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Breastfeeding and Human Lactation, Seventh Edition is the ultimate reference for the latest clinical techniques and research findings that direct evidence-based clinical practice and research for lactation consultants and specialists. It contains everything a nurse, lactation consultant, midwife, women's health nurse practitioner, physician assistant, or Ob/Gyn needs to know about lactation care and science. Topics include placing breastfeeding in its historical context, workplace-related issues, anatomical and biological imperatives of lactation, the prenatal and perinatal periods and concerns during the postpartum period, the mother's health, sociocultural issues, and more vital information.

The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic lethality, carbon beam radiation, and other exciting targeted therapies are being studied to improve and advance the studies of modern cancer treatment. The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities. The chapters come from multi-disciplinary backgrounds, including scientists and clinicians from both academia and various industries, to discuss nascent personalized therapies and big data-driven cancer treatment. While highlighting topic areas that include cancer prevention, cancer therapeutics, and cancer treatments through the lenses of technology, medicine/drugs, and alternate therapies, this book is ideally intended for oncologists, radiation oncologists, surgical oncologists, and cancer biologists, along with practitioners, stakeholders, researchers, academicians, and students who are interested in understanding the most fundamental aspects of cancer and the available therapeutic opportunities.

In this compilation, the authors review the available evidence of the benefits of benfotiamine administration, paying particular attention to patients with type 2 diabetes mellitus and diabetic peripheral neuropathy, cardiac autonomic neuropathy and gastrointestinal neuropathy. An overview of cyclic AMP response element binding protein's structure and functions is provided, in addition to a review of its molecular mechanisms and role in disease processes, including neural diseases, diabetes and cancer. Based on bibliographic references and studies carried out by the authors, this work also assesses the problem of modular total hip prostheses, regarded as a closed loop biotribosystem. The best available evidence in the field of dental rehabilitation is discussed, with the goal of constructing a reliable base for the approach of new investigations. In closing, the authors present the synthesis methods and pharmacological properties of triazole-derived heterocyclic systems. Triazoles are an important class of heterocyclic compounds that are five-membered aromatic azole ring with three nitrogen and two carbon atoms.

Das deutsche Gesundheitswesen ist ein sehr komplexes und hoch reguliertes Gebilde, geprägt durch eine historisch bedingte Sektorentrennung, eine staatsmittelbare Selbstverwaltung mit immer neuen Regulationen und Gesetzesreformen in zunehmend kürzeren Rhythmen. Zugleich zeichnet sich der erste Gesundheitsmarkt durch eine deutliche Geschlossenheit gegenüber Innovationen aus. Es ist einerseits schwierig, Neuerungen und sektorenübergreifende Versorgungsansätze zu implementieren, andererseits schaffen es viele gute Ideen und erfolgreiche Projekte nicht in die Regelversorgung. Doch knappe finanzielle Ressourcen, die demographische Entwicklung, die wachsenden medizinisch-technischen und digitalen Möglichkeiten sowie die interfachliche und interdisziplinäre Arbeitsteilung fordern geradezu neue intersektorale Ansätze. Tatsächlich gibt es trotz der Hürden gute und funktionierende intersektorale Lösungen. In diesem Herausgeberwerk werden knapp dreißig Best-Practice-Beispiele vorgestellt: Akteure ganz unterschiedlicher Provenienz berichten über ihre Lösungen, die von Kooperation verschiedener selbständiger Akteure bis Integration aller Versorgungsebenen unter einem Dach reichen. Dabei orientieren sie sich an Gütekriterien, wie z.B. Qualität der Patientenversorgung, Effizienzpotenziale, Skalierbarkeit oder Anforderungen an einen notwendigen Strukturwandel. Die Erfahrungen dieser Best-Practice-Beispiele können und sollen für die Weiterentwicklung einer modernen und patientenorientierten intersektoralen Versorgung nutzbar gemacht werden.

The opening chapter of Advances in Medicine and Biology. Volume 143 discusses the main indications of prophylactic oophorectomy, as well as its risks, benefits and impacts on women's quality of life. Additionally, the authors examine PEGylation, a chemical reaction that allows for the conjugation of a polyethylene-glycol group to another compound. Since the commercial release of adagen, the first approved PEGylated drug, PEGylation has proven to be a successful strategy for the generation of efficient drugs. Following this, this compilation analyzes the morphological and functional disorders that may be induced by oxaliplatin. The authors present the possible side effects of this drug upon several organs, as well as the mechanisms that are activated by the nominated drug. The authors also summarize the processes that might be occurring in Werner syndrome cells during DNA replication that then lead to the genomic instability and replication stress and, ultimately, a p38a-induced premature senescence. The results of the authors'studies combining the granulocyte colony-stimulating factor and enteral sorption therapy are presented in the closing chapter to ameliorate common side effects of such potent and toxic anti-cancer alkylating agents, such as melphalan.

Intended for cell biologists, biophysicists, biochemists, molecular biologists, physiologists, researchers in hemostatsis and thrombosis and pathologists, this book provides an insight into cell adhesion from three interdisciplinary perspectives: fundamental facts of adhesion; molecular biochemistry of adhesion and physiological aspects. It summarizes the basic aspects of surfaces in general and describes the theoretical and experimental tools necessary to investigate cell adhesion, including the basic biochemistry and molecular biology of adhesion. The book offers concise treatment of individual topics, features current material, and provides key references as a guide to further study.

This book would like to present the latest findings on different aspects of tumor matrix formation in connection with the tumor progression and metastasis and on alterations in the cellular components of tumor stroma during tumor demarcation and invasion.

This book presents original results on the leading edge of cancer research. Chapter One provides a brief overview of the recent updates in the role of the laboratory in establishing the diagnosis, methods of disease monitoring and mechanisms that contribute to tyrosine kinase inhibitor (TKI) resistance for patients with chronic myeloid leukemia. Chapter Two reviews self-esteem and academic difficulties in preadolescents and adolescents health from pediatric leukemia. Chapter Three analyzes the role of lactoferrin expression in the initiation and progression of most common hormone-dependent cancers. Chapter Four studies the ETS transcription factor FLI-1 as an important player in human cancer. Chapter Five highlights the latest advances in DNA methylation signature- based liquid biopsy. Chapter Six presents data concerning the pharmacological activity of water-soluble complex of quercetin with polyvinylpyrrolidone on the process of bleomycin-induced lung fibrosis in mice. Chapter Seven investigates prospects of enhancing anti-cancer activities of quercetin in the treatment of glioblastoma. Chapter Eight discusses the correction of tumor-associated thrombocytopenia by quercetin. Chapter Nine examines robotic surgery for prostate cancer.

Katrin Burghardt stellt den „state of the art“ des Einweisermanagements in deutschen Akutkliniken dar und zeigt, in welcher Art und Weise und in welchem Umfang Kliniken gezielte Maßnahmen eines Einweisermanagements bereits einsetzen. Sie untersucht, welche möglichen zukünftigen Einsatzfelder und Perspektiven Kranken­häuser im Rahmen des Managements ihrer Einweiserbeziehungen sehen. Die Autorin zeigt auf, dass der Patient aufgrund der zunehmenden Patientensouveränität als Kunde stark an Bedeutung gewinnen wird und die Kliniken sich künftig auf die Rolle eines aktiven Patienten einstellen müssen.

This handbook presents the most recent technological advances and applications in the areas of biomedical photonics. This second edition contains introductory material and covers the state-of-the-art methods and instrumentation for biomedical photonic technologies. It integrates interdisciplinary research and development critically needed for scientists, engineers, manufacturers, teachers, students, and clinical providers to learn about the most recent advances and predicted trends in instrumentation and methods as well as clinical applications in important areas of biomedical photonics. Extensive references are provided to enhance further study.

Shaped by Quantum Theory, Technology, and the Genomics RevolutionThe integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in

This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development.In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology andpathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.

DNA tumor viruses have long been useful experimental models of carcinogenesis and have elucidated several important mechanisms of cell transformation. Re­ search in recent years has shown that human tumors have a multifactorial nature and that some DNA tumor viruses may playa key role in their etiology. The aim of this book is to assess our knowledge of DNA tumor viruses by reviewing animal models, mechanisms of transformation, association with human tumors, and possi­ bilities of prevention and control by vaccination. Animal models of tumor virology have contributed significantly to our under­ standing of the epidemiology and pathogenesis of virus-induced tumors. Bovine papillomaviruses induce papillomas in the intestine of cattle. The papillomas undergo a transition to carcinomas in cows feeding on bracken fern, which pro­ duces a toxin with radiomimetic and immunosuppressive functions. This example of cooperation between a virus and chemical carcinogens parallels the cooperative role of human papillomaviruses (HPVs) and herpes simplex virus type 2 (HSV-2) with environmental carcinogens in the pathogenesis of cervical cancer. Likewise, hepatocarcinomas appearing in woodchucks chronically infected by woodchuck hepatitis virus (WIN) provide strong support for the relationship between hepatitis B virus (HBV) infection and human hepatocellular carcinoma. Also, the fact that WIN DNA integrates closely to cellular oncogenes suggests a possible molecular mechanism for the tumorigenesis induced by HBV.

The books in this acclaimed series are the most detailed, up-to-date accounts of the field available. Volume 3 explores the oncogenic potential shared by retroviruses of different species, the widespread presence of retrovirues in nature, and the role of retroviruses in normal development and pathogenesis.

Diese Doktorarbeit an der Universität St. Gallen (HSG) entwickelt ein Strukturmodell von krankheitsorientierten Zentren an Universitätsklinika. Das Modell basiert auf einer kybernetisch-konstruktivistischen Sichtweise sowie den Erkenntnissen aus umfangreichen Einzelfallstudien in Eusoma-akkreditierten universitären Brustzentren. Es zeigt, welche Strukturen ein idealtypisches Zentrum zum Zweck der optimalen Patientenversorgung aufweisen sollte sowie welches die wesentlichen Herausforderungen im Veränderungsprozess sind. (Damit liefert das Buch Praktikern im Gesundheitswesen wertvolle Hinweise zur Konzeption von universitären Klinikstrukturen, die das Entstehen von krankheitsorientierten Verhaltensweisen wie Interdisziplinarität unterstützen.)​

This reference book provides information on plant cytogenetics for students, instructors, and researchers. Topics covered by international experts include classical cytogenetics of plant genomes; plant chromosome structure; functional, molecular cytology; and genome dynamics. In addition, chapters are included on several methods in plant cytogenetics, informatics, and even laboratory exercises for aspiring or practiced instructors. The book provides a unique combination of historical and modern subject matter, revealing the central role of plant cytogenetics in plant genetics and genomics as currently practiced. This breadth of coverage, together with the inclusion of methods and instruction, is intended to convey a deep and useful appreciation for plant cytogenetics. We hope it will inform and inspire students, researchers, and teachers to continue to employ plant cytogenetics to address fundamental questions about the cytology of plant chromosomes and genomes for years to come.Hank W. Bass is a Professor in the Department of Biological Science at Florida State University.James A. Birchler is a Professor in the Division of Biological Sciences at the University of Missouri.

This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.

In the mid-1980s the European Journal of Biochemistry set out to publish review articles. The enterprise proved successful, resulting in high-level reviews written by well-known scientists appearing in the Journal. The reviews represent emerging and rapidly growing fields of research in fundamental as well as applied areas of biochemistry, such as medicine, biotechnology, agriculture and nutrition. Novel methodological and technological approaches which stimulate biochemical research are also included. The authors of the reviews are explicitly asked to be critical, selective, evaluative and interdisciplinary oriented. The reviews should encourage young scientists to think independently and creatively, and inform active investigators about the state of the art in a given field.

The enormity of the global healthcare costs vical. One-fifth of all cancers worldwide as a result of cancer infliction cannot be are caused by a chronic infection, for overemphasized. There are more than 100 example, human papilloma virus (HPV) types of cancers; any part of the body can causes cervical cancer and hepatitis B be affected. More than 11 million people virus (HBV) causes liver cancer. Tobacco are diagnosed with cancer every year, and use is the most common preventable cause it is estimated that there will be 16 mil- of cancer in the world. Approximately, lion new cases per year by the year 2020. 168,000 cancer deaths are expected to be In 2005, 7. 6 million people died of can- caused by tobacco use. Approximately, cer, that is, 13% of the 58 million deaths 40% of cancer could be prevented, mainly worldwide. It is estimated that 9 million by not using tobacco, having a healthy people will die from cancer worldwide in diet, being physically active, preventing 2015 and 11. 4 million will die in 2030. infections that may cause cancer, reduc- More than 70% of all cancer deaths occur ing exposure to sunlight, and avoidance of in low and middle income countries. excessive alcohol consumption and stress Five major cancer causing overall mor- (anger). A third of cancers could be cured talities per year worldwide are (WHO): if detected early and treated adequately. It is well established that scientific 1. Lung: 1.

This compendium provides a concise and up-to-date assessment of critical recent issues related to erythroid biology. Developmental, epigenetic, methodological, biochemical, and clinical aspects are integrated to provide a powerful overview of their interrelationships and importance to the generation of the red cell. The excitement generated by these novel observations and the anticipation of future directions in studies of the red cell is a highlight of this volume. The first comprehensive volume covering the breadth of the topic The latest advancements that lead to novel directions in the study of red cells An informative discussion of red cells as they relate to the essential oxygen-carrying component of the body

Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers. The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth. Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.

Peptide Characterization and Application Protocols is dedicated entirely to the characterization of peptides and their applications for the study of biochemical systems and the contributing authors are all leaders in the field of peptide research. Part I, Characterization, presents the most recent advances in select analytical techniques, including high-performance liquid chromatography (HPLC) for purification and evaluation of peptides and mass spectrometry (MS) for the analysis of standard and modified peptides. Innovative methods of synthesis and characterization of membrane peptides are also presented. Part II, Application, presents a variety of specific applications for synthetic peptides. The collected protocols demonstrate the systematic manner in which peptides can be constructed, analyzed, and applied to attack contemporary problems in biochemistry, and this book will be an indispensable aid in the pursuit of new directions in peptide research.

Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.

Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology.In 2004, the Institute for Scientific Information released figures showing that the series has an Impact Factor of 2.576, with a half-life of 7.1 years, placing it 11th in the highly competitive category of Virology.

Title from e-book title screen (viewed on March 19, 2005)

Title from ebook title screen (viewed August 31, 2004).