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Your search keyword '"Bengoechea, Jose A."' showing total 175 results
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175 results on '"Bengoechea, Jose A."'

155. Pore-forming Proteins of Genus Yersinia

Author

Vostrikova, Olga P., Novikova, Olga D., Kim, Natalya Y., Likhatskaya, Galina N., Solovjeva, Tamara F., Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Skurnik, Mikael, editor, Bengoechea, José Antonio, editor, and Granfors, Kaisa, editor

Published
2003
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159. Acute and Chronic Experimental Infection Processes Caused by Yersinia pseudotuberculosis and Evaluation of Interleukin Action on Their Development and Outcome

Author

Tseneva, Galina Y., Voskressenskaya, Ekaterina A., Simbirtsev, Andrey S., Shestakova, Irina V., Demakova, Tatiana E., Chmyr, Irina A., Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Skurnik, Mikael, editor, Bengoechea, José Antonio, editor, and Granfors, Kaisa, editor

Published
2003
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161. Yersinia pseudotuberculosis, Its Toxins and Plant Cells

Author

Timchenko, Nelly, Eliseikina, Marina, Bulgakov, Viktor, Bulakh, Elena, Yasnetskaya, Elena, Nedashkovskaya, Elena, Zhuravlev, Yury, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Skurnik, Mikael, editor, Bengoechea, José Antonio, editor, and Granfors, Kaisa, editor

Published
2003
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163. Mechanisms of Yersinia enterocolitica Evasion of the Host Innate Immune Response by V Antigen

Author

Sing, Andreas, Rost, Dagmar, Tvardovskaia, Natalia, Roggenkamp, Andreas, Geiger, Anna M., Kirschning, Carsten J., Wiedemann, Agnès, Aepfelbacher, Martin, Heesemann, Jürgen, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Skurnik, Mikael, editor, Bengoechea, José Antonio, editor, and Granfors, Kaisa, editor

Published
2003
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168. The Fish Pathogen Yersinia ruckeri Possesses a TTS System

Author

Gunasena, Deephti K., Komrower, Jenny R., Macintyre, Sheila, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Skurnik, Mikael, editor, Bengoechea, José Antonio, editor, and Granfors, Kaisa, editor

Published
2003
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169. Identification of Genes Involved in Yersinia pestis Virulence by Signature-tagged Mutagenesis

Author

Flashner, Yehuda, Mamroud, Emanuelle, Tidhar, Avital, Ber, Raphael, Aftalion, Moshe, Gur, David, Zvi, Anat, Ariel, Naomi, Velan, Baruch, Shafferman, Avigdor, Cohen, Sara, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Skurnik, Mikael, editor, Bengoechea, José Antonio, editor, and Granfors, Kaisa, editor

Published
2003
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171. ID: 103: Innate immune sensing of nucleic acids in airway epithelial cells compared to monocytic cells.

Author

Massa, Davide, Przybyszewska, Kora, Bengoechea, Jose A., and Bowie, Andrew G.

Subjects
*ACIDOLYSIS, *NUCLEIC acids, *CYTOKINES, *TYPE I interferons, *GENOMES
Abstract

In the last decade mechanisms for innate immune sensing of pathogen and self nucleic acids have been defined. For cytosolic sensing of DNA, the adaptor protein STING has a central role, operating downstream of DNA sensors such as cGAS and IFI16 to mediate transcription factor activation and cytokine and interferon induction. However most of the work in defining cytosolic DNA sensing pathways has been done in monocytic cells, while sensing mechanisms in other frontline sensing cells such as airway epithelial cells have been less well defined. Thus here we analysed the innate immune response of human airway epithelial cell line models to RNA and DNA, in comparison to a human monocytic cell line. Our results show that in both monocytic and epithelial cells the innate immune response to RNA virus and dsRNA was promptly activated. However compared to monocytic cells, A549 and BEAS-2B epithelial cells failed to produce inflammatory cytokines and interferons in response to DNA viruses and dsDNA. These cells lacked expression of IFI16 or STING, but did express cGAS. Ectopic expression of STING restored the DNA response in A549 cells, in a cGAS-dependent manner. In contrast to A549 and BEAS-2B cells, the hTERT-immortalised normal airway epithelial cell line NuLi-1 did express IFI16, cGAS and STING, and responded to DNA viruses and DNA in a STING-dependent manner. These results highlight the loss of DNA responses in epithelial cell lines lacking STING, and have relevance in considering different cell models for innate sensing studies in airway epithelial cells. [ABSTRACT FROM AUTHOR]

Published
2015
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173. Vaccination with Plasmid DNA Expressing the Yersinia pestis Capsular Protein F1 Protects Mice Against Plague

Author

Grosfeld, Haim, Bino, Tamar, Flashner, Yehuda, Ber, Raphael, Mamroud, Emanuelle, Lustig, Shlomo, Velan, Baruch, Shafferman, Avigdor, Cohen, Sara, Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Skurnik, Mikael, editor, Bengoechea, José Antonio, editor, and Granfors, Kaisa, editor

Published
2003
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175. Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent.

Author

Storey D, McNally A, Åstrand M, Sa-Pessoa Graca Santos J, Rodriguez-Escudero I, Elmore B, Palacios L, Marshall H, Hobley L, Molina M, Cid VJ, Salminen TA, and Bengoechea JA

Subjects
Bacterial Proteins genetics, Escherichia coli genetics, Escherichia coli physiology, Gene Expression Regulation, Bacterial, Klebsiella pneumoniae genetics, Type VI Secretion Systems genetics, Bacterial Proteins metabolism, Klebsiella pneumoniae metabolism, Reactive Oxygen Species metabolism, Type VI Secretion Systems metabolism
Abstract

Klebsiella pneumoniae is recognized as an urgent threat to human health due to the increasing isolation of multidrug resistant strains. Hypervirulent strains are a major concern due to their ability to cause life-threating infections in healthy hosts. The type VI secretion system (T6SS) is widely implicated in microbial antagonism, and it mediates interactions with host eukaryotic cells in some cases. In silico search for genes orthologous to T6SS component genes and T6SS effector genes across 700 K. pneumoniae genomes shows extensive diversity in T6SS genes across the K. pneumoniae species. Temperature, oxygen tension, pH, osmolarity, iron levels, and NaCl regulate the expression of the T6SS encoded by a hypervirulent K. pneumoniae strain. Polymyxins and human defensin 3 also increase the activity of the T6SS. A screen for regulators governing T6SS uncover the correlation between the transcription of the T6SS and the ability to kill E. coli prey. Whereas H-NS represses the T6SS, PhoPQ, PmrAB, Hfq, Fur, RpoS and RpoN positively regulate the T6SS. K. pneumoniae T6SS mediates intra and inter species bacterial competition. This antagonism is only evident when the prey possesses an active T6SS. The PhoPQ two component system governs the activation of K. pneumoniae T6SS in bacterial competitions. Mechanistically, PhoQ periplasmic domain, and the acid patch within, is essential to activate K. pneumoniae T6SS. Klebsiella T6SS also mediates anti-fungal competition. We have delineated the contribution of each of the individual VgrGs in microbial competition and identified VgrG4 as a T6SS effector. The DUF2345 domain of VgrG4 is sufficient to intoxicate bacteria and yeast. ROS generation mediates the antibacterial effects of VgrG4, and the antitoxin Sel1E protects against the toxic activity of VgrG4. Our findings provide a better understanding of the regulation of the T6SS in bacterial competitions, and place ROS as an early event in microbial competition., Competing Interests: The authors have declared that no competing interests exist

Published
2020
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