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156 results on '"Baili Chen"'

151. Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression

Author

Christine Y. P. Wong, Wai Kit Chu, Pinjin Hu, Jun Yu, Wai K. Leung, Zhirong Zeng, Baili Chen, Yuen Yee Cheng, and Joseph J.Y. Sung

Subjects
chemistry.chemical_classification, Cancer Research, medicine.medical_specialty, Oncogene, business.industry, Cancer, Peroxisome proliferator-activated receptor, General Medicine, medicine.disease, medicine.disease_cause, Molecular medicine, Endocrinology, Oncology, chemistry, Internal medicine, Gene expression, medicine, Cancer research, Rosiglitazone, business, Stomach cancer, Carcinogenesis, medicine.drug
Abstract

Our previous study demonstrated that PPARgamma ligand rosiglitazone prevents gastric carcinogenesis in rats induced by chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). In this study, we attempted to identify novel anti-cancer mechanisms of rosiglitazone. By examining the gene expression profiles of MNNG-induced and rosiglitazone-treated gastric cancer with Uniset Rat I Bioarray microarray, we identified a gene that showed prominent responses in the rosiglitazone-treated group. The hypertension-related, calcium-regulated gene (HCaRG) was significantly up-regulated in rat gastric carcinoma of the rosiglitazone-treated group when compared with the MNNG group. We further examined HCaRG expression in human gastric cancer and found that the expression of HCaRG was down-regulated in human gastric cancerous tissue. Rosiglitazone markedly induced the expression of HCaRG in the AGS cell line. The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer.

Published
1994

152. The effect of cannabidiol on mouse hepatic microsomal cytochrome P450-dependent anandamide metabolism

Author

Maria Almira Correia, Baili Chen, K. Y. Kim, and Lester M. Bornheim

Subjects
Male, Cannabinoid receptor, Polyunsaturated Alkamides, medicine.medical_treatment, Biophysics, Mice, Inbred Strains, Arachidonic Acids, Biochemistry, Amidohydrolases, Mixed Function Oxygenases, chemistry.chemical_compound, Mice, Cytochrome P-450 Enzyme System, medicine, Animals, Cannabidiol, Molecular Biology, Biotransformation, Chromatography, High Pressure Liquid, biology, Cytochrome P450, Biological activity, Cell Biology, Anandamide, Calcium Channel Blockers, Amides, chemistry, Spectrophotometry, biology.protein, Fatty Acids, Unsaturated, Microsomes, Liver, GPR18, Arachidonic acid, Cannabinoid, medicine.drug, Endocannabinoids
Abstract

Anandamide (arachidonylethanolamide) has been identified as a brain constituent that selectively binds to the cannabinoid receptor and possesses cannabimimetic activity. Cytochromes P450 catalyze the oxidation of arachidonic acid to several metabolites possessing very potent pharmacological activity. We examined whether P450 would also metabolize anandamide, and whether cannabidiol (a cannabinoid which inactivates several P450s) would affect this metabolism. Mouse hepatic P450s were found to metabolize anandamide to at least 10 different metabolites, four of which were characterized by mass spectrometry. Cannabidiol selectively inhibited the formation of two of these four anandamide metabolites. The significance of anandamide metabolism remains to be explored.

Published
1993

155. Bridged derivatives of 2,2'-biimidazole

Author

Veronique Goulle, Baili Chen, and Randolph P. Thummel

Subjects
Stereochemistry, Chemistry, Organic Chemistry, Medicinal chemistry
Abstract

La biimidazolyle-2,2' reagit avec des α,ω-dibromo alcanes et l'α,α'-dibromo xylene; des biimidazolium dianneles sont obtenus, leur conformation et leur comportement redox sont etudies

Published
1989

156. ChemInform Abstract: Bridged Derivatives of 2,2′-Biimidazole

Author

Randolph P. Thummel, Baili Chen, and Veronique Goulle

Subjects
Chemistry, General Medicine, Medicinal chemistry
Abstract

La biimidazolyle-2,2' reagit avec des α,ω-dibromo alcanes et l'α,α'-dibromo xylene; des biimidazolium dianneles sont obtenus, leur conformation et leur comportement redox sont etudies

Published
1989

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