497 results on '"Bowden N"'
Search Results
152. Gabrielseet al.Reply
- Author
-
Gabrielse, G., primary, Bowden, N. S., additional, Oxley, P., additional, Speck, A., additional, Storry, C. H., additional, Tan, J. N., additional, Wessels, M., additional, Grzonka, D., additional, Oelert, W., additional, Schepers, G., additional, Sefzick, T., additional, Walz, J., additional, Pittner, H., additional, Hänsch, T. W., additional, and Hessels, E. A., additional
- Published
- 2004
- Full Text
- View/download PDF
153. Progress Towards Deployable Antineutrino Detectors for Reactor Safeguards.
- Author
-
Bowden, N. S., Bernstein, A., Dazeley, S., Keefer, G., Reyna, D., Cabrera-Palmer, B., and Kiff, S.
- Subjects
ANTINEUTRINOS ,DETECTORS ,NUCLEAR reactor safety measures ,PLUTONIUM ,BULK solids - Abstract
Fission reactors emit large numbers of antineutrinos and this flux may be useful for the measurement of two quantities of interest for reactor safeguards: the reactor's power and plutonium inventory throughout its cycle. The high antineutrino flux and relatively low background rates means that simple cubic meter scale detectors at tens of meters standoff can record hundreds or thousands of antineutrino events per day. Such antineutrino detectors would add online, quasi-real-time bulk material accountancy to the set of reactor monitoring tools available to the IAEA and other safeguards agencies with minimal impact on reactor operations. Between 2003 and 2008, our LLNL/SNL collaboration successfully deployed several prototype safeguards detectors at a commercial reactor in order to test both the method and the practicality of its implementation in the field. Partially on the strength of the results obtained from these deployments, an Experts Meeting was convened by the IAEA Novel Technologies Group in 2008 to assess current antineutrino detection technology and examine how it might be incorporated into the safeguards regime. Here we present a summary of our previous deployments and discuss current work that seeks to provide expanded capabilities suggested by the Experts Panel, in particular aboveground detector operation. [ABSTRACT FROM AUTHOR]
- Published
- 2010
154. Integrated readout of organic scintillator and ZnS:Ag/6LiF for segmented antineutrino detectors.
- Author
-
Kiff, S.D., Bowden, N., Monahan, J., and Reyna, D.
- Published
- 2010
- Full Text
- View/download PDF
155. SNM Detection with a Large Water Cerenkov Detector.
- Author
-
Dazeley, S., Bernstein, A., Bowden, N. S., Ouedraogo, S., Svoboda, R., and Sweany, M.
- Subjects
NUCLEAR matter ,NEUTRONS ,CHERENKOV radiation ,DETECTORS ,GADOLINIUM isotopes - Abstract
Special Nuclear Material (SNM) can either spontaneously fission, or be induced to do so. Either case results in neutron emission. Since neutrons are highly penetrating and difficult to shield, they could, potentially, be detected escaping even a well shielded cargo container. Obviously, if the shielding is sophisticated, detecting it would require a highly efficient detector with close to 4π solid angle coverage. Water Cerenkov detectors may be a cost effective way to achieve that goal if it can be shown that the neutron capture signature is large enough and if sufficient background rejection can be employed as detectors get larger. In 2008 the LLNL Advanced Detector Group reported the successful detection of neutrons with a ¼ ton gadolinium doped water Cerenkov prototype. We have now built a 4 ton version. This detector is not only bigger, it was designed with photon detection efficiency in mind from the beginning. We are employing increased photocathode coverage and more reflective walls, coated with PTFE. The increased efficiency should allow better energy resolution. We expect that the better diffusive wall reflectivity will reduce the overall dependence of the detector response on particle direction, again producing a more consistent response. We also believe that as detectors get larger, both uncorrelated and correlated backgrounds due to gamma-rays and cosmic ray interactions near the detector will increase. To prove the effectiveness of the technology we must develop new ways to reject these backgrounds while maintaining our sensitivity to SNM neutrons. Better energy resolution will enable us to reject more of the low energy gamma-ray backgrounds on this basis. Overcoming cosmic ray induced neutrons is perhaps an even larger concern as detectors get larger. Our detector is designed so that we can test various segmentation schemes - effectively dividing the detector up into smaller ones. In this presentation, we will describe our detector in detail. [ABSTRACT FROM AUTHOR]
- Published
- 2009
156. Directional Detection of Fast Neutrons Using a Time Projection Chamber.
- Author
-
Bowden, N. S., Heffner, M., Carosi, G., Carter, D., Foxe, M., and Jovanovic, I.
- Subjects
TIME projection chambers (Nuclear physics) ,FAST neutrons -- Capture ,NUCLEAR fuels ,NUCLEAR reactor materials ,PROTONS ,DATA analysis - Abstract
The article discusses the use of a time projection chamber (TPC) to detect fast neutrons emitted by spontaneous fission in special nuclear material (SNM). It outlines the application and operation of TPC for SNM imaging that promises high directional detection efficiency. It notes the use of reconstruction software for data analysis and observation on proton recoils and to track algorithm based on a combination of a standard Hough transform algorithm.
- Published
- 2009
157. Driven Production of Cold Antihydrogen and the First Measured Distribution of Antihydrogen States
- Author
-
Gabrielse, G., primary, Bowden, N. S., additional, Oxley, P., additional, Speck, A., additional, Storry, C. H., additional, Tan, J. N., additional, Wessels, M., additional, Grzonka, D., additional, Oelert, W., additional, Schepers, G., additional, Sefzick, T., additional, Walz, J., additional, Pittner, H., additional, Hänsch, T. W., additional, and Hessels, E. A., additional
- Published
- 2002
- Full Text
- View/download PDF
158. Background-Free Observation of Cold Antihydrogen with Field-Ionization Analysis of Its States
- Author
-
Gabrielse, G., primary, Bowden, N. S., additional, Oxley, P., additional, Speck, A., additional, Storry, C. H., additional, Tan, J. N., additional, Wessels, M., additional, Grzonka, D., additional, Oelert, W., additional, Schepers, G., additional, Sefzick, T., additional, Walz, J., additional, Pittner, H., additional, Hänsch, T. W., additional, and Hessels, E. A., additional
- Published
- 2002
- Full Text
- View/download PDF
159. COLD ANTIHYDROGEN AND CPT
- Author
-
GABRIELSE, G., primary, TAN, J. N., additional, BOWDEN, N. S., additional, OXLEY, P., additional, STORRY, C. H., additional, WESSELS, M., additional, SPECK, A., additional, ESTRADA, J., additional, YESLEY, P., additional, GRZONKA, D., additional, OELERT, W., additional, SCHEPERS, G., additional, SEFZICK, T., additional, and WALZ, J., additional
- Published
- 2002
- Full Text
- View/download PDF
160. A prototype experiment for cooperative monitoring of nuclear reactors with cubic meter scale antineutrino detectors.
- Author
-
Bernstein, A., Allen, M., Bowden, N., Brennan, J., Carr, D. J., Estrada, J., Hagmann, C., Lund, J. C., Madden, N. W., and Winant, C. D.
- Published
- 2005
- Full Text
- View/download PDF
161. Cold antimatter plasmas, and aspirations for cold antihydrogen.
- Author
-
Gabrielse, G., Tan, J. N., Bowden, N. S., Oxley, P., Storry, C. H., Wessels, M., Speck, A., Estrada, J., Yesley, P., Squires, T., Grzonka, D., Oelert, W., Schepers, G., Sefzick, T., and Walz, J.
- Subjects
ANTIPROTONS ,POSITRONS ,PLASMA gases - Abstract
Only our ATRAP Collaboration is yet able to accumulate and store 4.2 K antiprotons and positrons. The antiprotons come initially from the new Antiproton Decelerator facility at CERN. Good control of such cold antimatter plasmas is key to aspirations to produce and study antihydrogen atoms that are cold enough to confine by their magnetic moments. In the closest approach to cold antihydrogen realized to date, the cold positrons have been used to cool antiprotons, the first time that positron cooling has ever been observed. The Penning-Ioffe trap, one possibility for simultaneously confining antihydrogen and the cold ingredients from which it is formed, is introduced and discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2002
162. Energy of the superallowed β decay of38Km
- Author
-
Harty, P. D., primary, Bowden, N. S., additional, Barker, P. H., additional, and Amundsen, P. A., additional
- Published
- 1998
- Full Text
- View/download PDF
163. ChemInform Abstract: Catalytic Ring Closing Metathesis of Dienynes: Construction of Fused Bicyclic Rings.
- Author
-
KIM, S.‐H., primary, BOWDEN, N., additional, and GRUBBS, R. H., additional
- Published
- 1995
- Full Text
- View/download PDF
164. Genetic changes correlate with histopathology in a benign, borderline and malignant mucinous ovarian tumour.
- Author
-
Bowden, N. A., Smyth, M., Jaaback, K., Ashton, K. A., and Scurry, J.
- Subjects
- *
OVARIAN cysts , *GENETIC testing , *CHROMOSOME abnormalities , *HISTOPATHOLOGY , *BENIGN tumors , *CANCER cells , *OVARIAN tumors , *TUMORS , *OLIGONUCLEOTIDE arrays , *GENOTYPES - Abstract
The article presents a case study of a 48-year-old woman suffering from bilateral salpingo-oophorectomy, omentectomy in large right ovarian mass. Topics discussed include no detection of surface tumor, surgicopathological diagnosis of FIGO stage with benign and borderline areas, her genetic studies showing copy-number (CN) aberrations, and CN analysis of genome suggesting correlation of genetic changes with histopathology in benign and malignant ovarian tumour.
- Published
- 2016
- Full Text
- View/download PDF
165. A 1q44 deletion, paternal UPD of chromosome 2 and a deletion due to a complex translocation detected in children with abnormal phenotypes using new SNP array technology.
- Author
-
Talseth-Palmer, B. A., Bowden, N. A., Meldrum, C., Nicholl, J., Thompson, E., Friend, K., Liebelt, J., Bratkovic, D., Haan, E., Yu, S., and Scott, R. J.
- Subjects
- *
CHROMOSOMES , *JUVENILE diseases , *INTELLECTUAL development , *KARYOTYPES , *CYTOGENETICS , *CYTOLOGY , *GENOMES , *PATIENTS - Abstract
Children with intellectual disability, dysmorphic features, malformations and/or growth abnormalities frequently display normal karyotypes. Recent studies have shown that genome-wide single nucleotide polymorphism (SNP) arrays can be effective in detecting abnormalities involving copy number variation (CNV), deletions, duplications and loss of heterozygosity (LOH) that routine cytogenetic tests fail to identify. Five patients with various degrees of intellectual disability and/or dysmorphic features and other malformations were whole-genome genotyped using the Human-1 Genotyping BeadChip – Exon-Centrix 100K SNP arrays (Illumina). All patients had undergone routine cytogenetic testing; four patients had normal karyotypes, while one patient had an apparently balanced complex translocation involving chromosomes 1q25, 1q32, 2q23, 7q22 and 16q24. We detected deletions on chromosome 1q44 and 13q31.1 in one patient, and LOH of the entire chromosome 2 in another patient, both with cytogenetically normal karyotypes. The patient with the complex translocation had a deletion on chromosome 7q22.2-22.3, which is in conjunction with one of the translocation breakpoints. Our findings provide further evidence of there being a critical region for the development of microcephaly and corpus callosum abnormalities in children with distal 1q deletions. We have also shown that apparently balanced complex translocations might not be balanced at the DNA level, and we report the fourth case of paternal uniparental disomy of chromosome 2. The results of this study suggest that it may be desirable to investigate idiopathic mental retardation using genome-wide SNP arrays, in conjunction with other cytogenetic and molecular techniques. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
166. An in vivo study of the total occlusion method for the analysis of forward and backward pressure waves.
- Author
-
NEWMAN, D. L., GREENWALD, S. E., and BOWDEN, N. L. R.
- Abstract
The arterial pressure wave, Pm, is composed of a forward travelling wave, Pt, and a backward travelling wave, Pb, resulting from partial reflection of Pt at the peripheral beds. The magnitude of Pb depends on the degree of vasoconstriction. Total occlusion of the vessel distal to the pressure measurement site results in a wave which is equal to 2Pf. Subtraction of the derived Pf wave from Pm gives Pb, provided there is no re-reflection of Pb by proximal discontinuities. To test the validity of this total occlusion method for the determination of the components of Pm, measurements were carried out in an anaesthetised dog and the results compared with the method of Westerhof et al., (1972). The measurements were made at three arterial sites: 1. in the aorta just proximal to the junction of the renal artery; 2. at the termination of the aorta; and 3. in the femoral artery. The magnitude of Pb was varied by the infusion of vascoactive drugs. There was good agreement between the two methods at site 1 but at the other two sites the agreement was less good. It is shown that this is the result of re-reflection of the backward travelling waves produced by the occlusion at the aortic termination and the renal artery junction. [ABSTRACT FROM PUBLISHER]
- Published
- 1979
167. Comparison between theoretical and directly measured pulse propagation velocities in the aorta of the anaesthetised dog.
- Author
-
GREENWALD, S. E., NEWMAN, D. L., and BOWDEN, N. L. R.
- Abstract
The propagation velocity (Cm) of the flow and pressure pulse has been measured in the abdominal aorta of anaesthetised dogs under vasoconstricted and vasodilated conditions. Simultaneously, measurements of the pressure strain elastic modulus (Ep) were obtained using a mercury in silastic strain gauge. These values of Ep were used to estimate a calculated propagation velocity (Cc) derived from the Moens Korteweg relationship.After Fourier analysing the pressure, flow and radius data it was found that Cc showed very little frequency dependence and that during vasodilatation Cm ≈ Cc to within a few percent for all harmonics above the first; whilst during vasoconstriction close agreement was observed at harmonics ≥ 6th. The mean values of Cm for these higher harmonics, and Cc for all harmonics, together with the mean propagation velocity (Cff) obtained from foot-to-foot time delays were, during vasodilation :Cm = 5.88 ± 1.2 (SD), Cc = 6.00 ± 1.04 and Cff = 5.79 ± 1.03 and during vasoconstriction Cm = 8.04 ± 1.27, Cc = 8.10 ± 1.04 and Cff = 8.00 ± 1.16. (units ms−1)Measurements in one dog of the impedance (ratio of pressure to flow) demonstrated that the contribution of peripheral reflections was negligible for the 6th and subsequent harmonics during vasoconstriction and above the first harmonic during vasodilatation, suggesting that the lack of agreement at lower frequencies between measured and calculated velocities was due to the presence of reflected waves.We conclude that within the frequency range in which reflected waves are negligible the Moens Korteweg equation in conjunction with measurements of pulse propagation velocity may be used to obtain accurate information on the elastic properties of the aorta. [ABSTRACT FROM PUBLISHER]
- Published
- 1978
168. Partial standing wave formation above an abdominal aortic stenosis1.
- Author
-
NEWMAN, D. L., BATTEN, J. R., and BOWDEN, N. L. R.
- Abstract
Reflection from an arterial discontinuity, such as a stenosis, would be expected to produce partial standing waves of pressure and flow proximal to the stenosis. This phenomenon is demonstrated by determining the amplitude changes of the harmonic components of pressure and flow waves recorded at three sites at different distances from an experimental stenosis of the abdominal aorta in dogs. To minimise the effect of reflections from other arterial sites, such as the peripheral beds, the animals were vasodilated. Impedance and propagation velocity measurements were made to estimate the contribution of peripheral reflections in the harmonic components of the aortic pressure and flow pulses. In general, the peripheral contribution appeared to be small for harmonics greater than the first. The results indicate that, for the ‘closed’ type of reflection at the stenosis, a pressure antinode and a flow node occur immediately proximal to the stenosis. As the distance from the stenosis to the measurement site is increased, nodes and antinodes of pressure and flow occur at frequencies which correspond to integer multiples of λ/4. Similar fluctuations take place in the impedance modulus proximal to the stenosis, such that close to the stenosis the modulus is a maximum, at the λ/4 distance the modulus is a minimum and at the λ/2 distance it is again a maximum. The extent of these impedance changes with distance indicates that the attenuation of the reflected, backwardgoing waves is greater than found for forwardgoing waves and that the diagnostic assessment of a vascular obstruction by means of a proximal measurement of pressure or flow may be subject to error if the measurement is not made close to the obstruction. [ABSTRACT FROM PUBLISHER]
- Published
- 1977
169. The dynamic and static elastic response of the abdominal aorta of the dog.
- Author
-
NEWMAN, D. L., BOWDEN, N. L. R., and GOSLING, R. G.
- Abstract
The dynamic and static elastic response of the abdominal aorta was studied in beagle dogs of similar age and weight. The dynamic response was measured in situ by means of an optical transmission wedge resting on the exposed vessel to record the pulsatile changes in wall displacement and the pressure pulse recorded at the same site via a hypodermic needle. The static response was recorded (1) in situ by observing the change in radius which occurred with a change in the mean blood pressure, (2) post mortem using both transmission wedge and radiographic techniques. The change in radius (ΔR) for a change in pressure (ΔP=20 mm Hg [2.67 kPa]) was calculated for both the dynamic and static cases. It was found that the aorta was stiffer for the dynamic case, the extent of the stiffening being dependent on the mean pressure. At pressures less than 80 mm Hg (10.64 kPa) the dynamic/static ΔR ratio was 1.8, decreasing to 1.1 at 160 mm Hg (21.28 kPa). This behaviour is interpreted in terms of smooth muscle relaxation and the subsequent transference of circumferential tension to collagen. [ABSTRACT FROM PUBLISHER]
- Published
- 1975
170. Bicuspid mitral bioprosthesis.
- Author
-
Bodnar, E, Bowden, N L, Drury, P J, Olsen, E G, Durmaz, I, and Ross, D N
- Subjects
MITRAL valve surgery ,ANIMAL experimentation ,COMPARATIVE studies ,DOGS ,PROSTHETIC heart valves ,RESEARCH methodology ,MEDICAL cooperation ,MITRAL valve ,MYOCARDIUM ,RESEARCH ,EVALUATION research - Abstract
A bicuspid mitral bioprosthesis was prepared by mounting glutaraldehyde-processed porcine pericardium onto commercially available Brownlee-Yates stents. The bioprostheses were inserted into 17 dogs. Haemodynamic performance and long-term function of the valve was assessed. Of the 11 animals in the survival group, eight died within the 24-72 hour postoperative period. The clinical picture of these animals revealed progressive left ventricular failure although the bioprostheses were tested and found competent both at insertion and at necropsy. The causes of the late deaths were deterioration of the porcine pericardium in two, and cerebral embolism in another. The acute haemodynamic studies showed a significantly high closing reflux from within the tubular bioprosthesis, and this reflux was found to be inherent in the design. It was concluded that any stented bicuspid valve where the stent assumes the function of the papillary muscles, has to be tailored so that parts of the tissue can assume the function of the chordae tendineae to minimise the closing reflux. [ABSTRACT FROM AUTHOR]
- Published
- 1981
171. Simple Methods for the Direct Assembly, Functionalization, and Patterning of Acid-Terminated Monolayers on Si(111)
- Author
-
Perring, M., Dutta, S., Arafat, S., Mitchell, M., Kenis, P. J. A., and Bowden, N. B.
- Abstract
This article describes mild methods to directly assemble, functionalize, and pattern monolayers of undecylenic acid on hydrogen-terminated Si(111). These monolayers were assembled under very mild conditions from a neat solution of undecylenic acid containing 0.1 mol % 4-(decanoate)-2,2,6,6-tetramethylpiperidinooxy at room temperature without the need for UV light. Because of these mild conditions, monolayers exposing carboxylic acids could be assembled in one step without the need to protect the acid prior to its assembly. The monolayers were extensively characterized by horizontal attenuated total reflection infrared spectroscopy, X-ray photoelectron spectroscopy (XPS), and contact angle goniometry. The monolayers bonded to the silicon surface preferentially through the olefin with no detectable bonds between the carboxylic acids and silicon. The crystallinity of the monolayer was studied by infrared spectroscopy through the antisymmetric&sbd;v
a (CH2 )&sbd;and symmetric&sbd;vs (CH2 )&sbd;stretches for methylene. Because it is important for future applications to assemble functional surfaces, methods to react the acid-terminated monolayers with trifluoroacetic anhydride and triethylamine to yield a symmetric anhydride on the monolayer were studied. These anhydrides were reacted with a variety of milligram-quantity amines to yield amide-terminated surfaces. This method was general, and a variety of amines could be bonded to the monolayer. The stabilities of these monolayers upon exposure to ambient conditions and under a variety of solvents were described. Because patterned monolayers have found wide applications, we have developed methods to pattern 1-octadecylamine and poly(ethylenimine) on the micrometer scale using soft lithography. In addition, polymer brushes of polynorbornene with thicknesses from 32 to 150 nm were grown from monolayers patterned with the Grubbs' catalyst. The patterned surfaces were imaged by scanning electron microscopy, scanning probe microscopy, and ellipsometry to determine the thicknesses of the patterns and the fidelity of the method.- Published
- 2005
172. Synthesis of Ultralarge Molecular Weight Bottlebrush Polymers Using Grubbs' Catalysts
- Author
-
Jha, S., Dutta, S., and Bowden, N. B.
- Abstract
This paper describes two methods to synthesize bottlebrush polymers with molecular weights from 1 million to over 60 million g mol-1 using Grubbs' first and second generation catalysts. In the first method, macromonomers of poly(
l -lactide) were synthesized using tin(II) 2-ethylhexanoate and terminated on one end with a norbornyl group. Grubbs' first generation catalyst polymerized macromonomers with one poly(l -lactide) chain per norbornene, and Grubbs' second generation catalyst polymerized macromonomers with two poly(l -lactide) chains per norbornene. The predicted and measured molecular weights closely matched each other, and the polydispersities of the bottlebrush polymers were between 1.05 and 1.39. These examples are the first where Grubbs' second generation catalyst can be considered living for ROMP. In the second method, the backbone was polymerized first, and polylactide arms with molecular weights from 15 000 to 50 000 g mol-1 were polymerized from the backbone. Polymers that were shaped as spheres or rigid rods were synthesized. The polymers were analyzed by GPC, MALLS, QELS, and 1H NMR.- Published
- 2004
173. The Use of Skin for the Replacement of the Anterior Cruciate Ligament in the Dog: A Review of Thirty Cases.
- Author
-
Vaughan, L. C. and Bowden, N. L. R.
- Published
- 1964
- Full Text
- View/download PDF
174. Effect of reflection from an unmatched junction on the abdominal aortic impedance1.
- Author
-
NEWMAN, D. L. and BOWDEN, N. L. R.
- Abstract
The fluid impedance of the abdominal aorta was measured in anaesthetized dogs before and during the occlusion of the central branch of the aortic/external iliac junction. Aortic impedance increased during the occlusion due to a change in the terminal impedance of the peripheral beds and an increase in reflection from the aortic junction. The higher harmonics of impedance were relatively unaffected by changes in the terminal impedance and hence the increase found for these harmonics may be attributed to reflection from the junction alone. The reflection coefficient calculated from the impedance values of the higher harmonics (> 3rd) agreed well with the theoretical value from the Womersley model of a junction set in an infinite line. [ABSTRACT FROM PUBLISHER]
- Published
- 1973
175. Pressure amplitude increase on unmatching the aortic-iliac junction of the dog1.
- Author
-
NEWMAN, D. L., GOSLING, R. G., BOWDEN, N. L. R., and KING, D. H.
- Abstract
Pressure pulses were recorded simultaneously at the aortic/external iliac junction and in the abdominal aorta of six normal dogs at a distance 7—10 cm upstream of the junction. The matched abdominal aortic equitrifurcation was then transformed, in vivo, to an unmatched equibifurcation by temporary occlusion of the central branch and the pressure recording procedure repeated. An increase in the oscillatory pressure amplitudes at the junction was observed as a result of the unmatching procedure. At the upstream site the amplitude increase was similar to the junction site for only the first two harmonics of the pressure pulse. These changes were interpreted as being due to increased reflection from the unmatched junction and alteration in the peripherally reflected pressure waves reaching the aorta. [ABSTRACT FROM PUBLISHER]
- Published
- 1973
176. Mesoscale Self-Assembly: Capillary Interactions When Positive and Negative Menisci Have Similar Amplitudes
- Author
-
Wolfe, D. B., Snead, A., Mao, C., Bowden, N. B., and Whitesides, G. M.
- Abstract
This paper describes the two-dimensional self-assembly of hexagonal plates at the interface between perfluorodecalin and water. The plates were prepared with five different permutations of hydrophobic and hydrophilic faces. The shapes and amplitudes of the menisci that form on the faces of the plates determine the magnitude of the lateral capillary forces through which they interact. The amplitudes of the menisci also influence&sbd;through their out-of-plane components&sbd;the position and orientation of the plate relative to the plane of the liquid−liquid interface. In these experiments, the plates were made of poly(dimethylsiloxane) (PDMS) (ρ = 1.05 g/cm3) containing aluminum oxide (ρ = 4.00 g/cm3); this dopant adjusted the density of the plates, the extent to which they sank into the liquid−liquid interface, and thus the structure of their menisci. The plates studied had densities of 1.05 to 1.86 g/cm3. This work complements previous papers (Bowden, N.; Choi I. S.; Grzybowski, B. A.; Whitesides, G. M. J. Am. Chem. Soc.
1999 , 121, 5373. Bowden, N.; Oliver, S. R. J.; Whitesides, G. M. J. Phys. Chem. B2000 , 104, 2714.) that examined the assembly of hexagonal plates with densities at the extremes of the range studied. By following the structures of the aggregates formed at intermediate densities, it is possible to observe the way in which the self-assembling system transitions from an aggregate of one structure to that of another. The results from these studies are relevant to the design of micrometer-sized plates capable of self-assembly.- Published
- 2003
177. Synthesis of Fluorescently Labeled Polymers and Their Use in Single-Molecule Imaging
- Author
-
Bowden, N. B., Willets, K. A., Moerner, W. E., and Waymouth, R. M.
- Abstract
A series of linear polymers labeled with one perylene diimide per polymer chain were synthesized using living free-radical polymerizations based on nitroxides. Depending on the choice of the initiator, the perylene diimide was either at the end or the middle of the polymer chain. The polymers were synthesized as homopolymers or block copolymers from butyl acrylate, styrene, isoprene, and butadiene. Poly(butadiene) labeled with a perylene diimide dye in the center of the polymer was studied using single-molecule imaging in a poly(methyl methacrylate) host. Most of the dyes remained stationary during the experiments, but approximately 5% of the dyes reoriented. The fraction of dyes reorienting was observed to be independent of pumping intensity. This system is an excellent test bed for studying the local environment of the dye and the heterogeneity of the host polymer.
- Published
- 2002
- Full Text
- View/download PDF
178. Molecule-Mimetic Chemistry and Mesoscale Self-Assembly
- Author
-
Bowden, N. B., Weck, M., Choi, I. S., and Whitesides, G. M.
- Abstract
Molecules are structured aggregates of atoms joined by chemical bonds; crystals are aggregates of molecules, interacting covalently or noncovalently. The work described in this Account uses molecules, crystals, and other forms of atomic/molecular matter to suggest principles that can be used in generating structured aggregates of millimeter-scale components, interacting through capillary interactions. The properties of these aggregates&sbd;that is, their chemistry&sbd;mimic aspects of the chemistry of molecules.
- Published
- 2001
179. Self-Assembly of Microscale Objects at a Liquid/Liquid Interface through Lateral Capillary Forces
- Author
-
Bowden, N., Arias, F., Deng, T., and Whitesides, G. M.
- Abstract
Small (100−600 μm in width) hexagonal polymeric plates with faces patterned into hydrophobic and hydrophilic regions, and interacting through lateral capillary forces, were allowed to self-assemble at the perfluorodecalin/water interface. These plates were fabricated from photoresist and patterned by shadow evaporation of gold onto selected faces. The arrays that assembled from the 100 μm objects were similar in structure to those that assembled from millimeter-sized objects with analogous patterns of hydrophobic and hydrophilic faces, but with three important differences. (i) The contribution of buoyancy forces in establishing the level at which the 100 μm objects floated relative to the interface was small compared to the contribution of the vertical capillary forces. (ii) As a result, the designs of hydrophobic edges necessary to generate menisci useful in self-assembly were different for 100 μm objects than for millimeter-sized objects. (iii) The arrays that formed from the 100 μm objects had higher densities of defects than the arrays that formed from the millimeter-sized objects; these defects reflected the increase in the strength of the capillary forces (which favored assembly) relative to the shear forces (which disrupted assembly). This work adds two new elements to the study of mesoscale self-assembly: (i) It describes a new method of fabrication of plates with faces patterned into regions of different hydrophobicity that is applicable to small (perhaps <10 μm) objects, and (ii) it describes the self-assembly of 100 μm plates made by this method into ordered arrays. The work also established the contours of the menisci on the separate 100 μm and millimeter-sized plates. The scaling of the lateral and vertical capillary forces and buoyancy forces acting on millimeter-sized objects, relative to those acting on 100 μm objects, is described.
- Published
- 2001
180. First positron cooling of antiprotons
- Author
-
Gabrielse, G., Estrada, J., Tan, J. N., Yesley, P., Bowden, N. S., Oxley, P., Roach, T., Storry, C. H., Wessels, M., and Tan, J.
- Published
- 2001
- Full Text
- View/download PDF
181. Modeling of Menisci and Capillary Forces from the Millimeter to the Micrometer Size Range
- Author
-
Grzybowski, B. A., Bowden, N., Arias, F., Yang, H., and Whitesides, G. M.
- Abstract
This paper examines lateral capillary interactions between millimeter- and sub-millimeter-sized objects floating at the interface between perfluorodecalin (PFD) and water. It describes methods&sbd;both experimental and computational&sbd;that allow the shape of the interface to be described for various geometries of the interacting objects. From these shapes, it derives the energy profiles characterizing the lateral capillary interactions. This work also demonstrates a new experimental method of imaging and studying menisci, and of studying capillary interactions between objects.
- Published
- 2001
182. Ordering of Spontaneously Formed Buckles on Planar Surfaces
- Author
-
Huck, W. T. S., Bowden, N., Onck, P., Pardoen, T., Hutchinson, J. W., and Whitesides, G. M.
- Abstract
This paper describes the spontaneous formation of patterns of aligned buckles in a thin film of gold deposited on the surface of an elastomer [poly(dimethylsiloxane), PDMS]. The surface of the elastomer is patterned photochemically into areas differing in stiffness and coefficient of thermal expansion. The gold is deposited while the surface of the patterned elastomer is warm (T ~ 100 °C). On cooling, shrinkage in the elastomer places the gold film under compressive stress. The buckles relieve this compressive stress. The distribution of stresses and buckle patterns is described during the pre- and postbuckling regimes using solutions from calculations describing a model comprising a thin stiff plate resting on a thick elastic foundation.
- Published
- 2000
183. Mesoscale Self-Assembly: Capillary Bonds and Negative Menisci
- Author
-
Bowden, N., Oliver, S. R. J., and Whitesides, G. M.
- Abstract
This paper describes the self-assembly of hexagonal plates (with 2.7 mm wide sides) at the interface between perfluorodecalin (PFD) and water. All 14 different hexagons that can be made by permuting the number and location of the hydrophobic and hydrophilic faces were examined. The plates attracted one another by lateral capillary forces involving the menisci on the hydrophilic faces. The plates were made of poly(dimethylsiloxane) (PDMS) containing aluminum oxide and had a density of 1.86 g/cm3, close to the density of PFD (ρ = 1.91 g/cm3). This work complements a previous paper (Bowden, N.; Choi, I. S.; Grzybowski, B. A.; Whitesides, G. M. J. Am. Chem. Soc.
1999 , 121, 5373) that examined the self-assembly of hexagonal plates of PDMS (ρ = 1.05 g/cm3) that had a density close to that of water, and were attracted through menisci on the hydrophobic faces. The arrays that formed from the heavy (ρ = 1.86 g/cm3) hexagons with a particular pattern of hydrophilic faces were analogous to the arrays that formed from the light (ρ = 1.05 g/cm3) hexagons with that pattern of hydrophobic faces.- Published
- 2000
184. The assessment of potential attractants to beetle pests: improvements to laboratory pitfall bioassay methods
- Author
-
Morgan, C., Sherington, J., Gudrups, I., and Bowden, N. S.
- Published
- 1998
- Full Text
- View/download PDF
185. The area ratio of normal aortic junctions
- Author
-
Gosling, R. G., Newman, D. L., Bowden, N. L. R., and Twinn, K.W.
- Abstract
In this investigation the area ratio of the abdominal aortic junction in three species—chicken, dog and man—is measured and compared with the area ratio which theoretically gives minimum reflection of the pressure pulse at this junction. It is shown that in the cockerel and the dog the abdominal aortic junction has an area ratio close to the theoretically expected value. In man, however, it is found that this is true only in infancy and that the junction becomes progressively “mismatched” with age.
- Published
- 1971
- Full Text
- View/download PDF
186. Gonadal Steroids and Aggressive Behaviour in Male and Female Rats.
- Author
-
Bowden, N., N. E.van de Poll, N., van Oyen, J. G., Brain, P. F., and Swanson, H. H.
- Subjects
- *
STEROID hormones , *ANIMAL aggression , *ENDOCRINOLOGY , *ANIMAL sexual behavior , *TESTOSTERONE , *ESTRADIOL benzoate - Abstract
The present study investigated the activating effects of steroid hormones upon aggression and sexual behavior in male and female S3 strain mice. Groups of gonadectomized male and female rats were treated with testosterone propionate (TP) or oestradiol benzoate (EB). Analysis of variance indicated that the overall effects of TP- or EB-treatment were significantly different in the two sexes. In females, aggression was higher in TP-treated than in EB-treated animals or oil-treated controls. EB and TP were equally efficacious in males. The responses of EB-treated females to TP-treated opponents are of special interest as female-typical sexual responses were frequent and aggression relatively low but not absent.
- Published
- 1982
- Full Text
- View/download PDF
187. Letters to the Editor.
- Author
-
Bowden, N. L. R., Thoday, Keith L., and Evans, J. G.
- Published
- 1972
- Full Text
- View/download PDF
188. A low mass optical grid for the PROSPECT reactor antineutrino detector.
- Author
-
Ashenfelter, J., Balantekin, A. B., Band, H. R., Bass, C. D., Bergeron, D. E., Berish, D., Bowden, N. S., Brodsky, J. P., Bryan, C. D., Cherwinka, J. J., Classen, T., Conant, A. J., Davee, D., Dean, D., Deichert, G., Detweiler, A. E., Diwan, M. V., Dolinski, M. J., Erickson, A., and Febbraro, M.
- Published
- 2019
- Full Text
- View/download PDF
189. Lithium-loaded liquid scintillator production for the PROSPECT experiment.
- Author
-
Ashenfelter, J., Balantekin, A. B., Band, H. R., Bass, C. D., Bergeron, D. E., Berish, D., Bignell, L. J., Bowden, N. S., Brodsky, J. P., Bryan, C. D., Reyes, C. Camilo, Campos, S., Cherwinka, J. J., Classen, T., Conant, A. J., Davee, D., Dean, D., Deichert, G., Perez, R. Diaz, and Diwan, M. V.
- Published
- 2019
- Full Text
- View/download PDF
190. Synthesis of Polyethylene Graft Block Copolymers from Styrene, Butyl Acrylate, and Butadiene
- Author
-
Bowden, N. B., Dankova, M., Wiyatno, W., Hawker, C. J., and Waymouth, R. M.
- Published
- 2002
- Full Text
- View/download PDF
191. Gene Expression Profiling in Familial Adenomatous Polyposis Adenomas and Desmoid Disease
- Author
-
Bowden Nikola A, Croft Amanda, and Scott Rodney J
- Subjects
gene expression profiling ,FAP ,adenomos ,desmoid tumours ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Genetics ,QH426-470 - Abstract
Abstract Gene expression profiling is a powerful method by which alterations in gene expression can be interrogated in a single experiment. The disease familial adenomatous polyposis (FAP) is associated with germline mutations in the APC gene, which result in aberrant β-catenin control. The molecular mechanisms underlying colorectal cancer development in FAP are being characterised but limited information is available about other symptoms that occur in this disorder. Although extremely rare in the general population, desmoid tumours in approximately 10% of FAP patients. The aim of this study was to determine the similarities and differences in gene expression profiles in adenomas and compare them to those observed in desmoid tumours. Illumina whole genome gene expression BeadChips were used to measure gene expression in FAP adenomas and desmoid tumours. Similarities between gene expression profiles and mechanisms important in regulating formation of FAP adenomas and desmoid tumours were identified. This study furthers our understanding of the mechanisms underlying FAP and desmoid tumour formation.
- Published
- 2007
- Full Text
- View/download PDF
192. Note on arXiv:2005.05301, 'Preparation of the Neutrino-4 experiment on search for sterile neutrino and the obtained results of measurements'
- Author
-
Andriamirado, M., Balantekin, A. B., Band, H. R., Bass, C. D., Bergeron, D. E., Berish, D., Bowden, N. S., Brodsky, J. P., Bryan, C. D., Classen, T., Conant, A. J., Deichert, G., Diwan, M. V., Dolinski, M. J., Erickson, A., Foust, B. T., Gaison, J. K., Galindo-Uribarri, A., Gilbert, C. E., Hackett, B. T., Hans, S., Hansell, A. B., Heeger, K. M., Jaffe, D. E., Ji, X., Jones, D. C., Kyzylova, O., Lane, C. E., Langford, T. J., Larosa, J., Littlejohn, B. R., Lu, X., Maricic, J., Mendenhall, M. P., Meyer, A. M., Milincic, R., Mitchell, I., Mueller, P. E., Mumm, H. P., Napolitano, J., Nave, C., Neilson, R., Nikkel, J. A., Norcini, D., Nour, S., Palomino-Gallo, J. L., Pushin, D. A., Qian, X., Romero-Romero, E., Rosero, R., Surukuchi, P. T., Tyra, M. A., Varner, R. L., Venegas-Vargas, D., Weatherly, P. B., White, C., Wilhelmi, J., Woolverton, A., Yeh, M., Zhang, A., Zhang, C., Zhang, X., Almazan, H., Bonhomme, A., Buck, C., Del Amo Sanchez, P., El Atmani, I., Labit, L., Lamblin, J., Letourneau, A., Lhuillier, D., Matthieu Licciardi, Materna, T., Pessard, H., Real, J. -S, Roca, C., Rogly, R., Savu, V., Schoppmann, S., Soldner, T., Stutz, A., Vialat, M., Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Institut Laue-Langevin (ILL), ILL, PROSPECT, and STEREO
- Subjects
neutrino: sterile: search for ,data analysis method ,FOS: Physical sciences ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,High Energy Physics - Experiment ,coherence ,High Energy Physics - Experiment (hep-ex) ,statistical analysis ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,neutrino: oscillation ,Nuclear Experiment (nucl-ex) ,numerical calculations: Monte Carlo ,Nuclear Experiment ,signature - Abstract
We comment on the claimed observation [arXiv:arXiv:2005.05301] of sterile neutrino oscillations by the Neutrino-4 collaboration. Such a claim, which requires the existence of a new fundamental particle, demands a level of rigor commensurate with its impact. The burden lies with the Neutrino-4 collaboration to provide the information necessary to prove the validity of their claim to the community. In this note, we describe aspects of both the data and analysis method that might lead to an oscillation signature arising from a null experiment and describe additional information needed from the Neutrino-4 collaboration to support the oscillation claim. Additionally, as opposed to the assertion made by the Neutrino-4 collaboration, we also show that the method of 'coherent summation' using the $L/E$ parameter produces similar results to the methods used by the PROSPECT and the STEREO collaborations., Comment: 5 pages, 3 figures
193. Double Chooz: A Search for the neutrino mixing angle theta(13)
- Author
-
Ardellier, F., Barabanov, I., Barriere, J. C., Beiel, F., Berridge, S., Bezrukov, Leonid B., Bernstein, A., Bolton, T., Bowden, N. S., Buck, Ch, Bugg, B., Busenitz, J., Cabrera, A., Caden, E., Cattadori, C., Cazaux, S., Cerrada, M., Chevis, B., Cohn, H., Coleman, J., Cormon, S., Courty, B., Cucoanes, A., Cribier, M., Danilov, N., Dazeley, S., Vacri, A. Di, Efremenko, Y., Etenko, A., Fallot, M., Fernandez-Bedoya, C., Feilitzsch, F., Foucher, Y., Gabriel, T., Ghislain, P., Botella, I. Gil, Giurgiu, G., Goeger-Neff, M., Goodman, M., Greiner, D., Grieb, Ch, Guarino, V., Guertin, A., Guillouet, P., Hagner, C., Hampel, W., Handler, T., Hartmann, F. X., Horton-Smith, G., Huber, P., Jochum, J., Kamyshkov, Y., Kaplan, D. M., Kerret, H., Kirchner, T., Kopeikin, V., Kopp, Joachim, Kozlov, A., Kutter, T., Krylov, Yu S., Kryn, D., Lachenmaier, T., Lane, C., Lasserre, T., Lendvai, C., Liu, Y., Letourneau, A., Lhuillier, D., Lindner, M., Losecco, J., Machulin, I., Marie, F., Martino, J., Mckee, D., Mcneil, R., Meigner, F., Mention, G., Metcalf, W., Mikaelyan, L., Milsztajn, A., Meyer, J. P., Motta, D., Oberauer, L., Obolensky, M., Palomares, C., Perrin, P., Potzel, W., Reichenbacher, J., Reinhold, B., Reyna, D., Rolinec, M., Romero, L., Stefan Roth, Schonert, Stefan, Schwan, U., Schwetz, T., Scola, L., Sinev, V., Skorokhvatov, M., Stahl, A., Stancu, I., Stanton, N., Sukhotin, S., Svoboda, R., Tang, A., Tonazzo, A., Underwood, D., Valdivia, F. J., Vignaud, D., Vincent, D., Winter, W., Zbiri, K., Zimmermann, R., Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Double-CHOOZ, Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)
- Subjects
High Energy Physics - Experiment (hep-ex) ,Physics::Instrumentation and Detectors ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,FOS: Physical sciences ,High Energy Physics::Experiment ,High Energy Physics - Experiment - Abstract
The Double Chooz Reactor Neutrino Experiment in France plans to quickly measure the neutrino mixing angle theta-13, or limit it to sin^2 2-theta_13 less than 0.025. The physics reach, experimental site, detector structures, scintillator, photodetection, electronics, calibration and simulations are described. The possibility of using Double Chooz to explore the possible use of a antineutrino detector for non-proliferation goals is also presented., Comment: Double Chooz Collaboration Description of planned reactor neutrino experiment. 162 pages, 106 figures, 113 authors from 24 institutions Revision fixes typos in simulation, electronics and photomultiplier chapters
194. Planning the Future of U.S. Particle Physics (Snowmass 2013): Chapter 8: Instrumentation Frontier
- Author
-
Demarteau, M., Lipton, R., Nicholson, H., Shipsey, I., Akerib, D., Albayrak-Yetkin, A., Alexander, J., Anderson, J., Artuso, M., Asner, D., Ball, R., Battaglia, M., Bebek, C., Beene, J., Benhammou, Y., Bentefour, E., Bergevin, M., Bernstein, A., Bilki, B., Blucher, E., Bolla, G., Bortoletto, D., Bowden, N., Brooijmans, G., Byrum, K., Cabrera, B., Cancelo, G., Carlstrom, J., Casey, B., Chang, C., Chapman, J., Chen, C. H., Childres, I., Christian, D., Convery, M., Corso, W. Cooper J., Cumalat, J., Cushman, P., Da Via, C., Dazeley, S., Debbins, P., Deptuch, G., Dhawan, S., Di Benedetto, V., Digiovene, B., Djurcic, Z., Dye, S., Elagin, A., Estrada, J., Evans, H., Etzion, E., Fast, J., Ferretti, C., Fisher, P., Fleming, B., Francis, K., Friedman, P., Frisch, H., Garcia-Sciveres, M., Gatto, C., Geronim, G., Gilchriese, G., Golwala, S., Grant, C., Grillo, A., Grünendahl, E., Gorham, P., Guan, L., Gutierrez, G., Haber, C., Hall, J., Haller, G., Hast, C., Heintz, U., Hemmick, T., Hitlin, D. G., Hogan, C., Hohlmann, M., Hoppe, E., Hsu, L., Huffer, M., Irwin, K., Izraelevitch, F., Jennings, G., Johnson, M., Jung, A., Kagan, H., Kenney, C., Kettell, S., Khanna, R., Khristenko, V., Krennrich, F., Kuehn, K., Kutschke, R., Learned, J., Lee, A. T., Levin, D., Liu, T., Liu, A. T. K., Lissauer, D., Love, J., Lynn, D., Macfarlane, D., Magill, S., Majewski, S., Mans, J., Maricic, J., Marleau, P., Mazzacane, A., Mckinsey, D., Mehl, J., Mestvirisvilli, A., Meyer, S., Mokhov, N., Moshe, M., Mukherjee, A., Murat, P., Nahn, S., Narain, M., Nadel-Turonski, P., Newcomer, M., Nishimura, K., Nygren, D., Oberla, E., Onel, Y., Oreglia, M., Orrell, J., Paley, J., Para, A., Parker, S., Polychronakos, V., Pordes, S., Privitera, P., Prosser, A., Pyle, M., Raaf, J., Ramberg, E., Rameika, R., Brian Rebel, Repond, J., Reyna, D., Ristori, L., Rivera, R., Ronzhin, A., Rusack, R., Russ, J., Ryd, A., Sadrozinski, H., Sahoo, H., Sanchez, M. C., Sanzeni, C., Schnetzer, S., Seidel, S., Seiden, A., Schmidt, I., Shenai, A., Shutt, T., Silver, Y., Smith, W., Snowden-Ifft, D., Sonnenschein, A., Southwick, D., Spiegel, L., Stanitzki, M., Striganov, S., Su, D., Sumner, R., Svoboda, R., Sweany, M., Talaga, R., Tayloe, R., Tentindo, S., Terentiev, N., Thom-Levy, J., Thorn, C., Tiffenberg, J., Trischuk, W., Tschirhart, R., Turner, M., Underwood, D., Uplegger, L., Urheim, J., Vagins, M., Bibber, K., Varner, G., Varner, R., Va Vra, J., Lippe, H., Wagner, R., Wagner, S., Weaverdyck, C., Wenzel, H., Weinstein, A., Wetstein, M., White, A., Wigman, R., Wilson, P., Winn, D., Winter, P., Woody, C., Xia, L., Xie, J. Q., Ye, Z., Yeh, M. F., Yetkin, T., Yoo, J. H., Yu, J., Yu, J. M., Zeller, S., Zhang, J. L., Zhu, J. J., Zhou, B., Zhu, R. Y., and Zitzer, B.
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Experiment (hep-ex) ,Physics - Instrumentation and Detectors ,High Energy Physics - Phenomenology (hep-ph) ,hep-ex ,FOS: Physical sciences ,hep-ph ,Instrumentation and Detectors (physics.ins-det) ,physics.ins-det ,High Energy Physics - Experiment - Abstract
These reports present the results of the 2013 Community Summer Study of the APS Division of Particles and Fields ("Snowmass 2013") on the future program of particle physics in the U.S. Chapter 8, on the Instrumentation Frontier, discusses the instrumentation needs of future experiments in the Energy, Intensity, and Cosmic Frontiers, promising new technologies for particle physics research, and issues of gathering resources for long-term research in this area., Comment: 50 pages
195. Time projection chamber for directional fast neutron detection
- Author
-
Jovanovic, I., Bowden, N. S., Carosi, G. P., Michael Heffner, and Roecker, C.
196. Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase
- Author
-
Hsiao, S.T., Spencer, T., Boldock, L., Prosseda, S.D., Xanthis, I., Tovar-Lopez, F.J., van Buesekamp, H., Khamis, R.Y., Foin, N., Bowden, N., Hussain, A., Rothman, A., Ridger, V., Halliday, I., Perrault, C., Gunn, J., Evans, P.C., and Cardiology
- Subjects
Shear stress ,surgical procedures, operative ,Cardiovascular System & Hematology ,Endothelial cells ,Fasudil ,ROCK ,Stent ,cardiovascular diseases ,equipment and supplies ,1102 Cardiovascular Medicine And Haematology - Abstract
Aims: Stent deployment causes endothelial cell (EC) denudation, which promotes in-stent restenosis and thrombosis. Thus endothelial regrowth in stented arteries is an important therapeutic goal. Stent struts modify local hemodynamics, however the effects of flow pertubation on EC injury and repair are incompletely understood. By studying the effects of stent struts on flow and EC migration we identified an intervention that promotes endothelial repair in stented arteries.\ud Methods and Results: In vitro and in vivo models were developed to monitor endothelialization under flow and the influence of stent struts. A 2D parallel-plate flow chamber with 100 μm ridges arranged perpendicular to the flow was used. Live cell imaging coupled to computational fluid dynamic simulations revealed that EC migrate in the direction of flow upstream from the ridges but subsequently accumulate downstream from ridges at sites of bidirectional flow. The mechanism of EC trapping by bidirectional flow involved reduced migratory polarity associated with altered actin dynamics. Inhibition of Rho-associated protein kinase (ROCK) enhanced endothelialization of ridged surfaces by promoting migratory polarity under bidirectional flow (p
197. Aboveground antineutrino detectors for reactor monitoring and safeguards
- Author
-
Kiff, S., Bernstein, A., Bowden, N., Cabrera-Palmer, B., Dazeley, S., Gregory Keefer, and Reyna, D.
198. The Intermediate Neutrino Program
- Author
-
Adams, C., Alonso, J. R., Ankowski, A. M., Asaadi, J. A., Ashenfelter, J., Axani, S. N., Babu, K., Backhouse, C., Band, H. R., Barbeau, P. S., Barros, N., Bernstein, A., Betancourt, M., Bishai, M., Blucher, E., Bouffard, J., Bowden, N., Brice, S., Bryan, C., Camilleri, L., Cao, J., Carlson, J., Carr, R. E., Chatterjee, A., Chen, M., Chen, S., Chiu, M., Church, E. D., Collar, J. I., Collin, G., Conrad, J. M., Convery, M. R., Cooper, R. L., Cowen, D., Davoudiasl, H., Gouvea, A., Dean, D. J., Deichert, G., Descamps, F., Deyoung, T., Diwan, M. V., Djurcic, Z., Dolinski, M. J., Dolph, J., Donnelly, B., Dwyer, D. A., Dytman, S., Efremenko, Y., Lisa Everett, Fava, A., Figueroa-Feliciano, E., Fleming, B., Friedland, A., Fujikawa, B. K., Gaisser, T. K., Galeazzi, M., Galehouse, D. C., Galindo-Uribarri, A., Garvey, G. T., Gautam, S., Gilje, K. E., Gonzalez-Garcia, M., Goodman, M. C., Gordon, H., Gramellini, E., Green, M. P., Guglielmi, A., Hackenburg, R. W., Hackenburg, A., Halzen, F., Han, K., Hans, S., Harris, D., Heeger, K. M., Herman, M., Hill, R., Holin, A., Huber, P., Jaffe, D. E., Johnson, R. A., Joshi, J., Karagiorgi, G., Kaufman, L. J., Kayser, B., Kettell, S. H., Kirby, B. J., Klein, J. R., Kolomensky, Yu G., Kriske, R. M., Lane, C. E., Langford, T. J., Lankford, A., Lau, K., Learned, J. G., Ling, J., Link, J. M., Lissauer, D., Littenberg, L., Littlejohn, B. R., Lockwitz, S., Lokajicek, M., Louis, W. C., Luk, K., Lykken, J., Marciano, W. J., Maricic, J., Markoff, D. M., Martinez Caicedo, D. A., Mauger, C., Mavrokoridis, K., Mccluskey, E., Mckeen, D., Mckeown, R., Mills, G., Mocioiu, I., Monreal, B., Mooney, M. R., Morfin, J. G., Mumm, P., Napolitano, J., Neilson, R., Nelson, J. K., Nessi, M., Norcini, D., Nova, F., Nygren, D. R., Orebi Gann, G. D., Palamara, O., Parsa, Z., Patterson, R., Paul, P., Pocar, A., Qian, X., Raaf, J. L., Rameika, R., Ranucci, G., Ray, H., Reyna, D., Rich, G. C., Rodrigues, P., Romero, E. Romero, Rosero, R., Rountree, S. D., Rybolt, B., Sanchez, M. C., Santucci, G., Schmitz, D., Scholberg, K., Seckel, D., Shaevitz, M., Shrock, R., Smy, M. B., Soderberg, M., Sonzogni, A., Sousa, A. B., Spitz, J., St John, J. M., Stewart, J., Strait, J. B., Sullivan, G., Svoboda, R., Szelc, A. M., Tayloe, R., Thomson, M. A., Toups, M., Vacheret, A., Vagins, M., Water, R. G., Vogelaar, R. B., Weber, M., Weng, W., Wetstein, M., White, C., White, B. R., Whitehead, L., Whittington, D. W., Wilking, M. J., Wilson, R. J., Wilson, P., Winklehner, D., Winn, D. R., Worcester, E., Yang, L., Yeh, M., Yokley, Z. W., Yoo, J., Yu, B., Yu, J., Zhang, C., and Physics
- Subjects
Physics - Instrumentation and Detectors ,Physics::Instrumentation and Detectors ,hep-ex ,Astrophysics::High Energy Astrophysical Phenomena ,High Energy Physics::Phenomenology ,FOS: Physical sciences ,Instrumentation and Detectors (physics.ins-det) ,nucl-ex ,High Energy Physics - Experiment ,High Energy Physics - Experiment (hep-ex) ,High Energy Physics::Experiment ,Nuclear Experiment (nucl-ex) ,Nuclear Experiment ,physics.ins-det ,Particle Physics - Experiment - Abstract
The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program (WINP) at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop., pdfLaTeX, 31 pages, 1 figure, minor modification to 0nuBB discussion
199. New biodegradable polymers based on previously unknown functional groups for drug and gene delivery
- Author
-
Yoo, J., Graf, T. A., DENISON KURUVILLA, D Mello, S. R., Salem, A. K., and Bowden, N. B.
200. Working Group Report: Neutrinos
- Author
-
Gouvea, A., Pitts, K., Scholberg, K., Zeller, G. P., Alonso, J., Bernstein, A., Bishai, M., Elliott, S., Heeger, K., Hoffman, K., Huber, P., Kaufman, L. J., Kayser, B., Link, J., Lunardini, C., Monreal, B., Morfin, J. G., Robertson, H., Tayloe, R., Tolich, N., Abazajian, K., Akiri, T., Albright, C., Asaadi, J., Babu, K. S., Balantekin, A. B., Barbeau, P., Bass, M., Blake, A., Blondel, A., Blucher, E., Bowden, N., Brice, S. J., Bross, A., Carls, B., Cavanna, F., Choudhary, B., Coloma, P., Connolly, A., Conrad, J., Convery, M., Cooper, R. L., Cowen, D., Da Motta, H., Young, T., Di Lodovico, F., Diwan, M., Djurcic, Z., Dracos, M., Dodelson, S., Efremenko, Y., Ekelof, T., Feng, J. L., Fleming, B., Formaggio, J., Friedland, A., Fuller, G., Gallagher, H., Geer, S., Gilchriese, M., Goodman, M., Grant, D., Gratta, G., Hall, C., Halzen, F., Harris, D., Heffner, M., Henning, R., Hewett, J. L., Hill, R., Himmel, A., Horton-Smith, G., Karle, A., Katori, T., Kearns, E., Kettell, S., Klein, J., Kim, Y., Kim, Y. K., Kolomensky, Yu, Kordosky, M., Kudenko, Yu, Kudryavtsev, V. A., Lande, K., Lang, K., Lanza, R., Lau, K., Lee, H., Li, Z., Littlejohn, B. R., Lin, C. J., Liu, D., Liu, H., Long, K., Louis, W., Luk, K. B., Marciano, W., Mariani, C., Marshak, M., Mauger, C., Mcdonald, K. T., Mcfarland, K., Mckeown, R., Messier, M., Mishra, S. R., Mosel, U., Mumm, P., Nakaya, T., Nelson, J. K., Nygren, D., Orebi Gann, G. D., Osta, J., Palamara, O., Paley, J., Papadimitriou, V., Parke, S., Parsa, Z., Patterson, R., Piepke, A., Plunkett, R., Poon, A., Xin Qian, Raaf, J., Rameika, R., Ramsey-Musolf, M., Rebel, B., Roser, R., Rosner, J., Rott, C., Rybka, G., Sahoo, H., Sangiorgio, S., Schmitz, D., Shrock, R., Shaevitz, M., Smith, N., Smy, M., Sobel, H., Sorensen, P., Sousa, A., Spitz, J., Strauss, T., Svoboda, R., Tanaka, H. A., Thomas, J., Tian, X., Tschirhart, R., Tully, C., Bibber, K., Water, R. G., Vahle, P., Vogel, P., Walter, C. W., Wark, D., Wascko, M., Webber, D., Weerts, H., White, C., White, H., Whitehead, L., Wilson, R. J., Winslow, L., Wongjirad, T., Worcester, E., Yokoyama, M., Yoo, J., and Zimmerman, E. D.
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.