180 results on '"Baulig, Werner"'
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152. Continuous Elastomeric Pump-Based Ropivacaine Wound Instillation after Open Abdominal Aortic Surgery: How Reliable Is the Technique?
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Baulig, Werner, primary, Maurer, Konrad, additional, Theusinger, Oliver Michel, additional, Hinselmann, Valentin, additional, Baulig, Barbara, additional, Spahn, Donat Rudolph, additional, and Zalunardo, Marco Piero, additional
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- 2011
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153. P-16 - Regional cerebral oxygen desaturation measured by Near-Infrared-Spectroscopy is not a reliable indicator for cerebral outcome after aortic arch surgery
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Baulig, Werner, Buehler, Philipp, Brueckner, Karin, Bettex, Dominique, and Bosshart, Marco
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- 2015
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154. The PediaSat continuous central SvO2 monitoring system does not reliably indicate state or course of central venous oxygenation
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Baulig, Werner, primary, Béttex, Dominique, additional, Bürki, Christoph, additional, Schmitz, Achim, additional, Spielmann, Nelly, additional, Woitzek, Katja, additional, and Weiss, Markus, additional
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- 2010
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155. In-vitro evaluation of the PediaSat continuous central venous oxygenation monitoring system
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Baulig, Werner, primary, Spielmann, Nelly, additional, Zaiter, Hassan, additional, Lijovic, Tomislav, additional, Bettex, Dominique, additional, Bürki, Christoph, additional, and Weiss, Markus, additional
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- 2010
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156. In vitro factor XIII supplementation increases clot firmness in Rotation Thromboelastometry (ROTEM®)
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Asmis, Lars, primary, Seifert, Burkhardt, primary, Spahn, Donat, primary, Theusinger, Oliver, additional, and Baulig, Werner, additional
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- 2010
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157. Late pharmacologic conditioning with volatile anesthetics after cardiac surgery.
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Steurer, Marc P, Steurer, Martina A, Baulig, Werner, Piegeler, Tobias, Schläpfer, Martin, Spahn, Donat R, Falk, Volkmar, Dreessen, Pamela, Theusinger, Oliver M, Schmid, Edith R, Schwart, David, Neff, Thomas A, and Beck-Schimmer, Beatrice
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CARDIAC surgery ,CRITICAL care medicine ,INTENSIVE care units ,ANESTHESIA ,SEVOFLURANE ,CREATINE kinase - Abstract
Introduction: The aim of this randomized controlled trial was to investigate whether volatile anesthetics used for postoperative sedation have any beneficial effects on myocardial injury in cardiac surgery patients after on-pump valve replacement. Methods: Anesthesia was performed with propofol. After arrival in the intensive care unit (ICU), 117 patients were randomized to be sedated for at least 4 hours with either propofol or sevoflurane. Sevoflurane was administered by using the anesthetic-conserving device. Troponin T, creatine kinase, creatine kinase from heart muscle tissue, myoglobin, and oxygenation index were determined on arrival at the ICU, 4 hours after sedation, and in the morning of the first postoperative day (POD1). Primary end points were cardiac injury markers on POD1. As secondary end points oxygenation, postoperative pulmonary complications, and ICU and hospital stay were documented. Results: Fifty-six patients were analyzed in the propofol arm, and 46 patients in the sevoflurane arm. Treatment groups were comparable with regard to patient demographics and intraoperative characteristics. Concentration of troponin T as the most sensitive marker for myocardial injury at POD1 was significantly lower in the sevoflurane group compared with the propofol group (unadjusted difference, -0.4; 95% CI, -0.7 to -0.1; P < 0.01; adjusted difference, -0.2; 95% CI, -0.4 to -0.02; P = 0.03, respectively). Conclusions: The data presented in this investigation indicate that late postconditioning with the volatile anesthetic sevoflurane might mediate cardiac protection, even with a late, brief, and low-dose application. [ABSTRACT FROM AUTHOR]
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- 2012
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158. Off-pump surgery for the poor ventricle?
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Emmert, Maximilian, Salzberg, Sacha, Theusinger, Oliver, Rodriguez, Hector, Sündermann, Simon, Plass, Andre, Starck, Christoph, Seifert, Burkhardt, Baulig, Werner, Hoerstrup, Simon, Jacobs, Stephan, Grünenfelder, Jürg, and Falk, Volkmar
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CORONARY artery bypass ,HEART failure ,HEALTH outcome assessment ,CARDIAC surgery ,MYOCARDIAL revascularization ,LOGISTIC regression analysis ,KIDNEY failure - Abstract
Severely decreased ejection-fraction is an established risk-factor for worse outcome after cardiac surgery. We compare outcomes of off-pump coronary artery bypass grafting (OPCAB) and on-pump CABG (ONCABG) in patients with severely compromised EF. From 2004 to 2009, 478 patients with a decreased EF ≤35% underwent myocardial-revascularization. Patients received either OPCAB ( n = 256) or ONCABG ( n = 222). Propensity score (PS), including 50 preoperative risk-factors, was used to balance characteristics between groups. PS adjusted logistic regression analysis was performed to assess mortality and major adverse cardiac and cerebrovascular events (MACCE). A composite endpoint for major non-cardiac complications such as respiratory failure, renal failure, rethoracotomy was applied. Complete revascularization (CR) was assumed when the number of distal anastomoses was larger than that of diseased vessels. There was no difference for mortality (2.3 vs. 4.1%; PS-adjusted odds ratio (PS-OR) = 1.05; p = 0.93) and MACCE (13.7 vs. 17.6%; PS-OR = 1.22; p = 0.50) including myocardial-infarction (1.4 vs. 4.9%; PS-OR = 0.39; p = 0.26), low cardiac output (2.3 vs. 4.7%; PS-OR = 0.75; p = 0.72) and stroke (2.3 vs. 2.7%; PS-OR = 0.69; p = 0.66). OPCAB patients presented with a trend to less frequent occurrence of the non-cardiac composite (12.1 vs. 22.1%; PS-OR = 0.54; p = 0.059) including renal dysfunction (PAOR = 0.77; 95% CI 0.31-1.9; p = 0.57), bleeding (PAOR = 0.42; 95% CI 0.14-1.20; p = 0.10) and respiratory failure (PAOR = 0.39; 95% CI 0.05-3.29; p = 0.39). The rate of complete revascularization was similar (92.2 vs. 92.8%; PS-OR = 0.75; p = 0.50). OPCAB in patients with severely decreased EF is safe and feasible. It may even benefit these patients in regard to non-cardiac complications and does not come at cost of less complete revascularization. [ABSTRACT FROM AUTHOR]
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- 2012
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159. The Revised Digital Transcutaneous PCO2/SpO2 Ear Sensor Is a Reliable Noninvasive Monitoring Tool in Patients After Cardiac Surgery.
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Roediger, Regine, Beck-Schimmer, Beatrice, Theusinger, Oliver M., Rusch, Denise, Seifert, Burkhardt, Spahn, Donat R., Schmid, Edith R., and Baulig, Werner
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CARDIAC surgery ,HEART beat ,PULSE oximeters ,CARBON dioxide in the body ,ELECTROCARDIOGRAPHY ,INTENSIVE care units - Abstract
Objective: The aim of this study was to validate the revised SenTec V-Sign 2 sensor (SenTec AG, Therwil, Switzerland) for combined noninvasive continuous assessment of pulse rate, pulse oximetry (SpO
2 ), and transcutaneous carbon dioxide tension (PtcCO2 ) in adults after cardiac surgery. Design: A prospective clinical study. Setting: A single-center university hospital. Participants: Twenty adult patients aged 36 to 84 years after cardiac surgery. Interventions: SpO2 and PtcCO2 values of three V-Sign 2 sensors (SenTec AG) attached at the earlobe, forehead, and cheek and SpO2 values of the Nellcor Durasensor (Model DS-100A; Nellcor Puritan Bennett Inc, Pleasanton, CA) were compared with simultaneous measurements of blood gases and end-expiratory carbon dioxide. Measurements and Main Results: Measurements were performed during periods of hyper-, normo-, and hypocapnia and then at 30-minute intervals up to 5 hours. Bland-Altman analysis and simple regression analysis were used. Results: The detection failures for PtcCO2 were 0.3% to 1.3%, for SpO2 10% to 25%, and for pulse rate 5% to 10%. The V-Sign 2 earlobe sensor provided the best results. The mean bias and limits of agreement for PtcCO2ear and PaCO2 were 1.1 and −3.4/+5.5 mmHg. The drift of PtcCO2 was negligible at all locations. The mean bias and limits of agreement of V-Sign SpO2ear and SaO2 , as well as V-Sign pulse rate and the electrocardiogram, were −1.7% and −6.8/+3.9% and 1.2 beats/min and −3.3/+5.8 beats/min. End-expiratory carbon dioxide showed a weak correlation with PaCO2 (r2 = 0.47). Conclusions: Transcutaneous capnometry using the revised V-Sign 2 sensor at the earlobe is a reliable monitoring tool during the recovery period of patients after cardiac surgery. This approach has the potential to reduce the number of arterial blood gas samples. [Copyright &y& Elsevier]- Published
- 2011
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160. Comparison of Spectral Entropy and Bispectral Index Electroencephalography in Coronary Artery Bypass Graft Surgery.
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Baulig, Werner, Seifert, Burkhardt, Schmid, Edith R., and Schwarz, Urs
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ELECTROENCEPHALOGRAPHY ,CORONARY artery bypass ,COMPARATIVE studies ,ANESTHESIA ,CARDIAC surgery patients ,MEDICAL statistics - Abstract
Objective: The study''s aim was to compare response entropy (RE) and state entropy (SE) with bispectral index (BIS) electroencephalography (EEG) as an alternative cerebral monitoring tool in patients scheduled for coronary artery bypass graft surgery. Design: Prospective, observational single-center study. Setting: University hospital. Participants: Thirty patients undergoing coronary artery bypass graft surgery receiving remifentanil-propofol anesthesia. Interventions: Surgery was performed with cardiopulmonary bypass (CPB) and cardiac arrest in 15 patients, with CPB without cardiac arrest in 9 patients and without CPB in 6 patients. Measurements and Main Results: RE, SE, BIS, burst suppression ratio (BSR), and frontal electromyography (f-EMG) were detected simultaneously. RE and SE compared favorably with BIS and their correlations were strong (r
2 = 0.6, r2 = 0.55, respectively). The mean bias of RE and BIS was −1.8, but limits of agreement were high (+20.5/−24.1). RE and SE tended to be lower than the BIS values in the CPB subgroups. The detection of BSR was similar with RE and SE and the BIS. A strong correlation existed between BIS and f-EMG (r2 = 0.62) in contrast to RE (r2 = 0.45) and SE (r2 =0.39). BIS monitoring was significantly more disturbed than RE and SE with 9.1% ±10.9% and 0.1% ± 0.2% of the total anesthesia time, respectively. Neither implicit nor explicit memory was shown. Conclusion: RE and SE are comparable with the BIS but showed significantly less interference from f-EMG and superior resistance against artifacts. Thus, spectral entropy is more suitable than the BIS during propofol-remifentanil anesthesia in cardiac surgery patients. [Copyright &y& Elsevier]- Published
- 2010
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161. Accuracy of continuous central venous oxygen saturation monitoring in patients undergoing cardiac surgery.
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Baulig W, Dullenkopf A, Kobler A, Baulig B, Roth HR, Schmid ER, Baulig, Werner, Dullenkopf, Alexander, Kobler, Andreas, Baulig, Barbara, Roth, Hans Rudolf, and Schmid, Edith R
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Objective: Continuous assessment of central venous oxygen saturation (S(cevox)O(2)) with the CeVOX device (Pulsion Medical Systems, Munich, Germany) was evaluated against central venous oxygen saturation (S(cv)O(2)) determined by co-oximetry.Methods: In 20 cardiac surgical patients, a CeVOX fiberoptic probe was introduced into a standard central venous catheter placed in the right internal jugular vein and advanced 2-3 cm beyond the catheter tip. After in vivo calibration of the probe, S(cevox)O(2), S(cv)O(2), mixed venous oxygen saturation (S(mv)O(2)) haemoglobin (Hb), body temperature, heart rate, central venous and mean arterial pressure, and cardiac index were assessed simultaneously at 30 min intervals during surgery and at 60 min intervals during recovery in the intensive care unit. Agreement between S(cevox)O(2), and S(cv)O(2) was determined by Bland-Altman analysis. Simple regression analysis was used to assess the correlation of S(cevox)O(2), and S(cv)O(2) to Hb, body temperature and haemodynamic parameters.Results: Values of S(cevox)O(2) and S(cv)O(2) (84 data pairs during surgery and 106 in the intensive care unit) ranged between 45-89% and 43-90%, respectively. Mean bias and limits of agreement of S(cevox)O(2) and S(cv)O(2) were -0.9 (-7.9/+6.1)% during surgery and -1.2 (-10.5/+8.1)% in the intensive care unit. In 37.9% of all measured data pairs, the difference between S(cevox)O(2) and S(cv)O(2) was beyond clinically acceptable limits (> or =1 s.d.). Mean bias was significantly influenced by cardiac index. Sensitivity and specificity of S(cevox)O(2) to detect substantial (> or =1 s.d.) changes in S(cv)O(2) were 89 and 82%, respectively.Conclusions: In adult patients during and after cardiac surgery, the current version of the CeVOX device might not be the tool to replace S(cv)O(2) determined by co-oxymetry, although sensitivity and specificity of S(cevox)O(2 )to predict substantial changes in S(cv)O(2) were acceptable. [ABSTRACT FROM AUTHOR]- Published
- 2008
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162. CLINICAL VALIDATION OF A DIGITAL TRANSCUTANEOUS PCO2/SPO2 EAR SENSOR IN ADULT PATIENTS AFTER CARDIAC SURGERY.
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Baulig, Werner, Schütt, Philipp, Roth, Hans R., Hayoz, Josef, and Schmid, Edith R.
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Abstract Objective The aim of this study was to validate the V-Sign digital sensor (SenTec AG, Therweil, Switzerland) for combined noninvasive assessment of pulse oxymetric oxygen saturation (SpO2) and transcutaneous carbon dioxide tension (PtcCO2) in adults after cardiac surgery. Methods In twenty one patients, aged 51–86 years, simultaneous measurements of blood gases with the V-Sign Sensor and with two Nellcor Durasensors (model DS-100A), one at the opposite earlobe and one with a finger clip, were compared first during hyper-, normo- and hypocapnia and at different pulse rates using a pacemaker, and then at 2-h intervals up to 8 h. Agreement was assessed by Bland-Altman analysis. Results PtcCO2 data of three patients were excluded because of calibration failure of the device. Median (range) PtcCO2 for the remaining patients was 5.49 (3.3–7.6) kPa and arterial carbon dioxide tension (PaCO2) was 5.43 (3.61–7.41) kPa. Corresponding mean bias was +0.05 kPa and limits of agreement (LOA) were −1.2/+1.3 kPa. During normo- and hypoventilation, mean bias was good at +0.02 and +0.04 kPa respectively, but limits of agreement were poor at −0.67/+0.69 and −0.81/+0.88 kPa. In 10 patients, an initial overshoot of PtcCO2 was observed. Mean bias of SpO2 and pulse rate was close to zero (−1.5% and +0.001 bpm respectively), but limits of agreement were unacceptably high (−21.4/+18.4% and −22.3/+22.3 bpm). Conclusions In the present state of development the SenTeC Digital monitor V-Sign device has serious limitations. Additional efforts are necessary to eliminate calibration failures and the initial overshoot of PtcCO2 as well as to improve detection of SpO2 and pulse rate. [ABSTRACT FROM AUTHOR]
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- 2007
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163. Cerebral Near-Infrared Spectroscopy in Adult Patients After Cardiac Surgery Is Not Useful for Monitoring Absolute Values But May Reflect Trends in Venous Oxygenation Under Clinical Conditions.
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Dullenkopf, Alexander, Baulig, Werner, Weiss, Markus, and Schmid, Edith R.
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SPECTRUM analysis ,CARDIAC surgery ,HYPERBARIC oxygenation ,PULMONARY artery - Abstract
Objective: Cerebral near-infrared spectroscopy (NIRS) was evaluated for use in monitoring global oxygenation in adult patients after cardiac surgery. Design: Prospective, randomized clinical monitoring study. Setting: Intensive care unit for cardiac surgery; university hospital. Participants: The study included 35 patients scheduled for cardiac surgery with insertion of a pulmonary artery catheter; patients with known cerebral-vascular perfusion disturbances were excluded. Interventions: Noninvasive cerebral NIRS oxygen saturation (rSO
2 ) and conventional intensive care monitoring parameters were assessed. Measurements and Main Results: Simple regression analysis was used to assess the correlation of rSO2 to hemodynamic parameters. There was fair-to-moderate intersubject correlation to hemoglobin concentration (r = 0.45, p < 0.0001) and mixed venous oxygen saturation (SmvO2 ) (r = 0.33, p < 0.0001). Sensitivity and specificity of rSO2 to detect substantial (≥1 standard deviation) changes in mixed venous oxygen saturation were 94% and 81%, respectively. Conclusions: Cerebral NIRS in adult patients might not be the tool to replace mixed venous oxygen monitoring. Further work has to be done to assess its potential to reflect intraindividual trends. [Copyright &y& Elsevier]- Published
- 2007
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164. ACCURACY OF A NOVEL APPROACH TO MEASURING ARTERIAL THERMODILUTION CARDIAC OUTPUT DURING INTRA-AORTIC COUNTERPULSATION.
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Baulig, Werner, Schuett, Philipp, Goedje, Oliver, and Schmid, Edith R.
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Objective. To assess the agreement between a novel approach of arterial and the pulmonary artery bolus thermodilution for measuring cardiac output in critically ill patients during aortic counterpulsation. Methods. Eighteen male patients aged 37-80 years, undergoing preoperative insertion of an intra-aortic balloon pump (IABP) and elective coronary artery bypass grafting. A thin 1.3FG thermistor was introduced through the pressure lumen to the tip of an 8FG IABP catheter, and the pump rate was set at 1:1. After arrival in the intensive care unit cardiac output (CO) was measured under haemodynamic steady-state conditions hourly for 8-11 h, and arterial bolus thermodilution (BCO
iabp ) and pulmonary artery bolus thermodilution (BCOpulm ) were determined after the patients' admission to the intensive care unit. Results. A total of 198 data pairs were obtained: 177 with aortic counterpulsation and 21 without. During aortic counterpulsation, median CO was 6.8 l/min for BCOiabp and 6.1 l/min for BCOpulm , without aortic counterpulsation; corresponding values were 7.1 l/min for BCOiabp and 6.5 l/min for BCOpulm with aortic counterpulsation. Mean bias was +0.77 l/min, limits of agreement (± 2 SD) were −1.27/+2.81 l/min, and mean error (2 SD/[(BCOiabp + BCOpulm )/2] was 31.4%. Without aortic counterpulsation, corresponding values were +0.43 l/min, − 1.03/+1.87 l/min, and 22.4%. Conclusions. Agreement between BCOiabp and BCOpulm was satisfactory for CO values between 2.0 and 10 l/min only without aortic counterpulsation. BCOiabp CO measurements during aortic counterpulsation after coronary artery bypass grafting cannot be recommended at the present time. [ABSTRACT FROM AUTHOR]- Published
- 2007
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165. Laryngeal damage due to an unexpectedly large and inappropriately designed cuffed pediatric tracheal tube in a 13-month-old child.
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Dillier, Claudia, Trachsel, Daniel, Baulig, Werner, Gysin, Claudine, Gerber, Andreas, and Weiss, Markus
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Copyright of Canadian Journal of Anaesthesia / Journal Canadien d'Anesthésie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2004
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166. In vitro factor XIII supplementation increases clot firmness in Rotation Thromboelastometry (ROTEM®)
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Theusinger, Oliver M., Baulig, Werner, Asmis, Lars M., Seifert, Burkhardt, and Spahn, Donat R.
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- 2010
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167. Impact of city police layperson education and equipment with automatic external defibrillators on patient outcome after out of hospital cardiac arrest.
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Stein, Philipp, Spahn, Gabriela H., Müller, Stefan, Zollinger, Andreas, Baulig, Werner, Brüesch, Martin, Seifert, Burkhardt, and Spahn, Donat R.
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LAYPERSONS , *AUTOMATED external defibrillation , *ELECTRIC countershock , *HEALTH outcome assessment , *BRAIN function localization , *POLICE education , *CARDIOPULMONARY resuscitation , *DEFIBRILLATORS , *EMERGENCY medical services , *HOSPITAL care , *MEDICAL care , *PATIENTS , *POLICE , *TREATMENT effectiveness , *RETROSPECTIVE studies - Abstract
Introduction: Out of hospital cardiac arrest (OHCA) occurs frequently and the outcome is often dismal. Early defibrillation saves lives and brain function in OHCA. The Zurich city police (STAPO) forces were instructed and equipped to provide basic life support (BLS) and to use an AED in 2009.Methods: Retrospective observational study comparing period 1 (P1) 2004-2009 before equipping and training of the STAPO and period 2 (P2) 2010-2015 after the implementation. Patients suffering from OHCA of cardiac or presumed cardiac origin in the city of Zurich undergoing CPR by EMS in P1 (n=709) and P2 (n=684) were included. Intervention periods and outcome were compared between the periods. Outcome variables were adjusted for patient age and gender, witnessed status, and defibrillation by the EMS, STAPO, layperson or no defibrillation.Results: In P2, CPR was started by the STAPO in a median of 8 (IQR 6-9) minutes after the arrest and thus significantly earlier (median 3min) than by the EMS (p<0.001). STAPO performed the first defibrillation in a median of 9 (IQR 8-10) minutes and thus significantly earlier (median 6min) than the EMS (p<0.001). Outcome improved significantly in P2: proportion of patients with return of spontaneous circulation (ROSC, P2 35.8%, P1 24.0%, OR 1.8, 95% CI 1.4-2.2, p<0.001), hospital admission (P2 32.2%, P1 21.4%, OR 1.7, 95% CI 1.4-2.2, p<0.001) and survival to hospital discharge (P2 13.6%, P1 6.9%, OR 2.1 95% CI 1.5-3.0, p<0.001). If the patient was firstly defibrillated by the STAPO, ROSC (STAPO 74.4%, adj. OR 2.6, 95% CI 1.3-5.4, p=0.010) and hospital admission (STAPO 72.1%, adj. OR 2.8, 95% CI 1.4-5.6, p=0.005) was higher compared to patients firstly defibrillated by the EMS. Survival to hospital discharge (STAPO 30.2%, adj. OR 1.4, 95% CI 0.7-2.9, p=0.38) was unchanged.Conclusion: Dispatching BLS trained and AED equipped police forces results in earlier and more successful resuscitation of OHCA victims, leading to higher proportions of patients with ROSC, hospital admission and survival to hospital discharge. [ABSTRACT FROM AUTHOR]- Published
- 2017
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168. Comparison of the resonance sonorheometry based Quantra® system with rotational thromboelastometry ROTEM® sigma in cardiac surgery – a prospective observational study
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Stefanie von Felten, Michael T. Ganter, Werner Baulig, Samira Akbas, Wolfgang Keul, Pascal Berdat, Marija Jovic, Oliver M. Theusinger, Philipp K. Schütt, Klaus Steigmiller, University of Zurich, and Baulig, Werner
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Male ,medicine.medical_specialty ,10216 Institute of Anesthesiology ,610 Medicine & health ,Resonance Sonorheometry ,Anesthesiology ,Monitoring, Intraoperative ,Humans ,Medicine ,Ultrasonics ,RD78.3-87.3 ,Prospective Studies ,Cardiac Surgical Procedures ,Bland–Altman plot ,Blood Coagulation ,Aged ,Viscoelastic testing ,business.industry ,Research ,Elasticity ,Thrombelastography ,Cardiac surgery ,Thromboelastometry ,Anesthesiology and Pain Medicine ,Median time ,Quantra ,Female ,2703 Anesthesiology and Pain Medicine ,Rheology ,business ,Nuclear medicine ,ROTEM sigma, cardiac surgery ,Heparin neutralization - Abstract
Background Measures of the sonorheometry based Quantra® viscoelastic hemostatic analyzer (HemoSonics, LCC, Charlottesville, VA, USA) were compared with corresponding results of the ROTEM® sigma device (Instrumentation Laboratory, Bedford, MA, USA). Methods In thirty-eight patients scheduled for elective cardiac surgery between December 2018 and October 2019, blood samples were taken after induction of anesthesia (sample 1) and after heparin neutralization (sample 2) and measured on Quantra (QPlus® Cartridge) and ROTEM sigma (ROTEM® sigma complete + hep Cartridge). Clot times and clot stiffness values were recorded. Clot stiffness values of ROTEM amplitudes (A in mm) were converted to shear modulus (G) in hectoPascal (hPa): G (hPa) = (5 x A)/(100-A). Additionally, time-to-results was recorded. Spearman rank test correlation and Bland Altman analysis were performed. Results Clot stiffness parameters of the Quantra correlated strongly with corresponding measurements of the ROTEM with r = 0.93 and 0.94 for EXTEM A10 vs CS and r = 0.94 and 0.96 for FIBTEM A10 vs FCS for sample 1 and 2, respectively. Quantra clot time correlated strongly with ROTEM INTEM CT with r = 0.71 for sample 1 and r = 0.75 for sample 2. However, Bland Altman analysis showed no agreement in all compared assays of both methods. The median time to delivery of first and complete results was significantly shorter for Quantra (412 and 658 s) compared to ROTEM sigma (839 and 1290 s). Conclusions The Quantra showed a strong correlation with the ROTEM sigma for determining clot times and clot stiffness and the parameters assess similar aspects of clot development. However, these parameters are not directly interchangeable and implicate that separate cut-off values need to be established for users of the Quantra device. Word count: 278. Trial registration The study was retrospectively registered with ClinicalTrials.gov (ID: NCT04210830) at December 20th 2019.
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- 2021
169. Accuracy of non-invasive continuous total hemoglobin measurement by Pulse CO-Oximetry in severe traumatized and surgical bleeding patients
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Burkhardt Seifert, Donat R. Spahn, Oliver M. Theusinger, Werner Baulig, University of Zurich, and Baulig, Werner
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Adult ,Male ,Severe bleeding ,medicine.medical_specialty ,Post hoc ,10216 Institute of Anesthesiology ,Blood Loss, Surgical ,Hemorrhage ,Health Informatics ,610 Medicine & health ,Critical Care and Intensive Care Medicine ,Hemoglobins ,03 medical and health sciences ,Patient Admission ,0302 clinical medicine ,030202 anesthesiology ,Monitoring, Intraoperative ,Linear regression ,medicine ,Humans ,Oximetry ,Prospective Studies ,Hemoglobin measurement ,Aged ,Monitoring, Physiologic ,2718 Health Informatics ,Pulse (signal processing) ,business.industry ,Non invasive ,Reproducibility of Results ,030208 emergency & critical care medicine ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,Middle Aged ,Predictive value ,Total hemoglobin ,Surgery ,Anesthesiology and Pain Medicine ,Sample Size ,Anesthesia ,Emergency Medicine ,Hemoglobinometry ,Linear Models ,Female ,2703 Anesthesiology and Pain Medicine ,business ,2706 Critical Care and Intensive Care Medicine ,Algorithms - Abstract
The Masimo Radical-7 Pulse CO-Oximeter (Masimo Corp., USA) non-invasively computes hemoglobin concentration (SpHb). SpHb was compared to Co-Oximeter readings (CoOxHb) of arterial samples in surgery patients of the emergency department. Forty-six patients were enrolled. The Masimo R1 25L (revision F and G) adult adhesive sensor was attached to the ring finger of the arterially cannulated hand. Before start, every 30 min during surgery and in the case of severe bleeding SpHb and CoOxHb values were documented. SpHb and post hoc adjusted SpHb (AdSpHb) values were analyzed. Linear regression analysis and Bland-Altman plot for agreement were performed. The detection failure rate of SpHb was 24.5 %. CoOxHb and SpHb showed a strong correlation (r = +0.81), but agreement was moderate [bias (LOA) of -0.6 (-3.0; +1.9)] g/dl. Positive and negative predicted value was 0.49 and 0.69. Exclusion of changes of CoOxHb values ≤1 g/dl resulted in a positive and negative predictive value of 0.66 and 1.00. Post hoc adjustment of the SpHb (AdSpHb) improved linear correlation of CoOxHb and AdSpHb [r = +0.90 (p
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- 2017
170. Short term general anesthesia for retro-bulbar block in ophthalmic surgery generates no significant hypercapnia
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Monica Weber, Werner Baulig, Oliver M. Theusinger, Beatrice Beck-Schimmer, Peter Biro, University of Zurich, and Baulig, Werner
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Male ,medicine.medical_specialty ,10216 Institute of Anesthesiology ,Apnea ,610 Medicine & health ,Health Informatics ,Ophthalmologic Surgical Procedures ,Richmond Agitation-Sedation Scale ,Anesthesia, General ,Critical Care and Intensive Care Medicine ,Hypercapnia ,03 medical and health sciences ,0302 clinical medicine ,Bolus (medicine) ,Transcutaneous carbon dioxide tension ,030202 anesthesiology ,Anesthesiology ,Medicine ,Humans ,Thiopental ,2718 Health Informatics ,Ophthalmic surgery ,Aged ,business.industry ,Equipment Design ,Carbon Dioxide ,Middle Aged ,Respiration, Artificial ,Chin ,Surgery ,Oxygen ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,030228 respiratory system ,Anesthesia ,Female ,2703 Anesthesiology and Pain Medicine ,medicine.symptom ,Blood Gas Analysis ,2706 Critical Care and Intensive Care Medicine ,business - Abstract
To assess the impact of short time hypnosis for retro-bulbar anesthesia on ventilation in patients undergoing ophthalmic surgery of the anterior eye chamber. In all patients, a combined continuous transcutaneous carbon dioxide tension (PtcCO2) and partial oxygen saturation (SpO2) measurement was applied in addition to routine monitoring. To enable unconscious application of retro-bulbar anesthesia, intravenous thiopental was given in one to multiple bolus doses. Transient breathing support included chin lift, Esmarch maneuver and manual hand-bag ventilation via face mask. Main endpoints were apnea time, recovery time according to the Richmond Agitation Sedation Scale, as well as SpO2 and PtcCO2 readings at predefined time points. Fifty-two patients with a mean age of 68 ± 13 years were included. Average thiopental dose was 2.7 ± 0.6 mg/kg. In seven (13.5%) patients repeated doses of thiopental were necessary to a total of 3.3 ± 1.1 mg/kg. Except one patient, no severe, significant or clinical relevant hypercapnia or desaturation periods were observed, and the occurring elevation of PtcCO2 values did not correlate with the application of repeated doses of thiopental or the need for the Esmarch maneuver. Higher PtcCO2 values were associated with the presence of hypertension and smoking. Apnea (p
- Published
- 2016
171. Transcutaneous continuous carbon dioxide tension monitoring reduced incidence, degree and duration of hypercapnia during combined regional anaesthesia and monitored anaesthesia care in shoulder surgery patients
- Author
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Alain Borgeat, José Aguirre, Sandra Guzzella, Marija Keselj, Barbara Baulig, Werner Baulig, University of Zurich, and Baulig, Werner
- Subjects
Adult ,Male ,Shoulder ,Shoulder surgery ,medicine.medical_treatment ,Remifentanil ,610 Medicine & health ,Health Informatics ,Critical Care and Intensive Care Medicine ,Sensitivity and Specificity ,142-005 142-005 ,MAC Regimen ,Hypercapnia ,Piperidines ,Anesthesia, Conduction ,Monitoring, Intraoperative ,Humans ,Medicine ,Prospective Studies ,Propofol ,Monitoring, Physiologic ,2718 Health Informatics ,business.industry ,Incidence ,Reproducibility of Results ,Oxygenation ,Carbon Dioxide ,Middle Aged ,respiratory tract diseases ,Hypoventilation ,Oxygen ,Anesthesiology and Pain Medicine ,Anesthesia ,Breathing ,Female ,2703 Anesthesiology and Pain Medicine ,medicine.symptom ,business ,2706 Critical Care and Intensive Care Medicine ,Blood Gas Monitoring, Transcutaneous ,Anesthetics, Intravenous ,medicine.drug - Abstract
We studied the impact of transcutaneous continuous carbon dioxide tension (PtcCO2) monitoring on ventilation and oxygenation during monitored anaesthesia care (MAC) in patients scheduled for shoulder surgery with continuous interscalene block. 50 patients were randomised either to the intervention (I-group) or the control (C-group) group. In both groups MAC was performed using target controlled infusion of propofol and remifentanil. MAC regimen was adapted to PtcCO2 values in the I-group, whereas the C-group was blinded for these values. Primary outcome was the incidence, degree and duration of hypoventilation stages. In the I-group and the C-group the mean ± SD [range] of PtcCO2 and PaCO2 was 5.79 ± 0.84 [4.37] and 5.44 ± 0.59 [2.78] kPa, as well as 6.41 ± 1.17 [6.29] and 6.01 ± 0.96 [7.15] kPa. Periods of PtcCO2/PaCO2 > 6.5 kPa were 21.0 ± 35.7/1.2 ± 4.2 min in the I-group and 45.6 ± 40.0/18.6 ± 26.8 min in the C-group. Severe hypercapnia (PtcCO2 and/or PaCO2 > 7.5 kPa) was dected in 3/0 patients of the I-group and in 10/3 patients of the C-group. PtcCO2 and PaCO2 showed a strong correlation (r = 0.78), but only moderate agreement with a mean bias (LOA) of −0.37 (−1.69; +0.95) kPa showing an overestimation of the PaCO2. Sensitivity and specificity of PtcCO2 to detect changes of PaCO2 was 0.94 and 0.56, respectively. In no patient SpO2 or SaO2 values lower than 90 % were measured. Despite a moderate agreement between PaCO2 and PtcCO2 the PtcCO2 monitoring significantly reduced incidence, degree and duration of hypercapnia in shoulder surgery patients with MAC.
- Published
- 2015
172. Accuracy of a novel approach to measuring arterial thermodilution cardiac output during intra-aortic counterpulsation
- Author
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Werner Baulig, Edith R. Schmid, Philipp Schuett, Oliver Goedje, University of Zurich, and Baulig, Werner
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cardiac output ,Thermodilution ,Hemodynamics ,Health Informatics ,610 Medicine & health ,Critical Care and Intensive Care Medicine ,142-005 142-005 ,Bolus (medicine) ,Counterpulsation ,Intensive care ,Internal medicine ,medicine.artery ,medicine ,Humans ,Cardiac Output ,Aorta ,Aged ,Monitoring, Physiologic ,2718 Health Informatics ,Aged, 80 and over ,business.industry ,Temperature ,Reproducibility of Results ,Carbon Dioxide ,Middle Aged ,Intensive Care Units ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Circulatory system ,Pulmonary artery ,Cardiology ,2703 Anesthesiology and Pain Medicine ,business ,2706 Critical Care and Intensive Care Medicine ,Artery - Abstract
Objective: To assess the agreement between a novel approach of arterial and the pulmonary artery bolus thermodilution for measuring cardiac output in critically ill patients during aortic counterpulsation. Methods: Eighteen male patients aged 37-80years, undergoing preoperative insertion of an intra-aortic balloon pump (IABP) and elective coronary artery bypass grafting. A thin 1.3FG thermistor was introduced through the pressure lumen to the tip of an 8FG IABP catheter, and the pump rate was set at 1:1. After arrival in the intensive care unit cardiac output (CO) was measured under haemodynamic steady-state conditions hourly for 8-11h, and arterial bolus thermodilution (BCOiabp) and pulmonary artery bolus thermodilution (BCOpulm) were determined after the patients' admission to the intensive care unit. Results: A total of 198 data pairs were obtained: 177 with aortic counterpulsation and 21 without. During aortic counterpulsation, median CO was 6.8l/min for BCOiabp and 6.1l/min for BCOpulm, without aortic counterpulsation; corresponding values were 7.1l/min for BCOiabp and 6.5l/min for BCOpulm with aortic counterpulsation. Mean bias was +0.77l/min, limits of agreement ( ± 2SD) were -1.27/+2.81l/min, and mean error (2SD/[(BCOiabp+BCOpulm)/2] was 31.4%. Without aortic counterpulsation, corresponding values were +0.43l/min, -1.03/+1.87l/min, and 22.4%. Conclusions: Agreement between BCOiabp and BCOpulm was satisfactory for CO values between 2.0 and 10l/min only without aortic counterpulsation. BCOiabp CO measurements during aortic counterpulsation after coronary artery bypass grafting cannot be recommended at the present time
- Published
- 2007
173. Clinical validation of a digital transcutaneous PCO2/SpO2 ear sensor in adult patients after cardiac surgery
- Author
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Werner Baulig, Hans Rudolf Roth, Edith R. Schmid, Josef Hayoz, Philipp K. Schütt, University of Zurich, and Baulig, Werner
- Subjects
Male ,medicine.medical_specialty ,610 Medicine & health ,Health Informatics ,Critical Care and Intensive Care Medicine ,142-005 142-005 ,Fingers ,Hypocapnia ,Bias ,Intensive care ,Internal medicine ,medicine ,Humans ,Cardiac Surgical Procedures ,Earlobe ,2718 Health Informatics ,Oxygen saturation (medicine) ,Aged ,Aged, 80 and over ,Adult patients ,Pulse (signal processing) ,business.industry ,Ear ,Carbon Dioxide ,Middle Aged ,medicine.disease ,Cardiac surgery ,Hypoventilation ,Oxygen ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Anesthesia ,Cardiology ,Female ,2703 Anesthesiology and Pain Medicine ,medicine.symptom ,2706 Critical Care and Intensive Care Medicine ,business ,Blood Gas Monitoring, Transcutaneous - Abstract
Objective: The aim of this study was to validate the V-Sign digital sensor (SenTec AG, Therweil, Switzerland) for combined noninvasive assessment of pulse oxymetric oxygen saturation (SpO2) and transcutaneous carbon dioxide tension (PtcCO2) in adults after cardiac surgery. Methods: In twenty one patients, aged 51-86years, simultaneous measurements of blood gases with the V-Sign Sensor and with two Nellcor Durasensors (model DS-100A), one at the opposite earlobe and one with a finger clip, were compared first during hyper-, normo- and hypocapnia and at different pulse rates using a pacemaker, and then at 2-h intervals up to 8h. Agreement was assessed by Bland-Altman analysis. Results: PtcCO2 data of three patients were excluded because of calibration failure of the device. Median (range) PtcCO2 for the remaining patients was 5.49 (3.3-7.6) kPa and arterial carbon dioxide tension (PaCO2) was 5.43 (3.61-7.41) kPa. Corresponding mean bias was +0.05kPa and limits of agreement (LOA) were −1.2/+1.3kPa. During normo- and hypoventilation, mean bias was good at +0.02 and +0.04kPa respectively, but limits of agreement were poor at −0.67/+0.69 and −0.81/+0.88kPa. In 10 patients, an initial overshoot of PtcCO2 was observed. Mean bias of SpO2 and pulse rate was close to zero (−1.5% and +0.001bpm respectively), but limits of agreement were unacceptably high (−21.4/+18.4% and −22.3/+22.3bpm). Conclusions: In the present state of development the SenTeC Digital monitor V-Sign device has serious limitations. Additional efforts are necessary to eliminate calibration failures and the initial overshoot of PtcCO2 as well as to improve detection of SpO2 and pulse rate
- Published
- 2007
174. Comparison of the resonance sonorheometry based Quantra® system with rotational thromboelastometry ROTEM® sigma in cardiac surgery - a prospective observational study.
- Author
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Baulig W, Akbas S, Schütt PK, Keul W, Jovic M, Berdat P, von Felten S, Steigmiller K, Ganter MT, and Theusinger OM
- Subjects
- Aged, Elasticity, Female, Humans, Male, Prospective Studies, Rheology instrumentation, Blood Coagulation, Cardiac Surgical Procedures, Monitoring, Intraoperative instrumentation, Thrombelastography, Ultrasonics instrumentation
- Abstract
Background: Measures of the sonorheometry based Quantra® viscoelastic hemostatic analyzer (HemoSonics, LCC, Charlottesville, VA, USA) were compared with corresponding results of the ROTEM® sigma device (Instrumentation Laboratory, Bedford, MA, USA)., Methods: In thirty-eight patients scheduled for elective cardiac surgery between December 2018 and October 2019, blood samples were taken after induction of anesthesia (sample 1) and after heparin neutralization (sample 2) and measured on Quantra (QPlus® Cartridge) and ROTEM sigma (ROTEM® sigma complete + hep Cartridge). Clot times and clot stiffness values were recorded. Clot stiffness values of ROTEM amplitudes (A in mm) were converted to shear modulus (G) in hectoPascal (hPa): G (hPa) = (5 x A)/(100-A). Additionally, time-to-results was recorded. Spearman rank test correlation and Bland Altman analysis were performed., Results: Clot stiffness parameters of the Quantra correlated strongly with corresponding measurements of the ROTEM with r = 0.93 and 0.94 for EXTEM A10 vs CS and r = 0.94 and 0.96 for FIBTEM A10 vs FCS for sample 1 and 2, respectively. Quantra clot time correlated strongly with ROTEM INTEM CT with r = 0.71 for sample 1 and r = 0.75 for sample 2. However, Bland Altman analysis showed no agreement in all compared assays of both methods. The median time to delivery of first and complete results was significantly shorter for Quantra (412 and 658 s) compared to ROTEM sigma (839 and 1290 s)., Conclusions: The Quantra showed a strong correlation with the ROTEM sigma for determining clot times and clot stiffness and the parameters assess similar aspects of clot development. However, these parameters are not directly interchangeable and implicate that separate cut-off values need to be established for users of the Quantra device. Word count: 278., Trial Registration: The study was retrospectively registered with ClinicalTrials.gov (ID: NCT04210830 ) at December 20th 2019., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
175. Short term general anesthesia for retro-bulbar block in ophthalmic surgery generates no significant hypercapnia.
- Author
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Baulig W, Weber M, Beck-Schimmer B, Theusinger OM, and Biro P
- Subjects
- Aged, Anesthesia, General adverse effects, Apnea complications, Blood Gas Analysis, Carbon Dioxide metabolism, Equipment Design, Female, Humans, Male, Middle Aged, Oxygen metabolism, Respiration, Artificial, Thiopental administration & dosage, Anesthesia, General methods, Hypercapnia etiology, Ophthalmologic Surgical Procedures methods
- Abstract
To assess the impact of short time hypnosis for retro-bulbar anesthesia on ventilation in patients undergoing ophthalmic surgery of the anterior eye chamber. In all patients, a combined continuous transcutaneous carbon dioxide tension (PtcCO
2 ) and partial oxygen saturation (SpO2 ) measurement was applied in addition to routine monitoring. To enable unconscious application of retro-bulbar anesthesia, intravenous thiopental was given in one to multiple bolus doses. Transient breathing support included chin lift, Esmarch maneuver and manual hand-bag ventilation via face mask. Main endpoints were apnea time, recovery time according to the Richmond Agitation Sedation Scale, as well as SpO2 and PtcCO2 readings at predefined time points. Fifty-two patients with a mean age of 68 ± 13 years were included. Average thiopental dose was 2.7 ± 0.6 mg/kg. In seven (13.5%) patients repeated doses of thiopental were necessary to a total of 3.3 ± 1.1 mg/kg. Except one patient, no severe, significant or clinical relevant hypercapnia or desaturation periods were observed, and the occurring elevation of PtcCO2 values did not correlate with the application of repeated doses of thiopental or the need for the Esmarch maneuver. Higher PtcCO2 values were associated with the presence of hypertension and smoking. Apnea (p < 0.001) and recovery (p = 0.003) time were significantly prolonged in the patients needing the Esmarch maneuver. Short term anesthesia with thiopental in ophthalmic surgery is associated with a mild but not clinically relevant hypercapnia.- Published
- 2018
- Full Text
- View/download PDF
176. Accuracy of non-invasive continuous total hemoglobin measurement by Pulse CO-Oximetry in severe traumatized and surgical bleeding patients.
- Author
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Baulig W, Seifert B, Spahn DR, and Theusinger OM
- Subjects
- Adult, Aged, Algorithms, Emergency Medicine methods, Female, Hemoglobinometry methods, Hemorrhage, Humans, Linear Models, Male, Middle Aged, Patient Admission, Prospective Studies, Reproducibility of Results, Sample Size, Blood Loss, Surgical, Hemoglobins analysis, Monitoring, Intraoperative methods, Monitoring, Physiologic methods, Oximetry methods
- Abstract
The Masimo Radical-7 Pulse CO-Oximeter (Masimo Corp., USA) non-invasively computes hemoglobin concentration (SpHb). SpHb was compared to Co-Oximeter readings (CoOxHb) of arterial samples in surgery patients of the emergency department. Forty-six patients were enrolled. The Masimo R1 25L (revision F and G) adult adhesive sensor was attached to the ring finger of the arterially cannulated hand. Before start, every 30 min during surgery and in the case of severe bleeding SpHb and CoOxHb values were documented. SpHb and post hoc adjusted SpHb (AdSpHb) values were analyzed. Linear regression analysis and Bland-Altman plot for agreement were performed. The detection failure rate of SpHb was 24.5 %. CoOxHb and SpHb showed a strong correlation (r = +0.81), but agreement was moderate [bias (LOA) of -0.6 (-3.0; +1.9)] g/dl. Positive and negative predicted value was 0.49 and 0.69. Exclusion of changes of CoOxHb values ≤1 g/dl resulted in a positive and negative predictive value of 0.66 and 1.00. Post hoc adjustment of the SpHb (AdSpHb) improved linear correlation of CoOxHb and AdSpHb [r = +0.90 (p < 0.001)] but less the agreement [bias (LOA) of CoOxHb and AdSpHb = -0.1 (-2.1/+1.9) g/dl]. SpHb agreed only moderately with CoOxHb values and predicted decreases of CoOxHb only if changes of SpHb ≤ 1.0 g/dl were excluded. The detection failure rate of SpHb was high. At present, additional refinements of the current technology are necessary to further improve performance of non-invasive hemoglobin measurement in the clinical setting.
- Published
- 2017
- Full Text
- View/download PDF
177. Transcutaneous continuous carbon dioxide tension monitoring reduced incidence, degree and duration of hypercapnia during combined regional anaesthesia and monitored anaesthesia care in shoulder surgery patients.
- Author
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Baulig W, Keselj M, Baulig B, Guzzella S, Borgeat A, and Aguirre J
- Subjects
- Adult, Anesthetics, Intravenous therapeutic use, Female, Humans, Hypercapnia prevention & control, Incidence, Male, Middle Aged, Monitoring, Physiologic, Oxygen chemistry, Piperidines therapeutic use, Propofol therapeutic use, Prospective Studies, Remifentanil, Reproducibility of Results, Sensitivity and Specificity, Anesthesia, Conduction methods, Blood Gas Monitoring, Transcutaneous methods, Carbon Dioxide chemistry, Hypercapnia diagnosis, Monitoring, Intraoperative methods, Shoulder surgery
- Abstract
We studied the impact of transcutaneous continuous carbon dioxide tension (PtcCO2) monitoring on ventilation and oxygenation during monitored anaesthesia care (MAC) in patients scheduled for shoulder surgery with continuous interscalene block. 50 patients were randomised either to the intervention (I-group) or the control (C-group) group. In both groups MAC was performed using target controlled infusion of propofol and remifentanil. MAC regimen was adapted to PtcCO2 values in the I-group, whereas the C-group was blinded for these values. Primary outcome was the incidence, degree and duration of hypoventilation stages. In the I-group and the C-group the mean ± SD [range] of PtcCO2 and PaCO2 was 5.79 ± 0.84 [4.37] and 5.44 ± 0.59 [2.78] kPa, as well as 6.41 ± 1.17 [6.29] and 6.01 ± 0.96 [7.15] kPa. Periods of PtcCO2/PaCO2 > 6.5 kPa were 21.0 ± 35.7/1.2 ± 4.2 min in the I-group and 45.6 ± 40.0/18.6 ± 26.8 min in the C-group. Severe hypercapnia (PtcCO2 and/or PaCO2 > 7.5 kPa) was dected in 3/0 patients of the I-group and in 10/3 patients of the C-group. PtcCO2 and PaCO2 showed a strong correlation (r = 0.78), but only moderate agreement with a mean bias (LOA) of -0.37 (-1.69; +0.95) kPa showing an overestimation of the PaCO2. Sensitivity and specificity of PtcCO2 to detect changes of PaCO2 was 0.94 and 0.56, respectively. In no patient SpO2 or SaO2 values lower than 90% were measured. Despite a moderate agreement between PaCO2 and PtcCO2 the PtcCO2 monitoring significantly reduced incidence, degree and duration of hypercapnia in shoulder surgery patients with MAC.
- Published
- 2015
- Full Text
- View/download PDF
178. Measurement of activated coagulation time in children: evaluation of the blood-saving kaolin i-STAT activated coagulation time technique in pediatric cardiac anesthesia.
- Author
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Ulmer FF, Baulig W, Béttex D, Spielmann N, Bürki C, and Weiss M
- Subjects
- Adolescent, Age Factors, Anesthesia methods, Cardiac Surgical Procedures standards, Child, Child, Preschool, Female, Humans, Infant, Male, Monitoring, Intraoperative instrumentation, Monitoring, Intraoperative methods, Partial Thromboplastin Time instrumentation, Partial Thromboplastin Time methods, Partial Thromboplastin Time standards, Prospective Studies, Whole Blood Coagulation Time instrumentation, Whole Blood Coagulation Time methods, Anesthesia standards, Blood Coagulation, Cardiopulmonary Bypass standards, Monitoring, Intraoperative standards, Whole Blood Coagulation Time standards
- Abstract
Objective: To compare the activated coagulation times (ACTs) measured with the blood-saving kaolin i-STAT 1 ACT technique (Abbott Point of Care Inc, Princeton, NJ) with ACTs obtained from the widely used ACTR II device (Medtronic, Inc, Minneapolis, MN) in children undergoing cardiac surgery., Design: A prospective, observational single-center study., Participants: Forty-four pediatric cardiac surgery patients., Intervention: Surgery was performed with cardiopulmonary bypass (CPB) necessitating heparinization., Methods and Main Results: ACTs measured on the i-STAT 1 device (2 × 95 μL) were compared with those obtained from the Medtronic ACTR II device (2 × 0.5 mL). Blood samples were drawn before, during, and after heparinization for CPB and paired for statistical analysis. The 2 techniques were compared using simple and multiregression analyses and the Bland-Altman method. In total, 179 intrarater and 142 interrater data pairs were analyzed. The intrarater reliability of the 2 devices was good, with a mean bias and limits of agreement of +2.0 and -55.5/+59.5 seconds for the Medtronic ACTR II and +0.5 and -59.9/+60.9 seconds for the i-STAT 1. An interrater reliability analysis of the mean of simultaneously measured ACT of the Medtronic ACTR II and both i-STAT 1 devices yielded a mean bias of -5.3 seconds and limits of agreement of -210.1/+199.5 seconds. A comparison of the higher of the paired ACT values from both devices showed similar results. After the removal of heparin, the i-STAT 1's ACT values became significantly lower than those measured on the Medtronic ACTR II (p < 0.001). Simple and multiregression analyses revealed that base excess independently influenced the mean bias of the ACT values from the Medtronic ACTR II (p = 0.037) and i-STAT 1 devices (p = 0.036)., Conclusion: The kaolin i-STAT 1 ACT technique agreed well with the Medtronic ACTR II technique during the nonheparinized phase that preceded CPB. The overall agreement between the ACT obtained from the 2 devices was poor. The routine use of i-STAT 1 measured ACT values cannot be recommended as a reliable alternative to the Medtronic ACTR II., (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
179. Clinical validation of a digital transcutaneous PCO2/SpO2 ear sensor in adult patients after cardiac surgery.
- Author
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Baulig W, Schütt P, Roth HR, Hayoz J, and Schmid ER
- Subjects
- Aged, Aged, 80 and over, Bias, Blood Gas Monitoring, Transcutaneous instrumentation, Blood Gas Monitoring, Transcutaneous statistics & numerical data, Carbon Dioxide blood, Ear blood supply, Female, Fingers blood supply, Humans, Male, Middle Aged, Oxygen blood, Blood Gas Monitoring, Transcutaneous methods, Cardiac Surgical Procedures
- Abstract
Objective: The aim of this study was to validate the V-Sign digital sensor (SenTec AG, Therweil, Switzerland) for combined noninvasive assessment of pulse oxymetric oxygen saturation (SpO(2)) and transcutaneous carbon dioxide tension (PtcCO(2)) in adults after cardiac surgery., Methods: In twenty one patients, aged 51-86 years, simultaneous measurements of blood gases with the V-Sign Sensor and with two Nellcor Durasensors (model DS-100A), one at the opposite earlobe and one with a finger clip, were compared first during hyper-, normo- and hypocapnia and at different pulse rates using a pacemaker, and then at 2-h intervals up to 8 h. Agreement was assessed by Bland-Altman analysis., Results: PtcCO(2) data of three patients were excluded because of calibration failure of the device. Median (range) PtcCO(2) for the remaining patients was 5.49 (3.3-7.6) kPa and arterial carbon dioxide tension (PaCO(2)) was 5.43 (3.61-7.41) kPa. Corresponding mean bias was +0.05 kPa and limits of agreement (LOA) were -1.2/+1.3 kPa. During normo- and hypoventilation, mean bias was good at +0.02 and +0.04 kPa respectively, but limits of agreement were poor at -0.67/+0.69 and -0.81/+0.88 kPa. In 10 patients, an initial overshoot of PtcCO(2 )was observed. Mean bias of SpO(2) and pulse rate was close to zero (-1.5% and +0.001 bpm respectively), but limits of agreement were unacceptably high (-21.4/+18.4% and -22.3/+22.3 bpm)., Conclusions: In the present state of development the SenTeC Digital monitor V-Sign device has serious limitations. Additional efforts are necessary to eliminate calibration failures and the initial overshoot of PtcCO(2) as well as to improve detection of SpO(2) and pulse rate.
- Published
- 2007
- Full Text
- View/download PDF
180. Laryngeal damage due to an unexpectedly large and inappropriately designed cuffed pediatric tracheal tube in a 13-month-old child.
- Author
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Dillier CM, Trachsel D, Baulig W, Gysin C, Gerber AC, and Weiss M
- Subjects
- Anesthesia, General, Humans, Infant, Laryngoscopy, Male, Intraoperative Complications etiology, Intubation, Intratracheal adverse effects, Intubation, Intratracheal instrumentation, Larynx injuries
- Abstract
Purpose: To present a case of laryngeal damage in an infant caused by a too large and inappropriately designed cuffed tracheal tube., Clinical Features: A 13-month-old child undergoing cardiac surgery was intubated with an uncuffed endotracheal tube with an internal diameter (ID) of 4.0 mm. Because of an important air leak around the tracheal tube during mechanical ventilation, a cuffed endotracheal tube ID 4.0 mm was inserted. The air leak with the tube cuff not inflated was acceptable at 25 cm H2O airway pressure. After extubation on the third postoperative day, the patient showed increasing stridor and respiratory deterioration. Fibreoptic laryngoscopy of the spontaneously breathing patient showed a large intra-laryngeal web. After surgical removal of the web, the child rapidly recovered and was discharged from the hospital on the 12th postoperative day. Inspection of the 4.0 mm (ID) cuffed tracheal tube revealed a cuff positioned inappropriately high and an increase of 0.7 mm in outer tube diameter compared to the 4.0 mm (ID) uncuffed tracheal tube from the same manufacturer. The tube cuff is likely to be situated within the larynx when placed in accordance to insertion depth formulas or radiological criteria, as used for uncuffed tracheal tubes in children., Conclusion: The larger than expected tracheal tube with its intra-laryngeal cuff position in a 13-month-old child likely caused mucosal damage and an inflammatory reaction within the larynx resulting in granulation tissue formation and fibrous healing around the tracheal tube.
- Published
- 2004
- Full Text
- View/download PDF
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