Search

Your search keyword '"Baskaran Mani"' showing total 652 results
Start Over Author "Baskaran Mani"
652 results on '"Baskaran Mani"'

151. A common variant near TGFBR3 is associated with primary open angle glaucoma

Author

Zhenglin Yang, Tien Yin Wong, Zheng Li, Kei Tashiro, R. Rand Allingham, Julia E. Richards, Nobuo Fuse, Wee Yang Meah, Robert Ritch, Yik Ying Teo, Dan Milea, Takanori Mizoguchi, Puya Gharahkhani, David F. Garway-Heath, David Goh, Yoko Ikeda, Allison E. Ashley Koch, Wang Xu, Baskaran Mani, Ronnie George, Masakazu Nakano, Jessica N. Cooke Bailey, Janey L. Wiggs, Ying Lin, Yutao Liu, Xiao Yu Ng, Hong Zhang, Stuart MacGregor, Leon W. Herndon, Mei Chin Lee, Elaine Chua, Jost B. Jonas, Tran Nguyen Bich Chau, Balekudaru Shantha, Cameron P. Simmons, SR Krishnadas, Kazuhiko Mori, Ching-Lin Ho, Rupert R A Bourne, Augusto Azuara Blanco, Ching-Yu Cheng, Kathryn P. Burdon, Liza-Sharmini Ahmad Tajudin, Shamira A. Perera, Do Nhu Hon, Louis R. Pasquale, Monisha E. Nongpiur, Khaled K. Abu-Amero, Tin Aung, Rahat Husain, Anil Negi, Ningli Wang, Chukai Huang, Jinghong Sang, Mineo Ozaki, Sarangapani Sripriya, E-Shyong Tai, Saleh A. Al-Obeidan, Jong Chul Han, Chiea Chuen Khor, Jia Nee Foo, Mingzhi Zhang, David C Broadway, David A. Mackey, Ryuichi Sato, Songhomita Panda-Jonas, Prasanthi Namburi, Jamie E Craig, Merwyn Chew, Nihong Zhang, Christopher A. Girkin, Jae H. Kang, Blanche Lim, Anita S Y Chan, Yuhong Chen, Michael A. Hauser, Douglas E. Gaasterland, Chi Pui Pang, Daniel H. Su, Pascal Reynier, Azhany Yakub, Pratap Challa, Alex W. Hewitt, Bowen Zhao, Victor H. K. Yong, Saravanan Vijayan, Yi Xin Zeng, Jonathan L. Haines, Essam A. Osman, Pansy O.S. Tam, Lingam Vijaya, Xinghuai Sun, Aurelien Goncalves, Jianjun Liu, Morio Ueno, Sayoko E. Moroi, Shigeru Kinoshita, Liyun Jia, Kengo Yoshii, Seang-Mei Saw, Tina T. Wong, Yaan Fun Chong, Philomenadin Ferdinamarie Sharmila, Changwon Kee, Tan Do, Periasamy Sundaresan, Jin-Xin Bei, Eranga N. Vithana, Christopher Kai-shun Leung, Sohn Seongsoo, and Li Jia Chen

Subjects
Male, Open angle glaucoma, genetic structures, Genotype, Population, Glaucoma, Single-nucleotide polymorphism, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Genetics, medicine, SNP, Humans, education, Molecular Biology, Exome, Genetics (clinical), Alleles, 030304 developmental biology, Aged, Aged, 80 and over, 0303 health sciences, education.field_of_study, Association Studies Articles, Genetic Variation, General Medicine, Odds ratio, Middle Aged, medicine.disease, eye diseases, 3. Good health, 030221 ophthalmology & optometry, Female, Proteoglycans, sense organs, Receptors, Transforming Growth Factor beta, Glaucoma, Open-Angle
Abstract

Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis.

Published
2014

152. Retinoblastoma in Adults

Author

Krishna Kumar, Jyotirmay Biswas, Mahesh P Shanmugam, Dilip Patwardhan, Sengamedu S. Badrinath, and Baskaran Mani

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Retinoblastoma, business.industry, Eye disease, Enucleation, Fundus (eye), medicine.disease, Dermatology, eye diseases, Surgery, Ophthalmology, El Niño, Biopsy, medicine, business, Calcification, Retinopathy
Abstract

Retinoblastoma usually presents in children younger than 5 years. To our knowledge, 20 cases of retinoblastoma in adults (older than 20 years) have been reported in the literature. Of 173 patients with histopathologically proven retinoblastoma seen in our institute, three were adults. All the patients had endophytic tumors with vitreous seeds. Ultrasonography did not reveal calcification in two cases. Immunohistochemistry with neuron-specific enolase was used to confirm the diagnosis in two cases. All three patients ultimately required enucleation. None of the patients had been referred with a diagnosis of retinoblastoma. The diagnosis of retinoblastoma should be considered in cases of whitish mass lesion in the fundus of an adult.

Published
2000
Full Text
View/download PDF

156. Anterior Chamber Angle Assessment System

Author

Fu, Huazhu, primary, Xu, Yanwu, additional, Kee Wong, Damon Wing, additional, Liu, Jiang, additional, Baskaran, Mani, additional, Perera, Shamira A., additional, and Aung, Tin, additional

Published
2016
Full Text
View/download PDF

158. Shape Changes of the Anterior Lamina Cribrosa in Normal, Ocular Hypertensive, and Glaucomatous Eyes Following Acute Intraocular Pressure Elevation

Author

Tun, Tin A., primary, Thakku, Sri Gowtham, additional, Png, Owen, additional, Baskaran, Mani, additional, Htoon, Hla M., additional, Sharma, Sourabh, additional, Nongpiur, Monisha E., additional, Cheng, Ching-Yu, additional, Aung, Tin, additional, Strouthidis, Nicholas G., additional, and Girard, Michaël J. A., additional

Published
2016
Full Text
View/download PDF

159. Reply

Author

Baskaran, Mani, primary and Aung, Tin, additional

Published
2016
Full Text
View/download PDF

162. Reply

Author

Narayanaswamy, Arun, primary, Baskaran, Mani, additional, and Aung, Tin, additional

Published
2016
Full Text
View/download PDF

169. Role of anterior segment optical coherence tomography in angle‐closure disease: a review.

Author

Porporato, Natalia, Baskaran, Mani, and Aung, Tin

Subjects
*OPTICAL coherence tomography, *COHERENCE (Optics), *GONIOSCOPY, *EYE diseases, *GLAUCOMA diagnosis
Abstract

Abstract: This article aims to review the published literature pertaining to the use of anterior segment optical coherence tomography (AS‐OCT) in the evaluation of angle‐closure disease. Searches on the available published literature were last conducted on 15 June 2017. Rated as Level I evidence, we found that AS‐OCT has shown good sensitivity and moderate diagnostic accuracy to detect narrow angles when compared with gonioscopy. AS‐OCT quantitative and qualitative parameters demonstrated strong association with the presence of gonioscopically closed angles. This technology provides an objective non‐contact method of assessing the angle that is well tolerated by the patient and correlates well with the information provided by gonioscopy. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

170. Optic disc dimensions and cup-disc ratios among healthy South Indians: The Chennai Glaucoma Study

Author

Prema Raju, Baskaran Mani, Prashanth Kannan, Ramesh S. Ve, Lingam Vijaya, Hemamalini Arvind, and Ronnie George

Subjects
Adult, Male, medicine.medical_specialty, genetic structures, Epidemiology, Optic Disk, Glaucoma, India, Asian People, Cup-disc ratio, Ophthalmology, medicine, Humans, South indians, business.industry, Middle Aged, medicine.disease, Refractive Errors, eye diseases, medicine.anatomical_structure, Optometry, Female, sense organs, business, Optic disc
Abstract

To present optic disc and cup dimensions, cup-disc ratios (CDRs) and asymmetry among healthy South Indians, and their associations with ocular and systemic variables.A total of 623 healthy phakic participants of the Chennai Glaucoma Study underwent complete eye examinations including optic disc stereo-photography. Planimetry was performed under stereo-viewing conditions. The morphological type of cupping (no cups, steep cups, partly sloping and fully sloping cups) was identified based on a modification of the classification by Jonas et al.( 11 ) The associations of planimetric measures (optic disc area, cup area and vertical cup-disc ratio [VCDR]) with age, gender, height, intraocular pressure, refraction, astigmatism, axial length and corneal thickness as explanatory variables were examined. The associations of asymmetries in the above planimetric measures with age, gender and asymmetries of the above explanatory variables were examined.Mean optic disc and cup areas were 2.82 ± 0.52 mm(2) and 0.53 ± 0.39 mm(2). Mean CDR was 0.36 ± 0.18. Men had larger discs (P = 0.03). Cup area and VCDR revealed significant associations with disc area (P0.0001) and type of cupping (P 0.0001). Mean disc and cup area asymmetries were 0.19 ± 0.16 mm(2) and 0.15 ± 0.15 mm(2). Mean VCDR asymmetry was 0.07 ± 0.08 mm(2). Cup area and VCDR asymmetries showed significant associations with disc area asymmetry (P 0.0001, both) and asymmetry in the presence or absence of physiological cupping, i.e. subjects with physiological cupping in one eye and no cupping in the other (P 0.0001, both).We present normative optic disc, cup and VCDR measures and asymmetries among healthy South Indians. We demonstrated the dependence of VCDR on the morphological type of cupping.

Published
2011

176. Pupil constriction can alter the accuracy of dark room provocative test

Author

Bing-song, Wang, Ning-li, Wang, Nathan, Congdon, Kun, Lei, and Baskaran, Mani

Subjects
Adult, Male, Humans, Dark Adaptation, Female, Diagnostic Techniques, Ophthalmological, Middle Aged, Glaucoma, Angle-Closure, Sensitivity and Specificity, Aged, Ultrasonography
Abstract

Primary angle-closure glaucoma (PACG) is a major cause of visual morbidity in East Asia. Dark-room provocative test (DRPT) has been used to determine which narrow angles have the risk to develop angle closure. However, the accuracy of DRPT might be altered because that after emerging from the dark room, the configuration of the angle is affected by the light of the slit-lamp and the appositionally closed angle reopens. The aim of this study was to examine the pupillary diameter in different light conditions and use it as a parameter to assess the accuracy of dark-room provocative test.Patients with suspected primary angle-closure glaucoma undergoing DRPT were recruited. The anterior chamber angle was examined by anterior segment optical coherence tomography under the following conditions: (1) in standard room illumination; (2) after short-term dark-adaptation and (3) after DRPT. Mean values of pupil size and numbers of appositionally closed angle under different conditions were compared.A total of 47 eyes of 47 patients were analyzed. The pupil size after DRPT was smaller than that after short-term dark-adaptation (P0.001) and smaller than that in standard room illumination (P = 0.026). The numbers of appositionally closed angles after short-term dark-adaptation were significantly larger than those after DRPT (P0.001). There was no significant difference between the numbers of appositionally closed angles in standard room illumination and after DRPT (P = 0.157).Constriction of pupil size immediately after prolonged dark room provocative test may lead to change in the angle configuration, which may lead to false negative results. We suggest a modified protocol of recording intraocular pressure immediately after DRPT and performing gonioscopy following short-term dark adaptation to improve the accuracy of angle closure assessment.

Published
2009

178. Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes.

Author

Shu Wei Ting, Daniel, Yim-Lui Cheung, Carol, Lim, Gilbert, Siew Wei Tan, Gavin, Quang, Nguyen D., Gan, Alfred, Hamzah, Haslina, Garcia-Franco, Renata, Yew San Yeo, Ian, Shu Yen Lee, Yick Mun Wong, Edmund, Sabanayagam, Charumathi, Baskaran, Mani, Ibrahim, Farah, Ngiap Chuan Tan, Finkelstein, Eric A., Lamoureux, Ecosse L., Wong, Ian Y., Bressler, Neil M., and Sivaprasad, Sobha

Subjects
DEEP learning, DIABETIC retinopathy, RETINAL imaging, PEOPLE with diabetes, GLAUCOMA diagnosis, MEDICAL screening, RETINAL degeneration, EYE diseases, DIAGNOSIS, DISEASES, COMPARATIVE studies, DIABETES, RESEARCH methodology, MEDICAL cooperation, PHARMACOKINETICS, RESEARCH, RETINA, EVALUATION research, ACQUISITION of data, RECEIVER operating characteristic curves
Abstract

Importance: A deep learning system (DLS) is a machine learning technology with potential for screening diabetic retinopathy and related eye diseases.Objective: To evaluate the performance of a DLS in detecting referable diabetic retinopathy, vision-threatening diabetic retinopathy, possible glaucoma, and age-related macular degeneration (AMD) in community and clinic-based multiethnic populations with diabetes.Design, Setting, and Participants: Diagnostic performance of a DLS for diabetic retinopathy and related eye diseases was evaluated using 494 661 retinal images. A DLS was trained for detecting diabetic retinopathy (using 76 370 images), possible glaucoma (125 189 images), and AMD (72 610 images), and performance of DLS was evaluated for detecting diabetic retinopathy (using 112 648 images), possible glaucoma (71 896 images), and AMD (35 948 images). Training of the DLS was completed in May 2016, and validation of the DLS was completed in May 2017 for detection of referable diabetic retinopathy (moderate nonproliferative diabetic retinopathy or worse) and vision-threatening diabetic retinopathy (severe nonproliferative diabetic retinopathy or worse) using a primary validation data set in the Singapore National Diabetic Retinopathy Screening Program and 10 multiethnic cohorts with diabetes.Exposures: Use of a deep learning system.Main Outcomes and Measures: Area under the receiver operating characteristic curve (AUC) and sensitivity and specificity of the DLS with professional graders (retinal specialists, general ophthalmologists, trained graders, or optometrists) as the reference standard.Results: In the primary validation dataset (n = 14 880 patients; 71 896 images; mean [SD] age, 60.2 [2.2] years; 54.6% men), the prevalence of referable diabetic retinopathy was 3.0%; vision-threatening diabetic retinopathy, 0.6%; possible glaucoma, 0.1%; and AMD, 2.5%. The AUC of the DLS for referable diabetic retinopathy was 0.936 (95% CI, 0.925-0.943), sensitivity was 90.5% (95% CI, 87.3%-93.0%), and specificity was 91.6% (95% CI, 91.0%-92.2%). For vision-threatening diabetic retinopathy, AUC was 0.958 (95% CI, 0.956-0.961), sensitivity was 100% (95% CI, 94.1%-100.0%), and specificity was 91.1% (95% CI, 90.7%-91.4%). For possible glaucoma, AUC was 0.942 (95% CI, 0.929-0.954), sensitivity was 96.4% (95% CI, 81.7%-99.9%), and specificity was 87.2% (95% CI, 86.8%-87.5%). For AMD, AUC was 0.931 (95% CI, 0.928-0.935), sensitivity was 93.2% (95% CI, 91.1%-99.8%), and specificity was 88.7% (95% CI, 88.3%-89.0%). For referable diabetic retinopathy in the 10 additional datasets, AUC range was 0.889 to 0.983 (n = 40 752 images).Conclusions and Relevance: In this evaluation of retinal images from multiethnic cohorts of patients with diabetes, the DLS had high sensitivity and specificity for identifying diabetic retinopathy and related eye diseases. Further research is necessary to evaluate the applicability of the DLS in health care settings and the utility of the DLS to improve vision outcomes. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

189. Association of Functional Loss With the Biomechanical Response of the Optic Nerve Head to Acute Transient Intraocular Pressure Elevations

Author

Tun, Tin A., Atalay, Eray, Baskaran, Mani, Nongpiur, Monisha E., Htoon, Hla M., Goh, David, Cheng, Ching-Yu, Perera, Shamira A., Aung, Tin, Strouthidis, Nicholas G., and Girard, Michaël J. A.

Abstract

IMPORTANCE: The acute biomechanical response of the optic nerve head (ONH) to intraocular pressure (IOP) elevations may serve as a biomarker for the development and progression of glaucoma. OBJECTIVE: To evaluate the association between visual field loss and the biomechanical response of the ONH to acute transient IOP elevations. DESIGN, SETTING, AND PARTICIPANTS: In this observational study, 91 Chinese patients (23 with primary open-angle glaucoma [POAG], 45 with primary angle-closure glaucoma, and 23 without glaucoma) were recruited from September 3, 2014, through February 2, 2017. Optical coherence tomography scans of the ONH were acquired at baseline and at 2 sequential IOP elevations (0.64 N and then 0.90 N, by applying forces to the anterior sclera using an ophthalmodynamometer). In each optical coherence tomography volume, lamina cribrosa depth (LCD) and minimum rim width (MRW) were calculated. The mean deviation (MD) and the visual field index (VFI), as assessed by automated perimetry, were correlated with IOP-induced changes of LCD and MRW globally and sectorially. MAIN OUTCOMES AND MEASURES: The LCD, MRW, MD, and VFI. RESULTS: Among the 91 patients, 39 (42.9%) were women; the mean (SD) age was 65.48 (7.23) years. In POAG eyes, a greater change in LCD (anterior displacement) was associated with worse MD and VFI (R = −0.64; 95% CI, −0.97 to −0.31; P = .001; and R = −0.57; 95% CI, −0.94 to −0.19; P = .005, respectively) at the first IOP elevation, and a greater reduction in MRW was also associated with worse MD and VFI (first IOP elevation: R = −0.48; 95% CI, −0.86 to −0.09; P = .02; and R = −0.57; 95% CI, −0.94 to −0.20; P = .004, respectively; second IOP elevation: R = −0.56; 95% CI, −0.98 to −0.13; P = .01; and R = −0.60; 95% CI, −1.03 to −0.17; P = .008, respectively), after adjusting for age, sex, and baseline IOP. A correlation was found between the reduction in MRW in the inferior-temporal sector and the corresponding visual field cluster in POAG eyes at the second elevation (ρ = −0.55; 95% CI, −0.78 to −0.18; P = .006). CONCLUSIONS AND RELEVANCE: The biomechanical response of the ONH to acute IOP elevations was associated with established visual field loss in POAG eyes, but not in primary angle-closure glaucoma eyes. This suggests that ONH biomechanics may be related to glaucoma severity in POAG and that the 2 glaucoma subgroups exhibit inherently different biomechanical properties.

Published
2018
Full Text
View/download PDF

190. Correspondence

Author

Hemamalini Arvind, Prashant Kannan, Ronnie George, S. V. Ramesh, Lingam Vijaya, Baskaran Mani, and Prema Raju

Subjects
Ophthalmology, business.industry, Medicine, Geodesy, business, Vertical cup disc ratio
Published
2007
Full Text
View/download PDF

200. Differential Associations of Myopia with Major Age-related Eye Diseases

Author

Pan, Chen-Wei, primary, Cheung, Carol Y., additional, Aung, Tin, additional, Cheung, Chiu-Ming, additional, Zheng, Ying-Feng, additional, Wu, Ren-Yi, additional, Mitchell, Paul, additional, Lavanya, Raghavan, additional, Baskaran, Mani, additional, Wang, Jie Jin, additional, Wong, Tien Yin, additional, and Saw, Seang-Mei, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results