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5,168 results on '"Büchler Markus W"'

152. Inherited Pancreatic Endocrine Tumors

Author

Manoharan, Jerena, Waldmann, Jens, Langer, Peter, Bartsch, Detlef K., Urrutia, Raul A., Section Editor, Büchler, Markus W., Section Editor, Neoptolemos, John, Section Editor, Neoptolemos, John P., editor, Urrutia, Raul, editor, Abbruzzese, James L., editor, and Büchler, Markus W., editor

Published
2018
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153. EGFR (ErbB) Signaling Pathways in Pancreatic Cancer Pathogenesis

Author

Williams, Monique, Lomberk, Gwen, Urrutia, Raul, Urrutia, Raul A., Section Editor, Büchler, Markus W., Section Editor, Neoptolemos, John, Section Editor, Hackert, Thilo, Section Editor, Neoptolemos, John P., editor, Urrutia, Raul, editor, Abbruzzese, James L., editor, and Büchler, Markus W., editor

Published
2018
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154. Apoptosis: Signaling Pathways in Pancreatic Cancer Pathogenesis

Author

McConkey, David J., Choi, Woonyoung, Urrutia, Raul A., Section Editor, Büchler, Markus W., Section Editor, Neoptolemos, John, Section Editor, Hackert, Thilo, Section Editor, Neoptolemos, John P., editor, Urrutia, Raul, editor, Abbruzzese, James L., editor, and Büchler, Markus W., editor

Published
2018
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155. Pancreatic Cancer Stem Cells

Author

Goodwin, Mackenzie, Abel, Ethan V., Purohit, Vinee, Simeone, Diane M., Urrutia, Raul A., Section Editor, Büchler, Markus W., Section Editor, Neoptolemos, John, Section Editor, Neoptolemos, John P., editor, Urrutia, Raul, editor, Abbruzzese, James L., editor, and Büchler, Markus W., editor

Published
2018
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163. Pancreatic Surgery in Children: Complex, Safe, and Effective.

Author

Fuchs, Juri, Loos, Martin, Kinny-Köster, Benedict, Hackert, Thilo, Schneider, Martin, Mehrabi, Arianeb, Berchtold, Christoph, Al-Saeedi, Mohammed, Müller, Beat P., Strobel, Oliver, Feißt, Manuel, Kessler, Markus, Günther, Patrick, and Büchler, Markus W.

Abstract

Objective: The aim of this study was to assess indications for and report outcomes of pancreatic surgery in pediatric patients. Background: Indications for pancreatic surgery in children are rare and data on surgical outcomes after pediatric pancreatic surgery are scarce. Methods: All children who underwent pancreatic surgery at a tertiary hospital specializing in pancreatic surgery between 2003 and 2022 were identified from a prospectively maintained database. Indications, surgical procedures, and perioperative as well as long-termoutcomes were analyzed. Results: In total, 73 childrenwith a mean age of 12.8 years (range: 4 mo to 18 y) underwent pancreatic surgery during the observation period. Indications included chronic pancreatitis (n=35), pancreatic tumors (n=27), and pancreatic trauma (n=11). Distal pancreatectomy was the most frequently performed procedure (n=23), followed by pancreatoduodenectomy (n=19), duodenum-preserving pancreatic head resection (n=10), segmental pancreatic resection (n=7), total pancreatectomy (n=3), and others (n=11). Postoperative morbidity occurred in 25 patients (34.2%), including 7 cases (9.6%) with major complications (Clavien-Dindo=III). There was no postoperative (90-d) mortality. The 5-year overall survival was 90.5%. The 5-year event-free survival of patients with chronic pancreatitis was 85.7%, and 69.0% for patients with pancreatic tumors. Conclusion: This is the largest single-center study on pediatric pancreatic surgery in a Western population. Pediatric pancreatic surgery can be performed safely. Centralization in pancreatic centers with high expertise in surgery of adult and pediatric patients is important as it both affords the benefits of pancreatic surgery experience and ensures that surgical management is adapted to the specific needs of children. [ABSTRACT FROM AUTHOR]

Published
2024
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164. Deep Learning Histology for Prediction of Lymph Node Metastases and Tumor Regression after Neoadjuvant FLOT Therapy of Gastroesophageal Adenocarcinoma.

Author

Jung, Jin-On, Pisula, Juan I., Beyerlein, Xenia, Lukomski, Leandra, Knipper, Karl, Abu Hejleh, Aram P., Fuchs, Hans F., Tolkach, Yuri, Chon, Seung-Hun, Nienhüser, Henrik, Büchler, Markus W., Bruns, Christiane J., Quaas, Alexander, Bozek, Katarzyna, Popp, Felix, and Schmidt, Thomas

Subjects
THERAPEUTIC use of antineoplastic agents, LYMPH nodes, ADENOCARCINOMA, DOCETAXEL, STOMACH tumors, PREDICTION models, RESEARCH funding, ARTIFICIAL intelligence, ESOPHAGEAL tumors, DECISION making in clinical medicine, METASTASIS, DEEP learning, COMBINED modality therapy, OXALIPLATIN, FOLINIC acid, ARTIFICIAL neural networks, FLUOROURACIL, DISEASE progression
Abstract

Simple Summary: The prediction of tumor response after neoadjuvant FLOT therapy is highly necessary. The use of deep learning on gastroesophageal biopsies enabled us to extract predictive information. This prediction model could be easily applied in clinical decision making. Patients could avoid unnecessary treatment or receive an intensified FLOT therapy. Background: The aim of this study was to establish a deep learning prediction model for neoadjuvant FLOT chemotherapy response. The neural network utilized clinical data and visual information from whole-slide images (WSIs) of therapy-naïve gastroesophageal cancer biopsies. Methods: This study included 78 patients from the University Hospital of Cologne and 59 patients from the University Hospital of Heidelberg used as external validation. Results: After surgical resection, 33 patients from Cologne (42.3%) were ypN0 and 45 patients (57.7%) were ypN+, while 23 patients from Heidelberg (39.0%) were ypN0 and 36 patients (61.0%) were ypN+ (p = 0.695). The neural network had an accuracy of 92.1% to predict lymph node metastasis and the area under the curve (AUC) was 0.726. A total of 43 patients from Cologne (55.1%) had less than 50% residual vital tumor (RVT) compared to 34 patients from Heidelberg (57.6%, p = 0.955). The model was able to predict tumor regression with an error of ±14.1% and an AUC of 0.648. Conclusions: This study demonstrates that visual features extracted by deep learning from therapy-naïve biopsies of gastroesophageal adenocarcinomas correlate with positive lymph nodes and tumor regression. The results will be confirmed in prospective studies to achieve early allocation of patients to the most promising treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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167. Management of the pancreatic transection plane after left (distal) pancreatectomy: Expert consensus guidelines by the International Study Group of Pancreatic Surgery (ISGPS)

Author

Miao, Yi, Büchler, Markus W., Fernandez-del Castillo, Carlos, Neoptolemos, John P., Dervenis, Christos, Ghaneh, Paula, Kleeff, Jörg, Shrikhande, Shailesh V., Falconi, Massimo, Takaori, Kyoichi, Tanaka, Masao, Shimosegawa, Tooru, Peng, Yunpeng, Wang, Guangfu, Huang, Xumin, Lu, Zipeng, Yeo, Charles J., Vollmer, Charles M., Jr., Halloran, Christopher M., de Rooij, Thijs, Werner, Jens, Friess, Helmut, Zeh, Herbert J., Izbicki, Jakob R., He, Jin, Laukkarinen, Johanna, Dejong, Cees H., Lillemoe, Keith D., Conlon, Kevin, Gianotti, Luca, Besselink, Marc G., Del Chiaro, Marco, Montorsi, Marco, Bockhorn, Maximilian, Adham, Mustapha, Oláh, Attila, Salvia, Roberto, Hackert, Thilo, Zureikat, Amer H., Ceyhan, Güralp O., and Bassi, Claudio

Published
2020
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168. Symptomatic marginal ulcer after pancreatoduodenectomy

Author

Sulieman, Ibnouf, Strobel, Oliver, Scharenberg, Christian, Mihaljevic, André M., Müller, Beat M., Diener, Markus K., Mehrabi, Arianeb, Schneider, Martin, Berchtold, Christoph, Tjaden, Christin, Hinz, Ulf, Feisst, Manuel, Büchler, Markus W., Hackert, Thilo, and Loos, Martin

Published
2020
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173. Primary Tumor Resection Before Systemic Therapy in Patients With Colon Cancer and Unresectable Metastases: Combined Results of the SYNCHRONOUS and CCRe-IV Trials

Author

Rahbari, Nuh N., primary, Biondo, Sebastiano, additional, Frago, Ricardo, additional, Feißt, Manuel, additional, Kreisler, Esther, additional, Rossion, Inga, additional, Serrano, Monica, additional, Jäger, Dirk, additional, Lehmann, Monika, additional, Sommer, Florian, additional, Dignass, Axel, additional, Bolling, Claus, additional, Vogel, Ilka, additional, Bork, Ulrich, additional, Büchler, Markus W., additional, Folprecht, Gunnar, additional, Kieser, Meinhard, additional, Lordick, Florian, additional, Weitz, Jürgen, additional, Paty, P.B., additional, Hermann, R., additional, and Schmoor, C., additional

Published
2024
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181. Postpancreatectomy Acute Pancreatitis (PPAP): Definition and Grading from the International Study Group for Pancreatic Surgery (ISGPS)

Author

Marchegiani, Giovanni, Barreto, Savio George, Bannone, Elisa, Sarr, Michael, Vollmer, Charles M., Connor, Saxon, Falconi, Massimo, Besselink, Marc G., Salvia, Roberto, Wolfgang, Christopher L., Zyromski, Nicholas J., Yeo, Charles J., Adham, Mustapha, Siriwardena, Ajith K., Takaori, Kyoichi, Hilal, Mohammad Abu, Loos, Martin, Probst, Pascal, Hackert, Thilo, Strobel, Oliver, Busch, Olivier R. C., Lillemoe, Keith D., Miao, Yi, Halloran, Christopher M., Werner, Jens, Friess, Helmut, Izbicki, Jakob R., Bockhorn, Maximillian, Vashist, Yogesh K., Conlon, Kevin, Passas, Ioannis, Gianotti, Luca, Del Chiaro, Marco, Schulick, Richard D., Montorsi, Marco, Oláh, Attila, Fusai, Giuseppe Kito, Serrablo, Alejandro, Zerbi, Alessandro, Fingerhut, Abe, Andersson, Roland, Padbury, Robert, Dervenis, Christos, Neoptolemos, John P., Bassi, Claudio, Büchler, Markus W., and Shrikhande, Shailesh V.

Published
2021
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182. Actual Five-year Survival After Upfront Resection for Pancreatic Ductal Adenocarcinoma: Who Beats the Odds?

Author

Strobel, Oliver, Lorenz, Philipp, Hinz, Ulf, Gaida, Matthias, König, Anna-Katharina, Hank, Thomas, Niesen, Willem, Kaiser, J.ö.rg, Al-Saeedi, Mohammed, Bergmann, Frank, Springfeld, Christoph, Berchtold, Christoph, Diener, Markus K., Schneider, Martin, Mehrabi, Arianeb, Müller-Stich, Beat P., Hackert, Thilo, Jager, Dirk, and Büchler, Markus W.

Published
2022
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200. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Author

Wolpin, Brian M, Rizzato, Cosmeri, Kraft, Peter, Kooperberg, Charles, Petersen, Gloria M, Wang, Zhaoming, Arslan, Alan A, Beane-Freeman, Laura, Bracci, Paige M, Buring, Julie, Canzian, Federico, Duell, Eric J, Gallinger, Steven, Giles, Graham G, Goodman, Gary E, Goodman, Phyllis J, Jacobs, Eric J, Kamineni, Aruna, Klein, Alison P, Kolonel, Laurence N, Kulke, Matthew H, Li, Donghui, Malats, Núria, Olson, Sara H, Risch, Harvey A, Sesso, Howard D, Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C, Albanes, Demetrius, Andreotti, Gabriella, Austin, Melissa A, Barfield, Richard, Basso, Daniela, Berndt, Sonja I, Boutron-Ruault, Marie-Christine, Brotzman, Michelle, Büchler, Markus W, Bueno-de-Mesquita, H Bas, Bugert, Peter, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E, Capurso, Gabriele, Chung, Charles, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Funel, Niccola, Gaziano, J Michael, Giese, Nathalia A, Giovannucci, Edward L, Goggins, Michael, Gorman, Megan J, Gross, Myron, Haiman, Christopher A, Hassan, Manal, Helzlsouer, Kathy J, Henderson, Brian E, Holly, Elizabeth A, Hu, Nan, Hunter, David J, Innocenti, Federico, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J, Khaw, Kay-Tee, Klein, Eric A, Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C, LaCroix, Andrea, Landi, Maria T, Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L, Nakamura, Yusuke, Oberg, Ann L, Owzar, Kouros, Patel, Alpa V, Peeters, Petra HM, Peters, Ulrike, Pezzilli, Raffaele, Piepoli, Ada, Porta, Miquel, Real, Francisco X, Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Shu, Xiao-Ou, Silverman, Debra T, Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Taylor, Philip R, and Theodoropoulos, George E

Subjects
Cancer, Aged, Case-Control Studies, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, White People, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

Published
2014

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