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1,059 results on '"Bassotti, G."'

152. Is hyperhomocysteinemia relevant in patients with celiac disease?

Author

Casella, G, Bassotti, G, Villanacci, V, Bella, C, Pagni, F, Corti, G, Sabatino, G, Piatti, M, Baldini, V, Baldini, V., PAGNI, FABIO, Casella, G, Bassotti, G, Villanacci, V, Bella, C, Pagni, F, Corti, G, Sabatino, G, Piatti, M, Baldini, V, Baldini, V., and PAGNI, FABIO

Abstract

AIM: To investigate whether this might be related to the presence of hyperhomocysteinemia. METHODS: From January 1998 to December 2008, we evaluated the presence of hyperhomocysteinemia in a series of 165 adult celiac disease (CD) patients (138 females and 27 males, mean age 43 years). RESULTS: Hyperhomocysteinemia was evident in 32 patients (19.3%), although most of them had moderate levels (mean value 25 mcg/ml; range 15-30). Only one patient had a history of myocardial infarction (heterozygosis for N5-N10-metil tetrahydrofolate reductase mutation). CONCLUSION: The systematic assessment of hyperhomocysteinemia seems, at present, unjustified in CD patients. © 2011 Baishideng. All rights reserved

Published
2011

155. Colonoscopic findings in coeliac disease on a gluten-free diet

Author

Casella, G, Villanacci, V, Di Bella, C, de Marco, E, Pagni, F, Drera, E, Ortenzi, R, Baldini, V, Bassotti, G, Casella, G, Villanacci, V, Di Bella, C, de Marco, E, Pagni, F, Drera, E, Ortenzi, R, Baldini, V, and Bassotti, G

Abstract

Background: to date, there are few data on colonoscopic findings in patients with celiac disease, and most of these obtained in patients with iron deficiency anaemia.Aims: we assessed colonoscopic findings in unselected patients with coeliac disease, since there are no studies available also considering morphological aspects, and there is literature suggestion of increased prevalence of colorectal tumours.Material and methods: colonoscopies with multiple biopsies were retrospectively analyzed in 42 coeliac disease patients on gluten-free diet above age 40; 16 had clinical or laboratory features of iron deficiency anaemia. Mucosal biopsies were evaluated for the presence of intraepithelial lymphocytes and of mucosal eosinophils, in addition to conventional histologic assessment, and compared with those obtained in 15 controls.Results: macroscopic abnormalities (polyps, diverticula, inflammatory changes) were found in 26% of patients. Microscopic abnormalities (lymphocytic colitis, melanosis coli, rectal histiocytosis) were found in 36% of patients. None of these findings was found in controls. Coeliac disease patients had significantly higher eosinophil score than controls in the right colon, whereas this was not significantly different between groups in the left colon.Conclusions: colonoscopic findings in coeliac disease on gluten-free diet may reveal significant findings, even in patients without iron deficiency anaemia. There is the need of further studies in larger cohorts of patients to establish whether colonoscopy In these patients may be clinically useful.

Published
2010

159. P.14.3 SPYGLASS SINGLE OPERATOR PER-ORAL CHOLANGIOSCOPY IN THE EVALUATION OF INDETERMINATE BILIARY LESIONS – A SINGLE-CENTER, PROSPECTIVE COHORT STUDY

Author

Manta, R., primary, Cellini, C., additional, Frazzoni, M., additional, Conigliaro, R., additional, Maccio, L., additional, Melotti, G., additional, Dabizzi, E., additional, Bertani, H., additional, Manno, M., additional, Castellani, D., additional, Villanacci, V., additional, and Bassotti, G., additional

Published
2013
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163. Local expansion of allergen-specific CD30+Th2-type gamma delta T cells in bronchial asthma

Author

Spinozzi, F., Agea, E., Bistoni, O., Forenza, N., Monaco, A., Falini, B., Bassotti, G., De Benedictis, F., Grignani, F., and Bertotto, A.

Subjects
Adult, Ki-1 Antigen, Receptors, Antigen, T-Cell, gamma-delta, Cell Separation, respiratory system, Allergens, Flow Cytometry, Asthma, respiratory tract diseases, Clone Cells, Th2 Cells, Chronic Disease, Cytokines, Humans, Child, Bronchoalveolar Lavage Fluid, Lung, Research Article
Abstract

BACKGROUND: T lymphocytes infiltrating airways during the allergic immune response play a fundamental role in recruiting other specialized cells, such as eosinophils, by secreting interleukin 5 (IL-5), and promoting local and systemic IgE synthesis by producing IL-4. Whether these presumed allergen-specific T cells are of mucosal or systemic origin is still a matter of conjecture. MATERIALS AND METHODS: Immunophenotype, IL-4 production, and in vitro proliferative response to specific or unrelated allergens were analyzed in the bronchoalveolar lavage (BAL) fluid lymphocyte suspensions obtained from untreated patients with allergic asthma. Healthy subjects and patients affected by pulmonary sarcoidosis, a granulomatous lung disease characterized by infiltrating Th1 CD4+ lymphocytes, served as controls. RESULTS: The proportions of gamma delta T lymphocytes, mostly CD4+ or CD4- (-)CD8-, was higher in asthmatic subjects than in controls (p < 0.05). Most BAL gamma delta CD4+ lymphocytes of asthmatic patients displayed the T cell receptor (TCR)-gamma delta V delta 1 chain. While CD30 antigen coexpression on the surface of BAL alpha beta(+) T lymphocytes was low (ranging from 5 to 12%), about half of pulmonary gamma delta T cells coexpressed it. These cells produced IL-4 and negligible amounts of interferon-gamma (IFN gamma), and proliferated in vitro in response to purified specific but not unrelated allergens. In contrast, control or sarcoidosis gamma delta T cells never displayed the CD30 surface molecule or produced significant quantities of IL-4. CONCLUSIONS: These findings not only confirm our previous hypothesis that the allergen-specific Th2-type lymphocytes found in the lungs of asthmatic patients are gamma delta T cells belonging to airway mucosal immunocytes, but also strongly support the notion that asthma is a local rather than a systemic disease.

Published
1995

168. P.1.110: CLINICAL PATTERNS CAN DISTINGUISH DIVERTICULAR DISEASE FROM IRRITABLE BOWEL SYNDROME: A CASE-CASE MATCHING STUDY

Author

Cuomo, R., primary, Annibale, B., additional, Barbara, G., additional, Sarnelli, G., additional, Vozzella, L., additional, Cammarota, S., additional, Bassotti, G., additional, Casetti, T., additional, Grassini, M., additional, Ierardi, E., additional, Maconi, G., additional, Marchi, S., additional, Savarino, V., additional, and Usai, P., additional

Published
2011
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174. Eosinophilic esophagitis: an Italian experience

Author

Vindigni, C., primary, Villanacci, V., additional, Marini, M., additional, Rocca, B. J., additional, Frosini, G., additional, Pedruzzi, E., additional, Corazzi, N., additional, Bassotti, G., additional, and Tosi, P., additional

Published
2010
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176. Celiac disease and Hp infection association in Iran

Author

Rostami-Nejad, M., primary, Villanacci, V., additional, Mashayakhi, R., additional, Molaei, M., additional, Bassotti, G., additional, Zojaji, H., additional, Mirstatari, D., additional, Rostami, K., additional, and Zali, M. R., additional

Published
2009
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195. The biology of cypress allergy

Author

Agea, E., primary, Bistoni, O., additional, Russano, A., additional, Corazzi, L., additional, Minelli, L., additional, Bassotti, G., additional, de Benedictis, F.M., additional, and Spinozzi, F., additional

Published
2002
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198. Barrett's esophagus and ineffective esophageal motility (IEM)

Author

Battaglia, E., primary, Serra, A.M., additional, Dughera, L., additional, Cassolino, P., additional, Buonafede, G., additional, Repici, A., additional, Saracco, G., additional, Predebon, S., additional, Rizzetto, M., additional, Bassotti, G., additional, Mioli, P.R., additional, and Emanuelli, G., additional

Published
2000
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200. Experience with a new device for pathological assessment of colonic endoscopic submucosal dissection.

Author

Trecca, A., Marinozzi, G., Villanacci, V., Salemme, M., and Bassotti, G.

Subjects
PATHOLOGY, ENDOSCOPY, DIAGNOSIS, AMNIOSCOPY, ANGIOSCOPY
Abstract

Endoscopic submucosal dissection (ESD) is gaining popularity worldwide in the treatment of neoplastic lesions of the gastrointestinal tract. However, the experience in Western countries is quite limited and restricted to large or academic centers. Besides, this approach requires an optimal pathological assessment. The aim of this study was to report our experience with colonic ESD using a new device that allows complete handling of the resected specimens and especially of lateral margins, for pathological analysis. In a 1-year period, 14 patients (6 men, 8 women, age range 50-82 years) underwent colonic ESD in a non-academic hospital. The endoscopic procedure was carried out successfully en bloc in more than 90 % of cases. Perforation requiring surgery occurred in one patient (7 %). Pathological assessment with the new device allowed entire and complete examination of both the deep and lateral margins of the excised specimens. Colonic ESD is a viable option for non-surgical treatment of large bowel lesions even in relatively small centers and in non-academic settings. The new device allows good handling of the specimens, and it seems to be useful for the entire examination of the resection margins. [ABSTRACT FROM AUTHOR]

Published
2014
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