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This study presents a simple, low-cost, and efficient route to obtain zinc oxide by adopting the thermal decomposition method of zinc acetate at 300 (Gr@ZnO_300), 400 (Gr@ZnO_400), 500 (Gr@ZnO_500), and 600 °C (Gr@ZnO_600) for 1 h. The diffraction patterns collected for the samples indicated the majority formation of the hexagonal phase (P63mc) for zinc oxide and residual amounts for graphitic carbon, which has a hexagonal structure of space group P63/mmc. The images collected by scanning electron microscopy (SEM) revealed the formation of sub-microcrystals with elongated rod-shaped morphology, with dimensions between 0.223 and 1.09 μm. The optical and colourimetric properties of the obtained materials indicate the presence of graphitic carbon in the samples, corroborating the analysis by XRD and Raman spectroscopy, with an optical bandgap close to 3.21 eV, and energies of the valence (EVB) and conduction (ECB) bands of 2.89 eV and −0.31 eV, respectively. The photocatalytic performance at 20 min of exposure time under UV light of all prepared samples in the decolourisation of rhodamine B (RhB) dye solutions follows the order Gr@ZnO_300 (95.6%) > Gr@ZnO_600 (92.8%) > Gr@ZnO_400 (84.0%) > Gr@ZnO_500 (78.1%), where the photocatalytic performance of Gr@ZnO_300 sample was 16.5 times more effective than the photolysis test. Moreover, the results confirmed that the best performance was archived at pH = 10, and the holes (h+) and superoxide (O2•−) radicals are the main species involved in the discolouration of RhB dye molecules in an aqueous medium. Finally, the reusability experiment shows high stability of the Gr@ZnO_300 sample as a solid photocatalyst and cycling capability, which obtained total discolouration of RhB of a solution under five cycling experiments of 60 min of exposure to UV light at room temperature.

Introduction: Esophageal inflammatory diseases are frequent diagnoses in clinical practice and have diverse etiologies, the most common being those associated with the exposure to gastric content, drugs and allergens. In diseases, the immunological component is well identified in endoscopic biopsies, which mainly contain the epithelium and the lamina propria; however, deeper layers are less studied. Moreover, the esophageal capacity of sensing luminal compounds is poorly understood. Methods: In transmural sections from proximal, middle and distal esophagus obtained from deceased patients, we performed a phenotypic analysis of the main immune cell populations and acid-sensing receptors by immunohistochemistry and immunofluorescence methods. Results: A total of nine donors were studied (absence of pathology, optimal tissue preservation and orientation). We found the following: (1) the vascular papillae and the lamina propria are the most infiltrated layers by the lymphoid lineage (T and B lymphocytes), followed by the epithelium, while the smooth muscular layers are mainly populated by the myeloid lineage (macrophages and mast cells); (2) intraepithelial macrophages are consistently found along the esophagus; and (3) eosinophils are absent in all the esophageal layers. The acid-sensing receptors ASIC-1, ASIC-2 and δENAC are expressed in the esophageal epithelium and in the lamina propria, yet only ASIC-2 is expressed in the muscularis mucosae. Conclusions: The human esophagus contains a differential distribution of immune cells and acid-sensing receptors across its layers. This study extends the esophageal histological knowledge previously described and reinforces its role as a defensive and sensing organ.

Therapeutic monitoring of antibiotics and antifungals based on pharmacokinetic and pharmacodynamic (PK/PD) parameters is a strategy increasingly used for the optimization of therapy to improve efficacy, reduce the occurrence of toxicities, and prevent the selection of antimicrobial resistance, particularly in vulnerable patients including neonates and the critical or immunocompromised paediatric host.In neonates and children, infections account for a high percentage of hospital admissions, and anti-infectives are the most used drugs. However, paediatric PK/PD studies and the evidence regarding the efficacy and safety of some newly marketed antibiotics and antifungals—usually used off-label in paediatrics—to determine the optimal drug dosage regimens are limited. It is widely known that this population presents important differences in the PK parameters (especially in drug clearance and volume of distribution) in comparison with adults that may alter antimicrobial exposure and, therefore, compromise treatment success. In addition, paediatric patients are more susceptible to potential adverse drug effects and they need closer monitoring.The aim of this document, developed jointly by the Spanish Society of Hospital Pharmacy and the Spanish Society of Paediatric Infectious Diseases, is to describe the available evidence on the indications for therapeutic drug monitoring (TDM) of antibiotics and antifungals in newborn and paediatric patients, and to provide practical recommendations for TDM in routine clinical practice to optimise their dosing, efficacy and safety. Of antibiotics and antifungals in the paediatric population. Resumen: La monitorización terapéutica de antibióticos y antifúngicos en el paciente pediátrico, basada en parámetros farmacocinéticos y farmacodinámicos (PK/PD), es una estrategia cada vez más utilizada para la optimización del tratamiento de infecciones con el fin de mejorar la eficacia, reducir la aparición de toxicidades y prevenir la selección de resistencias antimicrobianas, especialmente en poblaciones vulnerables como neonatos, pacientes críticos o inmunodeprimidos.En la población neonatal y pediátrica, las infecciones representan un porcentaje elevado de los ingresos hospitalarios, siendo los antimicrobianos los fármacos más utilizados en este grupo poblacional. Sin embargo, establecer los regímenes posológicos óptimos en esta población es complejo debido a la menor evidencia respecto a la eficacia y seguridad de algunos antimicrobianos, especialmente en los de reciente comercialización que son utilizados habitualmente fuera de ficha técnica y al limitado número de estudios PK/PD disponibles en pediatría. Es bien conocido que el paciente pediátrico se caracteriza por presentar una serie de variaciones de los parámetros farmacocinéticos (como el aclaramiento o el volumen de distribución) debido a los propios cambios madurativos que pueden modificar la exposición a los antimicrobianos y comprometer el éxito del tratamiento. A su vez, es un grupo poblacional más susceptible a presentar potenciales efectos adversos a los fármacos, hecho que conlleva la necesidad de una monitorización más estricta.El objetivo de este documento de consenso, elaborado entre la Sociedad Española de Farmacia Hospitalaria (SEFH) y Sociedad Española de Infectología Pediátrica (SEIP), es describir la evidencia disponible sobre las indicaciones de la monitorización terapéutica de antibióticos y antifúngicos en pacientes neonatales y pediátricos, y proporcionar recomendaciones prácticas para su monitorización y ajuste de dosis, con el fin de optimizar el tratamiento, maximizando su eficacia y seguridad.

Abstract The development of quantum computers poses a risk to the cryptographic algorithms utilized by current public key infrastructure (PKI). High performance computing (HPC), inter- and intra-datacenter communications, and governmental communications are particularly vulnerable to security attacks by quantum computers. In response, there are on-going efforts on implementing post-quantum cryptography (PQC) despite the considerable overhead involved in processing PQC encrypted data packets in comparison with their classical counterparts. This work aims to help with the transition to quantum resistant cryptographic schemes by means of providing a thorough experimental performance comparison of the four algorithms selected by the National Institute of Standards and Technology (NIST) for standardization when implemented in a data processing unit (DPU). The experiments are conducted at line-rate, demonstrating for the first time operation at almost 100 Gbit/s and hence suitability for high-capacity data center environments.

La gestión del agua potable en zonas urbanas representa en la actualidad uno de los mayores desafíos. Por lo tanto, el suministro de agua potable y el saneamiento ha llevado a los expertos a explorar nuevos enfoques y estrategias para su gestión. Ubicándose en esta línea de trabajo, el presente documento explora los indicadores de evaluación de desempeño para la gestión del recurso hídrico aplicados a los servicios de abastecimiento de agua a nivel nacional e internacional. El objetivo consiste en proponer indicadores relacionados con los enfoques de gestión del agua orientados al derecho humano al agua y a un medio ambiente sano, y armonizando con el ODS-6 se plantea evaluar tanto los indicadores cualitativos como cuantitativos a través de una revisión de la literatura y criterios de selección, como aplicabilidad, relevancia, datos existentes y características locales de manejo que le dan al recurso hídrico. Aplicando al estudio de caso el Sistema de Agua Potable y Alcantarillado de León, Guanajuato (SAPAL), la investigación aplicó la metodología análisis jerárquico de procesos (AHP), indicando aquellos indicadores relevantes para la gestión del recurso hídrico bajo la perspectiva de soluciones multidisciplinares, integrales y sostenibles para el servicio de abastecimiento de agua, con lo cual pudo verificarse la disponibilidad de datos para la aplicación de los indicadores propuestos. Se concluye que a partir de este planteamiento se cuenta con indicadores que consideren los enfoques en materia socioambiental que impacten en la gestión sostenible del agua de manera que coadyuve al diseño, seguimiento, evaluación y toma de decisiones de políticas públicas enfocadas a los organismos operadores de manera integral.

The purpose of this article was to examine the effects of having an academic or student affairs professional mentor on working-class first-generation students' sense of belonging and resilience. The authors used propensity score matching techniques to develop matched pairs of working-class first-generation students who did and did not have a mentor. The results suggest that working-class first-generation students who had an academic or student affairs professional mentor had a significantly higher sense of belonging and resilience.

This paper deal about a fuzzy PI tuning from process image-based control system (IBC) for electric drives of hydro-mixture transport, which method use a [r g b] matrix as control vector from process images taken through a inferential sensor of density, to evaluation efficiency in electric drives for hydro-transport of laterite pulp with centrifugal pumps.

Introduction: The principal group of people who suffer from fragility hip fractures is the elderly population, gaining relevance given the increase in the average median age of the Chilean and European populations. This fracture risk is associated with a decreased bone density. Physical activity is a protective factor in the risk of falls and a determinant of bone resistance. Objectives: Determine the impact of physical activity on the probability of suffering a fragility hip fracture in a population ≥ 60 years of age in a public trauma hospital in Chile. Materials and methods: It was conducted a relational analytical study of cases and controls. A total of 147 patients participated, the case group with osteoporosis hip fracture formed for 72 patients, and the control group without hip fracture 75 patients formed for 75 patients. To quantify physical activity was applied the instrument Global Physical Activity Questionnaire in the control group, and a designed version to assess pre-fracture physical activity in the case group. Results: There is a significant statistical difference between the incidence of hip fractures and physical activity during leisure time, both for vigorous physical activity (p = 0.002, p < 0.05), moderate physical activity (p < 0.001, p < 0.05), and for moderate physical activity at work (p = 0.016, p < 0.05). Conclusions: Physical activity during leisure time and moderate physical activity at work showed to be factors associated with a significant decrease in the incidence of fragility hip fractures.

BackgroundYouth in the child welfare system (child welfare-involved [CWI] youth) have high documented rates of mental health symptoms and experience significant disparities in mental health care services access and engagement. Adolescence is a developmental stage that confers increased likelihood of experiencing mental health symptoms and the emergence of disorders that can persist into adulthood. Despite a high documented need for evidence-based mental health services for CWI youth, coordination between child welfare and mental health service systems to increase access to care remains inadequate, and engagement in mental health services is low. Navigator models developed in the health care field to address challenges of service access, fragmentation, and continuity that affect the quality of care provide a promising approach to increase linkage to, and engagement in, mental health services for CWI youth. However, at present, there is no empirically supported mental health navigator model to address the unique and complex mental health needs of CWI youth and their families.ObjectiveUsing a randomized controlled trial, this study aims to develop and test a foster care family navigator (FCFN) model to improve mental health service outcomes for CWI adolescents (aged 12-17 years).MethodsThe navigator model leverages an in-person navigator and use of adjunctive digital health technology to engage with, and improve, care coordination, tracking, and monitoring of mental health service needs for CWI youth and families. In total, 80 caregiver-youth dyads will be randomized to receive either the FCFN intervention or standard of care (clinical case management services): 40 (50%) to FCFN and 40 (50%) to control. Qualitative exit interviews will inform the feasibility and acceptability of the services received during the 6-month period. The primary trial outcomes are mental health treatment initiation and engagement. Other pre- and postservice outcomes, such as proportion screened and time to screening, will also be evaluated. We hypothesize that youth receiving the FCFN intervention will have higher rates of mental health treatment initiation and engagement than youth receiving standard of care.ResultsWe propose enrollment of 80 dyads by March 2024, final data collection by September 2024, and the publication of main findings in March 2025. After final data analysis and writing of the results, the resulting manuscripts will be submitted to journals for dissemination.ConclusionsThis study will be the first to produce empirically driven conclusions and recommendations for implementing a family mental health navigation model for CWI youth with long-standing and unaddressed disparities in behavioral health services access. The study findings have potential to have large-scale trial applicability and be feasible and acceptable for eventual system implementation and adoption.Trial registrationClinicalTrials.gov NCT04506437; https://www.clinicaltrials.gov/study/NCT04506437.International registered report identifier (irrid)DERR1-10.2196/49999.

This paper introduces an alternative approach to irradiation modelling within the context of nuclear fuel cycle codes like ANICCA, the fuel cycle code developed by the Belgian Nuclear Research Centre (SCK CEN). The focus lies on upgrading the irradiation module by substituting the CRAM-based depletion calculations for a more flexible and innovative approach based on Multi-Task Learning (MTL). Utilizing data generated with SERPENT2 Monte Carlo simulations, two MTL neural networks are developed to surrogate irradiation processes of Uranium Oxide (UOX) and Mixed Oxide (MOX) fuels, respectively. MTL enables simultaneous learning of the evolution of the inventories for different observables – i.e., transuranium elements, fission products, minor actinides and fertile materials – offering improved predictive capabilities compared to non-MTL neural networks, as demonstrated in the cross-validation tests.Hyperparameters of the models were found using Bayesian optimization, resulting in superior model performance compared to the old CRAM-based model. Verification against SERPENT2, used as a reference code for comparison, demonstrates the stability and accuracy of the MTL-based models, outperforming the original CRAM method for the majority of predicted isotopes.