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155. Switch from sequestering to anti-CD20 depleting treatment: disease activity outcomes during wash-out and in the first 6 months of ocrelizumab therapy

Author

Signoriello, Elisabetta, primary, Lus, Giacomo, additional, Bonavita, Simona, additional, Lanzillo, Roberta, additional, Saccà, Francesco, additional, Landi, Doriana, additional, Frau, Jessica, additional, Baroncini, Damiano, additional, Zaffaroni, Mauro, additional, Maniscalco, Giorgia Teresa, additional, Curti, Erica, additional, Sartori, Arianna, additional, Cepparulo, Simone, additional, Marfia, Girolama Alessandra, additional, Nicoletti, Carolina Gabri, additional, Carotenuto, Antonio, additional, Nociti, Viviana, additional, Caleri, Francesca, additional, Sormani, Maria Pia, additional, and Signori, Alessio, additional

Published
2021
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156. Public Engagement and Neurology: An Update

Author

Lavorgna, Luigi, primary, Brigo, Francesco, additional, Esposito, Sabrina, additional, Abbadessa, Gianmarco, additional, Sparaco, Maddalena, additional, Lanzillo, Roberta, additional, Moccia, Marcello, additional, Inglese, Matilde, additional, Bonfanti, Luca, additional, Trojsi, Francesca, additional, Spina, Emanuele, additional, Russo, Antonio, additional, De Micco, Pasquale, additional, Clerico, Marinella, additional, Tedeschi, Gioacchino, additional, and Bonavita, Simona, additional

Published
2021
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157. Physical Exercise Moderates the Effects of Disability on Depression in People with Multiple Sclerosis during the COVID-19 Outbreak

Author

Carotenuto, Antonio, primary, Scandurra, Cristiano, additional, Costabile, Teresa, additional, Lavorgna, Luigi, additional, Borriello, Giovanna, additional, Moiola, Lucia, additional, Inglese, Matilde, additional, Trojsi, Francesca, additional, Petruzzo, Martina, additional, Ianniello, Antonio, additional, Nozzolillo, Agostino, additional, Cellerino, Maria, additional, Boffa, Giacomo, additional, Rosa, Laura, additional, Chiodi, Alessandro, additional, Servillo, Giuseppe, additional, Moccia, Marcello, additional, Bonavita, Simona, additional, Filippi, Massimo, additional, Petracca, Maria, additional, Brescia Morra, Vincenzo, additional, and Lanzillo, Roberta, additional

Published
2021
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160. Sex effects across the lifespan in women with multiple sclerosis

Author

Altıntaş, Ayşe (ORCID 0000-0002-8524-5087 & YÖK ID 11611), Krysko, Kristen M.; Graves, Jennifer S.; Dobson, Ruth; Amato, Maria Pia; Bernard, Jacqueline; Bonavita, Simona; Bove, Riley; Cavalla, Paola; Clerico, Marinella; Corona, Teresa; Doshi, Anisha; Fragoso, Yara; Jacobs, Dina; Jokubaitis, Vilija; Landi, Doriana; Llamosa, Gloria; Longbrake, Erin E.; Maillart, Elisabeth; Marta, Monica; Midaglia, Luciana; Shah, Suma; Tintore, Mar; van der Walt, Anneke; Voskuhl, Rhonda; Wang, Yujie; Zabad, Rana K.; Zeydan, Burcu; Houtchens, Maria; Hellwig, Kerstin, School of Medicine, Altıntaş, Ayşe (ORCID 0000-0002-8524-5087 & YÖK ID 11611), Krysko, Kristen M.; Graves, Jennifer S.; Dobson, Ruth; Amato, Maria Pia; Bernard, Jacqueline; Bonavita, Simona; Bove, Riley; Cavalla, Paola; Clerico, Marinella; Corona, Teresa; Doshi, Anisha; Fragoso, Yara; Jacobs, Dina; Jokubaitis, Vilija; Landi, Doriana; Llamosa, Gloria; Longbrake, Erin E.; Maillart, Elisabeth; Marta, Monica; Midaglia, Luciana; Shah, Suma; Tintore, Mar; van der Walt, Anneke; Voskuhl, Rhonda; Wang, Yujie; Zabad, Rana K.; Zeydan, Burcu; Houtchens, Maria; Hellwig, Kerstin, and School of Medicine

Abstract

Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating central nervous system disorder that is more common in women, with onset often during reproductive years. The female:male sex ratio of MS rose in several regions over the last century, suggesting a possible sex by environmental interaction increasing MS risk in women. Since many with MS are in their childbearing years, family planning, including contraceptive and disease-modifying therapy (DMT) counselling, are important aspects of MS care in women. While some DMTs are likely harmful to the developing fetus, others can be used shortly before or until pregnancy is confirmed. Overall, pregnancy decreases risk of MS relapses, whereas relapse risk may increase postpartum, although pregnancy does not appear to be harmful for long-term prognosis of MS. However, ovarian aging may contribute to disability progression in women with MS. Here, we review sex effects across the lifespan in women with MS, including the effect of sex on MS susceptibility, effects of pregnancy on MS disease activity, and management strategies around pregnancy, including risks associated with DMT use before and during pregnancy, and while breastfeeding. We also review reproductive aging and sexual dysfunction in women with MS., Sylvia Lawry Physician Fellowship, National Multiple Sclerosis Society

Published
2020

161. Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability

Author

Tedeschi, Gioacchino, Dinacci, Daria, Lavorgna, Luigi, Prinster, Anna, Savettieri, Giovanni, Quattrone, Aldo, Livrea, Paolo, Messina, Corrado, Reggio, Arturo, Servillo, Giovanna, Bresciamorra, Vincenzo, Orefice, Giuseppe, Paciello, Marcantonio, Brunetti, Arturo, Paolillo, Andrea, Coniglio, Gabriella, Bonavita, Simona, Di Costanzo, Alfonso, Bellacosa, Alessandra, Valentino, Paola, Quarantelli, Mario, Patti, Francesco, Salemi, Giuseppe, Cammarata, Enrico, Simone, Isabella, Salvatore, Marco, Bonavita, Vincenzo, and Alfano, Bruno

Published
2007
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165. Digital work engagement among Italian neurologists

Author

Brigo, Francesco, primary, Ponzano, Marta, additional, Sormani, Maria Pia, additional, Clerico, Marinella, additional, Abbadessa, Gianmarco, additional, Cossu, Giovanni, additional, Trojsi, Francesca, additional, Colucci, Fabiana, additional, Tortorella, Carla, additional, Miele, Giuseppina, additional, Spina, Emanuele, additional, Artusi, Carlo Alberto, additional, Carmisciano, Luca, additional, Servillo, Giovanna, additional, Bozzali, Marco, additional, Sparaco, Maddalena, additional, Leocani, Letizia, additional, Lanzillo, Roberta, additional, Tedeschi, Gioacchino, additional, Bonavita, Simona, additional, and Lavorgna, Luigi, additional

Published
2021
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166. Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis

Author

Savettieri, Giovanni, Messina, Demetrio, Andreoli, Virginia, Bonavita, Simona, Caltagirone, Carlo, Cittadella, Rita, Farina, Deborah, Fazio, Maria Carolina, Girlanda, Paolo, Le Pira, Francesco, Liguori, Maria, Lugaresi, Alessandra, Nocentini, Ugo, Reggio, Arturo, Salemi, Giuseppe, Tedeschi, Gioacchino, Trojano, Maria, Valentino, Paola, and Quattrone, Aldo

Published
2004
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168. COVID‐19 pandemic and mental distress in multiple sclerosis: Implications for clinical management

Author

Costabile, Teresa, primary, Carotenuto, Antonio, additional, Lavorgna, Luigi, additional, Borriello, Giovanna, additional, Moiola, Lucia, additional, Inglese, Matilde, additional, Petruzzo, Martina, additional, Trojsi, Francesca, additional, Ianniello, Antonio, additional, Nozzolillo, Agostino, additional, Cellerino, Maria, additional, Boffa, Giacomo, additional, Rosa, Laura, additional, Servillo, Giuseppe, additional, Moccia, Marcello, additional, Bonavita, Simona, additional, Filippi, Massimo, additional, Lanzillo, Roberta, additional, Brescia Morra, Vincenzo, additional, and Petracca, Maria, additional

Published
2020
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171. Apolipoprotein E genotype does not influence the progression of multiple sclerosis

Author

Savettieri, Giovanni, Andreoli, Virginia, Bonavita, Simona, Cittadella, Rita, Caltagirone, Carlo, Fazio, Maria Carolina, Girlanda, Paolo, Pira, Francesco, Liguori, Maria, Logroscino, Giancarlo, Lugaresi, Alessandra, Nocentini, Ugo, Reggio, Arturo, Salemi, Giuseppe, Serra, Paolo, Tedeschi, Gioacchino, Toma, Lucia, Trojano, Maria, Valentino, Paola, and Quattrone, Aldo

Subjects
Apolipoproteins -- Research, Multiple sclerosis -- Development and progression, Multiple sclerosis -- Research, Genetic polymorphisms -- Research, Health
Abstract

Byline: Giovanni Savettieri (1), Virginia Andreoli (2), Simona Bonavita (3), Rita Cittadella (2), Carlo Caltagirone (4), Maria Carolina Fazio (5), Paolo Girlanda (5), Francesco Pira (6), Maria Liguori (7), Giancarlo Logroscino (8), Alessandra Lugaresi (9), Ugo Nocentini (4), Arturo Reggio (6), Giuseppe Salemi (1), Paolo Serra (2), Gioacchino Tedeschi (3), Lucia Toma (9), Maria Trojano (7), Paola Valentino (10), Aldo Quattrone (2,10,11) Keywords: multiple sclerosis; APOE polymorphism; APOE promoter; MS progression Abstract: Objective: To investigate the association between apolipoprotein E (APOE) polymorphisms and the progression of MS. Methods: We investigated 428 subjects affected by clinically defined MS, with a disease duration of at least three years. We collected data concerning the age at onset of MS, clinical type, disease duration and disability according to the expanded disability status scale (EDSS). We also calculated the progression index (PI) to evaluate disease progression. APOE genotyping and the --491 A/T polymorphism of the APOE promoter were determined. Results: No association was observed between the APOE [epsilon]4 allele and clinical characteristics of our study population. We also investigated the --491 A/T APOE promoter polymorphism in 236 MS subjects and did not find any association between the --491 A/T polymorphism and the selected clinical variables. Conclusions: In our population the APOE [epsilon]4 allele and the --491 A/T APOE promoter polymorphism are not associated with a more rapid course of MS. Author Affiliation: (1) Institute of Neuropsychiatry, University of Palermo, Palermo, Italy (2) Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone (Cosenza), Italy (3) Dept. of Neurological Sciences, 2nd University of Naples, Naples, Italy (4) Cattedra di Neurologia and I.R.C.C.S., Fondazione 'S. Lucia', University of Rome 'Tor Vergata', Rome, Italy (5) Dept. of Neurosciences, Psychiatry and Anaesthesiology, University of Messina, Messina, Italy (6) Dept. of Neurological Sciences, University of Catania, Catania, Italy (7) Dept. of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy (8) Dept. of Neurology, Ospedale Miulli, Bari, Italy (9) Dept. of Oncology &amp Neuroscience, University of Chieti 'Gabriele d'Annunzio', Chieti, Italy (10) Institute of Neurology, University Magna Graecia, Catanzaro, Italy (11) Clinica Neurologica, Policlinico Mater Domini, Via T. Campanella, 88100, Catanzaro, Italy Article History: Received Date: 10/10/2002 Accepted Date: 08/05/2003

Published
2003

172. Identification of Covid-19 suspect cases through a digital triage: a multicenter Italian-Iranian study on

Author

Abbadessa, Gianmarco, primary, Sparaco, Maddalena, additional, Ghajarzadeh, Mahsa, additional, Cavalla, Paola, additional, Signoriello, Elisabetta, additional, Valentino, Paola, additional, Borriello, Giovanna, additional, Clerico, Marinella, additional, Lanzillo, Roberta, additional, Lavorgna, Luigi, additional, Martino, Antonio De, additional, Mirmosayyeb, Omid, additional, Shaygannejad, Vahid, additional, Fratta, Mario, additional, Lus, Giacomo, additional, and Bonavita, Simona, additional

Published
2020
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173. The Rise of the GRN C157KfsX97 Mutation in Southern Italy: Going Back to the Fall of the Western Roman Empire

Author

Coppola, Cinzia, primary, Saracino, Dario, additional, Oliva, Mariano, additional, Puoti, Gianfranco, additional, Lus, Giacomo, additional, Le Ber, Isabelle, additional, Pariente, Jérémie, additional, Tessitore, Alessandro, additional, Benussi, Luisa, additional, Ghidoni, Roberta, additional, Carrara, Matteo, additional, Ricci, Martina, additional, Redaelli, Veronica, additional, Tiraboschi, Pietro, additional, Caroppo, Paola, additional, Giaccone, Giorgio, additional, Bonavita, Simona, additional, and Rossi, Giacomina, additional

Published
2020
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174. Hippocampal connectivity in Amyotrophic Lateral Sclerosis (ALS): more than Papez circuit impairment

Author

Trojsi, Francesca, primary, Di Nardo, Federica, additional, Caiazzo, Giuseppina, additional, Siciliano, Mattia, additional, D’Alvano, Giulia, additional, Ferrantino, Teresa, additional, Passaniti, Carla, additional, Ricciardi, Dario, additional, Esposito, Sabrina, additional, Lavorgna, Luigi, additional, Russo, Antonio, additional, Bonavita, Simona, additional, Cirillo, Mario, additional, Santangelo, Gabriella, additional, Esposito, Fabrizio, additional, and Tedeschi, Gioacchino, additional

Published
2020
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175. Singular cases of Alzheimer’s disease disclose new and old genetic “acquaintances”

Author

Coppola, Cinzia, primary, Saracino, Dario, additional, Oliva, Mariano, additional, Cipriano, Lorenzo, additional, Puoti, Gianfranco, additional, Pappatà, Sabina, additional, Di Fede, Giuseppe, additional, Catania, Marcella, additional, Ricci, Martina, additional, Cimini, Sara, additional, Giaccone, Giorgio, additional, Bonavita, Simona, additional, and Rossi, Giacomina, additional

Published
2020
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176. In Amyotrophic Lateral Sclerosis Blood Cytokines Are Altered, but Do Not Correlate with Changes in Brain Topology

Author

Polverino, Arianna, primary, Rucco, Rosaria, additional, Stillitano, Ilaria, additional, Bonavita, Simona, additional, Grimaldi, Manuela, additional, Minino, Roberta, additional, Pesoli, Matteo, additional, Trojsi, Francesca, additional, D'Ursi, Anna Maria, additional, Sorrentino, Giuseppe, additional, and Sorrentino, Pierpaolo, additional

Published
2020
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177. Resting state functional MRI brain signatures of fast disease progression in amyotrophic lateral sclerosis: a retrospective study

Author

Trojsi, Francesca, primary, Di Nardo, Federica, additional, Siciliano, Mattia, additional, Caiazzo, Giuseppina, additional, Passaniti, Carla, additional, D’Alvano, Giulia, additional, Ricciardi, Dario, additional, Russo, Antonio, additional, Bisecco, Alvino, additional, Lavorgna, Luigi, additional, Bonavita, Simona, additional, Cirillo, Mario, additional, Esposito, Fabrizio, additional, and Tedeschi, Gioacchino, additional

Published
2020
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179. Nabiximols discontinuation rate in a large population of patients with multiple sclerosis: a 18-month multicentre study

Author

Chisari, Clara Grazia, primary, Solaro, Claudio, additional, Annunziata, Pasquale, additional, Bergamaschi, Roberto, additional, Bianco, Assunta, additional, Bonavita, Simona, additional, Brescia Morra, Vincenzo, additional, Bruno Bossio, Roberto, additional, Capello, Elisabetta, additional, Castelli, Letizia, additional, Cavalla, Paola, additional, Costantino, Gianfranco, additional, Centonze, Diego, additional, Cottone, Salvatore, additional, Danni, Maura Chiara, additional, Esposito, Federica, additional, Gajofatto, Alberto, additional, Gasperini, Claudio, additional, Guareschi, Angelica, additional, Lanzillo, Roberta, additional, Lus, Giacomo, additional, Maniscalco, Giorgia Teresa, additional, Matta, Manuela, additional, Paolicelli, Damiano, additional, Petrucci, Loredana, additional, Pontecorvo, Simona, additional, Righini, Isabella, additional, Rovaris, Marco, additional, Sessa, Edoardo, additional, Spinicci, Gabriella, additional, Spitaleri, Daniele, additional, Valentino, Paola, additional, Zaffaroni, Mauro, additional, Zappia, Mario, additional, and Patti, Francesco, additional

Published
2020
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181. First therapy choice in newly diagnosed Multiple Sclerosis patients: A multicenter Italian study

Author

Maniscalco, Giorgia T., primary, Saccà, Francesco, additional, Lanzillo, Roberta, additional, Annovazzi, Pietro, additional, Baroncini, Damiano, additional, Binello, Eleonora, additional, Repice, Annamaria, additional, Perini, Paola, additional, Clerico, Marinella, additional, Mataluni, Giorgia, additional, Bonavita, Simona, additional, La Gioia, Sara, additional, Gutierrez, Lorena Pareja, additional, Laroni, Alice, additional, Frau, Jessica, additional, Cocco, Eleonora, additional, Torri Clerici, Valentina, additional, Zarbo, Ignazio Roberto, additional, Sartori, Arianna, additional, Signoriello, Elisabetta, additional, Rasia, Sarah, additional, Cordioli, Cinzia, additional, Stromillo, Maria Laura, additional, Cerqua, Raffaella, additional, Pontecorvo, Simona, additional, Di Sapio, Alessia, additional, Grasso, Roberta, additional, Barone, Stefania, additional, Lavorgna, Luigi, additional, Barrilà, Caterina, additional, Landi, Doriana, additional, Russo, Cinzia Valeria, additional, Frigeni, Barbara, additional, Ippolito, Domenico, additional, Turano, Gabriella, additional, Carmisciano, Luca, additional, Sormani, Maria Pia, additional, and Signori, Alessio, additional

Published
2020
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182. The Use of Social Media and Digital Devices Among Italian Neurologists

Author

Lavorgna, Luigi, primary, Brigo, Francesco, additional, Abbadessa, Gianmarco, additional, Bucello, Sebastiano, additional, Clerico, Marinella, additional, Cocco, Eleonora, additional, Iodice, Rosa, additional, Lanzillo, Roberta, additional, Leocani, Letizia, additional, Lerario, Alberto, additional, Moccia, Marcello, additional, Padovani, Alessandro, additional, Prosperini, Luca, additional, Repice, Anna, additional, Stromillo, Maria, additional, Trojsi, Francesca, additional, Mancardi, Gianluigi, additional, Tedeschi, Gioacchino, additional, and Bonavita, Simona, additional

Published
2020
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187. Disability assessment in the Google Maps era: a feasibility study to explore a new clinical opportunity (2381)

Author

Abbadessa, Gianmarco, primary, Lavorgna, Luigi, additional, Iaffaldano, Pietro, additional, Lanzillo, Roberta, additional, Esposito, Sabrina, additional, Ippolito, Domenico, additional, Sparaco, Maddalena, additional, Cepparulo, Simone, additional, Lus, Giacomo, additional, Viterbo, Rosa, additional, Clerico, Marinella, additional, Ragonese, Paolo, additional, Borriello, Giovanna, additional, Signoriello, Elisabetta, additional, Trojano, Maria, additional, Tedeschi, Gioacchino, additional, and Bonavita, Simona, additional

Published
2020
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188. Resting-State Functional Correlates of Social Cognition in Multiple Sclerosis: An Explorative Study

Author

Bisecco, Alvino, primary, Altieri, Manuela, additional, Santangelo, Gabriella, additional, Di Nardo, Federica, additional, Docimo, Renato, additional, Caiazzo, Giuseppina, additional, Capuano, Rocco, additional, Pappacena, Simona, additional, d’Ambrosio, Alessandro, additional, Bonavita, Simona, additional, Trojsi, Francesca, additional, Cirillo, Mario, additional, Esposito, Fabrizio, additional, Tedeschi, Gioacchino, additional, and Gallo, Antonio, additional

Published
2020
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189. Extending the Interval of Natalizumab Dosing: Is Efficacy Preserved?

Author

Clerico, Marinella, primary, De Mercanti, Stefania Federica, additional, Signori, Alessio, additional, Iudicello, Marco, additional, Cordioli, Cinzia, additional, Signoriello, Elisabetta, additional, Lus, Giacomo, additional, Bonavita, Simona, additional, Lavorgna, Luigi, additional, Maniscalco, Giorgia Teresa, additional, Curti, Erica, additional, Lorefice, Lorena, additional, Cocco, Eleonora, additional, Nociti, Viviana, additional, Mirabella, Massimiliano, additional, Baroncini, Damiano, additional, Mataluni, Giorgia, additional, Landi, Doriana, additional, Petruzzo, Martina, additional, Lanzillo, Roberta, additional, Gandoglia, Ilaria, additional, Laroni, Alice, additional, Frangiamore, Rita, additional, Sartori, Arianna, additional, Cavalla, Paola, additional, Costantini, Gianfranco, additional, Sormani, Maria Pia, additional, and Capra, Ruggero, additional

Published
2020
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190. Sex effects across the lifespan in women with multiple sclerosis

Author

Krysko, Kristen M., primary, Graves, Jennifer S., additional, Dobson, Ruth, additional, Altintas, Ayse, additional, Amato, Maria Pia, additional, Bernard, Jacqueline, additional, Bonavita, Simona, additional, Bove, Riley, additional, Cavalla, Paola, additional, Clerico, Marinella, additional, Corona, Teresa, additional, Doshi, Anisha, additional, Fragoso, Yara, additional, Jacobs, Dina, additional, Jokubaitis, Vilija, additional, Landi, Doriana, additional, Llamosa, Gloria, additional, Longbrake, Erin E., additional, Maillart, Elisabeth, additional, Marta, Monica, additional, Midaglia, Luciana, additional, Shah, Suma, additional, Tintore, Mar, additional, van der Walt, Anneke, additional, Voskuhl, Rhonda, additional, Wang, Yujie, additional, Zabad, Rana K., additional, Zeydan, Burcu, additional, Houtchens, Maria, additional, and Hellwig, Kerstin, additional

Published
2020
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191. Regional changes in thalamic shape and volume are related to cognitive performance in multiple sclerosis

Author

Bisecco, Alvino, primary, Capuano, Rocco, additional, Caiazzo, Giuseppina, additional, d’Ambrosio, Alessandro, additional, Docimo, Renato, additional, Cirillo, Mario, additional, Russo, Antonio, additional, Altieri, Manuela, additional, Bonavita, Simona, additional, Rocca, Maria A, additional, Filippi, Massimo, additional, Tedeschi, Gioacchino, additional, and Gallo, Antonio, additional

Published
2019
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192. Efficacy of different rituximab therapeutic strategies in patients with neuromyelitis optica spectrum disorders

Author

Novi, Giovanni, primary, Bovis, Francesca, additional, Capobianco, Marco, additional, Frau, Jessica, additional, Mataluni, Giorgia, additional, Curti, Erica, additional, Zuliani, Luigi, additional, Cavalla, Paola, additional, Brambilla, Laura, additional, Annovazzi, Pietro, additional, Repice, Anna Maria, additional, Lanzillo, Roberta, additional, Esposito, Sabrina, additional, Benedetti, Luana, additional, Maietta, Ilaria, additional, Sica, Francesco, additional, Buttari, Fabio, additional, Malucchi, Simona, additional, Fenu, Giuseppe, additional, Landi, Doriana, additional, Bosa, Chiara, additional, Realmuto, Sabrina, additional, Malentacchi, Maria, additional, Granella, Franco, additional, Signori, Alessio, additional, Bonavita, Simona, additional, Uccelli, Antonio, additional, and Sormani, Maria Pia, additional

Published
2019
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193. Predictors of Catching COVID-19 Infection during Pandemic Stage in Patients with Multiple Sclerosis (MS)

Author

Ghajarzadeh, Mahsa, Mirmosayyeb, Omid, Molazadeh, Negar, Sahraian, Mohammad Ali, Bonavita, Simona, Shaygannejad, Vahid, Ghajarzadeh, Mahsa, Mirmosayyeb, Omid, Molazadeh, Negar, Sahraian, Mohammad Ali, Bonavita, Simona, and Shaygannejad, Vahid

Subjects
multiple sclerosi, Public Health, Environmental and Occupational Health, COVID-19, predictor, Iran
Abstract

Patients with multiple sclerosis (MS) are considered at higher risk of COVID-19 infection due to treatment with immune modulators and immune-suppressive agents. The exact risk factors are not clear. So, we aimed to conduct a study to determine the predictors of catching COVID-19 infection during the pandemic stage in patients with multiple sclerosis (MS).We conducted a multicenter screening study and developed an online questionnaire to collect patients' self-reported demographic features along with MS-related and COVID-19-related information. The online questionnaire link was released by the Iran Multiple Sclerosis Society (IMSS) social media channel, accessible for 4160 MS patients totally and also was sent by WhatsApp for nonmember cases.Totally, 1448 MS patients participated in our study. Twenty-five (1.7%) patients were diagnosed with COVID-19, from which 4 were hospitalized, 4 were treated with medical therapy, and 17 patients had home-quarantine. The patients with COVID-19 diagnosis were more frequently treated with rituximab (28% vs 24%,Patients with MS who have cardiovascular disease should be more monitored for COVID-19 infection as they are at higher risk of infection.

Published
2018

195. Switch from sequestering to anti-CD20 depleting treatment: disease activity outcomes during wash-out and in the first 6 months of ocrelizumab therapy.

Author

Signoriello, Elisabetta, Lus, Giacomo, Bonavita, Simona, Lanzillo, Roberta, Saccà, Francesco, Landi, Doriana, Frau, Jessica, Baroncini, Damiano, Zaffaroni, Mauro, Maniscalco, Giorgia Teresa, Curti, Erica, Sartori, Arianna, Cepparulo, Simone, Marfia, Girolama Alessandra, Nicoletti, Carolina Gabri, Carotenuto, Antonio, Nociti, Viviana, Caleri, Francesca, Sormani, Maria Pia, and Signori, Alessio

Subjects
THERAPEUTICS, MAGNETIC resonance imaging, LYMPHOCYTE count, DISEASE relapse, MULTIPLE sclerosis
Abstract

Objectives: Switching between treatments is an opportunity for patients with multiple sclerosis (MS) to ameliorate disease control or safety. The aim of this study was to investigate the impact of switching from fingolimod (FTY) or natalizumab (NTZ) to ocrelizumab (OCR) on disease activity. Methods: We retrospectively enrolled 165 patients treated with OCR from 11 MS centres. We assessed the association of demographic and clinical characteristics on relapse rate (RR) and activity on magnetic resonance imaging (MRI) during wash-out and after 6 months of treatment with OCR through univariable and multivariable negative binomial regression models. Results: We registered a total of 35 relapses during the wash-out period. Previous treatment with FTY, relapses in the previous year, and relapsing-remitting course were associated with higher RR. In the first 6 months of OCR, 12 patients had clinical or MRI disease activity. Higher Expanded Disability Status Scale (EDSS) and higher lymphocyte count at OCR start were associated with a reduced probability of relapse. Discussion and Conclusion: This study confirms that withdrawal from sequestering agents as FTY increases the risk of relapses in the wash-out period. Nevertheless, starting OCR before achieving complete immune reconstitution could limit its effectiveness in the first 6 months probably because trapped lymphocytes escape the CD20-mediated depletion. [ABSTRACT FROM AUTHOR]

Published
2022
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196. A real‐world study of alemtuzumab in a cohort of Italian patients.

Author

Russo, Cinzia Valeria, Saccà, Francesco, Frau, Jessica, Annovazzi, Pietro, Signoriello, Elisabetta, Bonavita, Simona, Grasso, Roberta, Clerico, Marinella, Cordioli, Cinzia, Laroni, Alice, Capobianco, Marco, Torri Clerici, Valentina, Sartori, Arianna, Cavalla, Paola, Maniscalco, Giorgia Teresa, La Gioia, Sara, Caleri, Francesca, Giugno, Alessia, Iodice, Rosa, and Carotenuto, Antonio

Subjects
MAGNETIC resonance imaging, GLATIRAMER acetate, NATALIZUMAB, ALEMTUZUMAB, PROGRESSION-free survival
Abstract

Background and purpose: Real‐world data on alemtuzumab are limited and do not provide evidence of its effectiveness after various disease‐modifying therapies (DMTs). Our aim was to provide real‐world data on the impact of clinical variables and previous DMTs on clinical response to alemtuzumab. Methods: Sixteen Italian multiple sclerosis centers retrospectively included patients who started alemtuzumab from January 2015 to December 2018, and recorded demographics, previous therapies, washout duration, relapses, Expanded Disability Status Scale (EDSS) score, and magnetic resonance imaging data. Negative binomial regression models were used to assess the effect of factors on annualized relapse (ARR) after alemtuzumab initiation. Results: We studied 322 patients (mean age 36.8 years, median EDSS score 3, median follow‐up 1.94 years). Previous treatments were: fingolimod (106), natalizumab (80), first‐line oral agents (56), first‐line injectables (interferon/glatiramer acetate; 30), and other drugs (15). Thirty‐five patients were treatment‐naïve. The pre‐alemtuzumab ARR was 0.99 and decreased to 0.13 during alemtuzumab treatment (p < 0.001). The number of previous‐year relapses was associated with alemtuzumab ARR (adjusted risk ratio [RR] 1.38, p = 0.009). Progression‐free survival was 94.5% after 1 year, and 89.2% after 2 years of alemtuzumab treatment. EDSS score improvement occurred in 13.5% after 1 year, and 20.6% after 2 years. Re‐baselining patients after 6 months of alemtuzumab treatment, led to no evidence of disease activity status in 71.6% after 1 year and 58.9% after 2 years. Conclusions: Alemtuzumab decreases ARR independent of previous therapy, including patients with disease activity during natalizumab treatment. Overall, 90% of patients showed no disease progression, and 20% an improvement after 2 years of alemtuzumab. [ABSTRACT FROM AUTHOR]

Published
2022
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198. Myasthenia gravis and telemedicine: a lesson from COVID-19 pandemic.

Author

Ricciardi, Dario, Casagrande, Silvia, Iodice, Francesco, Orlando, Bianca, Trojsi, Francesca, Cirillo, Giovanni, Clerico, Marinella, Bozzali, Marco, Leocani, Letizia, Abbadessa, Gianmarco, Miele, Giuseppina, Tedeschi, Gioacchino, Bonavita, Simona, and Lavorgna, Luigi

Subjects
COVID-19 pandemic, MYASTHENIA gravis, CONTINUUM of care, EARLY diagnosis, NEUROLOGICAL disorders, TELEMEDICINE
Abstract

COVID-19 pandemic has induced an urgent reorganization of the healthcare system to ensure continuity of care for patients affected by chronic neurological diseases including myasthenia gravis (MG). Due to the fluctuating nature of the disease, early detection of disease worsening, adverse events, and possibly life-threatening complications is mandatory. This work analyzes the main unresolved issues in the management of the myasthenic patient, the possibilities offered so far by digital technologies, and proposes an online evaluation protocol based on 4 simple tests to improve MG management. Telemedicine and Digital Technology might help neurologists in the clinical decision-making process of MG management, avoiding unnecessary in presence consultations and allowing a rational use of the time and space reduced by the pandemic. [ABSTRACT FROM AUTHOR]

Published
2021
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199. Between-sex variability of resting state functional brain networks in amyotrophic lateral sclerosis (ALS).

Author

Trojsi, Francesca, Di Nardo, Federica, Caiazzo, Giuseppina, Siciliano, Mattia, D'Alvano, Giulia, Passaniti, Carla, Russo, Antonio, Bonavita, Simona, Cirillo, Mario, Esposito, Fabrizio, and Tedeschi, Gioacchino

Subjects
LARGE-scale brain networks, AMYOTROPHIC lateral sclerosis, DEFAULT mode network, PREFRONTAL cortex, SALIENCE network
Abstract

The organization of brain functional connectivity (FC) has been shown to differ between sexes. Amyotrophic lateral sclerosis (ALS) is characterized by sexual dimorphism, showing sex-specific trends in site of onset, phenotypes, and prognosis. Here, we explored resting state (RS) FC differences within major large-scale functional networks between women and men in a sample of ALS patients, in comparison to healthy controls (HCs). A group-level independent component analysis (ICA) was performed on RS-fMRI time-series enabling spatial and spectral analyses of large-scale RS FC networks in 45 patients with ALS (20 F; 25 M) and 31 HCs (15 F; 16 M) with a focus on sex-related differences. A whole-brain voxel-based morphometry (VBM) was also performed to highlight atrophy differences. Between-sex comparisons showed: decreased FC in the right middle frontal gyrus and in the precuneus within the default mode network (DMN), in affected men compared to affected women; decreased FC in the right post-central gyrus (sensorimotor network), in the right inferior parietal gyrus (right fronto-parietal network) and increased FC in the anterior cingulate cortex and right insula (salience network), in both affected and non-affected men compared to women. When comparing affected men to affected women, VBM analysis revealed atrophy in men in the right lateral occipital cortex. Our results suggest that in ALS sex-related trends of brain functional and structural changes are more heavily represented in DMN and in the occipital cortex, suggesting that sex is an additional dimension of functional and structural heterogeneity in ALS. [ABSTRACT FROM AUTHOR]

Published
2021
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