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Turmeric is a commonly known natural spice that contains many phytoconstituents. Among which Curcumin is a polyphenol present in turmeric responsible for many pharmacological actions. Curcumin is still used as a traditional medicine in fields such as Ayurvedic, Siddha, and Unani. Though Curcumin has a large number of activities, it has disadvantages, such as small shelf life due to poor chemical stability, poor absorption results in less bioavailability, less water solubility, rapid metabolism results in quick elimination from the systemic circulation. A Deep eutectic solvent (DES) is a new class of solvents. Hydrophobic DES can be used for dissolving water-insoluble compounds. DES can be prepared when two solid components mixed in a particular proportion are converted into liquid. DES can be used as a solvent for dissolving water-insoluble compounds and to increase the stability. In this work initially, curcumin linearity studies were conducted in different buffers. A buffer showing maximum absorbance was selected from the linearity studies. Then, DES was prepared by combining Camphor:Menthol (1:1) (CM-DES), Camphor:Thymol (1:1) (CT-DES) and, Menthol:Thymol (1:1) (MT-DES). The stability of curcumin in different DES was determined from the stock and working solutions in benchtop condition (room temperature) and, refrigerator condition (5±3°C). Only working solution stability was determined in the in vitro media temperature (37±2°C). From this study, it was concluded that 50 mM Sodium dihydrogen orthophosphate with 0.5% SLS at pH 5.5 showed maximum absorbance value compared with other buffers, so it was selected for further studies. From stability studies, it was found that curcumin in CM-DES was found to be stable in both stock and working solutions compared to the other two CT-DES and MT-DES.

Kikuchi-Fujimoto disease (KFD), also referred to as histiocytic necrotizing lymphadenitis, is an uncommon entity, usually benign, self-limiting disease characterised by fever and regional lymphadenopathy of unexplained aetiology. There is an increase in reported cases of KFD, particularly in Asia. It is important to recognize this condition because it may be confused for systemic lupus erythematosus (SLE), tuberculosis or lymphoma. The knowledge of this condition among clinicians and pathologists can help to avoid misdiagnosis and inappropriate treatment. It must be considered among the differential diagnoses of cervical lymphadenopathy. Here, we present a case of 20-year-old male who came to the hospital with complaints of mild fever, chills, fatigue and cervical lymphadenopathy. After radiological investigations an excisional biopsy of the cervical lymph node was done and the diagnosis of KFD was confirmed. Due to the paucity of cases in literature, reporting this case may help shed light on this rare disease.

Background: Cardiac arrest is the most common cause of death worldwide, and early intervention with high quality BLS improves a victim’s chances of survival. A patient in cardiac arrest is treated by early CPR and early defibrillation and administration of Emergency Drugs. Therefore, Every Health Care Professional student should be Knowledgeable about cardiac arrest and its management to save the precious life of patient. Objective: To assess the Knowledge of Cardiac Arrest and its management among Health Care Professional Students and to educate and create awareness and Knowledge about Cardiac arrest and its management among Heath Care Professional Students Methodology: A cross sectional study conducted in Chennai and Kanchipuram, from July 9th 2022 to September 9th 2022. Permission was obtained from IEC; a well-organized questionnaire was executed with 23 items using the Google Forms. Pre- structured questions were pre-validated by Experts. Google form contains the details such as socio-demographic, knowledge and its management-based questions. The Completed data was collected, entered in excel sheet and the results was analyzed with the proper statistical method. Results: According to the statistical analysis of data received, it results, only 4% (21 participants) of health care professional students have good knowledge about cardiac arrest and its management, only 36% (188 participants) of health care professional students have adequate knowledge about cardiac arrest and its management and 60% (316 participants) of health care professional students have inadequate knowledge about cardiac arrest and its management. Conclusion: This study highly suggests that training programs, simulation-based trainings, seminars and Lecture, etc.… need to be organized to the health care professional students to make them gain knowledge about cardiac arrest and its management to save the precious lives.

Background:Cardiac arrest is the most common cause of death worldwide, and early intervention withhigh quality BLS improves a victims chances of survival. A patient in cardiac arrest is treated by early CPR and early defibrillation and administration of Emergency Drugs. Therefore, Every Health Care Professional student should be Knowledgeable about cardiac arrest and its management to save the precious life of patient. Objective:To assess the Knowledge of Cardiac Arrest and its management among Health Care Professional Students andto educate and create awareness and Knowledge about Cardiac arrest and its management among Heath Care Professional Students Methodology:A cross sectional study conducted in Chennai and Kanchipuram, from July 9th2022 to September 9th2022.Permission was obtained from IEC a well-organized questionnaire was executed with 23 items using the Google Forms. Pre- structured questions were pre-validated by Experts. Google form contains the details such as socio-demographic, knowledge and its management-based questions. The Completed data was collected, entered in excel sheet and the results was analyzed with the proper statistical method. Results:According to the statistical analysis of data received, it results, only 4% (21 participants) of health care professional students have good knowledge about cardiac arrest and its management, only 36% (188 participants) of health care professional students have adequate knowledge about cardiac arrest and its management and 60% (316 participants) of health care professional students have inadequate knowledge about cardiac arrest and its management. Conclusion:This study highly suggests thattraining programs, simulation-based trainings, seminars and Lecture, etc.… need to be organized to the health care professional students to make them gainknowledge about cardiac arrest and its management to save the precious lives.&nbsp

The objectives of current review are (1) to provide a historical overview of artificial intelligence and deep/machine learning (AI & D/ML) or Artificial Neural Network (ANN) (2) to update the financial dealings of pharma companies related to the application of AI & D/ML or ANN in drug discovery and development processes and (3) to showcase the application of AI & D/ML or ANN concept for optimization of analytical method conditions and formula of the dosage form. The optimization of analytical method conditions and formula of dosage form started with the employment of linear model such as design of experiment followed by non-linear model like AI & D/ML or ANN. Such type of linear and non-linear models blending in optimization processes nevertheless helped to suitably identify the influence of critical process parameters or critical material attributes on critical quality attributes. However, much of integration and understandable interpretation between the available data arised from clinical trials and the prevalence/progression of pandemic/endemic infections could potentially be ambitioned through the application of AI & D/ML or ANN.

Ranunculus wallichianus is a medicinally important plant and an endemic species to the Western Ghats of South India. An efficient and reliable indirect regeneration protocol system for R. wallichianus was developed from leaf explants in the present investigation. Leaf explants were cultured on both full-strength and half-strength MS (Murashige & Skoog) medium supplemented with different concentrations (0.5 mg L− 1 to 3.0 mg L− 1) of 2,4-D and NAA. Among the different concentrations tested, the highest percentage of yellowish-green compact nodular callus formation was observed on a half-strength MS medium with 2.0 mg L− 1 of 2, 4-D. Then, the in vitro raised organogenic callus was cultured on a half-strength MS medium containing various concentrations (0.5 mg L− 1 to 3.0 mg L− 1) of BA, KIN, and TDZ with 0.5 mg L− 1 NAA and 10 % CW for in vitro shoot regeneration. The highest percentage of regeneration response (97 %) and a maximum number of shoots formation (11.1 ± 0.13 shoots/culture with 9.2 ± 0.21 cm mean shoot length) were obtained from MS medium containing 2.5 mg L− 1 BA with 0.5 mg L− 1 NAA and 10 % CW. The well elongated in vitro raised shoots were effectively rooted in a half-strength MS medium with 2.5 mg L− 1 IBA + 250 mg L− 1 activated charcoal. The well-rooted plantlets were successfully hardened and acclimatized with a survival rate of 94 %. Clonal fidelity of in vitro raised plantlets was assessed by using DNA-based RAPD and ISSR molecular markers. A total of 56 and 47 monomorphic bands were obtained from RAPD and ISSR markers respectively. This present in vitro propagation protocol system could be effective for the conservation of R. wallichianus with their genetic purity and its further investigations. The present study develops a protocol for mass multiplication of Ranunuculus wallichianus through indirect organogenesis and evaluates the clonal fidelity of regenerants by using RAPD and ISSR markers.

The utilization of either aqueous or conventional/traditional volatile organic compound-based extraction/product development processes in the pharmaceutical industry has become questionable because of the water solubility limitations of active pharmaceutical ingredients (APIs) and stringent regulatory issues concerning the safety aspect of volatile organic compounds (VOCs). The use of neoteric solvents (nonconventional/nontraditional) is being encouraged during API extraction from whole plants or plant tissues and for during pharmaceutical product development. In this review, we provide an overview of the utilization of four neoteric solvents (supercritical fluids, fluorous solvents, ionic liquids, and deep eutectic solvents) in API extraction and pharmaceutical product development processes. Our review highlights solvent-less or solvent-free reactions, which could replace neoteric solvents in drug development in the future.

Nicobari fowl constitute an endemic poultry germplasm of Andaman and Nicobar Islands, India. Genetic diversity, population structure and ancestry of Nicobari fowl were analysed with mitochondrial D-loop sequences. Analysis of complete D-loop sequences (1231-1232 bp) showed 46 polymorphic sites resulting in 26 haplotypes with overall haplotype diversity of 0.895 and nucleotide diversity of 0.0064. Analysis of molecular variance of spatial populations (sampling sites) of Nicobari fowl revealed that the estimated

A novel, economic, simple, precise and time-efficient reverse-phase high performance liquid chromatographic (RPHPLC) method has been established for the simultaneous assay determination of Dolutegravir, Lamivudine and Tenofovir Disoproxil fumarate in tablet formulation. This research paper presents the detailed method development strategy and the outcome of validation challenges. The RPHPLC method was developed using a 150 x 4.6mm, 5µm C18 column, with a gradient mode using 0.1% (v/v) trifluoroacetic acid buffer and methanol, the detection was performed at 260nm. The method was validated for specificity, precision, linearity, accuracy, robustness and can be used in quality control during manufacture and for assessment of the stability samples of Dolutegravir/Lamivudine/Tenofovir Disoproxil fumarate tablets. Total elution time was about 5 min and equilibration time of about 2 min which allows analysis of more than 100 samples per day. The method reported in this study is compatible to mass spectrometry and is thus extremely useful for stability studies.

In this work, we have to introduce a generalized quadratic functional equation and derive its solution. The main objective of this work is to investigate the Hyers-Ulam stability of quadratic functional equation in non-Archimedean n , β -normed spaces.

This work addresses the impact of magnetohydrodynamic Darcy–Forchheimer flow of third-grade nanofluid towards a linearly elastic sheet. Examination has been undertaken in the attendance of velocity slip, Newtonian heating, and non-Fourier heat and mass flux which has not been studied previously. Based on Darcy–Forchheimer model was implemented to illustrate the flow during the porous medium. The entropy minimization of the total system is calculated. Suitable variables are implemented to change the obtained mathematical models into an ODE models. Series solutions are derived by adopting homotopic simulation. After that, the complete investigation of the impact of flow regime on distinct thermofluidic parameters are conferred in the way of graphs and tables. To find the precision of the present solution scheme, a comparison table in limiting conditions is done between the previously available literature and the present results.

Andaman and Nicobar Islands, a part of South-East Asia, is enriched with the presence of native breeds of livestock (cattle, pig, goat) and poultry. There are two native goat breeds, viz., Andaman local goat and Teressa goat in Andaman and Nicobar Islands. However, to date, the origin and genetic makeup of these two breeds have not been detailed. Therefore, the present study describes the genetic makeup of Andaman goats through analysis of mitochondrial D-loop sequence for sequence polymorphism, phylogeographical signaling and population expansion events. The genetic diversity of the Teressa goat was less compared to the Andaman local goat due to its sole presence on Teressa Island. Out of 38 well-defined haplotypes of Andaman goats, the majority of haplotypes belonged to haplogroup A followed by haplogroup B and haplogroup D. The result of mismatch distribution and neutrality tests indicated no population expansion event of haplogroup A and B. Finally, based on poor geographical signaling, we hypothesize that Andaman goats have been imported to these Islands either through multidirectional diffusion or unidirectional diffusion. We justify our hypothesis of multidirectional diffusion on the basis of observation of the haplotype and nucleotide diversity of Andaman goats. Simultaneously, the probability of unidirectional diffusion of goats in these islands from the Indian subcontinent in different spells of domestication events through maritime routes cannot be ignored.

The object of this work is to an innovation of a class k − U ~ S T s ℏ , υ , τ , ι , ς in Y with negative coefficients, further determining coefficient estimates, neighborhoods, partial sums, convexity, and compactness of this specified class.

The aim of this work is to introduce a new mixed type quadratic-additive functional equation, to obtain its general solution and to investigate Ulam stability by using Hyers method in random normed spaces.

The synthesis and characterization of novel antimony(III) dithiocarbamate complexes tris(N-furfuryl- N-propyldithiocarbamato-S,S′)antimony(III) (1) and tris(N-furfuryl-N-butyldithiocarbamato- S,S′)antimony(III) (2) have been characterized by elemental analysis, FT-IR, NMR (1H and 13C) spectra and antimicrobial studies. The characteristic thioureide (νC-N) bands occur at 1462 and 1475 cm-1 for complex 1 and 2, respectively. The theoretical calculations of the complexes have been carried out by density functional theory (DFT). The FMOs, MEP, Mulliken charge distribution and chemical activity parameters of the optimized structure have been calculated at the same level of theory. The MEP structure indicated that the positive and negative potential sites are around hydrogen atoms and electronegative atoms of the studied complexes, respectively. The Agar-well diffusion method were used to study the antimicrobial activity of the complexes against two Gram-positive bacteria (Klebsiella pneumoniae and Staphylococcus aureus), two Gram-negative bacteria (Escherichia coli and Vibrio cholera) and two fungal organisms (Candida albicans and Aspergillus niger).

The availability of fresh water is approximately 1% and the availability of sea water is nearly 99%. The freshwater is depleting rapidly as the demand of it increases year by year. In order to solve this, desalination of sea water is the only solution. Desalination which is in practice in many parts of the world are typically based on the need of large amount of high grade energy. To have a sustainable development, the desalination should be carried out by means of available renewable energy. In this paper a small scale desalination system is designed. In this system, a parabolic dish is used to concentrate the radiation coming from the sun to the focal point and a solar still is placed at the focal point. The pH, hardness, chloride and TDS were determined before and after the conduct of experiment. The evaporation and condensation process inside the still gives water with a lower TDS.

The authors introduce a finite variable quadratic functional equation and derive its solution. Also, authors examine its Hyers-Ulam stability in Random Normed space(RN-space) by means of two different methods.