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153. Pregnancy and Infants' Outcome: Nutritional and Metabolic Implications.

Author

Berti, C., Cetin, I., Agostoni, C., Desoye, G., Devlieger, R., Emmett, P. M., Ensenauer, R., Hauner, H., Herrera, E., Hoesli, I., Krauss-Etschmann, S., Olsen, S. F., Schaefer-Graf, U., Schiessl, B., Symonds, M. E., and Koletzko, B.

Subjects
NUTRITION in pregnancy, MATERNAL health, FETAL nutrition, BODY mass index, GESTATIONAL age, PREVENTION of pregnancy complications, BIOLOGICAL models, CHILD development, EVALUATION of medical care, MOTHERS, NUTRITIONAL requirements, NUTRITION disorders in infants, NUTRITION policy, PATIENT compliance, PREGNANCY, PREGNANCY complications, WORLD health, WEIGHT gain, FETAL development, RELATIVE medical risk, NUTRITIONAL status, PREVENTION
Abstract

Pregnancy is a complex period of human growth, development, and imprinting. Nutrition and metabolism play a crucial role for the health and well-being of both mother and fetus, as well as for the long-term health of the offspring. Nevertheless, several biological and physiological mechanisms related to nutritive requirements together with their transfer and utilization across the placenta are still poorly understood. In February 2009, the Child Health Foundation invited leading experts of this field to a workshop to critically review and discuss current knowledge, with the aim to highlight priorities for future research. This paper summarizes our main conclusions with regards to maternal preconceptional body mass index, gestational weight gain, placental and fetal requirements in relation to adverse pregnancy and long-term outcomes of the fetus (nutritional programming). We conclude that there is an urgent need to develop further human investigations aimed at better understanding of the basis of biochemical mechanisms and pathophysiological events related to maternal-fetal nutrition and offspring health. An improved knowledge would help to optimize nutritional recommendations for pregnancy. [ABSTRACT FROM PUBLISHER]

Published
2016
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157. Concentrations of dioxins and other organochlorines (PCBs, DDTs, HCHs) in human milk from Seveso, Milan and a Lombardian rural area in Italy: a study performed 25 years after the heavy dioxin exposure in Seveso

Author

Weiss, J, primary, Päpke, O, additional, Bignert, A, additional, Jensen, S, additional, Greyerz, E, additional, Agostoni, C, additional, Besana, R, additional, Riva, E, additional, Giovannini, M, additional, and Zetterström, R, additional

Published
2007
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178. PC92 APPETITE CONTROL IN BREASTFED AND MILK FORMULA FED INFANTS

Author

Gruszfeld, D., primary, Janas, R., additional, Socha, J., additional, Koletzko, B., additional, Broekaert, I., additional, Brasseur, D., additional, Sengier, A., additional, Giovannini, M., additional, Agostoni, C., additional, Monasterolo, R. Closa, additional, and Luque, V., additional

Published
2004
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182. Developmental quotient at 24 months and fatty acid composition of diet in early infancy: a follow up study.

Author

Agostoni C, Trojan S, Bellù R, Riva E, Bruzzese MG, Giovannini M, Agostoni, C, Trojan, S, Bellù, R, Riva, E, Bruzzese, M G, and Giovannini, M

Abstract

Aim: A follow up study of developmental quotient (DQ) at 24 months of toddlers whose diets in early infancy differed in fatty acid composition, and in whom an association between diet and DQ was observed at 4 months.Methods: 81 toddlers were distributed among three groups according to early type of diets standard infant formula (SFo, n = 30); long chain polyunsaturated fatty acid (LC-PUFA) enriched formula (LCPFo, n = 26); human milk (HM, n = 25). DQ at 24 months was assessed by Brunet-Léxine's psychomotor developmental test. A subgroup (n = 20; SFo 8; LCPFo 6; HM 6) was tested for erythrocyte phosphatidyicholine and phosphatidylethanolamine.Results: No DQ differences were found by analysis of variance. Neither DQ nor erythrocyte docosahexaenoic acid at 4 months were predictors of DQ scores at 24 months. Phosphatidylcholine arachidonic and docosahexaenoic acid correlated positively, and phosphatidylcholine linoleic acid and phosphatidylethanolamine eicosapentaenoic acid negatively, with DQ. Multiple regression analysis including these variables explained 52% of inter-individual DQ variance. A strong association was found between the erythrocyte phosphatidylcholine arachidonic/ linoleic acid ratio and DQ (r = 0.75; p = 0.0001).Conclusions: The diet/DQ association found at 4 months was not predictive of DQ scores at 24 months. Irrespective of dietary or genetic factors, there appears to be a strong correlation between the LC-PUFA composition of the red cell membrane and higher neurodevelopmental performance. [ABSTRACT FROM AUTHOR]

Published
1997
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