194 results on '"Ather H"'
Search Results
152. Comparative studies on the lipid composition of some digenetic trematodes
- Author
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Yusufi, A.N.K., primary and Siddiqi, Ather H., additional
- Published
- 1976
- Full Text
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153. Spectrophotometric analysis of haemoglobins of some digenetic trematodes and their hosts
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Ashfaq Haider, S., primary and Siddiqi, Ather H., additional
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- 1976
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- View/download PDF
154. Characterization of sterols of three digenetic trematodes of buffalo
- Author
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Siddiqui, Jawed, primary, Siddiqi, Ather H., additional, Itoh, Toshihiro, additional, and Matsumoto, Taro, additional
- Published
- 1985
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155. Three New Species of Orientodiscus (Trematoda: Paramphistomata) from Freshwater Turtles
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Siddiqi, Ather H., primary
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- 1965
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156. A New Species of the Genus Astiotrema Looss, 1900 with a Key to its Species
- Author
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Siddiqi, Ather H., primary
- Published
- 1965
- Full Text
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157. Intersexuality in Tyleptus striatus
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Shamim Jairajpuri, M., primary and Siddiqi, Ather H., additional
- Published
- 1964
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158. A Review of the GenusOxyspiruraDrasche in Stossich, 1897 (Nematoda: Thelaziidae) with Descriptions of Fourteen New Species
- Author
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Jairapuri, Durdana S., primary and Siddiqi, Ather H., additional
- Published
- 1967
- Full Text
- View/download PDF
159. Nonprotein nitrogenous composition of the protonephridial fluid of the trematode Fasciola gigantica
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Lutz, Peter L., primary and Siddiqi, Ather H., additional
- Published
- 1971
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160. Osmotic and ionic regulation in Fasciola gigantica (Trematoda: Digenea)
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Siddiqi, Ather H., primary and Lutz, Peter L., additional
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- 1966
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- View/download PDF
161. Two New Trematodes from Freshwater Turtles in India
- Author
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Siddiqi, Ather H., primary
- Published
- 1965
- Full Text
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162. Annulospira oculata gen. et sp. nov. (Nematoda: Thelaziidae) from India
- Author
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Jairajpuri, Durdana S., primary and Siddiqi, Ather H., additional
- Published
- 1969
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163. Effect of certain metabolic inhibitors and stimulators on oxygen consumption of some digenetic trematodes
- Author
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Wajih A. Nizami and Ather H. Siddiqi
- Subjects
Consumption (economics) ,Oxygen Consumption ,Infectious Diseases ,Biochemistry ,chemistry ,Animals ,chemistry.chemical_element ,Parasitology ,Trematoda ,Enzyme Inhibitors ,Biology ,Oxygen ,Dinitrophenols - Published
- 1978
164. Intersexuality in Tyleptus striatus
- Author
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Ather H. Siddiqi and M. Shamim Jairajpuri
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Immunology ,Zoology ,Animal Science and Zoology ,Biology ,Ecology, Evolution, Behavior and Systematics - Published
- 1964
165. The Benefits of Immigrants to Canada: Evidence on Tax and Public Services
- Author
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Ather H. Akbari
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Economic growth ,education.field_of_study ,Public Administration ,Sociology and Political Science ,media_common.quotation_subject ,Immigration ,Population ,Microdata (statistics) ,Public policy ,Social Welfare ,Census ,Payment ,Immigration policy ,Economics ,Demographic economics ,education ,media_common - Abstract
The life-cycle theory implication that immigrants being young at the time of arrival should benefit the native-born population in a tax-transfer system is analysed for Canada. Microdata from the 1981 Canadian Census of Population are used. Consumption of major public services and payment of major taxes by the average immigrant and non-immigrant households are considered. It is observed that even after they have stayed for 35 years in Canada immigrant households are a source of public fund transfers to non-immigrants. This confirms the life-cycle net benefit hypothesis. Implications for public policy with respect to immigration policy are suggested. (SUMMARY IN FRE) (EXCERPT)
- Published
- 1989
166. Digenetic Trematodes of Marine Fishes of India. Part II. Fellodistomatidae
- Author
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Ather H. Siddiqi and M. Hafeezullah
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Fish migration ,biology ,National museum ,Ecology ,Zoology ,Aquatic animal ,biology.organism_classification ,Family Fellodistomatidae ,Sucker ,Helminths ,Parasitology ,Taxonomy (biology) ,Bucephalidae ,Ecology, Evolution, Behavior and Systematics - Abstract
Ten species in the family Fellodistomatidae Nicoll, 1913, are reported from the marine fishes of India. New genera are: Jonesiella, Allobacciger, and Odontotrema and new species are: Faustula basiri, Jonesiella pomacanthi, Allobacciger macrorchis, Bacciger sardinellae, B. cochinensis, and Paradiscogaster farooqii. Monascus typicus (Odhner, 1911), and Tergestia clonacantha Manter, 1963, are reported for the first time from the Indian region. Faustula gangetica (Srivastava, 1935) Yamaguti, 1958, originally reported from Clupea ilisha, an anadromous species from Allahabad, is reported from a marine fish, Hilsa sinensis (= Clupea toli). A new name, Paradiscogaster yamagutii, is proposed for junior homonym of P. chaetodontis Yamaguti, 1942. The trematodes were collected at Bombay by A. H. Siddiqi in 1963 and by M. Hafeezullah at various places on the east and west coasts of India between 1964 and 1966. Part I (Hafeezullah and Siddiqi, 1970) comprising the families Bucephalidae and Cryptogonimidae is published elsewhere. The fishes were identified by the staff of the Central Marine Fisheries Research Institute, Mandapam, and their up-to-date scientific and common names and family names were provided by Mr. A. G. K. Menon of the Zoological Survey of India. All measurements in descriptions are in microns unless otherwise indicated. The sucker ratios have been calculated by using the transverse axes of both the suckers and taking the width of the oral sucker as one. In the descriptions where axes of measurements are not specifically mentioned, lengths are given first followed by widths. One asterisk indicates new host records and two asterisks indicate records of new locality. The holotypes and representative specimens of known species have been deposited with the Helminthological Collection of the U. S. National Museum. Family Fellodistomatidae Nicoll, 1913 Faustula basiri sp. n.
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- 1970
167. New Names for Jonesiella Hafeezullah and Siddiqi, 1970, and Odontotrema Hafeezullah and Siddiqi, 1970, Both Preoccupied
- Author
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M. Hafeezullah and Ather H. Siddiqi
- Subjects
biology ,Parasitology ,biology.organism_classification ,Odontotrema ,Ecology, Evolution, Behavior and Systematics ,Genealogy - Published
- 1971
168. 144 EFFICACY OF LIDOCAINE JELLY IN PREVENTION OF PROXIMAL MIGRATION OF URETERIC CALCULI DURING INTRACORPOREAL LITHOTRIPSY
- Author
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Ather, H., Zehri, A., Siddiqui, K., and Sulaiman, N.
- Published
- 2008
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169. The facts behind the faces.
- Author
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Akbari, Ather H.
- Subjects
- TOWARD a More Realistic Immigration Policy for Canada (Book), NEW Faces in the Crowd (Book)
- Abstract
Reviews the books `Toward a More Realistic Immigration Policy for Canada,' by Daniel Stoffman and `New Faces in the Crowd: Economic and Social Impacts of Immigration'.
- Published
- 1994
170. Lactate dehydrogenase in two digenetic trematodes and their host
- Author
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Haque, Masoodul, Siddiqi, Ather H., and Siddiqui, Jawed
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- 1990
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171. Management of urinary stones: state of the art and future perspectives by experts in stone disease.
- Author
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Papatsoris A, Alba AB, Galán Llopis JA, Musafer MA, Alameedee M, Ather H, Caballero-Romeu JP, Costa-Bauzá A, Dellis A, El Howairis M, Gambaro G, Geavlete B, Halinski A, Hess B, Jaffry S, Kok D, Kouicem H, Llanes L, Lopez Martinez JM, Popov E, Rodgers A, Soria F, Stamatelou K, Trinchieri A, and Tuerk C
- Subjects
- Humans, Forecasting, Urinary Calculi therapy, Urinary Calculi surgery
- Abstract
Aim: To present state of the art on the management of urinary stones from a panel of globally recognized urolithiasis experts who met during the Experts in Stone Disease Congress in Valencia in January 2024. Options of treatment: The surgical treatment modalities of renal and ureteral stones are well defined by the guidelines of international societies, although for some index cases more alternative options are possible. For 1.5 cm renal stones, both m-PCNL and RIRS have proven to be valid treatment alternatives with comparable stone-free rates. The m-PCNL has proven to be more cost effective and requires a shorter operative time, while the RIRS has demonstrated lower morbidity in terms of blood loss and shorter recovery times. SWL has proven to be less effective at least for lower calyceal stones but has the highest safety profile. For a 6mm obstructing stone of the pelviureteric junction (PUJ) stone, SWL should be the first choice for a stone less than 1 cm, due to less invasiveness and lower risk of complications although it has a lower stone free-rate. RIRS has advantages in certain conditions such as anticoagulant treatment, obesity, or body deformity. Technical issues of the surgical procedures for stone removal: In patients receiving antithrombotic therapy, SWL, PCN and open surgery are at elevated risk of hemorrhage or perinephric hematoma. URS, is associated with less morbidity in these cases. An individualized combined evaluation of risks of bleeding and thromboembolism should determine the perioperative thromboprophylactic strategy. Pre-interventional urine culture and antibiotic therapy are mandatory although UTI treatment is becoming more challenging due to increasing resistance to routinely applied antibiotics. The use of an intrarenal urine culture and stone culture is recommended to adapt antibiotic therapy in case of postoperative infectious complications. Measurements of temperature and pressure during RIRS are vital for ensuring patient safety and optimizing surgical outcomes although techniques of measurements and methods for data analysis are still to be refined. Ureteral stents were improved by the development of new biomaterials, new coatings, and new stent designs. Topics of current research are the development of drug eluting and bioresorbable stents. Complications of endoscopic treatment: PCNL is considered the most invasive surgical option. Fever and sepsis were observed in 11 and 0.5% and need for transfusion and embolization for bleeding in 7 and 0.4%. Major complications, as colonic, splenic, liver, gall bladder and bowel injuries are quite rare but are associated with significant morbidity. Ureteroscopy causes less complications, although some of them can be severe. They depend on high pressure in the urinary tract (sepsis or renal bleeding) or application of excessive force to the urinary tract (ureteral avulsion or stricture). Diagnostic work up: Genetic testing consents the diagnosis of monogenetic conditions causing stones. It should be carried out in children and in selected adults. In adults, monogenetic diseases can be diagnosed by systematic genetic testing in no more than 4%, when cystinuria, APRT deficiency, and xanthinuria are excluded. A reliable stone analysis by infrared spectroscopy or X-ray diffraction is mandatory and should be associated to examination of the stone under a stereomicroscope. The analysis of digital images of stones by deep convolutional neural networks in dry laboratory or during endoscopic examination could allow the classification of stones based on their color and texture. Scanning electron microscopy (SEM) in association with energy dispersive spectrometry (EDS) is another fundamental research tool for the study of kidney stones. The combination of metagenomic analysis using Next Generation Sequencing (NGS) techniques and the enhanced quantitative urine culture (EQUC) protocol can be used to evaluate the urobiome of renal stone formers. Twenty-four hour urine analysis has a place during patient evaluation together with repeated measurements of urinary pH with a digital pH meter. Urinary supersaturation is the most comprehensive physicochemical risk factor employed in urolithiasis research. Urinary macromolecules can act as both promoters or inhibitors of stone formation depending on the chemical composition of urine in which they are operating. At the moment, there are no clinical applications of macromolecules in stone management or prophylaxis. Patients should be evaluated for the association with systemic pathologies., Prophylaxis: Personalized medicine and public health interventions are complementary to prevent stone recurrence. Personalized medicine addresses a small part of stone patients with a high risk of recurrence and systemic complications requiring specific dietary and pharmacological treatment to prevent stone recurrence and complications of associated systemic diseases. The more numerous subjects who form one or a few stones during their entire lifespan should be treated by modifications of diet and lifestyle. Primary prevention by public health interventions is advisable to reduce prevalence of stones in the general population. Renal stone formers at "high-risk" for recurrence need early diagnosis to start specific treatment. Stone analysis allows the identification of most "high-risk" patients forming non-calcium stones: infection stones (struvite), uric acid and urates, cystine and other rare stones (dihydroxyadenine, xanthine). Patients at "high-risk" forming calcium stones require a more difficult diagnosis by clinical and laboratory evaluation. Particularly, patients with cystinuria and primary hyperoxaluria should be actively searched., Future Research: Application of Artificial Intelligence are promising for automated identification of ureteral stones on CT imaging, prediction of stone composition and 24-hour urinary risk factors by demographics and clinical parameters, assessment of stone composition by evaluation of endoscopic images and prediction of outcomes of stone treatments. The synergy between urologists, nephrologists, and scientists in basic kidney stone research will enhance the depth and breadth of investigations, leading to a more comprehensive understanding of kidney stone formation.
- Published
- 2024
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172. STONE Score: A Predictor for Need of Blood Transfusion in Percutaneous Nephrolithotomy.
- Author
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Saeed A, Aziz W, Hashmi AP, and Ather H
- Subjects
- Humans, Female, Male, Cross-Sectional Studies, Adult, Middle Aged, Pakistan epidemiology, Body Mass Index, Risk Factors, Obesity, Nephrolithotomy, Percutaneous, Blood Transfusion statistics & numerical data, Kidney Calculi surgery
- Abstract
Objective: To determine if the STONE score is a predictor of blood transfusion and if patient-related factors, i.e., the presence of comorbidities such as urinary tract infection and obesity, can predict blood transfusion post-percutaneous nephrolithotomy., Study Design: A cross-sectional descriptive study. Place and Duration of the Study: Department of Urology, The Aga Khan University Hospital, Karachi, Pakistan, between March 2022 and 2023., Methodology: All patients admitted for percutaneous nephrolithotomy (PNCL) were included in the study. STONE score and patient related factors were assessed. Chi-square or Fisher's exact test was applied to check the association between the dependent variables (blood transfusion) and the independent variables. Logistic regression analysis was applied to compare the variables responsible for the outcome. Results: During the study period, 150 patients underwent PCNL. After exclusion, 89 patients were included in the study. The mean STONE score was 7.87, and the total number of transfusions was 8 (8.9%). BMI (body mass index) >25kg/m2 and STONE score were found to be significant factors predicting the need for transfusion with p-values of 0.02 and 0.03, respectively. On multivariate analysis, only BMI was found to be a significant contributing factor for blood transfusion., Conclusion: High BMI and STONE score are significant predictive factors for blood transfusion post-PCNL. Blood product arrangements should be restricted to obese patients., Key Words: STONE score, Body mass index, Blood transfusion.
- Published
- 2024
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173. Exploring the untapped pharmacological potential of imidazopyridazines.
- Author
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Malik MS, Alshareef HF, Alfaidi KA, Ather H, Abduljaleel Z, Hussein EM, Moussa Z, and Ahmed SA
- Abstract
Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines. Imidazopyridazines have been primarily studied for their kinase inhibition activity in the development of new anticancer and antimalarial agents. In addition to this, they have also been investigated for their anticonvulsant, antiallergic, antihistamine, antiviral, and antitubercular properties. Herein, we review the background and development of different imidazopyridazines as potential pharmacological agents. Moreover, the scope of this relatively less charted heterocyclic scaffold is also highlighted., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)
- Published
- 2024
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174. Deciphering the emerging role of phytocompounds: Implications in the management of drug-resistant tuberculosis and ATDs-induced hepatic damage.
- Author
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Ansari MA, Shoaib S, Alomary MN, Ather H, Ansari SMA, Hani U, Jamous YF, Alyahya SA, Alharbi JN, Imran MA, Wahab S, Ahmad W, and Islam N
- Subjects
- Humans, Bacterial Proteins genetics, Antitubercular Agents adverse effects, Isoniazid pharmacology, Mutation, Microbial Sensitivity Tests, Drug Resistance, Multiple, Bacterial genetics, Tuberculosis, Multidrug-Resistant microbiology, Mycobacterium tuberculosis genetics, Tuberculosis drug therapy, Tuberculosis microbiology, Liver Diseases, Chemical and Drug Induced Liver Injury drug therapy
- Abstract
Tuberculosis is a disease of poverty, discrimination, and socioeconomic burden. Epidemiological studies suggest that the mortality and incidence of tuberculosis are unacceptably higher worldwide. Genomic mutations in embCAB, embR, katG, inhA, ahpC, rpoB, pncA, rrs, rpsL, gyrA, gyrB, and ethR contribute to drug resistance reducing the susceptibility of Mycobacterium tuberculosis to many antibiotics. Additionally, treating tuberculosis with antibiotics also poses a serious risk of hepatotoxicity in the patient's body. Emerging data on drug-induced liver injury showed that anti-tuberculosis drugs remarkably altered levels of hepatotoxicity biomarkers. The review is an attempt to explore the anti-mycobacterial potential of selected, commonly available, and well-known phytocompounds and extracts of medicinal plants against strains of Mycobacterium tuberculosis. Many studies have demonstrated that phytocompounds such as flavonoids, alkaloids, terpenoids, and phenolic compounds have antibacterial action against Mycobacterium species, inhibiting the bacteria's growth and replication, and sometimes, causing cell death. Phytocompounds act by disrupting bacterial cell walls and membranes, reducing enzyme activity, and interfering with essential metabolic processes. The combination of these processes reduces the overall survivability of the bacteria. Moreover, several phytochemicals have synergistic effects with antibiotics routinely used to treat TB, improving their efficacy and decreasing the risk of resistance development. Interestingly, phytocompounds have been presented to reduce isoniazid- and ethambutol-induced hepatotoxicity by reversing serum levels of AST, ALP, ALT, bilirubin, MDA, urea, creatinine, and albumin to their normal range, leading to attenuation of inflammation and hepatic necrosis. As a result, phytochemicals represent a promising field of research for the development of new TB medicines., Competing Interests: Declaration of Competing Interest The authors declare no competing interests., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2023
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175. Discovery of Novel Myristic Acid Derivatives as N-Myristoyltransferase Inhibitors: Design, Synthesis, Analysis, Computational Studies and Antifungal Activity.
- Author
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Javid S, Ather H, Hani U, Siddiqua A, Asif Ansari SM, Shanmugarajan D, Yogish Kumar H, Arivuselvam R, Purohit MN, and Kumar BRP
- Abstract
In recent years, N-Myristoyltransferase (NMT) has been identified as a new target for the treatment of fungal infections. It is observed that at present, there are increased rates of morbidity and mortality due to fungal infections. Hence, a series of novel myristic acid derivatives were designed via molecular docking studies and ADMET studies by targeting NMT (N-Myristoyltransferase). The designed myristic acid derivatives were synthesized by converting myristic acid into myristoyl chloride and coupling it with aryl amines to yield corresponding myristic acid derivatives. The compounds were purified and characterized via FTIR, NMR and HRMS spectral analyses. In this study, we carried out a target NMT inhibition assay. In the NMT screening assay results, the compounds 3u, 3m and 3t showed better inhibition compared to the other myristic acid derivatives. In an in vitro antifungal evaluation, the myristic acid derivatives were assessed against Candida albicans and Aspergillus niger strains by determining their minimal inhibitory concentrations (MIC
50 ). The compounds 3u, 3k , 3r and 3t displayed superior antifungal capabilities against Candida albicans , and the compounds 3u, 3m and 3r displayed superior antifungal capabilities against Aspergillus niger compared to the standard drug FLZ (fluconazole). Altogether, we identified a new series of antifungal agents.- Published
- 2023
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176. Nanomedicine in the Management of Alzheimer's Disease: State-of-the-Art.
- Author
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Mir Najib Ullah SN, Afzal O, Altamimi ASA, Ather H, Sultana S, Almalki WH, Bharti P, Sahoo A, Dwivedi K, Khan G, Sultana S, Alzahrani A, and Rahman M
- Abstract
Alzheimer's disease (AD) is a deadly, progressive, and irreversible brain condition that impairs cognitive abilities. Globally, it affects 32.6 million individuals, and if no viable therapies are available by 2050, that figure might rise to 139 million. The current course of treatment enhances cognitive abilities and temporarily relieves symptoms, but it does not halt or slow the disease's development. Additionally, treatments are primarily offered in conventional oral dosage forms, and conventional oral treatments lack brain specialization and cause adverse effects, resulting in poor patient compliance. A potential nanotechnology-based strategy can improve the bioavailability and specificity of the drug targeting in the brain. Furthermore, this review extensively summarizes the applications of nanomedicines for the effective delivery of drugs used in the management of AD. In addition, the clinical progress of nanomedicines in AD is also discussed, and the challenges facing the clinical development of nanomedicines are addressed in this article.
- Published
- 2023
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177. Virtual Screening for Identification of Dual Inhibitors against CDK4/6 and Aromatase Enzyme.
- Author
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Adon T, Shanmugarajan D, Ather H, Ansari SMA, Hani U, Madhunapantula SV, and Honnavalli YK
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- Humans, Female, Aromatase, Molecular Docking Simulation, Anastrozole therapeutic use, Molecular Dynamics Simulation, Enzyme Inhibitors therapeutic use, Cyclin-Dependent Kinase 4, Aromatase Inhibitors pharmacology, Aromatase Inhibitors chemistry, Breast Neoplasms drug therapy, Breast Neoplasms pathology
- Abstract
CDK4/6 and aromatase are prominent targets for breast cancer drug discovery and are involved in abnormal cell proliferation and growth. Although aromatase inhibitors have proven to be effective (for example exemestane, anastrozole, letrozole), resistance to treatment eventually occurs through the activation of alternative signaling pathways, thus evading the antiproliferative effects of aromatase inhibitors. One of the evasion pathways is Cylin D-CDK4/6-Rb signaling that promotes tumor proliferation and resistance to aromatase inhibitors. There is significant evidence that the sequential inhibition of both proteins provides therapeutic benefits over the inhibition of one target. The basis of this study objective is the identification of molecules that are likely to inhibit both CDK4/6 and aromatase by computational chemistry techniques, which need further biochemical studies to confirm. Initially, a structure-based pharmacophore model was constructed for each target to screen the sc-PDB database. Consequently, pharmacophore screening and molecular docking were performed to evaluate the potential lead candidates that effectively mapped both of the target pharmacophore models. Considering abemaciclib (CDK4/6 inhibitor) and exemestane (aromatase inhibitor) as reference drugs, four potential virtual hit candidates (1, 2, 3, and 4) were selected based on their fit values and binding interaction after screening a sc-PDB database. Further, molecular dynamics simulation studies solidify the stability of the lead candidate complexes. In addition, ADMET and DFT calculations bolster the lead candidates. Hence, these combined computational approaches will provide a better therapeutic potential for developing CDK4/6-aromatase dual inhibitors for HR+ breast cancer therapy.
- Published
- 2023
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178. Novel Indole-Tethered Chromene Derivatives: Synthesis, Cytotoxic Properties, and Key Computational Insights.
- Author
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Malik MS, Ather H, Asif Ansari SM, Siddiqua A, Jamal QMS, Alharbi AH, Al-Rooqi MM, Jassas RS, Hussein EM, Moussa Z, Obaid RJ, and Ahmed SA
- Abstract
Indole-tethered chromene derivatives were synthesised in a one-pot multicomponent reaction using N -alkyl-1 H -indole-3-carbaldehydes, 5,5-dimethylcyclohexane-1,3-dione, and malononitrile, catalysed by DBU at 60-65 °C in a short reaction time. The benefits of the methodology include non-toxicity, an uncomplicated set-up procedure, a faster reaction time, and high yields. Moreover, the anticancer properties of the synthesised compounds were tested against selected cancer cell lines. The derivatives 4c and 4d displayed very good cytotoxic activity, with IC
50 values ranging from 7.9 to 9.1 µM. Molecular docking revealed the potent derivatives have good binding affinity towards tubulin protein, better than the control, and the molecular dynamic simulations further demonstrated the stability of ligand-receptor interactions. Moreover, the derivatives followed all the drug-likeness filters.- Published
- 2023
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179. Intensity instability and correlation in amplified multimode wave mixing.
- Author
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An H, Owens H, Ather H, Shakouri A, and Hosseini M
- Abstract
The dynamics of optical nonlinearity in the presence of gain and feedback can be complex leading to chaos in certain regimes. Temporal, spectral, spatial, or polarization instability of optical fields can emerge from chaotic response of an optical [Formula: see text] or [Formula: see text] nonlinear medium placed between two cavity mirrors or before a single feedback mirror. The complex mode dynamics, high-order correlations, and transition to instability in these systems are not well known. We consider a [Formula: see text] medium with amplified four-wave mixing process and study noise and correlation between multiple optical modes. Although individual modes show intensity instability, we observe relative intensity noise reduction close to the standard quantum noise, limited by the camera speed. We observe a relative noise reduction of more than 20 dB and fourth-order intensity correlation between four spatial modes. More than 100 distinct correlated quadruple modes can be generated using this process., (© 2022. The Author(s).)
- Published
- 2022
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180. Novel Drug Delivery Systems as an Emerging Platform for Stomach Cancer Therapy.
- Author
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Hani U, Osmani RAM, Yasmin S, Gowda BHJ, Ather H, Ansari MY, Siddiqua A, Ghazwani M, Fatease AA, Alamri AH, Rahamathulla M, Begum MY, and Wahab S
- Abstract
Cancer has long been regarded as one of the world's most fatal diseases, claiming the lives of countless individuals each year. Stomach cancer is a prevalent cancer that has recently reached a high number of fatalities. It continues to be one of the most fatal cancer forms, requiring immediate attention due to its low overall survival rate. Early detection and appropriate therapy are, perhaps, of the most difficult challenges in the fight against stomach cancer. We focused on positive tactics for stomach cancer therapy in this paper, and we went over the most current advancements and progressions of nanotechnology-based systems in modern drug delivery and therapies in great detail. Recent therapeutic tactics used in nanotechnology-based delivery of drugs aim to improve cellular absorption, pharmacokinetics, and anticancer drug efficacy, allowing for more precise targeting of specific agents for effective stomach cancer treatment. The current review also provides information on ongoing research aimed at improving the curative effectiveness of existing anti-stomach cancer medicines. All these crucial matters discussed under one overarching title will be extremely useful to readers who are working on developing multi-functional nano-constructs for improved diagnosis and treatment of stomach cancer.
- Published
- 2022
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181. Development of stealth liposomal formulation of celecoxib: In vitro and in vivo evaluation.
- Author
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Begum MY, M Osmani RA, Alqahtani A, Ghazwani M, Hani U, Ather H, Atiya A, Rahamathulla M, and Siddiqua A
- Subjects
- Celecoxib pharmacology, Humans, Inflammation, Polyethylene Glycols chemistry, Spectroscopy, Fourier Transform Infrared, Tissue Distribution, Cholesterol chemistry, Liposomes chemistry
- Abstract
Celecoxib (CLB) is a highly hydrophobic selective cyclo-oxygenase inhibitor with high plasma protein binding and undergoes extensive hepatic metabolism. CLB is highly effective in the treatment of osteo and rheumatoid arthritis as first line therapy but produces severe gastro-intestinal toxicities and cardiovascular side effects. In this research, stealth liposomes of CLB were developed with the intention to reduce the side effects and increase the accumulation of drug in the sites of inflammation. Stealth liposomes were prepared by thin film hydration technique using distearoylphosphatidylcholine and PE-PEG 2000 with variable amounts of cholesterol and characterized. The effects of various lipids such as hydrogenated soy phosphatidylcholine, dipalmitoyl phosphatidylcholine, distearoylphosphatidylcholine and cholesterol content on % drug encapsulation was investigated. The optimized stealth liposomes were characterized by FT-IR and DSC for possible drug excipients interaction. Pharmacokinetics, pharmacodynamics and biodistribution studies were carried out for the stealth liposomes. The results revealed that the stealth liposomes reduced the inflammation to the larger magnitude and have also sustained the magnitude when compared to free drug along with maximum analgesic response. Higher elimination half-life, AUC, MRT and lowered clearance rate denotes the extended bioavailability of the drug in blood. Biodistribution studies revealed that stealth liposomes extend the circulation time of liposomes in blood by decreasing opsonisation and be less concentrated in kidney, thereby reducing the toxicities to RES and renal organs and facilitate the drug accumulation in the area of inflammation. Our results indicated that CLB, without the requirement of modifications to enhance solubilisation, can be encapsulated and released from liposomal formulations. This new-fangled drug delivery approach may be used to circumvent the low bioavailability and toxic side effects of oral CLB formulations., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2022
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182. A novel perspective approach to explore pros and cons of face mask in prevention the spread of SARS-CoV-2 and other pathogens.
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Ahmad MDF, Wahab S, Ali Ahmad F, Intakhab Alam M, Ather H, Siddiqua A, Amir Ashraf S, Abu Shaphe M, Idreesh Khan M, and Ali Beg R
- Abstract
Corona virus disease 2019 (COVID-19) outbreak has become a severe community health threat across the world. Covid-19 is a major illness, presently there is no as such any medicine and vaccine those can claim for complete treatment. It is spreading particularly in a feeble immune people and casualties are expanding abruptly and put the health system under strain. Among the strategic measures face mask is one of the most used measures to prevent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Wearing a face mask possibly create a false sense of security lead to decline others measures. Face mask could be risk for the people of under lying medical conditions, old age group, outdoor exercise, acute and chronic respiratory disorders and feeble innate immune. Restrictive airflow due to face mask is the main cause of retention of CO2 called hypercapnia that can lead to respiratory failure with symptoms of tachycardia, flushed skin, dizziness, papilledema, seizure and depression. According to latest updates face shield and social distancing could be better substitute of face mask., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2020 The Author(s).)
- Published
- 2021
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183. Surgical education and training.
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Enam SA, Ather H, and Siddiqui N
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- Clinical Competence, Humans, Education, Medical, Graduate, General Surgery education, Internship and Residency
- Published
- 2021
184. An unusual presentation of diffuse large B-cell lymphoma with ureteric involvement: A case report.
- Author
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Zahid N, Ahmed R, Adil S, and Ather H
- Abstract
Introduction: Non-Hodgkin's lymphomas are a heterogeneous group of malignancies in the lymphoid system and ureteric involvement by non-Hodgkin's lymphoma is very rare., Case Presentation: We present a 37-year-old male, presenting with lower urinary tract symptoms and right flank pain. Initially, he presented with lower urinary tract symptoms without having any evidence of urinary tract infection and was managed for nonspecific cystitis. His ureteral histopathology report indicated a diffused infiltration by malignant lymphoid cells and the final diagnosis revealed diffuse large B-cell lymphoma. His positron-emission tomography scan indicated stage 4 disease with skeletal involvement and he was then treated by rituximab, cyclophosphamide, liposomal doxorubicin, vincristine, and methylprednisolone chemotherapy. Later, he was also diagnosed with central nervous system lymphoma and died during his stay in the hospital., Conclusion: Primary diffuse large B-cell lymphoma of the ureter is extremely rare; however, it should be considered in the differential diagnosis for patients presenting with obstructive uropathy as its early detection is crucial for diagnostic and therapeutic treatment., Competing Interests: The authors declare no conflict of interest., (© 2018 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association.)
- Published
- 2018
- Full Text
- View/download PDF
185. Recurrent renal cancer in Birt-Hogg-Dubé syndrome: A case report.
- Author
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Ather H and Zahid N
- Abstract
Introduction: Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant disease. It is caused by constitutional mutations in the FLCN gene. Since BHDS is a rare syndrome therefore it is unknown to many physicians. However, it is important to identify this rare syndrome at early stages because incidence of renal cancer in BHD patients is very high and its detection at early stages can prevent its metastasis. Hence, we want to present a case of BHDS and draw the attention of the treating physician to this rare inherited disorder and discuss its appropriate diagnosis and management., Case Presentation: We present a case of a 50-year old male presented to the consulting clinics of a University Hospital with right flank pain since the last 2 months. The Computed Tomography (CT) and biopsy on the right renal mass indicated clear cell type renal cell carcinoma with significant lymphadenopathy. Past history of cystic lung disease and pneumothorax along with positive finding of renal cell carcinoma on CT and biopsy suggested Birt-Hogg-Dub́e (BHD) syndrome. The patient underwent right radical nephrectomy and lymph node dissection. His 3 months post- surgery follow up CT scan indicated disease recurrence., Conclusion: In conclusion, it is important to identify this rare syndrome at early stages. Diagnosis for the patients with a positive family history for renal cell cancer and pneumothorax should be considered. FLCN sequencing should also be taken into account in patients and their families because incidence of renal cancer in BHD patients is very high and detection at early stages can prevent its metastasis., (Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
186. Characterization of an injectable, degradable polymer for mechanical stabilization of mandibular fractures.
- Author
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Henslee AM, Yoon DM, Lu BY, Yu J, Arango AA, Marruffo LP, Seng L, Anver TD, Ather H, Nair MB, Piper SO, Demian N, Wong ME, Kasper FK, and Mikos AG
- Subjects
- Animals, Biocompatible Materials administration & dosage, Bone Plates, Bone Screws, Compressive Strength, Cross-Linking Reagents pharmacology, Fracture Fixation, Internal, Fumarates administration & dosage, In Vitro Techniques, Injections, Intralesional, Mandibular Fractures surgery, Materials Testing, Models, Anatomic, Pliability, Polymerization, Polypropylenes administration & dosage, Pyrrolidinones pharmacology, Rabbits, Stress, Mechanical, Temperature, Time Factors, Toluidines pharmacology, Toluidines therapeutic use, Torsion, Mechanical, Absorbable Implants, Biocompatible Materials therapeutic use, Bone Cements therapeutic use, Cementoplasty, Fumarates therapeutic use, Mandibular Fractures therapy, Polypropylenes therapeutic use
- Abstract
This study investigated the use of injectable poly(propylene fumarate) (PPF) formulations for mandibular fracture stabilization applications. A full factorial design with main effects analysis was employed to evaluate the effects of the PPF:N-vinyl pyrrolidone (NVP, crosslinking agent) ratio and dimethyl toluidine (DMT, accelerator) concentration on key physicochemical properties including setting time, maximum temperature, mechanical properties, sol fraction, and swelling ratio. Additionally, the effects of formulation crosslinking time on the mechanical and swelling properties were investigated. The results showed that increasing the PPF:NVP ratio from 3:1 to 4:1 or decreasing the DMT concentration from 0.05 to 0.01 v/w % significantly decreased all mechanical properties as well as significantly increased the sol fraction and swelling ratio. Also, increasing the crosslinking time at 37°C from 1 to 7 days significantly increased all mechanical properties and decreased both the sol fraction and swelling ratio. This study further showed that the flexural stiffness of ex vivo stabilized rabbit mandibles increased from 1.7 ± 0.3 N/mm with a traditional mini-plate fixator to 14.5 ± 4.1 N/mm for the 4:1 (0.05 v/w % DMT) PPF formulation at day 1. Overall, the formulations tested in this study were found to have properties suitable for potential further consideration in mandibular fracture fixation applications., (© 2014 Wiley Periodicals, Inc.)
- Published
- 2015
- Full Text
- View/download PDF
187. The Post-Ureteroscopic Lesion Scale (PULS): a multicenter video-based evaluation of inter-rater reliability.
- Author
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Schoenthaler M, Buchholz N, Farin E, Ather H, Bach C, Bach T, Denstedt JD, Fritsche HM, Grasso M, Hakenberg OW, Herwig R, Knoll T, Kuehhas FE, Liatsikos E, Liske P, Marberger M, Osther PJ, Santos JM, Sarica K, Seitz C, Straub M, Traxer O, Trinchieri A, Turney B, and Miernik A
- Subjects
- Humans, Observer Variation, Reproducibility of Results, Surveys and Questionnaires, Videotape Recording, Neoplasm Grading methods, Ureteral Neoplasms diagnosis, Ureteral Neoplasms pathology, Ureteroscopy methods
- Abstract
Purpose: The Post-Ureteroscopic Lesion Scale (PULS) offers a simple grading system for the description of ureteral lesions after ureteroscopy. In this article, we present the results of a video-based multicenter evaluation of the inter-rater reliability of clinically important PULS grades 0-3., Methods: Video sequences at the end of ureteroscopy (final passage) were recorded for 100 consecutive patients at a single institution and assessed by experienced urologists (n = 20) and senior residents (n = 17) at 19 international centers. The cohort included only patients with lesions grades 0-3 (with grades 2 and 3 subsumed as 2 + since distinction is defined by an extravasation of contrast medium in fluoroscopy). The gradings were evaluated for inter-rater reliability and in terms of simplicity, validity, comprehensibility, reproducibility, and usefulness., Results: Overall, inter-rater reliability was high (Kendall's W = 0.69, p < 0.001) and was comparable between specialists (Kendall's W = 0.69, p < 0.001) and residents (Kendall's W = 0.71, p < 0.001). The matched ratings showed grade 0 in 43.0 % of patients and grades 1 or 2 + in 44.0 and 13.0 % of patients, respectively. Results of the questionnaires indicated a high degree of acceptance, with an overall rating of 1.76 (1.64-1.93 for different items, scale 1-6)., Conclusions: Inter-rater reliability of the endoscopically assessable PULS was high among urologists with different levels of experience in different countries worldwide. The validated PULS system may be used for standardized reporting of ureteral lesions/injuries after ureteroscopy. In addition, PULS will enable more selective standardization of indications for postoperative DJ stenting based on the randomized controlled trials.
- Published
- 2014
- Full Text
- View/download PDF
188. Concomitant quadruple dens invaginatus and talon cusp.
- Author
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Ather H and Ather A
- Subjects
- Dental Enamel abnormalities, Humans, Abnormalities, Multiple, Dens in Dente complications, Tooth Crown abnormalities
- Published
- 2013
189. Endodontic involvement of a geminated tooth with talon cusp: a rare occurrence.
- Author
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Tewari T, Ather A, and Ather H
- Subjects
- Adolescent, Female, Fused Teeth diagnostic imaging, Humans, Radiography, Dental, Endodontics, Fused Teeth pathology
- Published
- 2013
190. Lobodontia: the unravelling of the wolf teeth.
- Author
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Ather A, Ather H, Acharya SR, and Radhakrishnan RA
- Subjects
- Adult, Humans, Hypercementosis diagnostic imaging, Male, Radiography, Tooth Crown abnormalities, Tooth Abnormalities diagnostic imaging
- Abstract
Abnormalities of tooth shape and size generally coexist, as both are determined during the morphodifferentiation stage of odontogenesis. This report describes a case of lobodontia exhibiting multiple dental anomalies of which, "fang like" cuspids, multituberculism of molars, hypodontia along with severe generalized microdontia are distinctive. Radiographic features, diagnostic convolutions, differential diagnosis and clinical significance have also been highlighted.
- Published
- 2013
191. Unique case of a geminated supernumerary tooth with trifid crown.
- Author
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Ather A, Ather H, Sheth SM, and Muliya VS
- Abstract
Gemination, a relatively uncommon dental anomaly, is characterized by its peculiar representation as a tooth with a bifid crown and a common root and root canal. It usually occurs in primary dentition. To come across gemination in a supernumerary tooth is a rare phenomenon. The purpose of this paper is to present a unique case of hyperdontia wherein gemination in an impacted supernumerary tooth resulted in a trifid crown unlike the usual bifid crown. The role of conventional radiographs as well as computed tomography, to accurately determine the morphology and spatial location, and to arrive at a diagnosis, is also emphasized in this paper.
- Published
- 2012
- Full Text
- View/download PDF
192. Laparoscopic surgery in urology.
- Author
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Ather H
- Subjects
- Humans, Laparoscopy, Urology methods
- Published
- 1996
193. CNS infections in renal transplant recipients.
- Author
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Hashmi A, Naqvi R, Ather H, Sheikh R, Akhtar F, Naqvi A, and Rizvi A
- Subjects
- Humans, Pakistan, Retrospective Studies, Central Nervous System Diseases epidemiology, Communicable Diseases epidemiology, Kidney Transplantation, Postoperative Complications epidemiology
- Published
- 1995
194. Erythrocytosis in renal transplant recipients.
- Author
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Hussain Z, Hashmi A, Ather H, Mohsin R, Hussain M, Naqvi A, and Rizvi A
- Subjects
- Adolescent, Adult, Azathioprine therapeutic use, Cyclosporine therapeutic use, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Immunosuppressive Agents therapeutic use, Male, Middle Aged, Polycythemia diagnosis, Prednisolone therapeutic use, Retrospective Studies, Time Factors, Kidney Transplantation immunology, Polycythemia epidemiology, Postoperative Complications epidemiology
- Published
- 1995
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