Search

Your search keyword '"Blot, William J."' showing total 2,270 results
Start Over Author "Blot, William J."
2,270 results on '"Blot, William J."'

153. Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score

Author

Minh-Phuong Huynh-Le, Karunamuni, Roshan, Fan, Chun Chieh, Asona, Lui, Thompson, Wesley K., Martinez, Maria Elena, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth R., Lophatananon, Artitaya, Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, Groenberg, Henrik, Neal, David E., Nordestgaard, Borge G., Tangen, Catherine M., MacInnis, Robert J., Wolk, Alicja, Albanes, Demetrius, Haiman, Christopher A., Travis, Ruth C., Blot, William J., Stanford, Janet L., Mucci, Lorelei A., West, Catharine M. L., Nielsen, Sune F., Kibel, Adam S., Cussenot, Olivier, Berndt, Sonja, Koutros, Stella, Sorensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Menegaux, Florence, Park, Jong Y., Ingles, Sue A., Maier, Christiane, Hamilton, Robert J., Rosenstein, Barry S., Lu, Yong-Jie, Watya, Stephen, Vega, Ana, Kogevinas, Manolis, Wiklund, Fredrik, Penney, Kathryn L., Huff, Chad D., Teixeira, Manuel R., Multigner, Luc, Leach, Robin J., Minh-Phuong Huynh-Le, Karunamuni, Roshan, Fan, Chun Chieh, Asona, Lui, Thompson, Wesley K., Martinez, Maria Elena, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth R., Lophatananon, Artitaya, Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, Groenberg, Henrik, Neal, David E., Nordestgaard, Borge G., Tangen, Catherine M., MacInnis, Robert J., Wolk, Alicja, Albanes, Demetrius, Haiman, Christopher A., Travis, Ruth C., Blot, William J., Stanford, Janet L., Mucci, Lorelei A., West, Catharine M. L., Nielsen, Sune F., Kibel, Adam S., Cussenot, Olivier, Berndt, Sonja, Koutros, Stella, Sorensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Menegaux, Florence, Park, Jong Y., Ingles, Sue A., Maier, Christiane, Hamilton, Robert J., Rosenstein, Barry S., Lu, Yong-Jie, Watya, Stephen, Vega, Ana, Kogevinas, Manolis, Wiklund, Fredrik, Penney, Kathryn L., Huff, Chad D., Teixeira, Manuel R., Multigner, Luc, and Leach, Robin J.

Abstract

Background Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs in a prostate cancer polygenic hazard score (PHS) would improve associations with clinically significant prostate cancer in multi-ancestry datasets. Methods In total, 299 SNPs previously associated with prostate cancer were evaluated for inclusion in a new PHS, using a LASSO-regularized Cox proportional hazards model in a training dataset of 72,181 men from the PRACTICAL Consortium. The PHS model was evaluated in four testing datasets: African ancestry, Asian ancestry, and two of European Ancestry-the Cohort of Swedish Men (COSM) and the ProtecT study. Hazard ratios (HRs) were estimated to compare men with high versus low PHS for association with clinically significant, with any, and with fatal prostate cancer. The impact of genetic risk stratification on the positive predictive value (PPV) of PSA testing for clinically significant prostate cancer was also measured. Results The final model (PHS290) had 290 SNPs with non-zero coefficients. Comparing, for example, the highest and lowest quintiles of PHS290, the hazard ratios (HRs) for clinically significant prostate cancer were 13.73 [95% CI: 12.43-15.16] in ProtecT, 7.07 [6.58-7.60] in African ancestry, 10.31 [9.58-11.11] in Asian ancestry, and 11.18 [10.34-12.09] in COSM. Similar results were seen for association with any and fatal prostate cancer. Without PHS stratification, the PPV of PSA testing for clinically significant prostate cancer in ProtecT was 0.12 (0.11-0.14). For the top 20% and top 5% of PHS290, the PPV of PSA testing was 0.19 (0.15-0.22) and 0.26 (0.19-0.33), respectively. Conclusions We demonstrate better genetic risk stratification for clinically significant prostate cancer than prior versions of PHS in multi-ancestry da

Published
2022

157. Association of Race and Income with Incident Diagnosis of Alzheimer's Disease and Related Dementias among Black and White Older Adults.

Author

Keohane, Laura M., Nikpay, Sayeh, Braun, Kyle, Cheng, Audrey, Stevenson, David, Buntin, Melinda B., Yu, Danxia, Blot, William J., and Lipworth, Loren

Abstract

To investigate how differences in income and education levels may contribute to disparities in incidence of Alzheimer's disease and related dementia (ADRD), we compared ADRD incidence in traditional Medicare claims for 11,132 Black and 7703 White participants aged 65 and over from a predominantly low-income cohort. We examined whether the relationship between ADRD incidence and race varied by income or education. Based on 2015 incident ADRD diagnoses, Black and White participants had unadjusted incidence rates of 26.5 and 23.2 cases per 1000 person-years, respectively (rate ratio 1.14, 95% CI 1.05–1.25). In multivariable Cox proportional hazard models, the relationship between race and incident ADRD diagnosis did not vary by education level (p-interaction = 0.748) but was modified by income level (p-interaction = 0.007), with higher ADRD incidence among Black participants observed only among higher income groups. These results highlight the importance of understanding how race and economic factors influence ADRD incidence and diagnosis rates. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

158. The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium

Author

Davies, Neil M., Gaunt, Tom R., Lewis, Sarah J., Holly, Jeff, Donovan, Jenny L., Hamdy, Freddie C., Kemp, John P., Eeles, Rosalind, Easton, Doug, Kote-Jarai, Zsofia, Al Olama, Ali Amin, Benlloch, Sara, Muir, Kenneth, Giles, Graham G., Wiklund, Fredrik, Gronberg, Henrik, Haiman, Christopher A., Schleutker, Johanna, Nordestgaard, Børge G., Travis, Ruth C., Neal, David, Pashayan, Nora, Khaw, Kay-Tee, Stanford, Janet L., Blot, William J., Thibodeau, Stephen, Maier, Christiane, Kibel, Adam S., Cybulski, Cezary, Cannon-Albright, Lisa, Brenner, Hermann, Park, Jong, Kaneva, Radka, Batra, Jyotsna, Teixeira, Manuel R., Pandha, Hardev, Lathrop, Mark, Smith, George Davey, Martin, Richard M., and PRACTICAL consortium

Published
2015
Full Text
View/download PDF

159. A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry

Author

Darst, Burcu F., Hughley, Raymond, Pfennig, Aaron, Hazra, Ujani, Fan, Caoqi, Wan, Peggy, Sheng, Xin, Xia, Lucy, Andrews, Caroline, Chen, Fei, Berndt, Sonja I., Kote-Jarai, Zsofia, Govindasami, Koveela, Bensen, Jeannette T., Ingles, Sue A., Rybicki, Benjamin A., Nemesure, Barbara, John, Esther M., Fowke, Jay H., Huff, Chad D., Strom, Sara S., Isaacs, William B., Park, Jong Y., Zheng, Wei, Ostrander, Elaine A., Walsh, Patrick C., Carpten, John, Sellers, Thomas A., Yamoah, Kosj, Murphy, Adam B., Sanderson, Maureen, Crawford, Dana C., Gapstur, Susan M., Bush, William S., Aldrich, Melinda C., Cussenot, Olivier, Petrovics, Gyorgy, Cullen, Jennifer, Neslund-Dudas, Christine, Kittles, Rick A., Xu, Jianfeng, Stern, Mariana C., Chokkalingam, Anand P., Multigner, Luc, Parent, Marie-Elise, Menegaux, Florence, Cancel-Tassin, Geraldine, Kibel, Adam S., Klein, Eric A., Goodman, Phyllis J., Stanford, Janet L., Drake, Bettina F., Hu, Jennifer J., Clark, Peter E., Blanchet, Pascal, Casey, Graham, Hennis, Anselm J.M., Lubwama, Alexander, Thompson, Ian M., Jr, Leach, Robin J., Gundell, Susan M., Pooler, Loreall, Mohler, James L., Fontham, Elizabeth T.H., Smith, Gary J., Taylor, Jack A., Brureau, Laurent, Blot, William J., Biritwum, Richard, Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Tettey, Yao, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Jalloh, Mohamed, Magueye Gueye, Serigne, Niang, Lamine, Ogunbiyi, Olufemi, Oladimeji Idowu, Michael, Popoola, Olufemi, Adebiyi, Akindele O., Aisuodionoe-Shadrach, Oseremen I., Nwegbu, Maxwell, Adusei, Ben, Mante, Sunny, Darkwa-Abrahams, Afua, Yeboah, Edward D., Mensah, James E., Anthony Adjei, Andrew, Diop, Halimatou, Cook, Michael B., Chanock, Stephen J., Watya, Stephen, Eeles, Rosalind A., Chiang, Charleston W.K., Lachance, Joseph, Rebbeck, Timothy R., Conti, David V., and Haiman, Christopher A.

Published
2022
Full Text
View/download PDF

166. Supplemental Material - Association of Race and Income with Incident Diagnosis of Alzheimer’s Disease and Related Dementias among Black and White Older Adults

Author

Keohane, Laura M., Nikpay, Sayeh, Braun, Kyle, Cheng, Audrey, Stevenson, David, Buntin, Melinda B., Yu, Danxia, Blot, William J., and Lipworth, Loren

Subjects
FOS: Clinical medicine, 111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology
Abstract

Supplementary Material for Association of Race and Income with Incident Diagnosis of Alzheimer’s Disease and Related Dementias among Black and White Older Adults by Laura M. Keohane, Sayeh Nikpay, Kyle Braun, Audrey Cheng, David Stevenson, Melinda B. Buntin, Danxia Yu, William J. Blot, and Loren Lipworth in Journal of Applied Gerontology.

Published
2022
Full Text
View/download PDF

170. A functionally significant SNP in TP53 and breast cancer risk in African-American women

Author

Murphy, Maureen E., Liu, Song, Yao, Song, Huo, Dezheng, Liu, Qin, Dolfi, Sonia C., Hirshfield, Kim M., Hong, Chi-Chen, Hu, Qiang, Olshan, Andrew F., Ogundiran, Temidayo O., Adebamowo, Clement, Domchek, Susan M., Nathanson, Katherine L., Nemesure, Barbara, Ambs, Stefan, Blot, William J., Feng, Ye, John, Esther M., Bernstein, Leslie, Zheng, Wei, Hu, Jennifer J., Ziegler, Regina G., Nyante, Sarah, Ingles, Sue A., Press, Michael F., Deming, Sandra L., Rodriguez-Gil, Jorge L., Haiman, Christopher A., Olopade, Olufunmilayo I., Lunetta, Kathryn L., Palmer, Julie R., and Ambrosone, Christine B.

Published
2017
Full Text
View/download PDF

183. Response

Author

Fryzek, Jon P., Cohen, Sarah, Chadda, Bandana, Marano, Donald, White, Kenneth, McLaughlin, Joseph K., and Blot, William J

Published
2004

185. Prospective study of oral microbiome and gastric cancer risk among Asian, African American and European American populations

Author

Yang, Yaohua, primary, Long, Jirong, additional, Wang, Cong, additional, Blot, William J., additional, Pei, Zhiheng, additional, Shu, Xiang, additional, Wu, Fen, additional, Rothman, Nathaniel, additional, Wu, Jie, additional, Lan, Qing, additional, Cai, Qiuyin, additional, Zheng, Wei, additional, Chen, Yu, additional, and Shu, Xiao‐Ou, additional

Published
2021
Full Text
View/download PDF

189. Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions

Author

Han, Ying, Hazelett, Dennis J., Wiklund, Fredrik, Schumacher, Fredrick R., Stram, Daniel O., Berndt, Sonja I., Wang, Zhaoming, Rand, Kristin A., Hoover, Robert N., Machiela, Mitchell J., Yeager, Merideth, Burdette, Laurie, Chung, Charles C., Hutchinson, Amy, Yu, Kai, Xu, Jianfeng, Travis, Ruth C., Key, Timothy J., Siddiq, Afshan, Canzian, Federico, Takahashi, Atsushi, Kubo, Michiaki, Stanford, Janet L., Kolb, Suzanne, Gapstur, Susan M., Diver, W. Ryan, Stevens, Victoria L., Strom, Sara S., Pettaway, Curtis A., Al Olama, Ali Amin, Kote-Jarai, Zsofia, Eeles, Rosalind A., Yeboah, Edward D., Tettey, Yao, Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Chokkalingam, Anand P., Isaacs, William B., Chen, Constance, Lindstrom, Sara, Le Marchand, Loic, Giovannucci, Edward L., Pomerantz, Mark, Long, Henry, Li, Fugen, Ma, Jing, Stampfer, Meir, John, Esther M., Ingles, Sue A., Kittles, Rick A., Murphy, Adam B., Blot, William J., Signorello, Lisa B., Zheng, Wei, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Nemesure, Barbara, Carpten, John, Leske, M. Cristina, Wu, Suh-Yuh, Hennis, Anselm J. M., Rybicki, Benjamin A., Neslund-Dudas, Christine, Hsing, Ann W., Chu, Lisa, Goodman, Phyllis J., Klein, Eric A., Zheng, S. Lilly, Witte, John S., Casey, Graham, Riboli, Elio, Li, Qiyuan, Freedman, Matthew L., Hunter, David J., Gronberg, Henrik, Cook, Michael B., Nakagawa, Hidewaki, Kraft, Peter, Chanock, Stephen J., Easton, Douglas F., Henderson, Brian E., Coetzee, Gerhard A., Conti, David V., and Haiman, Christopher A.

Published
2015
Full Text
View/download PDF

193. Generalizability of established prostate cancer risk variants in men of African ancestry

Author

Han, Ying, Signorello, Lisa B., Strom, Sara S., Kittles, Rick A., Rybicki, Benjamin A., Stanford, Janet L., Goodman, Phyllis J., Berndt, Sonja I., Carpten, John, Casey, Graham, Chu, Lisa, Conti, David V., Rand, Kristin A., Diver, Ryan W., Hennis, Anselm J.M., John, Esther M., Kibel, Adam S., Klein, Eric A., Kolb, Suzanne, Le Marchand, Loic, Leske, Cristina M., Murphy, Adam B., Neslund-Dudas, Christine, Park, Jong Y., Pettaway, Curtis, Rebbeck, Timothy R., Gapstur, Susan M., Zheng, Lilly S., Wu, Suh-Yuh, Witte, John S., Xu, Jianfeng, Isaacs, William, Ingles, Sue A., Hsing, Ann, Easton, Douglas F., Eeles, Rosalind A., Schumacher, Fredrick R., Chanock, Stephen, Nemesure, Barbara, Blot, William J., Stram, Daniel O., Henderson, Brian E., and Haiman, Christopher A.

Published
2015
Full Text
View/download PDF

196. Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry

Author

Graff, Mariaelisa, Justice, Anne E, Young, Kristin L, Marouli, Eirini, Zhang, Xinruo, Fine, Rebecca S, Lim, Elise, Buchanan, Victoria, Rand, Kristin, Feitosa, Mary F, Wojczynski, Mary K, Yanek, Lisa R, Shao, Yaming, Rohde, Rebecca, Adeyemo, Adebowale A, Aldrich, Melinda C, Allison, Matthew A, Ambrosone, Christine B, Ambs, Stefan, Amos, Christopher, Arnett, Donna K, Atwood, Larry, Bandera, Elisa V, Bartz, Traci, Becker, Diane M, Berndt, Sonja I, Bernstein, Leslie, Bielak, Lawrence F, Blot, William J, Bottinger, Erwin P, Bowden, Donald W, Bradfield, Jonathan P, Brody, Jennifer A, Broeckel, Ulrich, Burke, Gregory, Cade, Brian E, Cai, Qiuyin, Caporaso, Neil, Carlson, Chris, Carpten, John, Casey, Graham, Chanock, Stephen J, Chen, Guanjie, Chen, Minhui, Chen, Yii-Der I, Chen, Wei-Min, Chesi, Alessandra, Chiang, Charleston WK, Chu, Lisa, Coetzee, Gerry A, Conti, David V, Cooper, Richard S, Cushman, Mary, Demerath, Ellen, Deming, Sandra L, Dimitrov, Latchezar, Ding, Jingzhong, Diver, W Ryan, Duan, Qing, Evans, Michele K, Falusi, Adeyinka G, Faul, Jessica D, Fornage, Myriam, Fox, Caroline, Freedman, Barry I, Garcia, Melissa, Gillanders, Elizabeth M, Goodman, Phyllis, Gottesman, Omri, Grant, Struan FA, Guo, Xiuqing, Hakonarson, Hakon, Haritunians, Talin, Harris, Tamara B, Harris, Curtis C, Henderson, Brian E, Hennis, Anselm, Hernandez, Dena G, Hirschhorn, Joel N, McNeill, Lorna Haughton, Howard, Timothy D, Howard, Barbara, Hsing, Ann W, Hsu, Yu-Han H, Hu, Jennifer J, Huff, Chad D, Huo, Dezheng, Ingles, Sue A, Irvin, Marguerite R, John, Esther M, Johnson, Karen C, Jordan, Joanne M, Kabagambe, Edmond K, Kang, Sun J, Kardia, Sharon L, Keating, Brendan J, Kittles, Rick A, Klein, Eric A, Kolb, Suzanne, and Kolonel, Laurence N

Subjects
Male, Genetics & Heredity, Human Genome, Black People, Single Nucleotide, Biological Sciences, Medical and Health Sciences, Body Height, Europe, Black or African American, genome-wide, fine-mapping, African ancestry, Africa, Genetics, Humans, Female, Polymorphism, Genome-Wide Association Study, height
Abstract

Although many loci have been associated with height in European ancestry populations, very few have been identified in African ancestry individuals. Furthermore, many of the known loci have yet to be generalized to and fine-mapped within a large-scale African ancestry sample. We performed sex-combined and sex-stratified meta-analyses in up to 52,764 individuals with height and genome-wide genotyping data from the African Ancestry Anthropometry Genetics Consortium (AAAGC). We additionally combined our African ancestry meta-analysis results with published European genome-wide association study (GWAS) data. In the African ancestry analyses, we identified three novel loci (SLC4A3, NCOA2, ECD/FAM149B1) in sex-combined results and two loci (CRB1, KLF6) in women only. In the African plus European sex-combined GWAS, we identified an additional three novel loci (RCCD1, G6PC3, CEP95) which were equally driven by AAAGC and European results. Among 39 genome-wide significant signals at known loci, conditioning index SNPs from European studies identified 20 secondary signals. Two of the 20 new secondary signals and none of the 8 novel loci had minor allele frequencies (MAF) < 5%. Of 802 known European height signals, 643 displayed directionally consistent associations with height, of which 205 were nominally significant (p < 0.05) in the African ancestry sex-combined sample. Furthermore, 148 of 241 loci contained ≤20 variants in the credible sets that jointly account for 99% of the posterior probability of driving the associations. In summary, trans-ethnic meta-analyses revealed novel signals and further improved fine-mapping of putative causal variants in loci shared between African and European ancestry populations.

Published
2021

197. Oral and Pharyngeal Cancer and Occupation: A Case-Control Study

Author

Huebner, Wendy W., Schoenberg, Janet B., Kelsey, Jennifer L., Wilcox, Homer B., McLaughlin, Joseph K., Greenberg, Raymond S., Preston-Martin, Susan, Austin, Donald F., Stemhagen, Annette, Blot, William J., Winn, Deborah M., and Fraumeni,, Joseph F.

Published
1992

Catalog

Books, media, physical & digital resources
See catalog results