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1,701 results on '"Bishop, G."'

153. Alloactivation of Naïve CD4+CD8−CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction.

Author

Verma, Nirupama D., Robinson, Catherine M., Carter, Nicole, Wilcox, Paul, Tran, Giang T., Wang, Chaunmin, Sharland, Alexandra, Nomura, Masaru, Plain, Karren M., Bishop, G. Alexander, Hodgkinson, Suzanne J., and Hall, Bruce M.

Subjects
SUPPRESSOR cells, CELLS, TRANSPLANTATION of organs, tissues, etc.
Abstract

Therapy with alloantigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells. Naïve tTreg from DA rats cultured with fully allogeneic PVG stimulator cells in the presence of rIL-2 express IFN-gamma receptor (IFNGR) and IL-12 receptor beta2 (IL-12Rβ2) and are more potent alloantigen-specific regulators that we call Ts1 cells. This study examined additional markers that could identify the activated alloantigen-specific Treg as a subpopulation within the CD4+CD25+Foxp3+Treg. After culture of naïve DA CD4+CD8−CD25+T cells with rIL-2 and PVG alloantigen, or rIL-2 without alloantigen, CD8α was expressed on 10–20% and CD8β on <5% of these cells. These cells expressed ifngr and Il12rb2. CD8α+ cells had increased Ifngr that characterizes Ts1 cells as well was Irf4 , a transcription factor induced by TCR activation. Proliferation induced by re-culture with rIL-12 and alloantigen was greater with CD4+CD8α+CD25+Treg consistent with the CD8α+ cells expressing IL-12R. In MLC, the CD8α+ fraction suppressed responses against allogeneic stimulators more than the mixed Ts1 population, whereas the CD4+CD8−CD25+T cells were less potent. In an adoptive transfer assay, rIL-2 and alloantigen activated Treg suppress rejection at a ratio of 1:10 with naïve effector cells, whereas alloantigen and rIL-2 activated tTreg depleted of the CD8α+ cells were much less effective. This study demonstrated that expression of CD8α by rIL-2 and alloantigen activation of CD4+CD8−CD25+Foxp3+T cells was a marker of activated and potent Treg that included alloantigen-specific Treg. [ABSTRACT FROM AUTHOR]

Published
2019
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162. Liver Transplant Tolerance and Its Application to the Clinic: Can We Exploit the High Dose Effect?

Author

Cunningham, Eithne C., Sharland, Alexandra F., and Bishop, G. Alex

Subjects
Article Subject
Abstract

The tolerogenic properties of the liver have long been recognised, especially in regard to transplantation. Spontaneous acceptance of liver grafts occurs in a number of experimental models and also in a proportion of clinical transplant recipients. Liver graft acceptance results from donor antigen-specific tolerance, demonstrated by the extension of tolerance to other grafts of donor origin. A number of factors have been proposed to be involved in liver transplant tolerance induction, including the release of soluble major histocompatibility (MHC) molecules from the liver, its complement of immunosuppressive donor leucocytes, and the ability of hepatocytes to directly interact with and destroy antigen-specific T cells. The large tissue mass of the liver has also been suggested to act as a cytokine sink, with the potential to exhaust the immune response. In this review, we outline the growing body of evidence, from experimental models and clinical transplantation, which supports a role for large tissue mass and high antigen dose in the induction of tolerance. We also discuss a novel gene therapy approach to exploit this dose effect and induce antigen-specific tolerance robust enough to overcome a primed T cell memory response.

Published
2013
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163. Tolerance to rat liver allografts. III. Donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues

Author

Bishop, G. A., Sun, J., Decruz, D. J., Rokahr, K. L., Sedgwick, J. D., Sheil, A. G. R., Gallagher, N. D., and GEOFFREY MCCAUGHAN

Subjects
Immunology, Immunology and Allergy
Abstract

The aim of this work was to investigate the mechanism of spontaneous rat liver allograft tolerance. Liver allografts from a LEW donor into DA recipient (LEW-->DA) or of PVG-->DA were spontaneously tolerated (TOL) across a complete MHC mismatch. In contrast, DA-->LEW or PVG-->LEW liver allografts were rejected in 10 to 15 days (REJ). We examined whether donor cell migration to recipient lymphoid tissues might be associated with TOL. Many donor cells were observed in draining (celiac) lymph nodes (LN) and spleen, reaching a peak on day 1 and then decreasing rapidly thereafter. Irradiation of liver donors, which we have previously shown to delete tolerance, significantly reduced the number of donor leukocytes in recipient lymphoid tissues. While this suggested an association between donor cell migration and tolerance, the number, distribution, and type of donor cells in recipient lymphoid tissues of REJ was similar to those of TOL. Expression of cytokine mRNA in LN and spleen showed an early increase in the expression of IL-2 and IFN-gamma mRNA on day 1 and then a rapid decrease to constitutive levels. Spleen and LN levels of IL-6, IL-10, TNF-alpha, or TGF-beta mRNA showed much less up-regulation than IL-2 or IFN-gamma. Paradoxically, there was greater expression of IL-2 and IFN-gamma mRNA in TOL lymphoid tissues than in REJ, and this superinduction was partially prevented by donor irradiation. Superinduction of IL-2 and IFN-gamma was, therefore, more closely associated with TOL than was donor cell migration. This was confirmed by treatment of TOL recipients with a short course of methylprednisolone, which reduced survival of subsequent donor strain skin grafts. This finding has implications for treatment of human liver transplants and is evidence for a novel pathway of transplant tolerance.

Published
1996

164. Futtermittel

Author

Ayre, C. A., van Slyke, D. D., Calvery, H. O., Vickery, H. B., Leavenworth, C. S., Ferguson, W. S., Bishop, G., Peterson, W. J., Hughes, J. S., Freeman, H. F., Flieg, O., Guanzon, G. A., Sandstrom, W. M., Fraps, G. S., Dickson, A. D., Otterson, H., Link, K. P., Anderson, E., Norris, F. W., Resch, C. E., Kennedy, Nason, H. K., Nottbohm, F. E., Mayer, Fr., Rauterberg, E., Knippenberg, E., Schwarze, P., Szonntag, E., Lepper, W., Stollenwerk, W., Vahlkampf, E., and Wijkström, T.

Published
1939
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170. Critical illness due to 2009 A/H1N1 influenza in pregnant and postpartum women: population based cohort study

Author

Seppelt, I, Sullivan, E, Bellomo, R, Ellwood, D, Finfer, S, Howe, B, Knight, M, McArthur, C, McDonnell, N, McLintock, C, Morgan, TJ, Morrison, S, Nguyen, N, Peek, MJ, Pollock, W, Vaughan, G, Wang, YA, Web, SAR, Pettila, V, Bailey, M, Cooper, DJ, Cretikos, M, Davies, AR, Harrigan, PWJ, Hart, GK, Iredell, J, Mitchell, I, Nichol, A, Paterson, DL, Peake, S, Richards, B, Stephens, D, Turner, A, Yung, M, Homer, C, Pulver, LJ, Elliot, E, Ho, T, Thompson, J, Zurynski, Y, Callaway, L, Welsh, A, Oats, J, Gupta, B, Hague, W, McKee, A, McGuinness, S, Parke, R, Whitley, A, Newby, L, Simmonds, C, Eastwood, G, Peck, L, Fletcher, J, Boschert, C, Smith, J, Bennett, G, Ong, L, Nand, K, Reece, G, Sara, T, Ernest, D, Eliott, S, Sidhu, J, Carroll, A, Richmond, S, Wenck, D, Bishop, G, Ashley, R, Crowfoot, E, Henderson, S, Mehrtens, J, Fizzell, J, Faithfull, S, Baynes, T, Bersten, A, Ryan, E, Scroggs, S, Blythe, D, Palermo, A, Bortz, P, Lodding, K, Mott, M, Vagg, S, Frengley, R, Haslam, A, La Pine, M, Bingham, T, Cavill, D, Jennings, B, Parr, M, Micallef, S, Chaplin, J, Gregory, K, Presneill, J, Sutton, J, Horsley, C, Tai, J, Tilsley, A, Crozier, T, Galt, P, Reilly, M, Rockell, J, Hoyling, L, Weisbrodt, L, Bell, J, Flanagan, A, Laing, J, Duke, G, Parkes, M, Carr, J, Lambert, J, Boots, R, Lassig-Smith, M, McLaine, J, Thomas, J, Winter, S, Barge, D, Caf, T, Harley, N, MacIsaac, C, Bird, S, Raper, R, Chamberlain, J, Gould, A, McEntaggart, G, Gattas, D, Rajbhandari, D, Rees, C, Baker, S, Bicknell, A, Roberts, B, Nair, P, Reynolds, C, Evans, J, Gordon, G, Jones, L, Radtke, S, Andrews, L, Elder, R, Hicks, P, Mackle, D, Boyd, R, Mudaliar, Y, Nayyar, V, Skelly, C, Stachowski, E, Sterba, M, Johnson, B, and Robinson, J

Subjects
Adult, Critical Care, Adolescent, Critical Illness, Pregnancy Outcome, Australia, Prenatal Care, Cohort Studies, Young Adult, Influenza A Virus, H1N1 Subtype, Risk Factors, Pregnancy, General & Internal Medicine, Influenza, Human, Humans, Female, Pregnancy Complications, Infectious, New Zealand
Published
2010

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