592 results on '"Baydas A"'
Search Results
152. Effects of Certain Micronutrients and Melatonin on Plasma Lipid, Lipid Peroxidation, and Homocysteine Levels in Rats
- Author
-
Baydas, Giyasettin, Yilmaz, Okkes, Celik, Sait, Yasar, Abdullah, and Gursu, M.Ferit
- Published
- 2002
- Full Text
- View/download PDF
153. Antioxidant Vitamin Levels in Term and Preterm Infants and Their Relation to Maternal Vitamin Status
- Author
-
Baydas, Giyasettin, Karatas, Fikret, Gursu, M.Ferit, Bozkurt, H.Ayse, Ilhan, Nevin, Yasar, Abdullah, and Canatan, Halit
- Published
- 2002
- Full Text
- View/download PDF
154. Variation of K X-ray fluorescence cross-sections of Ti, V and Cr in halogens compounds in energy interval 5.5– [formula omitted]
- Author
-
Baydaş, E., Söǧüt, Ö., Şahin, Y., and Büyükkasap, E.
- Published
- 2002
- Full Text
- View/download PDF
155. An examination of interactions in a three-dimensional virtual world
- Author
-
Turkan Karakus, Rabia Meryem Yilmaz, Yüksel Göktaş, Ozlem Baydas, and Belirlenecek
- Subjects
General Computer Science ,Depth of interaction ,Virtual world ,Spatial ability ,Interactive learning environments ,Virtual reality ,Affect (psychology) ,Metaverse ,Media in education ,Education ,User engagement ,Human–computer interaction ,Duration (project management) ,Psychology - Abstract
Karakus Yilmaz, Turkan/0000-0002-5809-3962; Baydas Onlu, Ozlem/0000-0002-5812-7085; Yilmaz, Rabia/0000-0002-0453-1357 WOS: 000363818800022 Three-dimensional (3D) virtual worlds hold the users' attention by providing rich interaction in an environment similar to the real world. User engagement duration is known to increase in environments with intense interaction. However, information in the literature about whether gender, experience, or spatial ability affects interaction in these environments is limited. In this study, these three factors are compared to users' depth of interaction in a 3D virtual world. In addition, the relationships between engagement duration, spatial ability, and depth of interaction are examined to investigate whether the first two factors can predict the third. Findings showed that users' depth of interaction was not influenced by gender, but experience and spatial ability did affect interaction. A strong relationship was determined between depth of interaction and engagement duration, and a moderate relationship was found between depth of interaction and spatial ability. Findings indicated that when designing 3D environments, it is important to consider which kinds of tasks provide more interaction and to what extent spatial abilities affect interaction, as well as to prepare activities that will increase engagement duration and to devise strategies to enhance depth of interaction. (C) 2015 Elsevier Ltd. All rights reserved. Effects of Virtual and Multimedia Environments on Interest and Awareness towards Winter Sports [111K516]; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) This study was conducted as part of project number 111K516, the Effects of Virtual and Multimedia Environments on Interest and Awareness towards Winter Sports, and supported by the Scientific and Technological Research Council of Turkey. more...
- Published
- 2015
- Full Text
- View/download PDF
156. Educational technology research trends from 2002 to 2014
- Author
-
Yüksel Göktaş, Rabia Meryem Yilmaz, Sevda Kucuk, Melike Aydemir, Ozlem Baydas, and Belirlenecek
- Subjects
Data collection ,Research methodology ,Management science ,Computer science ,Educational technology ,General Social Sciences ,Subject (documents) ,Sample (statistics) ,Library and Information Sciences ,Trends in research designs ,Field (computer science) ,Computer Science Applications ,Sample size determination ,Content analysis ,Mathematics education ,Qualitative research - Abstract
Kucuk, Sevda/0000-0002-2679-5177; Baydas Onlu, Ozlem/0000-0002-5812-7085; Yilmaz, Rabia/0000-0002-0453-1357 WOS: 000361992800046 This study examined subject and research method trends in educational technology field from 2002 to 2014. Content analysis was applied in order to analyze 1255 articles published in BJET and ETR&D journals using the Educational Technology Papers Classification Form. According to the results, learning approaches/theories and learning environments were the subject most preferred by researchers. The most commonly used research methods were quantitative, qualitative, other (review or meta-analysis), and mixed method, in that order. Researchers tended to use questionnaires, documents, and interviews as data collection tools. The most commonly preferred sample type was the purposive sample, and undergraduate students were the most commonly chosen sample group, with the most common sample size being groups of 31-100. Frequencies, percentages, and tables were the most common presentation format for data in quantitative studies, while qualitative studies most often employed content analysis. more...
- Published
- 2015
- Full Text
- View/download PDF
157. Retention and flow under guided and unguided learning experience in 3D virtual worlds
- Author
-
Yüksel Göktaş, Ozlem Baydas, Mehmet Ertuğrul Öztürk, F. Burcu Topu, Rabia Meryem Yilmaz, and Turkan Karakus
- Subjects
Relation (database) ,Virtual world ,Instructional design ,Computer science ,Applied psychology ,Sample (statistics) ,Metaverse ,Human-Computer Interaction ,Learning experience ,Arts and Humanities (miscellaneous) ,Social psychology ,General Psychology ,Avatar ,Instructional simulation - Abstract
Solely flow scores have no difference for both cases in 3D virtual world.Solely retention scores are higher under teacher guidance in 3D virtual world.Retention scores are significantly higher when the user has a 3D virtual world experience.Flow and retention has a strong relationship in unguided, experienced and inexperienced groups. Whatever technology is used, instructional design and media characteristics has a significant effect on the learning experience. 3D virtual worlds allowing a broad range of instructional approaches still need to be worked on to reveal better ways to design instruction. This study investigated the effects in a three-dimensional (3D) virtual world of guidance provided by the instructor's avatar, and of user's virtual world experience on participants' retention scores and flow experiences. Additionally, relationships between retention score and flow were determined in relation to the same variables. Non-experimental, relational, and comparative methods were used. The research sample included a total of 146 undergraduate students from two different departments. Two different scales were used to measure flow and retention. The findings show that the participants' retention scores differed depending on such variables as the experience and guidance by the instructor's avatar while there is no difference in flow experience. The study implicates that instructor guidance is important to improve learning in 3D virtual worlds. more...
- Published
- 2015
- Full Text
- View/download PDF
158. EVALUATION OF THE EFFECT OF POMEGRANATE FLOWERS ON ANTIOXIDANT ACTIVITY AND BDNF LEVELS IN EXPERIMENTAL RENAL FAILURE IN RATS.
- Author
-
Mis, Leyla, Baydas, Burhanettin, and Yasar, Semih
- Abstract
This study was performed with the aim of researching the effects of pomegranate flower on antioxidant activity and BDNF levels in rats with experimental renal failure induced. With this aim, 42 adult Wistar albino rats were used. Rats were divided into 6 groups containing 7 rats according to the amount of pomegranate flower administered. The groups were named control, 20% pomegranate flower, 10% pomegranate flower, 20% pomegranate flower+gentamicin, 10% pomegranate flower+gentamicin and gentamicin group. Diets were prepared containing 20% and 10% pomegranate flower. The relevant groups were fed with this diet for 4 weeks. In the final week, gentamicin was administered by ip injection for 8 days. The lipid peroxidation (malondialdehyde, MDA), glutathione (GSH), Glutathhion peroxidase (GSH-Px) and superoxide dismutase (SOD) levels in blood were researched. Compared with the control group, rats administered different doses of pomegranate flower had significant reductions observed in serum lipid peroxidation levels, while there was clear increase in GSH,GSH-Px and SOD levels identified. Groups administered 20% pomegranate flower had an increase identified in BDNF levels. In conclusion, our fmdings support the view that pomegranate flower may have strong antioxidant activity and increase serum BDNF levels. [ABSTRACT FROM AUTHOR] more...
- Published
- 2021
159. Teachers' views on the use of e-book and tablet in high schools
- Author
-
Önder Yildirim, Ozlem Baydas, Yüksel Göktaş, and Baydaş, Özlem
- Subjects
Social ,E-Kitap ,E-kitap,Tablet ,Tablet ,FATİH Projesi ,Sosyal - Abstract
MEB tarafından Fatih projesi kapsamında önce pilot sonrasında da proje kapsamındaki tüm okulların sınıflarına etkileşimli tahta kurulmakta ve tüm öğrencilere tablet verilmektedir. Bu çalışmada öğretmen görüşlerine göre tabletler üzerindeki e-kitapların öğretmen ve öğrenciler tarafından derslerde kullanımına yönelik avantaj ve dezavantajlarını, kullanım sıklıklarını ve sunulan önerileri ortaya çıkarmak amaçlanmaktadır. Bu doğrultuda Erzincan ve Erzurum illerinde Fatih projesi kapsamında pilot uygulama okulu olan iki lisede görev yapan 38 öğretmenden açık uçlu anket sorularıyla görüşleri alınmıştır. Elde edilen veriler içerik analiz yöntemi ile analiz edilmiştir. Analiz sonucuna göre 27 öğretmenin e-kitapları derslerinde zaman zaman kullandığı, 17 öğretmenin ise hiç kullanmadığı tespit edilmiştir. E-kitap kullanan öğretmenler, e-kitapların görsellik katarak dersleri zenginleştirdiğini ve zaman kazandırdığını fakat ders içi kullanımının ve denetiminin zor olduğunu dile getirmişlerdir. Öğretmenler, öğrencilerin tabletleri amacına uygun kullanmadıklarını (oyun, sosyal ağlar, internet vb.) bundan dolayı da derse karşı ilgilerinin azaldığını vurgulamışlardır In the scope of the Fatih Project started by ministry of Education, interactive boards were setup to all pilot schools and then to other schools and tablets computers were delivered to all students in the schools. The aim of this study is to reveal the advantages and disadvantages, the offered suggestions and the frequency of the usage of the e-books on these tablet computers in the lessons according to teachers’ views. Therefore, the views are taken from 38 teachers who served in two pilot high schools which are located in Erzurum and Erzincan by using open-ended survey questions. The obtained data was analyzed by content analysis. As a result, it was determined that 27 teachers sometimes use e-books, 17 teachers never use e-books. The teachers who use e-books expressed that e-books enriched the lessons adding visuals and saved time, but usage and control of e-books are difficult. Moreover, the teachers emphasized that the students tend to use tablet computer for applications (games, social networks, internet etc.) that does not fit the purpose of the tablet computers and these applications decreased the interest of the students to the lessons more...
- Published
- 2017
- Full Text
- View/download PDF
160. Lactobacillus reuteri’den elde edilen KZYA’nin insan kolon kanser hücrelerinde (HT-29) apoptotik etkileri
- Author
-
DARENDELİOGLU, Ekrem, ÇİFTCİ, Mehmet, and BAYDAS, Gıyasettin
- Subjects
Engineering ,Kolon kanseri,Probiyotikler,L. reuteri,HT-29,KZYA,ROS,LPO ,Mühendislik ,Colon cancer,Probiotics,L. reuteri,HT-29,SCFAs,ROS,LPO - Abstract
Colon cancer is oneof the leading causes of death around the World. In colon or other types ofcancer, chemical methods can be considered as a therapeutic strategy. However,probiotics can also be used as biotherapeutics to reduce recurrence and sideeffects in patients with colon cancer.Short Chain FattyAcids (SCFAs) the fermentation products of probiotic L. reuteri bacteria found in the gastrointestinal tract. There areseveral SCFAs including acetic, propionic, butyric and lactic acids that havebeen shown to have apoptosis inducing properties in human colon cancer cells.In this study, the anti-proliferative and pro-apoptotic activities ofprobiotics were explained and the effects of SCFAs produced by L. reuteri on mitochondrial apoptosiswere observed with changes in ROS and LPO production levels on human coloncancer cells (HT-29).Results suggestedthat SCFAs from L. reuteri increasedthe mortality rates of HT-29 cells, increased ROS and LPO production. Inaddition to these effects, downregulation of Bcl-2, elevation of cytochrome cand overproduction of caspase-3 protein in SCFAs-treated HT-29 cells wereobserved. It was concluded that SCFAs from L.reuteri have cytotoxic effects in HT-29 colon cancer cells., Kolon kanseri, dünyadakiönde gelen ölüm nedenlerinden biridir. Kolon veya diğer kanser tiplerinde,kimyasal yöntemler terapötik bir strateji olarak düşünülebilir. Bununlabirlikte, probiyotikler, kolon kanserli hastalarda hastalığın tekrarı ve yanetkilerini azaltmak için biyoterapötikler olarak kullanılabilir. Kısa Zincirli YağAsitleri (KZYA), bağırsakta bulunan probiyotik L. reuteri bakterilerinin fermentasyon ürünleridir. İnsan kolonkanseri hücrelerinde apoptoz indükleyici özelliklere sahip olduğu gösterilen asetik,propiyonik, bütirik ve laktik asitleri içeren birçok KZYA vardır. Bu çalışmada,probiyotiklerin anti-proliferatif ve pro-apoptotik aktiviteleri açıklanmış ve L. reuteri'nin ürettiği KZYA'nin, insankolon kanseri hücrelerinde (HT-29) mitokondriyal apoptoz yolağına etkileri veROS ile LPO üretim düzeylerindeki değişimleri gözlemlenmiştir. Sonuçlara göre, L. reuteri'den elde edilen KZYA, HT-29hücrelerinde mortalite oranını, ROS ve LPO üretimini anlamlı şekildeartırmıştır. Bu etkilere ilaveten KZYA ile tedavi edilen HT-29 hücrelerindeBcl-2 seviyesinin azalması, sitokromun c ve kaspaz-3 miktarlarının yükselmesigözlenmiştir. Tüm sonuçlar ışığında L.reuteri kaynaklı KZYA'nin kolon kanseri hücrelerinde sitotoksik etkileriolduğu sonucuna varılmıştır. more...
- Published
- 2017
161. Difference of preservice teachers' acceptance of technology use in future classes by levels and branches
- Author
-
Elif Aktaş, Serap Uzuner Yurt, Ozlem Baydas, Fakülteler, Eğitim Fakültesi, Bilgisayar ve Öğretim Teknolojileri Eğitimi Bölümü, and Baydaş, Özlem
- Subjects
Teknoloji,Öğretmen adayları,Ölçek geliştirme ,Education and Educational Research ,Türkçe Dersi ,Teknoloji ,Eğitim, Eğitim Araştırmaları ,Öğretmen Adayları - Abstract
Bu çalışmanın amacı sınıf ve Türkçe öğretmeni adaylarının gelecekteki derslerinde teknolojikullanma kabullerinin sınıf düzeyi ve bölümler bazındaki farklılıklarını ortaya çıkarmaktır.Araştırmada nicel araştırma yöntemlerinden nedensel karşılaştırmalı desen kullanılmıştır.Çalışmada ölçek geliştirme ve ölçeğin uygulanması amacıyla iki farklı katılımcı grubuylaçalışılmıştır. Çalışmanın ölçek geliştirme aşamasında iki farklı üniversitede öğrenim gören 121Türkçe öğretmeni adayı yer almaktadır. Uygulama verilerinin toplandığı ikinci aşamada ise sınıf(159) ve Türkçe (146) öğretmenliği bölümlerinde 305 öğretmen adayına ulaşılmıştır. Çalışmadayer alan faktörlerin sınıf düzeyi ve branşlara göre farkını belirlemek amacıyla iki yönlü MANOVAtesti kullanılmıştır. Sonuçlara göre Türkçe ve sınıf öğretmenliği bölümlerinde eğitim alanöğretmen adaylarının gelecekteki derslerinde Bilişim Teknoloji kullanma kabulleri arasındafarklılıklar belirlenmiştir. Öğretmen adaylarının sınıf düzeyleri arasında da anlamlı farklılıkortaya çıkmıştır. The aim of this study is to reveal the differences between classroom and departmental acceptanceof technology adoption in future classes of Form and Turkish preservice teachers. Causalcomparative design from the quantitative researches was used in the research. In order toimplement the scale development and scale in the study, two different groups of participants wereworked with. During the scale development phase of the study, there are 121 Turkish preserviceteachers from two different universities. In the second phase, where application data werecollected, 305 preservice teachers were reached in the Form (159) and Turkish (146) teachingdepartments The two-way MANOVA test was used to determine the factors involved in the studyaccording to class level and branches According to the results, there is a difference betweenintention to use Information Technology in future courses of preservice teachers trained inTurkish and Form teacher departments. There was also a significant difference between the classlevels of the preservice teachers. more...
- Published
- 2017
162. [Answers and latencies dichotic digit test normoacoustic majoring in hearing]
- Author
-
Silvana Valeria, Serra, Aden, Diaz Nocera, Mónica, Brizuela, Lorena, Baydas, Jerónimo, Fotinós, Elio Andres, Soria, Maria Bernarda, Lucini, and Mariel Amanda, Serra
- Subjects
Adult ,Male ,Reference Values ,Auditory Perception ,Reaction Time ,Humans ,Female ,Functional Laterality ,Dichotic Listening Tests - Abstract
Neurocognitive assessment by dichotic digit test provides selective stimulation of auditory pathway with contralateral suppression of the ipsilateral showing interhemispheric differences in concurrent tasks. In order to recognize the pattern of responses, recovery order of digits and latencies heard the original test was modified with the addition of a record of an audio track of the responses. The sample includes subjects with a history in hearing specialization linked to the music and listen to comprehensive second language, normoacoustic without otologic diseases or neurological. Sets 20 pairs of dichotic digits with a digital recording for recording the subject's responses was used. The results reveal: right ear advantage in the pattern of correct answers and the order in which the information provided is retrieved. As for the pattern of intrasets latencies an increase to the fourth repeated / digit recovered and more blunder is observed. Declining intratest latencies in the second part of the test suggest positive training. These modifications allow new prospects and existing applications with behavioral tests. more...
- Published
- 2017
163. Decreased saliva/serum irisin concentrations in the acute myocardial infarction promising for being a new candidate biomarker for diagnosis of this pathology
- Author
-
Musa Yilmaz, Ozlem Secen, Suna Aydin, Tuncay Kuloglu, Adil Baydas, Evrim Gul, Suleyman Aydin, Mehmet Kalayci, Mehmet Ali Kobat, Ömer Doğan Alataş, and Mehmet Nesimi Eren
- Subjects
Male ,medicine.medical_specialty ,Saliva ,Physiology ,Myocardial Infarction ,Biochemistry ,Cellular and Molecular Neuroscience ,Endocrinology ,stomatognathic system ,Internal medicine ,Troponin I ,medicine ,Humans ,Myocardial infarction ,Aged ,Salivary gland ,business.industry ,Cardiac muscle ,Skeletal muscle ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Fibronectins ,stomatognathic diseases ,medicine.anatomical_structure ,Biomarker (medicine) ,Female ,business ,Biomarkers - Abstract
Irisin is a muscle-secreted protein. Cardiac muscle produces more irisin than skeletal muscle in response to acute exercise, and is associated with myocardial infarction (MI) in an experimental model induced by isoproterenol in rats. The timing and significance of its release in patients with acute myocardial infarction (AMI) needs further investigation. We have studied the relationship between serum/saliva irisin concentration and AMI in humans. Serum and saliva samples were taken within 3 days of admission in 11 patients with AMI and in 14 matched controls. Salivary gland irisin was detected immunohistochemically, and serum and saliva levels were measured by ELISA. The three major paired salivary glands (submandibular, sublingual and parotid) produce and release irisin into saliva. Troponin-I, CK, CK-MB concentrations in the AMI group gradually increased from up to 12h, while saliva and serum irisin gradually decreased from up to 48 h, compared with the control group (P more...
- Published
- 2014
- Full Text
- View/download PDF
164. Orchestrating learning during implementation of a 3D virtual world
- Author
-
Ozlem Baydas, Fatma Gunay, Murat Çoban, Yüksel Göktaş, Turkan Karakus, Belirlenecek, Karakus Yilmaz, Turkan -- 0000-0002-5809-3962, and Baydas, Ozlem -- 0000-0002-5812-7085
- Subjects
Instructional design ,Management science ,Computer science ,05 social sciences ,050301 education ,Activity theory ,winter sports ,Moderation ,Metaverse ,Orchestrating ,Computer Science Applications ,Variety (cybernetics) ,virtual worlds ,design process ,0502 economics and business ,Media Technology ,Key (cryptography) ,Design process ,Orchestration (computing) ,activity theory ,0503 education ,050203 business & management ,Information Systems - Abstract
There are many issues to be considered when designing virtual worlds for educational purposes. In this study, the term orchestration has acquired a new definition as the moderation of problems encountered during the activity of turning a virtual world into an educational setting for winter sports. A development case showed that community plays a key role in both the emergence of challenges and in the determination of their solutions. The implications of this study showed that activity theory was a useful tool for understanding contextual issues. Therefore, instructional designers first developed relevant tools and community-based solutions. This study attempts to use activity theory in a prescriptive way, though it is known as a descriptive theory. Finally, since virtual world projects have many aspects, the variety of challenges and practical solutions presented in this study will provide practitioners with suggestions on how to overcome problems in future., Turkish Science and Technology Institution Project [111K516], This study was conducted as part of the "Effects of Virtual and Multimedia Environments on Interest and Awareness Towards Winter Sports" project [number "111K516"], supported by the Turkish Science and Technology Institution Project. more...
- Published
- 2016
165. Gamified Learning Environment Scale
- Author
-
Baydas, Ozlem, primary and Cicek, Mithat, additional
- Published
- 2019
- Full Text
- View/download PDF
166. THE PEPTIDOGLYCAN FRACTION ENRICHED WITH MURAMYL PENTAPEPTIDE FROM L actobacillus bulgaricus: INHIBITS GLIOBLASTOMA U373MG CELL MIGRATION CAPABILITY AND UPREGULATES PARP1 AND NF-kB LEVELS.
- Author
-
Nedzvetsky, V. S., Agca, C. A., and Baydas, G.
- Published
- 2020
- Full Text
- View/download PDF
167. Examining the Relationship Between Engagement and Perceived Stress-Related Cognitive Complaints in the Argentinian Working Population.
- Author
-
Ramiro Miranda, Agustín, Rivadero, Luisina, Ángel Bruera, Jorge, Villarreal, Virginia, Yhicel Bernio, Laura, de los Ángeles Baydas, Lorena, Liliana Brizuela, Mónica, and Valeria Serra, Silvana
- Subjects
PERCEIVED Stress Scale ,JOB involvement ,PATH analysis (Statistics) ,COGNITIVE ability ,CIVIL service - Abstract
Stress has a negative impact on cognitive functioning and occupational well-being. The aim of this study was to assess the relationship among perceived stress, cognitive complaints and work engagement in public employees from Córdoba, Argentina. In this cross-sectional study, self-report questionnaires were administered to 240 participants. Spanish versions of the following instruments were used: Perceived Stress Scale (PSS), Utrecht Work Engagement Scale (UWES), Memory Failures in Everyday (MFE), Executive Complaint Questionnaire (ECQ). Statistical analysis included ANOVA, path analysis, and multiple logistic regression. Stressed workers showed lower work engagement and more cognitive complaints, even after adjusting for demographic variables. Negative associations were also observed between work engagement and cognitive complaints, suggesting that cognitive difficulties are related to engagement. Given the relation among stress, cognition, and work engagement, it is important to consider these factors to foster workers' health and work productivity. [ABSTRACT FROM AUTHOR] more...
- Published
- 2020
- Full Text
- View/download PDF
168. Soluble curcumin prevents cadmium cytotoxicity in primary rat astrocytes by improving a lack of GFAP and glucose-6-phosphate-dehydrogenase
- Author
-
Nedzvetsky, V. S., primary, Sukharenko, E. V., primary, Kyrychenko, S. V., primary, and Baydas, G., primary
- Published
- 2018
- Full Text
- View/download PDF
169. An Umbrella Surface in R^3 as An Orbit Surface
- Author
-
Baydas, Senay, primary and Karakas, Bulent, additional
- Published
- 2018
- Full Text
- View/download PDF
170. Effects of Lamotrigine and Topiramate on Brain Maturation and Cognitive Functions in Offspring of Pregnant Rats – Preliminary Study
- Author
-
Mehmet Tuzcu, Zeynep Ozcan Dag, Tahir Kurtuluş Yoldaş, Ramazan Bal, Ersel Dag, Giyasettin Baydas, Bülent Müngen, and Kırıkkale Üniversitesi
- Subjects
Topiramate ,topiramate ,cognitive functions ,Offspring ,business.industry ,Brain maturation ,Medicine (miscellaneous) ,Physiology ,brain development ,Cognition ,Escape latency ,Lamotrigine ,General Biochemistry, Genetics and Molecular Biology ,Anesthesia ,Reviews and References (medical) ,Internal Medicine ,medicine ,Hippocampus (mythology) ,Pharmacology (medical) ,lamotrigine ,Cognitive impairment ,business ,Genetics (clinical) ,medicine.drug - Abstract
TUZCU, MEHMET/0000-0002-1329-3143; Bal, Ramazan/0000-0003-3829-8669; Baydas, Giyasettin/0000-0002-9206-3177 WOS: 000346149200003 PubMed: 25491681 Background. Antiepileptic drugs (AED) which are used to treat seizures in pregnant women, infants, and young children may cause cognitive impairment or other uncertain injury. However, the precise mechanisms responsible for the negative effects of new AEDs like lamotrigine (LTG) and topiramate (TPM) in the developing brain are still unclear. Objectives. To investigate the GFAP, NCAM and S100B levels in the whole brain of newborn rats on postnatal 1 day and in the hippocampus of adult rats to find out the effect of TPM and LTG on cognitive impairment and brain maturation. Material and Methods. Twenty eight pregnant rats were randomly divided into 7 groups with 4 animals in each group. The first group, receiving no drugs, was assigned as the control group. The study groups received intraperitoneal TPM or LTG injections in each trimester. Western blot analysis of the GFAP, NCAM and S100B was performed in the offspring. Behavioral tests were performed at postnatal day 75. Results. The rats in the TPM-I and TPM-III groups had a significant impairment in escape latency on the 5th day as compared to the control rats in a Morris water maze test. In addition, in the expression of astrocyte derived markers, GFAP was upregulated, whereas S100 beta and NCAM were downregulated in the whole brain on postnatal day 1, in offspring exposed to LTG and TPM in utero. Conclusions. The detrimental effects of TPM and LTG appear to be confined particularly to the early stages of brain development. And TPM seems to have a partial role in the cognitive impairment more...
- Published
- 2014
- Full Text
- View/download PDF
171. Customer satısfactıon ın prıvate health organızatıons: an empirical study
- Author
-
Abdulvahap Baydas
- Subjects
jel:M10 ,jel:M31 ,customer satisfaction, service quality, health ,jel:M39 - Abstract
The service sector is developing fast as a result of the complex business environment, changes in the society and individual expectations. One of the fastest growing industries in the service sector is healthcare industry. In protecting people’s health, the quality of service is important for providing better treatment, increasing satisfaction and improving organization's image. Customer satisfaction and service quality are often treated together as functions of customer's perceptions and expectations. This study empirically explores the relationship between hospital quality management and service quality performance for the sample of the patients at the private hospitals in Sivas. The study consists of 148 randomly chosen patients treated in private hospitals. more...
- Published
- 2014
172. Deficiency of a New Protein Associated with Cardiac Syndrome X; Called Adropin
- Author
-
Musa Bulut, Mehmet Balin, Kenan Erdem, Suleyman Aydin, Suna Aydin, Adil Baydas, Yakup Altas, Mehmet Ali Kobat, and Ahmet Çelik
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cardiac syndrome X ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,In patient ,Endothelial dysfunction ,Risk factor ,Aged ,Microvascular Angina ,Pharmacology ,business.industry ,Healthy subjects ,Blood Proteins ,General Medicine ,Middle Aged ,medicine.disease ,Control subjects ,Pathophysiology ,Endocrinology ,ROC Curve ,Intercellular Signaling Peptides and Proteins ,Female ,Multiple linear regression analysis ,Endothelium, Vascular ,Peptides ,Cardiology and Cardiovascular Medicine ,business - Abstract
The pathophysiology of cardiac syndrome X (CSX) is still unclear, but most patients with CSX have endothelial dysfunction. It has been shown that adropin uniquely effects the regulation of endothelial function. The purpose of the study was to evaluate the role of adropin in CSX. Eighty-six consecutive cardiac syndrome X-diagnosed patients and 86 age-sex matched healthy subjects were enrolled into the study. Serum adropin levels, nitrite/nitrate levels were measured in each subject. The adropin levels were significantly lower in patients with CSX than healthy subjects (1.7 ± 0.8 ng/mL and 3.4 ± 1.8 ng/mL, respectively; P < 0.001). The BMI values of patients with CSX were significantly higher than control subjects (28.1 ± 2.4 kg/m(2) and 26.0 ± 3.7 kg/m(2) , respectively; P < 0.001). Plasma nitrite/nitrate levels were lower in patients with CSX than control subjects (15.9 ± 1.6 μmol/L vs. 25.4 ± 2.8 μmol/L, respectively; P < 0.001), and they have a significantly positive correlation with plasma adropin levels (r = 0.463, P < 0.001). In the multiple linear regression analysis, nitrite/nitrate levels, BMI, and adropin were found to be independent risk factors for CSX. A ROC curve is used to identify the ability of adropin levels to predict the cardiac syndrome X. The area under the ROC curve was 0.854 for adropin levels (P = 0.0001). The sensitivity and specificity values of adropin levels were 90.7 and 70.9%, respectively (cut-off value 2.73). In conclusion, lower serum adropin levels were associated with CSX. Adropin is an independent risk factor for CSX. more...
- Published
- 2013
- Full Text
- View/download PDF
173. THE DEMAND FOR FUNDS FROM RURAL CREDIT UNIONS IN TOGO / LA DEMANDE DE FONDS DES COOPERATIVES DE CREDIT AU TOGO
- Author
-
Baydas, Mayada M. and Cuevas, Carlos E.
- Published
- 1990
174. Protective effect of Ginkgo biloba extract on CCI 4-induced liver damage
- Author
-
Bahçecioğlu, I.Halil, Ustundağ, Bilal, Ozercan, Ibrahim, Erçel, Ergül, Baydaş, Giyasettin, Akdere, Taner, and Demir, Ali
- Published
- 1999
- Full Text
- View/download PDF
175. Chemical effects on L X-ray fluorescence cross-sections of Ba, La, and Ce compounds
- Author
-
Baydaş, E., Söğüt, Ö., Şahin, Y., and Büyükkasap, E.
- Published
- 1999
- Full Text
- View/download PDF
176. Pre-service teachers' behavioral intention to make educational animated movies and their experiences (vol 63, pg 41, 2016)
- Author
-
Yilmaz, Rabia M., Baydas, Ozlem, and Belirlenecek
- Abstract
Baydas Onlu, Ozlem/0000-0002-5812-7085 WOS: 000407186500100 …
- Published
- 2017
177. A model for preservice teachers' intentions to use ICT in future lessons
- Author
-
Yüksel Göktaş, Ozlem Baydas, and Belirlenecek
- Subjects
060201 languages & linguistics ,Semi-structured interview ,technology acceptance model ,business.industry ,Multimethodology ,05 social sciences ,050301 education ,Information technology ,06 humanities and the arts ,Structural equation modeling ,Computer Science Applications ,Education ,Intention of ICT usage ,Information and Communications Technology ,0602 languages and literature ,Pedagogy ,Technology integration ,Mathematics education ,Technology acceptance model ,business ,Psychology ,0503 education ,Social influence - Abstract
This study proposes a model for determining preservice teachers’ intentions to use information and communication technology (ICT) in future lessons. Data were collected from 21 preservice teachers via interview in the first stage of the study and from 2904 preservice teachers from 16 different universities via a designed scale in the second stage of the study. Data were analyzed through structural equation modeling. A model capable of explaining 85% of variance in preservice teachers’ intentions to use ICT in their future lessons was developed. Perceived usefulness (PU) was seen to have the highest influence on their intentions, while facilitating conditions, social influence, and anxiety had a low direct effect. In addition, these factors were found to have a high indirect influence on intention through other factors such as PU, perceived ease-of-use, and efficacy.Abbreviations: ICT: information and communication technology; M: mean; SD: standard deviation; SEM: structural equation modeling more...
- Published
- 2017
178. Effects of resveratrol on blood homocysteine level, on homocysteine induced oxidative stress, apoptosis and cognitive dysfunctions in rats
- Author
-
Hüseyin Yüce, Nevgul Demir, Suleyman Koz, Giyasettin Baydas, Halil Ibrahim Ozercan, Ebru Onalan Etem, Sema T. Koz, Tuncay Kuloglu, and Arzu Etem
- Subjects
Male ,medicine.medical_specialty ,Homocysteine ,Morris water navigation task ,Apoptosis ,DNA Fragmentation ,Resveratrol ,medicine.disease_cause ,Polymerase Chain Reaction ,Antioxidants ,Lipid peroxidation ,chemistry.chemical_compound ,Internal medicine ,Stilbenes ,In Situ Nick-End Labeling ,medicine ,Animals ,Rats, Wistar ,Maze Learning ,Molecular Biology ,Aorta ,TUNEL assay ,Methionine ,business.industry ,General Neuroscience ,Rats ,Oxidative Stress ,Endocrinology ,chemistry ,Immunology ,Lipid Peroxidation ,Neurology (clinical) ,Cognition Disorders ,business ,Oxidative stress ,Developmental Biology - Abstract
We aimed to examine the protective effects of resveratrol against homocysteine induced oxidative stress, apoptosis and cognitive impairment. Rats were randomly divided into three groups. Control group received standard rat food; homocysteine group (Hcy group) received daily methionine at a dose of 1g/kg-body weight dissolved in drinking water for thirty days; third group (Hcy+Res group) received same amount of methionine plus 20mg/kg/day resveratrol intraperitoneally for thirty days. Cognitive performances of the animals were tested by Morris water maze test. Then all animals were sacrificed to study lipid peroxidation (LPO), DNA fragmentation and p53 mRNA expression in the rat brain. The aortas of the sacrificed rats were processed for histopathological examination. Apoptosis in the aortas was assessed by TUNEL staining. Resveratrol significantly decreased serum levels of homocysteine, reversed Hcy induced LPO increase, decreased DNA fragmentation and p53 mRNA expression in the rat brains, and improved homocysteine induced impairment of long term spatial memory. Resveratrol could inhibit homocysteine induced apoptosis and histopathological deterioration in the rat aortic sections. In conclusion, resveratrol is effective in preventing homocysteine induced vascular and neural defects. In hyperhomocysteinemic rat model, our findings consequently warrant in future studies to reveal the true improvement mechanism of resveratrol. more...
- Published
- 2012
- Full Text
- View/download PDF
179. Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats
- Author
-
Ramazan Bal, Gaffari Türk, Mustafa Nazıroğlu, Ebru Onalan Etem, Giyasettin Baydas, Tuncay Kuloglu, and Okkes Yilmaz
- Subjects
medicine.medical_specialty ,DNA damage ,Clinical Biochemistry ,Cell Biology ,General Medicine ,Biology ,Epididymis ,medicine.disease_cause ,Biochemistry ,Sperm ,chemistry.chemical_compound ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Imidacloprid ,Internal medicine ,medicine ,DNA fragmentation ,Reproductive system ,Fragmentation (cell biology) ,Oxidative stress - Abstract
Department of Physiology, Bingol University, Bingol, TurkeyWe investigated whether treatment with imidacloprid would indu ce morphological changes, DNA fragmentation, antioxidant imbalanceand apoptosis in the reproductive system of developing male rats. Twenty-fo ur male rats were included in this 90-day study, starting at 7days ofage. The rats were divided into four groups. The first group was used as control. The second, third and fourth groups received oral 0.5-, 2- and8-mg/kgimidacloprid,respectively.Serum,sper mandtestissampleswerecollectedfromallgroups attheendoftheexperimentalperiod.Theweight sof the epididymis, vesicula seminalis, epididymal sperm concentration, body weight gain, t estosterone and reduced glutathione values were lower i ntheimidacloprid-treatedgroupsthanthatinthecontrols.Alltreatedgr oupshadincreasedlipidperoxidation,fattyacidconcentrationsandhigh erratesof abnormal sperm. Apoptosis and fragmentation of seminal DNA were higher in rats treated at the two higher doses of imidacloprid. These resultsshow that this compound has a negative effect on sperm and testis of rats. Copyright © 2012 John Wiley & Sons, Ltd.key words—imidacloprid; oxidative stress; apoptosis; testis; fatty acids more...
- Published
- 2012
- Full Text
- View/download PDF
180. Effects of Melatonin on Memory and Learning Deficits Induced by Exposure to Thinner
- Author
-
Viktor S Nedzvetskii, O. P. Nerush, S. V. Kirichenko, and Giyasettin Baydas
- Subjects
medicine.medical_specialty ,Physiology ,Chemistry ,General Neuroscience ,Hippocampus ,Morris water navigation task ,medicine.disease_cause ,Malondialdehyde ,Melatonin ,chemistry.chemical_compound ,Endocrinology ,medicine.anatomical_structure ,Internal medicine ,Cortex (anatomy) ,Neuroplasticity ,medicine ,Neural cell adhesion molecule ,Oxidative stress ,medicine.drug - Abstract
The neurotoxic effects of thinner, a mixture including aromatic compounds (in particular, toluene) and widely used as an industrial solvent, were examined. Exposure of rats to high inhalation concentrations (3000 p.p.m.) of thinner for 45 days (1 h per day) significantly influenced the cognitive functions and levels of neural cell adhesion molecules (NCAM) in the hippocampus, cortex, and cerebellum of experimental animals. These exposures also caused dramatic increases in levels of LPO (malondialdehyde and 4-hydroxyalkenals) in these cerebral structures, while melatonin administration significantly reduced the LPO amounts in these brain regions. The level of NCAM (180 kDa) decreased significantly in the hippocampus and cortex of thinner-exposed rats. Furthermore, thinner-exposed rats showed cognitive deficits in the passive avoidance and Morris water maze tasks; these negative effects were considerably compensated in rats additionally chronically treated with melatonin. It is concluded that treatment with melatonin prevents the development of learning and memory deficits caused by thinner exposure, possibly by reducing oxidative stress and normalizing the neural plasticity. more...
- Published
- 2012
- Full Text
- View/download PDF
181. Corrigendum to ‘Pre-service teachers' behavioral intention to make educational animated movies and their experiences’ [Computers in Human Behavior 63 (2016) 41–49]
- Author
-
Ozlem Baydas and Rabia Meryem Yilmaz
- Subjects
Human-Computer Interaction ,Pre service ,Arts and Humanities (miscellaneous) ,Applied psychology ,Psychology ,Social psychology ,General Psychology - Published
- 2017
- Full Text
- View/download PDF
182. Gingko biloba Extract Inhibits Oxidative Stress and Ameliorates Impaired Glial Fibrillary Acidic Protein Expression, but Can Not Improve Spatial Learning in Offspring from Hyperhomocysteinemic Rat Dams
- Author
-
Sema T. Koz, Giyasettin Baydas, Suleyman Koz, Viktor S. Nedzvetsky, and Nevgul Demir
- Subjects
Pharmacology ,Hyperhomocysteinemia ,medicine.medical_specialty ,Methionine ,biology ,Glial fibrillary acidic protein ,Ginkgo biloba ,business.industry ,Offspring ,Morris water navigation task ,medicine.disease ,biology.organism_classification ,medicine.disease_cause ,Lipid peroxidation ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Internal medicine ,medicine ,biology.protein ,business ,Oxidative stress - Abstract
We aimed to study the effects of gingko biloba extract (EGb) on oxidative stress, astrocyte maturation and cognitive disfunction in offspring of hyperhomocysteinemic rats. Hyperhomocysteinemia was induced in the pregnant rats by administration of methionine (1 gr/kg body weight) dissolved in drinking water throughout pregnancy. One group of animals has received same amount of methionine plus 100 mg/kg/day EGb during pregnancy. On the postnatal day 1, half of the pups from all groups were sacrificed to study the lipid peroxidation (LPO) in different subfractions of brain. Other half of pups were tested in Morris water maze to assess differences in learning and memory performance at the 75 days of age. Maternal hyperhomocysteinemia significantly increased LPO levels especially in mitochondrial subfraction of fetal pup brains. EGb significantly prevented this LPO inrease. Methionine administration to animals reduced glial fibrillary acidic protein (GFAP) expression in pup brains significantly. EGb administration improved GFAP expression significantly. Offspring of hyperhomocysteinemic animals had poor long term spatial memory performance on Morris water maze and EGb administration had no effect on impaired spatial memory. In conclusion, maternally induced hyperhomocysteinemia significantly increased oxidative stress, decreased expression of GFAP and impaired learning performance. more...
- Published
- 2011
- Full Text
- View/download PDF
183. Forced eruption of palatally impacted maxillary canines with fixed and removable appliances: Case report
- Author
-
HALİCİOGLU, Koray, KİKİ, Ali, YAVUZ, İbrahim, BAYDAS, Bulent, BAİBÜ, Diş Hekimliği Fakültesi, Ortodonti Ana Bilim Dalı, and Halıcıoğlu, Koray
- Subjects
lcsh:RK1-715 ,Diş Hekimliği ,lcsh:Dentistry ,Palatinale gömülü maksiller kaninler,ortodontik sürdürme,sabit ortodontik mekanikler,hareketli ortodontik apareyler,avantaj ve dezavantaj - Abstract
Üst çene ön bölge dişlerinin sürme bozuklukları, yüz estetiğini olumsuz yönde etkileyen bir klinik problemdir. Gömülü dişlerin ark içindeki ideal yerlerine ortodontik olarak sürdürülmesi ve dizilmesi hastaya daha iyi bir gülümseme sağlamaktadır. Bu amaç doğrultusunda, klinisyenin en iyi ortodontik mekaniği seçmesi gerekmektedir. Bu çalışmada palatinale gömülü maksiller kaninlerin sürdürülmesi amacıyla kullanılan ortodontik ve cerrahi tedavi seçenekleri anlatılmış ve palatinal pozisyonda gömülü maksiller kanin dişlerinin sabit ve hareketli ortodontik aygıtlarla sürdürüldüğü iki olgu ve bu mekaniklerin avantaj ve dezavantajları sunulmuştur. Sunulan ikinci olguda retansiyon kroşeleri ve helikal springleri olan basit ve etkili müteharrik aparey ile gömülü dişlerin sürdürüldüğü yeni bir yöntem anlatılmıştır.Anahtar kelimeler: Palatinale gömülü maksiller kaninler, ortodontik sürdürme, sabit ortodontik mekanikler, hareketli ortodontik apareyler, avantaj ve dezavantaj.AbstractEruption anomalies of maxillary anterior teeth are clinical problem which effects facial esthetics. Forced eruption and alignment of impacted teeth into the arch is the best treatment approach and supply a more estetic smile for patient. For this purpose, clinician should be selecting the best ideal orthodontic mechanics. In this study presented that orthodontics and surgery treatment options was evaluated used for forced eruption of palatally impacted maxillary canines and on two cases that is forced eruption of palatally impacted maxillary canines used with fixed and removable orthodontics mechanics and explain that advantages and disadvantages of this mechanics. In the present two case explained new method that is an effective and simple removable appliance for the forced eruption of impacted teeth which included retention clasps and a helical spring.Key words: Palatally impacted maxillary canines, forced eruption, fixed orthodontic mechanics, removable orthodontic appliance, advantage and disadvantages, Üst çene ön bölge dişlerinin sürme bozuklukları, yüz estetiğini olumsuz yönde etkileyen bir klinik problemdir. Gömülü dişlerin ark içindeki ideal yerlerine ortodontik olarak sürdürülmesi ve dizilmesi hastaya daha iyi bir gülümseme doğrultusunda, klinisyenin en iyi ortodontik sağlamaktadır more...
- Published
- 2011
184. Astrogliosis in the hippocampus and cortex and cognitive deficits in rats with streptozotocin-induced diabetes: Effects of melatonin
- Author
-
S. V. Kirichenko, P. A. Nerush, Giyasettin Baydas, and Viktor S Nedzvetskii
- Subjects
medicine.medical_specialty ,Physiology ,General Neuroscience ,Hippocampus ,Morris water navigation task ,Streptozotocin ,medicine.disease ,Malondialdehyde ,Neuroprotection ,Astrogliosis ,Melatonin ,chemistry.chemical_compound ,Endocrinology ,medicine.anatomical_structure ,nervous system ,chemistry ,Internal medicine ,Cortex (anatomy) ,medicine ,Neuroscience ,medicine.drug - Abstract
We examined, using a Western blot technique, the contents and compositions of a specific neuronal protein, NCAM, and of an astrocyte marker, GFAP, in the hippocampus and cortex of rats with streptozotocin (STZ)-induced diabetes and compared these indices with those in control (intact) animals and STZ-diabetic rats treated with melatonin. Behavioral cognitive indices manifested in the passive avoidance test (PAT) and Morris water maze (MWM) learning performance were also estimated in the above groups of animals. As was found, STZ-diabetic rats demonstrated clear cognitive deficits according to the values of the retention latency in the PAT and time of reaching the escape platform in the MWM performance. In these animals, the GFAP content was elevated, and the amount of degraded products of this protein increased, as compared with the control. Simultaneously, considerable down-regulation of the NCAM expression and modifications of NCAM isoform composition were found in diabetic animals. In addition, significantly increased levels of lipid peroxidation (according to the amounts of malondialdehyde + 4-hydroxyalkenals) were measured in the cortex and hippocampus of rats with stable diabetic hyperglycemia. All the above-mentioned shifts were significantly smoothed or even nearly completely compensated in the case of treatment of STZ-diabetic rats with melatonin (10 mg/kg per day). The role of diabetes-related changes in the amount and composition of specific neural and glial proteins in the development of cognitive deficits, the involvement of oxidative stress in the mechanisms of the respective shifts, and possible mechanisms of the neuroprotective effect of melatonin with respect to diabetes-related pathological biochemical and behavioral shifts are discussed. more...
- Published
- 2008
- Full Text
- View/download PDF
185. Melatonin prevents gestational hyperhomocysteinemia-associated alterations in neurobehavioral developments in rats
- Author
-
Mehmet Tuzcu, Sema T. Koz, Giyasettin Baydas, and Viktor S. Nedzvetsky
- Subjects
Male ,medicine.medical_specialty ,Hyperhomocysteinemia ,Offspring ,Morris water navigation task ,Biology ,Melatonin ,Random Allocation ,Endocrinology ,Pregnancy ,Internal medicine ,medicine ,Animals ,Rats, Wistar ,Fetus ,Behavior, Animal ,Glial fibrillary acidic protein ,Neurotoxicity ,medicine.disease ,Rats ,Animals, Newborn ,biology.protein ,Female ,Cognition Disorders ,medicine.drug - Abstract
Chronic hyperhomocysteinemia is a risk factor in cardiovascular diseases and neurodegeneration. Among the putative mechanisms of homocysteine-induced neurotoxicity, an increased production of reactive oxygen species has been suggested. However, elevated homocysteine levels might disturb neurogenesis during brain development and lead to persistent congenital malformations in the fetus. In this study, we examined whether administration of melatonin inhibits maternal hyperhomocysteinemia-induced cognitive deficits in offspring. Hyperhomocysteinemia was induced in female rats by administration of methionine during pregnancy at a dose of 1 g/kg body weight dissolved in drinking water. Some animals received methionine plus 10 mg/kg/day melatonin subcutaneously throughout pregnancy. The levels of glial fibrillary acidic protein, S100B protein, and neural cell adhesion molecules were determined in the brain tissue from the pups. Learning and memory performances of the young-adult offspring were tested using the Morris water maze test. There were significant reductions in the expression of glial fibrillary acidic protein and S100 B protein in the brains of pups from hyperhomocysteinemic rat dams. Furthermore, maternal hyperhomocysteinemia altered the expression pattern of neural cell adhesion molecules in the fetal brain. In addition, maternal hyperhomocysteinemia significantly reduced learning abilities in offspring. Treatment with melatonin during pregnancy improved learning deficits and prevented the reduction of glial and neuronal markers induced by hyperhomocysteinemia. In conclusion, administration of melatonin throughout pregnancy reduces the effects of hyperhomocysteinemia on the development of fetal brain; therefore, it might be beneficial in preventing persistent congenital malformations. more...
- Published
- 2008
- Full Text
- View/download PDF
186. Pre-service teachers' behavioral intention to make educational animated movies and their experiences
- Author
-
Ozlem Baydas, Rabia Meryem Yilmaz, and Belirlenecek
- Subjects
Expectancy theory ,Educational animated movies ,Experience ,Class (computer programming) ,Data collection ,Process (engineering) ,05 social sciences ,050301 education ,Behavioral pattern ,Intention to use ICT ,Life skills ,Human-Computer Interaction ,Entertainment ,Arts and Humanities (miscellaneous) ,Order (business) ,0502 economics and business ,ComputingMilieux_COMPUTERSANDEDUCATION ,Mathematics education ,Pre-service teachers ,Psychology ,0503 education ,Social psychology ,050203 business & management ,General Psychology - Abstract
Educational animated movies are one of the most entertainment format to deliver any educational messages. These movies can be used a wide range of educational subject areas such as science, engineering and daily life skills procedures. The purpose of this study is to determine the behavioral intention of pre-service teachers while preparing educational animated movies, the factors influencing such behavioral intention, and their experiences. The sample consists of 98 (52 males and 46 females) pre-service teachers studying Department of Computer Education and Instructional Technology. As data collection tools, two different scales were used in order to determine the levels of attitude of the pre-service teachers towards making animated movies and their experiences such as their cooperative communication levels, levels of enjoyment and having difficulty. They prepared the animated movies for class use during five weeks. According to the findings, they were willing to make animated movies in their future lessons. In addition, they enjoyed it, did not experience much difficulty, and engaged in cooperative communication with one another. Performance expectancy was seen to have the highest mean and to have a significant influence on behavioral intention. This research is significant because process of preparing movies is easy and achievable and thus encourages all branch teachers to use this technology in their lessons. The pre-service teachers intended to prepare animated movies in their future lessons.Performance expectancy was the most important factor influential on intention to use.They enjoyed the activity greatly and did not experience much difficulty.They frequently chosen a character after they had chosen scene while creating movies.They engaged in cooperative communication in the process of creating animated movies. more...
- Published
- 2016
187. Corrigendum to ‘Pre-service teachers' behavioral intention to make educational animated movies and their experiences’ [Computers in Human Behavior 63 (2016) 41–49]
- Author
-
Yilmaz, Rabia M., primary and Baydas, Ozlem, additional
- Published
- 2017
- Full Text
- View/download PDF
188. The Level of hs-CRP in Coronary Artery Ectasia and Its Response to Statin and Angiotensin-Converting Enzyme Inhibitor Treatment
- Author
-
Hidayet Kayançiçek, Yilmaz Ozbay, Mehmet Balin, Mehmet Akbulut, Hasan Korkmaz, and Adil Baydas
- Subjects
Male ,Simvastatin ,medicine.medical_specialty ,Statin ,Article Subject ,medicine.drug_class ,Immunology ,Angiotensin-Converting Enzyme Inhibitors ,Coronary Artery Disease ,Coronary Angiography ,Gastroenterology ,Coronary artery disease ,Internal medicine ,Ectasia ,lcsh:Pathology ,medicine ,Humans ,Endothelial dysfunction ,Aged ,Immunoassay ,biology ,business.industry ,Coronary artery ectasia ,C-reactive protein ,Angiotensin-converting enzyme ,Cell Biology ,Middle Aged ,Prognosis ,medicine.disease ,Coronary Vessels ,C-Reactive Protein ,Treatment Outcome ,Endocrinology ,ACE inhibitor ,biology.protein ,Female ,business ,Research Article ,Dilatation, Pathologic ,lcsh:RB1-214 ,medicine.drug - Abstract
Background/Aim. Coronary artery ectasia (CAE) was thought of as a variant of atherosclerosis. C-reactive protein (CRP) which is among the most sensitive markers of systemic inflammation, and elevation of systemic and local levels of this inflammatory marker which has been associated with an increased risk for cardiovascular disease in the obstructive coronary artery disease (O-CAD) are well known, but little was known in CAE. The anti-inflammatory effects of statins and the effect of angiotensin-converting enzyme (ACE) inhibitors on endothelial dysfunction are well established in atherosclerosis. The aim of the present study was to investigate CRP level and its response to statin and ACE inhibitor treatment in CAE.Materials and method. We measured serum hs-CRP level in 40 CAE (26 males, mean age:56.32±9years) and 41 O-CAD (34 males, mean age:57.19±10years) patients referred for elective coronary angiography at baseline and after 3-month statin and ACE inhibitor treatment.Results. Plasma hs-CRP levels were significantly higher in CAE group than O-CAD group at baseline (2.68±66mg/L versus1,64±64, resp.,P<.0001). Plasma hs-CRP levels significantly decreased from baseline 3 months later in the CE (from2.68±0.66mg/L to1.2±0.53mg/L,P<.0001) as well as in the O-CAD group (from1.64±0.64mg/L to1.01±0.56mg/L, P<.001).Conclusion. We think that hs-CRP measurement may be a good prognostic value in CAE patients as in stenotic ones. Further placebo-controlled studies are needed to evaluate the clinical significance of this decrease in hs-CRP. more...
- Published
- 2007
- Full Text
- View/download PDF
189. Öğretmenlerin ve Öğretmen Adaylarının BT Kullanma Niyetleri: BT’yi Okullarla Bütünleştirmede Anahtar Faktörler
- Author
-
Ozlem Baydas, Yüksel Göktaş, Fakülteler, Eğitim Fakültesi, Bilgisayar ve Öğretim Teknolojileri Eğitimi Bölümü, and Baydaş, Özlem
- Subjects
Öğretmen Adayı ,BT Kullanma Niyeti ,General Medicine ,lcsh:L ,Öğretmenlerin BT Kullanımı ,lcsh:Education - Abstract
Çalışmada, öğretmen adaylarının gelecekteki derslerinde BT kullanma niyetlerini ve onların niyetlerini gerçekleştirebilmelerini etkileyen faktörleri ortaya çıkarmak amaçlanmıştır. Bu kapsamda nitel içerikli basit betimsel araştırma yöntemi kullanılmıştır. Çalışmada 21 öğretmen adayıyla ve 13 öğretmenle gruplar halinde branş bazında görüşmeler yürütülmüştür. Verilerin analizinde içerik analizi kullanılmıştır. Çalışmanın sonuçlarına göre öğretmen adaylarının gelecekteki derslerinde BT kullanma niyetlerini; BT'ye yönelik yarar algısı, kullanım kolaylığı algısı, sosyal etki, kolaylaştırıcı şartlar faktörleri etkilemektedir. Öğretmen adaylarının BT kullanma niyetlerini gerçekleştirmelerini belirlemek amacıyla öğretmenlerle yapılan görüşmelerde; okulun alt yapı yetersizlikleri, öğrenci profili problemleri, eğitim ve bilgi yetersizlikleri, hizmet öncesi eğitimlerin yetersizlikleri ortaya çıkarılmıştır. The purpose of this study was to reveal the pre-service teachers' intentions to use ICT in their future classes and the factors influential on their realizing their intentions. Simple descriptive research which is qualitative design was used, and branch-based focus group interviews were held with 21 preservice teachers and 13 in-service teachers in three-person groups. Data were analyzed through content analysis, and four factors influential on pre-service teachers' intentions were found to be "perceived usefulness", "perceived ease of use and efficacy", "social influence", and "facilitating conditions". According to the results, the top factors affecting the realization of their intentions were "lack of infrastructure of schools", "student profile problems", "education and knowledge gaps", and "inadequacy of pre-service training". more...
- Published
- 2015
190. Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats
- Author
-
Giyasettin Baydas and Mehmet Tuzcu
- Subjects
Blood Glucose ,Male ,medicine.medical_specialty ,Antioxidant ,medicine.medical_treatment ,Morris water navigation task ,Water maze ,Hippocampus ,Antioxidants ,Diabetes Mellitus, Experimental ,Melatonin ,Lipid peroxidation ,chemistry.chemical_compound ,Escape Reaction ,Memory ,Internal medicine ,Diabetes mellitus ,medicine ,Animals ,Learning ,Vitamin E ,Memory impairment ,Rats, Wistar ,Swimming ,Pharmacology ,medicine.disease ,Glutathione ,Frontal Lobe ,Rats ,Endocrinology ,chemistry ,Lipid Peroxidation ,Psychology ,medicine.drug - Abstract
Previous studies indicate that diabetes mellitus might be accompanied by a certain erosion of brain function such as cognitive impairment. The aim of this study was to examine and compare the effects of melatonin and vitamin E on cognitive functions in diabetic rats. Diabetes was induced in male albino rats via intraperitoneal streptozotocin injection. Learning and memory behaviors were investigated using a spatial version of the Morris water maze test. The levels of lipid peroxidation and glutathione were detected in hippocampus and frontal cortex. The diabetic rats developed significant impairment in learning and memory behaviors as indicated by the deficits in water maze tests as compared to control rats. Furthermore, lipid peroxidation levels increased and glutathione concentration decreased in diabetic rats. Treatment with melatonin and vitamin E significantly ameliorated learning and memory performance. Furthermore, both antioxidants reversed lipid peroxidation and glutathione levels toward their control values. These results suggest that oxidative stress may contribute to learning and memory deficits in diabetes and further suggest that antioxidant melatonin and vitamin E can improve cognitive impairment in streptozotocin-induced diabetes. more...
- Published
- 2006
- Full Text
- View/download PDF
191. Effects of vitamin E against aluminum neurotoxicity in rats
- Author
-
Mehmet Tuzcu, Giyasettin Baydas, A. A. Tikhomirov, V. S. Nedzvetsky, and Abdullah Yasar
- Subjects
Male ,medicine.medical_specialty ,Frontal cortex ,medicine.medical_treatment ,Biophysics ,S100 Calcium Binding Protein beta Subunit ,Biochemistry ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Antioxidants ,Proinflammatory cytokine ,Lipid peroxidation ,Random Allocation ,chemistry.chemical_compound ,Internal medicine ,Glial Fibrillary Acidic Protein ,medicine ,Animals ,Vitamin E ,Hippocampus (mythology) ,Nerve Growth Factors ,Rats, Wistar ,Brain Chemistry ,Glial fibrillary acidic protein ,biology ,Tumor Necrosis Factor-alpha ,Chemistry ,S100 Proteins ,Neurotoxicity ,Brain ,General Medicine ,Glutathione ,medicine.disease ,Rats ,Neuroprotective Agents ,Endocrinology ,biology.protein ,Neurotoxicity Syndromes ,Lipid Peroxidation ,Geriatrics and Gerontology ,Biomarkers ,Aluminum ,Interleukin-1 - Abstract
The present study examined the protective effects of vitamin E against aluminuminduced neurotoxicity in rats. Wistar rats were given daily aluminum via their drinking water containing 1600 mg/liter aluminum chloride for six weeks. Aluminum induced a significant increase in lipid peroxidation (LPO) in hippocampus and frontal cortex. Furthermore, aluminum caused marked elevation in the levels of the glial markers (glial fibrillary acidic protein (GFAP) and S100B) and proinflammatory cytokines (TNF� α and IL�1 β) in both brain areas. Vitamin E treatment reduced the contents of glial markers and cytokines and the levels of LPO. In conclusion, this study demonstrates that vitamin E ameliorates glial acti� vation and reduces release of proinflammatory cytokines induced by aluminum. DOI: 10.1134/S0006297906030023 more...
- Published
- 2006
- Full Text
- View/download PDF
192. Melatonin prevents oxidative stress and inhibits reactive gliosis induced by hyperhomocysteinemia in rats
- Author
-
Mehmet Kaya Ozer, Abdullah Yasar, Sema T. Koz, Giyasettin Baydas, and Mehmet Tuzcu
- Subjects
Male ,medicine.medical_specialty ,Hyperhomocysteinemia ,Administration, Oral ,Biology ,medicine.disease_cause ,Hippocampus ,Biochemistry ,Antioxidants ,Lipid peroxidation ,Melatonin ,chemistry.chemical_compound ,Metabolic Diseases ,Internal medicine ,medicine ,Animals ,Gliosis ,Rats, Wistar ,Homocysteine ,Brain Chemistry ,Cerebral Cortex ,chemistry.chemical_classification ,Glial fibrillary acidic protein ,Glutathione peroxidase ,Neurotoxicity ,General Medicine ,medicine.disease ,Malondialdehyde ,Rats ,Oxidative Stress ,Endocrinology ,chemistry ,biology.protein ,Injections, Intraperitoneal ,Oxidative stress ,medicine.drug - Abstract
Homocysteine (Hcy), an independent risk factor for atherosclerosis, undergoes auto-oxidation and generates reactive oxygen species, which are thought to be main cause of Hcy neurotoxicity. However, the mechanisms leading to neurodegenerative disorders are poorly understood because studies that have investigated the potential neurotoxicity of hyperhomocysteinemia in vivo are scarce. The purpose of this study was to test whether daily administration of methionine, which induces hyperhomocysteinemia, causes glial hyperactivity, and also to investigate the protective effects of melatonin on the brain tissue against oxidative stress of Hcy in rats. There was a significant development of oxidative stress as indicated by an increase in malondialdehyde + 4-hydroxyalkenals in hippocampus and cortex of hyperhomocysteinemic rats, whereas significant reduction was found in the activity of glutathione peroxidase (GSH-Px). Co-treatment with melatonin inhibited the elevation of lipid peroxidation and significantly increased GSH-Px activity in the brain regions studied. Western blot analysis revealed an increase in glial fibrillary acidic protein (GFAP) contents both in hippocampus and frontal cortex (p < 0.001) of hyperhomocysteinemic rats compared to the controls. Administration of melatonin significantly decreased GFAP contents in hippocampus and cortex (p < 0.05). S100B contents increased only in frontal cortex in hyperhomocysteinemic rats compared to the control (p < 0.01) and was inhibited by melatonin treatment (p < 0.01). The present findings show that Hcy can sensitize glial cells, a mechanism which might contribute to the pathogenesis of neurodegenerative disorders, and further suggest that melatonin can be involved in protecting against the toxicity of Hcy by inhibiting free radical generation and stabilizing glial cell activity. more...
- Published
- 2006
- Full Text
- View/download PDF
193. Autorreporte del procesamiento auditivo: ¿Cómo se perciben los individuos normoacúsicos?
- Author
-
Valeria Serra, Silvana, Gisele Tinunin, Paula, Liliana Brizuela, Mónica, de los Ángeles Baydas, Lorena, Andrés Soria, Elio, Villarreal, Virginia, and Ramiro Miranda, Agustín
- Abstract
Copyright of Revista Medica del IMSS is the property of Direccion de Prestaciones Medicas - IMSS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...
- Published
- 2019
194. Comparison of the impact of melatonin on chronic ethanol-induced learning and memory impairment between young and aged rats
- Author
-
Abdullah Yasar, Giyasettin Baydas, and Mehmet Tuzcu
- Subjects
Male ,Aging ,medicine.medical_specialty ,Spatial Behavior ,Morris water navigation task ,Hippocampus ,Hippocampal formation ,medicine.disease_cause ,Melatonin ,Endocrinology ,Escape Reaction ,Memory ,Internal medicine ,Avoidance Learning ,medicine ,Animals ,Learning ,Memory impairment ,Memory disorder ,Effects of sleep deprivation on cognitive performance ,Rats, Wistar ,Neural Cell Adhesion Molecules ,Swimming ,Memory Disorders ,Ethanol ,business.industry ,Brain ,medicine.disease ,Glutathione ,Rats ,Neuroprotective Agents ,Lipid Peroxidation ,business ,Oxidative stress ,medicine.drug - Abstract
Chronic alcohol exposure causes functional and structural changes in nervous system which have all been associated with learning and memory impairments. Furthermore, alcohol consumption has been shown to alter the pattern of neural cell adhesion molecules (NCAM) which are involved in memory processes. In the current work, we investigated the effects of melatonin on learning and memory deficits induced by alcohol exposure in young and aged rats. A group of young rats (3 months old) were administered ethanol for 45 days and half of them were co-treated with melatonin. Similar treatments were performed in the aged (19 months old) rats. Morris water maze test and passive avoidance task were used to assess cognitive performance. Lipid peroxidation (LPO) and glutathione (GSH) levels were determined to characterize the level of oxidative stress in the hippocampus and cortex. NCAM levels were determined by Western blotting in the hippocampal homogenates. There was a significant elevation in LPO levels and a reduction in GSH levels in aged and alcohol-exposed rats. Furthermore, both young and aged rats displayed some cognitive impairment when given with alcohol for 45 days. Co-administration of melatonin with ethanol significantly reduced LPO and elevated GSH levels while improving the learning and memory deficits induced by ethanol; the aged rats exhibited a greater response to melatonin supplementation. Moreover, melatonin modulated NCAM expression in hippocampus. Present findings indicate that exposure to ethanol induces learning and memory deficits probably by generating reactive oxygen species and downregulating NCAM 180 in hippocampus of aged rats. Melatonin improves learning and memory deficits and the behavioral responses of rats to melatonin supplementation are age dependent. more...
- Published
- 2005
- Full Text
- View/download PDF
195. Learning and memory deficits in rats induced by chronic thinner exposure are reversed by melatonin
- Author
-
Abdullah Yasar, Giyasettin Baydas, Faik Ozveren, Ismail Akdemir, and Mehmet Tuzcu
- Subjects
Male ,medicine.medical_specialty ,Central nervous system ,Hippocampus ,Morris water navigation task ,medicine.disease_cause ,Hydrocarbons, Aromatic ,Melatonin ,Lipid peroxidation ,chemistry.chemical_compound ,Endocrinology ,Adjuvants, Immunologic ,Internal medicine ,Neuroplasticity ,medicine ,Animals ,Rats, Wistar ,Maze Learning ,Brain Chemistry ,Memory Disorders ,Malondialdehyde ,Rats ,Oxidative Stress ,medicine.anatomical_structure ,chemistry ,Solvents ,Lipid Peroxidation ,sense organs ,Oxidative stress ,medicine.drug - Abstract
Thinner is a neurotoxic mixture which is widely used as an aromatic industrial solvent. This product has been shown to cause functional and structural changes in the central nervous system. We investigated the effect of exposure to high concentrations (3000 p.p.m.) of thinner for 45 days (1 hr/day) on cognitive functions and the levels of neural cell adhesion molecules (NCAM) and lipid peroxidation products (LPO) in the hippocampus, cortex and cerebellum of rats. The actions of melatonin on the effects produced by thinner exposure were also tested. Thinner exposure caused a significant increase in LPO (malondialdehyde and 4-hydroxyalkenals) in all brain regions. Melatonin administration significantly reduced LPO and elevated glutathione levels in the brain regions. NCAM (180 kDa) was significantly decreased in hippocampus and cortex of thinner-exposed rats. Furthermore, thinner-exposed rats showed cognitive deficits in passive avoidance and Morris water maze tasks, whereas in the rats chronically treated with melatonin these effects were reversed. This study indicates that treatment with melatonin prevents learning and memory deficits caused by thinner exposure possibly by reducing oxidative stress and regulating neural plasticity. more...
- Published
- 2005
- Full Text
- View/download PDF
196. EFFECTS OF MELATONIN ON LIPID PEROXIDATION and ANTI-OXIDANT ENZYME ACTIVITY IN RATS WITH EXPERIMENTALLY INDUCED HYPERTHYROIDISM
- Author
-
Burhanettin Baydas and Ismail Meral
- Subjects
Pharmacology ,endocrine system ,medicine.medical_specialty ,endocrine system diseases ,biology ,Physiology ,medicine.medical_treatment ,Glutathione ,Anti oxidant ,Malondialdehyde ,Enzyme assay ,Melatonin ,Lipid peroxidation ,Superoxide dismutase ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Physiology (medical) ,Internal medicine ,medicine ,biology.protein ,Saline ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
SUMMARY 1. The present study was designed to investigate the effects of high-dose melatonin on lipid peroxidation and anti-oxidant enzyme activity in rats with experimentally induced hyperthyroidism. 2. Twenty-four albino male rats, weighing 240–260 g, were randomly allotted into one of three experimental groups (control, hyperthyroid and hyperthyroid + melatonin treatment), with each group containing eight animals. Hyperthyroidism was induced by a daily with i.p. injection of 200 µg l-thyroxine for 30 days. In addition to l-thyroxin treatment, rats in the hyperthyroid + melatonin treatment group were also given daily i.p. injections of 10 mg/kg melatonin on the last 10 days of l-thyroxine treatment. Control animals received injections of an equivalent volume of saline solution. Rats received the last injection 24 h before being killed. 3. At the end of the experiment, rats in all three groups were fasted for 12 h and killed by cardiac puncture under ether anaesthesia. Blood samples were taken for the determination of malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD) levels and concentrations of tri-iodothyronine (T3) and thyroxine (T4). 4. It was found that MDA and SOD levels and concentrations of T3 and T4 were higher and the GSH level was lower in rats with hyperthyroidism compared with controls. Melatonin treatment decreased the elevated MDA and SOD levels and increased the lowered GSH level to control levels in rats with hyperthyroidism, but did not ameliorate the concentrations of T3 and T4. 5. It was concluded that high-dose melatonin treatment may decrease the hyperthyroidism-induced disturbances of lipid peroxidation and anti-oxidant enzyme activity and oxidative damage. more...
- Published
- 2005
- Full Text
- View/download PDF
197. Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats1
- Author
-
Mehmet Tuzcu, Ertugrul Sonkaya, Abdullah Yasar, Emir Dönder, and Giyasettin Baydas
- Subjects
Pharmacology ,medicine.medical_specialty ,Gabapentin ,Glial fibrillary acidic protein ,biology ,Chemistry ,medicine.medical_treatment ,Central nervous system ,Intraperitoneal injection ,General Medicine ,Hippocampal formation ,medicine.disease ,Malondialdehyde ,Neuroprotection ,chemistry.chemical_compound ,Endocrinology ,medicine.anatomical_structure ,nervous system ,Internal medicine ,Anesthesia ,Diabetes mellitus ,medicine ,biology.protein ,Pharmacology (medical) ,medicine.drug - Abstract
To investigate the effect of gabapentin on neural [neuron-specific enolase (NSE)] and glial markers [glial fibrillary acidic protein (GFAP) and S100B] in different brain regions of diabetic rats. Diabetes was induced by a single intraperitoneal injection of streptozotocine (50 mg/kg body weight). Rats in one diabetic group received gabapentin (50 mg·kg−1·d−1) and rats in the other diabetic group received vehicle only for 6 weeks. The levels of GFAP, S100B, and NSE were determined by immunoblotting in the hippocampus, cortex, and cerebellum. Lipid peroxidation (LPO as malondialdehyde+ 4-hydroxyalkenals) and glutathione (GSH) levels were also determined in the same brain parts. Total and degraded GFAP content and S100B protein expression in different areas of brain tissues significantly increased in diabetic rats compared to control rats. Similarly, NSE levels were also significantly elevated in hyperglycemic rats. In addition, there was a significant increase in LPO levels in the diabetic rat brain compared to control rat brains. Pretreatment with gabapentin prevented the upregulation of GFAP, S100B, and NSE in all brain regions of diabetic rats. The level of LPO was reduced, but not completely halted, by treatment with gabapentin. These results suggest that diabetes causes glial and neuronal injury, possibly as a result of elevated oxidative stress, and that gabapentin protects neurons and glial cells. Thus, we predict that gabapentin treatment will attenuate the hippocampal and cortical neurodegeneration observed during diabetes mellitus in rats. more...
- Published
- 2005
- Full Text
- View/download PDF
198. Melatonin inhibits neural apoptosis induced by homocysteine in hippocampus of rats via inhibition of cytochrome c translocation and caspase-3 activation and by regulating pro- and anti-apoptotic protein levels
- Author
-
Russel J. Reiter, Mehmet Tuzcu, M. Akbulut, S. Tamer, and Giyasettin Baydas
- Subjects
Male ,Hyperhomocysteinemia ,Programmed cell death ,Poly ADP ribose polymerase ,Blotting, Western ,Apoptosis ,Caspase 3 ,DNA Fragmentation ,Pharmacology ,Hippocampus ,Translocation, Genetic ,Melatonin ,Cytosol ,medicine ,Animals ,Rats, Wistar ,Homocysteine ,Neurons ,Caspase-9 ,Glutathione Peroxidase ,biology ,General Neuroscience ,Cytochrome c ,Cytochromes c ,medicine.disease ,Molecular biology ,Mitochondria ,Rats ,Enzyme Activation ,Gene Expression Regulation ,Caspases ,biology.protein ,Lipid Peroxidation ,Poly(ADP-ribose) Polymerases ,medicine.drug - Abstract
In the present study, we examined the molecular mechanism by which homocysteine causes neuronal cell apoptosis. We further investigated the mechanisms of melatonin's ability to reduce homocysteine-induced apoptosis. Consistent with its antioxidant properties, melatonin reduced homocysteine-induced lipid peroxidation and stimulated glutathione peroxidase enzyme activity in hippocampus of rats with hyperhomocysteinemia. Furthermore, melatonin treatment diminished cytochrome c release from mitochondria and reduced caspase 3 and caspase 9 activation induced by hyperhomocysteinemia. Chronic hyperhomocysteinemia also led to poly(ADP-ribose) polymerase cleavage and subsequently DNA fragmentation. Treatment with melatonin markedly inhibited poly(ADP-ribose) polymerase cleavage and reduced DNA damage. Hyperhomocysteinemia caused an elevation of pro-apoptotic Bax levels while reducing anti-apoptotic protein, Bcl-2, levels. Daily administration of melatonin up-regulated Bcl-2 and down-regulated Bax levels. We propose that, in addition to its antioxidant properties, melatonin has the ability to protect neuronal cells against apoptosis mediated homocysteine neurotoxicity by modulating apoptosis-regulatory proteins in the hippocampus of rats. more...
- Published
- 2005
- Full Text
- View/download PDF
199. Exogenous Leptin Increases Lipid Peroxidation in the Mouse Brain
- Author
-
Selim Kutlu, Giyasettin Baydas, Abdullah Yasar, Mehmet Aydin, Mehmet Tuzcu, and Sinan Canpolat
- Subjects
Leptin ,Male ,medicine.medical_specialty ,Antioxidant ,medicine.medical_treatment ,media_common.quotation_subject ,Adipose tissue ,Biology ,medicine.disease_cause ,Antioxidants ,General Biochemistry, Genetics and Molecular Biology ,Immunoenzyme Techniques ,Lipid peroxidation ,Mice ,chemistry.chemical_compound ,Internal medicine ,medicine ,Animals ,media_common ,Mice, Inbred BALB C ,Brain ,Appetite ,Hydrogen Peroxide ,General Medicine ,Glutathione ,Lipids ,Oxidative Stress ,Endocrinology ,chemistry ,Lipid Peroxidation ,Oxidative stress ,Hormone - Abstract
Leptin, a hormone produced by the adipose tissues, reduces appetite and food intake, and increases energy expenditures by sending signals to the brain cells. As human obesity is associated with hyperleptinemia and increased systemic oxidative stress, we investigated whether leptin affects lipid peroxidation and antioxidant status in the brain. Leptin was intraperitoneally administered to adult male BALB/c mice (n = 6) at a dose of 40 mug/animal for 5 days, while control mice (n = 6) received phosphate buffered saline. All animals were decapitated one hour after the last injection, and the brain tissues were removed. Total brain tissues were homogenized with phosphate buffered saline. Lipid hydroperoxide and glutathione levels were measured by enzyme immunoassays. Data were statistically analysed by using Mann Whitney's U-test. Lipid hydroperoxide levels were significantly higher in the brain tissue of leptin-treated mice (3.44 +/- 0.36 nmol/g tissue, mean +/- S.E.M.) than those of the control mice (2.20 +/- 0.38 nmol/g tissue, p0.01). In contrast, leptin-treated mice had significantly lower glutathione levels in the brain tissue compared to the control (12.97 +/- 1.32 and 17.91 +/- 0.82 nmol/g tissue, respectively, p0.05). These results indicate that exogenous leptin increases lipid peroxidation and inhibits antioxidant system in the mouse brain. We therefore suggest that leptin may augment oxidative stress in the brain. more...
- Published
- 2005
- Full Text
- View/download PDF
200. Neuroprotection by -Lipoic Acid in Streptozotocin-Induced Diabetes
- Author
-
Ertugrul Sonkaya, Mehmet Tuzcu, Viktor S Nedzvetskii, Abdullah Yasar, Emir Dönder, M. Kiliboz, and Giyasettin Baydas
- Subjects
Male ,medicine.medical_specialty ,medicine.disease_cause ,Biochemistry ,Neuroprotection ,Antioxidants ,Diabetes Mellitus, Experimental ,Lipid peroxidation ,chemistry.chemical_compound ,Diabetic Neuropathies ,Internal medicine ,medicine ,Animals ,Gliosis ,Rats, Wistar ,Brain Chemistry ,Thioctic Acid ,Glial fibrillary acidic protein ,biology ,General Medicine ,Glutathione ,Streptozotocin ,Rats ,Disease Models, Animal ,Lipoic acid ,Neuroprotective Agents ,Endocrinology ,nervous system ,chemistry ,biology.protein ,medicine.symptom ,Biomarkers ,Injections, Intraperitoneal ,Oxidative stress ,medicine.drug - Abstract
Glial cells provide structural and metabolic support for neurons, and these cells become reactive to any insult to the central nervous system. The streptozotocin (STZ) rat model was used to study glial reactivity and the prevention of gliosis by alpha-lipoic acid (alpha-LA) administration. The expression of glial fibrillary acidic protein (GFAP), S100B protein, and neuron specific enolase (NSE) was determined as well as lipid peroxidation (LPO) and glutathione (GSH) levels in some brain tissues. Western blot analyses showed GFAP, S100B, and NSE levels significantly increased under STZ-induced diabetes in brain, and LPO level increased as well. Administration of alpha-LA reduced the expression both of glial and neuronal markers. In addition, alpha-LA significantly prevented the increase in LPO levels found in diabetic rats. GSH levels were increased by the administration of alpha-LA. This study suggests that alpha-LA prevents neural injury by inhibiting oxidative stress and suppressing reactive gliosis. more...
- Published
- 2004
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.