacteria, Case-Control Studies, Child, Cross-Sectional Studies, DNA, Bacterial, Dysbiosis, Feces, Female, Gastrointestinal Microbiome, Host-Pathogen Interactions, Humans, Intestines, Liver Cirrhosis, Male, Metagenome, Non-alcoholic Fatty Liver Disease, Prospective Studies, RNA, Ribosomal, 16S, Ribotyping, Severity of Illness Index, Intestinal Microbiota, Lipopolysaccharide, Flagellin, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsThe intestinal microbiome might affect the development and severity of nonalcoholic fatty liver disease (NAFLD). We analyzed microbiomes of children with and without NAFLD.MethodsWe performed a prospective, observational, cross-sectional study of 87 children (age range, 8-17 years) with biopsy-proven NAFLD and 37 children with obesity without NAFLD (controls). Fecal samples were collected and microbiome composition and functions were assessed using 16S ribosomal RNA amplicon sequencing and metagenomic shotgun sequencing. Microbial taxa were identified using zero-inflated negative binomial modeling. Genes contributing to bacterial pathways were identified using gene set enrichment analysis.ResultsFecal microbiomes of children with NAFLD had lower α-diversity than those of control children (3.32 vs 3.52, P = .016). Fecal microbiomes from children with nonalcoholic steatohepatitis (NASH) had the lowest α-diversity (control, 3.52; NAFLD, 3.36; borderline NASH, 3.37; NASH, 2.97; P = .001). High abundance of Prevotella copri was associated with more severe fibrosis (P = .036). Genes for lipopolysaccharide biosynthesis were enriched in microbiomes from children with NASH (P < .001). Classification and regression tree model with level of alanine aminotransferase and relative abundance of the lipopolysaccharide pathway gene encoding 3-deoxy-d-manno-octulosonate 8-phosphate-phosphatase identified patients with NASH with an area under the receiver operating characteristic curve value of 0.92. Genes involved in flagellar assembly were enriched in the fecal microbiomes of patients with moderate to severe fibrosis (P < .001). Classification and regression tree models based on level of alanine aminotransferase and abundance of genes encoding flagellar biosynthesis protein had good accuracy for identifying case children with moderate to severe fibrosis (area under the receiver operating characteristic curve, 0.87).ConclusionsIn an analysis of fecal microbiomes of children with NAFLD, we associated NAFLD and NASH with intestinal dysbiosis. NAFLD and its severity were associated with greater abundance of genes encoding inflammatory bacterial products. Alterations to the intestinal microbiome might contribute to the pathogenesis of NAFLD and be used as markers of disease or severity.

Published
2019

165. First particle-by-particle measurement of emittance in the Muon Ionization Cooling Experiment

Author

Adams, D, Adey, D, Asfandiyarov, R, Barber, G, de Bari, A, Bayes, R, Bayliss, V, Bertoni, R, Blackmore, V, Blondel, A, Boehm, J, Bogomilov, M, Bonesini, M, Booth, CN, Bowring, D, Boyd, S, Bradshaw, TW, Bross, AD, Brown, C, Charnley, G, Chatzitheodoridis, GT, Chignoli, F, Chung, M, Cline, D, Cobb, JH, Colling, D, Collomb, N, Cooke, P, Courthold, M, Cremaldi, LM, DeMello, A, Dick, AJ, Dobbs, A, Dornan, P, Drielsma, F, Dumbell, K, Ellis, M, Filthaut, F, Franchini, P, Freemire, B, Gallagher, A, Gamet, R, Gardener, RBS, Gourlay, S, Grant, A, Greis, JR, Griffiths, S, Hanlet, P, Hanson, GG, Hartnett, T, Heidt, C, Hodgson, P, Hunt, C, Ishimoto, S, Jokovic, D, Jurj, PB, Kaplan, DM, Karadzhov, Y, Klier, A, Kuno, Y, Kurup, A, Kyberd, P, Lagrange, J-B, Langlands, J, Lau, W, Li, D, Li, Z, Liu, A, Long, K, Lord, T, Macwaters, C, Maletic, D, Martlew, B, Martyniak, J, Mazza, R, Middleton, S, Mohayai, TA, Moss, A, Muir, A, Mullacrane, I, Nebrensky, JJ, Neuffer, D, Nichols, A, Nugent, JC, Oates, A, Orestano, D, Overton, E, Owens, P, Palladino, V, Palmer, M, Pasternak, J, Pec, V, Pidcott, C, Popovic, M, Preece, R, Prestemon, S, Rajaram, D, Ricciardi, S, Robinson, M, and Rogers, C

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Synchrotrons and Accelerators, Physical Sciences, physics.acc-ph, physics.ins-det, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Astronomical sciences, Atomic, molecular and optical physics, Particle and high energy physics
Abstract

The Muon Ionization Cooling Experiment (MICE) collaboration seeks to demonstrate the feasibility of ionization cooling, the technique by which it is proposed to cool the muon beam at a future neutrino factory or muon collider. The emittance is measured from an ensemble of muons assembled from those that pass through the experiment. A pure muon ensemble is selected using a particle-identification system that can reject efficiently both pions and electrons. The position and momentum of each muon are measured using a high-precision scintillating-fibre tracker in a 4 T solenoidal magnetic field. This paper presents the techniques used to reconstruct the phase-space distributions in the upstream tracking detector and reports the first particle-by-particle measurement of the emittance of the MICE Muon Beam as a function of muon-beam momentum.

Published
2019

166. The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation

Author

Veerle Paternoster, Cagla Cömert, Louise Sand Kirk, Sanne Hage la Cour, Tue Fryland, Paula Fernandez-Guerra, Magnus Stougaard, Jens Randel Nyengaard, Per Qvist, Peter Bross, Anders Dupont Børglum, and Jane Hvarregaard Christensen

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Bromodomain containing 1 (BRD1) encodes an epigenetic regulator that controls the expression of genetic networks linked to mental illness. BRD1 is essential for normal brain development and its role in psychopathology has been demonstrated in genetic and preclinical studies. However, the neurobiology that bridges its molecular and neuropathological effects remains poorly explored. Here, using publicly available datasets, we find that BRD1 targets nuclear genes encoding mitochondrial proteins in cell lines and that modulation of BRD1 expression, irrespective of whether it is downregulation or upregulation of one or the other existing BRD1 isoforms (BRD1-L and BRD1-S), leads to distinct shifts in the expression profile of these genes. We further show that the expression of nuclear genes encoding mitochondrial proteins is negatively correlated with the expression of BRD1 mRNA during human brain development. In accordance, we identify the key gate-keeper of mitochondrial metabolism, Peroxisome proliferator-activated receptor (PPAR) among BRD1’s co-transcription factors and provide evidence that BRD1 acts as a co-repressor of PPAR-mediated transcription. Lastly, when using quantitative PCR, mitochondria-targeted fluorescent probes, and the Seahorse XFe96 Analyzer, we demonstrate that modulation of BRD1 expression in cell lines alters mitochondrial physiology (mtDNA content and mitochondrial mass), metabolism (reducing power), and bioenergetics (among others, basal, maximal, and spare respiration) in an expression level- and isoform-dependent manner. Collectively, our data suggest that BRD1 is a transcriptional regulator of nuclear-encoded mitochondrial proteins and that disruption of BRD1’s genomic actions alters mitochondrial functions. This may be the mechanism underlying the cellular and atrophic changes of neurons previously associated with BRD1 deficiency and suggests that mitochondrial dysfunction may be a possible link between genetic variation in BRD1 and psychopathology in humans.

Published
2022
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167. Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC

Author

A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, M. Adamowski, D. Adams, M. Adinolfi, A. Aduszkiewicz, J. Aguilar, Z. Ahmad, J. Ahmed, B. Aimard, B. Ali-Mohammadzadeh, T. Alion, K. Allison, S. Alonso Monsalve, M. AlRashed, C. Alt, A. Alton, R. Alvarez, P. Amedo, J. Anderson, C. Andreopoulos, M. Andreotti, M. Andrews, F. Andrianala, S. Andringa, N. Anfimov, A. Ankowski, M. Antoniassi, M. Antonova, A. Antoshkin, S. Antusch, A. Aranda-Fernandez, L. Arellano, L. O. Arnold, M. A. Arroyave, J. Asaadi, L. Asquith, A. Aurisano, V. Aushev, D. Autiero, V. Ayala Lara, M. Ayala-Torres, F. Azfar, A. Back, H. Back, J. J. Back, C. Backhouse, I. Bagaturia, L. Bagby, N. Balashov, S. Balasubramanian, P. Baldi, B. Baller, B. Bambah, F. Barao, G. Barenboim, P. Barham Alzas, G. Barker, W. Barkhouse, C. Barnes, G. Barr, J. Barranco Monarca, A. Barros, N. Barros, J. L. Barrow, A. Basharina-Freshville, A. Bashyal, V. Basque, C. Batchelor, E. Batista das Chagas, J. B. R. Battat, F. Battisti, F. Bay, M. C. Q. Bazetto, J. L. L. Bazo Alba, J. F. Beacom, E. Bechetoille, B. Behera, C. Beigbeder, L. Bellantoni, G. Bellettini, V. Bellini, O. Beltramello, N. Benekos, C. Benitez Montiel, F. Bento Neves, J. Berger, S. Berkman, P. Bernardini, R. M. Berner, A. Bersani, S. Bertolucci, M. Betancourt, A. Betancur Rodríguez, A. Bevan, Y. Bezawada, T. J. C. Bezerra, A. Bhardwaj, V. Bhatnagar, M. Bhattacharjee, D. Bhattarai, S. Bhuller, B. Bhuyan, S. Biagi, J. Bian, M. Biassoni, K. Biery, B. Bilki, M. Bishai, A. Bitadze, A. Blake, F. Blaszczyk, G. C. Blazey, E. Blucher, J. Boissevain, S. Bolognesi, T. Bolton, L. Bomben, M. Bonesini, M. Bongrand, C. Bonilla-Diaz, F. Bonini, A. Booth, F. Boran, S. Bordoni, A. Borkum, N. Bostan, P. Bour, C. Bourgeois, D. Boyden, J. Bracinik, D. Braga, D. Brailsford, A. Branca, A. Brandt, J. Bremer, D. Breton, C. Brew, S. J. Brice, C. Brizzolari, C. Bromberg, J. Brooke, A. Bross, G. Brunetti, M. Brunetti, N. Buchanan, H. Budd, I. Butorov, I. Cagnoli, T. Cai, D. Caiulo, R. Calabrese, P. Calafiura, J. Calcutt, M. Calin, S. Calvez, E. Calvo, A. Caminata, M. Campanelli, D. Caratelli, D. Carber, J. C. Carceller, G. Carini, B. Carlus, M. F. Carneiro, P. Carniti, I. Caro Terrazas, H. Carranza, T. Carroll, J. F. Castaño Forero, A. Castillo, C. Castromonte, E. Catano-Mur, C. Cattadori, F. Cavalier, G. Cavallaro, F. Cavanna, S. Centro, G. Cerati, A. Cervelli, A. Cervera Villanueva, M. Chalifour, A. Chappell, E. Chardonnet, N. Charitonidis, A. Chatterjee, S. Chattopadhyay, M. S. S. Chavarry Neyra, H. Chen, M. Chen, Y. Chen, Z. Chen, Z. Chen-Wishart, Y. Cheon, D. Cherdack, C. Chi, S. Childress, R. Chirco, A. Chiriacescu, G. Chisnall, K. Cho, S. Choate, D. Chokheli, P. S. Chong, A. Christensen, D. Christian, G. Christodoulou, A. Chukanov, M. Chung, E. Church, V. Cicero, P. Clarke, G. Cline, T. E. Coan, A. G. Cocco, J. A. B. Coelho, N. Colton, E. Conley, R. Conley, J. Conrad, M. Convery, S. Copello, P. Cova, L. Cremaldi, L. Cremonesi, J. I. Crespo-Anadón, M. Crisler, E. Cristaldo, J. Crnkovic, R. Cross, A. Cudd, C. Cuesta, Y. Cui, D. Cussans, O. Dalager, H. da Motta, L. Da Silva Peres, C. David, Q. David, G. S. Davies, S. Davini, J. Dawson, K. De, S. De, P. Debbins, I. De Bonis, M. P. Decowski, A. De Gouvêa, P. C. De Holanda, I. L. De Icaza Astiz, A. Deisting, P. De Jong, A. Delbart, D. Delepine, M. Delgado, A. Dell’Acqua, N. Delmonte, P. De Lurgio, J. R. T. de Mello Neto, D. M. DeMuth, S. Dennis, C. Densham, G. W. Deptuch, A. De Roeck, V. De Romeri, G. De Souza, R. Devi, R. Dharmapalan, M. Dias, F. Diaz, J. S. Díaz, S. Di Domizio, L. Di Giulio, P. Ding, L. Di Noto, G. Dirkx, C. Distefano, R. Diurba, M. Diwan, Z. Djurcic, D. Doering, S. Dolan, F. Dolek, M. Dolinski, L. Domine, Y. Donon, D. Douglas, D. Douillet, A. Dragone, G. Drake, F. Drielsma, L. Duarte, D. Duchesneau, K. Duffy, P. Dunne, B. Dutta, H. Duyang, O. Dvornikov, D. Dwyer, A. Dyshkant, M. Eads, A. Earle, D. Edmunds, J. Eisch, L. Emberger, S. Emery, P. Englezos, A. Ereditato, T. Erjavec, C. Escobar, G. Eurin, J. J. Evans, E. Ewart, A. C. Ezeribe, K. Fahey, A. Falcone, M. Fani’, C. Farnese, Y. Farzan, D. Fedoseev, J. Felix, Y. Feng, E. Fernandez-Martinez, P. Fernandez Menendez, M. Fernandez Morales, F. Ferraro, L. Fields, P. Filip, F. Filthaut, M. Fiorini, V. Fischer, R. S. Fitzpatrick, W. Flanagan, B. Fleming, R. Flight, S. Fogarty, W. Foreman, J. Fowler, W. Fox, J. Franc, K. Francis, D. Franco, J. Freeman, J. Freestone, J. Fried, A. Friedland, F. Fuentes Robayo, S. Fuess, I. K. Furic, K. Furman, A. P. Furmanski, A. Gabrielli, A. Gago, H. Gallagher, A. Gallas, A. Gallego-Ros, N. Gallice, V. Galymov, E. Gamberini, T. Gamble, F. Ganacim, R. Gandhi, R. Gandrajula, F. Gao, S. Gao, D. Garcia-Gamez, M. Á. García-Peris, S. Gardiner, D. Gastler, J. Gauvreau, G. Ge, N. Geffroy, B. Gelli, A. Gendotti, S. Gent, Z. Ghorbani-Moghaddam, P. Giammaria, T. Giammaria, N. Giangiacomi, D. Gibin, I. Gil-Botella, S. Gilligan, C. Girerd, A. K. Giri, D. Gnani, O. Gogota, M. Gold, S. Gollapinni, K. Gollwitzer, R. A. Gomes, L. V. Gomez Bermeo, L. S. Gomez Fajardo, F. Gonnella, D. Gonzalez-Diaz, M. Gonzalez-Lopez, M. C. Goodman, O. Goodwin, S. Goswami, C. Gotti, E. Goudzovski, C. Grace, R. Gran, E. Granados, P. Granger, A. Grant, C. Grant, D. Gratieri, P. Green, L. Greenler, J. Greer, J. Grenard, W. C. Griffith, M. Groh, J. Grudzinski, K. Grzelak, W. Gu, E. Guardincerri, V. Guarino, M. Guarise, R. Guenette, E. Guerard, M. Guerzoni, D. Guffanti, A. Guglielmi, B. Guo, A. Gupta, V. Gupta, K. K. Guthikonda, R. Gutierrez, P. Guzowski, M. M. Guzzo, S. Gwon, C. Ha, K. Haaf, A. Habig, H. Hadavand, R. Haenni, A. Hahn, J. Haiston, P. Hamacher-Baumann, T. Hamernik, P. Hamilton, J. Han, D. A. Harris, J. Hartnell, T. Hartnett, J. Harton, T. Hasegawa, C. Hasnip, R. Hatcher, K. W. Hatfield, A. Hatzikoutelis, C. Hayes, K. Hayrapetyan, J. Hays, E. Hazen, M. He, A. Heavey, K. M. Heeger, J. Heise, S. Henry, M. A. Hernandez Morquecho, K. Herner, J. Hewes, C. Hilgenberg, T. Hill, S. J. Hillier, A. Himmel, E. Hinkle, L. R. Hirsch, J. Ho, J. Hoff, A. Holin, E. Hoppe, G. A. Horton-Smith, M. Hostert, A. Hourlier, B. Howard, R. Howell, J. Hoyos, I. Hristova, M. S. Hronek, J. Huang, Z. Hulcher, G. Iles, N. Ilic, A. M. Iliescu, R. Illingworth, G. Ingratta, A. Ioannisian, B. Irwin, L. Isenhower, R. Itay, C. M. Jackson, V. Jain, E. James, W. Jang, B. Jargowsky, F. Jediny, D. Jena, Y. S. Jeong, C. Jesús-Valls, X. Ji, L. Jiang, S. Jiménez, A. Jipa, R. Johnson, W. Johnson, N. Johnston, B. Jones, S. Jones, M. Judah, C. K. Jung, T. Junk, Y. Jwa, M. Kabirnezhad, A. Kaboth, I. Kadenko, I. Kakorin, A. Kalitkina, D. Kalra, F. Kamiya, N. Kaneshige, D. M. Kaplan, G. Karagiorgi, G. Karaman, A. Karcher, M. Karolak, Y. Karyotakis, S. Kasai, S. P. Kasetti, L. Kashur, N. Kazaryan, E. Kearns, P. Keener, K. J. Kelly, E. Kemp, O. Kemularia, W. Ketchum, S. H. Kettell, M. Khabibullin, A. Khotjantsev, A. Khvedelidze, D. Kim, B. King, B. Kirby, M. Kirby, J. Klein, A. Klustova, T. Kobilarcik, K. Koehler, L. W. Koerner, D. H. Koh, S. Kohn, P. P. Koller, L. Kolupaeva, D. Korablev, M. Kordosky, T. Kosc, U. Kose, V. A. Kostelecký, K. Kothekar, R. Kralik, L. Kreczko, F. Krennrich, I. Kreslo, W. Kropp, T. Kroupova, S. Kubota, Y. Kudenko, V. A. Kudryavtsev, S. Kulagin, J. Kumar, P. Kumar, P. Kunze, N. Kurita, C. Kuruppu, V. Kus, T. Kutter, J. Kvasnicka, D. Kwak, A. Lambert, B. Land, C. E. Lane, K. Lang, T. Langford, M. Langstaff, J. Larkin, P. Lasorak, D. Last, A. Laundrie, G. Laurenti, A. Lawrence, I. Lazanu, R. LaZur, M. Lazzaroni, T. Le, S. Leardini, J. Learned, P. LeBrun, T. LeCompte, C. Lee, S. Y. Lee, G. Lehmann Miotto, R. Lehnert, M. A. Leigui de Oliveira, M. Leitner, L. M. Lepin, S. W. Li, Y. Li, H. Liao, C. S. Lin, Q. Lin, S. Lin, R. A. Lineros, J. Ling, A. Lister, B. R. Littlejohn, J. Liu, Y. Liu, S. Lockwitz, T. Loew, M. Lokajicek, I. Lomidze, K. Long, T. Lord, J. M. LoSecco, W. C. Louis, X.-G. Lu, K. B. Luk, B. Lunday, X. Luo, E. Luppi, T. Lux, V. P. Luzio, J. Maalmi, D. MacFarlane, A. A. Machado, P. Machado, C. T. Macias, J. R. Macier, A. Maddalena, A. Madera, P. Madigan, S. Magill, K. Mahn, A. Maio, A. Major, J. A. Maloney, G. Mandrioli, R. C. Mandujano, J. Maneira, L. Manenti, S. Manly, A. Mann, K. Manolopoulos, M. Manrique Plata, V. N. Manyam, L. Manzanillas, M. Marchan, A. Marchionni, W. Marciano, D. Marfatia, C. Mariani, J. Maricic, R. Marie, F. Marinho, A. D. Marino, D. Marsden, M. Marshak, C. Marshall, J. Marshall, J. Marteau, J. Martín-Albo, N. Martinez, D. A. Martinez Caicedo, P. Martínez Miravé, S. Martynenko, V. Mascagna, K. Mason, A. Mastbaum, F. Matichard, S. Matsuno, J. Matthews, C. Mauger, N. Mauri, K. Mavrokoridis, I. Mawby, R. Mazza, A. Mazzacane, E. Mazzucato, T. McAskill, E. McCluskey, N. McConkey, K. S. McFarland, C. McGrew, A. McNab, A. Mefodiev, P. Mehta, P. Melas, O. Mena, H. Mendez, P. Mendez, D. P. Méndez, A. Menegolli, G. Meng, M. D. Messier, W. Metcalf, T. Mettler, M. Mewes, H. Meyer, T. Miao, G. Michna, T. Miedema, V. Mikola, R. Milincic, G. Miller, W. Miller, J. Mills, O. Mineev, A. Minotti, O. G. Miranda, S. Miryala, C. S. Mishra, S. R. Mishra, A. Mislivec, M. Mitchell, D. Mladenov, I. Mocioiu, K. Moffat, N. Moggi, R. Mohanta, T. A. Mohayai, N. Mokhov, J. Molina, L. Molina Bueno, E. Montagna, A. Montanari, C. Montanari, D. Montanari, L. M. Montañno Zetina, S. H. Moon, M. Mooney, A. F. Moor, D. Moreno, D. Moretti, C. Morris, C. Mossey, M. Mote, E. Motuk, C. A. Moura, J. Mousseau, G. Mouster, W. Mu, L. Mualem, J. Mueller, M. Muether, S. Mufson, F. Muheim, A. Muir, M. Mulhearn, D. Munford, H. Muramatsu, S. Murphy, J. Musser, J. Nachtman, S. Nagu, M. Nalbandyan, R. Nandakumar, D. Naples, S. Narita, A. Nath, A. Navrer-Agasson, N. Nayak, M. Nebot-Guinot, K. Negishi, J. K. Nelson, J. Nesbit, M. Nessi, D. Newbold, M. Newcomer, H. Newton, R. Nichol, F. Nicolas-Arnaldos, A. Nikolica, E. Niner, K. Nishimura, A. Norman, A. Norrick, R. Northrop, P. Novella, J. A. Nowak, M. Oberling, J. Ochoa-Ricoux, A. Olivier, A. Olshevskiy, Y. Onel, Y. Onishchuk, J. Ott, L. Pagani, G. Palacio, O. Palamara, S. Palestini, J. M. Paley, M. Pallavicini, C. Palomares, W. Panduro Vazquez, E. Pantic, V. Paolone, V. Papadimitriou, R. Papaleo, A. Papanestis, S. Paramesvaran, S. Parke, E. Parozzi, Z. Parsa, M. Parvu, S. Pascoli, L. Pasqualini, J. Pasternak, J. Pater, C. Patrick, L. Patrizii, R. B. Patterson, S. J. Patton, T. Patzak, A. Paudel, B. Paulos, L. Paulucci, Z. Pavlovic, G. Pawloski, D. Payne, V. Pec, S. J. M. Peeters, A. Pena Perez, E. Pennacchio, A. Penzo, O. L. G. Peres, J. Perry, D. Pershey, G. Pessina, G. Petrillo, C. Petta, R. Petti, V. Pia, F. Piastra, L. Pickering, F. Pietropaolo, V. L. Pimentel, G. Pinaroli, K. Plows, R. Plunkett, R. Poling, F. Pompa, X. Pons, N. Poonthottathil, F. Poppi, S. Pordes, J. Porter, M. Potekhin, R. Potenza, B. V. K. S. Potukuchi, J. Pozimski, M. Pozzato, S. Prakash, T. Prakash, M. Prest, S. Prince, F. Psihas, D. Pugnere, X. Qian, J. L. Raaf, V. Radeka, J. Rademacker, B. Radics, A. Rafique, E. Raguzin, M. Rai, M. Rajaoalisoa, I. Rakhno, A. Rakotonandrasana, L. Rakotondravohitra, R. Rameika, M. A. Ramirez Delgado, B. Ramson, A. Rappoldi, G. Raselli, P. Ratoff, S. Raut, R. F. Razakamiandra, E. M. Rea, J. S. Real, B. Rebel, R. Rechenmacher, M. Reggiani-Guzzo, J. Reichenbacher, S. D. Reitzner, H. Rejeb Sfar, A. Renshaw, S. Rescia, F. Resnati, M. Ribas, S. Riboldi, C. Riccio, G. Riccobene, L. C. J. Rice, J. S. Ricol, A. Rigamonti, Y. Rigaut, E. V. Rincón, H. Ritchie-Yates, D. Rivera, A. Robert, L. Rochester, M. Roda, P. Rodrigues, M. J. Rodriguez Alonso, E. Rodriguez Bonilla, J. Rodriguez Rondon, S. Rosauro-Alcaraz, M. Rosenberg, P. Rosier, B. Roskovec, M. Rossella, M. Rossi, J. Rout, P. Roy, A. Rubbia, C. Rubbia, B. Russell, D. Ruterbories, A. Rybnikov, A. Saa-Hernandez, R. Saakyan, S. Sacerdoti, T. Safford, N. Sahu, K. Sakashita, P. Sala, N. Samios, O. Samoylov, M. C. Sanchez, V. Sandberg, D. A. Sanders, D. Sankey, S. Santana, M. Santos-Maldonado, N. Saoulidou, P. Sapienza, C. Sarasty, I. Sarcevic, G. Savage, V. Savinov, A. Scaramelli, A. Scarff, A. Scarpelli, T. Schefke, H. Schellman, S. Schifano, P. Schlabach, D. Schmitz, A. W. Schneider, K. Scholberg, A. Schukraft, E. Segreto, A. Selyunin, C. R. Senise, J. Sensenig, A. Sergi, D. Sgalaberna, M. H. Shaevitz, S. Shafaq, F. Shaker, M. Shamma, R. Sharankova, H. R. Sharma, R. Sharma, R. K. Sharma, T. Shaw, K. Shchablo, C. Shepherd-Themistocleous, A. Sheshukov, S. Shin, I. Shoemaker, D. Shooltz, R. Shrock, H. Siegel, L. Simard, J. Sinclair, G. Sinev, J. Singh, L. Singh, P. Singh, V. Singh, R. Sipos, F. W. Sippach, G. Sirri, A. Sitraka, K. Siyeon, K. Skarpaas, A. Smith, E. Smith, P. Smith, J. Smolik, M. Smy, E. Snider, P. Snopok, D. Snowden-Ifft, M. Soares Nunes, H. Sobel, M. Soderberg, S. Sokolov, C. J. Solano Salinas, S. Söldner-Rembold, S. R. Soleti, N. Solomey, V. Solovov, W. E. Sondheim, M. Sorel, A. Sotnikov, J. Soto-Oton, F. A. Soto Ugaldi, A. Sousa, K. Soustruznik, F. Spagliardi, M. Spanu, J. Spitz, N. J. C. Spooner, K. Spurgeon, M. Stancari, L. Stanco, C. Stanford, R. Stein, H. M. Steiner, A. F. Steklain Lisbôa, J. Stewart, B. Stillwell, J. Stock, F. Stocker, T. Stokes, M. Strait, T. Strauss, L. Strigari, A. Stuart, J. G. Suarez, J. M. Suárez Sunción, H. Sullivan, D. Summers, A. Surdo, V. Susic, L. Suter, C. M. Sutera, R. Svoboda, B. Szczerbinska, A. M. Szelc, H. Tanaka, S. Tang, A. Tapia, B. Tapia Oregui, A. Tapper, S. Tariq, E. Tarpara, N. Tata, E. Tatar, R. Tayloe, A. M. Teklu, P. Tennessen, M. Tenti, K. Terao, C. A. Ternes, F. Terranova, G. Testera, T. Thakore, A. Thea, J. L. Thompson, C. Thorn, S. C. Timm, V. Tishchenko, L. Tomassetti, A. Tonazzo, D. Torbunov, M. Torti, M. Tortola, F. Tortorici, N. Tosi, D. Totani, M. Toups, C. Touramanis, R. Travaglini, J. Trevor, S. Trilov, W. H. Trzaska, Y. Tsai, Y.-T. Tsai, Z. Tsamalaidze, K. V. Tsang, N. Tsverava, S. Tufanli, C. Tull, E. Tyley, M. Tzanov, L. Uboldi, M. A. Uchida, J. Urheim, T. Usher, S. Uzunyan, M. R. Vagins, P. Vahle, S. Valder, G. D. A. Valdiviesso, E. Valencia, R. Valentim, Z. Vallari, E. Vallazza, J. W. F. Valle, S. Vallecorsa, R. Van Berg, R. G. Van de Water, D. Vanegas Forero, D. Vannerom, F. Varanini, D. Vargas Oliva, G. Varner, J. Vasel, S. Vasina, G. Vasseur, N. Vaughan, K. Vaziri, S. Ventura, A. Verdugo, S. Vergani, M. A. Vermeulen, M. Verzocchi, M. Vicenzi, H. Vieira de Souza, C. Vignoli, C. Vilela, B. Viren, T. Vrba, T. Wachala, A. V. Waldron, M. Wallbank, C. Wallis, H. Wang, J. Wang, L. Wang, M. H. L. S. Wang, X. Wang, Y. Wang, K. Warburton, D. Warner, M. O. Wascko, D. Waters, A. Watson, K. Wawrowska, P. Weatherly, A. Weber, M. Weber, H. Wei, A. Weinstein, D. Wenman, M. Wetstein, A. White, L. H. Whitehead, D. Whittington, M. J. Wilking, A. Wilkinson, C. Wilkinson, Z. Williams, F. Wilson, R. J. Wilson, W. Wisniewski, J. Wolcott, T. Wongjirad, A. Wood, K. Wood, E. Worcester, M. Worcester, K. Wresilo, C. Wret, W. Wu, Y. Xiao, F. Xie, B. Yaeggy, E. Yandel, G. Yang, K. Yang, T. Yang, A. Yankelevich, N. Yershov, K. Yonehara, Y. S. Yoon, T. Young, B. Yu, H. Yu, J. Yu, Y. Yu, W. Yuan, R. Zaki, J. Zalesak, L. Zambelli, B. Zamorano, A. Zani, L. Zazueta, G. P. Zeller, J. Zennamo, K. Zeug, C. Zhang, S. Zhang, Y. Zhang, M. Zhao, E. Zhivun, G. Zhu, E. D. Zimmerman, S. Zucchelli, J. Zuklin, V. Zutshi, R. Zwaska, and DUNE Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6 $$\times $$ × 6 $$\times $$ × 6 m $$^3$$ 3 liquid argon time-projection-chamber (LArTPC) that recorded cosmic-muon data at the CERN Neutrino Platform in 2019–2020 as a prototype of the DUNE Far Detector. Charged particles propagating through the LArTPC produce ionization and scintillation light. The scintillation light signal in these detectors can provide the trigger for non-beam events. In addition, it adds precise timing capabilities and improves the calorimetry measurements. In ProtoDUNE-DP, scintillation and electroluminescence light produced by cosmic muons in the LArTPC is collected by photomultiplier tubes placed up to 7 m away from the ionizing track. In this paper, the ProtoDUNE-DP photon detection system performance is evaluated with a particular focus on the different wavelength shifters, such as PEN and TPB, and the use of Xe-doped LAr, considering its future use in giant LArTPCs. The scintillation light production and propagation processes are analyzed and a comparison of simulation to data is performed, improving understanding of the liquid argon properties.

Published
2022
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170. Spatio-temporal dynamics of aerosol distribution in an urban environment recorded in situ by means of a bike based monitoring system

Author

Stefan Norra, Junwei Song, Reiner Gebhardt, Jonas Bauer, Magdalena Broß, Marco Fuchs, Theresa Huber, Dennis Mack, and Harald Saathoff

Subjects
mobile, bicycle, aerosol, measurement platform, spatial pattern, urban pollution, Environmental sciences, GE1-350
Abstract

Aerosol pollution in urban areas is highly variable due to numerous single emission sources such as automobiles, industrial and commercial activities as well as domestic heating, but also due to complex building structures redirecting air mass flows, producing leeward and windward turbulences and resuspension effects. In this publication, it is shown that one or even few aerosol monitoring sites are not able to reflect these complex patterns. In summer 2019, aerosol pollution was recorded in high spatial resolution during six night and daytime tours with a mobile sensor platform on a trailer pulled by a bicycle. Particle mass loadings showed a high variability with PM10 values ranging from 1.3 to 221 μg m−3 and PM2.5 values from 0.7 to 69.0 μg m−3. Geostatistics were used to calculate respective models of the spatial distributions of PM2.5 and PM10. The resulting maps depict the variability of aerosol concentrations within the urban space. These spatial distribution models delineate the distributions without cutting out the built-up structures. Elsewise, the overall spatial patterns do not become visible because of being sharply interrupted by those cutouts in the resulting maps. Thus, the spatial maps allow to identify most affected urban areas and are not restricted to the street space. Furthermore, this method provides an insight to potentially affected areas, and thus can be used to develop counter measures. It is evident that the spatial aerosol patterns cannot be directly derived from the main wind direction, but result far more from an interplay between main wind direction, built-up patterns and distribution of pollution sources. Not all pollution sources are directly obvious and more research has to be carried out to explain the micro-scale variations of spatial aerosol distribution patterns. In addition, since aerosol load in the atmosphere is a severe issue for health and wellbeing of city residents more attention has to be paid to these local inhomogeneities.

Published
2023
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175. RF system for the MICE demonstration of ionization cooling

Author

Ronald, K., Whyte, C. G., Dick, A. J., Young, A. R., Li, D., DeMello, A. J., Lambert, A. R., Luo, T., Anderson, T., Bowring, D., Bross, A., Moretti, A., Pasquinelli, R., Peterson, D., Popovic, M., Schultz, R., Volk, J., Torun, Y., Hanlet, P., Freemire, B., Moss, A., Dumbell, K., Grant, A., White, C., Griffiths, S., Stanley, T., Anderson, R., Alsari, S., Long, K., Kurup, A., Summers, D., and Smith, P. J.

Subjects
Physics - Accelerator Physics
Abstract

Muon accelerators offer an attractive option for a range of future particle physics experiments. They can enable high energy (TeV+) high energy lepton colliders whilst mitigating the difficulty of synchrotron losses, and can provide intense beams of neutrinos for fundamental physics experiments investigating the physics of flavor. The method of production of muon beams results in high beam emittance which must be reduced for efficient acceleration. Conventional emittance control schemes take too long, given the very short (2.2 microsecond) rest lifetime of the muon. Ionisation cooling offers a much faster approach to reducing particle emittance, and the international MICE collaboration aims to demonstrate this technique for the first time. This paper will present the MICE RF system and its role in the context of the overall experiment., Comment: 2 pp

Published
2017

176. Baby MIND: A magnetized segmented neutrino detector for the WAGASCI experiment

Author

Antonova, M., Asfandiyarov, R., Bayes, R., Benoit, P., Blondel, A., Bogomilov, M., Bross, A., Cadoux, F., Cervera, A., Chikuma, N., Dudarev, A., Ekelöf, T., Favre, Y., Fedotov, S., Hallsjö, S-P., Izmaylov, A., Karadzhov, Y., Khabibullin, M., Khotyantsev, A., Kleymenova, A., Koga, T., Kostin, A., Kudenko, Y., Likhacheva, V., Martinez, B., Matev, R., Medvedeva, M., Mefodiev, A., Minamino, A., Mineev, O., Nessi, M., Nicola, L., Noah, E., Ovsiannikova, T., Da Silva, H. Pais, Parsa, S., Rayner, M., Rolando, G., Shaykhiev, A., Simion, P., Soler, F. J. P., Suvorov, S., Tsenov, R., Kate, H. Ten, Vankova-Kirilova, G., and Yershov, N.

Subjects
Physics - Instrumentation and Detectors
Abstract

T2K (Tokai-to-Kamioka) is a long-baseline neutrino experiment in Japan designed to study various parameters of neutrino oscillations. A near detector complex (ND280) is located 280~m downstream of the production target and measures neutrino beam parameters before any oscillations occur. ND280's measurements are used to predict the number and spectra of neutrinos in the Super-Kamiokande detector at the distance of 295~km. The difference in the target material between the far (water) and near (scintillator, hydrocarbon) detectors leads to the main non-cancelling systematic uncertainty for the oscillation analysis. In order to reduce this uncertainty a new WAter-Grid-And-SCintillator detector (WAGASCI) has been developed. A magnetized iron neutrino detector (Baby MIND) will be used to measure momentum and charge identification of the outgoing muons from charged current interactions. The Baby MIND modules are composed of magnetized iron plates and long plastic scintillator bars read out at the both ends with wavelength shifting fibers and silicon photomultipliers. The front-end electronics board has been developed to perform the readout and digitization of the signals from the scintillator bars. Detector elements were tested with cosmic rays and in the PS beam at CERN. The obtained results are presented in this paper., Comment: In new version: modified both plots of Fig.1 and added one sentence in the introduction part explaining Baby MIND role in WAGASCI experiment, added information for the affiliations

Published
2017
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177. Baby MIND Experiment Construction Status

Author

Antonova, M., Asfandiyarov, R., Bayes, R, Benoit, P., Blondel, A., Bogomilov, M., Bross, A., Cadoux, F., Cervera, A., Chikuma, N., Dudarev, A., Ekelöf, T., Favre, Y., Fedotov, S., Hallsjö, S-P., Izmaylov, A., Karadzhov, Y., Khabibullin, M., Khotyantsev, A., Kleymenova, A., Koga, T., Kostin, A., Kudenko, Y., Likhacheva, V., Martinez, B., Matev, R., Medvedeva, M., Mefodiev, A., Minamino, A., Mineev, O., Nessi, M., Nicola, L., Noah, E., Ovsiannikova, T., Da Silva, H. Pais, Parsa, S., Rayner, M., Rolando, G., Shaykhiev, A, Simion, P., Soler, F. J. P., Suvorov, S., Tsenov, R., Kate, H. Ten, Vankova-Kirilova, G., and Yershov, N.

Subjects
Physics - Instrumentation and Detectors
Abstract

Baby MIND is a magnetized iron neutrino detector, with novel design features, and is planned to serve as a downstream magnetized muon spectrometer for the WAGASCI experiment on the T2K neutrino beam line in Japan. One of the main goals of this experiment is to reduce systematic uncertainties relevant to CP-violation searches, by measuring the neutrino contamination in the anti-neutrino beam mode of T2K. Baby MIND is currently being constructed at CERN, and is planned to be operational in Japan in October 2017., Comment: Poster presented at NuPhys2016 (London, 12-14 December 2016). 4 pages, LaTeX, 7 figures

Published
2017

178. A FODO racetrack ring design and optimization for nuSTORM

Author

Liu, Ao, Bross, Alan, and Neuffer, David

Subjects
Physics - Accelerator Physics
Abstract

The goal of nuSTORM is to provide well-defined neutrino beams for precise measurements of neutrino cross-sections and oscillations. The nuSTORM decay ring is a compact racetrack storage ring with a circumference of ~480 m that incorporates large aperture (60 cm diameter) magnets. There are many challenges in the design. In order to incorporate the Orbit Combination Section (OCS), used for injecting the pion beam into the ring, a dispersion suppressor is needed adjacent to the OCS. Concurrently, in order to maximize the number of useful muon decays, strong bending dipoles are needed in the arcs to minimize the arc length. These dipoles create strong chromatic effects, which need to be corrected by nonlinear sextupole elements in the ring. In this paper, a FODO racetrack ring design and its optimization using sextupolar fields via both a Genetic Algorithm (GA) and a Simulated Annealing (SA) algorithm will be discussed.

Published
2017
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179. Design and expected performance of the MICE demonstration of ionization cooling

Author

MICE Collaboration, Bogomilov, M., Tsenov, R., Vankova-Kirilova, G., Song, Y., Tang, J., Li, Z., Bertoni, R., Bonesini, M., Chignoli, F., Mazza, R., Palladino, V., de Bari, A., Cecchet, G., Orestano, D., Tortora, L., Kuno, Y., Ishimoto, S., Filthaut, F., Jokovic, D., Maletic, D., Savic, M., Hansen, O. M., Ramberger, S., Vretenar, M., Asfandiyarov, R., Blondel, A., Drielsma, F., Karadzhov, Y., Charnley, G., Collomb, N., Gallagher, A., Grant, A., Griffiths, S., Hartnett, T., Martlew, B., Moss, A., Muir, A., Mullacrane, I., Oates, A., Owens, P., Stokes, G., Tucker, M., Warburton, P., White, C., Adams, D., Anderson, R. J., Barclay, P., Bayliss, V., Boehm, J., Bradshaw, T. W., Courthold, M., Dumbell, K., Francis, V., Fry, L., Hayler, T., Hills, M., Lintern, A., Macwaters, C., Nichols, A., Preece, R., Ricciardi, S., Rogers, C., Stanley, T., Tarrant, J., Wilson, A., Watson, S., Bayes, R., Nugent, J. C., Soler, F. J. P., Gamet, R., Barber, G., Blackmore, V. J., Colling, D., Dobbs, A., Dornan, P., Hunt, C., Kurup, A., Lagrange, J-B., Long, K., Martyniak, J., Middleton, S., Pasternak, J., Uchida, M. A., Cobb, J. H., Lau, W., Booth, C. N., Hodgson, P., Langlands, J., Overton, E., Robinson, M., Smith, P. J., Wilbur, S., Dick, A. J., Ronald, K., Whyte, C. G., Young, A. R., Boyd, S., Franchini, P., Greis, J. R., Pidcott, C., Taylor, I., Gardener, R. B. S., Kyberd, P., Nebrensky, J. J., Palmer, M., Witte, H., Bross, A. D., Bowring, D., Liu, A., Neuffer, D., Popovic, M., Rubinov, P., DeMello, A., Gourlay, S., Li, D., Prestemon, S., Virostek, S., Freemire, B., Hanlet, P., Kaplan, D. M., Mohayai, T. A., Rajaram, D., Snopok, P., Suezaki, V., Torun, Y., Onel, Y., Cremaldi, L. M., Sanders, D. A., Summers, D. J., Hanson, G. G., and Heidt, C.

Subjects
Physics - Accelerator Physics
Abstract

Muon beams of low emittance provide the basis for the intense, well-characterised neutrino beams necessary to elucidate the physics of flavour at a neutrino factory and to provide lepton-antilepton collisions at energies of up to several TeV at a muon collider. The international Muon Ionization Cooling Experiment (MICE) aims to demonstrate ionization cooling, the technique by which it is proposed to reduce the phase-space volume occupied by the muon beam at such facilities. In an ionization-cooling channel, the muon beam passes through a material in which it loses energy. The energy lost is then replaced using RF cavities. The combined effect of energy loss and re-acceleration is to reduce the transverse emittance of the beam (transverse cooling). A major revision of the scope of the project was carried out over the summer of 2014. The revised experiment can deliver a demonstration of ionization cooling. The design of the cooling demonstration experiment will be described together with its predicted cooling performance., Comment: 21 pages, 10 figures

Published
2017
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180. Transportation Perspectives of Young Adults With Intellectual and Developmental Disabilities, Parents, and Service Providers.

Author

Ann Bross, Leslie, Fredrick, Darcy, and Kwiatek, Stephen

Subjects
YOUNG adults, INTELLECTUAL disabilities, DEVELOPMENTAL disabilities, COMMUNITY involvement, SEMI-structured interviews
Abstract

Young adults with intellectual and developmental disabilities (IDD) are vulnerable to transportation challenges which can contribute to a lack of community engagement. This article describes findings from a qualitative study in which we conducted one time, semistructured interviews with nine individuals with IDD (ages 18–25) and their parents/guardians in dyads. We also interviewed 10 adult service and local agency providers to incorporate different perspectives. Major themes included family factors, community structure, and systems challenges as barriers that impacted the transportation experiences of young adults with IDD and their families. We provide implications for transition-related professionals and suggestions for future research and policy focused on transportation. [ABSTRACT FROM AUTHOR]

Published
2024
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182. Adding to the Evidence Base: Effects of I-Connect in a Secondary Special Education Rural Classroom.

Author

Kester, Jason L. and Bross, Leslie Ann

Abstract

The purpose of this study was to examine the effects of a technology-based self-monitoring application, I-Connect, to enhance the on-task behavior of five secondary students (ages 15–16) with autism spectrum disorder, intellectual disability, and specific learning disability during Biology instruction in a rural special education classroom. We used an A-B-A-B withdrawal design with a generalization condition. The primary dependent variable was percent of intervals with on-task behavior as measured by momentary time sampling procedures. Results indicated overall higher levels of on-task behavior for all students when using I-Connect to monitor their behavior. However, there were also high percentages of overlapping data, and student satisfaction with the application was relatively low. Students used I-Connect in an employability seminar offered at their school as a means to generalize to a different setting. We provide implications for practice in rural settings and suggestions for future research related to I-Connect. We also provide recommendations for enhancing the social validity of technology-based self-monitoring for secondary students with disabilities. [ABSTRACT FROM AUTHOR]

Published
2024
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183. Mass testing of SiPMs for the CMVD at IICHEP

Author

Mamta Jangra, Raj Bhupen, Gobinda Majumder, Kiran Gothe, Mandar Saraf, Nandkishor Parmar, Bheesette Satyanarayana, Ravindra R. Shinde, Shobha K. Rao, Suresh S. Upadhya, Vivek M. Datar, Douglas A. Glenzinski, Alan Bross, Anna Pla-Dalmau, Vishnu V. Zutshi, Robert Craig Group, Edmond Craig Dukes

Subjects
Physics, QC1-999
Abstract

A Cosmic Muon Veto Detector (CMVD) is being built around the mini-Iron Calorimeter (mini-ICAL) detector at the transit campus of the India based Neutrino Observatory, Madurai. The CMV detector will be made using extruded plastic scintillators with embedded wavelength shifting (WLS) fibres which propagate re-emitted photons of longer wavelengths to silicon photo-multipliers (SiPMs). The SiPMs detect these scintillation photons, producing electronic signals. The design goal for the cosmic muon veto efficiency of the CMV is $>$99.99% and fake veto rate less than 10$^{-5}$. A testing system was developed, using an LED driver, to measure the noise rate and gain of each SiPM, and thus determine its overvoltage ($V_{ov}$). This paper describes the test results and the analysed characteristics of about 3.5k SiPMs.

Published
2023
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192. Effects of Video Modeling for Young Adults with Autism in Community Employment Settings

Author

Bross, Leslie Ann, Travers, Jason C., Wills, Howard P., Huffman, Jonathan M., Watson, Emma K., Morningstar, Mary E., and Boyd, Brian A.

Abstract

This single case design study evaluated the effects of a video modeling (VM) intervention on the customer service skills of five young adults with autism spectrum disorder (ASD). Verbalization of greeting, service, and closing phrases contextualized to community employment settings were the target behaviors. A systematic approach to visual analysis indicated the presence of a functional relation for all participants. Coworkers, job coaches, and supervisors successfully applied the VM intervention during the generalization condition. Maintenance probes conducted at 2 and 4 weeks indicated that most customer service skills were maintained. Results indicated VM was also effective in enhancing the quality of interactions with customers. Implications for research and practice related to the competitive employment of young adults with ASD are discussed.

Published
2020
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193. Teacher-Delivered Strategies to Increase Students' Opportunities to Respond: A Systematic Methodological Review

Author

Common, Eric Alan, Lane, Kathleen Lynne, Cantwell, Emily D., Brunsting, Nelson C., Oakes, Wendy Peia, Germer, Kathryn Ann, and Bross, Leslie Ann

Abstract

We conducted this systematic review to map the literature and classify the evidence-based status of teacher-directed strategies to increase students' opportunities to respond (OTR) during whole-group instruction across the K-12 continuum. Specifically, we conducted this review to determine whether OTR could be classified as an evidence-based practice according to Council for Exceptional Children's "Standards for Evidence-Based Practices in Special Education." We examined the extent to which 21 included studies addressed quality indicators and evidence-based practice standards using a modified, weighted criterion for methodologically sound studies. Three studies met all eight quality indicators and 11 studies met or exceeded 80% of quality indicators following a weighted criterion to define methodologically sound studies. Results indicated teacher-directed OTR strategy of response cards in K-12 school settings to be a potentially evidence-based practice. Educational implications, limitations, and future directions are discussed.

Published
2020
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194. 'How is your thesis going?'-Ph.D. students' perspectives on mental health and stress in academia.

Author

Julian Friedrich, Anna Bareis, Moritz Bross, Zoé Bürger, Álvaro Cortés Rodríguez, Nina Effenberger, Markus Kleinhansl, Fabienne Kremer, and Cornelius Schröder

Subjects
Medicine, Science
Abstract

Mental health issues among Ph.D. students are prevalent and on the rise, with multiple studies showing that Ph.D. students are more likely to experience symptoms of mental health-related issues than the general population. However, the data is still sparse. This study aims to investigate the mental health of 589 Ph.D. students at a public university in Germany using a mixed quantitative and qualitative approach. We administered a web-based self-report questionnaire to gather data on the mental health status, investigated mental illnesses such as depression and anxiety, and potential areas for improvement of the mental health and well-being of Ph.D. students. Our results revealed that one-third of the participants were above the cut-off for depression and that factors such as perceived stress and self-doubt were prominent predictors of the mental health status of Ph.D. students. Additionally, we found job insecurity and low job satisfaction to be predictors of stress and anxiety. Many participants in our study reported working more than full-time while being employed part-time. Importantly, deficient supervision was found to have a negative effect on Ph.D. students' mental health. The study's results are in line with those of earlier investigations of mental health in academia, which likewise reveal significant levels of depression and anxiety among Ph.D. students. Overall, the findings provide a greater knowledge of the underlying reasons and potential interventions required for advancing the mental health problems experienced by Ph.D. students. The results of this research can guide the development of effective strategies to support the mental health of Ph.D. students.

Published
2023
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195. Expertise determines frequency and accuracy of contributions in sequential collaboration

Author

Maren Mayer, Marcel Broß, and Daniel W. Heck

Subjects
wisdom of crowds, group decision-making, mass collaboration, team work, Social Sciences, Psychology, BF1-990
Abstract

Many collaborative online projects such as Wikipedia and OpenStreetMap organize collaboration among their contributors sequentially. In sequential collaboration, one contributor creates an entry which is then consecutively encountered by other contributors who decide whether to adjust or maintain the presented entry. For numeric and geographical judgments, sequential collaboration yields improved judgments over the course of a sequential chain and results in accurate final estimates. We hypothesize that these benefits emerge since contributors adjust entries according to their expertise, implying that judgments of experts have a larger impact compared with those of novices. In three preregistered studies, we measured and manipulated expertise to investigate whether expertise leads to higher change probabilities and larger improvements in judgment accuracy. Moreover, we tested whether expertise results in an increase in accuracy over the course of a sequential chain. As expected, experts adjusted entries more frequently, made larger improvements, and contributed more to the final estimates of sequential chains. Overall, our findings suggest that the high accuracy of sequential collaboration is due to an implicit weighting of judgments by expertise.

Published
2023
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196. A community-partnered approach for diversity in COVID-19 vaccine clinical trials

Author

Yelba Castellon-Lopez, Raphael Landovitz, Ejiro Ntekume, Courtney Porter, Rachelle Bross, Robin Hilder, Aziza Lucas-Wright, Eric S. Daar, Pedro Chavez, Christopher Blades, Savanna Carson, D’Ann Morris, Stefanie Vassar, Alejandra Casillas, and Arleen Brown

Subjects
COVID-19, community engagement, research subject recruitment, vaccine trials, health equity, Medicine
Abstract

Abstract Introduction: Communities of color have faced disproportionate morbidity and mortality from COVID-19, coupled with historical underrepresentation in US clinical trials, creating challenges for equitable participation in developing and testing a safe and effective COVID-19 vaccine. Methods: To increase diversity, including racial and ethnic representation, in local Los Angeles County NIH-sponsored Phase 3 SARS-CoV-2 vaccine clinical trials, we used deliberative community engagement approaches to form a Community Consultant Panel (CCP) that partnered with trial research teams. Thirteen members were recruited, including expertise from essential workers, community-based and faith-based organizations, or leaders from racial and ethnic minority communities. Results: Working closely with local investigators for the vaccine studies, the CCP provided critical insight on best practices for community trust building, clinical trial participation, and reliable information dissemination regarding COVID-19 vaccines. Modifying recruitment, outreach, and trial protocols led to majority–minority participants (55%–78%) in each of the three vaccine clinical trials. CCP’s input led to cultural tailoring of recruitment materials, changes in recruitment messaging, and supportive services to improve trial accessibility and acceptability (transportation, protocols for cultural competency, and support linkages to care in case of an adverse event). Barriers to clinical trial participation unable to be resolved included childcare, requests for after-hours appointment availability, and mobile locations for trial visits. Conclusion: Using deliberative community engagement can provide critical and timely insight into the community-centered barriers to COVID-19 vaccine trial participation, including addressing social determinants of health, trust, clinical trial literacy, structural barriers, and identifying trusted messenger and reliable sources of information.

Published
2023
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197. Video Modeling to Improve Customer Service Skills of an Employed Young Adult with Autism

Author

Bross, Leslie Ann, Travers, Jason C., Munandar, Vidya D., and Morningstar, Mary

Abstract

Providing evidence-based interventions in competitive employment settings is critical to improve employment outcomes for individuals with autism. This study used a multiple baseline across behaviors design to enhance the customer service skills of a young adult with autism employed as a cashier at a retail store. Results indicated the use of customer service phrases increased contingent on delivery of corresponding video models. Implications for employing young adults with autism in community-based settings are discussed.

Published
2019
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198. Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease

Author

Harlow, Kathryn E, Africa, Jonathan A, Wells, Alan, Belt, Patricia H, Behling, Cynthia A, Jain, Ajay K, Molleston, Jean P, Newton, Kimberly P, Rosenthal, Philip, Vos, Miriam B, Xanthakos, Stavra A, Lavine, Joel E, Schwimmer, Jeffrey B, Network, Nonalcoholic Steatohepatitis Clinical Research, Abrams, Stephanie H, Barlow, Sarah, Himes, Ryan, Krisnamurthy, Rajesh, Maldonado, Leanel, Mahabir, Rory, Carr, April, Bernstein, Kimberlee, Bramlage, Kristin, Cecil, Kim, DeVore, Stephanie, Kohli, Rohit, Lake, Kathleen, Podberesky, Daniel, Towbin, Alex, Behr, Gerald, Lefkowitch, Jay H, Mencin, Ali, Reynoso, Elena, Alazraki, Adina, Cleeton, Rebecca, Cordero, Maria, Hernandez, Albert, Karpen, Saul, Munos, Jessica Cruz, Raviele, Nicholas, Bozic, Molly, Cummings, Oscar W, Klipsch, Ann, Ragozzino, Emily, Sandrasegaran, Kumar, Subbarao, Girish, Walker, Laura, Kafka, Kimberly, Scheimann, Ann, Ito, Joy, Fishbein, Mark H, Mohammad, Saeed, Rigsby, Cynthia, Sharda, Lisa, Whitington, Peter F, Cattoor, Theresa, Derdoy, Jose, Freebersyser, Janet, King, Debra, Lai, Jinping, Osmack, Pat, Siegner, Joan, Stewart, Susan, Torretta, Susan, Wriston, Kristina, Baker, Susan S, Lopez-Graham, Diana, Williams, Sonja, Zhu, Lixin, Awai, Hannah, Bross, Craig, Collins, Jennifer, Durelle, Janis, Middleton, Michael, Paiz, Melissa, Sirlin, Claude, Ugalde-Nicalo, Patricia, Villarreal, Mariana Dominguez, Aouizerat, Bradley, Courtier, Jesse, Ferrell, Linda D, Feier, Natasha, Gill, Ryan, Langlois, Camille, Perito, Emily Rothbaum, Tsai, Patrika, Cooper, Kara, Horslen, Simon, Hsu, Evelyn, Murray, Karen, Otto, Randolph, Yeh, Matthew, Young, Melissa, Brunt, Elizabeth M, Fowler, Kathryn, Kleiner, David E, Brown, Sherry, Doo, Edward C, and Hoofnagle, Jay H

Subjects
Paediatrics, Biomedical and Clinical Sciences, Pediatric, Chronic Liver Disease and Cirrhosis, Cardiovascular, Health Disparities, Obesity, Minority Health, Prevention, Liver Disease, Digestive Diseases, Nutrition, 2.4 Surveillance and distribution, Metabolic and endocrine, Good Health and Well Being, Child, Cholesterol, LDL, Diet, Female, Humans, Hypercholesterolemia, Hypertriglyceridemia, Life Style, Longitudinal Studies, Male, Non-alcoholic Fatty Liver Disease, Triglycerides, Nonalcoholic Steatohepatitis Clinical Research Network, NAFLD, cardiovascular, diet, dyslipidemia, pediatric, statin, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Blood Institute guidelines.Study designThis multicenter, longitudinal cohort study included children with NAFLD enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Nonalcoholic Steatohepatitis Clinical Research Network. Fasting lipid profiles were obtained at diagnosis. Standardized dietary recommendations were provided. After 1 year, lipid profiles were repeated and interpreted according to National Heart, Lung, and Blood Institute Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction. Main outcomes were meeting criteria for clinically actionable dyslipidemia at baseline, and either achieving lipid goal at follow-up or meeting criteria for ongoing intervention.ResultsThere were 585 participants, with a mean age of 12.8 years. The prevalence of children warranting intervention for low-density lipoprotein cholesterol at baseline was 14%. After 1 year of recommended dietary changes, 51% achieved goal low-density lipoprotein cholesterol, 27% qualified for enhanced dietary and lifestyle modifications, and 22% met criteria for pharmacologic intervention. Elevated triglycerides were more prevalent, with 51% meeting criteria for intervention. At 1 year, 25% achieved goal triglycerides with diet and lifestyle changes, 38% met criteria for advanced dietary modifications, and 37% qualified for antihyperlipidemic medications.ConclusionsMore than one-half of children with NAFLD met intervention thresholds for dyslipidemia. Based on the burden of clinically relevant dyslipidemia, lipid screening in children with NAFLD is warranted. Clinicians caring for children with NAFLD should be familiar with lipid management.

Published
2018

199. Tevatron Run II combination of the effective leptonic electroweak mixing angle

Author

Aaltonen, T, Abazov, VM, Abbott, B, Acharya, BS, Adams, M, Adams, T, Agnew, JP, Alexeev, GD, Alkhazov, G, Alton, A, Amerio, S, Amidei, D, Anastassov, A, Annovi, A, Antos, J, Apollinari, G, Appel, JA, Arisawa, T, Artikov, A, Asaadi, J, Ashmanskas, W, Askew, A, Atkins, S, Auerbach, B, Augsten, K, Aurisano, A, Aushev, V, Aushev, Y, Avila, C, Azfar, F, Badaud, F, Badgett, W, Bae, T, Bagby, L, Baldin, B, Bandurin, DV, Banerjee, S, Barbaro-Galtieri, A, Barberis, E, Baringer, P, Barnes, VE, Barnett, BA, Barria, P, Bartlett, JF, Bartos, P, Bassler, U, Bauce, M, Bazterra, V, Bean, A, Bedeschi, F, Begalli, M, Behari, S, Bellantoni, L, Bellettini, G, Bellinger, J, Benjamin, D, Beretvas, A, Beri, SB, Bernardi, G, Bernhard, R, Bertram, I, Besançon, M, Beuselinck, R, Bhat, PC, Bhatia, S, Bhatnagar, V, Bhatti, A, Bland, KR, Blazey, G, Blessing, S, Bloom, K, Blumenfeld, B, Bocci, A, Bodek, A, Boehnlein, A, Boline, D, Boos, EE, Borissov, G, Bortoletto, D, Borysova, M, Boudreau, J, Boveia, A, Brandt, A, Brandt, O, Brigliadori, L, Brochmann, M, Brock, R, Bromberg, C, Bross, A, Brown, D, Brucken, E, Bu, XB, Budagov, J, Budd, HS, Buehler, M, Buescher, V, Bunichev, V, Burdin, S, Burkett, K, and Busetto, G

Subjects
hep-ex
Abstract

Drell-Yan lepton pairs produced in the process pp→â.,"+â.,"-+X through an intermediate γ∗/Z boson have an asymmetry in their angular distribution related to the spontaneous symmetry breaking of the electroweak force and the associated mixing of its neutral gauge bosons. The CDF and D0 experiments have measured the effective-leptonic electroweak mixing parameter sin2θefflept using electron and muon pairs selected from the full Tevatron proton-antiproton data sets collected in 2001-2011, corresponding to 9-10 fb-1 of integrated luminosity. The combination of these measurements yields the most precise result from hadron colliders, sin2θefflept=0.23148±0.00033. This result is consistent with, and approaches in precision, the best measurements from electron-positron colliders. The standard model inference of the on-shell electroweak mixing parameter sin2θW, or equivalently the W-boson mass MW, using the zfitter software package yields sin2θW=0.22324±0.00033 or equivalently, MW=80.367±0.017 GeV/c2.

Published
2018

200. In Children With Nonalcoholic Fatty Liver Disease, Zone 1 Steatosis Is Associated With Advanced Fibrosis

Author

Africa, Jonathan A, Behling, Cynthia A, Brunt, Elizabeth M, Zhang, Nan, Luo, Yunjun, Wells, Alan, Hou, Jiayi, Belt, Patricia H, Kohil, Rohit, Lavine, Joel E, Molleston, Jean P, Newton, Kimberly P, Whitington, Peter F, Schwimmer, Jeffrey B, Abrams, Stephanie H, Barlow, Sarah, Himes, Ryan, Krisnamurthy, Rajesh, Maldonado, Leanel, Mahabir, Rory, Carr, April, Bernstein, Kimberlee, Bramlage, Kristin, Cecil, Kim, DeVore, Stephanie, Kohli, Rohit, Lake, Kathleen, Podberesky, Daniel, Towbin, Alex, Xanthakos, Stavra, Behr, Gerald, Lefkowitch, Jay H, Mencin, Ali, Reynoso, Elena, Alazraki, Adina, Cleeton, Rebecca, Cordero, Maria, Hernandez, Albert, Karpen, Saul, Munos, Jessica Cruz, Raviele, Nicholas, Vos, Miriam, Bozic, Molly, Cummings, Oscar W, Klipsch, Ann, Ragozzino, Emily, Sandrasegaran, Kumar, Subbarao, Girish, Walker, Laura, Kafka, Kimberly, Scheimann, Ann, Ito, Joy, Fishbein, Mark H, Mohammad, Saeed, Rigsby, Cynthia, Sharda, Lisa, Cattoor, Theresa, Derdoy, Jose, Freebersyser, Janet, Jain, Ajay, King, Debra, Lai, Jinping, Osmack, Pat, Siegner, Joan, Stewart, Susan, Torretta, Susan, Wriston, Kristina, Baker, Susan S, Lopez–Graham, Diana, Williams, Sonja, Zhu, Lixin, Africa, Jonathan, Awai, Hannah, Behling, Cynthia, Bross, Craig, Collins, Jennifer, Durelle, Janis, Harlow, Kathryn, Middleton, Michael, Newton, Kimberly, Paiz, Melissa, Sirlin, Claude, Ugalde-Nicalo, Patricia, Villarreal, Mariana Dominguez, Aouizerat, Bradley, Courtier, Jesse, Ferrell, Linda D, Feier, Natasha, Gill, Ryan, Langlois, Camille, Perito, Emily Rothbaum, Rosenthal, Philip, Tsai, Patrika, Cooper, Kara, and Horslen, Simon

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Digestive Diseases, Hepatitis, Liver Disease, Chronic Liver Disease and Cirrhosis, Clinical Research, Good Health and Well Being, Adolescent, Biopsy, Child, Cross-Sectional Studies, Fatty Liver, Female, Hepatitis C, Histocytochemistry, Humans, Liver Cirrhosis, Male, Non-alcoholic Fatty Liver Disease, NASH, Disease Progression, Obesity, Nonalcoholic Steatohepatitis Clinical Research Network, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsFocal zone 1 steatosis, although rare in adults with nonalcoholic fatty liver disease (NAFLD), does occur in children with NAFLD. We investigated whether focal zone 1 steatosis and focal zone 3 steatosis are distinct subphenotypes of pediatric NAFLD. We aimed to determine associations between the zonality of steatosis and demographic, clinical, and histologic features in children with NAFLD.MethodsWe performed a cross-sectional study of baseline data from 813 children (age

Published
2018

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