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153. Abstract 3273: Guadecitabine plus ipilimumab in unresectable melanoma: Five-year follow-up and correlation with integrated, multi-omic analysis in the NIBIT-M4 trial

Author

Noviello, Teresa, primary, Giacomo, Anna Maria Di, additional, Caruso, Francesca Pia, additional, Covre, Alessia, additional, Scala, Giovanni, additional, Ferraro, Luigi, additional, Coral, Sandra, additional, Fridman, Wolf H., additional, Sautes-Fridman, Catherine, additional, Mortarini, Roberta, additional, Simonetti, Elena, additional, Lofiego, Maria Fortunata, additional, Bedognetti, Davide, additional, Anichini, Andrea, additional, Ceccarelli, Michele, additional, and Maio, Michele, additional

Published
2023
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154. Supplementary Data from Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma

Author

Anichini, Giulia, primary, Raggi, Chiara, primary, Pastore, Mirella, primary, Carrassa, Laura, primary, Maresca, Luisa, primary, Crivaro, Enrica, primary, Lottini, Tiziano, primary, Duwe, Lea, primary, Andersen, Jesper B., primary, Tofani, Lorenzo, primary, Di Tommaso, Luca, primary, Banales, Jesus M., primary, Arcangeli, Annarosa, primary, Marra, Fabio, primary, and Stecca, Barbara, primary

Published
2023
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155. Data from Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma

Author

Anichini, Giulia, primary, Raggi, Chiara, primary, Pastore, Mirella, primary, Carrassa, Laura, primary, Maresca, Luisa, primary, Crivaro, Enrica, primary, Lottini, Tiziano, primary, Duwe, Lea, primary, Andersen, Jesper B., primary, Tofani, Lorenzo, primary, Di Tommaso, Luca, primary, Banales, Jesus M., primary, Arcangeli, Annarosa, primary, Marra, Fabio, primary, and Stecca, Barbara, primary

Published
2023
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156. Supplementary Figure S2 from Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade

Author

Lo Russo, Giuseppe, primary, Moro, Massimo, primary, Sommariva, Michele, primary, Cancila, Valeria, primary, Boeri, Mattia, primary, Centonze, Giovanni, primary, Ferro, Simona, primary, Ganzinelli, Monica, primary, Gasparini, Patrizia, primary, Huber, Veronica, primary, Milione, Massimo, primary, Porcu, Luca, primary, Proto, Claudia, primary, Pruneri, Giancarlo, primary, Signorelli, Diego, primary, Sangaletti, Sabina, primary, Sfondrini, Lucia, primary, Storti, Chiara, primary, Tassi, Elena, primary, Bardelli, Alberto, primary, Marsoni, Silvia, primary, Torri, Valter, primary, Tripodo, Claudio, primary, Colombo, Mario Paolo, primary, Anichini, Andrea, primary, Rivoltini, Licia, primary, Balsari, Andrea, primary, Sozzi, Gabriella, primary, and Garassino, Marina Chiara, primary

Published
2023
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158. Data from Early Effector T Lymphocytes Coexpress Multiple Inhibitory Receptors in Primary Non–Small Cell Lung Cancer

Author

Tassi, Elena, primary, Grazia, Giulia, primary, Vegetti, Claudia, primary, Bersani, Ilaria, primary, Bertolini, Giulia, primary, Molla, Alessandra, primary, Baldassari, Paola, primary, Andriani, Francesca, primary, Roz, Luca, primary, Sozzi, Gabriella, primary, Pastorino, Ugo, primary, Mortarini, Roberta, primary, and Anichini, Andrea, primary

Published
2023
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159. Supplementary Data from Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade

Author

Lo Russo, Giuseppe, primary, Moro, Massimo, primary, Sommariva, Michele, primary, Cancila, Valeria, primary, Boeri, Mattia, primary, Centonze, Giovanni, primary, Ferro, Simona, primary, Ganzinelli, Monica, primary, Gasparini, Patrizia, primary, Huber, Veronica, primary, Milione, Massimo, primary, Porcu, Luca, primary, Proto, Claudia, primary, Pruneri, Giancarlo, primary, Signorelli, Diego, primary, Sangaletti, Sabina, primary, Sfondrini, Lucia, primary, Storti, Chiara, primary, Tassi, Elena, primary, Bardelli, Alberto, primary, Marsoni, Silvia, primary, Torri, Valter, primary, Tripodo, Claudio, primary, Colombo, Mario Paolo, primary, Anichini, Andrea, primary, Rivoltini, Licia, primary, Balsari, Andrea, primary, Sozzi, Gabriella, primary, and Garassino, Marina Chiara, primary

Published
2023
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160. Supplementary Materials and Methods highlighted from Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade

Author

Lo Russo, Giuseppe, primary, Moro, Massimo, primary, Sommariva, Michele, primary, Cancila, Valeria, primary, Boeri, Mattia, primary, Centonze, Giovanni, primary, Ferro, Simona, primary, Ganzinelli, Monica, primary, Gasparini, Patrizia, primary, Huber, Veronica, primary, Milione, Massimo, primary, Porcu, Luca, primary, Proto, Claudia, primary, Pruneri, Giancarlo, primary, Signorelli, Diego, primary, Sangaletti, Sabina, primary, Sfondrini, Lucia, primary, Storti, Chiara, primary, Tassi, Elena, primary, Bardelli, Alberto, primary, Marsoni, Silvia, primary, Torri, Valter, primary, Tripodo, Claudio, primary, Colombo, Mario Paolo, primary, Anichini, Andrea, primary, Rivoltini, Licia, primary, Balsari, Andrea, primary, Sozzi, Gabriella, primary, and Garassino, Marina Chiara, primary

Published
2023
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161. Supplementary Tables from Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade

Author

Lo Russo, Giuseppe, primary, Moro, Massimo, primary, Sommariva, Michele, primary, Cancila, Valeria, primary, Boeri, Mattia, primary, Centonze, Giovanni, primary, Ferro, Simona, primary, Ganzinelli, Monica, primary, Gasparini, Patrizia, primary, Huber, Veronica, primary, Milione, Massimo, primary, Porcu, Luca, primary, Proto, Claudia, primary, Pruneri, Giancarlo, primary, Signorelli, Diego, primary, Sangaletti, Sabina, primary, Sfondrini, Lucia, primary, Storti, Chiara, primary, Tassi, Elena, primary, Bardelli, Alberto, primary, Marsoni, Silvia, primary, Torri, Valter, primary, Tripodo, Claudio, primary, Colombo, Mario Paolo, primary, Anichini, Andrea, primary, Rivoltini, Licia, primary, Balsari, Andrea, primary, Sozzi, Gabriella, primary, and Garassino, Marina Chiara, primary

Published
2023
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162. Supplementary Figure 1 from Phase II Study of Perifosine and Sorafenib Dual-Targeted Therapy in Patients with Relapsed or Refractory Lymphoproliferative Diseases

Author

Guidetti, Anna, primary, Carlo-Stella, Carmelo, primary, Locatelli, Silvia L., primary, Malorni, Walter, primary, Mortarini, Roberta, primary, Viviani, Simonetta, primary, Russo, Domenico, primary, Marchianò, Alfonso, primary, Sorasio, Roberto, primary, Dodero, Anna, primary, Farina, Lucia, primary, Giordano, Laura, primary, Di Nicola, Massimo, primary, Anichini, Andrea, primary, Corradini, Paolo, primary, and Gianni, Alessandro M., primary

Published
2023
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163. Supplementary Figure 1 from IGKV3 Proteins as Candidate “Off-the-Shelf” Vaccines for Kappa-Light Chain–Restricted B-Cell Non-Hodgkin Lymphomas

Author

Martorelli, Debora, primary, Guidoboni, Massimo, primary, De Re, Valli, primary, Muraro, Elena, primary, Turrini, Riccardo, primary, Merlo, Anna, primary, Pasini, Elisa, primary, Caggiari, Laura, primary, Romagnoli, Luca, primary, Spina, Michele, primary, Mortarini, Roberta, primary, Gasparotto, Daniela, primary, Mazzucato, Mario, primary, Carbone, Antonino, primary, Rosato, Antonio, primary, Anichini, Andrea, primary, and Dolcetti, Riccardo, primary

Published
2023
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164. Supplementary Tables S1 and S2 from Early Effector T Lymphocytes Coexpress Multiple Inhibitory Receptors in Primary Non–Small Cell Lung Cancer

Author

Tassi, Elena, primary, Grazia, Giulia, primary, Vegetti, Claudia, primary, Bersani, Ilaria, primary, Bertolini, Giulia, primary, Molla, Alessandra, primary, Baldassari, Paola, primary, Andriani, Francesca, primary, Roz, Luca, primary, Sozzi, Gabriella, primary, Pastorino, Ugo, primary, Mortarini, Roberta, primary, and Anichini, Andrea, primary

Published
2023
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165. Supplementary Methods, Figures 1 - 12, Table 1 from Role of Apollon in Human Melanoma Resistance to Antitumor Agents That Activate the Intrinsic or the Extrinsic Apoptosis Pathways

Author

Tassi, Elena, primary, Zanon, Marina, primary, Vegetti, Claudia, primary, Molla, Alessandra, primary, Bersani, Ilaria, primary, Perotti, Valentina, primary, Pennati, Marzia, primary, Zaffaroni, Nadia, primary, Milella, Michele, primary, Ferrone, Soldano, primary, Carlo-Stella, Carmelo, primary, Gianni, Alessandro M., primary, Mortarini, Roberta, primary, and Anichini, Andrea, primary

Published
2023
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168. Supplementary Figure Legend and Tables 1 - 5 from IGKV3 Proteins as Candidate “Off-the-Shelf” Vaccines for Kappa-Light Chain–Restricted B-Cell Non-Hodgkin Lymphomas

Author

Martorelli, Debora, primary, Guidoboni, Massimo, primary, De Re, Valli, primary, Muraro, Elena, primary, Turrini, Riccardo, primary, Merlo, Anna, primary, Pasini, Elisa, primary, Caggiari, Laura, primary, Romagnoli, Luca, primary, Spina, Michele, primary, Mortarini, Roberta, primary, Gasparotto, Daniela, primary, Mazzucato, Mario, primary, Carbone, Antonino, primary, Rosato, Antonio, primary, Anichini, Andrea, primary, and Dolcetti, Riccardo, primary

Published
2023
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169. Supplementary Data from Bevacizumab plus Fotemustine as First-line Treatment in Metastatic Melanoma Patients: Clinical Activity and Modulation of Angiogenesis and Lymphangiogenesis Factors

Author

Del Vecchio, Michele, primary, Mortarini, Roberta, primary, Canova, Stefania, primary, Di Guardo, Lorenza, primary, Pimpinelli, Nicola, primary, Sertoli, Mario R., primary, Bedognetti, Davide, primary, Queirolo, Paola, primary, Morosini, Paola, primary, Perrone, Tania, primary, Bajetta, Emilio, primary, and Anichini, Andrea, primary

Published
2023
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170. Supplementary Figures S1 through S28 from Early Effector T Lymphocytes Coexpress Multiple Inhibitory Receptors in Primary Non–Small Cell Lung Cancer

Author

Tassi, Elena, primary, Grazia, Giulia, primary, Vegetti, Claudia, primary, Bersani, Ilaria, primary, Bertolini, Giulia, primary, Molla, Alessandra, primary, Baldassari, Paola, primary, Andriani, Francesca, primary, Roz, Luca, primary, Sozzi, Gabriella, primary, Pastorino, Ugo, primary, Mortarini, Roberta, primary, and Anichini, Andrea, primary

Published
2023
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171. Supplementary Figure 2 from IGKV3 Proteins as Candidate “Off-the-Shelf” Vaccines for Kappa-Light Chain–Restricted B-Cell Non-Hodgkin Lymphomas

Author

Martorelli, Debora, primary, Guidoboni, Massimo, primary, De Re, Valli, primary, Muraro, Elena, primary, Turrini, Riccardo, primary, Merlo, Anna, primary, Pasini, Elisa, primary, Caggiari, Laura, primary, Romagnoli, Luca, primary, Spina, Michele, primary, Mortarini, Roberta, primary, Gasparotto, Daniela, primary, Mazzucato, Mario, primary, Carbone, Antonino, primary, Rosato, Antonio, primary, Anichini, Andrea, primary, and Dolcetti, Riccardo, primary

Published
2023
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173. Data from Mutation-Independent Anaplastic Lymphoma Kinase Overexpression in Poor Prognosis Neuroblastoma Patients

Author

Passoni, Lorena, primary, Longo, Luca, primary, Collini, Paola, primary, Coluccia, Addolorata Maria Luce, primary, Bozzi, Fabio, primary, Podda, Marta, primary, Gregorio, Andrea, primary, Gambini, Claudio, primary, Garaventa, Alberto, primary, Pistoia, Vito, primary, Del Grosso, Federica, primary, Tonini, Gian Paolo, primary, Cheng, Mangeng, primary, Gambacorti-Passerini, Carlo, primary, Anichini, Andrea, primary, Fossati-Bellani, Franca, primary, Di Nicola, Massimo, primary, and Luksch, Roberto, primary

Published
2023
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180. Supplementary Figures 1-10 from Tumor-Reactive CD8+ Early Effector T Cells Identified at Tumor Site in Primary and Metastatic Melanoma

Author

Anichini, Andrea, primary, Molla, Alessandra, primary, Vegetti, Claudia, primary, Bersani, Ilaria, primary, Zappasodi, Roberta, primary, Arienti, Flavio, primary, Ravagnani, Fernando, primary, Maurichi, Andrea, primary, Patuzzo, Roberto, primary, Santinami, Mario, primary, Pircher, Hanspeter, primary, Di Nicola, Massimo, primary, and Mortarini, Roberta, primary

Published
2023
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181. Supplementary Methods, Figures 1-4, Tables 1-3 from Mutation-Independent Anaplastic Lymphoma Kinase Overexpression in Poor Prognosis Neuroblastoma Patients

Author

Passoni, Lorena, primary, Longo, Luca, primary, Collini, Paola, primary, Coluccia, Addolorata Maria Luce, primary, Bozzi, Fabio, primary, Podda, Marta, primary, Gregorio, Andrea, primary, Gambini, Claudio, primary, Garaventa, Alberto, primary, Pistoia, Vito, primary, Del Grosso, Federica, primary, Tonini, Gian Paolo, primary, Cheng, Mangeng, primary, Gambacorti-Passerini, Carlo, primary, Anichini, Andrea, primary, Fossati-Bellani, Franca, primary, Di Nicola, Massimo, primary, and Luksch, Roberto, primary

Published
2023
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184. Digital evaluation of tumor microenvironment immune markers pre- and post-neoadjuvant pembrolizumab in muscle-invasive bladder cancer (Pure-01 trial: An open label, single arm, phase II study).

Author

Cattaneo, Laura, primary, Lagano, Vincenzo, additional, Carpenito, Laura, additional, Napolitano, Caterina, additional, Bersani, Ilaria, additional, Necchi, Andrea, additional, Nicolai, Nicola, additional, Paolini, Biagio, additional, Colecchia, Maurizio, additional, Milione, Massimo, additional, Pruneri, Giancarlo, additional, Mortarini, Roberta, additional, Anichini, Andrea, additional, and Giannatempo, Patrizia, additional

Published
2023
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185. Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma

Author

Anichini, Giulia, primary, Raggi, Chiara, additional, Pastore, Mirella, additional, Carrassa, Laura, additional, Maresca, Luisa, additional, Crivaro, Enrica, additional, Lottini, Tiziano, additional, Duwe, Lea, additional, Andersen, Jesper B., additional, Tofani, Lorenzo, additional, Di Tommaso, Luca, additional, Banales, Jesus M., additional, Arcangeli, Annarosa, additional, Marra, Fabio, additional, and Stecca, Barbara, additional

Published
2023
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186. Guadecitabine plus ipilimumab in unresectable melanoma: five-year follow-up and correlation with integrated, multiomic analysis in the NIBIT-M4 trial

Author

Rosaria Noviello, Teresa Maria, primary, Di Giacomo, Anna Maria, additional, Caruso, Francesca Pia, additional, Covre, Alessia, additional, Scala, Giovanni, additional, Costa, Maria Claudia, additional, Coral, Sandra, additional, Fridman, Wolf H., additional, Sautès-Fridman, Catherine, additional, Mortarini, Roberta, additional, Brich, Silvia, additional, Pruneri, Giancarlo, additional, Simonetti, Elena, additional, Lofiego, Maria Fortunata, additional, Bedognetti, Davide, additional, Anichini, Andrea, additional, Maio, Michele, additional, and Ceccarelli, Michele, additional

Published
2023
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187. Measuring rhythms of vocal interactions: A proof of principle in harbour seal pups

Author

Anichini, M., Reus, K. de, Hersh, T.A.A., Valente, D., Salazar-Casals, A., Berry, C., Keller, P.E., Ravignani, A., Anichini, M., Reus, K. de, Hersh, T.A.A., Valente, D., Salazar-Casals, A., Berry, C., Keller, P.E., and Ravignani, A.

Abstract

Item does not contain fulltext, Emotion regulates our memory in daily life. Previous studies have shown that extrinsic emotion during encoding impairs the memory for target stimulus. However, most previous studies focused on the effects of emotion on the typical encoding without intentional retrieval. It remains unclear how emotion affects the retrieval-based encoding and memory. In the present study, we examined how encoding type (restudy versus retrieval practice) regulates emotional memory retention. We adopted a typical retrieval practice paradigm with an initial study phase, a second phase with either a restudy or a retrieval practice task, and a final recognition test. In order to create extrinsic emotional background, emotional pictures were used during the restudy and retrieval practice tasks. The recognition test was carried out 5 min or 24 h after the restudy or retrieval practice task. We found an emotional impairment effect on familiarity (5-min retention interval) under the retrieval practice condition, but not under the restudy condition, and an emotional enhancement effect on item memory (24-h retention interval) under the restudy condition, but not under the retrieval practice condition. The present study demonstrated the effect of encoding type on emotional memory and suggested a retention interval dependent effect of encoding type, contributing to the theory of emotional memory by highlighting the role of encoding type and retention interval.

Published
2023

188. Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma

Author

Anichini, Giulia, Raggi, Chiara, Pastore, Mirella, Carrassa, Laura, Maresca, Luisa, Crivaro, Enrica, Lottini, Tiziano, Duwe, Lea, Andersen, Jesper B., Tofani, Lorenzo, Di Tommaso, Luca, Banales, Jesus M., Arcangeli, Annarosa, Marra, Fabio, Stecca, Barbara, Anichini, Giulia, Raggi, Chiara, Pastore, Mirella, Carrassa, Laura, Maresca, Luisa, Crivaro, Enrica, Lottini, Tiziano, Duwe, Lea, Andersen, Jesper B., Tofani, Lorenzo, Di Tommaso, Luca, Banales, Jesus M., Arcangeli, Annarosa, Marra, Fabio, and Stecca, Barbara

Abstract

Cholangiocarcinoma (CCA) is characterized by resistance to chemotherapy and a poor prognosis. Therefore, treatments that can effectively suppress tumor growth are urgently needed. Aberrant activation of hedgehog (HH) signaling has been implicated in several cancers, including those of the hepatobiliary tract. However, the role of HH signaling in intrahepatic CCA (iCCA) has not been completely elucidated. In this study, we addressed the function of the main transducer Smoothened (SMO) and the transcription factors (TFs) GLI1 and GLI2 in iCCA. In addition, we evaluated the potential benefits of the combined inhibition of SMO and the DNA damage kinase WEE1. Transcriptomic analysis of 152 human iCCA samples showed increased expression of GLI1, GLI2, and Patched 1 (PTCH1) in tumor tissues compared with nontumor tissues. Genetic silencing of SMO, GLI1, and GLI2 inhibited the growth, survival, invasiveness, and self-renewal of iCCA cells. Pharmacologic inhibition of SMO reduced iCCA growth and viability in vitro, by inducing double-strand break DNA damage, leading to mitotic arrest and apoptotic cell death. Importantly, SMO inhibition resulted in the activation of the G2–M checkpoint and DNA damage kinase WEE1, increasing the vulnerability to WEE1 inhibition. Hence, the combination of MRT-92 with the WEE1 inhibitor AZD-1775 showed increased antitumor activity in vitro and in iCCA xenografts compared with single treatments. These data indicate that combined inhibition of SMO and WEE1 reduces tumor burden and may represent a strategy for the clinical development of novel therapeutic approaches in iCCA., Cholangiocarcinoma (CCA) is characterized by resistance to chemotherapy and a poor prognosis. Therefore, treatments that can effectively suppress tumor growth are urgently needed. Aberrant activation of hedgehog (HH) signaling has been implicated in several cancers, including those of the hepatobiliary tract. However, the role of HH signaling in intrahepatic CCA (iCCA) has not been completely elucidated. In this study, we addressed the function of the main transducer Smoothened (SMO) and the transcription factors (TFs) GLI1 and GLI2 in iCCA. In addition, we evaluated the potential benefits of the combined inhibition of SMO and the DNA damage kinase WEE1. Transcriptomic analysis of 152 human iCCA samples showed increased expression of GLI1, GLI2, and Patched 1 (PTCH1) in tumor tissues compared with nontumor tissues. Genetic silencing of SMO, GLI1, and GLI2 inhibited the growth, survival, invasiveness, and self-renewal of iCCA cells. Pharmacologic inhibition of SMO reduced iCCA growth and viability in vitro, by inducing double-strand break DNA damage, leading to mitotic arrest and apoptotic cell death. Importantly, SMO inhibition resulted in the activation of the G2-M checkpoint and DNA damage kinase WEE1, increasing the vulnerability to WEE1 inhibition. Hence, the combination of MRT-92 with the WEE1 inhibitor AZD-1775 showed increased antitumor activity in vitro and in iCCA xenografts compared with single treatments. These data indicate that combined inhibition of SMO and WEE1 reduces tumor burden and may represent a strategy for the clinical development of novel therapeutic approaches in iCCA.

Published
2023

189. A Bispecific Antibody to Link a TRAIL-Based Antitumor Approach to Immunotherapy

Author

Alessandro Satta, Giulia Grazia, Francesco Caroli, Barbara Frigerio, Massimo Di Nicola, Francesco Raspagliesi, Delia Mezzanzanica, Nadia Zaffaroni, Alessandro Massimo Gianni, Andrea Anichini, and Mariangela Figini

Subjects
bispecific antibody, TRAIL-R2, immunotherapy, T-cell retargeting, malignant ascites, Immunologic diseases. Allergy, RC581-607
Abstract

T-cell-based immunotherapy strategies have profoundly improved the clinical management of several solid tumors and hematological malignancies. A recently developed and promising immunotherapy approach is to redirect polyclonal MHC-unrestricted T lymphocytes toward cancer cells by bispecific antibodies (bsAbs) that engage the CD3 complex and a tumor-associated antigen (TAA). The TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) is an attractive immunotherapy target, frequently expressed by neoplastic cells, that we decided to exploit as a TAA. We found that a TRAIL-R2xCD3 bsAb efficiently activates T cells and specifically redirect their cytotoxicity against cancer cells of different origins in vitro, thereby demonstrating its potential as a pan-carcinoma reagent. Moreover, to mimic in vivo conditions, we assessed its ability to retarget T-cell activity in an ex vivo model of ovarian cancer patients' ascitic fluids containing both effector and target cells—albeit with a suboptimal effector-to-target ratio—with remarkable results.

Published
2019
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192. Data from Role of Apollon in Human Melanoma Resistance to Antitumor Agents That Activate the Intrinsic or the Extrinsic Apoptosis Pathways

Author

Andrea Anichini, Roberta Mortarini, Alessandro M. Gianni, Carmelo Carlo-Stella, Soldano Ferrone, Michele Milella, Nadia Zaffaroni, Marzia Pennati, Valentina Perotti, Ilaria Bersani, Alessandra Molla, Claudia Vegetti, Marina Zanon, and Elena Tassi

Abstract

Purpose: To assess the role of Apollon in melanoma resistance to intrinsic and extrinsic pathways of apoptosis and to identify strategies to reduce its expression.Experimental Design: Apollon expression was assessed in melanoma cells in vitro and in vivo. Apollon modulation and melanoma apoptosis were evaluated by Western blot and/or flow cytometry in response to cytotoxic drugs, mitogen-activated protein/extracellular signal–regulated kinase (MEK)-, BRAFV600E-, and mTOR-specific inhibitors, TRAIL and anti-HLA class II monoclonal antibodies (mAb). Mitochondrial depolarization, caspase activation, apoptosis assays, and gene expression profiling were used to test effects of Apollon silencing, by siRNA, on melanoma response to antitumor agents.Results: Apollon was constitutively expressed by melanoma cells, in vitro and in vivo, and at higher levels than in benign melanocytic lesions. Melanoma apoptosis correlated significantly with Apollon protein downmodulation in response to cytotoxic drugs, MEK, or BRAFV600E-specific inhibitors. Combinatorial treatment with MEK and mTOR inhibitors and HLA class II ligation, by a specific mAb, promoted Apollon downmodulation and enhanced melanoma apoptosis. Apollon downmodulation induced by antitumor agents was caspase independent, but proteasome dependent. Knockdown of Apollon, by siRNA, triggered apoptosis and/or significantly enhanced melanoma cell death in response to cytotoxic drugs, MEK- and BRAFV600E-specific inhibitors, and soluble or membrane-bound TRAIL. Apollon silencing promoted mitochondrial depolarization and caspase-2, caspase-8, caspase-9, and caspase-3 activation in response to different antitumor agents and altered the profile of genes modulated by MEK or BRAFV600E-specific inhibitors.Conclusions: Targeting of Apollon may significantly improve melanoma cell death in response to antitumor agents that trigger the intrinsic or the extrinsic apoptosis pathways. Clin Cancer Res; 18(12); 3316–27. ©2012 AACR.

Published
2023

193. Supplementary Figure 2 from IGKV3 Proteins as Candidate 'Off-the-Shelf' Vaccines for Kappa-Light Chain–Restricted B-Cell Non-Hodgkin Lymphomas

Author

Riccardo Dolcetti, Andrea Anichini, Antonio Rosato, Antonino Carbone, Mario Mazzucato, Daniela Gasparotto, Roberta Mortarini, Michele Spina, Luca Romagnoli, Laura Caggiari, Elisa Pasini, Anna Merlo, Riccardo Turrini, Elena Muraro, Valli De Re, Massimo Guidoboni, and Debora Martorelli

Abstract

PDF file, 331KB, Cross-reactive CTL responses elicited by native IGKV3-20 epitopes.

Published
2023

195. Supplementary Figure 1 from IGKV3 Proteins as Candidate 'Off-the-Shelf' Vaccines for Kappa-Light Chain–Restricted B-Cell Non-Hodgkin Lymphomas

Author

Riccardo Dolcetti, Andrea Anichini, Antonio Rosato, Antonino Carbone, Mario Mazzucato, Daniela Gasparotto, Roberta Mortarini, Michele Spina, Luca Romagnoli, Laura Caggiari, Elisa Pasini, Anna Merlo, Riccardo Turrini, Elena Muraro, Valli De Re, Massimo Guidoboni, and Debora Martorelli

Abstract

PDF file, 303KB, Serum antibody responses to the IGKV3-20 recombinant protein in IGKV3+ lymphoma patients and healthy donors assessed by a chemiluminescence ELISA. Data are expressed as the ratio between the relative fluorescence unit (RFU) of the IGKV3-20 and those of tetanus toxoid, as reference value of antibody memory response to an exogenous antigen. This approach has been chosen to limit the possible influence of tumor-related immune suppression.

Published
2023

196. Supplementary Figure 1 from Phase II Study of Perifosine and Sorafenib Dual-Targeted Therapy in Patients with Relapsed or Refractory Lymphoproliferative Diseases

Author

Alessandro M. Gianni, Paolo Corradini, Andrea Anichini, Massimo Di Nicola, Laura Giordano, Lucia Farina, Anna Dodero, Roberto Sorasio, Alfonso Marchianò, Domenico Russo, Simonetta Viviani, Roberta Mortarini, Walter Malorni, Silvia L. Locatelli, Carmelo Carlo-Stella, and Anna Guidetti

Abstract

Supplementary Figure 1. Represents CD30 serum levels at various time during the therapy in 22 patients

Published
2023

199. Supplementary Data from Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade

Author

Marina Chiara Garassino, Gabriella Sozzi, Andrea Balsari, Licia Rivoltini, Andrea Anichini, Mario Paolo Colombo, Claudio Tripodo, Valter Torri, Silvia Marsoni, Alberto Bardelli, Elena Tassi, Chiara Storti, Lucia Sfondrini, Sabina Sangaletti, Diego Signorelli, Giancarlo Pruneri, Claudia Proto, Luca Porcu, Massimo Milione, Veronica Huber, Patrizia Gasparini, Monica Ganzinelli, Simona Ferro, Giovanni Centonze, Mattia Boeri, Valeria Cancila, Michele Sommariva, Massimo Moro, and Giuseppe Lo Russo

Abstract

This files describes supplementary materials and methods

Published
2023

200. Supplementary Tables from Antibody–Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non–small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade

Author

Marina Chiara Garassino, Gabriella Sozzi, Andrea Balsari, Licia Rivoltini, Andrea Anichini, Mario Paolo Colombo, Claudio Tripodo, Valter Torri, Silvia Marsoni, Alberto Bardelli, Elena Tassi, Chiara Storti, Lucia Sfondrini, Sabina Sangaletti, Diego Signorelli, Giancarlo Pruneri, Claudia Proto, Luca Porcu, Massimo Milione, Veronica Huber, Patrizia Gasparini, Monica Ganzinelli, Simona Ferro, Giovanni Centonze, Mattia Boeri, Valeria Cancila, Michele Sommariva, Massimo Moro, and Giuseppe Lo Russo

Abstract

Supplementary Tables

Published
2023

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