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151. Breast Cancer Risk After Recent Childbirth : A Pooled Analysis of 15 Prospective Studies

Author

Nichols, Hazel B, Schoemaker, Minouk J, Cai, Jianwen, Xu, Jiawei, Wright, Lauren B, Brook, Mark N, Jones, Michael E, Adami, Hans-Olov, Baglietto, Laura, Bertrand, Kimberly A, Blot, William J, Boutron-Ruault, Marie-Christine, Dorronsoro, Miren, Dossus, Laure, Eliassen, A Heather, Giles, Graham G, Gram, Inger T, Hankinson, Susan E, Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J, Kitahara, Cari M, Larsson, Susanna C., Linet, Martha, Merritt, Melissa A, Milne, Roger L, Pala, Valeria, Palmer, Julie R, Peeters, Petra H, Riboli, Elio, Sund, Malin, Tamimi, Rulla M, Tjønneland, Anne, Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Zheng, Wei, Weinberg, Clarice R, Swerdlow, Anthony J, Sandler, Dale P, Nichols, Hazel B, Schoemaker, Minouk J, Cai, Jianwen, Xu, Jiawei, Wright, Lauren B, Brook, Mark N, Jones, Michael E, Adami, Hans-Olov, Baglietto, Laura, Bertrand, Kimberly A, Blot, William J, Boutron-Ruault, Marie-Christine, Dorronsoro, Miren, Dossus, Laure, Eliassen, A Heather, Giles, Graham G, Gram, Inger T, Hankinson, Susan E, Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J, Kitahara, Cari M, Larsson, Susanna C., Linet, Martha, Merritt, Melissa A, Milne, Roger L, Pala, Valeria, Palmer, Julie R, Peeters, Petra H, Riboli, Elio, Sund, Malin, Tamimi, Rulla M, Tjønneland, Anne, Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Zheng, Wei, Weinberg, Clarice R, Swerdlow, Anthony J, and Sandler, Dale P

Abstract

Background: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or specific tumor subtype has rarely been evaluated. Objective: To characterize breast cancer risk in relation to recent childbirth. Design: Pooled analysis of individual-level data from 15 prospective cohort studies. Setting: The international Premenopausal Breast Cancer Collaborative Group. Participants: Women younger than 55 years. Measurements: During 9.6 million person-years of follow-up, 18 826 incident cases of breast cancer were diagnosed. Hazard ratios (HRs) and 95% CIs for breast cancer were calculated using Cox proportional hazards regression. Results: Compared with nulliparous women, parous women had an HR for breast cancer that peaked about 5 years after birth (HR, 1.80 [95% CI, 1.63 to 1.99]) before decreasing to 0.77 (CI, 0.67 to 0.88) after 34 years. The association crossed over from positive to negative about 24 years after birth. The overall pattern was driven by estrogen receptor (ER)-positive breast cancer; no crossover was seen for ER-negative cancer. Increases in breast cancer risk after childbirth were pronounced when combined with a family history of breast cancer and were greater for women who were older at first birth or who had more births. Breastfeeding did not modify overall risk patterns. Limitations: Breast cancer diagnoses during pregnancy were not uniformly distinguishable from early postpartum diagnoses. Data on human epidermal growth factor receptor 2 (HER2) oncogene overexpression were limited. Conclusion: Compared with nulliparous women, parous women have an increased risk for breast cancer for more than 20 years after childbirth. Health care providers should consider recent childbirth a risk factor for breast cancer in young women. Primary Funding Source: The Avon Foundation, the National Institute of Environmental

Published
2019
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152. Ultraviolet radiation exposure and breast cancer risk in the Nurses' Health Study II.

Author

VoPham, Trang, VoPham, Trang, Bertrand, Kimberly A, DuPré, Natalie C, James, Peter, Vieira, Verónica M, Tamimi, Rulla M, Laden, Francine, Hart, Jaime E, VoPham, Trang, VoPham, Trang, Bertrand, Kimberly A, DuPré, Natalie C, James, Peter, Vieira, Verónica M, Tamimi, Rulla M, Laden, Francine, and Hart, Jaime E

Abstract

BackgroundUltraviolet (UV) radiation exposure, the primary source of vitamin D for most people, may reduce breast cancer risk. To date, epidemiologic studies have shown inconsistent results.MethodsThe Nurses' Health Study II is a U.S. nationwide prospective cohort of female registered nurses. A UV exposure model was linked with geocoded residential address histories. Early-life UV exposure was estimated based on the state of residence at birth, age 15, and age 30. Self-reported breast cancer was confirmed from medical records. Time-varying Cox regression models adjusted for established breast cancer risk factors were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsFrom 1989 to 2013, 3,959 invasive breast cancer cases occurred among 112,447 participants. Higher UV exposure during adulthood was not associated with invasive breast cancer risk overall (adjusted HR comparing highest to lowest quintile = 1.00, 95% CI: 0.90, 1.11, p for trend = 0.64) or according to estrogen receptor (ER) status. There were suggestive inverse associations between ER- breast cancer and early-life UV exposure at birth (adjusted HR = 0.94, 95% CI: 0.88, 1.01 per interquartile range increase [15.7 mW/m2]), age 15 (adjusted HR = 0.96, 95% CI: 0.89, 1.04 per 18.0 mW/m2), and age 30 (adjusted HR = 0.90, 95% CI: 0.82, 1.00 per 27.7 mW/m2).ConclusionsAmbient UV exposure during adulthood was not associated with risk of invasive breast cancer overall or by ER status. However, we observed suggestive inverse associations between early-life UV exposure and ER- breast cancer risk.

Published
2019

153. Breast cancer risk after recent childbirth : A pooled analysis of 15 prospective studies

Author

Nichols, Hazel B., Schoemaker, Minouk J., Cai, Jianwen, Xu, Jiawei, Wright, Lauren B., Brook, Mark N., Jones, Michael E., Adami, Hans Olov, Baglietto, Laura, Bertrand, Kimberly A., Blot, William J., Boutron-Ruault, Marie Christine, Dorronsoro, Miren, Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Merritt, Melissa A., Milne, Roger L., Pala, Valeria, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Sund, Malin, Tamimi, Rulla M., Tjønneland, Anne, Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Zheng, Wei, Weinberg, Clarice R., Swerdlow, Anthony J., Sandler, Dale P., Nichols, Hazel B., Schoemaker, Minouk J., Cai, Jianwen, Xu, Jiawei, Wright, Lauren B., Brook, Mark N., Jones, Michael E., Adami, Hans Olov, Baglietto, Laura, Bertrand, Kimberly A., Blot, William J., Boutron-Ruault, Marie Christine, Dorronsoro, Miren, Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Merritt, Melissa A., Milne, Roger L., Pala, Valeria, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Sund, Malin, Tamimi, Rulla M., Tjønneland, Anne, Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Zheng, Wei, Weinberg, Clarice R., Swerdlow, Anthony J., and Sandler, Dale P.

Published
2019

154. Breast cancer risk after recent childbirth: A pooled analysis of 15 prospective studies

Author

UMC Utrecht Academie, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Nichols, Hazel B., Schoemaker, Minouk J., Cai, Jianwen, Xu, Jiawei, Wright, Lauren B., Brook, Mark N., Jones, Michael E., Adami, Hans Olov, Baglietto, Laura, Bertrand, Kimberly A., Blot, William J., Boutron-Ruault, Marie Christine, Dorronsoro, Miren, Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Merritt, Melissa A., Milne, Roger L., Pala, Valeria, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Sund, Malin, Tamimi, Rulla M., Tjønneland, Anne, Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Zheng, Wei, Weinberg, Clarice R., Swerdlow, Anthony J., Sandler, Dale P., UMC Utrecht Academie, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Nichols, Hazel B., Schoemaker, Minouk J., Cai, Jianwen, Xu, Jiawei, Wright, Lauren B., Brook, Mark N., Jones, Michael E., Adami, Hans Olov, Baglietto, Laura, Bertrand, Kimberly A., Blot, William J., Boutron-Ruault, Marie Christine, Dorronsoro, Miren, Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Merritt, Melissa A., Milne, Roger L., Pala, Valeria, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Sund, Malin, Tamimi, Rulla M., Tjønneland, Anne, Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Zheng, Wei, Weinberg, Clarice R., Swerdlow, Anthony J., and Sandler, Dale P.

Published
2019

155. Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women.

Author

Bertrand, Kimberly A, Bertrand, Kimberly A, Baer, Heather J, Orav, E John, Klifa, Catherine, Kumar, Ajay, Hylton, Nola M, LeBlanc, Erin S, Snetselaar, Linda G, Van Horn, Linda, Dorgan, Joanne F, Bertrand, Kimberly A, Bertrand, Kimberly A, Baer, Heather J, Orav, E John, Klifa, Catherine, Kumar, Ajay, Hylton, Nola M, LeBlanc, Erin S, Snetselaar, Linda G, Van Horn, Linda, and Dorgan, Joanne F

Abstract

BackgroundEmerging evidence suggests positive associations between serum anti-Müllerian hormone (AMH), a marker of ovarian function, and breast cancer risk. Body size at young ages may influence AMH levels, but few studies have examined this. Also, no studies have examined the relation of AMH levels with breast density, a strong predictor of breast cancer risk.MethodsWe examined associations of early life body fatness, AMH concentrations, and breast density among 172 women in the Dietary Intervention Study in Children (DISC). Height and weight were measured at baseline (ages 8-10) and throughout adolescence. Serum AMH concentrations and breast density were assessed at ages 25-29 at the DISC 2006 Follow-up visit. We used linear mixed effects models to quantify associations of AMH (dependent variable) with quartiles of age-specific youth body mass index (BMI) Z-scores (independent variable). We assessed cross-sectional associations of breast density (dependent variable) with AMH concentration (independent variable).ResultsNeither early life BMI nor current adult BMI was associated with AMH concentrations. There were no associations between AMH and percent or absolute dense breast volume. In contrast, women with higher AMH concentrations had significantly lower absolute nondense breast volume (Ptrend < 0.01).ConclusionsWe found no evidence that current or early life BMI influences AMH concentrations in later life. Women with higher concentrations of AMH had similar percent and absolute dense breast volume, but lower nondense volume.ImpactThese results suggest that AMH may be associated with lower absolute nondense breast volume; however, future prospective studies are needed to establish temporality. Cancer Epidemiol Biomarkers Prev; 25(7); 1151-7. ©2016 AACR.

Published
2016

161. Prepregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: A prospective cohort study

Author

BAO, Wei, SONG, Yiqing, BERTRAND, Kimberly A., TOBIAS, Deirdre K., OLSEN, Sjurdur F., CHAVARRO, Jorge E., MILLS, James L., HU, Frank B., and ZHANG, Cuilin

Subjects
Adult, Time Factors, Incidence, Age Factors, Nurses, Nutritional Status, Prenatal Care, Maternal Nutritional Physiological Phenomena, Recommended Dietary Allowances, Vitamin D Deficiency, Article, United States, Diet, Diabetes, Gestational, Young Adult, Pregnancy, Risk Factors, Dietary Supplements, Multivariate Analysis, Odds Ratio, Humans, Female, Prospective Studies, Vitamin D, Life Style
Abstract

BACKGROUND: Vitamin D may play a pivotal role in regulating insulin secretion and insulin sensitivity. However, the effect of vitamin D intake, either from the diet or from supplements, on the development of gestational diabetes mellitus (GDM) remains unclear. We prospectively examined the association of prepregnancy habitual intake of vitamin D from diet and supplements with the risk of incident GDM in a well-established cohort. METHODS: The present study was performed on 21 356 singleton pregnancies from 15 225 women in the Nurses’ Health Study II cohort. Diet information, including vitamin D intake from food sources and supplements, was assessed in 1991 and every 4 years thereafter by validated food frequency questionnaires. Log-binomial models with generalized estimating equations were used to estimate relative risks (RRs) and 95% confidence intervals (CIs). RESULTS: During 10 years of follow-up, 865 incident GDM cases were documented. After adjustment for age, parity, race/ethnicity, family history of diabetes, dietary and lifestyle factors, and body mass index, the RRs (95% CIs) of GDM risk associated with supplemental vitamin D intake of 0, 1–399, and ≥400 IU/day were 1.00 (reference), 0.80 (0.67–0.96), and 0.71 (0.56–0.90), respectively (P(trend) = 0.002). Dietary and total vitamin D intakes were also inversely associated with GDM risk, but the associations were not statistically significant. CONCLUSIONS: Prepregnancy supplemental vitamin D intake was significantly and inversely associated with risk of GDM. This study indicates potential benefits of increasing vitamin D intake from supplements in the prevention of GDM in women of reproductive age.

Published
2017

162. Breast Cancer Risk After Recent Childbirth

Author

Nichols, Hazel B., primary, Schoemaker, Minouk J., additional, Cai, Jianwen, additional, Xu, Jiawei, additional, Wright, Lauren B., additional, Brook, Mark N., additional, Jones, Michael E., additional, Adami, Hans-Olov, additional, Baglietto, Laura, additional, Bertrand, Kimberly A., additional, Blot, William J., additional, Boutron-Ruault, Marie-Christine, additional, Dorronsoro, Miren, additional, Dossus, Laure, additional, Eliassen, A. Heather, additional, Giles, Graham G., additional, Gram, Inger T., additional, Hankinson, Susan E., additional, Hoffman-Bolton, Judy, additional, Kaaks, Rudolf, additional, Key, Timothy J., additional, Kitahara, Cari M., additional, Larsson, Susanna C., additional, Linet, Martha, additional, Merritt, Melissa A., additional, Milne, Roger L., additional, Pala, Valeria, additional, Palmer, Julie R., additional, Peeters, Petra H., additional, Riboli, Elio, additional, Sund, Malin, additional, Tamimi, Rulla M., additional, Tjønneland, Anne, additional, Trichopoulou, Antonia, additional, Ursin, Giske, additional, Vatten, Lars, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Wolk, Alicja, additional, Zheng, Wei, additional, Weinberg, Clarice R., additional, Swerdlow, Anthony J., additional, and Sandler, Dale P., additional

Published
2018
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164. Association of mammographic density measures and breast cancer "intrinsic" molecular subtypes.

Author

Kleinstern, Geffen, Scott, Christopher G., Tamimi, Rulla M., Jensen, Matthew R., Pankratz, V. Shane, Bertrand, Kimberly A., Norman, Aaron D., Visscher, Daniel W., Couch, Fergus J., Brandt, Kathleen, Shepherd, John, Wu, Fang-Fang, Chen, Yunn-Yi, Cummings, Steven R., Winham, Stacey, Kerlikowske, Karla, and Vachon, Celine M.

Abstract

Purpose: We evaluated the association of percent mammographic density (PMD), absolute dense area (DA), and non-dense area (NDA) with risk of "intrinsic" molecular breast cancer (BC) subtypes. Methods: We pooled 3492 invasive BC and 10,148 controls across six studies with density measures from prediagnostic, digitized film-screen mammograms. We classified BC tumors into subtypes [63% Luminal A, 21% Luminal B, 5% HER2 expressing, and 11% as triple negative (TN)] using information on estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and tumor grade. We used polytomous logistic regression to calculate odds ratio (OR) and 95% confidence intervals (CI) for density measures (per SD) across the subtypes compared to controls, adjusting for age, body mass index and study, and examined differences by age group. Results: All density measures were similarly associated with BC risk across subtypes. Significant interaction of PMD by age (P = 0.001) was observed for Luminal A tumors, with stronger effect sizes seen for younger women < 45 years (OR = 1.69 per SD PMD) relative to women of older ages (OR = 1.53, ages 65–74, OR = 1.44 ages 75 +). Similar but opposite trends were seen for NDA by age for risk of Luminal A: risk for women: < 45 years (OR = 0.71 per SD NDA) was lower than older women (OR = 0.83 and OR = 0.84 for ages 65–74 and 75 + , respectively) (P < 0.001). Although not significant, similar patterns of associations were seen by age for TN cancers. Conclusions: Mammographic density measures were associated with risk of all "intrinsic" molecular subtypes. However, findings of significant interactions between age and density measures may have implications for subtype-specific risk models. [ABSTRACT FROM AUTHOR]

Published
2021
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166. Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women.

Author

Schoemaker, Minouk J, Nichols, Hazel B, Wright, Lauren B, Brook, Mark N, Jones, Michael E, O'Brien, Katie M, Adami, Hans-Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A, Boutron-Ruault, Marie-Christine, Braaten, Tonje, Chen, Yu, Connor, Avonne E, Dorronsoro, Miren, Dossus, Laure, Eliassen, A Heather, Giles, Graham G, Hankinson, Susan E, Kaaks, Rudolf, Key, Timothy J, Kirsh, Victoria A, Kitahara, Cari M, Koh, Woon-Puay, Larsson, Susanna C, Linet, Martha S, Ma, Huiyan, Masala, Giovanna, Merritt, Melissa A, Milne, Roger L, Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R, Peeters, Petra H, Riboli, Elio, Rohan, Thomas E, Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M, Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Sandler, Dale P, Swerdlow, Anthony J, Schoemaker, Minouk J, Nichols, Hazel B, Wright, Lauren B, Brook, Mark N, Jones, Michael E, O'Brien, Katie M, Adami, Hans-Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A, Boutron-Ruault, Marie-Christine, Braaten, Tonje, Chen, Yu, Connor, Avonne E, Dorronsoro, Miren, Dossus, Laure, Eliassen, A Heather, Giles, Graham G, Hankinson, Susan E, Kaaks, Rudolf, Key, Timothy J, Kirsh, Victoria A, Kitahara, Cari M, Koh, Woon-Puay, Larsson, Susanna C, Linet, Martha S, Ma, Huiyan, Masala, Giovanna, Merritt, Melissa A, Milne, Roger L, Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R, Peeters, Petra H, Riboli, Elio, Rohan, Thomas E, Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M, Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C, Wolk, Alicja, Yuan, Jian-Min, Zeleniuch-Jacquotte, Anne, Sandler, Dale P, and Swerdlow, Anthony J

Abstract

Importance: The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover effect exists, with risk reduction before and risk increase after menopause. The inverse association with premenopausal breast cancer risk is poorly characterized but might be important in the understanding of breast cancer causation. Objective: To investigate the association of BMI with premenopausal breast cancer risk, in particular by age at BMI, attained age, risk factors for breast cancer, and tumor characteristics. Design, Setting, and Participants: This multicenter analysis used pooled individual-level data from 758 592 premenopausal women from 19 prospective cohorts to estimate hazard ratios (HRs) of premenopausal breast cancer in association with BMI from ages 18 through 54 years using Cox proportional hazards regression analysis. Median follow-up was 9.3 years (interquartile range, 4.9-13.5 years) per participant, with 13 082 incident cases of breast cancer. Participants were recruited from January 1, 1963, through December 31, 2013, and data were analyzed from September 1, 2013, through December 31, 2017. Exposures: Body mass index at ages 18 to 24, 25 to 34, 35 to 44, and 45 to 54 years. Main Outcomes and Measures: Invasive or in situ premenopausal breast cancer. Results: Among the 758 592 premenopausal women (median age, 40.6 years; interquartile range, 35.2-45.5 years) included in the analysis, inverse linear associations of BMI with breast cancer risk were found that were stronger for BMI at ages 18 to 24 years (HR per 5 kg/m2 [5.0-U] difference, 0.77; 95% CI, 0.73-0.80) than for BMI at ages 45 to 54 years (HR per 5.0-U difference, 0.88; 95% CI, 0.86-0.91). The inverse associations were observed even among nonoverweight women. There was a 4.2-fold risk gradient between the highest and lowest BMI categories (BMI≥35.0 vs <17.0) at ages

Published
2018
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167. Exposure to hazardous air pollutants and risk of incident breast cancer in the nurses' health study II.

Author

Hart, Jaime E, Hart, Jaime E, Bertrand, Kimberly A, DuPre, Natalie, James, Peter, Vieira, Verónica M, VoPham, Trang, Mittleman, Maggie R, Tamimi, Rulla M, Laden, Francine, Hart, Jaime E, Hart, Jaime E, Bertrand, Kimberly A, DuPre, Natalie, James, Peter, Vieira, Verónica M, VoPham, Trang, Mittleman, Maggie R, Tamimi, Rulla M, and Laden, Francine

Abstract

BackgroundFindings from a recent prospective cohort study in California suggested increased risk of breast cancer associated with higher exposure to certain carcinogenic and estrogen-disrupting hazardous air pollutants (HAPs). However, to date, no nationwide studies have evaluated these possible associations. Our objective was to examine the impacts of mammary carcinogen and estrogen disrupting HAPs on risk of invasive breast cancer in a nationwide cohort.MethodsWe assigned HAPs from the US Environmental Protection Agency's 2002 National Air Toxics Assessment to 109,239 members of the nationwide, prospective Nurses' Health Study II (NHSII). Risk of overall invasive, estrogen receptor (ER)-positive (ER+), and ER-negative (ER-) breast cancer with increasing quartiles of exposure were assessed in time-varying multivariable proportional hazards models, adjusted for traditional breast cancer risk factors.ResultsA total of 3321 invasive cases occurred (2160 ER+, 558 ER-) during follow-up 1989-2011. Overall, there was no consistent pattern of elevated risk of the HAPs with risk of breast cancer. Suggestive elevations were only seen with increasing 1,2-dibromo-3-chloropropane exposures (multivariable adjusted HR of overall breast cancer = 1.12, 95% CI: 0.98-1.29; ER+ breast cancer HR = 1.09; 95% CI: 0.92, 1.30; ER- breast cancer HR = 1.14; 95% CI: 0.81, 1.61; each in the top exposure quartile compared to the lowest).ConclusionsExposures to HAPs during adulthood were not consistently associated with an increased risk of overall or estrogen-receptor subtypes of invasive breast cancer in this nationwide cohort of women.

Published
2018

168. Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk.

Author

Samraj, Annie N, Samraj, Annie N, Bertrand, Kimberly A, Luben, Robert, Khedri, Zahra, Yu, Hai, Nguyen, Dzung, Gregg, Christopher J, Diaz, Sandra L, Sawyer, Sherilyn, Chen, Xi, Eliassen, Heather, Padler-Karavani, Vered, Wu, Kana, Khaw, Kay-Tee, Willett, Walter, Varki, Ajit, Samraj, Annie N, Samraj, Annie N, Bertrand, Kimberly A, Luben, Robert, Khedri, Zahra, Yu, Hai, Nguyen, Dzung, Gregg, Christopher J, Diaz, Sandra L, Sawyer, Sherilyn, Chen, Xi, Eliassen, Heather, Padler-Karavani, Vered, Wu, Kana, Khaw, Kay-Tee, Willett, Walter, and Varki, Ajit

Abstract

BackgroundN-glycolylneuraminic acid (Neu5Gc) is a non-human red-meat-derived sialic acid immunogenic to humans. Neu5Gc can be metabolically incorporated into glycan chains on human endothelial and epithelial surfaces. This represents the first example of a "xeno-autoantigen", against which circulating human "xeno-autoantibodies" can react. The resulting inflammation ("xenosialitis") has been demonstrated in human-like Neu5Gc-deficient mice and contributed to carcinoma progression via antibody-mediated inflammation. Anti-Neu5Gc antibodies have potential as biomarkers for diseases associated with red meat consumption such as carcinomas, atherosclerosis, and type 2 diabetes.MethodsELISA assays measured antibodies against Neu5Gc or Neu5Gc-glycans in plasma or serum samples from the Nurses' Health Studies, the Health Professionals Follow-up Study, and the European Prospective Investigation into Cancer and Nutrition, including inter-assay reproducibility, stability with delayed sample processing, and within-person reproducibility over 1-3 years in archived samples. We also assessed associations between antibody levels and coronary artery disease risk (CAD) or red meat intake. A glycan microarray was used to detected antibodies against multiple Neu5Gc-glycan epitopes. A nested case-control study design assessed the association between total anti-Neu5Gc antibodies detected in the glycan array assay and the risk of colorectal cancer (CRC).ResultsELISA assays showed a wide range of anti-Neu5Gc responses and good inter-assay reproducibility, stability with delayed sample processing, and within-person reproducibility over time, but these antibody levels did not correlate with CAD risk or red meat intake. Antibodies against Neu5Gc alone or against individual Neu5Gc-bearing epitopes were also not associated with colorectal cancer (CRC) risk. However, a sialoglycan microarray study demonstrated positive association with CRC risk when the total antibody responses against all Neu5Gc

Published
2018

169. Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women

Author

Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie Christine, Braaten, Tonje, Chen, Yu, Connor, Avonne E., Dorronsoro, Miren, Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Koh, Woon Puay, Larsson, Susanna C., Linet, Martha S., Ma, Huiyan, Masala, Giovanna, Merritt, Melissa A., Milne, Roger L., Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Rohan, Thomas E., Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Yuan, Jian Min, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., Swerdlow, Anthony J., Premenopausal Breast Cancer Collaborative Group, Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie Christine, Braaten, Tonje, Chen, Yu, Connor, Avonne E., Dorronsoro, Miren, Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Koh, Woon Puay, Larsson, Susanna C., Linet, Martha S., Ma, Huiyan, Masala, Giovanna, Merritt, Melissa A., Milne, Roger L., Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Rohan, Thomas E., Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Yuan, Jian Min, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., Swerdlow, Anthony J., and Premenopausal Breast Cancer Collaborative Group

Published
2018

170. Does mammographic density mediate risk factor associations with breast cancer? An analysis by tumor characteristics.

Author

Rice, Megan, Rice, Megan, Tamimi, Rulla, Bertrand, Kimberly, Scott, Christopher, Jensen, Matthew, Norman, Aaron, Visscher, Daniel, Chen, Yunn-Yi, Brandt, Kathleen, Couch, Fergus, Shepherd, John, Wu, Fang-Fang, Ma, Lin, Collins, Laura, Cummings, Steven, Kerlikowske, Karla, Vachon, Celine, Fan, Bo, Rice, Megan, Rice, Megan, Tamimi, Rulla, Bertrand, Kimberly, Scott, Christopher, Jensen, Matthew, Norman, Aaron, Visscher, Daniel, Chen, Yunn-Yi, Brandt, Kathleen, Couch, Fergus, Shepherd, John, Wu, Fang-Fang, Ma, Lin, Collins, Laura, Cummings, Steven, Kerlikowske, Karla, Vachon, Celine, and Fan, Bo

Abstract

BACKGROUND: Though mammographic density (MD) has been proposed as an intermediate marker of breast cancer risk, few studies have examined whether the associations between breast cancer risk factors and risk are mediated by MD, particularly by tumor characteristics. METHODS: Our study population included 3392 cases (1105 premenopausal) and 8882 (3192 premenopausal) controls from four case-control studies. For established risk factors, we estimated the percent of the total risk factor association with breast cancer that was mediated by percent MD (secondarily, by dense area and non-dense area) for invasive breast cancer as well as for subtypes defined by the estrogen receptor (ER+/ER-), progesterone receptor (PR+/PR-), and HER2 (HER2+/HER2-). Analyses were conducted separately in pre- and postmenopausal women. RESULTS: Positive associations between prior breast biopsy and risk of invasive breast cancer as well as all subtypes were partially mediated by percent MD in pre- and postmenopausal women (percent mediated = 11-27%, p ≤ 0.02). In postmenopausal women, nulliparity and hormone therapy use were positively associated with invasive, ER+ , PR+ , and HER2- breast cancer; percent MD partially mediated these associations (percent mediated ≥ 31%, p ≤ 0.02). Further, among postmenopausal women, percent MD partially mediated the positive association between later age at first birth and invasive as well as ER+ breast cancer (percent mediated = 16%, p ≤ 0.05). CONCLUSION: Percent MD partially mediated the associations between breast biopsy, nulliparity, age at first birth, and hormone therapy with risk of breast cancer, particularly among postmenopausal women, suggesting that these risk factors at least partially influence breast cancer risk through changes in breast tissue composition.

Published
2018

171. Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women

Author

Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie Christine, Braaten, Tonje, Chen, Yu, Connor, Avonne E., Dorronsoro, Miren, Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Koh, Woon Puay, Larsson, Susanna C., Linet, Martha S., Ma, Huiyan, Masala, Giovanna, Merritt, Melissa A., Milne, Roger L., Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Rohan, Thomas E., Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Yuan, Jian Min, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., Swerdlow, Anthony J., Premenopausal Breast Cancer Collaborative Group, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie Christine, Braaten, Tonje, Chen, Yu, Connor, Avonne E., Dorronsoro, Miren, Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Koh, Woon Puay, Larsson, Susanna C., Linet, Martha S., Ma, Huiyan, Masala, Giovanna, Merritt, Melissa A., Milne, Roger L., Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Rohan, Thomas E., Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Yuan, Jian Min, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., Swerdlow, Anthony J., and Premenopausal Breast Cancer Collaborative Group

Published
2018

172. Dense and nondense mammographic area and risk of breast cancer by age and tumor characteristics.

Author

Bertrand, Kimberly A, Bertrand, Kimberly A, Scott, Christopher G, Tamimi, Rulla M, Jensen, Matthew R, Pankratz, V Shane, Norman, Aaron D, Visscher, Daniel W, Couch, Fergus J, Shepherd, John, Chen, Yunn-Yi, Fan, Bo, Wu, Fang-Fang, Ma, Lin, Beck, Andrew H, Cummings, Steven R, Kerlikowske, Karla, Vachon, Celine M, Bertrand, Kimberly A, Bertrand, Kimberly A, Scott, Christopher G, Tamimi, Rulla M, Jensen, Matthew R, Pankratz, V Shane, Norman, Aaron D, Visscher, Daniel W, Couch, Fergus J, Shepherd, John, Chen, Yunn-Yi, Fan, Bo, Wu, Fang-Fang, Ma, Lin, Beck, Andrew H, Cummings, Steven R, Kerlikowske, Karla, and Vachon, Celine M

Abstract

BackgroundMammographic density (MD) is a strong breast cancer risk factor. We previously reported associations of percent mammographic density (PMD) with larger and node-positive tumors across all ages, and estrogen receptor (ER)-negative status among women ages <55 years. To provide insight into these associations, we examined the components of PMD [dense area (DA) and nondense area (NDA)] with breast cancer subtypes.MethodsData were pooled from six studies including 4,095 breast cancers and 8,558 controls. DA and NDA were assessed from digitized film-screen mammograms and standardized across studies. Breast cancer odds by density phenotypes and age according to histopathologic characteristics and receptor status were calculated using polytomous logistic regression.ResultsDA was associated with increased breast cancer risk [OR for quartiles: 0.65, 1.00 (Ref), 1.22, 1.55; P(trend) <0.001] and NDA was associated with decreased risk [ORs for quartiles: 1.39, 1.00 (Ref), 0.88, 0.72; P(trend) <0.001] across all ages and invasive tumor characteristics. There were significant trends in the magnitude of associations of both DA and NDA with breast cancer by increasing tumor size (P(trend) < 0.001) but no differences by nodal status. Among women <55 years, DA was more strongly associated with increased risk of ER(+) versus ER(-) tumors (P(het) = 0.02), while NDA was more strongly associated with decreased risk of ER(-) versus ER(+) tumors (P(het) = 0.03).ConclusionsDA and NDA have differential associations with ER(+) versus ER(-) tumors that vary by age.ImpactDA and NDA are important to consider when developing age- and subtype-specific risk models.

Published
2015

173. Environmental radon exposure and breast cancer risk in the Nurses' Health Study II

Author

VoPham, Trang, DuPré, Natalie, Tamimi, Rulla M, James, Peter, Bertrand, Kimberly A, Vieira, Veronica, Laden, Francine, and Hart, Jaime E

Subjects
Adult, Ionizing radiation, Prevention, Incidence, Breast Neoplasms, Radiation Exposure, Toxicology, United States, Breast cancer, Radon, Risk Factors, Public Health and Health Services, Humans, Female, Prospective Studies, Cancer, Radioactive Pollutants
Abstract

BackgroundRadon and its decay products, a source of ionizing radiation, are primarily inhaled and can deliver a radiation dose to breast tissue, where they may continue to decay and emit DNA damage-inducing particles. Few studies have examined the relationship between radon and breast cancer.MethodsThe Nurses' Health Study II (NHSII) includes U.S. female registered nurses who completed biennial questionnaires since 1989. Self-reported breast cancer was confirmed from medical records. County-level radon exposures were linked with geocoded residential addresses updated throughout follow-up. Time-varying Cox regression models adjusted for established breast cancer risk factors were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsFrom 1989 to 2013, 3966 invasive breast cancer cases occurred among 112,639 participants. Increasing radon exposure was not associated with breast cancer risk overall (adjusted HR comparing highest to lowest quintile=1.06, 95% CI: 0.94, 1.21, p for trend=0.30). However, women in the highest quintile of exposure (≥74.9Bq/m3) had a suggested elevated risk of ER-/PR- breast cancer compared to women in the lowest quintile (

Published
2017

174. Risk factors for estrogen receptor positive ductal carcinoma in situ of the breast in African American women.

Author

Bertrand, Kimberly A., Bethea, Traci N., Rosenberg, Lynn, Bandera, Elisa V., Khoury, Thaer, Troester, Melissa A., Ambrosone, Christine B., and Palmer, Julie R.

Subjects
AFRICAN American women, CARCINOMA in situ, DUCTAL carcinoma, ESTROGEN receptors, BODY mass index, POSTMENOPAUSE
Abstract

Compared to U.S. white women, African American women are more likely to die from ductal carcinoma in situ (DCIS). Elucidation of risk factors for DCIS in African American women may provide opportunities for risk reduction. We used data from three epidemiologic studies in the African American Breast Cancer Epidemiology and Risk Consortium to study risk factors for estrogen receptor (ER) positive DCIS (488 cases; 13,830 controls). Results were compared to associations observed for ER+ invasive breast cancer (n = 2,099). First degree family history of breast cancer was associated with increased risk of ER+ DCIS [odds ratio (OR): 1.69, 95% confidence interval (CI): 1.31, 2.17]. Oral contraceptive use within the past 10 years (vs. never) was also associated with increased risk (OR: 1.43, 95%CI: 1.03, 1.97), as was late age at first birth (≥25 years vs. <20 years) (OR: 1.26, 95%CI: 0.96, 1.67). Risk was reduced in women with older age at menarche (≥15 years vs. <11 years) (OR: 0.62, 95%CI: 0.42, 0.93) and higher body mass index (BMI) in early adulthood (≥25 vs. <20 kg/m2 at age 18 or 21) (OR: 0.75, 95%CI: 0.55, 1.01). There was a positive association of recent BMI with risk in postmenopausal women only. In general, associations of risk factors for ER+ DCIS were similar in magnitude and direction to those for invasive ER+ breast cancer. Our findings suggest that most risk factors for invasive ER+ breast cancer are also associated with increased risk of ER+ DCIS among African American women. • Few studies of risk factors for ductal carcinoma in situ (DCIS) have evaluated associations for African American women. • We analyzed data from the African American African American Breast Cancer Epidemiology and Risk (AMBER) Consortium. • Family history of breast cancer, reproductive factors, and anthropometric factors were associated with risk of ER+ DCIS. • In general, risk factor associations for ER+ DCIS were similar to those for ER+ invasive breast cancer. • Our findings support a common etiology and pathogenesis between ER+ DICS and ER+ invasive cancer in African American women. [ABSTRACT FROM AUTHOR]

Published
2020
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178. A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non‐Hodgkin lymphoma

Author

Chiu, Yu‐Han, primary, Bertrand, Kimberly A., additional, Zhang, Shumin, additional, Laden, Francine, additional, Epstein, Mara M., additional, Rosner, Bernard A., additional, Chiuve, Stephanie, additional, Campos, Hannia, additional, Giovannucci, Edward L., additional, Chavarro, Jorge E., additional, and Birmann, Brenda M., additional

Published
2018
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182. Pre-diagnosis plasma immune markers and risk of non-Hodgkin lymphoma in two prospective cohort studies

Author

Epstein, Mara M., primary, Rosner, Bernard, additional, Breen, Elizabeth C., additional, Batista, Julie L., additional, Giovannucci, Edward L., additional, Magpantay, Larry, additional, Aster, Jon C., additional, Rodig, Scott J., additional, Bertrand, Kimberly A., additional, Laden, Francine, additional, Martínez-Maza, Otoniel, additional, and Birmann, Brenda M., additional

Published
2018
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183. Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk

Author

Samraj, Annie N., primary, Bertrand, Kimberly A., additional, Luben, Robert, additional, Khedri, Zahra, additional, Yu, Hai, additional, Nguyen, Dzung, additional, Gregg, Christopher J., additional, Diaz, Sandra L., additional, Sawyer, Sherilyn, additional, Chen, Xi, additional, Eliassen, Heather, additional, Padler-Karavani, Vered, additional, Wu, Kana, additional, Khaw, Kay-Tee, additional, Willett, Walter, additional, and Varki, Ajit, additional

Published
2018
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187. Does mammographic density mediate risk factor associations with breast cancer? An analysis by tumor characteristics

Author

Rice, Megan S., primary, Tamimi, Rulla M., additional, Bertrand, Kimberly A., additional, Scott, Christopher G., additional, Jensen, Matthew R., additional, Norman, Aaron D., additional, Visscher, Daniel W., additional, Chen, Yunn-Yi, additional, Brandt, Kathleen R., additional, Couch, Fergus J., additional, Shepherd, John A., additional, Fan, Bo, additional, Wu, Fang-Fang, additional, Ma, Lin, additional, Collins, Laura C., additional, Cummings, Steven R., additional, Kerlikowske, Karla, additional, and Vachon, Celine M., additional

Published
2018
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191. Benign and Malignant Outcomes in the Offspring of Females Exposed In Utero to Diethylstilbestrol (DES): An Update from the NCI Third Generation Study.

Author

Titus, Linda, Hatch, Elizabeth E., Bertrand, Kimberly A., Palmer, Julie R., Strohsnitter, William C., Huo, Dezheng, Curry, Michael, Hyer, Marianne, Aagaard, Kjersti, Gierach, Gretchen L., and Troisi, Rebecca

Subjects
*BREAST tumor risk factors, *ADENOCARCINOMA, *RISK assessment, *PRENATAL exposure delayed effects, *MATERNAL exposure, *CERVIX uteri diseases, *RESEARCH funding, *DESCRIPTIVE statistics, *DYSPLASIA, *CONFIDENCE intervals, *DATA analysis software, *DIETHYLSTILBESTROL, *TESTIS tumors, *PROPORTIONAL hazards models, *DISEASE risk factors, *FETUS
Abstract

Simple Summary: Females prenatally exposed to diethylstilbestrol have an elevated risk of severe cervical dysplasia and some cancers, while testicular cancer is increased in males. We assessed these associations in the prenatally exposed female's offspring (third generation). Based on third-generation females' self-reports, diethylstilbestrol exposure was not associated with risks of overall cancer, breast cancer, or severe cervical dysplasia. Borderline ovarian cancer risk in exposed vs. unexposed was elevated but compatible with chance. Based on mothers' reports, diethylstilbestrol exposure did not increase the risk of overall or other cancers in third-generation females. Overall cancer risk in exposed males appeared elevated but compatible with chance. Testicular cancer risk was not elevated in exposed males, and there were no prostate cancers reported. These data do not provide evidence that diethylstilbestrol is associated with cancer risk in third-generation females or males. The third generation is relatively young and requires follow-up to assess risk as the cohort ages. Background: Females exposed prenatally to diethylstilbestrol (DES) have an elevated risk of cervical dysplasia, breast cancer, and clear cell adenocarcinoma (CCA) of the cervix/vagina. Testicular cancer risk is increased in prenatally exposed males. Epigenetic changes may mediate the transmission of DES effects to the next ("third") generation of offspring. Methods: Using data self-reported by third-generation females, we assessed DES in relation to the risk of cancer and benign breast and reproductive tract conditions. Using data from prenatally DES-exposed and unexposed mothers, we assessed DES in relation to cancer risk in their female and male offspring. Cancer risk was assessed by standardized incidence ratios (SIR) and 95% confidence intervals (CI); the risks of benign and malignant diagnoses were assessed by hazard ratios (HR) and 95% CI. Results: In self-reported data, DES exposure was not associated with an increased risk of overall cancer (HR 0.83; CI 0.36–1.90), breast cancer, or severe cervical dysplasia. No females reported CCA. The risk of borderline ovarian cancer appeared elevated, but the HR was imprecise (3.46; CI 0.37–32.42). Based on mothers' reports, DES exposure did not increase the risk of overall cancer (HR 0.80; CI 0.49–1.32) or of other cancers in third-generation females. Overall cancer risk in exposed males appeared elevated (HR 1.41; CI 0.70–2.86), but the CI was wide. The risk of testicular cancer was not elevated in exposed males; no cases of prostate cancer were reported. Conclusions: To date, there is little evidence that DES is associated with cancer risk in third-generation females or males, but these individuals are relatively young, and further follow-up is needed. [ABSTRACT FROM AUTHOR]

Published
2024
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192. Hair relaxer use and risk of uterine cancer in the Black Women's Health Study.

Author

Bertrand, Kimberly A., Delp, Lauren, Coogan, Patricia F., Cozier, Yvette C., Lenzy, Yolanda M., Rosenberg, Lynn, and Palmer, Julie R.

Subjects
*UTERINE cancer, *POSTMENOPAUSE, *DISEASE risk factors, *WOMEN'S health, *BLACK women, *PROPORTIONAL hazards models
Abstract

Chemical hair relaxers, use of which is highly prevalent among Black women in the US, have been inconsistently linked to risk of estrogen-dependent cancers, such as breast cancer, and other reproductive health conditions. Whether hair relaxer use increases risk of uterine cancer is unknown. In the Black Women's Health Study, 44,798 women with an intact uterus who self-identified as Black were followed from 1997, when chemical hair relaxer use was queried, until 2019. Over follow-up, 347 incident uterine cancers were diagnosed. We used multivariable Cox proportional hazards regression models, adjusted for age and other potential confounders, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of hair relaxer use with risk of uterine cancer. Compared to women who never used hair relaxers or used them infrequently (<4 years and ≤1–2 times/year), the HR for uterine cancer associated with heavy use (≥15 years and at least 5 times/year) was 1.18 (95% CI: 0.81, 1.71). However, among postmenopausal women, compared to never/light use, the HR for moderate use was 1.60 (95% CI: 1.01, 2.53), the HR for heavy use was 1.64 (1.01, 2.64), and the HR for ≥20 years of use regardless of frequency was 1.71 (1.08, 2.72). Results among premenopausal women were null. In this large cohort of Black women, long-term use of chemical hair relaxers was associated with increased risk of uterine cancer among postmenopausal women, but not among premenopausal women. These findings suggest that hair relaxer use may be a potentially modifiable risk factor for uterine cancer. • Black women have higher uterine cancer mortality than non-Hispanic white women. • Use of chemical hair relaxers is common among Black women. • Long-term use of hair relaxers was associated with increased risk of uterine cancer among postmenopausal Black women. [ABSTRACT FROM AUTHOR]

Published
2023
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193. The Premenopausal Breast Cancer Collaboration : A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium.

Author

Nichols, Hazel B, Schoemaker, Minouk J, Wright, Lauren B, McGowan, Craig, Brook, Mark N, McClain, Kathleen M, Jones, Michael E, Adami, Hans-Olov, Agnoli, Claudia, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A, Blot, William J, Boutron-Ruault, Marie-Christine, Butler, Lesley, Chen, Yu, Doody, Michele M, Dossus, Laure, Eliassen, A Heather, Giles, Graham G, Gram, Inger T, Hankinson, Susan E, Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J, Kirsh, Victoria A, Kitahara, Cari M, Koh, Woon-Puay, Larsson, Susanna C, Lund, Eiliv, Ma, Huiyan, Merritt, Melissa A, Milne, Roger L, Navarro, Carmen, Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R, Peeters, Petra H, Riboli, Elio, Rohan, Thomas E, Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M, Trichopoulou, Antonia, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Sandler, Dale P, Swerdlow, Anthony J, Nichols, Hazel B, Schoemaker, Minouk J, Wright, Lauren B, McGowan, Craig, Brook, Mark N, McClain, Kathleen M, Jones, Michael E, Adami, Hans-Olov, Agnoli, Claudia, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A, Blot, William J, Boutron-Ruault, Marie-Christine, Butler, Lesley, Chen, Yu, Doody, Michele M, Dossus, Laure, Eliassen, A Heather, Giles, Graham G, Gram, Inger T, Hankinson, Susan E, Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J, Kirsh, Victoria A, Kitahara, Cari M, Koh, Woon-Puay, Larsson, Susanna C, Lund, Eiliv, Ma, Huiyan, Merritt, Melissa A, Milne, Roger L, Navarro, Carmen, Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R, Peeters, Petra H, Riboli, Elio, Rohan, Thomas E, Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M, Trichopoulou, Antonia, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Sandler, Dale P, and Swerdlow, Anthony J

Abstract

Breast cancer is a leading cancer diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, incidence rates of advanced breast cancer have increased in recent decades for premenopausal women. Progress in identifying contributors to breast cancer risk among premenopausal women has been constrained by the limited numbers of premenopausal breast cancer cases in individual studies and resulting low statistical power to subcategorize exposures or to study specific subtypes. The Premenopausal Breast Cancer Collaborative Group was established to facilitate cohort-based analyses of risk factors for premenopausal breast cancer by pooling individual-level data from studies participating in the United States National Cancer Institute Cohort Consortium. This article describes the Group, including the rationale for its initial aims related to pregnancy, obesity, and physical activity. We also describe the 20 cohort studies with data submitted to the Group by June 2016. The infrastructure developed for this work can be leveraged to support additional investigations. Cancer Epidemiol Biomarkers Prev; 26(9); 1360-9. ©2017 AACR.

Published
2017
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194. Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Author

Bernatsky, Sasha, Garcia, Hector A. Velasquez, Spinelli, John J., Gaffney, Patrick, Smedby, Karin E., Ramsey-Goldman, Rosalind, Wang, Sophia S., Adami, Hans-Olov, Albanes, Demetrius, Angelucci, Emanuele, Ansell, Stephen M., Asmann, Yan W., Becker, Nikolaus, Benavente, Yolanda, Berndt, Sonja I., Bertrand, Kimberly A., Birmann, Brenda M., Boeing, Heiner, Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brooks-Wilson, Angela R., Cerhan, James R., Chanock, Stephen J., Clavel, Jacqueline, Conde, Lucia, Cotenbader, Karen H., Cox, David G., Cozen, Wendy, Crouch, Simon, De Roos, Anneclaire J., de Sanjose, Silvia, Di Lollo, Simonetta, Diver, W. Ryan, Dogan, Ahmet, Foretova, Lenka, Ghesquieres, Herve, Giles, Graham G., Glimelius, Bengt, Habermann, Thomas M., Haioun, Corinne, Hartge, Patricia, Hjalgrim, Henrik, Holford, Theodore R., Holly, Elizabeth A., Jackson, Rebecca D., Kaaks, Rudolph, Kane, Eleanor, Kelly, Rachel S., Klein, Robert J., Kraft, Peter, Kricker, Anne, Lan, Qing, Lawrence, Charles, Liebow, Mark, Lightfoot, Tracy, Link, Brian K., Maynadie, Marc, Mckay, James, Melbye, Mads, Molina, Thierry J., Monnereau, Alain, Morton, Lindsay M., Nieters, Alexandra, North, Kari E., Novak, Anne J., Offit, Kenneth, Purdue, Mark P., Rais, Marco, Riby, Jacques, Roman, Eve, Rothman, Nathaniel, Salles, Gilles, Severi, Gianluca, Severson, Richard K., Skibola, Christine F., Slager, Susan L., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Staines, Anthony, Teras, Lauren R., Thompson, Carrie A., Tilly, Herve, Tinker, Lesley F., Tjonneland, Anne, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C. H., Vijai, Joseph, Vineis, Paolo, Virtamo, Jarmo, Wang, Zhaoming, Weinstein, Stephanie, Witzig, Thomas E., Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Zucca, Mariagrazia, Clarke, Ann E., Bernatsky, Sasha, Garcia, Hector A. Velasquez, Spinelli, John J., Gaffney, Patrick, Smedby, Karin E., Ramsey-Goldman, Rosalind, Wang, Sophia S., Adami, Hans-Olov, Albanes, Demetrius, Angelucci, Emanuele, Ansell, Stephen M., Asmann, Yan W., Becker, Nikolaus, Benavente, Yolanda, Berndt, Sonja I., Bertrand, Kimberly A., Birmann, Brenda M., Boeing, Heiner, Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brooks-Wilson, Angela R., Cerhan, James R., Chanock, Stephen J., Clavel, Jacqueline, Conde, Lucia, Cotenbader, Karen H., Cox, David G., Cozen, Wendy, Crouch, Simon, De Roos, Anneclaire J., de Sanjose, Silvia, Di Lollo, Simonetta, Diver, W. Ryan, Dogan, Ahmet, Foretova, Lenka, Ghesquieres, Herve, Giles, Graham G., Glimelius, Bengt, Habermann, Thomas M., Haioun, Corinne, Hartge, Patricia, Hjalgrim, Henrik, Holford, Theodore R., Holly, Elizabeth A., Jackson, Rebecca D., Kaaks, Rudolph, Kane, Eleanor, Kelly, Rachel S., Klein, Robert J., Kraft, Peter, Kricker, Anne, Lan, Qing, Lawrence, Charles, Liebow, Mark, Lightfoot, Tracy, Link, Brian K., Maynadie, Marc, Mckay, James, Melbye, Mads, Molina, Thierry J., Monnereau, Alain, Morton, Lindsay M., Nieters, Alexandra, North, Kari E., Novak, Anne J., Offit, Kenneth, Purdue, Mark P., Rais, Marco, Riby, Jacques, Roman, Eve, Rothman, Nathaniel, Salles, Gilles, Severi, Gianluca, Severson, Richard K., Skibola, Christine F., Slager, Susan L., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Staines, Anthony, Teras, Lauren R., Thompson, Carrie A., Tilly, Herve, Tinker, Lesley F., Tjonneland, Anne, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C. H., Vijai, Joseph, Vineis, Paolo, Virtamo, Jarmo, Wang, Zhaoming, Weinstein, Stephanie, Witzig, Thomas E., Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Zucca, Mariagrazia, and Clarke, Ann E.

Abstract

Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.

Published
2017
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195. The premenopausal breast cancer collaboration : A pooling project of studies participating in the national cancer institute cohort consortium

Author

Nichols, Hazel B., Schoemaker, Minouk J., Wright, Lauren B., McGowan, Craig, Brook, Mark N., Mcclain, Kathleen M., Jones, Michael E, Adami, Hans-Olov, Agnoli, Claudia, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A, Blot, William J., Boutron-Ruault, Marie Christine, Butler, Lesley M, Chen, Kuan-Yu, Doody, Michele M., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M, Koh, Woon-Puay, Larsson, Susanna C., Lund, Eiliv, Ma, Huiyan, Merritt, Melissa A., Milne, Roger L., Navarro, Carmen, Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Rohan, Thomas E., Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M, Trichopoulou, Antonia, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Sandler, Dale P, Swerdlow, Anthony J., Nichols, Hazel B., Schoemaker, Minouk J., Wright, Lauren B., McGowan, Craig, Brook, Mark N., Mcclain, Kathleen M., Jones, Michael E, Adami, Hans-Olov, Agnoli, Claudia, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A, Blot, William J., Boutron-Ruault, Marie Christine, Butler, Lesley M, Chen, Kuan-Yu, Doody, Michele M., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M, Koh, Woon-Puay, Larsson, Susanna C., Lund, Eiliv, Ma, Huiyan, Merritt, Melissa A., Milne, Roger L., Navarro, Carmen, Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Rohan, Thomas E., Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M, Trichopoulou, Antonia, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Sandler, Dale P, and Swerdlow, Anthony J.

Published
2017

196. Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Bernatsky, Sasha, Velásquez García, Héctor A, Spinelli, John, Gaffney, Patrick, Smedby, Karin E, Ramsey-Goldman, Rosalind, Wang, Sophia S., Adami, Hans-Olov, Albanes, Demetrius, Angelucci, Emanuele, Ansell, Stephen M., Asmann, Yan W., Becker, Nikolaus, Benavente, Yolanda, Berndt, Sonja I., Bertrand, Kimberly A., Birmann, Brenda M., Boeing, Heiner, Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brooks-Wilson, Angela R., Cerhan, James R., Chanock, Stephen J., Clavel, Jacqueline, Conde, Lucia, Cotenbader, Karen H, Cox, David G, Cozen, Wendy, Crouch, Simon, De Roos, Anneclaire J., De Sanjose, Silvia, Di Lollo, Simonetta, Diver, W. Ryan, Dogan, Ahmet, Foretova, Lenka, Ghesquières, Hervé, Giles, Graham G., Glimelius, Bengt, Habermann, Thomas M., Haioun, Corinne, Hartge, Patricia, Hjalgrim, Henrik, Holford, Theodore R., Holly, Elizabeth A., Jackson, Rebecca D., Kaaks, Rudolph, Kane, Eleanor, Kelly, Rachel S., Klein, Robert J., Kraft, Peter, Kricker, Anne, Lan, Qing, Lawrence, Charles, Liebow, Mark, Lightfoot, Tracy, Link, Brian K., Maynadie, Marc, McKay, James, Melbye, Mads, Molina, Thierry Jo, Monnereau, Alain, Morton, Lindsay M., Nieters, Alexandra, North, Kari E., Novak, Anne J., Offit, Kenneth, Purdue, Mark P., Rais, Marco, Riby, Jacques, Roman, Eve, Rothman, Nathaniel, Salles, Gilles, Severi, Gianluca, Severson, Richard K., Skibola, Christine F., Slager, Susan L., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Staines, Anthony, Teras, Lauren R., Thompson, Carrie A., Tilly, Hervé, Tinker, Lesley F., Tjonneland, Anne, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C H, Vijai, Joseph, Vineis, Paolo, Virtamo, Jarmo, Wang, Zhaoming, Weinstein, Stephanie, Witzig, Thomas E., Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Zucca, Mariagrazia, Clarke, Ann E, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Bernatsky, Sasha, Velásquez García, Héctor A, Spinelli, John, Gaffney, Patrick, Smedby, Karin E, Ramsey-Goldman, Rosalind, Wang, Sophia S., Adami, Hans-Olov, Albanes, Demetrius, Angelucci, Emanuele, Ansell, Stephen M., Asmann, Yan W., Becker, Nikolaus, Benavente, Yolanda, Berndt, Sonja I., Bertrand, Kimberly A., Birmann, Brenda M., Boeing, Heiner, Boffetta, Paolo, Bracci, Paige M., Brennan, Paul, Brooks-Wilson, Angela R., Cerhan, James R., Chanock, Stephen J., Clavel, Jacqueline, Conde, Lucia, Cotenbader, Karen H, Cox, David G, Cozen, Wendy, Crouch, Simon, De Roos, Anneclaire J., De Sanjose, Silvia, Di Lollo, Simonetta, Diver, W. Ryan, Dogan, Ahmet, Foretova, Lenka, Ghesquières, Hervé, Giles, Graham G., Glimelius, Bengt, Habermann, Thomas M., Haioun, Corinne, Hartge, Patricia, Hjalgrim, Henrik, Holford, Theodore R., Holly, Elizabeth A., Jackson, Rebecca D., Kaaks, Rudolph, Kane, Eleanor, Kelly, Rachel S., Klein, Robert J., Kraft, Peter, Kricker, Anne, Lan, Qing, Lawrence, Charles, Liebow, Mark, Lightfoot, Tracy, Link, Brian K., Maynadie, Marc, McKay, James, Melbye, Mads, Molina, Thierry Jo, Monnereau, Alain, Morton, Lindsay M., Nieters, Alexandra, North, Kari E., Novak, Anne J., Offit, Kenneth, Purdue, Mark P., Rais, Marco, Riby, Jacques, Roman, Eve, Rothman, Nathaniel, Salles, Gilles, Severi, Gianluca, Severson, Richard K., Skibola, Christine F., Slager, Susan L., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Staines, Anthony, Teras, Lauren R., Thompson, Carrie A., Tilly, Hervé, Tinker, Lesley F., Tjonneland, Anne, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C H, Vijai, Joseph, Vineis, Paolo, Virtamo, Jarmo, Wang, Zhaoming, Weinstein, Stephanie, Witzig, Thomas E., Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Yawei, Zheng, Tongzhang, Zucca, Mariagrazia, and Clarke, Ann E

Published
2017

197. Interaction of mammographic breast density with menopausal status and postmenopausal hormone use in relation to the risk of aggressive breast cancer subtypes.

Author

Chen, Yunn-Yi, Chen, Yunn-Yi, Ma, Lin, Beck, Andrew, Cummings, Steven, Kerlikowske, Karla, Vachon, Celine, Yaghjyan, Lusine, Tamimi, Rulla, Bertrand, Kimberly, Scott, Christopher, Jensen, Matthew, Pankratz, V, Brandt, Kathy, Visscher, Daniel, Norman, Aaron, Couch, Fergus, Shepherd, John, Fan, Bo, Chen, Yunn-Yi, Chen, Yunn-Yi, Ma, Lin, Beck, Andrew, Cummings, Steven, Kerlikowske, Karla, Vachon, Celine, Yaghjyan, Lusine, Tamimi, Rulla, Bertrand, Kimberly, Scott, Christopher, Jensen, Matthew, Pankratz, V, Brandt, Kathy, Visscher, Daniel, Norman, Aaron, Couch, Fergus, Shepherd, John, and Fan, Bo

Abstract

PURPOSE: We examined the associations of mammographic breast density with breast cancer risk by tumor aggressiveness and by menopausal status and current postmenopausal hormone therapy. METHODS: This study included 2596 invasive breast cancer cases and 4059 controls selected from participants of four nested case-control studies within four established cohorts: the Mayo Mammography Health Study, the Nurses Health Study, Nurses Health Study II, and San Francisco Mammography Registry. Percent breast density (PD), absolute dense (DA), and non-dense areas (NDA) were assessed from digitized film-screen mammograms using a computer-assisted threshold technique and standardized across studies. We used polytomous logistic regression to quantify the associations of breast density with breast cancer risk by tumor aggressiveness (defined as presence of at least two of the following tumor characteristics: size ≥2 cm, grade 2/3, ER-negative status, or positive nodes), stratified by menopausal status and current hormone therapy. RESULTS: Overall, the positive association of PD and borderline inverse association of NDA with breast cancer risk was stronger in aggressive vs. non-aggressive tumors (≥51 vs. 11-25% OR 2.50, 95% CI 1.94-3.22 vs. OR 2.03, 95% CI 1.70-2.43, p-heterogeneity = 0.03; NDA 4th vs. 2nd quartile OR 0.54, 95% CI 0.41-0.70 vs. OR 0.71, 95% CI 0.59-0.85, p-heterogeneity = 0.07). However, there were no differences in the association of DA with breast cancer by aggressive status. In the stratified analysis, there was also evidence of a stronger association of PD and NDA with aggressive tumors among postmenopausal women and, in particular, current estrogen+progesterone users (≥51 vs. 11-25% OR 3.24, 95% CI 1.75-6.00 vs. OR 1.93, 95% CI 1.25-2.98, p-heterogeneity = 0.01; NDA 4th vs. 2nd quartile OR 0.43, 95% CI 0.21-0.85 vs. OR 0.56, 95% CI 0.35-0.89, p-heterogeneity = 0.01), even though the interaction was not significan

Published
2017

198. The premenopausal breast cancer collaboration: A pooling project of studies participating in the national cancer institute cohort consortium

Author

UMC Utrecht, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Nichols, Hazel B., Schoemaker, Minouk J., Wright, Lauren B., McGowan, Craig, Brook, Mark N., Mcclain, Kathleen M., Jones, Michael E, Adami, Hans-Olov, Agnoli, Claudia, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A, Blot, William J., Boutron-Ruault, Marie Christine, Butler, Lesley M, Chen, Kuan-Yu, Doody, Michele M., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M, Koh, Woon-Puay, Larsson, Susanna C., Lund, Eiliv, Ma, Huiyan, Merritt, Melissa A., Milne, Roger L., Navarro, Carmen, Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Rohan, Thomas E., Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M, Trichopoulou, Antonia, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Sandler, Dale P, Swerdlow, Anthony J., UMC Utrecht, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Nichols, Hazel B., Schoemaker, Minouk J., Wright, Lauren B., McGowan, Craig, Brook, Mark N., Mcclain, Kathleen M., Jones, Michael E, Adami, Hans-Olov, Agnoli, Claudia, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A, Blot, William J., Boutron-Ruault, Marie Christine, Butler, Lesley M, Chen, Kuan-Yu, Doody, Michele M., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M, Koh, Woon-Puay, Larsson, Susanna C., Lund, Eiliv, Ma, Huiyan, Merritt, Melissa A., Milne, Roger L., Navarro, Carmen, Overvad, Kim, Ozasa, Kotaro, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Rohan, Thomas E., Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M, Trichopoulou, Antonia, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Sandler, Dale P, and Swerdlow, Anthony J.

Published
2017

199. Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide

Author

Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Burton, Anya, Maskarinec, Gertraud, Perez-Gomez, Beatriz, Vachon, Celine, Miao, Hui, Lajous, Martín, López-Ridaura, Ruy, Rice, Megan, Pereira, Ana, Garmendia, Maria Luisa, Tamimi, Rulla M, Bertrand, Kimberly A, Kwong, Ava, Ursin, Giske, Lee, Eunjung, Qureshi, Samera A, Ma, Huiyan, Vinnicombe, Sarah, Moss, Sue, Allen, Steve, Ndumia, Rose, Vinayak, Sudhir, Teo, Soo Hwang, Mariapun, Shivaani, Fadzli, Farhana, Peplonska, Beata, Bukowska, Agnieszka, Nagata, Chisato, Stone, Jennifer, Hopper, John L., Giles, Graham G., Ozmen, Vahit, Aribal, Mustafa Erkin, Schüz, Joachim, Van Gils, Carla H, Wanders, Johanna Olga Pauline, Sirous, Reza, Sirous, Mehri, Hipwell, John H, Kim, Jisun, Lee, Jong Won, Dickens, Caroline, Hartman, Mikael, Chia, Kee Seng, Scott, Christopher, Chiarelli, Anna M, Linton, Linda, Pollan, Marina, Flugelman, Anath Arzee, Salem, Dorria, Kamal, Rasha, Boyd, Norman F, Dos-Santos-Silva, Isabel, McCormack, Valerie, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Burton, Anya, Maskarinec, Gertraud, Perez-Gomez, Beatriz, Vachon, Celine, Miao, Hui, Lajous, Martín, López-Ridaura, Ruy, Rice, Megan, Pereira, Ana, Garmendia, Maria Luisa, Tamimi, Rulla M, Bertrand, Kimberly A, Kwong, Ava, Ursin, Giske, Lee, Eunjung, Qureshi, Samera A, Ma, Huiyan, Vinnicombe, Sarah, Moss, Sue, Allen, Steve, Ndumia, Rose, Vinayak, Sudhir, Teo, Soo Hwang, Mariapun, Shivaani, Fadzli, Farhana, Peplonska, Beata, Bukowska, Agnieszka, Nagata, Chisato, Stone, Jennifer, Hopper, John L., Giles, Graham G., Ozmen, Vahit, Aribal, Mustafa Erkin, Schüz, Joachim, Van Gils, Carla H, Wanders, Johanna Olga Pauline, Sirous, Reza, Sirous, Mehri, Hipwell, John H, Kim, Jisun, Lee, Jong Won, Dickens, Caroline, Hartman, Mikael, Chia, Kee Seng, Scott, Christopher, Chiarelli, Anna M, Linton, Linda, Pollan, Marina, Flugelman, Anath Arzee, Salem, Dorria, Kamal, Rasha, Boyd, Norman F, Dos-Santos-Silva, Isabel, and McCormack, Valerie

Published
2017

200. Additional file 1: Table S1. of Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status

Author

Malkov, Serghei, Shepherd, John, Scott, Christopher, Rulla Tamimi, Ma, Lin, Bertrand, Kimberly, Couch, Fergus, Jensen, Matthew, Mahmoudzadeh, Amir, Fan, Bo, Norman, Aaron, Brandt, Kathleen, V. Pankratz, Celine Vachon, and Kerlikowske, Karla

Abstract

Baseline characteristics of study population per study site. Table S2. Pearson correlation coefficient for top 15 significant features. Correlations calculated using case subjects. Gray and gray with line pattern highlight strength of positive and negative associations, respectively. (PDF 123 kb)

Published
2016
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