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151. Comparing diagnostic tools in personality disorders.

Author

Aktas, Emel, Guriz, Olga Seher, Alpaslan, Guler, Cavdar, Esra, and Orsel, Sibel

Subjects
*PERSONALITY disorders, *PATHOLOGICAL psychology, *PERSONALITY tests, *EMOTIONS, *CONSCIOUSNESS
Abstract

Objective: Personality disorders involve patterns of behavior, mood, social interaction and impulsiveness that cause distress to the person experiencing them as well as to other people in their lives. DSM-IV-TR Personality Disorder categorical classification includes ten different personality disorders defined as cluster A, paranoid, schizoid, schizotypal, cluster B, histrionic, narcissistic, borderline, antisocial, cluster C avoidant, dependent, and obsessive-compulsive. In clinical settings, diagnosing personality disorders is essential for planning treatment, especially in treatment non-adherence and resistant groups. There are no measurable advantages for clinicianbased interview techniques as being more reliable and valid than self-report questionnaires, and both of the techniques are used. We aimed to compare SCID-2 (Structured Clinical Interview for DSM-IV Personality Disorder) with self-report questionnaires PBQ (Personality Belief Questionnaire) and MMPI-PD (Minnesota Multiphasic Personality Inventory) to determine consistency of these diagnostic tools in this study. Methods: The participating thirty-nine patients were hospitalized at Ankara Diskapı Yildirim Beyazit Training and Research Hospital and Etlik Expert Hospital of Psychiatry Clinic; they were older than 18 years, literate, and had been diagnosed with personality disorder based on SCID-2 interview. Psychotic disorders were excluded. Socio-demographic data form, MMPI-PD, and PBQ were used. For data evaluation, non-parametric tests were used for descriptive statistics and Spearman correlation analysis for the relationship between tools. Results: Thirty-nine patients met the inclusion criteria; of these, 19 (48.7%) were female, 20 (51.3%) were male. Mean age was 38.1±11.08. SCID-II diagnoses were clustered A, B, C for statistical evaluation. We found cluster B (61.5%) and borderline personality disorder were the most frequent (13 patients- 33.3%). The results of correlation analysis were statistically significant between self-report questionnaires PBQ, MMPI-PD and SCID-II for the correlation between PBQ-histrionic subscale and cluster B (r=0.34) and correlation between PBQ-antisocial and cluster C (r=-0.34). Comparing SCID-II personality disorder clusters with MMPI- PD subscales, moderate significant correlation has been obtained between cluster A and MMPI-PD paranoia subscale (r=0.50). Statistically significant correlation was not determined between other subscales. Conclusion: In this study we aimed to compare diagnostic compatibility between self-report questionnaires PBQ, MMPI-PD and semistructured interview SCID-II. In an epidemiological study in Turkey, the prevalence of cluster A was found to be 7.7%, cluster B 4.1%, and cluster C 6.5%; in an outpatient setting it is reported that using PBQ (Personality Diagnostic Questionnaire) found high frequency in cluster C and low in cluster B. Hayward at al. showed that the most common personality disorder was cluster B personality disorder in patients diagnosed with axis 1 disorders. Similarly we found cluster B higher; this might reflect the fact that the participants were inpatients and co-morbid with axis 1 disorders. In conclusion, correlation between self-report questionnaires and interview techniques has been found low and reached different results in diagnosing personality disorders. More comprehensive studies are required to develop diagnostic tools for personality disorders. [ABSTRACT FROM AUTHOR]

Published
2015

152. A Multi-Attribute Decision-Making Model for Hospital Location Selection

Author

İmamoğlu, Gül, Topcu, Y. Ilker, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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153. Exploring the Third Wave of Feminism Through Hierarchical Clustering and Sentiment Analysis

Author

Ay, Hüseyin Umutcan, Günesen, Semra Nazlı, Kaya, Tolga, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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154. Communicating Value in Healthcare Marketing from a Social Media Perspective

Author

Çağlıyor, Sandy, Tosun, Petek, Uray, Nimet, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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155. On the Principle of Lagrange in Optimization Theory and Its Application in Transportation and Location Problems

Author

Frenk, J. B. G., Javadi, Sonya, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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156. Measuring Foreign Trade-Logistics Efficiency: A DEA Approach and the Malmquist Index

Author

Acar, Mehmet Fatih, Özer Torgalöz, Alev, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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157. Competitiveness of Nations and Inequality-Adjusted Human Development: Evaluating the Efficiency of Nations Using DEA and Random Forest Classification

Author

Campbell, Christopher Colin, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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158. A Comparative Analysis of Forecasting Models on COVID-19

Author

Erol Genevois, Müjde, Cedolin, Michele, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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159. Partially Non-discretionary Measures for Green Transportation Corridors Performance Index: A DEA Approach

Author

Costa Melo, Isotilia, Nocera Alves Junior, Paulo, Péra, Thiago Guilherme, Aparecida Do Nascimento Rebelatto, Daisy, Vicente Caixeta-Filho, José, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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160. The Role of Logistics Management in Food Supply Chains

Author

dos Reis, João Gilberto Mendes, Machado, Sivanilza Teixeira, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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161. Analyzing the Interaction of Renewable Energy Penetration with the Wealth of Nations Using Bayesian Nets

Author

Isik, Mine, Özaydın, Özay, Ekici, Şule Önsel, Topcu, Y. Ilker, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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162. A New Paradigm of Transport in the Wake of a New Age?

Author

Candemir, Yücel, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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163. Picture Fuzzy Extension of DEMATEL and its Usage in Educational Quality Evaluation

Author

Gül, Sait, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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164. Determining the Priority of University Technology Transfer Office Activities for Each Group of the Stakeholder Using SWARA Method

Author

Karadayi, Melis Almula, Ekinci, Yeliz, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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165. A Contingency Approach to Multi-Criteria Decision-Making: A Search for Validity Through Rigor and Relevance

Author

Mu, Enrique, Cooper, Orrin, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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166. A Multi-Criteria Decision-Making Approach for Hazmat Transportation

Author

Yilmaz, Zafer, Verter, Vedat, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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167. Strategic Multi-criteria Decision-Making Against Pandemics Using Picture and Spherical Fuzzy AHP and TOPSIS

Author

Kahraman, Cengiz, Ucal Sari, Irem, Çevik Onar, Sezi, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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168. The Status Granted to Organizational Identity Characteristics: An Application of the Best-Worst Method and Regression Analysis

Author

Topaler, Başak, Çavdaroğlu, Nur Ayvaz, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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169. The Skill Wage Premium in the Turkish Labor Market from The Race Between Technology and Education Perspective

Author

Eriş Dereli, Bilge, Erkol, Narod, Levent, Haluk, Zeki Orbay, Benan, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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170. Fair Assignment of Debt Cases to Legal Debt Collection Centers

Author

Farrokhizadeh, Elmira, Ghazanfari Khameneh, Sara, Altinok, Nilüfer, Tekin, Ahmet Tezcan, Oztaysi, Basar, Kabak, Özgür, Çevik Onar, Sezi, Tari, Aslıhan Ceren, Gencer Aydemir, Özge, Öztürk, Ersan, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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171. The European Survey on OR/MS Education: Statistical Analysis Addressing the Lecturing Modules

Author

Teixeira, Ana Paula, de Miranda, João Luís, Pato, Margarida Vaz, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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172. From E-Satisfaction to E-Repurchase Intention: How Is E-Repurchase Intention Mediated by E-Satisfaction and Moderated by Traditional Shopping Attitudes?

Author

Demirbaş, Esra, Gültekin Salman, Gülberk, Uray, Nimet, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L, Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, Topcu, Y. Ilker, editor, Önsel Ekici, Şule, editor, Kabak, Özgür, editor, Aktas, Emel, editor, and Özaydın, Özay, editor

Published
2022
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183. Urban Vehicle Access Regulations

Author

Lopez, Osvaldo Navarro, Sharda, Ramesh, Series Editor, Voß, Stefan, Series Editor, Zeimpekis, Vasileios, editor, Aktas, Emel, editor, Bourlakis, Michael, editor, and Minis, Ioannis, editor

Published
2018
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191. On the Principle of Lagrange in Optimization Theory and Its Application in Transportation and Location Problems

Author

Frenk, Hans, Javadi Khatab, Sonya, Topçu, İlker, Önsel Ekici, Şule, Kabak, Özgür, Aktas, Emel, and Özaydın, Özay

Abstract

In mathematical optimzation, the Lagrangian approach is a general method to find an optimal solution of a finite( infinite) dimensional constrained continuous optimization problem. This method has beeen introduced by the Italian mathematician Joseph-Louıs Lagrange in 1775 in a series of letters to Euler.This approach became known under the name the principle of Lagrange and was also applied much later to integer programming problems The basic idea behind this method is to replace a constraianed optimization problem by a sequence of easier solvable optimzation probelems having fewer constraints and penalizing the deletıon of the original constraints by replacing the original objective function. To select the best penalization,the so-called Lagrangian dual function needs to be optimized and a possible algorithm to do so is called the subgradient algorithm. This method is discussed in detail at the end of this chapter.The Lagrangian approach led to the introduction of dual optimization problems in nonlinear programming and recently to the development of interior point methods and the identification of polynomially solvable casses of continuous optimiAlso it had its impact on how to construct algorithms to generate approximate solutions of integer programming problems.In this chapter, we discuss in the first part the main ideas behind this approach for any type of finite dimensional optimization problem. In the remaining parts of this chapter we focus in more detail how this approach is used in continuous optimization problems and show its full impact on the so-called K-convex continuous optimzation problems. Also we consider its application within linear integer programming problems and show how it is used to solve these type of problems. To illustrate its application to the well-known integer programming problems we consider in the final section its application to some vehicle routing and location models. As such this chapter shouldf be regarded as an introduction to duality theory for less mathematically oriented readers proving at the same time most of the results using the simplest possible proofs.

Published
2021
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192. In search of a human dimension of Supply Chain 4.0:Stipulating learning as a lever for the future supply chain organisation

Author

de Haas, Henning, Andersen, Søren Skjold, Mathiasen, John Bang, Tambo, Torben, Aktas, Emel, Bourlakis, Michael, Minis, Ioannis, and Zeimpekis, Vasilis

Subjects
Learning, Empowerment, Digital Transformation, Self-lead organisations, Learning supply chains
Abstract

Background and Aim: Supply Chain 4.0 (SCM 4.0) sets the agenda for a digitised transformation of Supply Chain Management (SCM). Digitalisation of SCM, entailing integration and transparency of data and information enables new opportunities for operational efficiencies, sustainability and new business models. However, we claim that the current managerial approach is a leftover from the industry 2.0 era in which data and information remain in functional silos. Accordingly, we aim at improving the understanding of how learning in SCM can be a lever for the ongoing transformation to SCM 4.0.Research Design and Methods: Besides a literature review on Supply Chain and Learning and Leadership, this chapter draws on a case of an assembly style of production, where products are transported to the construction site and assembled.Findings: Our empirical findings indicate that human learning is critical to any SCM organisation. The case provides an example of how new digital tools for communication can facilitate a learning and self-leading organisation as the answer to cope with the supply chain complexity in a SCM 4.0 paradigm. Theoretically, SCM 4.0 technology is described as cognitive or self-configuring. The prevalent understanding is that the majority of the managerial actions in the supply chain is performed without human involvement. However, our empirical findings show the opposite; we illustrate how the technological development influences the managerial approach in SCM, and how supply chain learning can be a balancing lever for SCM 4.0 to empower organisations to adapt new technologies and ensure the right application of new digitised tools and processes.Research Limitations: A single case study sets some limitations to the generalisability of our findings.Theoretical Contribution: While the SCM 4.0 literature brings technology to the fore, this chapter illustrates that supply chain learning is the lever for balancing technological and business opportunities; i.e., transforming the SCM into the digitised era calls for learning in supply chain processes, structures and managerial approaches.Practical impact: This chapter outlines dilemmas in the SCM 4.0 technology fascination and the lack of human focus, and suggests guiding principles for practitioners and decision makers on how to emphasise the learning dimension in the supply chain.Social impact: Future supply chain must be designed to provide opportunities for practitioners to develop their personal mastery and mental models, if the organisations should be socially justified. The skill and learning dimension are the social glue for the supply chain.

Published
2021

193. Serious Games as a Validation Tool for PREDIS: A Decision Support System for Disaster Management.

Author

Rye S and Aktas E

Subjects
Humans, Computer Simulation, Decision Making, Disasters, Disaster Planning
Abstract

In this paper, we validate PREDIS, a decision support system for disaster management using serious games to collect experts' judgments on its performance. PREDIS is a model for DISaster response supplier selection (PREDIS). It has a PREDictive component (PRED) for predicting the disaster human impact and an estimation component to Estimate the DISaster (EDIS) needs to optimise supplier-based resource allocation. A quasi-experiment design embedded in a participatory simulation game is conducted to compare the opinions of equal samples of 22 experts and non-experts. The following questions are put forward. First, "Does PREDIS model assists the decision makers to make the same decisions faster?" Second, "Does the PREDIS model assist the non-experts as simulated decision makers to decide like an expert?" Using AHP weights of decision makers' preferences as well as Borda counts, the decisions are compared. The result shows that PREDIS helps to reduce the decision-making time by experts and non-experts to 6 h after the disaster strike, instead of the usual 72 h. It also assists 71% of the non-experts to make decisions similar to those made by experts. In summary, the PREDIS model has two major capabilities. It enables the experts and non-experts to predict the disaster results immediately using widely available data. It also enables the non-experts to decide almost the same as the experts; either in predicting the human impact of a disaster and estimating the needs or in selecting suitable suppliers.

Published
2022
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194. Anti-Apoptotic and Anti-Oxidant Effects of Caffeic Acid Phenethyl Ester on Cadmium-Induced Testicular Toxicity in Rats.

Author

Erboga M, Kanter M, Aktas C, Bozdemir Donmez Y, Fidanol Erboga Z, Aktas E, and Gurel A

Subjects
Animals, Male, Oxidative Stress drug effects, Phenylethyl Alcohol pharmacology, Rats, Rats, Wistar, Testis metabolism, Antioxidants pharmacology, Apoptosis drug effects, Cadmium toxicity, Caffeic Acids pharmacology, Phenylethyl Alcohol analogs & derivatives, Testis drug effects, Testis pathology
Abstract

Cadmium (Cd) is a serious environmental and occupational contaminant and may represent a serious health hazard to humans and other animals. Cd is reported to induce the generation of reactive oxygen species, and induces testicular damage in many species of animals. The goal of our study was to examine the anti-apoptotic and anti-oxidant effects of caffeic acid phenethyl ester (CAPE) on Cd-induced oxidative stress, apoptosis, and testicular injury in rats. A total of 40 male Wistar albino rats were divided into four groups: control, CAPE alone, Cd-treated, and Cd-treated with CAPE; each group consisted of 10 animals. To induce toxicity, Cd (1 mg/kg body weight) was dissolved in normal saline and subcutaneously injected into rats for 30 days. The rats in CAPE-treated group were given a daily dose of 10 μmol/kg body weight of CAPE by using intraperitoneal injection. This application was continued daily for a total of 30 days. To date, no examinations of the anti-apoptotic and anti-oxidant properties of CAPE on Cd-induced apoptosis, oxidative damage, and testicular injury in rat testes have been reported. CAPE-treated animals showed an improved histological appearance and serum testosterone levels in Cd-treated group. Our data indicate a significant reduction in the number of apoptotic cells in testis tissues of the Cd-treated group with CAPE treatment. Moreover, CAPE significantly suppressed lipid peroxidation, compensated deficits in the anti-oxidant defenses in testes tissue resulted from Cd administration. These findings suggest that the protective potential of CAPE in Cd toxicity might be due to its anti-oxidant and anti-apoptotic properties, which could be useful for achieving optimum effects in Cd-induced testicular injury.

Published
2016
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