Search

Your search keyword '"Adem, Abdu"' showing total 673 results
Start Over Author "Adem, Abdu"
673 results on '"Adem, Abdu"'

153. Measurement and Comparison of Organic Compound Concentrations in Plasma, Whole Blood, and Dried Blood Spot Samples.

Author

Batterman, Stuart A., Chernyak, Sergey, Feng-Chiao Su, Stemmer, Paul, and Adem,, Abdu

Subjects
ORGANIC compounds, PLASMA gases, BLOOD
Abstract

The preferred sampling medium for measuring human exposures of persistent organic compounds (POPs) is blood, and relevant sample types include whole blood, plasma, and dried blood spots (DBS). Because information regarding the performance and comparability of measurements across these sample types is limited, it is difficult to compare across studies. This study evaluates the performance of POP measurements in plasma, whole blood and DBS, and presents the distribution coefficients needed to convert concentrations among the three sample types. Blood samples were collected from adult volunteers, along with demographic and smoking information, and analyzed by GC/MS for organochlorine pesticides (OCPs), chlorinated hydrocarbons (CHCs), polychlorinated biphenyls (PCBs), and brominated diphenyl ethers (PBDEs). Regression models were used to evaluate the relationships between the sample types and possible effects of personal covariates. Distribution coefficients also were calculated using physically-based models. Across all compounds, concentrations in plasma were consistently the highest; concentrations in whole blood and DBS samples were comparable. Distribution coefficients for plasma to whole blood concentrations ranged from 1.74 to 2.26 for pesticides/CHCs, averaged 1.69 ± 0.06 for the PCBs, and averaged 1.65 ± 0.03 for the PBDEs. Regression models closely fit most chemicals (R² > 0.80), and whole blood and DBS samples generally showed very good agreement. Distribution coefficients estimated using biologically-based models were near one and did not explain the observed distribution. Among the study population, median concentrations of several pesticides/CHCs and PBDEs exceeded levels reported in the 2007-2008 National Health and Nutrition Examination Survey, while levels of other OCPs and PBDEs were comparable or lower. Race and smoking status appeared to slightly affect plasma/blood concentration ratios for several POPs. The experimentally-determined distribution coefficients can be used to compare POP exposures across studies using different types of blood-based matrices. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

158. Responses to Dehydration in the One-Humped Camel and Effects of Blocking the Renin-Angiotensin System

Author

Ali, Mahmoud Alhaj, primary, Adem, Abdu, additional, Chandranath, Irwin S., additional, Benedict, Sheela, additional, Pathan, Javed Y., additional, Nagelkerke, Nicolas, additional, Nyberg, Fred, additional, Lewis, Lynley K., additional, Yandle, Tim G., additional, Nicholls, Gary M., additional, Frampton, Chris M., additional, and Kazzam, Elsadig, additional

Published
2012
Full Text
View/download PDF

170. List of Contributors

Author

Crider, A. Michael, Adem, Abdu, Abuzenadah, Adel M., Jawad, Ali, Repsold, Benjamin P., Decourt, Boris, Martínez-Rincón, Carmen, Jun, Daniel, Pope, Darrick, Fischer, David F., Klaver, David William, Rodríguez-Martínez, Dolores, Owens, Eric A., Nepovimova, Eugenie, Nasim, Faizul H., Zeidán-Chuliá, Fares, Ahmad, Farhan Jalees, Ansari, Farzana L., Zemek, Filip, Tesco, Giuseppina, Aliev, Gjumrakch, Ahmad, Iqbal, Ortuño-Soriano, Ismael, Petzer, Jacobus P., Joubert, Jacques, Korabecny, Jan, Ahmad, Javed, Moreira, José Cláudio Fonseca, Pacheco-del-Cerro, José L., Frearson, Julie, Kuca, Kamil, Musilek, Kamil, Sandoval, Karin E., Spilovska, Katarina, Witt, Kenneth A., Pacheco-Cuevas, Lara, Prins, Louis H.A., Henary, Maged M., Kontoyianni, Maria, Sabbagh, Marwan, Alcolea-Palafox, Mauricio, Cascio, Michael, Wall, Michael D., Macias, MiMi, Embaby, Mohamed A., Kamal, Mohammad A., Ahmad, Mohammad Zaki, Jabir, Nasimudeen R., Grieg, Nigel H., Sultana, Nighat, Aziz, Omar, Soukup, Ondrej, Sulaiman, Othman, Posada-Moreno, Paloma, Seneci, Pierfausto, Ghalib, Raza Murad, Hashim, Rokiah, Bürli, Roland W., Malan, Sarel F., Mehdi, Sayed Hasan, Tabrez, Shams, Akhter, Sohail, Punganuru, Surendra Reddy, Dost, Tyler L., Rashid, Umer, Revadigar, Vageesh, Murugaiyah, Vikneswaran, Saify, Zafar Saied, and Rahman, Ziyaur

Published
2015
Full Text
View/download PDF

191. Oxime-type acetylcholinesterase reactivators in pregnancy: an overview.

Author

Nurulain, Syed, Kornelia, Tekes, Naqvi, Syed, Sharma, Charu, Ojha, Shreesh, and Adem, Abdu

Subjects
ACETYLCHOLINESTERASE, ORGANOPHOSPHORUS compounds, PREGNANCY complications, NEURAL transmission, POISONING
Abstract

Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. Because of the widespread usage and exposure of organophosphorus compounds (OPCs), its poisoning and fatalities is obvious in pregnant women, embryos and fetuses. OPCs irreversibly inhibit acetylcholinesterase (AChE) at nerve synapses. Furthermore, the role of AChE other than neurotransmission termination has been defined in the literature. The growing evidences show that cholinergic mechanisms are involved during growth and development of other organ systems. In contrary to the fact, the data on the use of oxime-AChER in OPC poisoning in pregnancy are scanty. The present review aimed to comprehend the status of oximes in pregnancy in lieu of the published literature. A thorough literature search was performed in January 2013, using ten popular search engines including Medline/PubMed, Google scholar, etc., using nine standard keywords. The search period was set from 1966 to present. The search did not reveal substantial data. No considerable studies were retrieved which could really demonstrate either the beneficial, harmful or even null effect of oxime-AChER usage in pregnancy. Only eighteen relevant articles were obtained for a period of about 47 years. In the literature, there is no report available to demonstrate the risk of using oxime-AChER in pregnancy for the treatment of OPC poisoning. The study reveals that the use of oxime-AChER in pregnancy is largely un-addressed, inconclusive and based on speculation albeit the incidences of OPC poisoning are quite prevalent. Well-designed studies are warranted for a tangible conclusion. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results