151. Development of a synchronous recording and photo-stimulating electrode in multiple brain neurons
- Author
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Qingping Zhang, Wei Jing, Shiping Wu, Mengzheng Zhu, Jingrui Jiang, Xiang Liu, Dian Yu, Long Cheng, Bin Feng, Jianbin Wen, Feng Xiong, Youming Lu, and Huiyun Du
- Subjects
electrophysiological recording ,optogenetic ,multichannel recording ,default mode network ,brain network ,neural circuit ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
The investigation of brain networks and neural circuits involves the crucial aspects of observing and modulating neurophysiological activity. Recently, opto-electrodes have emerged as an efficient tool for electrophysiological recording and optogenetic stimulation, which has greatly facilitated the analysis of neural coding. However, implantation and electrode weight control have posed significant challenges in achieving long-term and multi-regional brain recording and stimulation. To address this issue, we have developed a mold and custom-printed circuit board-based opto-electrode. We report successful opto-electrode placement and high-quality electrophysiological recordings from the default mode network (DMN) of the mouse brain. This novel opto-electrode facilitates synchronous recording and stimulation in multiple brain regions and holds promise for advancing future research on neural circuits and networks.
- Published
- 2023
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