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El presente informe tiene como objetivo describir las principales experiencias y lecciones aprendidas a través de la implementación de una "Acción Curricular en Comunidad y Sociedad (ACCS)" en el área de Medio Ambiente, titulada "Ciencia, comunicación y ciudadanía: Compromiso de la sociedad civil en acciones de conservación de la biodiversidad y servicios ecosistémicos", dirigida a estudiantes de pregrado de la Universidad Federal de Bahía (UFBA). A lo largo de los años en que se ha ofrecido, este componente curricular ha brindado a los estudiantes experiencias enriquecedoras y ha contribuido al fortalecimiento de la integración entre la enseñanza, la investigación y la extensión a través de diversas actividades, construyendo puentes entre la universidad y la sociedad, fortaleciendo la identidad colectiva, empoderando a las comunidades locales y aumentando la autoestima de los participantes. Basados en las lecciones aprendidas, buscamos reflexionar sobre las barreras que deben superarse para lograr una integración más amplia y cualificada de la Extensión Universitaria en los planes de estudios de pregrado y posgrado en nuestro país., O presente relato tem como objetivo descrever as principais vivências e experiências adquiridas por meio da oferta de uma "Ação Curricular em Comunidade e Sociedade (ACCS)", na área de Meio Ambiente, intitulada "Ciência, comunicação e cidadania: Engajamento da sociedade civil em ações de conservação da biodiversidade e serviços ecossistêmicos", destinada aos estudantes dos cursos de graduação da Universidade Federal da Bahia (UFBA). Ao longo dos anos em que foi ofertado, o componente curricular tem proporcionado aos estudantes vivências e experiências enriquecedoras, bem como, contribuído para o fortalecimento da articulação entre ensino, pesquisa e extensão, por meio das diversas atividades desenvolvidas, para a construção de pontes entre univeridade e sociedade, no fortalecimento da identidade coletiva, para o empoderamento das populações locais e para o aumento da autoestima dos envolvidos. Com base nas lições aprendidas, buscamos refletir sobre as barreiras que precisam ser superadas para que a inserção qualificada da Extensão Universitária nos currículos de graduação e pós-graduação ganhe uma maior abrangência em nosso país., This report aims to describe the main experiences and lessons learned from the implementation of a "Curricular Action in Community and Society (ACCS)" in the field of Environment, entitled "Science, Communication, and Citizenship: Engaging civil society in biodiversity conservation and ecosystem services actions," aimed at undergraduate students at the Federal University of Bahia (UFBA). Over the years it has been offered, this curricular component has provided students with enriching experiences and contributed to strengthening the integration between teaching, research, and extension through various activities, building bridges between the university and society, strengthening collective identity, empowering local communities, and enhancing self-esteem of them. Based on the lessons learned, we seek to reflect on the barriers that need to be overcome for a more widespread and qualified integration of University Extension into undergraduate and graduate curricula in our country.

Relatório anual de atividades da Women In Nuclear Brasil 2021

In biological systems, liquid and solid-like biomolecular condensates may contain the same molecules but their behaviour, including movement, elasticity and viscosity, is different on account of distinct physicochemical properties. As such, it is known that phase transitions affect the function of biological condensates and that material properties can be tuned by several factors including temperature, concentration and valency. It is, however, unclear if some factors are more efficient than others at regulating their behaviour. Viral infections are good systems to address this question as they form condensates de novo as part of their replication programmes. Here, we used influenza A virus liquid cytosolic condensates, A.K.A viral inclusions, to provide a proof of concept that liquid condensate hardening via changes in the valency of its components is more efficient than altering their concentration or the temperature of the cell. Liquid IAV inclusions may be hardened by targeting vRNP interactions via the known NP oligomerizing molecule, nucleozin, both in vitro and in vivo without affecting host proteome abundance nor solubility. This study is a starting point for understanding how to pharmacologically modulate the material properties of IAV inclusions and may offer opportunities for alternative antiviral strategies.

Presentation to the Workshop: Modelling the pathogenesis of COVID-19 using the Adverse Outcome Pathway (CIAO) February 2023 Search for CCTE records in EPA’s Science Inventory by typing in the title at this link. https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&DEID=&personName=&personID=&role=Any&journalName=&journalID=&publisherName=&publisherID=&sortBy=pubDate&count=25

Dissertação de mestrado integrado em Psicologia, A adolescência trata-se do período temporal no qual os jovens tomam consciência dos diferentes papéis inerentes à sociedade e constroem a sua própria identidade. Nesta fase desenvolvimental, as aspirações surgem como resultado da aquisição de competências, atitudes, valores e redes de contacto. Entre os múltiplos fatores que influenciam a formação de aspirações, o nível socioeconómico, a orientação dos adolescentes para o futuro e a influência e habilitações académicas dos pais foram as variáveis em estudo nesta investigação. O presente trabalho teve como principal objetivo compreender como as aspirações percebidas dos pais influenciam as aspirações - intrínsecas e extrínsecas - dos adolescentes. Utilizou-se a Escala das Aspirações Percebidas dos Pais, construída especificamente para este estudo. A amostra foi constituída por 91 adolescentes com idades compreendidas entre 13 e 21 anos (M = 16.15, DP = 2.47), cujas famílias beneficiam de apoios socias. Os resultados mostraram que a orientação para o futuro dos adolescentes, as aspirações percebidas dos pais e as suas habilitações académicas predizem as aspirações dos adolescentes. Estes resultados permitem compreender melhor as aspirações e a importância do suporte parental e da existência duma pessoa de referência na orientação para o futuro dos adolescentes, mesmo estando inseridos em contextos carenciados., Adolescence is the time period in which young people become aware of the different inherent roles in society and build their own identity. During this stage of development, aspirations emerge as a result of the acquisition of skills, attitudes, values and social networks. Among the multiple factors that influence the emergence of aspirations, the socioeconomic level, the adolescents’ future orientation and the parents’ influence and academic qualifications were the variables under study in this investigation. The main aim of this study was to understand how the parents’ perceived aspirations influence the - intrinsic and extrinsic - aspirations of adolescents. The Parents' Perceived Aspirations Scale, built specifically for this study, was used. The sample consisted of 91 adolescents in need aged between 13 and 21 years (M = 16.15, SD = 2.47), whose families benefit from social support. The results showed that adolescent’s future orientation and parents' perceived aspirations and educational qualifications predict adolescents' aspirations. These results allow us to better understand aspirations and the importance of parental support and a role model to the future orientation of adolescents, even when they are in poor environments.

Multiple viral infections form biomolecular condensates in the host cell to compartmentalize viral reactions. Accumulating evidence indicates that these viral condensates may be hardened, a strategy with potential for exploitation as novel antiviral therapy, given that viral reactions rely on specific material properties for function. However, there is no molecular understanding on how to specifically and efficiently modify the material properties of viral condensates in vivo, a pre-requisite for overcoming off-target effects by rational drug design. In vitro, the material properties of biological condensates are modified by different thermodynamic parameters, including free energy, concentration, and type/strength of interactions. Here, we used influenza A virus liquid cytosolic condensates, A.K.A viral inclusions, to provide a proof of concept that modulating the type/strength of transient interactions among the interactome in IAV inclusions is more efficient at hardening these structures than varying the temperature or concentration, both in in vitro and in in vivo models. This stabilization can be achieved by a known pharmacological sticker that can specifically change the material properties of viral inclusions without affecting host proteome abundance nor solubility. Our work supports the development of antivirals targeting the material properties of biomolecular condensates in viral infections. It also provides a framework for the selection of compounds with this activity for general application and thus provides an advance in disease therapy.

Multiple viral infections form biomolecular condensates in the host cell to compartmentalize viral reactions. Accumulating evidence indicates that these viral condensates may be hardened, a strategy with the potential for exploitation as novel antiviral therapy, given that viral reactions rely on specific material properties for function. However, there is no molecular understanding of how to specifically and efficiently modify the material properties of viral condensates in vivo, a prerequisite for overcoming off-target effects by rational drug design. In vitro, the material properties of biological condensates are modified by different thermodynamic parameters, including free energy, concentration, and type/strength of interactions. Here, we used influenza A virus liquid cytosolic condensates, A.K.A viral inclusions, to provide a proof of concept that modulating the type/strength of transient interactions among the interactome in IAV inclusions is more efficient at hardening these structures than varying the temperature or concentration, both in in vitro and in in vivo models. This stabilization can be achieved by a known pharmacological sticker that, in addition, can specifically change the solubility of the viral proteome without affecting host proteome abundance nor solubility. Our work supports the development of antivirals targeting the material properties of biomolecular condensates in viral infections. It also provides a framework for the selection of compounds with this activity for general application and thus provides an advance in disease therapy.

Funding: This research was funded by Fundação para a Ciência e Tecnologia through CEECIND/01049/ 2020 for H.S. and CEECIND/02373/2020 for M.-J.A. For the other authors, this research received no external funding. The gut has been proposed as a potential alternative entry route for SARS-CoV-2. This was mainly based on the high levels of SARS-CoV-2 receptor expressed in the gastrointestinal (GI) tract, the observations of GI disorders (such as diarrhea) in some COVID-19 patients and the detection of SARS-CoV-2 RNA in feces. However, the underlying mechanisms remain poorly understood. It has been proposed that SARS-CoV-2 can productively infect enterocytes, damaging the intestinal barrier and contributing to inflammatory response, which might lead to GI manifestations, including diarrhea. Here, we report a methodological approach to assess the evidence supporting the sequence of events driving SARS-CoV-2 enteric infection up to gut adverse outcomes. Exploring evidence permits to highlight knowledge gaps and current inconsistencies in the literature and to guide further research. Based on the current insights on SARS-CoV-2 intestinal infection and transmission, we then discuss the potential implication on clinical practice, including on long COVID. A better understanding of the GI implication in COVID-19 is still needed to improve disease management and could help identify innovative therapies or preventive actions targeting the GI tract. publishersversion published

Large amounts of oil are trapped in the wells after primary extraction. To solve this problem, advanced oil extraction methods were developed. The present study mapped the use of glycerin and soapstock, biodiesel by-products, as injection fluids to increase the recovery factor of mature wells. Questel Orbit was the database used in prospecting, where combinations of key words with international classification codes were used associated with the use of surfactants as EOR fluids, in particular crude glycerin and soapstock. The search for articles was carried out using the advanced search for keywords on the Elsevier platform. The results were thirty-one patentes and 107 articles related, where observed a diffusion of Technologies from 2015 and trends in development in China, the United States and Brazil. Greater dissemination of the theme was noted in countries that are major oil and biodiesel producers, in addition to observing the need for greater investments in the area, in order to provide economic, social and sustainable development. Grandes quantidades de petróleo ficam retidas nos poços após recuperação primária. Para resolver esse problema, métodos avançados de extração de óleo foram desenvolvidos. O presente estudo mapeou o uso de glicerina e soapstock, subprodutos do biodiesel, como fluidos de injeção para aumentar o fator de recuperação de poços maduros. Utilizou-se o Quest Orbit na busca de patentes, fazendo uso de combinações de palavras com código de classificação internacional associados ao uso de surfactantes como fluídos EOR, em especial a glicerina bruta e o soapstock. As buscas de artigos foram feitas na plataforma Elsevier. Os resultados foram 31 patentes e 107 artigos relacionados, nos quais se observou a difusão das tecnologias a partir de 2015 e as tendências ao desenvolvimento na China, Estados Unidos e Brasil. Notou-se maior difusão do tema em países produtores de petróleo e biodiesel, além de observar a necessidade de maiores investimentos na área, a fim de proporcionar desenvolvimento econômico, social e sustentável.