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657 results on '"Bal, A. M."'

158. Corrigendum to ‘Panton-Valentine Leucocidin (PVL) Staphylococcus aureus a position statement from the International Society of Chemotherapy’ [International Journal of Antimicrobial Agents 51/1 (2018) 16-25](S0924857917303941)(10.1016/j.ijantimicag.2017.11.002)

Author

Saeed, K., Gould, I., Esposito, S., Ahmad-Saeed, N., Ahmed, S. S., Alp, E., Bal, A. M., Bassetti, M., Bonnet, E., Chan, M., Coombs, G., Dancer, S. J., David, M. Z., De Simone, G., Dryden, M., Guardabassi, L., Hanitsch, L. G., Hijazi, K., Kruger, R., Lee, A., Leistner, R., Pagliano, P., Righi, E., Schneider-Burrus, S., Skov, R. L., Tattevin, P., Vanwamel, W., Vos, M. C., and Voss, A.

Published
2018

159. Cystic fibrosis in Turkey: First data from the national registry

Author

Dogru, Deniz, primary, Çakır, Erkan, additional, Şişmanlar, Tuğba, additional, Çobanoğlu, Nazan, additional, Pekcan, Sevgi, additional, Cinel, Güzin, additional, Yalçın, Ebru, additional, Kiper, Nural, additional, Şen, Velat, additional, S. Şen, Hadice, additional, Ercan, Ömür, additional, Keskin, Özlem, additional, B. Eltan, Sevgi, additional, Al Shadfan, Lina M., additional, Yazan, Hakan, additional, Altıntaş, Derya U., additional, Şaşihüseyinoğlu, Şenay, additional, Sapan, Nihat, additional, Çekiç, Şükrü, additional, Çokuğraş, Haluk, additional, A. Kılınç, Ayşe, additional, R. Gürsoy, Tuğba, additional, Aslan, Ayşe T., additional, Bingöl, Ayşen, additional, Başaran, Abdurrahman E., additional, Özdemir, Ali, additional, Köse, Mehmet, additional, Hangül, Melih, additional, Emiralioğlu, Nagehan, additional, Tuğcu, Gökçen, additional, Yüksel, Hasan, additional, Yılmaz, Özge, additional, Orhan, Fazıl, additional, Gayretli Aydın, Zeynep G., additional, Topal, Erdem, additional, Tamay, Zeynep, additional, Süleyman, Ayşe, additional, Can, Demet, additional, Bal, Cem M., additional, Çaltepe, Gönül, additional, and Özçelik, Uğur, additional

Published
2019
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162. Correction: KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3

Author

Nagasawa, Maho, primary, Heesters, Balthasar A., additional, Kradolfer, Chantal M.A., additional, Krabbendam, Lisette, additional, Martinez-Gonzalez, Itziar, additional, de Bruijn, Marjolein J.W., additional, Golebski, Korneliusz, additional, Hendriks, Rudi W., additional, Stadhouders, Ralph, additional, Spits, Hergen, additional, and Bal, Suzanne M., additional

Published
2019
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163. KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3

Author

Nagasawa, Maho, primary, Heesters, Balthasar A., additional, Kradolfer, Chantal M.A., additional, Krabbendam, Lisette, additional, Martinez-Gonzalez, Itziar, additional, de Bruijn, Marjolein J.W., additional, Golebski, Korneliusz, additional, Hendriks, Rudi W., additional, Stadhouders, Ralph, additional, Spits, Hergen, additional, and Bal, Suzanne M., additional

Published
2019
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164. Eosinophils capture viruses, a capacity that is defective in asthma

Author

Sabogal Piñeros, Yanaika S., primary, Bal, Suzanne M., additional, Dijkhuis, Annemiek, additional, Majoor, Christof J., additional, Dierdorp, Barbara S., additional, Dekker, Tamara, additional, Hoefsmit, Esmée P., additional, Bonta, Peter I., additional, Picavet, Daisy, additional, van der Wel, Nicole N., additional, Koenderman, Leo, additional, Sterk, Peter J., additional, Ravanetti, Lara, additional, and Lutter, René, additional

Published
2019
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170. Anti–IL-5 in Mild Asthma Alters Rhinovirus-induced Macrophage, B-Cell, and Neutrophil Responses (MATERIAL). A Placebo-controlled, Double-Blind Study

Author

Sabogal Piñeros, Yanaika S., primary, Bal, Suzanne M., additional, van de Pol, Marianne A., additional, Dierdorp, Barbara S., additional, Dekker, Tamara, additional, Dijkhuis, Annemiek, additional, Brinkman, Paul, additional, van der Sluijs, Koen F., additional, Zwinderman, Aeilko H., additional, Majoor, Christof J., additional, Bonta, Peter I., additional, Ravanetti, Lara, additional, Sterk, Peter J., additional, and Lutter, René, additional

Published
2019
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171. An update on Staphylococcus aureus infective endocarditis from the International Society of Antimicrobial Chemotherapy (ISAC)

Author

Saeed, Kordo, primary, Bal, Abhijit M., additional, Gould, Ian M., additional, David, Michael Z., additional, Dryden, Matthew, additional, Giannitsioti, Efthymia, additional, Hijazi, Karolin, additional, Meisner, Jessica A., additional, Esposito, Silvano, additional, Scaglione, Francesco, additional, Tattevin, Pierre, additional, and Voss, Andreas, additional

Published
2019
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174. On the time scale associated with Monte Carlo simulations.

Author

Bal, Kristof M. and Neyts, Erik C.

Subjects
*MONTE Carlo method, *PHASE transitions, *SILICON crystals, *ACTIVATION energy, *POINT defects, *GRAPHENE
Abstract

Uniform-acceptance force-bias Monte Carlo (fbMC) methods have been shown to be a powerful technique to access longer timescales in atomistic simulations allowing, for example, phase transitions and growth. Recently, a new fbMC method, the time-stamped force-bias Monte Carlo (tfMC) method, was derived with inclusion of an estimated effective timescale; this timescale, however, does not seem able to explain some of the successes the method. In this contribution, we therefore explicitly quantify the effective timescale tfMC is able to access for a variety of systems, namely a simple single-particle, one-dimensional model system, the Lennard-Jones liquid, an adatom on the Cu(100) surface, a silicon crystal with point defects and a highly defected graphene sheet, in order to gain new insights into the mechanisms by which tfMC operates. It is found that considerable boosts, up to three orders of magnitude compared to molecular dynamics, can be achieved for solid state systems by lowering of the apparent activation barrier of occurring processes, while not requiring any system-specific input or modifications of the method. We furthermore address the pitfalls of using the method as a replacement or complement of molecular dynamics simulations, its ability to explicitly describe correct dynamics and reaction mechanisms, and the association of timescales to MC simulations in general. [ABSTRACT FROM AUTHOR]

Published
2014
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175. Reaction mechanisms of C(3PJ) and C+(2PJ) with benzene in the interstellar medium from quantum mechanical molecular dynamics simulations.

Author

Izadi, Mohammad Ebrahim, Bal, Kristof M., Maghari, Ali, and Neyts, Erik C.

Abstract

While spectroscopic data on small hydrocarbons in interstellar media in combination with crossed molecular beam (CMB) experiments have provided a wealth of information on astrochemically relevant species, much of the underlying mechanistic pathways of their formation remain elusive. Therefore, in this work, the chemical reaction mechanisms of C(3PJ) + C6H6 and C+(2P) + C6H6 systems using the quantum mechanical molecular dynamics (QMMD) technique at the PBE0-D3(BJ) level of theory is investigated, mimicking a CMB experiment. Both the dynamics of the reactions as well as the electronic structure for the purpose of the reaction network are evaluated. The method is validated for the first reaction by comparison to the available experimental data. The reaction scheme for the C(3PJ) + C6H6 system covers the literature data, e.g. the major products are the 1,2-didehydrocycloheptatrienyl radical (C7H5) and benzocyclopropenyl radical (C6H5–CH), and it reveals the existence of less common pathways for the first time. The chemistry of the C+(2PJ) + C6H6 system is found to be much richer, and we have found that this is because of more exothermic reactions in this system in comparison to those in the C(3PJ) + C6H6 system. Moreover, using the QMMD simulation, a number of reaction paths have been revealed that produce three distinct classes of reaction products with different ring sizes. All in all, at all the collision energies and orientations, the major product is the heptagon molecular ion for the ionic system. It is also revealed that the collision orientation has a dominant effect on the reaction products in both systems, while the collision energy mostly affects the charged system. These simulations both prove the applicability of this approach to simulate crossed molecular beams, and provide fundamental information on reactions relevant for the interstellar medium. [ABSTRACT FROM AUTHOR]

Published
2021
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176. European confederation of medical mycology quality of clinical candidaemia management score: A review of the points based best practice recommendations.

Author

Bal, Abhijit M.

Subjects
*CENTRAL venous catheters, *CANDIDIASIS, *BEST practices, *MYCOLOGY, *FEDERATIONS, *CANDIDEMIA, *MEDICAL informatics
Abstract

Candidaemia is associated with high mortality. In the last few years, several guidelines have been published on the management of Candida bloodstream infection. However, adherence to the practice guidelines has been suboptimal. In order to facilitate and objectively measure the adherence to good practice recommendations, a scoring criterion was published by the European Confederation of Medical Mycology (ECMM). The ECMM Quality (EQUAL) of Clinical Candidaemia Management is an audit tool that comprises of 10 quality indicators. Each quality indicator is allotted between 1 and 3 points. The maximum achievable score is 22 or 19 in patients with or without a central venous catheter, respectively. This paper reviews each of the 10 quality indicators and provides the context for improving quality within the individual domains. The review also suggests areas that are in need of further clarity or areas which merit attention in the future updates of the EQUAL scoring system so that clinicians are able to derive maximum benefit from the audit tool. The EQUAL scoring tool is an important milestone in the quality improvement aspect of the management of candidaemia and contributes to the various components of clinical governance in the management of Candida infection of the bloodstream. [ABSTRACT FROM AUTHOR]

Published
2021
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177. Oceanic dispersal barriers in a holoplanktonic gastropod.

Author

Choo, Le Qin, Bal, Thijs M. P., Goetze, Erica, and Peijnenburg, Katja T. C. A.

Subjects
*CYTOCHROME oxidase, *OCEAN acidification, *GASTROPODA, *GENE flow, *ACCLIMATIZATION, *BIOINDICATORS, *DISPERSAL (Ecology)
Abstract

Pteropods, a group of holoplanktonic gastropods, are regarded as bioindicators of the effects of ocean acidification on open ocean ecosystems, because their thin aragonitic shells are susceptible to dissolution. While there have been recent efforts to address their capacity for physiological acclimation, it is also important to gain predictive understanding of their ability to adapt to future ocean conditions. However, little is known about the levels of genetic variation and large‐scale population structuring of pteropods, key characteristics enabling local adaptation. We examined the spatial distribution of genetic diversity in the mitochondrial cytochrome c oxidase I (COI) and nuclear 28S gene fragments, as well as shell shape variation, across a latitudinal transect in the Atlantic Ocean (35°N–36°S) for the pteropod Limacina bulimoides. We observed high levels of genetic variability (COI π = 0.034, 28S π = 0.0021) and strong spatial structuring (COI ΦST = 0.230, 28S ΦST = 0.255) across this transect. Based on the congruence of mitochondrial and nuclear differentiation, as well as differences in shell shape, we identified a primary dispersal barrier in the southern Atlantic subtropical gyre (15–18°S). This barrier is maintained despite the presence of expatriates, a gyral current system, and in the absence of any distinct oceanographic gradients in this region, suggesting that reproductive isolation between these populations must be strong. A secondary dispersal barrier supported only by 28S pairwise ΦST comparisons was identified in the equatorial upwelling region (between 15°N and 4°S), which is concordant with barriers observed in other zooplankton species. Both oceanic dispersal barriers were congruent with regions of low abundance reported for a similar basin‐scale transect that was sampled 2 years later. Our finding supports the hypothesis that low abundance indicates areas of suboptimal habitat that result in barriers to gene flow in widely distributed zooplankton species. Such species may in fact consist of several populations or (sub)species that are adapted to local environmental conditions, limiting their potential for adaptive responses to ocean changes. Future analyses of genome‐wide diversity in pteropods could provide further insight into the strength, formation and maintenance of oceanic dispersal barriers. [ABSTRACT FROM AUTHOR]

Published
2021
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181. Corrigendum to ‘Panton-Valentine Leucocidin (PVL) Staphylococcus aureus a position statement from the International Society of Chemotherapy’ [International Journal of Antimicrobial Agents 51/1 (2018) 16-25]

Author

Saeed, Kordo, primary, Gould, Ian, additional, Esposito, Silvano, additional, Ahmad-Saeed, Nusreen, additional, Ahmed, Salman Shaheer, additional, Alp, Emine, additional, Bal, Abhijit M., additional, Bassetti, Matteo, additional, Bonnet, Eric, additional, Chan, Monica, additional, Coombs, Geoffrey, additional, Dancer, Stephanie J., additional, David, Michael Z., additional, De Simone, Giuseppe, additional, Dryden, Matthew, additional, Guardabassi, Luca, additional, Hanitsch, Leif G., additional, Hijazi, Karolin, additional, Kruger, Renate, additional, Lee, Andie, additional, Leistner, Rasmus, additional, Pagliano, Pasquale, additional, Righi, Elda, additional, Schneider-Burrus, Sylke, additional, Skov, Robert Leo, additional, Tattevin, Pierre, additional, VanWamel, Willem, additional, Vos, Margreet C., additional, and Voss, Andreas, additional

Published
2018
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187. Panton–Valentine leukocidin-positive Staphylococcus aureus : a position statement from the International Society of Chemotherapy

Author

Saeed, Kordo, primary, Gould, Ian, additional, Esposito, Silvano, additional, Ahmad-Saeed, Nusreen, additional, Ahmed, Salman Shaheer, additional, Alp, Emine, additional, Bal, Abhijit M., additional, Bassetti, Matteo, additional, Bonnet, Eric, additional, Chan, Monica, additional, Coombs, Geoffrey, additional, Dancer, Stephanie J., additional, David, Michael Z., additional, De Simone, Giuseppe, additional, Dryden, Matthew, additional, Guardabassi, Luca, additional, Hanitsch, Leif G., additional, Hijazi, Karolin, additional, Krüger, Renate, additional, Lee, Andie, additional, Leistner, Rasmus, additional, Pagliano, Pasquale, additional, Righi, Elda, additional, Schneider-Burrus, Sylke, additional, Skov, Robert Leo, additional, Tattevin, Pierre, additional, Van Wamel, Willem, additional, Vos, Margreet C., additional, and Voss, Andreas, additional

Published
2018
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189. Design, synthesis and activity of a potent, selective series of N -aryl pyridinone inhibitors of p38 kinase

Author

Dean Messing, Brian S. Hickory, Alan G. Benson, Matthew J. Saabye, Jeff Hitchcock, Heather M. Madsen, Devadas Balekudru, Shaun R. Selness, Richard C. Durley, Laura D. Marrufo, Gary D. Anderson, Li Xing, Kevin D. Jerome, Michael Hepperle, Christie Lance Christopher, Rajesh V. Devraj, Elizabeth G. Webb, Thomas Owen, Ravi G. Kurumbail, Edgardo Alvira, Jeffrey L. Hirsch, Joseph B. Monahan, Paul V. Rucker, Boehm Terri L, Blevis-Bal Radhika M, Huey S. Shieh, John K. Walker, John F. Schindler, Michele A. Promo, Win Naing, and Sheri L. Bonar

Subjects
Male, Pyridones, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, p38 Mitogen-Activated Protein Kinases, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Inhibitory Concentration 50, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Kinase, Aryl, Organic Chemistry, Biological activity, Rats, Enzyme Activation, Pyridazines, Disease Models, Animal, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, Drug Design, Mitogen-activated protein kinase, Microsomes, Liver, biology.protein, Molecular Medicine
Abstract

A series of N-aryl pyridinone inhibitors of p38 mitogen activated protein (MAP) kinase were designed and prepared based on the screening hit SC-25028 (1) and structural comparisons to VX-745 (5). The focus of the investigation targeted the dependence of potency and metabolic stability on the benzyloxy connectivity, the role of the C-6 position and the substitution pattern on the N-phenyl ring. Further optimization produced the highly selective and potent pyridinones 2 and 3. These inhibitors exhibited activity in both acute and chronic models of inflammation.

Published
2011

190. Design, Synthesis, and Biological Evaluation of 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a Potent, Orally Active, Brain Penetrant Inhibitor of Phosphodiesterase 5 (PDE5)

Author

Sandra W. Curtiss, D. Joseph Rogier, Alan MacInnes, Brown David L, Mike B. Tollefson, Brian R. Bond, Yvette M. Fobian, Maddux Todd Michael, Dafydd R. Owen, Jeanne M. Rumsey, Brent V. Mischke, Jerry W. Cubbage, Alan G. Benson, Robert Hughes, Lena L Zhang, E. Jon Jacobsen, Steven E. Heasley, Joseph B. Moon, Ying Yu, John M. Molyneaux, Yi Zheng, Brad A. Acker, Blevis-Bal Radhika M, John N. Freskos, John K. Walker, and Jennie L. Walgren

Subjects
Stereochemistry, Chemistry, Pharmacology, chemistry.chemical_compound, Spontaneously hypertensive rat, Orally active, Design synthesis, In vivo, cGMP-specific phosphodiesterase type 5, Drug Discovery, Molecular Medicine, Potency, Penetrant (biochemical), Biological evaluation
Abstract

We recently described a novel series of aminopyridopyrazinones as PDE5 inhibitors. Efforts toward optimization of this series culminated in the identification of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, which possessed an excellent potency and selectivity profile and demonstrated robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model. Furthermore, this compound is brain penetrant and will be a useful agent for evaluating the therapeutic potential of central inhibition of PDE5. This compound has recently entered clinical trials.

Published
2010

191. Leeftijd, het psychologisch contract en werkattitudes: een meta-analyse

Author

Bal, P. M., Lange, A. H., Paul Jansen, Velde, E. G., UU LEG Research USG Public Matters Managing Social Issues, LS Manag. en Org. van de Dienstverlening, UU LEG Research USG Public Matters, Management and Organisation, School of Business and Economics, and Amsterdam Business Research Institute

Subjects
education, health care economics and organizations, humanities, Work, Health and Performance
Abstract

In deze meta-analyse werden de relaties tussen leeftijd en het psychologisch contract onderzocht. Enerzijds werd verwacht dat leeftijd positief met ervaren werkgeversverplichtingen zou samenhangen, en anderzijds dat leeftijd de relaties tussen psychologisch contractbreuk en werkattitudes zou modereren. De hypotheses werden getoetst door middel van een metaanalyse over 76 studies met in totaal 28773 respondenten. De meta-analyse toont aan dat leeftijd, in tegenstelling tot onze verwachtingen, marginaal negatief met werkgeversverplichtingen samenhing. Oudere werknemers bleken juist lagere verwachtingen van hun werkgever te hebben dan jongere werknemers. Leeftijd bleek inderdaad de relaties tussen psychologisch contractbreuk en werkattitudes te modereren. De relaties tussen contractbreuk enerzijds en vertrouwen en affectieve betrokkenheid anderzijds waren sterker voor jongeren, terwijl de relatie tussen contractbreuk en werktevredenheid sterker was voor ouderen. Dit betekent dat jongeren heftiger reageren op contractbreuk in de mate van vertrouwen en betrokkenheid en ouderen heftiger reageren op contractbreuk in de mate van werktevredenheid. De theoretische en praktische implicaties van de resultaten worden besproken.

Published
2010

192. Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors

Author

Maddux Todd Michael, Yvette M. Fobian, Alan G. Benson, Dafydd R. Owen, Brian R. Bond, Christopher Phillips, Brad A. Acker, E. Jon Jacobsen, Michael John Palmer, D. Joseph Rogier, John M. Molyneaux, Brent V. Mischke, John N. Freskos, Tracy J. Ringer, Andrew Simon Bell, Blevis-Bal Radhika M, Robert Hughes, David G. Brown, Steve E. Heasley, Joseph B. Moon, John K. Walker, Brown David L, William C. Stallings, Michael B. Tollefson, Alan MacInnes, Jerry W. Cubbage, Yung Yu, Margarita Rodriquez-Lens, and Fox David Nathan Abraham

Subjects
medicine.drug_mechanism_of_action, Phosphodiesterase Inhibitors, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Crystallographic data, Crystallography, X-Ray, Biochemistry, Chemical synthesis, QH301, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, 3',5'-Cyclic-GMP Phosphodiesterases, Catalytic Domain, Drug Discovery, Hydrolase, medicine, Animals, Humans, QD, Molecular Biology, Cyclic Nucleotide Phosphodiesterases, Type 5, chemistry.chemical_classification, Cyclic Nucleotide Phosphodiesterases, Type 6, biology, Bicyclic molecule, Phosphoric Diester Hydrolases, Chemistry, Organic Chemistry, Hydrogen-Ion Concentration, Phosphodiesterase 5 Inhibitors, Protein Structure, Tertiary, Rats, Enzyme, Enzyme inhibitor, Drug Design, Pyrazines, biology.protein, Lactam, Molecular Medicine, Phosphodiesterase 5 inhibitor
Abstract

A new class of potent and selective PDE5 inhibitors is disclosed. Guided by X-ray crystallographic data, optimization of an HTS lead led to the discovery of a series of 2-aryl, (N8)-alkyl substituted-6-aminosubstituted pyrido[3,2b]pyrazinones which show potent inhibition of the PDE5 enzyme. Synthetic details and some structure-activity relationships are also presented.

Published
2009

193. Emerging roles of innate lymphoid cells in inflammatory diseases: Clinical implications

Author

Kortekaas Krohn, I., primary, Shikhagaie, M. M., additional, Golebski, K., additional, Bernink, J. H., additional, Breynaert, C., additional, Creyns, B., additional, Diamant, Z., additional, Fokkens, W. J., additional, Gevaert, P., additional, Hellings, P., additional, Hendriks, R. W., additional, Klimek, L., additional, Mjösberg, J., additional, Morita, H., additional, Ogg, G. S., additional, O'Mahony, L., additional, Schwarze, J., additional, Seys, S. F., additional, Shamji, M. H., additional, and Bal, S. M., additional

Published
2017
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198. Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

Author

Shikhagaie, Medya Mara, primary, Björklund, Åsa K., additional, Mjösberg, Jenny, additional, Erjefält, Jonas S., additional, Cornelissen, Anne S., additional, Ros, Xavier Romero, additional, Bal, Suzanne M., additional, Koning, Jasper J., additional, Mebius, Reina E., additional, Mori, Michiko, additional, Bruchard, Melanie, additional, Blom, Bianca, additional, and Spits, Hergen, additional

Published
2017
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