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151. 985: COMPARISON OF ONE-YEAR OUTCOMES BETWEEN ADALIMUMAB AND INFLIXIMAB IN CHILDREN WITH LUMINAL CROHN'S DISEASE: A MULTICENTER PROSPECTIVE COHORT STUDY

Author

deBruyn, Jennifer C., primary, Huynh, Hien Q., additional, Griffiths, Anne M., additional, Jacobson, Kevan, additional, Mack, David R., additional, Deslandres, Colette, additional, El-Matary, Wael, additional, Otley, Anthony, additional, Lawrence, Sally, additional, Wine, Eytan, additional, Sherlock, Mary, additional, Critch, Jeffrey, additional, Jantchou, Prevost, additional, Rashid, Mohsin, additional, Carroll, Matthew, additional, Bax, Kevin, additional, Seidman, Ernest G., additional, Benchimol, Eric I., additional, Ricciuto, Amanda, additional, Church, Peter, additional, and Walters, Thomas D., additional

Published
2022
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153. Twenty-first Century Trends in the Global Epidemiology of Pediatric-Onset Inflammatory Bowel Disease: Systematic Review

Author

Kuenzig, M. Ellen, primary, Fung, Stephen G., additional, Marderfeld, Luba, additional, Mak, Joyce W.Y., additional, Kaplan, Gilaad G., additional, Ng, Siew C., additional, Wilson, David C., additional, Cameron, Fiona, additional, Henderson, Paul, additional, Kotze, Paulo G., additional, Bhatti, Jasmine, additional, Fang, Vixey, additional, Gerber, Samantha, additional, Guay, Evelyne, additional, Kotteduwa Jayawarden, Supun, additional, Kadota, Leo, additional, Maldonado D., Fernando, additional, Osei, Jessica Amankwah, additional, Sandarage, Ryan, additional, Stanton, Amanda, additional, Wan, Melissa, additional, Benchimol, Eric I., additional, Jayawarden, Supun K., additional, Maldonado, Fernando, additional, Maltus, Emma, additional, Bhattacharya, Shoumak, additional, and Osei, Jessica, additional

Published
2022
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154. Additional file 1 of Real world evidence of the association between medication and life expectancy in elderly inflammatory bowel disease: a population-based cohort study

Author

Kuenzig, M. Ellen, Manuel, Douglas G., Donelle, Jessy, and Benchimol, Eric I.

Abstract

Additional file 1. Table S1. List of drug identification numbers used to identify medications included in this study. Table S2. List of validated codes used to identify patients requiring small bowel resection (Crohn���s disease) or colectomy (Crohn���s disease and ulcerative colitis). Table S3. Differences in life expectancy at 65 years comparing medications used to treat Crohn���s disease in seniors. Differences correspond to the medication referenced in the column name subtracted from the medication reference in the row name (i.e., LErow ��� LEcolumn). Significant differences are indicated in bold font. Table S4. Differences in life expectancy at 65 years comparing medications used to treat ulcerative colitis in seniors. Differences correspond to the medication referenced in the column name subtracted from the medication reference in the row name (i.e., LErow ��� LEcolumn). Significant differences are indicated in bold font. Table S5. Differences in life expectancy at 65 years comparing medications used to treat Crohn���s disease in seniors, censoring at intestinal resection or colectomy. Differences correspond to the medication referenced in the column name subtracted from the medication reference in the row name (i.e., LErow ��� LEcolumn). Significant differences are indicated in bold font. Table S6. Differences in life expectancy at 65 years comparing medications used to treat ulcerative colitis in seniors, censoring at colectomy. Differences correspond to the medication referenced in the column name subtracted from the medication reference in the row name (i.e., LErow ��� LEcolumn). Significant differences are indicated in bold font. Figure S1. Life expectancy at 65 years of age in (A) females and (B) males with Crohn���s disease, stratified by type of medical treatment. Figure S2. The proportion of people expected to be alive at each age interval based on type of medical treatment in (A) females and (B) males with Crohn���s disease. Figure S3. Life expectancy at 65 years of age in (A) females and (B) males with ulcerative colitis, stratified by type of medical treatment. Figure S4. The proportion of people expected to be alive at each age interval based on type of medical treatment in (A) females and (B) males with ulcerative colitis.Figure S5. Life expectancy at 65 years of age in (A) females and (B) males with Crohn���s disease, stratified by type of medical treatment and censored at intestinal resection or surgery. Figure S6. Life expectancy at 65 years of age in (A) females and (B) males with ulcerative colitis, stratified by type of medical treatment and censored at colectomy. Figure S7. The proportion of people expected to be alive at each age interval based on type of medical treatment in (A) females and (B) males with Crohn���s disease, censored at intestinal resection or colectomy. Figure S8. The proportion of people expected to be alive at each age interval based on type of medical treatment in (A) females and (B) males with ulcerative colitis, censoring at colectomy.

Published
2022
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155. Additional file 1 of Multimodal intervention to improve the transition of patients with inflammatory bowel disease from pediatric to adult care: protocol for a randomized controlled trial

Author

Bollegala, Natasha, Barwick, Melanie, Fu, Nancy, Griffiths, Anne M., Keefer, Laurie, Kohut, Sara Ahola, Kroeker, Karen I., Lawrence, Sally, Lee, Kate, Mack, David R., Walters, Thomas D., de Guzman, Jacqueline, Tersigni, Claudia, Miatello, Ashleigh, and Benchimol, Eric I.

Abstract

Additional file 1. Supplemental Table 1. Measures for Implementation Outcomes.

Published
2022
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161. Mo2047 FECAL CALPROTECTIN LEVEL DOES NOT CORRELATE WITH DISEASE LOCATION AT DIAGNOSIS IN PEDIATRIC INFLAMMATORY BOWEL DISEASE

Author

Sherlock, Mary, Zachos, Mary, Belaghi, Reza, Chavannes, Mallory, deBruyn, Jennifer C., Griffiths, Anne M., Benchimol, Eric I., Jacobson, Kevan, El-Matary, Wael, Mack, David R., Walters, Thomas D., Deslandres, Colette, Critch, Jeffrey, Crowley, Eileen, Ricciuto, Amanda, Jantchou, Prévost, Schneider, Rilla E., Wine, Eytan, Huynh, Hien Q., Carroll, Matthew, Lawrence, Sally, and Hart, Lara

Published
2024
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162. Mo1886 VALIDATION OF THE USE OF ARTIFICIAL INTELLIGENCE FOR CLASSIFICATION OF ULCERATIVE COLITIS VS CROHN'S DISEASE IN PEDIATRIC PATIENTS

Author

Hart, Lara, Sherlock, Mary, Belaghi, Reza, Barrowman, Nick, Crowley, Eileen, Jacobson, Kevan, Lawrence, Sally, Huynh, Hien Q., Carroll, Matthew, Wine, Eytan, deBruyn, Jennifer C., El-Matary, Wael, Griffiths, Anne M., Walters, Thomas D., Benchimol, Eric I., Ricciuto, Amanda, Mack, David R., Deslandres, Colette, Schneider, Rilla, Otley, Anthony, Critch, Jeffrey, Jantchou, Prévost, and Zachos, Mary

Published
2024
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163. Mo1887 ASSESSING DISEASE SEVERITY IN PEDIATRIC IBD PATIENTS USING FECAL CALPROTECTIN AND MACHINE LEARNING

Author

Zachos, Mary, Hart, Lara, Belaghi, Reza, Barrowman, Nick, Benchimol, Eric I., Carroll, Matthew, Crowley, Eileen, deBruyn, Jennifer C., Deslandres, Colette, El-Matary, Wael, Griffiths, Anne M., Jacobson, Kevan, Huynh, Hien Q., Lawrence, Sally, Ricciuto, Amanda, Walters, Thomas D., Wine, Eytan, Jantchou, Prévost, Otley, Anthony, Critch, Jeffrey, Mack, David R., and Sherlock, Mary

Published
2024
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165. 1091 ASSOCIATION OF AIR POLLUTION WITH RISK OF CROHN'S DISEASE AND BIOMARKERS OF CD RISK IN THE CCC-GEM PROJECT

Author

Shao, Jingcheng, Xue, Mingyue, Neustaeter, Anna, Lee, Sun-Ho, Panaccione, Remo, Huynh, Hien Q., Griffiths, Anne M., Steinhart, A. Hillary, Otley, Anthony, Aumais, Guy L., Moayyedi, Paul, Jacobson, Kevan, Mack, David R., Olivera, Pablo A., Leibovitzh, Haim, Motsinger-Reif, Alison, Benchimol, Eric I., Turpin, Williams, and Croitoru, Kenneth

Published
2024
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166. Canadian Consensus Statements on the Transition of Adolescents and Young Adults with Inflammatory Bowel Disease from Pediatric to Adult Care: A Collaborative Initiative Between the Canadian IBD Transition Network and Crohn’s and Colitis Canada

Author

Fu, Nancy, primary, Bollegala, Natasha, additional, Jacobson, Kevan, additional, Kroeker, Karen I, additional, Frost, Karen, additional, Afif, Waqqas, additional, El-Matary, Wael, additional, Fowler, Sharyle A, additional, Griffiths, Anne M, additional, Huynh, Hien Q, additional, Jantchou, Prévost, additional, Karimuddin, Ahmer, additional, Nguyen, Geoffrey C, additional, Otley, Anthony R, additional, Pears, Christina, additional, Seow, Cynthia H, additional, Toulany, Alene, additional, Tersigni, Claudia, additional, Tignanelli, Joanne, additional, Marshall, John K, additional, Boctor, Monica, additional, Hansen, Tawnya, additional, Pattni, Chandni, additional, Wong, Andrew, additional, and Benchimol, Eric I, additional

Published
2022
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167. Serological Responses to the First Three Doses of SARS-CoV-2 Vaccination in Inflammatory Bowel Disease: A Prospective Cohort Study

Author

Quan, Joshua, primary, Ma, Christopher, additional, Panaccione, Remo, additional, Hracs, Lindsay, additional, Sharifi, Nastaran, additional, Herauf, Michelle, additional, Markovinović, Ante, additional, Coward, Stephanie, additional, Windsor, Joseph W., additional, Caplan, Léa, additional, Ingram, Richard J. M., additional, Kanji, Jamil N., additional, Tipples, Graham, additional, Holodinsky, Jessalyn K., additional, Bernstein, Charles N., additional, Mahoney, Douglas J., additional, Bernatsky, Sasha, additional, Benchimol, Eric I., additional, and Kaplan, Gilaad G., additional

Published
2022
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169. EPIDEMIOLOGY OF INFLAMMATORY BOWEL DISEASE AMONG EARLY-INDUSTRIALIZED REGIONS OF THE WORLD: CHALLENGES IN SUSTAINABLE HEALTHCARE DELIVERY

Author

Herauf, Michelle, Coward, Stephanie, Pena-Sanchez, Juan Nicolas, Bernstein, Charles, Benchimol, Eric, Bitton, Alain, Forbes, Angela, Rowan, Catherine, Lees, Charlie, Seow, Cynthia, Turner, Dan, Brunet-Mas, Eduard, Loftus, Edward, Singh, Harminder, St-Pierre, Joelle, Burisch, Johan, Windsor, Joseph, Ernest-Suarez, Kenneth, Targownik, Laura, Hracs, Lindsay, Martin, Meaghan, Lakatos, Peter, Panaccione, Remo, Gearry, Richard, Murthy, Sanjay, Ng, Siew, El-Matary, Wael, and Kaplan, Gilaad

Published
2024
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170. TRENDS IN INFLAMMATORY BOWEL DISEASE INCIDENCE AND PREVALENCE ACROSS EPIDEMIOLOGIC STAGES: A GLOBAL SYSTEMATIC REVIEW WITH META-ANALYSIS

Author

Gorospe, Julia, Windsor, Joseph, Hracs, Lindsay, Coward, Stephanie, Buie, Michael, Quan, Joshua, Caplan, Lea, Markovinovic, Ante, Cummings, Michael, Goddard, Quinn, Williamson, Tyler, Abbey, Yvonne, Abreu, Maria, Ali, Raja, Abdullah, Murdani, Altuwaijri, Mansour, Ahuja, Vineet, Balderramo, Domingo, Banerjee, Rupa, Benchimol, Eric, Bernstein, Charles, Brunet-Mas, Eduard, Burisch, Johan, Chong, Vui Heng, Dotan, Iris, Dutta, Usha, El Ouali, Sara, Forbes, Angela, Forss, Anders, Gearry, Richard, Dao, Viet Hang, Hartono, Juanda, Hilmi, Ida, Julian-Banos, Fabian, Kaibullayeva, Jamilya, Kelly, Paul, Kotze, Paulo, Lakatos, Peter, Lees, Charlie, Limsrivilai, Julajak, Loftus, Edward, Ludvigsson, Jonas, Mak, Joyce, Ng, Ka Kei, Olen, Ola, Panaccione, Remo, Paudel, Mukesh, Quaresma, Abel, Rubin, David, Simadibrata, Marcellus, Sun, Yang, Suzuki, Hidekazu, Toro, Martin, Turner, Dan, Vergara, Beatriz Iade, Wei, Shu-Chen, Yamamoto-Furusho, Jesus, Yang, Kuk-Kyun, Ng, Siew, and Kaplan, Gilaad

Published
2024
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172. MODELING THE TRANSITION TO THE FOURTH EPIDEMIOLOGIC STAGE OF INFLAMMATORY BOWEL DISEASE: PREVALENCE EQUILIBRIUM

Author

Windsor, Joseph, Hracs, Lindsay, Cummings, Michael, Gorospe, Julia, Buie, Michael, Quan, Joshua, Markovinovic, Ante, Caplan, Lea, Goddard, Quinn, Williamson, Tyler, Abbey, Yvonne, Abreu, Maria, Ali, Raja, Abdullah, Murdani, Altuwaijri, Mansour, Ahuja, Vineet, Balderramo, Domingo, Banerjee, Rupa, Benchimol, Eric, Bernstein, Charles, Brunet-Mas, Eduard, Burisch, Johan, Dotan, Iris, Dutta, Usha, El Ouali, Sara, Forbes, Angela, Gearry, Richard, Dao, Viet Hang, Hartono, Juanda, Hilmi, Ida, Julian-Banos, Fabian, Kaibullayeva, Jamilya, Kelly, Paul, Kotze, Paulo, Lakatos, Peter, Lees, Charlie, Limsrivilai, Julajak, Loftus, Edward, Ludvigsson, Jonas, Mak, Joyce, Ng, Ka Kei, Olen, Ola, Panaccione, Remo, Paudel, Mukesh, Quaresma, Abel, Rubin, David, Simadibrata, Marcellus, Sun, Yang, Suzuki, Hidekazu, Toro, Martin, Turner, Dan, Vergara, Beatriz Iade, Wei, Shu-Chen, Yamamoto-Furusho, Jesus, Yang, Kuk-Kyun, Ng, Siew, Coward, Stephanie, and Kaplan, Gilaad

Published
2024
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173. MACHINE LEARNING CLASSIFICATION OF THE EPIDEMIOLOGIC STAGES OF INFLAMMATORY BOWEL DISEASE ACROSS GEOGRAPHY AND TIME

Author

Hracs, Lindsay, Windsor, Joseph, Gorospe, Julia, Buie, Michael, Quan, Joshua, Caplan, Lea, Markovinovic, Ante, Cummings, Michael, Goddard, Quinn, Williamson, Tyler, Abbey, Yvonne, Abreu, Maria, Ali, Raja, Abdullah, Murdani, Altuwaijri, Mansour, Ahuja, Vineet, Balderramo, Domingo, Banerjee, Rupa, Benchimol, Eric, Bernstein, Charles, Brunet-Mas, Eduard, Burisch, Johan, Chong, Vui Heng, Dotan, Iris, Dutta, Usha, El Ouali, Sara, Forbes, Angela, Forss, Anders, Gearry, Richard, Dao, Viet Hang, Hartono, Juanda, Hilmi, Ida, Julian-Banos, Fabian, Kaibullayeva, Jamilya, Kelly, Paul, Kotze, Paulo, Lakatos, Peter, Lees, Charlie, Limsrivilai, Julajak, Loftus, Edward, Ludvigsson, Jonas, Mak, Joyce, Ng, Ka Kei, Olen, Ola, Panaccione, Remo, Paudel, Mukesh, Quaresma, Abel, Rubin, David, Simadibrata, Marcellus, Sun, Yang, Suzuki, Hidekazu, Toro, Martin, Turner, Dan, Vergara, Beatriz Iade, Wei, Shu-Chen, Yamamoto-Furusho, Jesus, Yang, Kuk-Kyun, Ng, Siew, Coward, Stephanie, and Kaplan, Gilaad

Published
2024
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174. EXPLORING FACTORS ASSOCIATED WITH SEROLOGICAL RESPONSE TO SARS-COV-2 VACCINES IN INDIVIDUALS WITH INFLAMMATORY BOWEL DISEASE: INTERACTIVE VISUALIZATION METHODS FOR MULTIDIMENSIONAL DATA

Author

Hracs, Lindsay, Quan, Joshua, Ma, Christopher, Panaccione, Remo, Sharifi, Nastaran, Herauf, Michelle, Markovinovic, Ante, Coward, Stephanie, Windsor, Joseph, Caplan, Lea, Gorospe, Julia, Ernest-Suarez, Kenneth, Ingram, Richard, Holodinsky, Jessalyn, Bernstein, Charles, Mahoney, Douglas, Bernatsky, Sasha, Benchimol, Eric, and Kaplan, Gilaad

Published
2024
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175. Impact of antegrade enema initiation on healthcare utilization in pediatric patients: A population‐based cohort study.

Author

Gould, Michelle J., Marcon, Margaret A., Nguyen, Geoffrey C., Benchimol, Eric I., Moineddin, Rahim, Swayze, Sarah, Kopp, Alexander, Ratcliffe, Elyanne M., Merritt, Neil, Davidson, Jacob, Langer, Jacob C., Mistry, Niraj, Lorenzo, Armando J., Temple, Michael, and Walsh, Catharine M.

Subjects
ENEMA, CHILD patients, GENERALIZED estimating equations, COHORT analysis, MEDICAL care
Abstract

Background: When constipation is refractory to first‐line interventions, antegrade enema use may be considered. We aimed to assess the impact of this intervention on healthcare utilization. Methods: We conducted a population‐based, quasi‐experimental study with pre–post comparison of the intervention group and a non‐equivalent control group using linked clinical and health administrative data from Ontario, Canada. Subjects included children (0–18 years) who underwent antegrade enema initiation from 2007 to 2020 and matched controls (4:1) from the general population. To assess the change in healthcare utilization following antegrade enema initiation, we used negative binomial generalized estimating equations with covariates selected a priori. Key Results: One hundred thirty‐eight subjects met eligibility criteria (appendicostomy = 55 (39.9%); cecostomy tube = 83 (60.1%)) and were matched to 550 controls. There was no significant difference in the change in the rate of hospitalizations (rate ratio (RR) 1.05, 95% confidence interval (CI) 0.35–1.75), outpatient visits (RR 1.05, 95% CI 0.91–1.18), or same‐day surgical procedures (RR 1.51, 95% CI 0.60–2.43) across cases in 2 years following antegrade enema initiation compared with controls. Cases had an increased rate of emergency department (ED) visits, which was not observed in controls (RR 1.52, 95% CI 1.11–1.79), driven in part by device‐related complications. Conclusions and Inferences: Understanding healthcare utilization patterns following antegrade enema initiation allows for effective health system planning and aids medical decision‐making. The observed increase in ED visits for device‐related complications speaks to the need to improve preventive management to help mitigate emergency care after initiation of antegrade enemas. [ABSTRACT FROM AUTHOR]

Published
2023
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176. HARmonized Protocol Template to Enhance Reproducibility of hypothesis evaluating real‐world evidence studies on treatment effects: A good practices report of a joint ISPE/ISPOR task force.

Author

Wang, Shirley V., Pottegård, Anton, Crown, William, Arlett, Peter, Ashcroft, Darren M., Benchimol, Eric I., Berger, Marc L., Crane, Gracy, Goettsch, Wim, Hua, Wei, Kabadi, Shaum, Kern, David M., Kurz, Xavier, Langan, Sinead, Nonaka, Takahiro, Orsini, Lucinda, Perez‐Gutthann, Susana, Pinheiro, Simone, Pratt, Nicole, and Schneeweiss, Sebastian

Abstract

Problem: Ambiguity in communication of key study parameters limits the utility of real‐world evidence (RWE) studies in healthcare decision‐making. Clear communication about data provenance, design, analysis, and implementation is needed. This would facilitate reproducibility, replication in independent data, and assessment of potential sources of bias. What We Did: The International Society for Pharmacoepidemiology (ISPE) and ISPOR–The Professional Society for Health Economics and Outcomes Research (ISPOR) convened a joint task force, including representation from key international stakeholders, to create a harmonized protocol template for RWE studies that evaluate a treatment effect and are intended to inform decision‐making. The template builds on existing efforts to improve transparency and incorporates recent insights regarding the level of detail needed to enable RWE study reproducibility. The overarching principle was to reach for sufficient clarity regarding data, design, analysis, and implementation to achieve 3 main goals. One, to help investigators thoroughly consider, then document their choices and rationale for key study parameters that define the causal question (e.g., target estimand), two, to facilitate decision‐making by enabling reviewers to readily assess potential for biases related to these choices, and three, to facilitate reproducibility. Strategies to Disseminate and Facilitate Use: Recognizing that the impact of this harmonized template relies on uptake, we have outlined a plan to introduce and pilot the template with key international stakeholders over the next 2 years. Conclusion: The HARmonized Protocol Template to Enhance Reproducibility (HARPER) helps to create a shared understanding of intended scientific decisions through a common text, tabular and visual structure. The template provides a set of core recommendations for clear and reproducible RWE study protocols and is intended to be used as a backbone throughout the research process from developing a valid study protocol, to registration, through implementation and reporting on those implementation decisions. [ABSTRACT FROM AUTHOR]

Published
2023
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179. Crohn’s and Colitis Canada’s 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: Children and Expectant Mothers With Inflammatory Bowel Disease

Author

Benchimol, Eric I, primary, Carroll, Matthew W, additional, Geist, Rose, additional, Griffiths, Anne M, additional, Huang, James Guoxian, additional, Mack, David R, additional, Bernstein, Charles N, additional, Bitton, Alain, additional, Jones, Jennifer L, additional, Kaplan, Gilaad G, additional, Kuenzig, M Ellen, additional, Lee, Kate, additional, Mukhtar, Mariam S, additional, Murthy, Sanjay K, additional, Tandon, Parul, additional, Targownik, Laura E, additional, Windsor, Joseph W, additional, and Seow, Cynthia H, additional

Published
2021
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180. Crohn’s and Colitis Canada’s 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: Mental Health and Quality of Life

Author

Graff, Lesley A, primary, Fowler, Sharyle, additional, Jones, Jennifer L, additional, Benchimol, Eric I, additional, Bitton, Alain, additional, Huang, James Guoxian, additional, Kuenzig, M Ellen, additional, Kaplan, Gilaad G, additional, Lee, Kate, additional, Mukhtar, Mariam S, additional, Tandon, Parul, additional, Targownik, Laura E, additional, Windsor, Joseph W, additional, and Bernstein, Charles N, additional

Published
2021
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181. Crohn’s and Colitis Canada’s 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: COVID-19 Vaccines—Biology, Current Evidence and Recommendations

Author

Murthy, Sanjay K, primary, Kuenzig, M Ellen, additional, Windsor, Joseph W, additional, Ghia, Jean-Eric, additional, Griffiths, Anne M, additional, Panaccione, Remo, additional, Seow, Cynthia H, additional, Benchimol, Eric I, additional, Bernstein, Charles N, additional, Bitton, Alain, additional, Huang, James Guoxian, additional, Jones, Jennifer L, additional, Lee, Kate, additional, Kaplan, Gilaad G, additional, Mukhtar, Mariam S, additional, Tandon, Parul, additional, Targownik, Laura E, additional, and Gibson, Deanna L, additional

Published
2021
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182. Crohn’s and Colitis Canada’s 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: Executive Summary

Author

Ellen Kuenzig, M, primary, Windsor, Joseph W, additional, Barrett, Lisa, additional, Bernstein, Charles N, additional, Bitton, Alain, additional, Carroll, Matthew W, additional, Chauhan, Usha, additional, Coward, Stephanie, additional, Fowler, Sharyle, additional, Ghia, Jean-Eric, additional, Geist, Rose, additional, Gibson, Deanna L, additional, Graff, Lesley A, additional, Griffiths, Anne M, additional, Guoxian Huang, James, additional, Jones, Jennifer L, additional, Khanna, Reena, additional, Lakatos, Peter L, additional, Lee, Kate, additional, Mack, David R, additional, Marshall, John K, additional, Mukhtar, Mariam S, additional, Murthy, Sanjay K, additional, Nguyen, Geoffrey C, additional, Panaccione, Remo, additional, Seow, Cynthia H, additional, Singh, Harminder, additional, Tandon, Parul, additional, Targownik, Laura E, additional, Zelinsky, Sandra, additional, Benchimol, Eric I, additional, and Kaplan, Gilaad G, additional

Published
2021
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183. Crohn’s and Colitis Canada’s 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: Epidemiology—The Trends of Disease Over Time

Author

Coward, Stephanie, primary, Windsor, Joseph W, additional, Kuenzig, M Ellen, additional, Bitton, Alain, additional, Bernstein, Charles N, additional, Jones, Jennifer L, additional, Khanna, Reena, additional, Lee, Kate, additional, Murthy, Sanjay K, additional, Targownik, Laura, additional, Benchimol, Eric, additional, Huang, James Guoxian, additional, Mukhtar, Mariam S, additional, Tandon, Parul, additional, and Kaplan, Gilaad G, additional

Published
2021
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184. Crohn’s and Colitis Canada’s 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: Risk Factors and Medications

Author

Targownik, Laura E, primary, Bernstein, Charles N, additional, Lakatos, Peter L, additional, Murthy, Sanjay K, additional, Benchimol, Eric I, additional, Bitton, Alain, additional, Huang, James Guoxian, additional, Kuenzig, M Ellen, additional, Jones, Jennifer L, additional, Kaplan, Gilaad G, additional, Lee, Kate, additional, Mukhtar, Mariam S, additional, Tandon, Parul, additional, Windsor, Joseph W, additional, and Panaccione, Remo, additional

Published
2021
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185. Crohn’s and Colitis Canada’s 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: Seniors With IBD

Author

Bernstein, Charles N, primary, Singh, Harminder, additional, Murthy, Sanjay K, additional, Nguyen, Geoffrey C, additional, Benchimol, Eric I, additional, Bitton, Alain, additional, Kuenzig, M Ellen, additional, Huang, James Guoxian, additional, Jones, Jennifer L, additional, Lee, Kate, additional, Targownik, Laura E, additional, Windsor, Joseph W, additional, Mukhtar, Mariam S, additional, Tandon, Parul, additional, and Kaplan, Gilaad G, additional

Published
2021
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186. Crohn’s and Colitis Canada’s 2021 Impact of COVID-19 & Inflammatory Bowel Disease in Canada: A Knowledge Translation Strategy

Author

Kaplan, Gilaad G, primary, Windsor, Joseph W, additional, Crain, Janet, additional, Barrett, Lisa, additional, Bernstein, Charles N, additional, Bitton, Alain, additional, Chauhan, Usha, additional, Coward, Stephanie, additional, Fowler, Sharyle, additional, Ghia, Jean-Eric, additional, Gibson, Deanna L, additional, Griffiths, Anne M, additional, Jones, Jennifer L, additional, Khanna, Reena, additional, Kuenzig, M Ellen, additional, Lakatos, Peter L, additional, Lee, Kate, additional, Mack, David R, additional, Marshall, John K, additional, Mawani, Mina, additional, Murthy, Sanjay K, additional, Panaccione, Remo, additional, Seow, Cynthia H, additional, Targownik, Laura E, additional, Zelinsky, Sandra, additional, and Benchimol, Eric I, additional

Published
2021
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188. Crohn’s and Colitis Canada’s 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: Health Care Delivery During the Pandemic and the Future Model of Inflammatory Bowel Disease Care

Author

Jones, Jennifer L, primary, Benchimol, Eric I, additional, Bernstein, Charles N, additional, Huang, James Guoxian, additional, Marshall, John K, additional, Mukhtar, Mariam S, additional, Murthy, Sanjay K, additional, Nguyen, Geoffrey C, additional, Kaplan, Gilaad G, additional, Kuenzig, M Ellen, additional, Tandon, Parul, additional, Targownik, Laura E, additional, Windsor, Joseph W, additional, and Bitton, Alain, additional

Published
2021
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189. CONSORT extension for the reporting of randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE): checklist with explanation and elaboration

Author

Kwakkenbos, Linda, Imran, Mahrukh, McCall, Stephen J., McCord, Kimberly A., Hemkens, Lars G., Zwarenstein, Merrick, Relton, Clare, Rice, Danielle B., Benchimol, Eric I., Thabane, Lehana, Campbell, Marion K., Sampson, Margaret, Erlinge, David, Verkooijen, Helena M., Moher, David, Boutron, Isabelle, Ravaud, Philippe, Nicholl, Jon, Uher, Rudolf, Fletcher, John, Torgerson, David, Gale, Chris, Juszczak, Edmund, Thombs, Brett D., and Juszczak, Edmund

Abstract

Randomised controlled trials are increasingly conducted as embedded, nested, or using cohorts or routinely collected data, including registries, electronic health records, and administrative databases, to assess if participants are eligible for the trial and to facilitate recruitment, to deliver an embedded intervention, to collect trial outcome data, or a combination of these purposes. This report presents the Consolidated Standards of Reporting Trials (CONSORT) extension for randomised controlled trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE). The extension was developed to look at the unique characteristics of trials conducted with these types of data with the goal of improving reporting quality in the long term by setting standards early in the process of uptake of these trial designs. The extension was developed with a sequential approach, including a Delphi survey, a consensus meeting, and piloting of the checklist. The checklist was informed by the CONSORT 2010 statement and two reporting guidelines for observational studies, the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement and the REporting of studies Conducted using Observational Routinely collected Data (RECORD) statement. The extension includes eight items modified from the CONSORT 2010 statement and five new items. Reporting items with explanations and examples are provided, including key aspects of trials conducted using cohorts or routinely collected data that require specific reporting considerations.

Published
2021

190. Methods and results used in the development of a consensus-driven extension to the Consolidated Standards of Reporting Trials (CONSORT) statement for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE)

Author

Imran, Mahrukh, Kwakkenbos, Linda, McCall, Stephen J, McCord, Kimberly A, Hemkens, Lars G, Zwarenstein, Merrick, Relton, Clare, Rice, Danielle B, Benchimol, Eric I, Thabane, Lehana, Campbell, Marion K, Sampson, Margaret, Erlinge, David, Verkooijen, Helena M, Moher, David, Boutron, Isabelle, Ravaud, Philippe, Nicholl, Jon, Uher, Rudolf, Fletcher, John, Torgerson, David, Gale, Chris, Juszczak, Edmund, and Thombs, Brett D

Subjects
General Medicine
Abstract

Objectives Randomised controlled trials conducted using cohorts and routinely collected data, including registries, electronic health records and administrative databases, are increasingly used in healthcare intervention research. A Consolidated Standards of Reporting Trials (CONSORT) statement extension for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE) has been developed with the goal of improving reporting quality. This article describes the processes and methods used to develop the extension and decisions made to arrive at the final checklist.Methods The development process involved five stages: (1) identification of the need for a reporting guideline and project launch; (2) conduct of a scoping review to identify possible modifications to CONSORT 2010 checklist items and possible new extension items; (3) a three-round modified Delphi study involving key stakeholders to gather feedback on the checklist; (4) a consensus meeting to finalise items to be included in the extension, followed by stakeholder piloting of the checklist; and (5) publication, dissemination and implementation of the final checklist.Results 27 items were initially developed and rated in Delphi round 1, 13 items were rated in round 2 and 11 items were rated in round 3. Response rates for the Delphi study were 92 of 125 (74%) invited participants in round 1, 77 of 92 (84%) round 1 completers in round 2 and 62 of 77 (81%) round 2 completers in round 3. Twenty-seven members of the project team representing a variety of stakeholder groups attended the in-person consensus meeting. The final checklist includes five new items and eight modified items. The extension Explanation & Elaboration document further clarifies aspects that are important to report.ConclusionUptake of CONSORT-ROUTINE and accompanying Explanation & Elaboration document will improve conduct of trials, as well as the transparency and completeness of reporting of trials conducted using cohorts and routinely collected data.

Published
2021

191. Additional file 1 of Multivariable models for advanced colorectal neoplasms in screen-eligible individuals at low-to-moderate risk of colorectal cancer: towards improving colonoscopy prioritization

Author

Murthy, Sanjay K., Antonova, Lilia, Dube, Catherine, Benchimol, Eric I., Le Gal, Gregoire, Hae, Richard, Burke, Stephen, Ramsay, Tim, and Rostom, Alaa

Abstract

Additional file 1. Table S1. Ontario Health Administrative Databases and variable ascertainment codes for candidate predictors ascertained through administrative data.

Published
2021
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192. Additional file 3 of Multivariable models for advanced colorectal neoplasms in screen-eligible individuals at low-to-moderate risk of colorectal cancer: towards improving colonoscopy prioritization

Author

Murthy, Sanjay K., Antonova, Lilia, Dube, Catherine, Benchimol, Eric I., Le Gal, Gregoire, Hae, Richard, Burke, Stephen, Ramsay, Tim, and Rostom, Alaa

Abstract

Additional file 3. Table S3. Model performance at different sensitivity thresholds for CRC and HRA detection among patients with major CRC risk factors (sequential models for CRC and residual ACNs).

Published
2021
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193. Additional file 6 of Multivariable models for advanced colorectal neoplasms in screen-eligible individuals at low-to-moderate risk of colorectal cancer: towards improving colonoscopy prioritization

Author

Murthy, Sanjay K., Antonova, Lilia, Dube, Catherine, Benchimol, Eric I., Le Gal, Gregoire, Hae, Richard, Burke, Stephen, Ramsay, Tim, and Rostom, Alaa

Abstract

Additional file 6. Table S6. Model performance at different sensitivity thresholds for CRC detection among patients aged 50–74 (CRC model only).

Published
2021
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194. Additional file 7 of Multivariable models for advanced colorectal neoplasms in screen-eligible individuals at low-to-moderate risk of colorectal cancer: towards improving colonoscopy prioritization

Author

Murthy, Sanjay K., Antonova, Lilia, Dube, Catherine, Benchimol, Eric I., Le Gal, Gregoire, Hae, Richard, Burke, Stephen, Ramsay, Tim, and Rostom, Alaa

Abstract

Additional file 7. Table S7. Model performance at different sensitivity thresholds for CRC and HRA detection among patients aged 50–74 (sequential models for CRC and residual ACNs).

Published
2021
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195. Additional file 8 of Multivariable models for advanced colorectal neoplasms in screen-eligible individuals at low-to-moderate risk of colorectal cancer: towards improving colonoscopy prioritization

Author

Murthy, Sanjay K., Antonova, Lilia, Dube, Catherine, Benchimol, Eric I., Le Gal, Gregoire, Hae, Richard, Burke, Stephen, Ramsay, Tim, and Rostom, Alaa

Subjects
neoplasms, digestive system diseases
Abstract

Additional file 8. Table S8. Model performance at different sensitivity thresholds for CRC detection among patients aged 75 and older (CRC model only).

Published
2021
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196. Additional file 2 of Multivariable models for advanced colorectal neoplasms in screen-eligible individuals at low-to-moderate risk of colorectal cancer: towards improving colonoscopy prioritization

Author

Murthy, Sanjay K., Antonova, Lilia, Dube, Catherine, Benchimol, Eric I., Le Gal, Gregoire, Hae, Richard, Burke, Stephen, Ramsay, Tim, and Rostom, Alaa

Subjects
neoplasms, digestive system diseases
Abstract

Additional file 2. Table S2. Model performance at different sensitivity thresholds for CRC detection among patients with major CRC risk factors (CRC model only).

Published
2021
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197. Additional file 4 of Multivariable models for advanced colorectal neoplasms in screen-eligible individuals at low-to-moderate risk of colorectal cancer: towards improving colonoscopy prioritization

Author

Murthy, Sanjay K., Antonova, Lilia, Dube, Catherine, Benchimol, Eric I., Le Gal, Gregoire, Hae, Richard, Burke, Stephen, Ramsay, Tim, and Rostom, Alaa

Subjects
neoplasms, digestive system diseases
Abstract

Additional file 4. Table S4. Model performance at different sensitivity thresholds for CRC detection among patients with signs or symptoms (CRC model only).

Published
2021
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198. Additional file 9 of Multivariable models for advanced colorectal neoplasms in screen-eligible individuals at low-to-moderate risk of colorectal cancer: towards improving colonoscopy prioritization

Author

Murthy, Sanjay K., Antonova, Lilia, Dube, Catherine, Benchimol, Eric I., Le Gal, Gregoire, Hae, Richard, Burke, Stephen, Ramsay, Tim, and Rostom, Alaa

Abstract

Additional file 9. Table S9. Model performance at different sensitivity thresholds for CRC and HRA detection among patients aged 75 and older (sequential models for CRC and residual ACNs).

Published
2021
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199. Inflammatory Bowel Disease Clinical Activity is Associated with COVID-19 Severity Especially in Younger Patients

Author

Ricciuto, Amanda, primary, Lamb, Christopher A, additional, Benchimol, Eric I, additional, Walker, Gareth J, additional, Kennedy, Nicholas A, additional, Kuenzig, M Ellen, additional, Kaplan, Gilaad G, additional, Kappelman, Michael D, additional, Ungaro, Ryan C, additional, Colombel, Jean-Frederic, additional, Brenner, Erica J, additional, Agrawal, Manasi, additional, Reinisch, Walter, additional, Griffiths, Anne M, additional, and Sebastian, Shaji, additional

Published
2021
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