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156. The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis

Author

Tognin, Stefania, Richter, Anja, Kempton, Matthew J., Modinos, Gemma, Antoniades, Mathilde, Azis, Matilda, Allen, Paul, Bossong, Matthijs G., Perez, Jesus, Pantelis, Christos, Nelson, Barnaby, Amminger, Paul, Riecher-Rössler, Anita, Barrantes-Vidal, Neus, Krebs, Marie Odile, Glenthøj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., De Haan, Lieuwe, Van Der Gaag, Mark, Mcguire, Philip, Valmaggia, Lucia R., Calem, Maria, Pisani, Sara, Velthorst, Eva, Kraan, Tamar C., Van Dam, Daniella S., Burger, Nadine, Mcgorry, Patrick, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Racciopi, Anna, Kwapil, Thomas R., Monsonet, Manel, Hinojosa, Lídia, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Aschauer, Harald, Delespaul, Philippe A., Van Os, Jim, Tognin, Stefania, Richter, Anja, Kempton, Matthew J., Modinos, Gemma, Antoniades, Mathilde, Azis, Matilda, Allen, Paul, Bossong, Matthijs G., Perez, Jesus, Pantelis, Christos, Nelson, Barnaby, Amminger, Paul, Riecher-Rössler, Anita, Barrantes-Vidal, Neus, Krebs, Marie Odile, Glenthøj, Birte, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., De Haan, Lieuwe, Van Der Gaag, Mark, Mcguire, Philip, Valmaggia, Lucia R., Calem, Maria, Pisani, Sara, Velthorst, Eva, Kraan, Tamar C., Van Dam, Daniella S., Burger, Nadine, Mcgorry, Patrick, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Racciopi, Anna, Kwapil, Thomas R., Monsonet, Manel, Hinojosa, Lídia, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Aschauer, Harald, Delespaul, Philippe A., and Van Os, Jim

Abstract

Objective: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis. Methods: 265 CHR individuals and 92 healthy controls were recruited as part of a prospective multi-center study. After a baseline assessment using magnetic resonance imaging (MRI), participants were followed for at least two years to determine clinical and functional outcomes, including transition to psychosis (according to the Comprehensive Assessment of an At Risk Mental State, CAARMS), level of functioning (according to the Global Assessment of Functioning), and symptomatic remission (according to the CAARMS). GMV was measured in selected cortical and subcortical regions of interest (ROI) based on previous studies (ie orbitofrontal gyrus, cingulate gyrus, gyrus rectus, inferior temporal gyrus, parahippocampal gyrus, striatum, and hippocampus). Using voxel-based morphometry, we analysed the relationship between GMV and clinical and functional outcomes. Results: Within the CHR sample, a poor functional outcome (GAF < 65) was associated with relatively lower GMV in the right striatum at baseline (P <. 047 after Family Wise Error correction). There were no significant associations between baseline GMV and either subsequent remission or transition to psychosis. Conclusions: In CHR individuals, lower striatal GMV was associated with a poor level of overall functioning at follow-up. This finding was not related to effects of antipsychotic or antidepressant medication. The failure to replicate previous associations between GMV and later psychosis onset, despite studying a relatively large sample, is consistent with the findings of recent large-scale multi-center studies.

Published
2022

157. Smartphone-based interventions in bipolar disorder:Systematic review and meta-analyses of efficacy. A position paper from the International Society for Bipolar Disorders (ISBD) Big Data Task Force

Author

Anmella, Gerard, Faurholt-Jepsen, Maria, Hidalgo-Mazzei, Diego, Radua, Joaquim, Passos, Ives C., Kapczinski, Flavio, Minuzzi, Luciano, Alda, Martin, Meier, Sandra, Hajek, Tomas, Ballester, Pedro, Birmaher, Boris, Hafeman, Danella, Goldstein, Tina, Brietzke, Elisa, Duffy, Anne, Haarman, Benno, López-Jaramillo, Carlos, Yatham, Lakshmi N., Lam, Raymond W., Isometsa, Erkki, Mansur, Rodrigo, McIntyre, Roger S., Mwangi, Benson, Vieta, Eduard, Kessing, Lars Vedel, Anmella, Gerard, Faurholt-Jepsen, Maria, Hidalgo-Mazzei, Diego, Radua, Joaquim, Passos, Ives C., Kapczinski, Flavio, Minuzzi, Luciano, Alda, Martin, Meier, Sandra, Hajek, Tomas, Ballester, Pedro, Birmaher, Boris, Hafeman, Danella, Goldstein, Tina, Brietzke, Elisa, Duffy, Anne, Haarman, Benno, López-Jaramillo, Carlos, Yatham, Lakshmi N., Lam, Raymond W., Isometsa, Erkki, Mansur, Rodrigo, McIntyre, Roger S., Mwangi, Benson, Vieta, Eduard, and Kessing, Lars Vedel

Abstract

Background: The clinical effects of smartphone-based interventions for bipolar disorder (BD) have yet to be established. Objectives: To examine the efficacy of smartphone-based interventions in BD and how the included studies reported user-engagement indicators. Methods: We conducted a systematic search on January 24, 2022, in PubMed, Scopus, Embase, APA PsycINFO, and Web of Science. We used random-effects meta-analysis to calculate the standardized difference (Hedges’ g) in pre-post change scores between smartphone intervention and control conditions. The study was pre-registered with PROSPERO (CRD42021226668). Results: The literature search identified 6034 studies. Thirteen articles fulfilled the selection criteria. We included seven RCTs and performed meta-analyses comparing the pre-post change in depressive and (hypo)manic symptom severity, functioning, quality of life, and perceived stress between smartphone interventions and control conditions. There was significant heterogeneity among studies and no meta-analysis reached statistical significance. Results were also inconclusive regarding affective relapses and psychiatric readmissions. All studies reported positive user-engagement indicators. Conclusion: We did not find evidence to support that smartphone interventions may reduce the severity of depressive or manic symptoms in BD. The high heterogeneity of studies supports the need for expert consensus to establish ideally how studies should be designed and the use of more sensitive outcomes, such as affective relapses and psychiatric hospitalizations, as well as the quantification of mood instability. The ISBD Big Data Task Force provides preliminary recommendations to reduce the heterogeneity and achieve more valid evidence in the field.

Published
2022

173. Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis

Author

Pollak, Thomas A, Kempton, Matthew J, Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R, Coutinho, Ester, Menassa, David A, Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Roessler, Anita, Krebs, Marie-Odile, Amminger, Paul, Glenthoj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart PF, Bressan, Rodrigo A, van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S, McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C, van Dam, Daniella S, Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Rosa, Araceli, Racioppi, Anna, Monsonet, Manel, Hinojosa-Marques, Lidia, Kwapil, Thomas R, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Celia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthoj, Louise, Nordentoft, Merete, Gebhard, Dominika, Arnhold, Julia, Klosterkoetter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A, Clinical Psychology, APH - Mental Health, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, Adult Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, and Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep

Subjects
Psychosis, Biochemistry & Molecular Biology, NEURONAL AUTOANTIBODIES, Verbal learning, Prognostic markers, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, ASPARTATE RECEPTOR AUTOANTIBODIES, medicine, 1ST-EPISODE PSYCHOSIS, LIMBIC ENCEPHALITIS, RATING-SCALE, BRAIN, Molecular Biology, Autoimmune disease, Autoimmune encephalitis, Psychiatry, Science & Technology, HIPPOCAMPAL, business.industry, Limbic encephalitis, Case-control study, Autoantibody, Neurosciences, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, INDIVIDUALS, nervous system, Immunology, ANTIBODIES, Schizophrenia, MENTAL STATE, Neurosciences & Neurology, business, Life Sciences & Biomedicine, 030217 neurology & neurosurgery, Neuroscience, Psychopathology
Abstract

Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. In a case–control study, sera from 254 subjects at clinical high risk (CHR) for psychosis and 116 healthy volunteers were tested for antibodies against multiple neuronal antigens implicated in CNS autoimmune disorders, using fixed and live cell-based assays (CBAs). Within the CHR group, the relationship between NMDAR antibodies and symptoms, cognitive function and clinical outcomes over 24 month follow-up was examined. CHR subjects were not more frequently seropositive for neuronal autoantibodies than controls (8.3% vs. 5.2%; OR = 1.50; 95% CI: 0.58–3.90). The NMDAR was the most common target antigen and NMDAR IgGs were more sensitively detected with live versus fixed CBAs (p p p p p

Published
2021

174. Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study

Author

Paetzold, I., Myin-Germeys, I., Schick, A., Nelson, B., Velthorst, Eva, Schirmbeck, F., Os, J., Morgan, C., Hartmann, J., van der Gaag, Mark, de Haan, Lieuwe, Valmaggia, Lucia R., McGuire, P., Kempton, Matthew J., Reininghaus, U., McGuire, Philip, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Kraan, Tamar C., Burger, Nadine, van Dam, Daniella S., Barrantes-Vidal, Neus, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R., Monsonet-Bardají, Manel, Hinojosa, Lídia, Riecher-Rössler, Anita, Borgwardt, Stefan, Rapp, Charlotte, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Bressan, Rodrigo, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Ruhrmann, Stephan, Nordholm, Dorte, Randers, Lasse, Nordentoft, Merete, Pantelis, Christos, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, Adult Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, and Amsterdam Neuroscience - Complex Trait Genetics

Subjects
Experience sampling method, Psychosis, Experience sampling method (ESM), Epidemiology, Ultra high risk, At-risk mental state, Affect (psychology), TRANSITION RATE, Stress sensitization, ECOLOGICAL MOMENTARY INTERVENTIONS, Surveys and Questionnaires, medicine, Humans, experience sampling method (ESM), EMOTIONAL REACTIVITY, Ecological momentary assessment (EMA), Depression (differential diagnoses), METAANALYSIS, Psychiatry, Science & Technology, Mechanism (biology), business.industry, Childhood abuse, BLACK-BOX, Public Health, Environmental and Occupational Health, childhood abuse, transition, EXPERIENCE SAMPLING RESEARCH, At risk mental state, medicine.disease, DEPRESSION, DAILY-LIFE STRESS, Psychiatry and Mental health, Psychotic Disorders, Transition, at-risk mental state, stress sensitization, ecological momentary assessment (EMA), SCHIZOPHRENIA SPECTRUM DISORDERS, Original Article, Self Report, SENSITIVITY, Stress reactivity, business, Life Sciences & Biomedicine, Stress, Psychological, Clinical psychology
Abstract

Aims Childhood trauma is associated with an elevated risk for psychosis, but the psychological mechanisms involved remain largely unclear. This study aimed to investigate emotional and psychotic stress reactivity in daily life as a putative mechanism linking childhood trauma and clinical outcomes in individuals at ultra-high-risk (UHR) for psychosis. Methods Experience sampling methodology was used to measure momentary stress, affect and psychotic experiences in the daily life of N = 79 UHR individuals in the EU-GEI High Risk Study. The Childhood Trauma Questionnaire was used to assess self-reported childhood trauma. Clinical outcomes were assessed at baseline, 1- and 2-year follow-up. Results The association of stress with positive (β = −0.14, p = 0.010) and negative affect (β = 0.11, p = 0.020) was modified by transition status such that stress reactivity was greater in individuals who transitioned to psychosis. Moreover, the association of stress with negative affect (β = 0.06, p = 0.019) and psychotic experiences (β = 0.05, p = 0.037) was greater in individuals exposed to high v. low levels of childhood trauma. We also found evidence that decreased positive affect in response to stress was associated with reduced functioning at 1-year follow-up (B = 6.29, p = 0.034). In addition, there was evidence that the association of childhood trauma with poor functional outcomes was mediated by stress reactivity (e.g. indirect effect: B = −2.13, p = 0.026), but no evidence that stress reactivity mediated the association between childhood trauma and transition (e.g. indirect effect: B = 0.14, p = 0.506). Conclusions Emotional and psychotic stress reactivity may be potential mechanisms linking childhood trauma with clinical outcomes in UHR individuals.

Published
2021

175. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project

Author

Calem, Maria, Tognin, Stefania, Modinos, Gemma, Pisani, Sara, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, McGorry, Patrick, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Cristóbal-Narváez, Paula, Racioppi, Anna, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Célia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise Birkedal, Glenthøj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Szöke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rössler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P.F., van Os, Jim, Velthorst, Eva, and de Haan, Lieuwe

Published
2021
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176. High risk cohort study for psychiatric disorders in childhood: rationale, design, methods and preliminary results

Author

Salum, Giovanni Abrahão, Gadelha, Ary, Pan, Pedro Mario, Moriyama, Tais Silveira, Graeff-Martins, Ana Soledade, Tamanaha, Ana Carina, Alvarenga, Pedro, Krieger, Fernanda Valle, Fleitlich-Bilyk, Bacy, Jackowski, Andrea, Sato, João Ricardo, Brietzke, Elisa, Polanczyk, Guilherme Vanoni, Brentani, Helena, de Jesus Mari, Jair, Do Rosário, Maria Conceição, Manfro, Gisele Gus, Bressan, Rodrigo Affonseca, Mercadante, Marcos Tomanik, Miguel, Eurípedes Constantino, and Rohde, Luis Augusto

Published
2015
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181. Consensus on nomenclature for clinical staging models in bipolar disorder: A narrative review from the International Society for Bipolar Disorders (ISBD) Staging Task Force

Author

Kupka, Ralph, primary, Duffy, Anne, additional, Scott, Jan, additional, Almeida, Jorge, additional, Balanzá‐Martínez, Vicent, additional, Birmaher, Boris, additional, Bond, David J., additional, Brietzke, Elisa, additional, Chendo, Ines, additional, Frey, Benicio N., additional, Grande, Iria, additional, Hafeman, Danella, additional, Hajek, Tomas, additional, Hillegers, Manon, additional, Kauer‐Sant’Anna, Marcia, additional, Mansur, Rodrigo B., additional, van der Markt, Afra, additional, Post, Robert, additional, Tohen, Mauricio, additional, Tremain, Hailey, additional, Vazquez, Gustavo, additional, Vieta, Eduard, additional, Yatham, Lakshmi N., additional, Berk, Michael, additional, Alda, Martin, additional, and Kapczinski, Flávio, additional

Published
2021
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183. Government response moderates the mental health impact of COVID-19: A systematic review and meta-analysis of depression outcomes across countries

Author

Lee, Yena, primary, Lui, Leanna M.W., additional, Chen-Li, David, additional, Liao, Yuhua, additional, Mansur, Rodrigo B., additional, Brietzke, Elisa, additional, Rosenblat, Joshua D., additional, Ho, Roger, additional, Rodrigues, Nelson B., additional, Lipsitz, Orly, additional, Nasri, Flora, additional, Cao, Bing, additional, Subramaniapillai, Mehala, additional, Gill, Hartej, additional, Lu, Ciyong, additional, and McIntyre, Roger S., additional

Published
2021
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185. Vitamin D, Depressive Symptoms, and Covid-19 Pandemic

Author

Ceolin, Gilciane, primary, Mano, Giulia Pipolo Rodrigues, additional, Hames, Natália Schmitt, additional, Antunes, Luciana da Conceição, additional, Brietzke, Elisa, additional, Rieger, Débora Kurrle, additional, and Moreira, Júlia Dubois, additional

Published
2021
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186. Peripheral Inflammatory Biomarkers Define Biotypes of Bipolar Depression

Author

Lee, Yena, primary, Mansur, Rodrigo B., additional, Brietzke, Elisa, additional, Kapogiannis, Dimitrios, additional, Delgado-Peraza, Francheska, additional, Boutilier, Justin J., additional, Chan, Timothy C.Y., additional, Carmona, Nicole E., additional, Rosenblat, Joshua, additional, Lee, JungGoo, additional, Maletic, Vladimir, additional, Vinberg, Maj, additional, Suppes, Trisha, additional, Goldstein, Benjamin I., additional, Ravindran, Arun, additional, Taylor, Valerie, additional, Cosgrove, Victoria, additional, Kramer, Nicole E., additional, Ho, Roger, additional, Raison, Charles, additional, and McIntyre, Roger S., additional

Published
2021
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187. Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation

Author

McIntyre, Roger S., primary, Rosenblat, Joshua D., additional, Nemeroff, Charles B., additional, Sanacora, Gerard, additional, Murrough, James W., additional, Berk, Michael, additional, Brietzke, Elisa, additional, Dodd, Seetal, additional, Gorwood, Philip, additional, Ho, Roger, additional, Iosifescu, Dan V., additional, Lopez Jaramillo, Carlos, additional, Kasper, Siegfried, additional, Kratiuk, Kevin, additional, Lee, Jung Goo, additional, Lee, Yena, additional, Lui, Leanna M.W., additional, Mansur, Rodrigo B., additional, Papakostas, George I., additional, Subramaniapillai, Mehala, additional, Thase, Michael, additional, Vieta, Eduard, additional, Young, Allan H., additional, Zarate, Carlos A., additional, and Stahl, Stephen, additional

Published
2021
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188. Clinical, cognitive and neuroanatomical associations of serum NMDAR autoantibodies in people at clinical high risk for psychosis

Author

Pollak, Thomas A., Kempton, Matthew J., Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R., Coutinho, Ester, Menassa, David A., Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Rössler, Anita, Krebs, Marie Odile, Amminger, Paul, Glenthøj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart P.F., Bressan, Rodrigo A., van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Nordholm, Dorte, Randers, Lasse, Nordentoft, Merete, Pollak, Thomas A., Kempton, Matthew J., Iyegbe, Conrad, Vincent, Angela, Irani, Sarosh R., Coutinho, Ester, Menassa, David A., Jacobson, Leslie, de Haan, Lieuwe, Ruhrmann, Stephan, Sachs, Gabriele, Riecher-Rössler, Anita, Krebs, Marie Odile, Amminger, Paul, Glenthøj, Birte, Barrantes-Vidal, Neus, van Os, Jim, Rutten, Bart P.F., Bressan, Rodrigo A., van der Gaag, Mark, Yolken, Robert, Hotopf, Matthew, Valmaggia, Lucia, Stone, James, David, Anthony S., Calem, Maria, Tognin, Stefania, Modinos, Gemma, Velthorst, Eva, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, Nelson, Barnaby, McGorry, Patrick, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Ittig, Sarah, Studerus, Erich, Smieskova, Renata, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Nordholm, Dorte, Randers, Lasse, and Nordentoft, Merete

Abstract

Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with particular clinical features or outcomes. In a case–control study, sera from 254 subjects at clinical high risk (CHR) for psychosis and 116 healthy volunteers were tested for antibodies against multiple neuronal antigens implicated in CNS autoimmune disorders, using fixed and live cell-based assays (CBAs). Within the CHR group, the relationship between NMDAR antibodies and symptoms, cognitive function and clinical outcomes over 24 month follow-up was examined. CHR subjects were not more frequently seropositive for neuronal autoantibodies than controls (8.3% vs. 5.2%; OR = 1.50; 95% CI: 0.58–3.90). The NMDAR was the most common target antigen and NMDAR IgGs were more sensitively detected with live versus fixed CBAs (p < 0.001). Preliminary phenotypic analyses revealed that within the CHR sample, the NMDAR antibody seropositive subjects had higher levels of current depression, performed worse on the Rey Auditory Verbal Learning Task (p < 0.05), and had a markedly lower IQ (p < 0.01). NMDAR IgGs were not more frequent in subjects who later became psychotic than those who did not. NMDAR antibody serostatus and titre was associated with poorer levels of functioning at follow-up (p < 0.05) and the presence of a neuronal autoantibody was associated with larger amygdala volumes (p < 0.05). Altogether, these findings demonstrate that NMDAR autoantibodies are detectable in a subgroup of CHR subjects at equal rates to controls. In the CHR group, they are associated with affective psychopathology, impairments in verbal memory, and overall cognitive function: these findings are qualitatively and individually similar to core features of autoimmune encephalitis and/or animal models of NMDAR antibody-mediated CNS disease. Ov

Published
2021

189. Consensus on nomenclature for clinical staging models in bipolar disorder:A narrative review from the International Society for Bipolar Disorders (ISBD) Staging Task Force

Author

Kupka, Ralph, Duffy, Anne, Scott, Jan, Almeida, Jorge, Balanzá-Martínez, Vicent, Birmaher, Boris, Bond, David J., Brietzke, Elisa, Chendo, Ines, Frey, Benicio N., Grande, Iria, Hafeman, Danella, Hajek, Tomas, Hillegers, Manon, Kauer-Sant’Anna, Marcia, Mansur, Rodrigo B., van der Markt, Afra, Post, Robert, Tohen, Mauricio, Tremain, Hailey, Vazquez, Gustavo, Vieta, Eduard, Yatham, Lakshmi N., Berk, Michael, Alda, Martin, Kapczinski, Flávio, Kupka, Ralph, Duffy, Anne, Scott, Jan, Almeida, Jorge, Balanzá-Martínez, Vicent, Birmaher, Boris, Bond, David J., Brietzke, Elisa, Chendo, Ines, Frey, Benicio N., Grande, Iria, Hafeman, Danella, Hajek, Tomas, Hillegers, Manon, Kauer-Sant’Anna, Marcia, Mansur, Rodrigo B., van der Markt, Afra, Post, Robert, Tohen, Mauricio, Tremain, Hailey, Vazquez, Gustavo, Vieta, Eduard, Yatham, Lakshmi N., Berk, Michael, Alda, Martin, and Kapczinski, Flávio

Abstract

Objectives: Clinical staging is widely used in medicine to map disease progression, inform prognosis, and guide treatment decisions; in psychiatry, however, staging remains a hypothetical construct. To facilitate future research in bipolar disorders (BD), a well-defined nomenclature is needed, especially since diagnosis is often imprecise with blurred boundaries, and a full understanding of pathophysiology is lacking. Methods: Under the auspices of the International Society of Bipolar Disorders, a Task Force of international experts was convened to review, discuss, and integrate findings from the scientific literature relevant to the development of a consensus staging model and standardize a terminology that could be used to advance future research including staging of BD and related disorders. Results: Consensus opinion and areas of uncertainty or difference were identified in regard to terms referring to staging as it may apply to BD, to at-risk status and subthreshold stages, and to various clinical stages of BD as it is currently diagnosed. Conclusion: The use of a standardized nomenclature about the clinical stages of BD will facilitate communication about research on clinical and pathological components of this heterogeneous group of disorders. The concepts presented are based on current evidence, but the template provided allows for further refinements as etiological advances come to light.

Published
2021

191. Corrigendum to “Applications of machine learning algorithms to predict therapeutic outcomes in depression: A meta-analysis and systematic review.” J Affect Disord. 241 (2018) 519-532

Author

Lee, Yena, Ragguett, Renee-Marie, Mansur, Rodrigo B., Boutilier, Justin J., Rosenblat, Joshua D., Trevizol, Alisson, Brietzke, Elisa, Lin, Kangguang, Pan, Zihang, Subramaniapillai, Mehala, Chan, Timothy C.Y., Fus, Dominika, Park, Caroline, Musial, Natalie, Zuckerman, Hannah, Chen, Vincent Chin-Hung, Ho, Roger, Rong, Carola, and McIntyre, Roger S.

Published
2020
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196. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project

Author

Berendsen, Steven, primary, Kapitein, Pim, additional, Schirmbeck, Frederike, additional, van Tricht, Mirjam J., additional, McGuire, Philip, additional, Morgan, Craig, additional, Gayer-Anderson, Charlotte, additional, Kempton, Matthew J., additional, Valmaggia, Lucia, additional, Quattrone, Diego, additional, di Forti, Marta, additional, van der Gaag, Mark, additional, Kirkbride, James B., additional, Jongsma, Hannah E., additional, Jones, Peter B., additional, Parellada, Maria, additional, Arango, Celso, additional, Arrojo, Manuel, additional, Bernardo, Miguel, additional, Sanjuán, Julio, additional, Santos, José Luis, additional, Szöke, Andrei, additional, Tortelli, Andrea, additional, Llorca, Pierre-Michel, additional, Tarricone, Ilaria, additional, Tripoli, Giada, additional, Ferraro, Laura, additional, La Cascia, Caterina, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Menezes, Paulo Rossi, additional, Del-Ben, Cristina Marta, additional, Nelson, Barnaby, additional, Riecher-Rössler, Anita, additional, Bressan, Rodrigo, additional, Barrantes-Vidal, Neus, additional, Krebs, Marie-Odile, additional, Nordentoft, Merete, additional, Ruhrmann, Stephan, additional, Sachs, Gabriele, additional, Rutten, Bart P.F., additional, van Os, Jim, additional, Velthorst, Eva, additional, de Haan, Lieuwe, additional, Calem, Maria, additional, Tognin, Stefania, additional, Modinos, Gemma, additional, Pisani, Sara, additional, Kraan, Tamar C., additional, van Dam, Daniella S., additional, Burger, Nadine, additional, McGorry, Patrick, additional, Amminger, G. Paul, additional, Politis, Athena, additional, Goodall, Joanne, additional, Borgwardt, Stefan, additional, Studerus, Erich, additional, Gadelha, Ary, additional, Brietzke, Elisa, additional, Asevedo, Graccielle, additional, Asevedo, Elson, additional, Zugman, Andre, additional, Domínguez-Martínez, Tecelli, additional, Monsonet, Manel, additional, Hinojosa, Lidia, additional, Cristóbal-Narváez, Paula, additional, Racioppi, Anna, additional, Kwapil, Thomas R., additional, Kazes, Mathilde, additional, Daban, Claire, additional, Bourgin, Julie, additional, Gay, Olivier, additional, Mam-Lam-Fook, Célia, additional, Nordholm, Dorte, additional, Randers, Lasse, additional, Krakauer, Kristine, additional, Glenthøj, Louise Birkedal, additional, Glenthøj, Birte, additional, Gebhard, Dominika, additional, Arnhold, Julia, additional, Klosterkötter, Joachim, additional, Lasser, Iris, additional, Winklbaur, Bernadette, additional, and Delespaul, Philippe A., additional

Published
2021
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198. Dysregulated Lipid Metabolism Precedes Onset of Psychosis

Author

Dickens, Alex M., primary, Sen, Partho, additional, Kempton, Matthew J., additional, Barrantes-Vidal, Neus, additional, Iyegbe, Conrad, additional, Nordentoft, Merete, additional, Pollak, Thomas, additional, Riecher-Rössler, Anita, additional, Ruhrmann, Stephan, additional, Sachs, Gabriele, additional, Bressan, Rodrigo, additional, Krebs, Marie-Odile, additional, Amminger, G. Paul, additional, de Haan, Lieuwe, additional, van der Gaag, Mark, additional, Valmaggia, Lucia, additional, Hyötyläinen, Tuulia, additional, Orešič, Matej, additional, McGuire, Philip, additional, Valmaggia, Lucia R., additional, Calem, Maria, additional, Tognin, Stefania, additional, Modinos, Gemma, additional, Velthorst, Eva, additional, Kraan, Tamar C., additional, van Dam, Daniella S., additional, Burger, Nadine, additional, Nelson, Barnaby, additional, McGorry, Patrick, additional, Pantelis, Christos, additional, Politis, Athena, additional, Goodall, Joanne, additional, Borgwardt, Stefan, additional, Rapp, Charlotte, additional, Ittig, Sarah, additional, Studerus, Erich, additional, Smieskova, Renata, additional, Gadelha, Ary, additional, Brietzke, Elisa, additional, Asevedo, Graccielle, additional, Asevedo, Elson, additional, Zugman, Andre, additional, Domínguez-Martínez, Tecelli, additional, Racciopi, Anna, additional, Kwapil, Thomas R., additional, Monsonet, Manel, additional, Rosa, Araceli, additional, Frajerman, Ariel, additional, Chaumette, Boris, additional, Bourgin, Julie, additional, Kebir, Oussama, additional, Jantac, Célia, additional, Nordholm, Dorte, additional, Randers, Lasse, additional, Krakauer, Kristine, additional, Glenthøj, Louise, additional, Glenthøj, Birte, additional, Gebhard, Dominika, additional, Arnhold, Julia, additional, Klosterkötter, Joachim, additional, Lasser, Iris, additional, Winklbaur, Bernadette, additional, Delespaul, Philippe A., additional, Rutten, Bart P., additional, and van Os, Jim, additional

Published
2021
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199. Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder

Author

Gomes, Fabiano Alves, Magalhães, Pedro Vieira da Silva, Magee, Taylor, Brietzke, Elisa Macedo, Kunz, Maurício, and Kapczinski, Flávio Pereira

Subjects
Cirs, Bipolar disorder, Comorbidade, Transtorno bipolar, General medical comorbidity
Abstract

Background: Bipolar disorder is associated with an increased burden of general medical conditions that might be related to a more severe illness course. Methods: This is a cross-sectional study that evaluated clinical correlates of general medical comorbidities in outpatients with bipolar disorder (BD) involving 203 adult patients with a DSM-IV diagnosis of BD, consecutively recruited from the Bipolar Research Program (PROTAHBI) in Porto Alegre, Brazil. Clinical, demographic and anthropometrical variables were systematically assessed, and general medical comorbidity was measured using the Cumulative Illness Rating Scale (CIRS). Results: The prevalence of one or more medical comorbidities was 90.1%. The most common were those from endocrine/metabolic/breast, neurologic and vascular categories. A high burden of general medical comorbidities (defined as CIRS total score ≥ 4) was related to increasing age and body mass index and longer duration of illness after controlling for confounding factors. Limitations: The cross-sectional design limits our ability to make causal conclusions. Also, our sample consisted of patients with longer illness duration from a tertiary clinic and may not generalize to the whole spectrum of bipolar disorder. Conclusions: BD was associated with a high burden of general medical conditions related to age, obesity and longer duration of illness. Medical comorbidities must be incorporated as a core feature in the development of effective treatment strategies for bipolar disorder.

Published
2020

200. From Speech Illusions to Onset of Psychotic Disorder: Applying Network Analysis to an Experimental Measure of Aberrant Experiences

Author

Boyette, Lindy-Lou, Isvoranu, Adela-Maria, Schirmbeck, Frederike, Velthorst, Eva, Simons, Claudia J P, Barrantes-Vidal, Neus, Bressan, Rodrigo, Kempton, Matthew J, Krebs, Marie-Odile, McGuire, Philip, Nelson, Barnaby, Nordentoft, Merete, Riecher-Rössler, Anita, Ruhrmann, Stephan, Rutten, Bart P, Sachs, Gabriele, Valmaggia, Lucia R, van der Gaag, Mark, Borsboom, Denny, de Haan, Lieuwe, van Os, Jim, Calem, Maria, Tognin, Stefania, Modinos, Gemma, Kraan, Tamar C, van Dam, Daniella S, Burger, Nadine, McGorry, Patrick, Amminger, G Paul, Pantelis, Christos, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Cristóbal-Narváez, Paula, Kwapil, Thomas R, Monsonet, Manel, Hinojosa, Lídia, Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Célia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise, Glenthøj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A, Klinische Psychologie (Psychologie, FMG), and Psychologische Methodenleer (Psychologie, FMG)

Subjects
Psychosis, media_common.quotation_subject, Illusion, Network structure, Ideation, Affect (psychology), medicine.disease, 030227 psychiatry, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, medicine, In patient, Psychology, 030217 neurology & neurosurgery, Depression (differential diagnoses), Network approach, Clinical psychology, media_common
Abstract

Aberrant perceptional experiences are a potential early marker of psychosis development. Earlier studies have found experimentally assessed speech illusions to be associated with positive symptoms in patients with psychotic disorders, but findings for attenuated symptoms in individuals without psychotic disorders have been inconsistent. Also, the role of affect is unclear. The aim of this study was to use the network approach to investigate how speech illusions relate to individual symptoms and onset of a psychotic disorder. We estimated a network model based on data from 289 Clinical High-Risk (CHR) subjects, participating in the EU-GEI project. The network structure depicts statistical associations between (affective and all) speech illusions, cross-sectional individual attenuated positive and affective symptoms, and transition to psychotic disorder after conditioning on all other variables in the network. Speech illusions were assessed with the White Noise Task, symptoms with the BPRS and transition during 24-month follow-up with the CAARMS. Affective, not all, speech illusions were found to be directly, albeit weakly, associated with hallucinatory experiences. Hallucinatory experiences, in turn, were associated with delusional ideation. Bizarre behavior was the only symptom in the network steadily predictive of transition. Affective symptoms were highly interrelated, with depression showing the highest overall strength of connections to and predictability by other symptoms. Both speech illusions and transition showed low overall predictability by symptoms. Our findings suggest that experimentally assessed speech illusions are not a mere consequence of psychotic symptoms or disorder, but that their single assessment is likely not useful for assessing transition risk.

Published
2020

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