In today's world, stress seems to be omnipresent, and most people have already experienced stress and the resulting negative consequences in physical and mental health. A recent study shows that two out of three people in Germany sometimes feel stressed, and even every fourth person feels stressed frequently (Techniker Krankenkasse, 2021). Furthermore, stress levels in Germany have risen steadily in recent years (Techniker Krankenkasse, 2021). Stress can be defined as “a particular relationship between the person and the environment that is appraised by the person as taxing or exceeding his or her resources and endangering his or her well-being” (Lazarus & Folkman, 1984, p. 19). An individual’s stress reaction consequently depends on the cognitive evaluation of the situation. According to the transactional stress theory, in the primary appraisal, it is classified whether the situation is irrelevant, positive, or stressful for one's own well-being (Lazarus & Folkman, 1984). If it is interpreted as stressful, the secondary appraisal follows. The available resources and coping options are assessed to determine whether they are enough to control the situation (Lazarus & Folkman, 1984). If these are not assessed as sufficient, stress arises, and a stress reaction follows (Lazarus & Folkman, 1984). The body is put in a state of "danger", to which the central nervous system, autonomic nervous system, and endocrine system respond (Kentzler & Richter, 2011). This may have negative mental and physical consequences if the stress is overly intense or lasts too long (Rutsch, 2019). Frequently shown stress reactions are for example irritability, impaired concentration, muscle tension or nervousness (Rutsch, 2019). Long-term effects of stress often include high blood pressure, gastric juice overproduction or vegetative disorders, which can develop into serious subsequent illnesses if left untreated (Rutsch, 2019). Supporting individuals through stress prevention programs therefore appears to be quite necessary. However, there are various approaches when implementing a stress prevention campaign. One is based on the instrumental stress management, which directly addresses the stressor (Kaluza, 2018). Strategies for time management and setting boundaries, for example, are used to try to eliminate or at least reduce the stressor (Kaluza, 2018). If the individual stress enhancers are to be targeted, mental stress management is used where the individual works on its destructive attitudes and thought patterns (Kaluza, 2018). In addition, the regenerative stress management, addresses the individual's stress response through exercise or relaxation techniques (Kaluza, 2018). Admittedly, a variety of stress prevention campaigns have been conducted, using different methods, and targeting different audiences (Bodenmann et al., 2002; Herr et al., 2018; Stier-Jarmer et al., 2016, Niks et al., 2018; Van de Weijer-Bergsma et al., 2014). In summary studies confirm that stress prevention programs have proven to be useful and effective in the work setting (Herr et al., 2018; Niks et al., 2018) as well as in private life (Bodenmann et al., 2002; Stier-Jarmer et al., 2016). For example, an intervention based on the transactional stress model indicated improvement in personal coping skills and less usage of dysfunctional thoughts and additudes, even two years after the stress prevention program (Bodenmann et al., 2002). Moreover, in work environments, the long-term effectiveness of stress prevention was evident in the improvement of mental and sleep problems and the reduction of reactivity regarding interpersonal problems (Herr et al., 2018). Nevertheless, there are settings that are particularly affected by stress. In fact, school, university, and work are the most common stressors, followed by peoples’ excessive internal demands (Techniker Krankenkasse, 2021). For this reason, a setting-based approach to prevention seems more relevant in this context than an individual-based intervention. Setting-based prevention focuses on a more holistic view of health, emphasizing that people's living space has a significant influence on their wellbeing (Dooris et al., 1998). The aim of a setting-based prevention is therefore to support and stabilize health of individuals in the respective setting through setting-based interventions (Dooris et al., 1998). Indeed, setting-based prevention approaches were found to be particularly effective at universities (Conley et.al, 2015; Fernandez et al., 2016). Conley and colleagues (2015) made clear that setting-based prevention approaches at universities contributed to the change of important domains, which led to a reduction in students' perception of stress. In addition, the study by Fernandez and colleagues (2016) considered university employees as well as students. It was shown that changes or improvements in the way knowledge is communicated were most effective in promoting mental health (Fernandez et al., 2016). As described above, setting-based approaches have proven to be effective. In times of pandemics and the ongoing development of technical possibilities, setting-based stress prevention using various electronic-health (e-health) applications seems to be a promising strategy (Tebeje & Klein, 2021; Kwankam, 2004). E-health is “an emerging field in the intersection of medical informatics, public health and business, referring to health services and information delivered or enhanced through the Internet and related technologies” (Eysenbach, 2001, p.1). However, based on the research available to date, the use of e-health applications is already more widespread in other areas of health interventions for example in topics of dietary change and physical activity (Turner-McGrievy et al., 2013; Fukuoka et al., 2010) rather than for use in stress prevention campaigns. For example, Fukouka and colleagues (2010) confirmed that the average daily steps of the participants of a three-week mobile phone-based intervention on physical activity increased. Furthermore, it was shown that participants who used a mobile app to self-monitor their physical activity and eating habits exercised more often during the trial period of six months (Turner-McGrievy et al., 2013). It therefore seems surprising that e-health applications are hardly used for stress prevention campaigns since individuals gain, through the advancement and use of e-health, advantages in terms of accessibility to important health information and the ability to change their own unhealthy patterns (Kreps & Neuhauser, 2010). Moreover, previous research suggests that the additional use of social media in health interventions leads to a positive effect in terms of adherence (Al-Eisa et al., 2016). Al-Eisa and collegues (2016) reported that adherence regarding the improvement of physical fitness was strengthened by the additional use of Instagram. It was used as a motivational stimulus which included educational input on the benefits of physical activity and an alarm function for the participants to remember to do their workout (Al-Eisa et al., 2016). However there has been no research on the impact in terms of adherence through a setting-based stress prevention campaign via Instagram which is unexpected as the popularity and prevalence of social media has grown worldwide in recent years (Boyd & Ellison, 2007) and offers many benefits, especially in times of pandemics. Considering the previous findings, the aim of this paper is therefore to conduct a setting-based stress prevention campaign for university members via an online learning platform and to investigate whether the additional use of Instagram shows a significant effect on participants' adherence. In addition, it is intended to show that a university stress prevention campaign improves life satisfaction, stress resistance, and perceived stress among the participants, whereby a stronger improvement is expected among the individuals who additionally use the Instagram profile.