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153. Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD

Author

Sub String Theory Cosmology and ElemPart, Leerstoel Hout, Experimental psychopathology, Yu, Dongmei, Mathews, Carol A, Scharf, Jeremiah M, Neale, Benjamin M, Davis, Lea K, Gamazon, Eric R, Derks, Eske M, Evans, Patrick, Edlund, Christopher K, Crane, Jacquelyn, Fagerness, Jesen A, Osiecki, Lisa, Gallagher, Patience, Gerber, Gloria, Haddad, Stephen, Illmann, Cornelia, McGrath, Lauren M, Mayerfeld, Catherine, Arepalli, Sampath, Barlassina, Cristina, Barr, Cathy L, Bellodi, Laura, Benarroch, Fortu, Berrió, Gabriel Bedoya, Bienvenu, O Joseph, Black, Donald W, Bloch, Michael H, Brentani, Helena, Bruun, Ruth D, Budman, Cathy L, Camarena, Beatriz, Campbell, Desmond D, Cappi, Carolina, Silgado, Julio C Cardona, Cavallini, Maria C, Chavira, Denise A, Chouinard, Sylvain, Cook, Edwin H, Cookson, M R, Coric, Vladimir, Cullen, Bernadette, Cusi, Daniele, Delorme, Richard, Denys, Damiaan, Dion, Yves, Eapen, Valsama, Egberts, Karin, Falkai, Peter, Fernandez, Thomas, Fournier, Eduardo, Garrido, Helena, Geller, Daniel, Gilbert, Donald L, Girard, Simon L, Grabe, Hans J, Grados, Marco A, Greenberg, Benjamin D, Gross-Tsur, Varda, Grünblatt, Edna, Hardy, John, Heiman, Gary A, Hemmings, Sian M J, Herrera, Luis D, Hezel, Dianne M, Hoekstra, Pieter J, Jankovic, Joseph, Kennedy, James L, King, Robert A, Konkashbaev, Anuar I, Kremeyer, Barbara, Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F, Lennertz, Leonhard, Liu, Chunyu, Lochner, Christine, Lowe, Thomas L, Lupoli, Sara, Macciardi, Fabio, Maier, Wolfgang, Manunta, Paolo, Marconi, Maurizio, McCracken, James T, Mesa Restrepo, Sandra C, Moessner, Rainald, Moorjani, Priya, Morgan, Jubel, Muller, Heike, Murphy, Dennis L, Naarden, Allan L, Nurmi, Erika, Ochoa, William Cornejo, Ophoff, Roel A, Pakstis, Andrew J, Pato, Michele T, Pato, Carlos N, Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Rauch, Scott L, Renner, Tobias, Reus, Victor I, Richter, Margaret A, Riddle, Mark A, Robertson, Mary M, Romero, Roxana, Rosário, Maria C, Rosenberg, David, Ruhrmann, Stephan, Sabatti, Chiara, Salvi, Erika, Sampaio, Aline S, Samuels, Jack, Sandor, Paul, Service, Susan K, Sheppard, Brooke, Singer, Harvey S, Smit, Jan H, Stein, Dan J, Strengman, Eric, Tischfield, Jay A, Turiel, Maurizio, Valencia Duarte, Ana V, Vallada, Homero, Veenstra-VanderWeele, Jeremy, Walitza, Susanne, Wang, Ying, Weale, Mike, Weiss, Robert, Wendland, Jens R, Westenberg, Herman G M, Shugart, Yin Yao, Hounie, Ana G, Miguel, Euripedes C, Nicolini, Humberto, Wagner, Michael, Ruiz-Linares, Andres, Cath, Danielle C, McMahon, William, Posthuma, Danielle, Oostra, Ben A, Nestadt, Gerald, Rouleau, Guy A, Purcell, Shaun, Jenike, Michael A, Heutink, Peter, Hanna, Gregory L, Conti, David V, Arnold, Paul D, Freimer, Nelson B, Stewart, S Evelyn, Knowles, James A, Cox, Nancy J, Pauls, David L, Sub String Theory Cosmology and ElemPart, Leerstoel Hout, Experimental psychopathology, Yu, Dongmei, Mathews, Carol A, Scharf, Jeremiah M, Neale, Benjamin M, Davis, Lea K, Gamazon, Eric R, Derks, Eske M, Evans, Patrick, Edlund, Christopher K, Crane, Jacquelyn, Fagerness, Jesen A, Osiecki, Lisa, Gallagher, Patience, Gerber, Gloria, Haddad, Stephen, Illmann, Cornelia, McGrath, Lauren M, Mayerfeld, Catherine, Arepalli, Sampath, Barlassina, Cristina, Barr, Cathy L, Bellodi, Laura, Benarroch, Fortu, Berrió, Gabriel Bedoya, Bienvenu, O Joseph, Black, Donald W, Bloch, Michael H, Brentani, Helena, Bruun, Ruth D, Budman, Cathy L, Camarena, Beatriz, Campbell, Desmond D, Cappi, Carolina, Silgado, Julio C Cardona, Cavallini, Maria C, Chavira, Denise A, Chouinard, Sylvain, Cook, Edwin H, Cookson, M R, Coric, Vladimir, Cullen, Bernadette, Cusi, Daniele, Delorme, Richard, Denys, Damiaan, Dion, Yves, Eapen, Valsama, Egberts, Karin, Falkai, Peter, Fernandez, Thomas, Fournier, Eduardo, Garrido, Helena, Geller, Daniel, Gilbert, Donald L, Girard, Simon L, Grabe, Hans J, Grados, Marco A, Greenberg, Benjamin D, Gross-Tsur, Varda, Grünblatt, Edna, Hardy, John, Heiman, Gary A, Hemmings, Sian M J, Herrera, Luis D, Hezel, Dianne M, Hoekstra, Pieter J, Jankovic, Joseph, Kennedy, James L, King, Robert A, Konkashbaev, Anuar I, Kremeyer, Barbara, Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F, Lennertz, Leonhard, Liu, Chunyu, Lochner, Christine, Lowe, Thomas L, Lupoli, Sara, Macciardi, Fabio, Maier, Wolfgang, Manunta, Paolo, Marconi, Maurizio, McCracken, James T, Mesa Restrepo, Sandra C, Moessner, Rainald, Moorjani, Priya, Morgan, Jubel, Muller, Heike, Murphy, Dennis L, Naarden, Allan L, Nurmi, Erika, Ochoa, William Cornejo, Ophoff, Roel A, Pakstis, Andrew J, Pato, Michele T, Pato, Carlos N, Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Rauch, Scott L, Renner, Tobias, Reus, Victor I, Richter, Margaret A, Riddle, Mark A, Robertson, Mary M, Romero, Roxana, Rosário, Maria C, Rosenberg, David, Ruhrmann, Stephan, Sabatti, Chiara, Salvi, Erika, Sampaio, Aline S, Samuels, Jack, Sandor, Paul, Service, Susan K, Sheppard, Brooke, Singer, Harvey S, Smit, Jan H, Stein, Dan J, Strengman, Eric, Tischfield, Jay A, Turiel, Maurizio, Valencia Duarte, Ana V, Vallada, Homero, Veenstra-VanderWeele, Jeremy, Walitza, Susanne, Wang, Ying, Weale, Mike, Weiss, Robert, Wendland, Jens R, Westenberg, Herman G M, Shugart, Yin Yao, Hounie, Ana G, Miguel, Euripedes C, Nicolini, Humberto, Wagner, Michael, Ruiz-Linares, Andres, Cath, Danielle C, McMahon, William, Posthuma, Danielle, Oostra, Ben A, Nestadt, Gerald, Rouleau, Guy A, Purcell, Shaun, Jenike, Michael A, Heutink, Peter, Hanna, Gregory L, Conti, David V, Arnold, Paul D, Freimer, Nelson B, Stewart, S Evelyn, Knowles, James A, Cox, Nancy J, and Pauls, David L

Published
2015

155. OBSESSIVE-COMPULSIVE PERSONALITY DISORDER: EVIDENCE FOR TWO DIMENSIONS

Author

Riddle, Mark A., primary, Maher, Brion S., additional, Wang, Ying, additional, Grados, Marco, additional, Bienvenu, O. Joseph, additional, Goes, Fernando S., additional, Cullen, Bernadette, additional, Murphy, Dennis L., additional, Rauch, Scott L., additional, Greenberg, Benjamin D., additional, Knowles, James A., additional, McCracken, James T., additional, Pinto, Anthony, additional, Piacentini, John, additional, Pauls, David L., additional, Rasmussen, Steven A., additional, Shugart, Yin Yao, additional, Nestadt, Gerald, additional, and Samuels, Jack, additional

Published
2015
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160. Delirium Transitions in the Medical ICU

Author

Kamdar, Biren B., primary, Niessen, Timothy, additional, Colantuoni, Elizabeth, additional, King, Lauren M., additional, Neufeld, Karin J., additional, Bienvenu, O. Joseph, additional, Rowden, Annette M., additional, Collop, Nancy A., additional, and Needham, Dale M., additional

Published
2015
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161. The stability of DSM personality disorders over twelve to eighteen years

Author

Nestadt, Gerald, Di, Chongzhi, Samuels, J F, Bienvenu, O Joseph, Reti, I M, Costa, Paulo, Eaton, William W, Bandeen-Roche, Karen, University of Zurich, and Nestadt, Gerald

Subjects
2738 Psychiatry and Mental Health, Psychiatry and Mental health, 10093 Institute of Psychology, 150 Psychology, 2803 Biological Psychiatry, Biological Psychiatry
Published
2010
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162. Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study

Author

Leerstoel Hout, Sub String Theory Cosmology and ElemPart, Experimental psychopathology, McGrath, Lauren M, Yu, Dongmei, Marshall, Christian, Davis, Lea K, Thiruvahindrapuram, Bhooma, Li, Bingbin, Cappi, Carolina, Gerber, Gloria, Wolf, Aaron, Schroeder, Frederick A, Osiecki, Lisa, O'Dushlaine, Colm, Kirby, Andrew, Illmann, Cornelia, Haddad, Stephen, Gallagher, Patience, Fagerness, Jesen A, Barr, Cathy L, Bellodi, Laura, Benarroch, Fortu, Bienvenu, O Joseph, Black, Donald W, Bloch, Michael H, Bruun, Ruth D, Budman, Cathy L, Camarena, Beatriz, Cath, Danielle C, Cavallini, Maria C, Chouinard, Sylvain, Coric, Vladimir, Cullen, Bernadette, Delorme, Richard, Denys, Damiaan, Derks, Eske M, Dion, Yves, Rosário, Maria C, Eapen, Valsama, Evans, Patrick, Falkai, Peter, Fernandez, Thomas V, Garrido, Helena, Geller, Daniel, Grabe, Hans J, Grados, Marco A, Greenberg, Benjamin D, Gross-Tsur, Varda, Grünblatt, Edna, Heiman, Gary A, Hemmings, Sian M J, Herrera, Luis D, Hounie, Ana G, Jankovic, Joseph, Kennedy, James L, King, Robert A, Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F, Lennertz, Leonhard, Lochner, Christine, Lowe, Thomas L, Lyon, Gholson J, Macciardi, Fabio, Maier, Wolfgang, McCracken, James T, McMahon, William, Murphy, Dennis L, Naarden, Allan L, Neale, Benjamin M, Nurmi, Erika, Pakstis, Andrew J, Pato, Michele T, Pato, Carlos N, Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Reus, Victor I, Richter, Margaret A, Riddle, Mark, Robertson, Mary M, Rosenberg, David, Rouleau, Guy A, Ruhrmann, Stephan, Sampaio, Aline S, Samuels, Jack, Sandor, Paul, Sheppard, Brooke, Singer, Harvey S, Smit, Jan H, Stein, Dan J, Tischfield, Jay A, Vallada, Homero, Veenstra-VanderWeele, Jeremy, Walitza, Susanne, Wang, Ying, Wendland, Jens R, Shugart, Yin Yao, Miguel, Euripedes C, Nicolini, Humberto, Oostra, Ben A, Moessner, Rainald, Wagner, Michael, Ruiz-Linares, Andres, Heutink, Peter, Nestadt, Gerald, Freimer, Nelson, Petryshen, Tracey, Posthuma, Danielle, Jenike, Michael A, Cox, Nancy J, Hanna, Gregory L, Brentani, Helena, Scherer, Stephen W, Arnold, Paul D, Stewart, S Evelyn, Mathews, Carol A, Knowles, James A, Cook, Edwin H, Pauls, David L, Wang, Kai, Scharf, Jeremiah M, Leerstoel Hout, Sub String Theory Cosmology and ElemPart, Experimental psychopathology, McGrath, Lauren M, Yu, Dongmei, Marshall, Christian, Davis, Lea K, Thiruvahindrapuram, Bhooma, Li, Bingbin, Cappi, Carolina, Gerber, Gloria, Wolf, Aaron, Schroeder, Frederick A, Osiecki, Lisa, O'Dushlaine, Colm, Kirby, Andrew, Illmann, Cornelia, Haddad, Stephen, Gallagher, Patience, Fagerness, Jesen A, Barr, Cathy L, Bellodi, Laura, Benarroch, Fortu, Bienvenu, O Joseph, Black, Donald W, Bloch, Michael H, Bruun, Ruth D, Budman, Cathy L, Camarena, Beatriz, Cath, Danielle C, Cavallini, Maria C, Chouinard, Sylvain, Coric, Vladimir, Cullen, Bernadette, Delorme, Richard, Denys, Damiaan, Derks, Eske M, Dion, Yves, Rosário, Maria C, Eapen, Valsama, Evans, Patrick, Falkai, Peter, Fernandez, Thomas V, Garrido, Helena, Geller, Daniel, Grabe, Hans J, Grados, Marco A, Greenberg, Benjamin D, Gross-Tsur, Varda, Grünblatt, Edna, Heiman, Gary A, Hemmings, Sian M J, Herrera, Luis D, Hounie, Ana G, Jankovic, Joseph, Kennedy, James L, King, Robert A, Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F, Lennertz, Leonhard, Lochner, Christine, Lowe, Thomas L, Lyon, Gholson J, Macciardi, Fabio, Maier, Wolfgang, McCracken, James T, McMahon, William, Murphy, Dennis L, Naarden, Allan L, Neale, Benjamin M, Nurmi, Erika, Pakstis, Andrew J, Pato, Michele T, Pato, Carlos N, Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Reus, Victor I, Richter, Margaret A, Riddle, Mark, Robertson, Mary M, Rosenberg, David, Rouleau, Guy A, Ruhrmann, Stephan, Sampaio, Aline S, Samuels, Jack, Sandor, Paul, Sheppard, Brooke, Singer, Harvey S, Smit, Jan H, Stein, Dan J, Tischfield, Jay A, Vallada, Homero, Veenstra-VanderWeele, Jeremy, Walitza, Susanne, Wang, Ying, Wendland, Jens R, Shugart, Yin Yao, Miguel, Euripedes C, Nicolini, Humberto, Oostra, Ben A, Moessner, Rainald, Wagner, Michael, Ruiz-Linares, Andres, Heutink, Peter, Nestadt, Gerald, Freimer, Nelson, Petryshen, Tracey, Posthuma, Danielle, Jenike, Michael A, Cox, Nancy J, Hanna, Gregory L, Brentani, Helena, Scherer, Stephen W, Arnold, Paul D, Stewart, S Evelyn, Mathews, Carol A, Knowles, James A, Cook, Edwin H, Pauls, David L, Wang, Kai, and Scharf, Jeremiah M

Published
2014

163. Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study

Author

McGrath, Lauren M., Yu, Dongmei, Marshall, Christian, Davis, Lea K., Thiruvahindrapuram, Bhooma, Li, Bingbin, Cappi, Carolina, Gerber, Gloria, Wolf, Aaron, Schroeder, Frederick A., Osiecki, Lisa, O'Dushlaine, Colm, Kirby, Andrew, Illmann, Cornelia, Haddad, Stephen, Gallagher, Patience, Fagerness, Jesen A., Barr, Cathy L., Bellodi, Laura, Benarroch, Fortu, Bienvenu, O. Joseph, Black, Donald W., Bloch, Michael H., Bruun, Ruth D., Budman, Cathy L., Camarena, Beatriz, Cath, Danielle C., Cavallini, Maria C., Chouinard, Sylvain, Coric, Vladimir, Cullen, Bernadette, Delorme, Richard, Denys, Damiaan, Derks, Eske M., Dion, Yves, Rosario, Maria C., Eapen, Valsama, Evans, Patrick, Falkai, Peter, Fernandez, Thomas V., Garrido, Helena, Geller, Daniel, Grabe, Hans J., Grados, Marco A., Greenberg, Benjamin D., Gross-Tsur, Varda, Gruenblatt, Edna, Heiman, Gary A., Hemmings, Sian M. J., Herrera, Luis D., Hounie, Ana G., Jankovic, Joseph, Kennedy, James L., King, Robert A., Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F., Lennertz, Leonhard, Lochner, Christine, Lowe, Thomas L., Lyon, Gholson J., Macciardi, Fabio, Maier, Wolfgang, McCracken, James T., McMahon, William, Murphy, Dennis L., Naarden, Allan L., Neale, Benjamin M., Nurmi, Erika, Pakstis, Andrew J., Pato, Michele T., Pato, Carlos N., Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Reus, Victor I., Richter, Margaret A., Riddle, Mark, Robertson, Mary M., Rosenberg, David, Rouleau, Guy A., Ruhrmann, Stephan, Sampaio, Aline S., Samuels, Jack, Sandor, Paul, Sheppard, Brooke, Singer, Harvey S., Smit, Jan H., Stein, Dan J., Tischrield, Jay A., Vallada, Homero, Veenstra-VanderWeele, Jeremy, Walitza, Susanne, Wang, Ying, Wendfand, Jens R., Shugart, Yin Yao, Miguel, Euripedes C., Nicolini, Humberto, Oostra, Ben A., Moessner, Rainald, Wagner, Michael, Ruiz-Linares, Andres, Heutink, Peter, Nestadt, Gerald, Freimer, Nelson, Petryshen, Tracey, Posthuma, Danielle, Jenike, Michael A., Cox, Nancy J., Hanna, Gregory L., Brentani, Helena, Scherer, Stephen W., Arnold, Paul D., Stewart, S. Evelyn, Mathews, Carol A., Knowles, James A., Cook, Edwin H., Pauls, David L., Wang, Kai, Scharf, Jeremiah M., McGrath, Lauren M., Yu, Dongmei, Marshall, Christian, Davis, Lea K., Thiruvahindrapuram, Bhooma, Li, Bingbin, Cappi, Carolina, Gerber, Gloria, Wolf, Aaron, Schroeder, Frederick A., Osiecki, Lisa, O'Dushlaine, Colm, Kirby, Andrew, Illmann, Cornelia, Haddad, Stephen, Gallagher, Patience, Fagerness, Jesen A., Barr, Cathy L., Bellodi, Laura, Benarroch, Fortu, Bienvenu, O. Joseph, Black, Donald W., Bloch, Michael H., Bruun, Ruth D., Budman, Cathy L., Camarena, Beatriz, Cath, Danielle C., Cavallini, Maria C., Chouinard, Sylvain, Coric, Vladimir, Cullen, Bernadette, Delorme, Richard, Denys, Damiaan, Derks, Eske M., Dion, Yves, Rosario, Maria C., Eapen, Valsama, Evans, Patrick, Falkai, Peter, Fernandez, Thomas V., Garrido, Helena, Geller, Daniel, Grabe, Hans J., Grados, Marco A., Greenberg, Benjamin D., Gross-Tsur, Varda, Gruenblatt, Edna, Heiman, Gary A., Hemmings, Sian M. J., Herrera, Luis D., Hounie, Ana G., Jankovic, Joseph, Kennedy, James L., King, Robert A., Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F., Lennertz, Leonhard, Lochner, Christine, Lowe, Thomas L., Lyon, Gholson J., Macciardi, Fabio, Maier, Wolfgang, McCracken, James T., McMahon, William, Murphy, Dennis L., Naarden, Allan L., Neale, Benjamin M., Nurmi, Erika, Pakstis, Andrew J., Pato, Michele T., Pato, Carlos N., Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Reus, Victor I., Richter, Margaret A., Riddle, Mark, Robertson, Mary M., Rosenberg, David, Rouleau, Guy A., Ruhrmann, Stephan, Sampaio, Aline S., Samuels, Jack, Sandor, Paul, Sheppard, Brooke, Singer, Harvey S., Smit, Jan H., Stein, Dan J., Tischrield, Jay A., Vallada, Homero, Veenstra-VanderWeele, Jeremy, Walitza, Susanne, Wang, Ying, Wendfand, Jens R., Shugart, Yin Yao, Miguel, Euripedes C., Nicolini, Humberto, Oostra, Ben A., Moessner, Rainald, Wagner, Michael, Ruiz-Linares, Andres, Heutink, Peter, Nestadt, Gerald, Freimer, Nelson, Petryshen, Tracey, Posthuma, Danielle, Jenike, Michael A., Cox, Nancy J., Hanna, Gregory L., Brentani, Helena, Scherer, Stephen W., Arnold, Paul D., Stewart, S. Evelyn, Mathews, Carol A., Knowles, James A., Cook, Edwin H., Pauls, David L., Wang, Kai, and Scharf, Jeremiah M.

Abstract

Objective: Obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) are heritable neurodevelopmental disorders with a partially shared genetic etiology. This study represents the first genome-wide investigation of large (>500 kb), rare (<1%) copy number variants (CNVs) in OCD and the largest genome-wide CNV analysis in TS to date. Method: The primary analyses used a cross-disorder design for 2,699 case patients (1,613 ascertained for OCD, 1,086 ascertained for TS) and 1,789 controls. Parental data facilitated a de novo analysis in 348 OCD trios. Results: Although no global CNV burden was detected in the cross-disorder analysis or in secondary, disease-specific analyses, there was a 3.3-fold increased burden of large deletions previously associated with other neurodevelopmental disorders (p = .09). Half of these neurodevelopmental deletions were located in a single locus, 16p13.11 (5 case patient deletions: 0 control deletions, p = .08 in the current study, p = .025 compared to published controls). Three 16p13.11 deletions were confirmed de novo, providing further support for the etiological significance of this region. The overall OCD de novo rate was 1.4%, which is intermediate between published rates in controls (0.7%) and in individuals with autism or schizophrenia (2-4%). Conclusion: Several converging lines of evidence implicate 16p13.11 deletions in OCD, with weaker evidence for a role in TS. The trend toward increased overall neurodevelopmental CNV burden in TS and OCD suggests that deletions previously associated with other neurodevelopmental disorders may also contribute to these phenotypes.

Published
2014

165. Exploring the Scope of Post–Intensive Care Syndrome Therapy and Care

Author

Elliott, Doug, primary, Davidson, Judy E., additional, Harvey, Maurene A., additional, Bemis-Dougherty, Anita, additional, Hopkins, Ramona O., additional, Iwashyna, Theodore J., additional, Wagner, Jason, additional, Weinert, Craig, additional, Wunsch, Hannah, additional, Bienvenu, O. Joseph, additional, Black, Gary, additional, Brady, Susan, additional, Brodsky, Martin B., additional, Deutschman, Cliff, additional, Doepp, Diana, additional, Flatley, Carl, additional, Fosnight, Sue, additional, Gittler, Michelle, additional, Gomez, Belkys Teresa, additional, Hyzy, Robert, additional, Louis, Deborah, additional, Mandel, Ruth, additional, Maxwell, Carol, additional, Muldoon, Sean R., additional, Perme, Christiane S., additional, Reilly, Cynthia, additional, Robinson, Marla R., additional, Rubin, Eileen, additional, Schmidt, David M., additional, Schuller, Jessica, additional, Scruth, Elizabeth, additional, Siegal, Eric, additional, Spill, Gayle R., additional, Sprenger, Sharon, additional, Straumanis, John P., additional, Sutton, Pat, additional, Swoboda, Sandy M., additional, Twaddle, Martha L., additional, and Needham, Dale M., additional

Published
2014
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167. Focus on long-term cognitive, psychological and physical impairments after critical illness.

Author

Bein, Thomas, Bienvenu, O. Joseph, and Hopkins, Ramona O.

Subjects
*CRITICALLY ill, *SICK leave, *DISABILITIES, *ADULT respiratory distress syndrome
Abstract

The decades from 1990 to 2010 saw a clinical and research focus on technical, pharmaceutical, and scientific advances in intensive care medicine, and the key question was "Will my patient survive or die?" In consequence, a careful anamnesis of psychiatric history in ARDS patients may help identify patients at highest risk for prolonged psychiatric morbidity [[5]]. Comparable to ARDS, sepsis is a potentially life-threatening disease that challenges staff and is associated with high mortality and morbidity. Thompson et al. compared long-term outcomes of patients who survived sepsis with the outcome of non-septic critical illness survivors [[7]]. [Extracted from the article]

Published
2019
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168. The anxious patient

Author

Bone, Ashley D., primary, Bienvenu, O. Joseph, additional, Chanmugam, Arjun, additional, Triplett, Patrick, additional, and Kelen, Gabor, additional

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169. Hoarding in children and adolescents with obsessive–compulsive disorder

Author

Samuels, Jack, primary, Grados, Marco A., additional, Riddle, Mark A., additional, Bienvenu, O. Joseph, additional, Goes, Fernando S., additional, Cullen, Bernadette, additional, Wang, Ying, additional, Greenberg, Benjamin D., additional, Fyer, Abby J., additional, McCracken, James T., additional, Geller, Dan, additional, Murphy, Dennis L., additional, Knowles, James A., additional, Rasmussen, Steven A., additional, McLaughlin, Nicole C., additional, Piacentini, John, additional, Pauls, David L., additional, Stewart, S. Evelyn, additional, Shugart, Yin-Yao, additional, Maher, Brion, additional, Pulver, Ann E., additional, and Nestadt, Gerald, additional

Published
2014
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172. Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study

Author

McGrath, Lauren M., primary, Yu, Dongmei, additional, Marshall, Christian, additional, Davis, Lea K., additional, Thiruvahindrapuram, Bhooma, additional, Li, Bingbin, additional, Cappi, Carolina, additional, Gerber, Gloria, additional, Wolf, Aaron, additional, Schroeder, Frederick A., additional, Osiecki, Lisa, additional, O'Dushlaine, Colm, additional, Kirby, Andrew, additional, Illmann, Cornelia, additional, Haddad, Stephen, additional, Gallagher, Patience, additional, Fagerness, Jesen A., additional, Barr, Cathy L., additional, Bellodi, Laura, additional, Benarroch, Fortu, additional, Bienvenu, O. Joseph, additional, Black, Donald W., additional, Bloch, Michael H., additional, Bruun, Ruth D., additional, Budman, Cathy L., additional, Camarena, Beatriz, additional, Cath, Danielle C., additional, Cavallini, Maria C., additional, Chouinard, Sylvain, additional, Coric, Vladimir, additional, Cullen, Bernadette, additional, Delorme, Richard, additional, Denys, Damiaan, additional, Derks, Eske M., additional, Dion, Yves, additional, Rosário, Maria C., additional, Eapen, Valsama, additional, Evans, Patrick, additional, Falkai, Peter, additional, Fernandez, Thomas V., additional, Garrido, Helena, additional, Geller, Daniel, additional, Grabe, Hans J., additional, Grados, Marco A., additional, Greenberg, Benjamin D., additional, Gross-Tsur, Varda, additional, Grünblatt, Edna, additional, Heiman, Gary A., additional, Hemmings, Sian M.J., additional, Herrera, Luis D., additional, Hounie, Ana G., additional, Jankovic, Joseph, additional, Kennedy, James L., additional, King, Robert A., additional, Kurlan, Roger, additional, Lanzagorta, Nuria, additional, Leboyer, Marion, additional, Leckman, James F., additional, Lennertz, Leonhard, additional, Lochner, Christine, additional, Lowe, Thomas L., additional, Lyon, Gholson J., additional, Macciardi, Fabio, additional, Maier, Wolfgang, additional, McCracken, James T., additional, McMahon, William, additional, Murphy, Dennis L., additional, Naarden, Allan L., additional, Neale, Benjamin M., additional, Nurmi, Erika, additional, Pakstis, Andrew J., additional, Pato, Michele T., additional, Pato, Carlos N., additional, Piacentini, John, additional, Pittenger, Christopher, additional, Pollak, Yehuda, additional, Reus, Victor I., additional, Richter, Margaret A., additional, Riddle, Mark, additional, Robertson, Mary M., additional, Rosenberg, David, additional, Rouleau, Guy A., additional, Ruhrmann, Stephan, additional, Sampaio, Aline S., additional, Samuels, Jack, additional, Sandor, Paul, additional, Sheppard, Brooke, additional, Singer, Harvey S., additional, Smit, Jan H., additional, Stein, Dan J., additional, Tischfield, Jay A., additional, Vallada, Homero, additional, Veenstra-VanderWeele, Jeremy, additional, Walitza, Susanne, additional, Wang, Ying, additional, Wendland, Jens R., additional, Shugart, Yin Yao, additional, Miguel, Euripedes C., additional, Nicolini, Humberto, additional, Oostra, Ben A., additional, Moessner, Rainald, additional, Wagner, Michael, additional, Ruiz-Linares, Andres, additional, Heutink, Peter, additional, Nestadt, Gerald, additional, Freimer, Nelson, additional, Petryshen, Tracey, additional, Posthuma, Danielle, additional, Jenike, Michael A., additional, Cox, Nancy J., additional, Hanna, Gregory L., additional, Brentani, Helena, additional, Scherer, Stephen W., additional, Arnold, Paul D., additional, Stewart, S. Evelyn, additional, Mathews, Carol A., additional, Knowles, James A., additional, Cook, Edwin H., additional, Pauls, David L., additional, Wang, Kai, additional, and Scharf, Jeremiah M., additional

Published
2014
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173. Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive–compulsive disorder: Results from the OCD Collaborative Genetics Study

Author

Samuels, Jack, primary, Shugart, Yin Yao, additional, Wang, Ying, additional, Grados, Marco A., additional, Bienvenu, O. Joseph, additional, Pinto, Anthony, additional, Rauch, Scott L., additional, Greenberg, Benjamin D., additional, Knowles, James A., additional, Fyer, Abby J., additional, Piacentini, John, additional, Pauls, David L., additional, Cullen, Bernadette, additional, Rasmussen, Steven A., additional, Stewart, S. Evelyn, additional, Geller, Dan A., additional, Maher, Brion S., additional, Goes, Fernando S., additional, Murphy, Dennis L., additional, McCracken, James T., additional, Riddle, Mark A., additional, and Nestadt, Gerald, additional

Published
2014
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179. Reducing Deep Sedation and Delirium in Acute Lung Injury Patients

Author

Hager, David N., primary, Dinglas, Victor D., additional, Subhas, Shilta, additional, Rowden, Annette M., additional, Neufeld, Karin J., additional, Bienvenu, O. Joseph, additional, Touradji, Pegah, additional, Colantuoni, Elizabeth, additional, Reddy, Dereddi R.S., additional, Brower, Roy G., additional, and Needham, Dale M., additional

Published
2013
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181. The Effect of a Quality Improvement Intervention on Perceived Sleep Quality and Cognition in a Medical ICU*

Author

Kamdar, Biren B., primary, King, Lauren M., additional, Collop, Nancy A., additional, Sakamuri, Sruthi, additional, Colantuoni, Elizabeth, additional, Neufeld, Karin J., additional, Bienvenu, O. Joseph, additional, Rowden, Annette M., additional, Touradji, Pegah, additional, Brower, Roy G., additional, and Needham, Dale M., additional

Published
2013
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184. Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers.

Author

Herridge, Margaret, Moss, Marc, Hough, Catherine, Hopkins, Ramona, Rice, Todd, Bienvenu, O., Azoulay, Elie, Herridge, Margaret S, Hough, Catherine L, Hopkins, Ramona O, Rice, Todd W, and Bienvenu, O Joseph

Subjects
INTENSIVE care units, HEALTH outcome assessment, ASTHENIA, ADULT respiratory distress syndrome treatment, NEUROPSYCHOLOGICAL tests, PATIENT-family relations, MEDICAL care, AFFECTIVE disorders, PSYCHOLOGY of caregivers, COGNITION disorders, FUNCTIONAL assessment, POLYNEUROPATHIES, POST-traumatic stress disorder, QUALITY of life, ADULT respiratory distress syndrome, PULMONARY function tests, MUSCLE weakness, DISEASE complications, PSYCHOLOGY
Abstract

Outcomes after acute respiratory distress syndrome (ARDS) are similar to those of other survivors of critical illness and largely affect the nerve, muscle, and central nervous system but also include a constellation of varied physical devastations ranging from contractures and frozen joints to tooth loss and cosmesis. Compromised quality of life is related to a spectrum of impairment of physical, social, emotional, and neurocognitive function and to a much lesser extent discrete pulmonary disability. Intensive care unit-acquired weakness (ICUAW) is ubiquitous and includes contributions from both critical illness polyneuropathy and myopathy, and recovery from these lesions may be incomplete at 5 years after ICU discharge. Cognitive impairment in ARDS survivors ranges from 70 to 100 % at hospital discharge, 46 to 80 % at 1 year, and 20 % at 5 years, and mood disorders including depression and post-traumatic stress disorder (PTSD) are also sustained and prevalent. Robust multidisciplinary and longitudinal interventions that improve these outcomes are still uncertain and data in our literature are conflicting. Studies are needed in family members of ARDS survivors to better understand long-term outcomes of the post-ICU family syndrome and to evaluate how it affects patient recovery. [ABSTRACT FROM AUTHOR]

Published
2016
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186. OBSESSIVE-COMPULSIVE PERSONALITY DISORDER: EVIDENCE FOR TWO DIMENSIONS.

Author

Riddle, Mark A., Maher, Brion S., Wang, Ying, Grados, Marco, Bienvenu, O. Joseph, Goes, Fernando S., Cullen, Bernadette, Murphy, Dennis L., Rauch, Scott L., Greenberg, Benjamin D., Knowles, James A., McCracken, James T., Pinto, Anthony, Piacentini, John, Pauls, David L., Rasmussen, Steven A., Shugart, Yin Yao, Nestadt, Gerald, and Samuels, Jack

Subjects
DIAGNOSIS of obsessive-compulsive disorder, LOCUS (Genetics), COMPULSIVE hoarding, PERSONALITY disorders, EXPLORATORY factor analysis, STATISTICAL correlation, COMPULSIVE behavior, FACTOR analysis, RESEARCH funding
Abstract

Background: To determine possible dimensions that underlie obsessive-compulsive personality disorder (OCPD) and to investigate their clinical correlates, familiality, and genetic linkage.Methods: Participants were selected from 844 adults assessed with the Structured Instrument for the Diagnosis of DSM-IV Personality Disorders (SIDP) in the OCD Collaborative Genetics Study (OCGS) that targeted families with obsessive-compulsive disorder (OCD) affected sibling pairs. We conducted an exploratory factor analysis, which included the eight SIDP-derived DSM-IV OCPD traits and the indecision trait from the DSM-III, assessed clinical correlates, and estimated sib-sib correlations to evaluate familiality of the factors. Using MERLIN and MINX, we performed genome-wide quantitative trait locus (QTL) linkage analysis to test for allele sharing among individuals.Results: Two factors were identified: Factor 1: order/control (perfectionism, excessive devotion to work, overconscientiousness, reluctance to delegate, and rigidity); and Factor 2: hoarding/indecision (inability to discard and indecisiveness). Factor 1 score was associated with poor insight, whereas Factor 2 score was associated with task incompletion. A significant sib-sib correlation was found for Factor 2 (rICC = .354, P < .0001) but not Factor 1 (rICC = .129, P = .084). The linkage findings were different for the two factors. When Factor 2 was analyzed as a quantitative trait, a strong signal was detected on chromosome 10 at marker d10s1221: KAC LOD = 2.83, P = .0002; and marker d10s1225: KAC LOD = 1.35, P = .006.Conclusions: The results indicate two factors of OCPD, order/control and hoarding/indecision. The hoarding/indecision factor is familial and shows modest linkage to a region on chromosome 10. [ABSTRACT FROM AUTHOR]

Published
2016
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191. Improving long-term outcomes after discharge from intensive care unit

Author

Needham, Dale M., primary, Davidson, Judy, additional, Cohen, Henry, additional, Hopkins, Ramona O., additional, Weinert, Craig, additional, Wunsch, Hannah, additional, Zawistowski, Christine, additional, Bemis-Dougherty, Anita, additional, Berney, Susan C., additional, Bienvenu, O. Joseph, additional, Brady, Susan L., additional, Brodsky, Martin B., additional, Denehy, Linda, additional, Elliott, Doug, additional, Flatley, Carl, additional, Harabin, Andrea L., additional, Jones, Christina, additional, Louis, Deborah, additional, Meltzer, Wendy, additional, Muldoon, Sean R., additional, Palmer, Jeffrey B., additional, Perme, Christiane, additional, Robinson, Marla, additional, Schmidt, David M., additional, Scruth, Elizabeth, additional, Spill, Gayle R., additional, Storey, C. Porter, additional, Render, Marta, additional, Votto, John, additional, and Harvey, Maurene A., additional

Published
2012
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194. Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder

Author

Samuels, Jack, primary, Wang, Ying, additional, Riddle, Mark A., additional, Greenberg, Benjamin D., additional, Fyer, Abby J., additional, McCracken, James T., additional, Rauch, Scott L., additional, Murphy, Dennis L., additional, Grados, Marco A., additional, Knowles, James A., additional, Piacentini, John, additional, Cullen, Bernadette, additional, Bienvenu, O. Joseph, additional, Rasmussen, Steven A., additional, Geller, Daniel, additional, Pauls, David L., additional, Liang, Kung-Yee, additional, Shugart, Yin Y., additional, and Nestadt, Gerald, additional

Published
2011
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196. Is Obsessive-Compulsive Disorder an Anxiety Disorder, and what, if any, are Spectrum Conditions? A family-study perspective

Author

Bienvenu, O. Joseph, primary, Samuels, Jack F., additional, Wuyek, Lisa A., additional, Liang, Kung-Yee, additional, Wang, Ying, additional, Grados, Marco A., additional, Cullen, Bernadette A., additional, Riddle, Mark A., additional, Greenberg, Benjamin D., additional, Rasmussen, Steven A., additional, Fyer, Abby J., additional, Pinto, Anthony, additional, Rauch, Scott L., additional, Pauls, David L., additional, McCracken, James T., additional, Piacentini, John, additional, Murphy, Dennis L., additional, Knowles, James A., additional, and Nestadt, Gerald, additional

Published
2011
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200. Should OCD be classified as an anxiety disorder in DSM-V?

Author

Stein, Dan J., primary, Fineberg, Naomi A., additional, Bienvenu, O. Joseph, additional, Denys, Damiaan, additional, Lochner, Christine, additional, Nestadt, Gerald, additional, Leckman, James F., additional, Rauch, Scott L., additional, and Phillips, Katharine A., additional

Published
2010
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