733 results on '"Bautmans, Ivan"'
Search Results
152. A Comprehensive Overview of Activities of Daily Living in Existing Frailty Instruments: A Systematic Literature Search.
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Costenoble, Axelle, Knoop, Veerle, Vermeiren, Sofie, Vella, Roberta Azzopardi, Debain, Aziz, Rossi, Gina, Bautmans, Ivan, Verté, Dominique, Gorus, Ellen, and Vriendt, Patricia De
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ONLINE information services ,PSYCHOLOGY information storage & retrieval systems ,SOCIAL participation ,LEISURE ,FRAIL elderly ,SYSTEMATIC reviews ,ACTIVITIES of daily living ,BATHS ,OCCUPATIONS ,JOB involvement ,DESCRIPTIVE statistics ,MEDLINE ,SOCIAL skills ,PEOPLE with disabilities ,TRANSPORTATION - Abstract
Background and Objectives The relationship between frailty and disability in activities of daily living (ADLs) can be seen in different ways, with disability being—to varying degrees—a characteristic, negative outcome, or predictor of frailty. This conflation of definitions is partly a result of the different frailty tools used in research. Aiming to provide a comprehensive overview, this systematic literature search analyzed (i) if, (ii) to what extent, and (iii) how ADLs are evaluated by frailty instruments. Research Design and Methods A search was performed in PubMed, Web of Knowledge, and PsycINFO to identify all frailty instruments, followed by categorization of the ADL items into basic (b-), instrumental (i-), and advanced (a-) ADLs. Results In total, 192 articles described 217 frailty instruments, from which 52.1% contained ADL items: 45.2% b-ADLs, 35.0% i-ADLs, and 10.1% a-ADLs. The most commonly included ADL items were bathing (b-ADLs); using transportation (i-ADLs); and semiprofessional work engagement in organized social life or leisure activities (a-ADLs). These instruments all had a multidomain origin (χ
2 = 122.4, p <.001). Discussion and Implications Because 52.1% of all instruments included ADL items, the concepts of frailty and disability appear to be highly entangled. This might lead to circular reasoning, serious concerns regarding contamination, and invalid research results. [ABSTRACT FROM AUTHOR]- Published
- 2021
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153. Muscle changes after stroke and their impact on recovery: time for a paradigm shift? Review and commentary.
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Beckwée, David, Lefeber, Nina, Bautmans, Ivan, Cuypers, Lotte, De Keersmaecker, Emma, De Raedt, Sylvie, Kerckhofs, Eric, Nagels, Guy, Njemini, Rose, Perkisas, Stany, Scheys, Ellen, and Swinnen, Eva
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INFLAMMATION prevention ,INFLAMMATION ,ELDER care ,BIOMARKERS ,CONVALESCENCE ,DIAGNOSIS ,EXERCISE ,GAIT in humans ,INTERDISCIPLINARY research ,EVALUATION of medical care ,MUSCLE strength ,STROKE ,SARCOPENIA ,SKELETAL muscle ,WASTING syndrome ,STROKE rehabilitation ,DISEASE complications ,DISEASE risk factors - Abstract
In stroke rehabilitation there is a growing body of evidence that not all patients have the same potential to recover. Understanding the processes that give rise to the heterogeneous treatment responses in stroke survivors will lay foundations for any conceivable advance in future rehabilitation interventions. This review was set out to shine new light on the debate of biomarkers in stroke rehabilitation by linking fundamental insights from biogerontological sciences to neurorehabilitation sciences. In particular, skeletal muscle changes and inflammation are addressed as two potential constructs from which biomarkers for stroke rehabilitation can be derived. Understanding the interplay between these constructs as well as their relation to recovery could enhance stroke rehabilitation in the future. The rationale for the selection of these constructs is three-fold: first, recent stroke literature emphasizes the importance of identifying muscle wasting (also called stroke-induced muscle wasting) in stroke patients, a concept that is widely investigated in geriatrics but less in the stroke population. Second, insights from transdisciplinary research domains such as gerontology have shown that inflammation has severe catabolic effects on muscles, which may impede rehabilitation outcomes such as gait recovery. Last, it has been proven that (high-intensity) muscle strengthening exercises have strong anti-inflammatory effects in a non-stroke population. Therefore, an evidence-based rationale is presented for developing research on individual changes of muscle and inflammation after a stroke. [ABSTRACT FROM AUTHOR]
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- 2021
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154. Handgrip performance in relation to self-perceived fatigue, physical functioning and circulating IL-6 in elderly persons without inflammation
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Gorus Ellen, Bautmans Ivan, Njemini Rose, and Mets Tony
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Geriatrics ,RC952-954.6 - Abstract
Abstract Background Low grip strength is recognized as one of the characteristics of frailty, as are systemic inflammation and the sensation of fatigue. Contrary to maximal grip strength, the physical resistance of the muscles to fatigue is not often included in the clinical evaluation of elderly patients. The aim of this study was to investigate if the grip strength and the resistance of the handgrip muscles to fatigue are related to self-perceived fatigue, physical functioning and circulating IL-6 in independently living elderly persons. Methods Forty elderly subjects (15 female and 25 male, mean age 75 ± 5 years) were assessed for maximal grip strength, as well as for fatigue resistance and grip work (respectively time and work delivered until grip strength drops to 50% of its maximum during sustained contraction), self perceived fatigue (VAS-Fatigue, Mob-Tiredness scale and the energy & fatigue items of the WHOQOL-100), self rated physical functioning (domain of physical functioning on the MOS short-form) and circulating IL-6. Relationships between handgrip performance and the other outcome measures were assessed. Results In the male participants, fatigue resistance was negatively related to actual sensation of fatigue (VAS-F, p < .05) and positively to circulating IL-6 (p < .05). When corrected for body weight, the relations of fatigue resistance with self-perceived fatigue became stronger and also apparent in the female. Grip strength and grip work were significantly related with several items of self-perceived fatigue and with physical functioning. These relations became more visible by means of higher correlation coefficients when grip strength and grip work were corrected for body weight. Conclusion Well functioning elderly subjects presenting less handmuscle fatigue resistance and weaker grip strength are more fatigued, experience more tiredness during daily activities and are more bothered by fatigue sensations. Body weight seems to play an important role in the relation of muscle performance to fatigue perception. Elderly patients complaining from fatigue should be physically assessed, both evaluating maximal grip strength and fatigue resistance, allowing the calculation of grip work, which integrates both parameters. Grip work might best reflect the functional capacity resulting from the development of a certain strength level in relation to the time it can be maintained.
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- 2007
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155. Reaction time in healthy elderly is associated with chronic low-grade inflammation and advanced glycation end product
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Arnold, Pauline, Njemini, Rose, Vantieghem, Stijn, Gorus, Ellen, Pool-Goudzwaard, Annelies, Buyl, Ronald, Bautmans, Ivan, Arnold, Pauline, Njemini, Rose, Vantieghem, Stijn, Gorus, Ellen, Pool-Goudzwaard, Annelies, Buyl, Ronald, and Bautmans, Ivan
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Chronic inflammation and Advanced Glycation End products (AGE) are associated with sarcopenia. Decreased voluntary muscle activation and increased antagonist coactivation can contribute to age-related muscle weakness. The influence of chronic inflammation and AGE in these neuromuscular mechanisms is not clear. We studied whether a relation exists between circulating levels of inflammatory cytokines and AGEs as well as the interplay between agonist and antagonist muscle activation. We studied 64 community-dwelling old subjects, during a maximal isometric voluntary contraction (MVC) and a reaction-time (RT) test of the upper limb. Twenty-five circulating inflammatory biomarkers were determined. Linear regression showed significant relationships between chronic inflammation and six muscle activation parameters. MIP-1β showed a significant negative relation with antagonist coactivation (during MVC) and antagonist muscle activity during pre-movement time (PMT) and movement time (MT) (during RT). A higher level of pentosidine (AGE) was predictive for a longer PMT. We conclude that in older relatively healthy persons antagonist muscle activation is influenced by chronic inflammation, contributing to age-related muscle weakness. Our results also suggest a mechanical and inflammatory influence of pentosidine in upper limb slowing of movement. These findings show novel insight in underlying mechanisms of age-related muscle weakness.
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- 2018
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156. White blood cell counts in a geriatric hospitalized population: A poor diagnostic marker of infection.
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Compte, Nathalie, Dumont, Laura, Bron, Dominique, De Breucker, Sandra, Praet, Jean Philippe, Bautmans, Ivan, Pepersack, Thierry, Compte, Nathalie, Dumont, Laura, Bron, Dominique, De Breucker, Sandra, Praet, Jean Philippe, Bautmans, Ivan, and Pepersack, Thierry
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Older people suffer more often and from more severe infections than do younger people. Several studies have shown a correlation between higher white blood cell count (WBCC) and the presence of infection. The usefulness of increased WBCC to assess the presence of infection in geriatric patients is debated. To answer this question, we investigated the correlation between the total and differential WBCC and documented infection in hospitalized geriatric individuals., info:eu-repo/semantics/published
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- 2018
157. Quality of Life in Sarcopenia and Frailty
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Rizzoli, René, Reginster, Jean-Yves, Arnal, Jean-François, Bautmans, Ivan, Beaudart, Charlotte, Bischoff-Ferrari, Heike, Biver, Emmanuel, Boonen, Steven, Brandi, Maria-Luisa, Chines, Arkadi, Cooper, Cyrus, Epstein, Sol, Fielding, Roger, Goodpaster, Bret, Kanis, John, Kaufman, Jean-Marc, Laslop, Andrea, Malafarina, Vincenzo, Mañas, Leocadio, Mitlak, Bruce, Oreffo, Richard, Petermans, Jean, Reid, Kieran, Rolland, Yves, Sayer, Avan, Tsouderos, Yannis, Visser, Marjolein, Bruyère, Olivier, Rizzoli, René, Reginster, Jean-Yves, Arnal, Jean-François, Bautmans, Ivan, Beaudart, Charlotte, Bischoff-Ferrari, Heike, Biver, Emmanuel, Boonen, Steven, Brandi, Maria-Luisa, Chines, Arkadi, Cooper, Cyrus, Epstein, Sol, Fielding, Roger, Goodpaster, Bret, Kanis, John, Kaufman, Jean-Marc, Laslop, Andrea, Malafarina, Vincenzo, Mañas, Leocadio, Mitlak, Bruce, Oreffo, Richard, Petermans, Jean, Reid, Kieran, Rolland, Yves, Sayer, Avan, Tsouderos, Yannis, Visser, Marjolein, and Bruyère, Olivier
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The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. They may also contribute to clinical frailty. A gradual erosion of quality of life (QoL) has been evidenced in these individuals, although much of this research has been done using generic QoL instruments, particularly the SF-36, which may not be ideal in older populations with significant comorbidities. This review and report of an expert meeting presents the current definitions of these geriatric syndromes (sarcopenia and frailty). It then briefly summarizes QoL concepts and specificities in older populations and examines the relevant domains of QoL and what is known concerning QoL decline with these conditions. It calls for a clearer definition of the construct of disability, argues that a disease-specific QoL instrument for sarcopenia/frailty would be an asset for future research, and discusses whether there are available and validated components that could be used to this end and whether the psychometric properties of these instruments are sufficiently tested. It calls also for an approach using utility weighting to provide some cost estimates and suggests that a time trade-off study could be appropriate
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- 2018
158. Pitfalls in the measurement of muscle mass: a need for a reference standard
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Buckinx, Fanny, Landi, Francesco, Cesari, Matteo, Fielding, Roger A., Visser, Marjolein, Engelke, Klau, Maggi, Stefania, Dennison, Elaine, Al-Daghri, Nasser M., Allepaerts, Sophie, Bauer, Jurgen, Bautmans, Ivan, Brandi, Maria Luisa, Bruyère, Olivier, Cederholm, Tommy, Cerreta, Francesca, Cherubini, Antonio, Cooper, Cyru, Cruz-Jentoft, Alphonso, Mccloskey, Eugene, Dawson-Hughes, Be, Kaufman, Jean-Marc, Laslop, Andrea, Petermans, Jean, Reginster, Jean-Yve, Rizzoli, René, Robinson, Sian, Rolland, Yve, Rueda, Ricardo, Vellas, Bruno, Kanis, John A., Landi, Francesco (ORCID:0000-0002-3472-1389), Buckinx, Fanny, Landi, Francesco, Cesari, Matteo, Fielding, Roger A., Visser, Marjolein, Engelke, Klau, Maggi, Stefania, Dennison, Elaine, Al-Daghri, Nasser M., Allepaerts, Sophie, Bauer, Jurgen, Bautmans, Ivan, Brandi, Maria Luisa, Bruyère, Olivier, Cederholm, Tommy, Cerreta, Francesca, Cherubini, Antonio, Cooper, Cyru, Cruz-Jentoft, Alphonso, Mccloskey, Eugene, Dawson-Hughes, Be, Kaufman, Jean-Marc, Laslop, Andrea, Petermans, Jean, Reginster, Jean-Yve, Rizzoli, René, Robinson, Sian, Rolland, Yve, Rueda, Ricardo, Vellas, Bruno, Kanis, John A., and Landi, Francesco (ORCID:0000-0002-3472-1389)
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Background: All proposed definitions of sarcopenia include the measurement of muscle mass, but the techniques and threshold values used vary. Indeed, the literature does not establish consensus on the best technique for measuring lean body mass. Thus, the objective measurement of sarcopenia is hampered by limitations intrinsic to assessment tools. The aim of this study was to review the methods to assess muscle mass and to reach consensus on the development of a reference standard. Methods: Literature reviews were performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis working group on frailty and sarcopenia. Face-to-face meetings were organized for the whole group to make amendments and discuss further recommendations. Results: A wide range of techniques can be used to assess muscle mass. Cost, availability, and ease of use can determine whether the techniques are better suited to clinical practice or are more useful for research. No one technique subserves all requirements but dual energy X-ray absorptiometry could be considered as a reference standard (but not a gold standard) for measuring muscle lean body mass. Conclusions: Based on the feasibility, accuracy, safety, and low cost, dual energy X-ray absorptiometry can be considered as the reference standard for measuring muscle mass.
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- 2018
159. The feasibility of whole body vibration in institutionalised elderly persons and its influence on muscle performance, balance and mobility: a randomised controlled trial [ISRCTN62535013]
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Van Hees Ellen, Bautmans Ivan, Lemper Jean-Claude, and Mets Tony
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Geriatrics ,RC952-954.6 - Abstract
Abstract Background Fatigue or lack of interest can reduce the feasibility of intensive physical exercise in nursing home residents. Low-volume exercise interventions with similar training effects might be an alternative. The aim of this randomised controlled trial was to investigate the feasibility of Whole Body Vibration (WBV) in institutionalised elderly, and its impact on functional capacity and muscle performance. Methods Twenty-four nursing home residents (15 female, 9 male; mean age 77.5 ± 11.0 years) were randomised (stratification for age, gender and ADL-category) to 6 weeks static WBV exercise (WBV+, N = 13) or control (only static exercise; N = 11). Outcome measures were exercise compliance, timed up-and-go, Tinetti-test, back scratch, chair sit-and-reach, handgrip strength and linear isokinetic leg extension. Results At baseline, WBV+ and control groups were similar for all outcome variables. Twenty-one participants completed the program and attended respectively 96% and 86% of the exercise sessions for the WBV+ and control groups. Training-induced changes in timed up-and-go and Tinetti-test were better for WBV+ compared to control (p = 0.029 for timed up-and-go, p = 0.001 and p = 0.002 for Tinetti body balance and total score respectively). In an alternative analysis (Worst Rank Score & Last Observation Carried Forward) the differences in change remained significant on the Tinetti body balance and total score. No other significant differences in change between both groups were observed. Conclusion In nursing home residents with limited functional dependency, six weeks static WBV exercise is feasible, and is beneficial for balance and mobility. The supplementary benefit of WBV on muscle performance compared to classic exercise remains to be explored further.
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- 2005
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160. The six-minute walk test in community dwelling elderly: influence of health status.
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Lambert Margareta, Bautmans Ivan, and Mets Tony
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Geriatrics ,RC952-954.6 - Abstract
Abstract Background The 6 minutes walk test (6MWT) is a useful assessment instrument for the exercise capacity of elderly persons. The impact of the health status on the 6MWT-distance in elderly, however, remains unclear, reducing its value in clinical settings. The objective of this study was to investigate to what extent the 6MWT-distance in community dwelling elderly is determined by health conditions. Methods One hundred and fifty-six community dwelling elderly people (53 male, 103 female) were assessed for health status and performed the 6MWT. After clinical evaluation, electrocardiography and laboratory examination participants were categorized into a stratified six-level classification system according to their health status, going from A (completely healthy) to D (signs of active disease at the moment of examination). Results The mean 6MWT-distance was 603 m (SD = 178). The 6MWT-distance decreased significantly with increasing age (ANOVA p = 0.0001) and with worsening health status (ANCOVA, corrected for age p < 0.001). A multiple linear regression model with health status, age and gender as independent variables explained 31% of the 6MWT-distance variability. Anthropometrical measures (stature, weight and BMI) did not significantly improve the prediction model. A significant relationship between 6MWT-distance and stature was only present in category A (completely healthy). Conclusions Significant differences in 6MWT-distance are observed according to health status in community-dwelling elderly persons. The proposed health categorizing system for elderly people is able to distinguish persons with lower physical exercise capacity and can be useful when advising physical trainers for seniors.
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- 2004
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161. Fat makes adolescents feel tired
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Vantieghem, Stijn, Tresignie, Jonathan, Bautmans, Ivan, Provyn, Steven, Anatomical Research and Clinical Studies, Gerontology, Rehabilitation Research, Frailty in Ageing, and Research in Geriatrics and Gerontology
- Published
- 2017
162. Validation of the SarQoL (R), a specific health-related quality of life questionnaire for Sarcopenia
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Beaudart, Charlotte, Biver, Emmanuel, Reginster, Jean-Yves, Rizzoli, René, Rolland, Yves, Bautmans, Ivan, Petermans, Jean, Gillain, Sophie, Buckinx, Fanny, Dardenne, Nadia, Bruyère, Olivier, Gerontology, Frailty in Ageing, and Research in Geriatrics and Gerontology
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Male ,Sarcopenia ,Psychometrics ,questionnaire ,SarQoL® ,Surveys and Questionnaires ,Physiology (medical) ,Humans ,Female ,Orthopedics and Sports Medicine ,reproducibility of results ,Psychometric validation ,Quality Of Life ,Aged - Abstract
BACKGROUND: A specific self-administrated health-related quality of life questionnaire for sarcopenia, the Sarcopenia and Quality Of Life (SarQoL®), has been recently developed. This questionnaire is composed of 55 items translated into 22 questions and organized into seven domains of quality of life. The objective of the present work is to evaluate the psychometric properties (discriminative power, validity, reliability, floor and ceiling effects) of the SarQoL® questionnaire. METHODS: Sarcopenic subjects were recruited in an outpatient clinic in Liège, Belgium and were diagnosed according to the algorithm developed by the European Working Group on Sarcopenia in Older People. We compared the score of the SarQoL® between sarcopenic and non-sarcopenic subjects using a logistic regression after adjustment for potential confounding variables. Internal consistency reliability was determined using Cronbach's alpha coefficient; construct validity was assessed using convergent and divergent validities. Test-retest reliability was verified after a two-week interval using the intra-class correlation coefficient (ICC). At last, floor and ceiling effects were also tested. RESULTS: A total of 296 subjects with a median age of 73.3 (68.9-78.6) years were recruited for this study. Among them, 43 were diagnosed sarcopenic. After adjustment for potential confounding factors, the total score and the scores of the different dimensions of the SarQoL® questionnaire were significantly lower for sarcopenic than for non-sarcopenic subjects (54.7 (45.9-66.3) for sarcopenic vs. 67.8 (57.3 - 79.0) for non sarcopenic, OR 0.93 (95%CI 0.90-0.96)). Regarding internal consistency, the Cronbach's alpha coefficient was 0.87. The SarQoL® questionnaire data showed good correlation with some domains of the Short-Form 36 (SF-36) and the EuroQoL 5-dimension (EQ-5D) questionnaires and with the mobility test. An excellent agreement between the test and the retest was found with an ICC of 0.91 (95% CI 0.82-0.95). At last, neither floor nor ceiling effects were detected. CONCLUSIONS: The SarQoL® questionnaire is valid, consistent, and reliable and can therefore be recommended for clinical and research purposes. However, its sensitivity to change needs to be assessed in future longitudinal studies.
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- 2017
163. Validation of the SarQoL®, a specific health-related quality of life questionnaire for Sarcopenia
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Beaudart, Charlotte, Biver, Emmanuel, Reginster, Jean-Yves, Rizzoli, René, Rolland, Yves, Bautmans, Ivan, Petermans, Jean, Gillain, Sophie, Buckinx, Fanny, Dardenne, Nadia, and Bruyère, Olivier
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ddc:616 - Published
- 2017
164. ER-WCPT congress Liverpool 2016
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Hobbelen, Hans, Bautmans, Ivan, and Bottomley, Jennifer
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Healthy Ageing ,Frailty ,Physical Therapy, Sports Therapy And Rehabilitation ,Fysiotherapie ,Kwetsbaarheid ,Fysiotherapie, Sport Therapie En Revalidatie ,Professional Practice &Amp; Society ,Ouderen ,Physiotherapy ,Elderly People - Abstract
Frailty, a complex phenomenon
- Published
- 2016
165. Safety and tolerability of 6-month supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink in sarcopenic older adults.
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Bauer, Jürgen M., Mikušová, Lucia, Verlaan, Sjors, Bautmans, Ivan, Brandt, Kirsten, Donini, Lorenzo M., Maggio, Marcello, Mets, Tony, Wijers, Sander L. J., Garthoff, Jossie A., Luiking, Yvette, Sieber, Cornel, Cederholm, Tommy, McMurdo, Marion E. T., Seal, Chris, Ceda, Gian Paolo, De Vito, Giuseppe, Donders, Gilbert, Drey, Michael, and Greig, Carolyn
- Abstract
Aims: Safety and tolerability of prolonged supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink (WP-MND) was evaluated in sarcopenic older adults. Methods: A 13-week double-blinded, randomized, isocaloric placebo-controlled trial (PROVIDE study; n = 380) was extended with a voluntary 13-week open-label extension (OLE). OLE participants were randomized to receive daily 1 or 2 servings of WP-MND (21 g protein, 3 g leucine, 10 µg vitD and 500 mg calcium per serving). Gastro-intestinal tolerability, kidney function and serum levels of calcidiol, parathyroid hormone (PTH) and calcium were evaluated at week 0, 13 and 26. Results and discussion: In response to the high daily protein intake (median1.5; IQR: 1.3, 1.7 g/kg BW/day), the estimated glomerular filtration rate (eGFR) increased in the test group during the RCT (p = 0.013). The same trend was observed for those participants with moderate chronic kidney disease. During OLE no eGFR change was observed in any of the groups. Serum calcidiol and calcium reached a plateau after 13-week WP-MND supplementation. As expected, PTH significantly changed in the opposite direction, decreasing during RCT in the test group (T vs C: p < 0.001) and during OLE in former control groups. During RCT, 20/366 participants with normal baseline calcidiol reached levels ≥ 100 nmol/L (T: n = 18; C: n = 2) and 6 developed albumin-corrected calcium levels > 2.55 mmol/L (T: n = 3; C: n = 3), without associated adverse events. Conclusion: A 6 months intervention with up to 2 servings of WP-MND did neither result in kidney function deterioration nor symptoms of vitamin D or calcium toxicity. The product was overall well tolerated. [ABSTRACT FROM AUTHOR]
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- 2020
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166. Strength Endurance Training but Not Intensive Strength Training Reduces Senescence-Prone T Cells in Peripheral Blood in Community-Dwelling Elderly Women.
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Dinh, Hung Cao, Njemini, Rose, Onyema, Oscar Okwudiri, Beyer, Ingo, Liberman, Keliane, Dobbeleer, Liza De, Renmans, Wim, Meeren, Sam Vander, Jochmans, Kristin, Delaere, Andreas, Knoop, Veerle, Bautmans, Ivan, Cao Dinh, Hung, De Dobbeleer, Liza, and Vander Meeren, Sam
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STRENGTH training ,T cells ,BLOOD cells ,OLDER women ,EXERCISE - Abstract
Aging is characterized by a progressive decline in immune function known as immunosenescence. Although the causes of immunosenescence are likely to be multifactorial, an age-associated accumulation of senescent T cells and decreased naive T-cell repertoire are key contributors to the phenomenon. On the other hand, there is a growing consensus that physical exercise may improve immune response in aging. However, the optimum training modality required to obtain beneficial adaptations in older subjects is lacking. Therefore, we aimed to investigate the effects of exercise modality on T-cell phenotypes in older women. A total of 100 women (aged ≥ 65 years) were randomized to either intensive strength training (80% of one-repetition maximum ), strength endurance training (40% one-repetition maximum), or control (stretching exercise) for 2-3 times per week during 6 weeks. The T-cell percentages and absolute counts were determined using flow cytometry and a hematology analyzer. C-reactive protein was measured using immunonephelometry. We report for the first time that 6 weeks of strength endurance training significantly decreased the basal percentage and absolute counts of senescence-prone T cells, which was positively related to the number of training sessions performed. Conceivably, training protocols with many repetitions-at a sufficiently high external resistance-might assist the reduction of senescence-prone T cells in older women. [ABSTRACT FROM AUTHOR]
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- 2019
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167. Strength Endurance Training but Not Intensive Strength Training Reduces Senescence-Prone T Cells in Peripheral Blood in Community-Dwelling Elderly Women
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Cao Dinh, Hung, primary, Njemini, Rose, additional, Onyema, Oscar Okwudiri, additional, Beyer, Ingo, additional, Liberman, Keliane, additional, De Dobbeleer, Liza, additional, Renmans, Wim, additional, Vander Meeren, Sam, additional, Jochmans, Kristin, additional, Delaere, Andreas, additional, Knoop, Veerle, additional, and Bautmans, Ivan, additional
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- 2018
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168. Martin Vigorimeter assesses muscle fatigability in older adults better than the Jamar Dynamometer
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De Dobbeleer, Liza, primary, Theou, Olga, additional, Beyer, Ingo, additional, Jones, Gareth R., additional, Jakobi, Jennifer M., additional, and Bautmans, Ivan, additional
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- 2018
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169. Reaction time in healthy elderly is associated with chronic low-grade inflammation and advanced glycation end product
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Arnold, Pauline, primary, Njemini, Rose, additional, Vantieghem, Stijn, additional, Gorus, Ellen, additional, Pool-Goudzwaard, Annelies, additional, Buyl, Ronald, additional, and Bautmans, Ivan, additional
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- 2018
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170. Advanced Glycation End Products Are Associated With Physical Activity and Physical Functioning in the Older Population
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Drenth, Hans, primary, Zuidema, Sytse U, additional, Krijnen, Wim P, additional, Bautmans, Ivan, additional, Smit, Andries J, additional, van der Schans, Cees, additional, and Hobbelen, Hans, additional
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- 2018
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171. Pitfalls in the measurement of muscle mass: a need for a reference standard
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Buckinx, Fanny, primary, Landi, Francesco, additional, Cesari, Matteo, additional, Fielding, Roger A., additional, Visser, Marjolein, additional, Engelke, Klaus, additional, Maggi, Stefania, additional, Dennison, Elaine, additional, Al‐Daghri, Nasser M., additional, Allepaerts, Sophie, additional, Bauer, Jurgen, additional, Bautmans, Ivan, additional, Brandi, Maria Luisa, additional, Bruyère, Olivier, additional, Cederholm, Tommy, additional, Cerreta, Francesca, additional, Cherubini, Antonio, additional, Cooper, Cyrus, additional, Cruz‐Jentoft, Alphonso, additional, McCloskey, Eugene, additional, Dawson‐Hughes, Bess, additional, Kaufman, Jean‐Marc, additional, Laslop, Andrea, additional, Petermans, Jean, additional, Reginster, Jean‐Yves, additional, Rizzoli, René, additional, Robinson, Sian, additional, Rolland, Yves, additional, Rueda, Ricardo, additional, Vellas, Bruno, additional, and Kanis, John A., additional
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- 2018
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172. Psychometric Properties of the MyotonPRO in Dementia Patients with Paratonia
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Drenth, Hans, primary, Zuidema, Sytse U., additional, Krijnen, Wim P., additional, Bautmans, Ivan, additional, van der Schans, Cees, additional, and Hobbelen, Hans, additional
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- 2017
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173. Self-perceived fatigue in adolescents in relation to body composition and physical outcomes
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Vantieghem, Stijn, primary, Bautmans, Ivan, additional, Tresignie, Jonathan, additional, and Provyn, Steven, additional
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- 2017
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174. Development of a self-administrated quality of life questionnaire for sarcopenia in elderly subjects: the SarQoL
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Beaudart, Charlotte, Biver, Emmanuel, Reginster, Jean-Yves, Rizzoli, René, Rolland, Yves, Bautmans, Ivan, Petermans, Jean, Gillain, Sophie, Buckinx, Fanny, Van Beveren, Julien, Jacquemain, Marc, Italiano, Patrick, Dardenne, Nadia, Bruyere, Olivier, Beaudart, Charlotte, Biver, Emmanuel, Reginster, Jean-Yves, Rizzoli, René, Rolland, Yves, Bautmans, Ivan, Petermans, Jean, Gillain, Sophie, Buckinx, Fanny, Van Beveren, Julien, Jacquemain, Marc, Italiano, Patrick, Dardenne, Nadia, and Bruyere, Olivier
- Abstract
Background: the impact of sarcopenia on quality of life is currently assessed by generic tools. However, these tools may not detect subtle effects of this specific condition on quality of life. Objective: the aim of this study was to develop a sarcopenia-specific quality of life questionnaire (SarQoL, Sarcopenia Quality of Life) designed for community-dwelling elderly subjects aged 65 years and older. Settings: participants were recruited in an outpatient clinic in Liège, Belgium. Subjects: sarcopenic subjects aged 65 years or older. Methods: the study was articulated in the following four stages: (i) Item generation—based on literature review, sarcopenic subjects' opinion, experts' opinion, focus groups; (ii) Item reduction—based on sarcopenic subjects' and experts' preferences; (iii) Questionnaire generation—developed during an expert meeting; (iv) Pretest of the questionnaire—based on sarcopenic subjects' opinion. Results: the final version of the questionnaire consists of 55 items translated into 22 questions rated on a 4-point Likert scale. These items are organised into seven domains of dysfunction: Physical and mental health, Locomotion, Body composition, Functionality, Activities of daily living, Leisure activities and Fears. In view of the pretest, the SarQoL is easy to complete, independently, in ∼10 min. Conclusions: the first version of the SarQoL, a specific quality of life questionnaire for sarcopenic subjects, has been developed and has been shown to be comprehensible by the target population. Investigations are now required to test the psychometric properties (internal consistency, test-retest reliability, divergent and convergent validity, discriminant validity, floor and ceiling effects) of this questionnaire
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- 2017
175. Association between advanced glycation end products and paratonia in alzheimer's disease
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Drenth, Hans, Zuidema, Sytse, Krijnen, Wim, Bautmans, Ivan, van der Schans, Cees, Hobbelen, Hans, Ageing and Allied Health Care, Statistical Techniques for Applied Research, and Healthy Ageing, Allied Health Care and Nursing
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mental disorders ,dementie ,paratonia ,paratonie ,dementia - Abstract
Physical activity has been proven to be effective in improving and sustaining physical and cognitive performance in dementia.
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- 2016
176. La validité prédictive de l'état de fragilité pour l’invalidité des AVQ et l'institutionnalisation
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Vermeiren, Sofie, Vella Azzopardi, Roberta, Beckwee, David, Habbig, Ann-Katrin, Jansen, Bart, Scafoglieri, Aldo, Bautmans, Ivan, Gerontologie, Faculteit van de Geneeskunde en Farmacie, Fragiliteit binnen Gerontologie en Geriatrie, Motorische Revalidatie en Kinesitherapie, Faculteit Lichamelijke Opvoeding en Kinesitherapie, Revalidatie Research, Kinesitherapie, Menselijke Fysiologie en Anatomie, Recht Wetenschap Technologie en Samenleving, Elektronica en Informatica, Lichaamsamenstelling en Morphologie, Ondersteunende Klinische wetenschappen, and Onderzoek in Geriatrie en Gerontologie
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predictive validity ,Disability ,Frailty ,outcome ,institutionalisation ,older adults - Abstract
Objectif: L’objectif de cette étude est de déterminer les preuves disponibles pour le pouvoir prédictif concernant l'état de fragilité (pré-fragile et fragile) chez les personnes vivant à domicile pour l’incidence des limitations dans les AVQ (Activités de base de la vie quotidienne) et l'institutionnalisation. Méthodes: Web of Science, PubMed et PsycInfo ont été examinés systématiquement pour des études prospectives au sujet de la relation entre la fragilité et des limitations des AVQ/institutionnalisation. Les Odds Ratios (OR) et les Risk Ratios (RR) ont été extrahés et/ou calculés, et des méta-analyses ont été réalisées avec Open MetaAnalyst pour évaluer l’association de l’état de fragilité avec la probabilité de développer une limitation des AVQ ou d’être institutionnalisé. Résultats: Treize études décrivant l’association entre la fragilité et la limitation de l'AVQ/institutionnalisation ont été incluses dans la méta-analyse. Les études comprenaient des échelles de fragilité physique, multi-domaine et d’accumulation des déficits. Le niveau d’hétérogénéité (I2) était modéré à élevé dans toutes les méta-analyses. En général, l’état de fragilité augmente le risque de développer une limitation des AVQ (OR=2,05 (1,73-2,44); RR=1,62 (1,50-1,76)) et d’institutionnalisation (OR=1,69 (1,02-2,81); RR=1,65 (1,48-1,84)). Il semble qu’un état fragile est accompagné de OR et RR légèrement élevés par rapport à un état pré-fragile. Conclusion: Notre méta-analyse des études prospectives indique qu’un état de (pré)fragilité augmente le risque pour développer des limitations des AVQ (1.6-2.1) et d’institutionnalisation (1.6-1.7). Ainsi, l’identification et l’intervention prémature pour contrer la (pré)fragilité devraient être des priorités pour permettre les personnes âgées de vivre indépendamment à domicile.
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- 2016
177. Ortho-geriatric co-management of older adults admitted to an orthopaedic ward: clinical and financial impact
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Kayembe, Bobbie, Pien, Karen, Scheerlinck, Thierry, Bautmans, Ivan, Beyer, Ingo, Faculty of Medicine and Pharmacy, Surgical clinical sciences, Medical Imaging, Gerontology, Rehabilitation Research, Frailty in Ageing, and Research in Geriatrics and Gerontology
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- 2016
178. La validité prédictive de l’état de fragilité pour l’hospitalisation et la mortalité
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Vermeiren, Sofie, Vella Azzopardi, Roberta, Beckwee, David, Habbig, Ann-Katrin, Scafoglieri, Aldo, Jansen, Bart, Bautmans, Ivan, Gerontologie, Faculteit van de Geneeskunde en Farmacie, Fragiliteit binnen Gerontologie en Geriatrie, Motorische Revalidatie en Kinesitherapie, Faculteit Lichamelijke Opvoeding en Kinesitherapie, Revalidatie Research, Kinesitherapie, Menselijke Fysiologie en Anatomie, Recht Wetenschap Technologie en Samenleving, Lichaamsamenstelling en Morphologie, Ondersteunende Klinische wetenschappen, Elektronica en Informatica, and Onderzoek in Geriatrie en Gerontologie
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predictive validity ,Frailty ,hospitalisation ,outcome ,Mortality ,older adults - Abstract
Objectif: L’objectif de cette étude est de déterminer les preuves disponibles pour le pouvoir prédictif concernant l'état de fragilité (pré-fragile et fragile) chez les personnes vivantes à domicile pour l’incidence d’hospitalisation et de mortalité. Méthodes: Web of Science, PubMed et PsycInfo ont été examinés systematiquement pour des études prospectives au sujet de la relation entre la fragilité et l’hospitalisation/la mortalité. Les Odds Ratios (OR) et les Risk Ratios (RR) ont été extrahés et/ou calculés, et des méta-analyses ont été réalisées avec Open MetaAnalyst pour évaluer l’association de l’état de fragilité avec la probabilité d’une hospitalisation ou de mortalité prématurée. Résultats: Trente études décrivant l’association entre la fragilité et l’hospitalisation ou la mortalité ont été incluses dans la méta-analyse. Les études comprenaient des échelles de fragilité physique, multi-domaine et d’accumulation des déficits. Le niveau d’hétérogénéité (I2) était modéré à élevé dans toutes les méta-analyses. En général, l’état de fragilité augmente le risque d’hospitalisation (OR=1.82 (1.53-2.15); RR=1.18 (1,10-1,28)) et de mortalité (OR=2,34 (1,77-3,09); RR=1,83 (1,68-1,98)). Il semble qu’un état fragile est accompagné des OR et RR légèrement élevés par rapport à un état pré-fragile. Conclusion: Notre méta-analyse des études prospectives indique qu’un état de (pré)fragilité augmente le risque pour l’hospitalisation (1.2-1.8) et la mortalité (1.8-2.3). Ainsi, l’identification et l’intervention prémature pour contrer la (pré)fragilité devraient être des priorités pour permettre les personnes âgées de vivre indépendamment à domicile.
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- 2016
179. Knee Osteoarthritis: dropouts from exercise programmes have more exercise induced pain and worse health
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Beckwee, David, Vaes, Peter, Scheerlinck, Thierry, Bautmans, Ivan, Rehabilitation and Physiotherapy, Rehabilitation Research, Frailty in Ageing, Gerontology, Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physical Therapy, Manual Therapy, Spine Research Group, Supporting clinical sciences, Faculty of Medicine and Pharmacy, Surgical clinical sciences, Medical Imaging, and Research in Geriatrics and Gerontology
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- 2016
180. Impact of strength training (ST) and aerobic training (AT) on serum levels of inflammatory mediators in relation to pain, adherence and compliance
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Forti, Louis Nuvagah, Beckwee, David, Njemini, Rose, Vaes, Peter, Scheerlinck, Thierry, Bautmans, Ivan, Gerontology, Faculty of Medicine and Pharmacy, Frailty in Ageing, Rehabilitation and Physiotherapy, Rehabilitation Research, Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physical Therapy, Research in Geriatrics and Gerontology, Manual Therapy, Spine Research Group, Supporting clinical sciences, Surgical clinical sciences, and Medical Imaging
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- 2016
181. Un langage unique pour la fragilité - mythe ou réalité?
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Vella Azzopardi, Roberta, Vermeiren, Sofie, Habbig, Ann-Katrin, Bautmans, Ivan, Gorus, Ellen, Petrovic, Mirko, Van Den Noortgate, Nele, Beyer, Ingo, Faculteit van de Geneeskunde en Farmacie, Gerontologie, Fragiliteit binnen Gerontologie en Geriatrie, Recht Wetenschap Technologie en Samenleving, Revalidatie Research, Onderzoek in Geriatrie en Gerontologie, and Diabetes Pathologie & Therapie
- Abstract
Contexte: Un des défis majeurs pour l’utilisation clinique du concept de la fragilité est l’absence de langage commun pour décrire et évaluer ses composantes. Bien que le nombre de publications utilisant les mots-clés (MeSH term) frail elderly a augmenté de façon exponentielle durant ces 30 dernières années, de nouvelles définitions et échelles d’évaluation de la fragilité sont perpétuellement proposées. La Classification Internationale du Fonctionnement, de l’handicap et de la santé de l’OMS (CIF) offre un cadre et un langage universel pour une description précise de l’état de santé et des facteurs associés. But de la recherche: effectuer une revue systématique des échelles de fragilité utilisées chez des personnes d’au moins 65 ans et relier leurs items aux codes de la CIF. Analyser le degré de congruence entre les différentes échelles de fragilité et les domaines de la CIF. Méthode: Une recherche des publications relatives aux échelles de la fragilité a été conduite dans PubMed, Web of Knowledge et PsycINFO en utilisant les mots-clés suivants : ‘frailty, frail elderly, aged, assessment, risk assessment, classification, et diagnosis’. Les items des échelles ainsi identifiées ont été reliés aux codes de la CIF par 3 chercheurs indépendants en utilisant les règles publiées par Cieza ea. (2005). Résultats: 1,984 articles ont été identifiés et les titres, et si nécessaire les abstracts, ont été évalués. 67 publications pertinentes ont été retenues et inclues dans la revue systématique. 79 échelles originales ou adaptées ont ainsi été identifiées par lequel deux échelles ne sont pas suffisamment décrites pour être inclus dans les résultats. Parmi celles-ci 27 échelles utilisent des données subjectives, 6 des données objectives et 44 utilisent une combinaison des deux pour identifier la fragilité. 25 échelles seulement identifient un état de pré-fragilité. Le phénotype de la fragilité décrit par Fried est à la base de 24 échelles pour la fragilité, qui s’adressent exclusivement aux aspects physiques. Une échelle est basée uniquement sur la comorbidité et toutes les autres échelles évaluent deux ou plusieurs domaines de la fragilité (p.ex. combinaison d’aspects médicaux, fonctionnels, cognitifs, psychologiques, ou sociaux). 75 échelles ont pu être liées au domaine Fonction organique de la CIF, 19 aux domaines Structure anatomique et Capacité, 72 échelles étaient liées à Performance, 14 à Facteurs environnementaux et 32 à Facteurs personnels. Une vaste diversité a donc été observée parmi les échelles de la fragilité. Tandis que les domaines Fonction organique et Performance sont bien représentés parmi les items des échelles de la fragilité, d’autres domaines de la CIF, tels Structure organique, Capacité, Facteurs environnementaux et Facteurs personnels sont représentés de façon beaucoup plus limitée. La majorité des échelles de la fragilité distinguent entre personnes âgées robustes et fragiles, sans considérer l’état de pré-fragilité (état intermédiaire sub-clinique) durant lequel les interventions adéquates sont probablement les plus efficaces. Conclusions: Plus de 70 échelles de la fragilité différentes ont été identifiées, potentiellement indiquant une grande diversité dans l’approche clinique. Les domaines de la CIF portant sur la Structure organique, les Capacités et les Facteurs environnementaux sont peu représentés et méritent plus d’attention dans l’élaboration d’un consensus futur pour l’évaluation de la fragilité.
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- 2016
182. Sex difference in the heat shock response to high external load resistance training in older humans
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Njemini, Rose, primary, Forti, Louis Nuvagah, additional, Mets, Tony, additional, Van Roie, Evelien, additional, Coudyzer, Walter, additional, Beyer, Ingo, additional, Delecluse, Christophe, additional, and Bautmans, Ivan, additional
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- 2017
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183. Association between advanced glycation end-products and functional performance in Alzheimer's disease and mixed dementia
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Drenth, Hans, primary, Zuidema, Sytse U., additional, Krijnen, Wim P., additional, Bautmans, Ivan, additional, van der Schans, Cees, additional, and Hobbelen, Hans, additional
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- 2017
- Full Text
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184. Effect of Transcutaneous Electric Nerve Stimulation on Pain after Total Knee Arthroplasty: A Blind Randomized Controlled Trial
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Bautmans, Ivan, primary, Lefeber, Nina, primary, Lievens, Pierre, primary, Scheerlinck, Thierry, primary, Vaes, Peter, primary, and Beckwée, David, additional
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- 2017
- Full Text
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185. Frailty and the Prediction of Negative Health Outcomes: A Meta-Analysis
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Vermeiren, Sofie, primary, Vella-Azzopardi, Roberta, additional, Beckwée, David, additional, Habbig, Ann-Katrin, additional, Scafoglieri, Aldo, additional, Jansen, Bart, additional, Bautmans, Ivan, additional, Verté, Dominque, additional, Beyer, Ingo, additional, Petrovic, Mirko, additional, De Donder, Liesbeth, additional, Kardol, Tinie, additional, Rossi, Gina, additional, Clarys, Peter, additional, Cattrysse, Eric, additional, and de Hert, Paul, additional
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- 2016
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186. Linking Frailty Instruments to the International Classification of Functioning, Disability, and Health: A Systematic Review
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Azzopardi, Roberta Vella, primary, Vermeiren, Sofie, additional, Gorus, Ellen, additional, Habbig, Ann-Katrin, additional, Petrovic, Mirko, additional, Van Den Noortgate, Nele, additional, De Vriendt, Patricia, additional, Bautmans, Ivan, additional, Beyer, Ingo, additional, Verté, Dominque, additional, De Donder, Liesbeth, additional, Kardol, Tinie, additional, Rossi, Gina, additional, Clarys, Peter, additional, Scafoglieri, Aldo, additional, Cattrysse, Eric, additional, de Hert, Paul, additional, and Jansen, Bart, additional
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- 2016
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187. Predicting appendicular skeletal muscle muscle and fat mass with bioelectrical impedance analysis in elderly people with physical function decline - the provide study
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Scafoglieri, Aldo, Clarys-Robion, Jan Pieter, Wijers, Sander, Verlaan, Sjors, de Wilde, Janneke, Mets, Tony, Bautmans, Ivan, Gerontology, Experimental Anatomy, Manual Therapy, Body Composition and Morphology, Department of Social Gerontology, Frailty in Ageing, Research in Geriatrics and Gerontology, and Rehabilitation Research
- Published
- 2015
188. The influence of a 6 month intervention on self-perceived fatigue, body composition and handgrip performance in obese boys
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Vantieghem, Stijn, Provyn, Steven, Tresignie, Jonathan, Bautmans, Ivan, Faculty of Medicine and Pharmacy, Frailty in Ageing, Body Composition and Morphology, Gerontology, Experimental Anatomy, Basic (bio-) Medical Sciences, Rehabilitation Research, Research in Geriatrics and Gerontology, and Anatomical Research and Clinical Studies
- Abstract
Introduction: The main goals of obesity intervention programs are decreasing body weight, fat mass and increasing lean mass. It is generally accepted that fat mass decreases with weight loss, but results on lean mass are inconsistent. The relation between weight-loss induced changes in body composition and fatigue sensations in obese adolescents remain unexplored. This study examined the effect of a 6 months weight loss program on self-perceived fatigue, grip performance and body composition.Methods: 81 obese boys (15±2 years) were examined for body composition (DXA), maximal grip strength, fatigue resistance (the time during which grip strength decreased to 50% of its maximum value during sustained maximal contraction), grip work (calculated as fatigue resistance x 0.75 x maximal grip strength, corresponding to the area under the curve) and self-perceived fatigue (Multidimensional Fatigue Inventory, MFI-20). The boys were divided into 2 groups; a high weight loss group (HWL, >20% body weight) and a low weight loss group (LWL
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- 2015
189. Bone marrow lesions and knee osteoarthritis: using magnetic resonance imaging to visualize mechanical knee load
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Beckwee, David, Vaes, Peter, Shahabpour, Maryam, Muyldermans, Ronald, Rommers, Nikki, Bautmans, Ivan, Rehabilitation and Physiotherapy, Faculty of Physical Education and Physical Therapy, Rehabilitation Research, Frailty in Ageing, Gerontology, Manual Therapy, Spine Research Group, Supporting clinical sciences, Research in Geriatrics and Gerontology, and Medical Imaging
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- 2015
190. Knee osteoarthritis and exercise: do bone marrow lesions relate to treatment outcomes?
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Beckwee, David, Vaes, Peter, Raeymaeckers, Steven, Shahabpour, Maryam, Scheerlinck, Thierry, Bautmans, Ivan, Rehabilitation and Physiotherapy, Faculty of Physical Education and Physical Therapy, Rehabilitation Research, Frailty in Ageing, Gerontology, Manual Therapy, Spine Research Group, Faculty of Medicine and Pharmacy, Medical Imaging and Physical Sciences, Medical Imaging, Surgical clinical sciences, and Research in Geriatrics and Gerontology
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- 2015
191. The Frailty Challenge: Identifying early markers of physical frailty in the oldest old
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Vermeiren, Sofie, Habbig, Ann-Katrin, Vella Azzopardi, Roberta, Scafoglieri, Aldo, Jansen, Bart, Bautmans, Ivan, Faculty of Medicine and Pharmacy, Frailty in Ageing, Law Science Technology and Society, Gerontology, Faculty of Physical Education and Physical Therapy, Body Composition and Morphology, Manual Therapy, Physiotherapy, Human Physiology and Anatomy, Electronics and Informatics, Multidimensional signal processing and communication, Rehabilitation Research, and Research in Geriatrics and Gerontology
- Abstract
Background: The ageing world population brings along many challenges. Active ageing and independent living is the way forward to reduce the burdens of an ageing population. One of the most prominent barriers to active ageing is frailty, recognised as a major geriatric syndrome. The consensus and operationalisation of frailty and pre-frailty still lacks consensus. Fried’s Phenotype (FP), the most accepted frailty approach (2029 WoS citations), consists of 5 components: exhaustion, weight loss, low physical activity, slow walking speed and low grip strength. Pre-frail elderly, defined as an incomplete FP (only 1-2 criteria), are not well described in literature. As an “absolute reserve capacity” approach, FP defines frailty as meeting 3 or more and robust as meeting 0 deficits (figure 1). Since maximal absolute reserve capacity at young age varies considerably amongst individuals, it remains unclear where to draw the line between robust and early frailty (when deficits are not yet apparent). This project, witha focus on physical frailty, is part of a larger multidisciplinary project, exploring frailty in multiple domains (medical, psychosocial, cognitive, environmental).Objectives: Notwithstanding frailty is linked to several domains (social, medical, psychological, etc.), the physical aspect of frailty is a dominating component, which is reflected by the fact that a loss in physical reserve capacity is an indispensable component of all comprehensive frailty scales that exist today. The objective of this study is to identify the early markers of physical frailty in order to enable the oldest old to remain independent as long and as good as possible.This project introduces a new concept of “relative reserve capacity”, reflected by a loss over time. Above 80, loss rates of 2%/year reflect biological ageing. We consider higher loss in relative reserve capacity (e.g. 10%) an early sign of frailty, which can occur without changes in FP- score (which will appear later, when reversibility is more challenging) (figure 1). To detect elderly without deficits, but showing excessive loss in reserve capacity, sensitive and responsive measures covering the 5 components of FP are used in the study. Methods: We target the (apparently) robust elderly and will calculate the odds for developing (pre)frailty over 2 years for the robust, showing high loss compared to those with normal loss in relative reserve. Future plans: The results of this study will allow for a better understanding of the mechanisms by which elderly persons develop pre-frailty and frailty, and will enable us in the future to develop new interventions to prevent or delay the occurrence of frailty in the oldest old. More participants will be recruited and results will be translated into scientific publications on frailty.
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- 2015
192. Validation of bioelectrical impedance analysis (BIA) equations to predict appendicular skeletal muscle and fat mass in older adults with sarcopenia
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Scafoglieri, Aldo, Clarys-Robion, Jan Pieter, Wijers, Sander, Verlaan, Sjors, de Wilde, Janneke, Mets, Tony, Bautmans, Ivan, Gerontology, Experimental Anatomy, Manual Therapy, Body Composition and Morphology, Vriendenkring VUB, Spine Research Group, Department of Social Gerontology, Frailty in Ageing, Research in Geriatrics and Gerontology, Rehabilitation Research, and Faculty of Medicine and Pharmacy
- Abstract
Rationale: No BIA equations exist to predict appendicular skeletal muscle mass (ASMM) and appendicular fat mass (AFM) in older adults with sarcopenia. NHANES public reference values for body composition are applicable only to Hologic DXA systems. Therefore we 1) developed and cross-validated appendicular soft tissue BIA equations with both Hologic and GE Lunar systems as their reference and 2) compared the new ASMMHOLOGIC equation to two previously published BIA equations. Methods: Participants with sarcopenia class I or II were recruited from 18 European study centers for the PROVIDE intervention study (NTR2329). In total, 291 cases having both an evaluable BIA (50kHz) and DXA measurement were included (mean age 77.6±6.9yrs; mean %fat 37.2±5.9%). BIA equations, using DXA-derived ASMM and AFM as the dependent variable, and age, gender, weight, height²/resistance and reactance as independent variables, were developed using multiple linear regressions. Results: Cross-validation resulted in 4 equations using the whole sample. Hologic (n=104): ASMM (kg) = 4.957 + (0.196*Height²/Resistance) + (0.060*Weight) – (2.554*Sex) (R²=0.90; SEE=1.28) AFM (kg) = -4.716 + (0.142*Height²/Resistance) + (0.316*Weight) + (4.453*Sex) – (0.040*Reactance) (R²=0.73; SEE=1.54) GE Lunar (n=187): ASMM (kg) = 1.821 + (0.168*Height²/Resistance) + (0.132*Weight) –(1.931*Sex) + (0.017*Reactance) (R²=0.86; SEE=1.37) AFM (kg) = -6.553 + (0.093*Height²/Resistance) + (0.272*Weight) + (4.295*Sex) (R²=0.70; SEE=1.53) Sex: women=1, men=0 Previously published BIA-equations overestimated significantly ASMMHOLOGIC with mean biases of -0.36 kg and -1.05 kg. Conclusion: We propose new BIA equations for the accurate estimation of limb soft tissue masses in sarcopenic older adults. Users of both Hologic and GE Lunar may benefit from these equations in field research.
- Published
- 2015
193. Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus.
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Rodriguez‐Mañas, Leocadio, Laosa, Olga, Vellas, Bruno, Paolisso, Giuseppe, Topinkova, Eva, Oliva‐Moreno, Juan, Bourdel‐Marchasson, Isabelle, Izquierdo, Mikel, Hood, Kerry, Zeyfang, Andrej, Gambassi, Giovanni, Petrovic, Mirko, Hardman, Tim C., Kelson, Mark J., Bautmans, Ivan, Abellan, Gabor, Barbieri, Michelangela, Peña‐Longobardo, Luz M., Regueme, Sophie C., and Calvani, Riccardo
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TYPE 2 diabetes ,OLDER people ,AQUATIC exercises ,FUNCTIONAL loss in older people ,MULTIMODAL user interfaces ,BURDEN of care ,ISOMETRIC exercise - Abstract
Background: Type 2 diabetes, a highly prevalent chronic disease, is associated with increasing frailty and functional decline in older people. We aimed to evaluate the effectiveness of a multimodal intervention on functional performance in frail and pre‐frail participants aged ≥70 years with type 2 diabetes mellitus. Methods: The MID‐Frail study was a cluster‐randomized multicenter clinical trial conducted in 74 trial sites across seven European countries. The trial recruited 964 participants who were aged >70 years [mean age in intervention group, 78.4 (SD 5.6) years, 49.2% male and 77.6 (SD 5.29) years, 52.4% male in usual care group], with type diabetes mellitus and determined to be frail or pre‐frail using Fried's frailty phenotype. Participants were allocated by trial site to follow either usual care (UCG) or intervention procedures (IG). Intervention group participants received a multimodal intervention composed of (i) an individualized and progressive resistance exercise programme for 16 weeks; (ii) a structured diabetes and nutritional educational programme over seven sessions; and (iii) Investigator‐linked training to ensure optimal diabetes care. Short Physical Performance Battery (SPPB) scores were used to assess change in functional performance at 12 months between the groups. An analysis of the cost‐effectiveness of the intervention was undertaken using the incremental cost‐effectiveness ratio (ICER). Secondary outcomes included mortality, hospitalization, institutionalization, quality of life, burden on caregivers, the frequency and severity of hypoglycaemia episodes, and the cost‐effectiveness of the intervention. Results: After 12 months, IG participants had mean SPPB scores 0.85 points higher than those in the UCG (95% CI, 0.44 to 1.26, P < 0.0001). Dropouts were higher in frail participants and in the intervention group, but significant differences in SPPB between treatment groups remained consistent after sensitivity analysis. Estimates suggest a mean saving following intervention of 428.02 EUR (2016) per patient per year, with ICER analysis indicating a consistent benefit of the described health care intervention over usual care. No statistically significant differences between groups were detected in any of the other secondary outcomes. Conclusions: We have demonstrated that a 12 month structured multimodal intervention programme across several clinical settings in different European countries leads to a clinically relevant and cost‐effective improvement in the functional status of older frail and pre‐frail participants with type 2 diabetes mellitus. [ABSTRACT FROM AUTHOR]
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- 2019
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194. Assessment of Muscle Function and Physical Performance in Daily Clinical Practice : A position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).
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Beaudart, Charlotte, Rolland, Yves, Cruz-Jentoft, Alfonso J., Bauer, Jürgen M., Sieber, Cornel, Cooper, Cyrus, Al-Daghri, Nasser, Araujo de Carvalho, Islene, Bautmans, Ivan, Bernabei, Roberto, Bruyère, Olivier, Cesari, Matteo, Cherubini, Antonio, Dawson-Hughes, Bess, Kanis, John A., Kaufman, Jean-Marc, Landi, Francesco, Maggi, Stefania, McCloskey, Eugene, and Petermans, Jean
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FUNCTIONAL assessment ,MUSCLE strength ,MUSCLE weakness ,GRIP strength ,OSTEOARTHRITIS ,MUSCULOSKELETAL system - Abstract
It is well recognized that poor muscle function and poor physical performance are strong predictors of clinically relevant adverse events in older people. Given the large number of approaches to measure muscle function and physical performance, clinicians often struggle to choose a tool that is appropriate and validated for the population of older people they deal with. In this paper, an overview of different methods available and applicable in clinical settings is proposed. This paper is based on literature reviews performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) working group on frailty and sarcopenia. Face-to-face meetings were organized afterwards where the whole group could amend and discuss the recommendations further. Several characteristics should be considered when choosing a tool: (1) purpose of the assessment (intervention, screening, diagnosis); (2) patient characteristics (population, settings, functional ability, etc.); (3) psychometric properties of the tool (test-retest reliability, inter-rater reliability, responsiveness, floor and ceiling effects, etc.); (4) applicability of the tool in clinical settings (overall cost, time required for the examination, level of training, equipment, patient acceptance, etc.); (5) prognostic reliability for relevant clinical outcomes. Based on these criteria and the available evidence, the expert group advises the use of grip strength to measure muscle strength and the use of 4-m gait speed or the Short Physical Performance Battery test to measure physical performance in daily practice. The tools proposed are relevant for the assessment of muscle weakness and physical performance. Subjects with low values should receive additional diagnostic workups to achieve a full diagnosis of the underlying condition responsible (sarcopenia, frailty or other). [ABSTRACT FROM AUTHOR]
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- 2019
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195. Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study.
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Liberman, Keliane, Njemini, Rose, Luiking, Yvette, Forti, Louis N., Verlaan, Sjors, Bauer, Jürgen M., Memelink, Robert, Brandt, Kirsten, Donini, Lorenzo M., Maggio, Marcello, Mets, Tony, Wijers, Sander L. J., Sieber, Cornel, Cederholm, Tommy, and Bautmans, Ivan
- Abstract
Background: A chronic low-grade inflammatory profile (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for effects of nutritional supplementation on CLIP is limited. Aim: To investigate whether 13 weeks of nutritional supplementation of VitD and leucine-enriched whey protein affected CLIP in subjects enrolled in the PROVIDE-study, as a secondary analysis. Methods: Sarcopenic adults (low skeletal muscle mass) aged ≥ 65 years with mobility limitations (Short Physical Performance Battery 4–9) and a body mass index of 20–30 kg/m
2 were randomly allocated to two daily servings of active (n = 137, including 20 g of whey protein, 3 g of leucine and 800 IU VitD) or isocaloric control product (n = 151) for a double-blind period of 13 weeks. At baseline and after 13 weeks, circulating interleukin (IL)-8, IL-1 receptor antagonist (RA), soluble tumor-necrosis-factor receptor (sTNFR)1, IL-6, high-sensitivity C-reactive protein, pre-albumin and 25-hydroxyvitamin(OH)D were measured. Data-analysis included repeated measures analysis of covariance (corrected for dietary VitD intake) and linear regression. Results: IL-6 and IL-1Ra serum levels showed overall increases after 13 weeks (p = 0.006 and p < 0.001, respectively). For IL-6 a significant time × treatment interaction (p = 0.046) was observed, with no significant change over time in the active group (p = 0.155) compared to control (significant increase p = 0.012). IL-8 showed an overall significant decrease (p = 0.03). The change in pre-albumin was a significant predictor for changes in IL-6 after 13 weeks. Conclusions: We conclude that 13 weeks of nutritional supplementation with VitD and leucine-enriched whey protein may attenuate the progression of CLIP in older sarcopenic persons with mobility limitations. [ABSTRACT FROM AUTHOR]- Published
- 2019
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196. Association Between Immunosenescence Phenotypes and Pre-frailty in Older Subjects: Does Cytomegalovirus Play a Role?
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Dinh, Hung Cao, Bautmans, Ivan, Beyer, Ingo, Mets, Tony, Onyema, Oscar Okwudiri, Forti, Louis Nuvagah, Renmans, Wim, Meeren, Sam Vander, Jochmans, Kristin, Vermeiren, Sofie, Vella-Azzopardi, Roberta, Njemini, Rose, Cao Dinh, Hung, Vander Meeren, Sam, Azzopardi, Roberta Vella, and Gerontopole Brussels Study group
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IMMUNOSENESCENCE , *COMPARATIVE studies , *CYTOMEGALOVIRUS diseases , *CYTOMEGALOVIRUSES , *IMMUNOGLOBULINS , *INTERLEUKINS , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *PHENOTYPES , *EVALUATION research , *DISEASE prevalence , *DISEASE complications - Abstract
Frailty is highly prevalent in old age and confers an important mortality risk. Although the causes of frailty are multiple, immunosenescence (IS)-predominantly driven by cytomegalovirus (CMV)-has been implicated in its pathophysiology. Thus far, research examining the association between IS and frailty states is sparse and equivocal. On the other hand, evidence is mounting in support of the view that frailty can be reversed, especially for those in the pre-frail stage. Therefore, we aimed to clarify the impact of CMV on IS and its relevance to pre-frailty. One hundred seventy-three persons aged 80 to 99 years were enrolled. Pre-frailty was defined according to Fried's criteria. Anti-CMV IgG and serum IL-6 were measured using Architect iSystem and Luminex, respectively. T-cell phenotypes were determined using flow cytometry. The prevalence of pre-frailty was 52.6%, increased with age (p = .001), and was greater in men than women (p = .044). No relationship was found between pre-frailty and positive CMV serology. Further, CMV-seropositivity was significantly associated with less naïve cells, more memory and senescence-prone phenotypes (all p < .001). After adjusting for potential confounders, only IL-6, age and sex were predictive of pre-frailty. We conclude that the presence of pre-frailty is independent from CMV infection in very old subjects. [ABSTRACT FROM AUTHOR]
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- 2019
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197. Transfer factor, lung volumes, resistance and ventilation distribution in healthy adults
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Verbanck, Sylvia, Van Muylem, Alain, Schuermans, Daniel, Bautmans, Ivan, Thompson, Bruce B.R., Vincken, Walter, Verbanck, Sylvia, Van Muylem, Alain, Schuermans, Daniel, Bautmans, Ivan, Thompson, Bruce B.R., and Vincken, Walter
- Abstract
of lung function indices, including putative markers of small airway function, spanning a wide age range. We measured spirometry, transfer factor of the lung for carbon monoxide (TLCO), static lung volume, resistance and ventilation distribution in a healthy population, studying at least 20 subjects per sex and per decade between the ages of 20 and 80 years. With respect to the Global Lung Function Initiative reference data, our subjects had average z-scores for forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC of 0.12, 0.04 and 0.32, respectively. Reference equations were obtained which could account for a potential dependence of index variability on age and height. This was done for (but not limited to) indices that are pertinent to asthma and chronic obstructive pulmonary disease studies: forced expired volume in 6 s, forced expiratory flow, TLCO, specific airway conductance, residual volume (RV)/total lung capacity (TLC), and ventilation heterogeneity in acinar and conductive lung zones. Deterioration in acinar ventilation heterogeneity and lung clearance index with age were more marked beyond 60 years, and conductive ventilation heterogeneity showed the greatest increase in variability with age. The most clinically relevant deviation from published reference values concerned RV/TLC values, which were considerably smaller than American Thoracic Society/European Respiratory Society-endorsed reference values., SCOPUS: ar.j, info:eu-repo/semantics/published
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- 2016
198. Sex differences in self-perceived fatigue and handgrip performance and its relation with body composition in obese children
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Vantieghem, Stijn, Provyn, Steven, Tresignie, Jonathan, Bautmans, Ivan, Frailty in Ageing, Anatomy, and Experimental Anatomy
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handgrip performance ,OBESITY ,Body Composition ,self-perceived fatigue ,Adolescents - Abstract
Sex differences in self-perceived fatigue and handgrip performance and its relation with body composition in obese children Introduction: Maximal strength is an important factor to perform daily activities, especially in obese persons whose muscles must carry heavier loads, which can induce higher levels of fatigue. Weight excess consists mainly of fat mass but also lean mass which can influence the muscle performance positively in non-weight bearing activities. Studies correlating grip strength with segmental and total body composition (estimated using DXA) in obese children are scarce. This study explores the self-perceived fatigue, body composition and muscle performance in obese adolescents Methods: 117 obese children (70 girls and 47 boys) were examined for body composition (DXA), muscle performance (maximal grip strength, fatigue resistance and grip work) and self-perceived fatigue (Multidimensional Fatigue Inventory, MFI-20). Results: Girls showed no difference in absolute muscle performance compared with boys, even correction for lean arm mass. No significant difference was found between the 2 sexes for absolute fat mass, but girls showed significant lower lean mass and higher fat percentage than boys. Grip strength shows good correlations with lean and BMC in as well appendicular segments as total body composition and a negative correlation is found for fat% in both sexes. In boys fatigue parameters show correlation with body composition, not in girls. Conclusion: Based on our results we can state that self-perceived fatigue and handgrip performance has an influence on segmental and total body composition. Further studies are necessary to evaluate whether self-perceived fatigue is affected by weight loss and/or physical exercise interventions.
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- 2014
199. An in Vitro Comparison of DXA- And CT-derived leg composition in elderly persons
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Scafoglieri, Aldo, Deklerck, Rudi, Tresignie, Jonathan, Johan, De Mey, Clarys-Robion, Jan Pieter, Bautmans, Ivan, Manual Therapy, Frailty in Ageing, Experimental Anatomy, Supporting clinical sciences, Body Composition and Morphology, Medical Imaging, Translational Imaging Research Alliance, Radiology, Vriendenkring VUB, and Gerontology
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DXA ,tissues ,CT - Published
- 2014
200. Sarcopenia in daily practice: assessment and management
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Beaudart, Charlotte, primary, McCloskey, Eugène, additional, Bruyère, Olivier, additional, Cesari, Matteo, additional, Rolland, Yves, additional, Rizzoli, René, additional, Araujo de Carvalho, Islène, additional, Amuthavalli Thiyagarajan, Jotheeswaran, additional, Bautmans, Ivan, additional, Bertière, Marie-Claude, additional, Brandi, Maria Luisa, additional, Al-Daghri, Nasser M., additional, Burlet, Nansa, additional, Cavalier, Etienne, additional, Cerreta, Francesca, additional, Cherubini, Antonio, additional, Fielding, Roger, additional, Gielen, Evelien, additional, Landi, Francesco, additional, Petermans, Jean, additional, Reginster, Jean-Yves, additional, Visser, Marjolein, additional, Kanis, John, additional, and Cooper, Cyrus, additional
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- 2016
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