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In this paper we show that a strongly homotopy commutative (or C∞-) algebra with an invariant inner product on its cohomology can be uniquely extended to a symplectic C∞-algebra (an ∞-generalisation of a commutative Frobenius algebra introduced by Kontsevich). This result relies on the algebraic Hodge decomposition of the cyclic Hochschild cohomology of a C∞-algebra and does not generalize to algebras over other operads.

Background Infectious Pancreatic Necrosis (IPN) is a highly contagious birnavirus disease of farmed salmonid fish, which often causes high levels of morbidity and mortality. A large host genetic component to resistance has been previously described for Atlantic salmon (Salmo salar L.), which mediates high mortality rates in some families and zero mortality in others. However, the molecular and immunological basis for this resistance is not yet fully known. This manuscript describes a global comparison of the gene expression profiles of resistant and susceptible Atlantic salmon fry following challenge with the IPN virus. Results Salmon fry from two IPNV-resistant and two IPNV-susceptible full sibling families were challenged with the virus and sampled at 1 day, 7 days and 20 days post-challenge. Significant viral titre was observed in both resistant and susceptible fish at all timepoints, although generally at higher levels in susceptible fish. Gene expression profiles combined with gene ontology and pathway analyses demonstrated that while a clear immune response was observed in both resistant and susceptible fish, there were striking differences between the two phenotypes. The susceptible fish showed marked up-regulation of genes related to cytokine activity and inflammatory response that evidently failed to protect against the virus. In contrast, the resistant fish demonstrated a less pronounced immune response including up-regulation of genes relating to the M2 macrophage system. Conclusions While only the susceptible phenotype shows appreciable mortality levels, both resistant and susceptible fish can become infected with IPNV. Susceptible fish are characterized by a much larger, yet ineffective, immune response, largely related to cytokine and inflammatory systems. Resistant fish demonstrate a more moderate, putative macrophage-mediated inflammatory response, which may contribute to their survival. Electronic supplementary material The online version of this article (doi:10.1186/s12864-016-2600-y) contains supplementary material, which is available to authorized users.

Myeloma is one of the most common malignancies that results in osteolytic lesions of the spine. Complications, including pathological fractures of the vertebrae and spinal cord compression, may cause severe pain, deformity and neurological sequelae. They may also have significant consequences for quality of life and prognosis for patients. For patients with known or newly diagnosed myeloma presenting with persistent back or radicular pain/weakness, early diagnosis of spinal myeloma disease is therefore essential to treat and prevent further deterioration. Magnetic resonance imaging is the initial imaging modality of choice for the evaluation of spinal disease. Treatment of the underlying malignancy with systemic chemotherapy together with supportive bisphosphonate treatment reduces further vertebral damage. Additional interventions such as cement augmentation, radiotherapy, or surgery are often necessary to prevent, treat and control spinal complications. However, optimal management is dependent on the individual nature of the spinal involvement and requires careful assessment and appropriate intervention throughout. This article reviews the treatment and management options for spinal myeloma disease and highlights the value of defined pathways to enable the proper management of patients affected by it.

In this paper we discuss two constructions of an effective field theory starting from a local interaction functional. One relies on the well-established graphical combinatorics of the BPHZ algorithm to renormalize divergent Feynman amplitudes. The other, more recent and due to Costello, relies on an inductive construction of local counterterms that uses no graphical combinatorics whatsoever. We show that these two constructions produce the same effective field theory., Comment: 20 pages, 1 figure

Summary The Schiehallion field has experienced many reservoir management challenges since first production in 1998. Dynamic data such as formation pressures, pressure-transient analysis, interference testing, tracer analysis, and 4D seismic need to be interpreted with great care—Schiehallion has examples in which the data have been invaluable and others in which the data are ambiguous or misleading. It is essential to integrate several data types to obtain reliable conclusions. This paper describes some of the highlights and pitfalls experienced in Schiehallion.

In this paper we will prove a super-analogue of a well-known result by Kontsevich which states that the homology of a certain complex which is generated by isomorphism classes of oriented graphs can be calculated as the Lie algebra homology of an infinite-dimensional Lie algebra of symplectic vector fields., Comment: 15 pages

In this paper we prove the existence and uniqueness of a topological quantum field theory that incorporates, for all Riemann surfaces, the corresponding spaces of theta functions and the actions of the Heisenberg groups and modular groups on them., Comment: 23 pages, 11 figures

Summary Genetic variation in performance and quality traits measured at harvest has previously been demonstrated in Atlantic salmon aquaculture populations. To map major loci underlying this variation, we utilized data from 10 families from a commercial breeding programme. Significant QTL were detected affecting harvest weight and length traits on linkage group 1, and affecting waste weight on linkage group 5. In total, 11 of the 29 linkage groups examined showed at least suggestive evidence for a QTL. These data suggest that major loci affecting economically important harvest characteristics are segregating in commercial salmon populations.