32,708 results on '"A. P. Sullivan"'
Search Results
152. “Textbook outcome(s)” in colorectal surgery: a systematic review and meta-analysis
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Mac Curtain, Benjamin M., Qian, Wanyang, O’Mahony, Aaron, Deshwal, Avinash, Mac Curtain, Reuben D., Temperley, Hugo C., Sullivan, Niall O., and Ng, Zi Qin
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- 2024
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153. Response Surface Model for Mechanical Properties of Robotically Stitched Composites
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Alaziz, Radwa, Saha, Shuvam, and Sullivan, Rani W.
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- 2024
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154. Measuring the impact of pharmaceutical care bundle delivery on patient outcomes: an observational study
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Canning, Martin Luke, McDougall, Ross, Yerkovich, Stephanie, Barras, Michael, Coombes, Ian, Sullivan, Clair, and Whitfield, Karen
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- 2024
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155. Hypothalamic sex-specific metabolic shift by canagliflozin during aging
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Jayarathne, Hashan S. M., Sullivan, Ryan, Stilgenbauer, Lukas, Debarba, Lucas K., Kuchumov, Artur, Koshko, Lisa, Scofield, Sydney, Liu, Wanqing, Ginsburg, Brett C., Miller, Richard A., and Sadagurski, Marianna
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- 2024
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156. Visualizing three-dimensional effects of synthetic jet flow control
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Machado, Adnan, Xu, Kecheng, and Sullivan, Pierre E.
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- 2024
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157. A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age
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McGee, Kirsty C., Sullivan, Jack, Hazeldine, Jon, Schmunk, Lisa J., Martin-Herranz, Daniel E., Jackson, Thomas, and Lord, Janet M.
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- 2024
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158. Indigenous LGBTIQSB + People’s Experiences of Family Violence in Australia
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Soldatic, Karen, Sullivan, Corrinne T., Briskman, Linda, Leha, John, Trewlynn, William, and Spurway, Kim
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- 2024
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159. Real-time measurements of gas-phase organic acids using SF6− chemical ionization mass spectrometry
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T. Nah, Y. Ji, D. J. Tanner, H. Guo, A. P. Sullivan, N. L. Ng, R. J. Weber, and L. G. Huey
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Environmental engineering ,TA170-171 ,Earthwork. Foundations ,TA715-787 - Abstract
The sources and atmospheric chemistry of gas-phase organic acids are currently poorly understood, due in part to the limited range of measurement techniques available. In this work, we evaluated the use of SF6− as a sensitive and selective chemical ionization reagent ion for real-time measurements of gas-phase organic acids. Field measurements are made using chemical ionization mass spectrometry (CIMS) at a rural site in Yorkville, Georgia, from September to October 2016 to investigate the capability of this measurement technique. Our measurements demonstrate that SF6− can be used to measure a range of organic acids in the atmosphere. One-hour averaged ambient concentrations of organic acids ranged from a few parts per trillion by volume (ppt) to several parts per billion by volume (ppb). All the organic acids displayed similar strong diurnal behaviors, reaching maximum concentrations between 17:00 and 19:00 EDT. The organic acid concentrations are dependent on ambient temperature, with higher organic acid concentrations being measured during warmer periods.
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- 2018
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160. Characterization of aerosol composition, aerosol acidity, and organic acid partitioning at an agriculturally intensive rural southeastern US site
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T. Nah, H. Guo, A. P. Sullivan, Y. Chen, D. J. Tanner, A. Nenes, A. Russell, N. L. Ng, L. G. Huey, and R. J. Weber
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Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The implementation of stringent emission regulations has resulted in the decline of anthropogenic pollutants including sulfur dioxide (SO2), nitrogen oxides (NOx), and carbon monoxide (CO). In contrast, ammonia (NH3) emissions are largely unregulated, with emissions projected to increase in the future. We present real-time aerosol and gas measurements from a field study conducted in an agriculturally intensive region in the southeastern US during the fall of 2016 to investigate how NH3 affects particle acidity and secondary organic aerosol (SOA) formation via the gas–particle partitioning of semi-volatile organic acids. Particle water and pH were determined using the ISORROPIA II thermodynamic model and validated by comparing predicted inorganic HNO3-NO3− and NH3-NH4+ gas–particle partitioning ratios with measured values. Our results showed that despite the high NH3 concentrations (average 8.1±5.2 ppb), PM1 was highly acidic with pH values ranging from 0.9 to 3.8, and an average pH of 2.2±0.6. PM1 pH varied by approximately 1.4 units diurnally. Formic and acetic acids were the most abundant gas-phase organic acids, and oxalate was the most abundant particle-phase water-soluble organic acid anion. Measured particle-phase water-soluble organic acids were on average 6 % of the total non-refractory PM1 organic aerosol mass. The measured molar fraction of oxalic acid in the particle phase (i.e., particle-phase oxalic acid molar concentration divided by the total oxalic acid molar concentration) ranged between 47 % and 90 % for a PM1 pH of 1.2 to 3.4. The measured oxalic acid gas–particle partitioning ratios were in good agreement with their corresponding thermodynamic predictions, calculated based on oxalic acid's physicochemical properties, ambient temperature, particle water, and pH. In contrast, gas–particle partitioning ratios of formic and acetic acids were not well predicted for reasons currently unknown. For this study, higher NH3 concentrations relative to what has been measured in the region in previous studies had minor effects on PM1 organic acids and their influence on the overall organic aerosol and PM1 mass concentrations.
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- 2018
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161. Safety, immunogenicity and efficacy of the self-amplifying mRNA ARCT-154 COVID-19 vaccine: pooled phase 1, 2, 3a and 3b randomized, controlled trials
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Hồ, Nhân Thị, Hughes, Steven G., Ta, Van Thanh, Phan, Lân Trọng, Đỗ, Quyết, Nguyễn, Thượng Vũ, Phạm, Anh Thị Văn, Thị Ngọc Đặng, Mai, Nguyễn, Lượng Viết, Trịnh, Quang Vinh, Phạm, Hùng Ngọc, Chử, Mến Văn, Nguyễn, Toàn Trọng, Lương, Quang Chấn, Tường Lê, Vy Thị, Nguyễn, Thắng Văn, Trần, Lý-Thi-Lê, Thi Van Luu, Anh, Nguyen, Anh Ngoc, Nguyen, Nhung-Thi-Hong, Vu, Hai-Son, Edelman, Jonathan M., Parker, Suezanne, Sullivan, Brian, Sullivan, Sean, Ruan, Qian, Clemente, Brenda, Luk, Brian, Lindert, Kelly, Berdieva, Dina, Murphy, Kat, Sekulovich, Rose, Greener, Benjamin, Smolenov, Igor, Chivukula, Pad, Nguyễn, Vân Thu, and Nguyen, Xuan-Hung
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- 2024
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162. Resonant Multi-Scalar Production in the Generic Complex Singlet Model in the Multi-TeV Region
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Lane, Samuel D., Lewis, Ian M., and Sullivan, Matthew
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High Energy Physics - Phenomenology - Abstract
We develop benchmarks for resonant di-scalar production in the generic complex singlet scalar extension of the Standard Model (SM), which contains two new scalars. These benchmarks maximize di-scalar resonant production: $pp\rightarrow h_2 \rightarrow h_1 h_1/h_1h_3/h_3h_3$, where $h_1$ is the observed SM-like Higgs boson and $h_{2,3}$ are new scalars. The decays $h_2\rightarrow h_1h_3$ and $h_2\rightarrow h_3h_3$ may be the only way to discover $h_3$, leading to a discovery of two new scalars at once. Current LHC and projected future collider (HL-LHC, FCC-ee, ILC500) constraints are used to produce benchmarks at the HL-LHC for $h_2$ masses between 250 GeV and 1 TeV and a future $pp$ collider for $h_2$ masses between 250 GeV and 12 TeV. We update the current LHC bounds on the singlet-Higgs boson mixing angle. As the mass of $h_2$ increases, certain limiting behaviors of the maximum rates are uncovered due to theoretical constraints on the parameters. These limits, which can be derived analytically, are ${\rm BR}(h_2\rightarrow h_1h_1)\rightarrow 0.25$, ${\rm BR}(h_2\rightarrow h_3h_3)\rightarrow 0.5$, and ${\rm BR}(h_2\rightarrow h_1h_3) \rightarrow 0$. It can also be shown that the maximum rates of $pp\rightarrow h_2\rightarrow h_1h_1/h_3h_3$ approach the same value. Hence, all three $h_2\rightarrow h_ih_j$ decays are promising discovery modes for $h_2$ masses below $\mathcal{O}(1\,{\rm TeV})$, while above $\mathcal{O}(1\,{\rm TeV})$ the decays $h_2\rightarrow h_1h_1/h_3h_3$ are more encouraging. Masses for $h_3$ are chosen to produce a large range of signatures including multi-b, multi-vector boson, and multi-$h_1$ production. The behavior of the maximum rates imply that in the multi-TeV region this model may be discovered in the Higgs quartet production mode before Higgs triple production is observed. The maximum di- and four Higgs production rates are similar in the multi-TeV range., Comment: v2: matches version accepted by PRD, typos fixed, references added, discussion expanded, results unchanged, 28 pgs+21 pgs of appendices and references, 9 figures; v1: 27 pages+20 pages of appendices and references, 9 figures
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- 2024
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163. LiteBIRD Science Goals and Forecasts: Primordial Magnetic Fields
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Paoletti, D., Rubino-Martin, J., Shiraishi, M., Molinari, D., Chluba, J., Finelli, F., Baccigalupi, C., Errard, J., Gruppuso, A., Lonappan, A. I., Tartari, A., Allys, E., Anand, A., Aumont, J., Ballardini, M., Banday, A. J., Barreiro, R. B., Bartolo, N., Bersanelli, M., Bortolami, M., Brinckmann, T., Calabrese, E., Campeti, P., Carones, A., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Conenna, G., Coppolecchia, A., Cuttaia, F., D'Alessandro, G., de Bernardis, P., Della Torre, S., Diego-Palazuelos, P., Eriksen, H. K., Fuskeland, U., Galloni, G., Galloway, M., Gerbino, M., Gervasi, M., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., Grupp, F., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Hivon, E., Ichiki, K., Ishino, H., Kohri, K., Komatsu, E., Krachmalnicoff, N., Lamagna, L., Lattanzi, M., Lembo, M., Levrier, F., López-Caniego, M., Luzzi, G., Martínez-González, E., Masi, S., Matarrese, S., Micheli, S., Migliaccio, M., Monelli, M., Montier, L., Morgante, G., Mousset, L., Nagata, R., Namikawa, T., Natoli, P., Novelli, A., Obata, I., Occhiuzzi, A., Odagiri, K., Pagano, L., Paiella, A., Pascual-Cisneros, G., Piacentini, F., Piccirilli, G., Remazeilles, M., Ritacco, A., Ruiz-Granda, M., Sakurai, Y., Scott, D., Stever, S. L., Sullivan, R. M., Takase, Y., Tassis, K., Terenzi, L., Tristram, M., Vacher, L., van Tent, B., Vielva, P., Wehus, I. K., Weymann-Despres, G., Zannoni, M., and Zhou, Y.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present detailed forecasts for the constraints on primordial magnetic fields (PMFs) that will be obtained with the LiteBIRD satellite. The constraints are driven by the effects of PMFs on the CMB anisotropies: the gravitational effects of magnetically-induced perturbations; the effects on the thermal and ionization history of the Universe; the Faraday rotation imprint on the CMB polarization; and the non-Gaussianities induced in polarization anisotropies. LiteBIRD represents a sensitive probe for PMFs and by exploiting all the physical effects, it will be able to improve the current limit coming from Planck. In particular, thanks to its accurate $B$-mode polarization measurement, LiteBIRD will improve the constraints on infrared configurations for the gravitational effect, giving $B_{\rm 1\,Mpc}^{n_{\rm B} =-2.9} < 0.8$ nG at 95% C.L., potentially opening the possibility to detect nanogauss fields with high significance. We also observe a significant improvement in the limits when marginalized over the spectral index, $B_{1\,{\rm Mpc}}^{\rm marg}< 2.2$ nG at 95% C.L. From the thermal history effect, which relies mainly on $E$-mode polarization data, we obtain a significant improvement for all PMF configurations, with the marginalized case, $\sqrt{\langle B^2\rangle}^{\rm marg}<0.50$ nG at 95% C.L. Faraday rotation constraints will take advantage of the wide frequency coverage of LiteBIRD and the high sensitivity in $B$ modes, improving the limits by orders of magnitude with respect to current results, $B_{1\,{\rm Mpc}}^{n_{\rm B} =-2.9} < 3.2$ nG at 95% C.L. Finally, non-Gaussianities of the $B$-mode polarization can probe PMFs at the level of 1 nG, again significantly improving the current bounds from Planck. Altogether our forecasts represent a broad collection of complementary probes, providing conservative limits on PMF characteristics that will be achieved with LiteBIRD., Comment: 51 pages, 24 figures, abstract shortened
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- 2024
164. PureConnect: A Localized Social Media System to Increase Awareness and Connectedness in Environmental Justice Communities
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Hammad, Omar, Rahman, Md Rezwanur, Kanugo, Gopala Krishna Vasanth, Clements, Nicholas, Miller, Shelly, Mishra, Shivakant, and Sullivan, Esther
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Computer Science - Social and Information Networks ,Computer Science - Human-Computer Interaction - Abstract
Frequent disruptions like highway constructions are common now-a-days, often impacting environmental justice communities (communities with low socio-economic status with disproportionately high and adverse human health and environmental effects) that live nearby. Based on our interactions via focus groups with the members of four environmental justice communities impacted by a major highway construction, a common concern is a sense of uncertainty about project activities and loss of social connectedness, leading to increased stress, depression, anxiety and diminished well-being. This paper addresses this concern by developing a localized social media system called PureConnect with a goal to raise the level of awareness about the project and increase social connectedness among the community members. PureConnect has been designed using active engagement with four environmental justice communities affected by a major highway construction. It has been deployed in the real world among the members of the four environmental justice communities, and a detailed analysis of the data collected from this deployment as well as surveys show that PureConnect is potentially useful in improving community members' well-being and the members appreciate the functionalities it provides., Comment: Submitted in COMPSAC 2024
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- 2024
165. Narrow absorption lines from intervening material in supernovae I. Measurements and temporal evolution
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González-Gaitán, Santiago, Gutiérrez, Claudia P., Anderson, Joseph P., Morales-Garoffolo, Antonia, Galbany, Lluis, Goswami, Sabyasashi, Mourao, Ana M., Mattila, Seppo, and Sullivan, Mark
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Narrow absorption features in nearby supernova (SN) spectra are a powerful diagnostic of the slow-moving material in the line of sight: they are extensively used to infer dust extinction from the host galaxies, and they can also serve in the detection of circumstellar material originating from the SN progenitor and present in the vicinity of the explosion. Despite their wide use, very few studies have examined the biases of the methods to characterize narrow lines, and not many statistical analyses exist. This is the first paper of a series in which we present a statistical analysis of narrow lines of SN spectra of various resolutions. We develop a robust automated methodology to measure the equivalent width (EW) and velocity of narrow absorption lines from intervening material in the line of sight of SNe, including Na I D , Ca II H&K, K i and diffuse interstellar bands (DIBs). We carefully study systematic biases in heterogeneous spectra from the literature by simulating different signal-to-noise, spectral resolution, slit size and orientation and present the real capabilities and limitations of using low- and mid-resolution spectra to study these lines. In particular, we find that the measurement of the equivalent width of the narrow lines in low-resolution spectra is highly affected by the evolving broad P-Cygni profiles of the SN ejecta, both for core-collapse and type Ia SNe, inducing a conspicuous apparent evolution. We present thus an easy way to detect and exclude those cases to obtain more robust and reliable measurements. Finally, after considering all possible effects, we analyse the temporal evolution of the narrow features in a large sample of nearby SNe to detect any possible variation in their EWs over time. We find no time evolution of the narrow line features in our large sample for all SN types, Comment: Accepted in A&A
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- 2024
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166. Testbeam analysis of biasing structures for irradiated hybrid pixel detectors
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Rennie, Adam G., Buttar, Craig M., Gao, Yanyan, López, Ricardo González, Maneuski, Dzmitry, Pender, Emily, Qin, Quake, Sullivan, Matthew, Taylor, Jon T., and Wraight, Kenneth
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
Following the Phase-II upgrade during Long Shutdown (LS3), the LHC aims to reach a peak instantaneous luminosity of $7.5\times 10^{34}$cm$^{-2}$s$^{-1}$, which corresponds to an average of around 200 inelastic proton-proton collisions per beam-crossing (every 25 ns). To cope with these conditions, the ATLAS Inner Detector will be replaced by a new all-silicon system -- the Inner Tracker (ITk). The ITk will be operational for more than ten years, during which time ATLAS is expected to record approximately 4000 fb$^{-1}$ of data. The ITk's pixel sub-system is based on hybrid pixel modules with new silicon sensors and readout chips. These studies focus on testbeam campaigns undertaken to study the spatial resolution and efficiencies of hybrid pixel detector modules based on the first large-structure prototype front-end readout chip -- the RD53A -- using planar silicon sensors. These devices have been irradiated to replicate the effect of the high radiation environment present during operation in the ATLAS detector. Results for devices using sensors with different punch-through bias structures and using different readout chips are summarised. Those with sensors incorporating a punch-through bias structure are found to exhibit systematically lower efficiency than those without, as a result of local areas of relative inefficiency around the punch-through dots. Despite this, all devices measured are found to satisfy the requirement of 97% efficiency at $V_\mathrm{bias}=400$ V after being irradiated to end-of-life fluence., Comment: 26 pages, 18 figures, prepared for submission to JINST. There have been some minor language changes for clarity and consistency. A more appropriate diagram for the punchthrough biasing structures discussed has replaced the previous one. Some plots have been enlarged for readability. There was a small bug in Figure 10b, which has been amended. Results and conclusions are unaffected
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- 2024
167. Observation of Seven Astrophysical Tau Neutrino Candidates with IceCube
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IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Fischer, L., Fox, D., Franckowiak, A., Fritz, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Ishihara, A., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlickmann, L., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seikh, M., Seunarine, S., Shah, R., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, F., Yu, S., Zhang, Z., Zhelnin, P., Zilberman, P., and Zimmerman, M.
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Astrophysics - High Energy Astrophysical Phenomena ,High Energy Physics - Experiment - Abstract
We report on a measurement of astrophysical tau neutrinos with 9.7 years of IceCube data. Using convolutional neural networks trained on images derived from simulated events, seven candidate $\nu_\tau$ events were found with visible energies ranging from roughly 20 TeV to 1 PeV and a median expected parent $\nu_\tau$ energy of about 200 TeV. Considering backgrounds from astrophysical and atmospheric neutrinos, and muons from $\pi^\pm/K^\pm$ decays in atmospheric air showers, we obtain a total estimated background of about 0.5 events, dominated by non-$\nu_\tau$ astrophysical neutrinos. Thus, we rule out the absence of astrophysical $\nu_\tau$ at the $5\sigma$ level. The measured astrophysical $\nu_\tau$ flux is consistent with expectations based on previously published IceCube astrophysical neutrino flux measurements and neutrino oscillations., Comment: Accepted for publication in Physical Review Letters. This version includes full author list metadata
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- 2024
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168. Improved modeling of in-ice particle showers for IceCube event reconstruction
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Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Ausborm, L., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Bash, S., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Braun, J., Brinson, B., Brostean-Kaiser, J., Brusa, L., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Caracas, I., Carloni, K., Carpio, J., Chattopadhyay, S., Chau, N., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Corley, R., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Draper, L., Dujmovic, H., Dutta, K., DuVernois, M. A., Ehrhardt, T., Eidenschink, L., Eimer, A., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Genton, E., Gerhardt, L., Ghadimi, A., Girard-Carillo, C., Glaser, C., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Granados, A., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Ha, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Handt, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Häußler, J., Helbing, K., Hellrung, J., Hermannsgabner, J., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hostert, M., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., Ishihara, A., Iwakiri, W., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kamp, N., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katil, A., Katz, U., Kauer, M., Kelley, J. L., Khanal, M., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Liao, J., Lincetto, M., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Magnus, E., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Pernice, T., Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rosted, A., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaile, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seikh, M., Seo, M., Seunarine, S., Myhr, P. Sevle, Shah, R., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Terliuk, A., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Turcotte, R., Twagirayezu, J. P., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Vaidyanathan, A., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Wang, A., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Zilberman, P., and Zimmerman, M.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Data Analysis, Statistics and Probability - Abstract
The IceCube Neutrino Observatory relies on an array of photomultiplier tubes to detect Cherenkov light produced by charged particles in the South Pole ice. IceCube data analyses depend on an in-depth characterization of the glacial ice, and on novel approaches in event reconstruction that utilize fast approximations of photoelectron yields. Here, a more accurate model is derived for event reconstruction that better captures our current knowledge of ice optical properties. When evaluated on a Monte Carlo simulation set, the median angular resolution for in-ice particle showers improves by over a factor of three compared to a reconstruction based on a simplified model of the ice. The most substantial improvement is obtained when including effects of birefringence due to the polycrystalline structure of the ice. When evaluated on data classified as particle showers in the high-energy starting events sample, a significantly improved description of the events is observed., Comment: 28 pages, 18 figures, 1 table, submitted to JINST, updated to account for comments received
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- 2024
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169. AlloyASG: Alloy Predicate Code Representation as a Compact Structurally Balanced Graph
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Wu, Guanxuan and Sullivan, Allison
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Computer Science - Software Engineering ,Computer Science - Programming Languages - Abstract
Writing declarative models has numerous benefits, ranging from automated reasoning and correction of design-level properties before systems are built to automated testing and debugging of their implementations after they are built. Unfortunately, the model itself needs to be correct to gain these benefits. Alloy is a commonly used modeling language that has several existing efforts to repair faulty models automatically. Currently, these efforts are search-based methods that use an Abstract Syntax Tree (AST) representation of the model and do not scale. One issue is that ASTs themselves suffer from exponential growth in their data size due to the limitation that ASTs will often have identical nodes separately listed in the tree. To address this issue, we introduce a novel code representation schema, Complex Structurally Balanced Abstract Semantic Graph (CSBASG), which represents code as a complex-weighted directed graph that lists a semantic element as a node in the graph and ensures its structural balance for almost finitely enumerable code segments. We evaluate the efficiency of our CSBASG representation for Alloy models in terms of it's compactness compared to ASTs, and we explore if a CSBASG can ease the process of comparing two Alloy predicates. Moreover, with this representation in place, we identify several future applications of CSBASG, including Alloy code generation and automated repair., Comment: 12 pages
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- 2024
170. The Dark Energy Survey 5-year photometrically classified type Ia supernovae without host-galaxy redshifts
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Möller, A., Wiseman, P., Smith, M., Lidman, C., Davis, T. M., Kessler, R., Sako, M., Sullivan, M., Galbany, L., Lee, J., Nichol, R. C., Sánchez, B. O., Vincenzi, M., Tucker, B. E., Abbott, T. M. C., Aguena, M., Allam, S., Alves, O., Andrade-Oliveira, F., Bacon, D., Bertin, E., Brooks, D., Rosell, A. Carnero, Castander, F. J., Desai, S., Diehl, H. T., Everett, S., Ferrero, I., Friedel, D., Frieman, J., García-Bellido, J., Gaztanaga, E., Giannini, G., Gruendl, R. A., Gutierrez, G., Hinton, S. R., Hollowood, D. L., Honscheid, K., James, D. J., Kuehn, K., Lahav, O., Lee, S., Marshall, J. L., Mena-Fernández, J., Menanteau, F., Miquel, R., Myles, J., Ogando, R. L. C., Palmese, A., Pieres, A., Malagón, A. A. Plazas, Roodman, A., Sanchez, E., Cid, D. Sanchez, Sevilla-Noarbe, I., Suchyta, E., Swanson, M. E. C., Tarle, G., Tucker, D. L., Walker, A. R., Weaverdyck, N., da Costa, L. N., and Pereira, M. E. S.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Current and future Type Ia Supernova (SN Ia) surveys will need to adopt new approaches to classifying SNe and obtaining their redshifts without spectra if they wish to reach their full potential. We present here a novel approach that uses only photometry to identify SNe Ia in the 5-year Dark Energy Survey (DES) dataset using the SuperNNova classifier. Our approach, which does not rely on any information from the SN host-galaxy, recovers SNe Ia that might otherwise be lost due to a lack of an identifiable host. We select 2,298 high-quality SNe Ia from the DES 5-year dataset an almost complete sample of detected SNe Ia. More than 700 of these have no spectroscopic host redshift and are potentially new SNIa compared to the DES-SN5YR cosmology analysis. To analyse these SNe Ia, we derive their redshifts and properties using only their light-curves with a modified version of the SALT2 light-curve fitter. Compared to other DES SN Ia samples with spectroscopic redshifts, our new sample has in average higher redshift, bluer and broader light-curves, and fainter host-galaxies. Future surveys such as LSST will also face an additional challenge, the scarcity of spectroscopic resources for follow-up. When applying our novel method to DES data, we reduce the need for follow-up by a factor of four and three for host-galaxy and live SN respectively compared to earlier approaches. Our novel method thus leads to better optimisation of spectroscopic resources for follow-up., Comment: Accepted MNRAS
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- 2024
171. Characterization of the Astrophysical Diffuse Neutrino Flux using Starting Track Events in IceCube
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Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Ausborm, L., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Bash, S., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Braun, J., Brinson, B., Brostean-Kaiser, J., Brusa, L., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Caracas, I., Carloni, K., Carpio, J., Chattopadhyay, S., Chau, N., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Corley, R., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Draper, L., Dujmovic, H., Dutta, K., DuVernois, M. A., Ehrhardt, T., Eidenschink, L., Eimer, A., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Genton, E., Gerhardt, L., Ghadimi, A., Girard-Carillo, C., Glaser, C., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Granados, A., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Ha, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Handt, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Häußler, J., Helbing, K., Hellrung, J., Hermannsgabner, J., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hostert, M., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., Ishihara, A., Iwakiri, W., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kamp, N., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katil, A., Katz, U., Kauer, M., Kelley, J. L., Khanal, M., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Liao, J., Lincetto, M., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Magnus, E., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Pernice, T., Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rosted, A., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaile, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seikh, M., Seo, M., Seunarine, S., Myhr, P. Sevle, Shah, R., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Terliuk, A., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Turcotte, R., Twagirayezu, J. P., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Vaidyanathan, A., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Wang, A., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Zilberman, P., and Zimmerman, M.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
A measurement of the diffuse astrophysical neutrino spectrum is presented using IceCube data collected from 2011-2022 (10.3 years). We developed novel detection techniques to search for events with a contained vertex and exiting track induced by muon neutrinos undergoing a charged-current interaction. Searching for these starting track events allows us to not only more effectively reject atmospheric muons but also atmospheric neutrino backgrounds in the southern sky, opening a new window to the sub-100 TeV astrophysical neutrino sky. The event selection is constructed using a dynamic starting track veto and machine learning algorithms. We use this data to measure the astrophysical diffuse flux as a single power law flux (SPL) with a best-fit spectral index of $\gamma = 2.58 ^{+0.10}_{-0.09}$ and per-flavor normalization of $\phi^{\mathrm{Astro}}_{\mathrm{per-flavor}} = 1.68 ^{+0.19}_{-0.22} \times 10^{-18} \times \mathrm{GeV}^{-1} \mathrm{cm}^{-2} \mathrm{s}^{-1} \mathrm{sr}^{-1}$ (at 100 TeV). The sensitive energy range for this dataset is 3 - 550 TeV under the SPL assumption. This data was also used to measure the flux under a broken power law, however we did not find any evidence of a low energy cutoff., Comment: 27 pages, 28 figures
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- 2024
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- View/download PDF
172. Uncertainty Quantification in Atomistic Simulations of Silicon using Interatomic Potentials
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Best, I. R., Sullivan, T. J., and Kermode, J. R.
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Condensed Matter - Materials Science - Abstract
Atomistic simulations often rely on interatomic potentials to access greater time- and length- scales than those accessible to first principles methods such as density functional theory (DFT). However, since a parameterised potential typically cannot reproduce the true potential energy surface of a given system, we should expect a decrease in accuracy and increase in error in quantities of interest calculated from simulations. Quantifying the uncertainty on the outputs of atomistic simulations is thus an important, necessary step so that there is confidence in results and available metrics to explore improvements in said simulations. Here, we address this research question by forming ensembles of Atomic Cluster Expansion (ACE) potentials, and using Conformal Prediction with DFT training data to provide meaningful, calibrated error bars on several quantities of interest for silicon: the bulk modulus, elastic constants, relaxed vacancy formation energy, and the vacancy migration barrier. We evaluate the effects on uncertainty bounds using a range of different potentials and training sets., Comment: 15 pages, 8 figures
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- 2024
- Full Text
- View/download PDF
173. PureNav: A Personalized Navigation Service for Environmental Justice Communities Impacted by Planned Disruptions
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Hammad, Omar, Rahman, Md Rezwanur, Clements, Nicholas, Mishra, Shivakant, Miller, Shelly, and Sullivan, Esther
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Computer Science - Social and Information Networks ,Computer Science - Human-Computer Interaction - Abstract
Planned disruptions such as highway constructions are commonplace nowadays and the communities living near these disruptions generally tend to be environmental justice communities -- low socioeconomic status with disproportionately high and adverse human health and environmental effects. A major concern is that such activities negatively impact people's well-being by disrupting their daily commutes via frequent road closures and increased dust and air pollution. This paper addresses this concern by developing a personalized navigation service called PureNav to mitigate the negative impacts of disruptions in daily commutes on people's well-being. PureNav has been designed using active engagement with four environmental justice communities affected by major highway construction. It has been deployed in the real world among the members of the four communities, and a detailed analysis of the data collected from this deployment as well as surveys show that PureNav is potentially useful in improving people's well-being. The paper describes the design, implementation, and evaluation of PureNav, and offers suggestions for further improving its efficacy., Comment: Accepted for publication in the proceedings of the 2023 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining (ASONAM)
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- 2024
174. Are you Struggling? Dataset and Baselines for Struggle Determination in Assembly Videos
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Feng, Shijia, Wray, Michael, Sullivan, Brian, Jang, Youngkyoon, Ludwig, Casimir, Gilchrist, Iain, and Mayol-Cuevas, Walterio
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Determining when people are struggling from video enables a finer-grained understanding of actions and opens opportunities for building intelligent support visual interfaces. In this paper, we present a new dataset with three assembly activities and corresponding performance baselines for the determination of struggle from video. Three real-world problem-solving activities including assembling plumbing pipes (Pipes-Struggle), pitching camping tents (Tent-Struggle) and solving the Tower of Hanoi puzzle (Tower-Struggle) are introduced. Video segments were scored w.r.t. the level of struggle as perceived by annotators using a forced choice 4-point scale. Each video segment was annotated by a single expert annotator in addition to crowd-sourced annotations. The dataset is the first struggle annotation dataset and contains 5.1 hours of video and 725,100 frames from 73 participants in total. We evaluate three decision-making tasks: struggle classification, struggle level regression, and struggle label distribution learning. We provide baseline results for each of the tasks utilising several mainstream deep neural networks, along with an ablation study and visualisation of results. Our work is motivated toward assistive systems that analyze struggle, support users during manual activities and encourage learning, as well as other video understanding competencies.
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- 2024
175. Correlation Clustering with Vertex Splitting
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Bentert, Matthias, Crane, Alex, Drange, Pål Grønås, Reidl, Felix, and Sullivan, Blair D.
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Computer Science - Data Structures and Algorithms ,Computer Science - Social and Information Networks ,05C85 ,F.2.2 ,I.5.3 - Abstract
We explore Cluster Editing and its generalization Correlation Clustering with a new operation called permissive vertex splitting which addresses finding overlapping clusters in the face of uncertain information. We determine that both problems are NP-hard, yet they exhibit significant differences in parameterized complexity and approximability. For Cluster Editing with Permissive Vertex Splitting, we show a polynomial kernel when parameterized by the solution size and develop a polynomial-time algorithm with approximation factor 7. In the case of Correlation Clustering, we establish para-NP-hardness when parameterized by solution size and demonstrate that computing an $n^{1-\epsilon}$-approximation is NP-hard for any constant $\epsilon > 0$. Additionally, we extend the established link between Correlation Clustering and Multicut to the setting with permissive vertex splitting., Comment: Version 2 includes minor changes incorporating reviewer feedback. Short version appeared at SWAT 2024
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- 2024
176. On the Role of the Wall Curvature in the Development of Flows Reattached over an Airfoil through Unsteady Blowing
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Shirinzad, Ali, Xu, Kecheng, and Sullivan, Pierre Edward
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Physics - Fluid Dynamics - Abstract
An array of twelve circular-orifice synthetic jet actuators (SJAs) was used to provide the unsteady forcing required for flow separation control over a National Advisory Committee for Aeronautics (NACA) 0025 airfoil at a chord-based Reynolds number of 100000 and an angle of attack of 10{\deg}. Two distinct high- and low-forcing frequencies corresponding to the shear layer and wake instabilities were used at an identical blowing strength for flow control. Particle image velocimetry (PIV) was used to measure the velocity fields at the centerline of the airfoil. The results showed the presence of a turbulent shear layer stretching from the edge of the reattached boundary layer to the irrotational flow with an invariant mean spanwise vorticity in the wall-normal direction. It was revealed that the coherent structures for the high-frequency controlled case are advected along the boundary of the rigid-body rotation shear layer and the irrotational flow, whereas for the low-frequency actuation, some structures directly pass through the rigid-body rotation region, disrupting the wall-normal balance of vorticity. Analytical expressions were derived for the variation of the mean spanwise vorticity in the rigid-body rotation region and the curvature-multiplied mean angular momentum in the irrotational flow region based on order-of-magnitude analysis and semi-empirical grounds. The resulting patterns showed an excellent agreement with the measured experimental data.
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- 2024
177. Right or Wrong -- Understanding How Novice Users Write Software Models
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Jovanovic, Ana and Sullivan, Allison
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Computer Science - Software Engineering - Abstract
Writing declarative models has numerous benefits, ranging from automated reasoning and correction of design-level properties before systems are built, to automated testing and debugging of their implementations after they are built. Alloy is a declarative modeling language that is well-suited for verifying system designs. A key strength of Alloy is its scenario-finding toolset, the Analyzer, which allows users to explore all valid scenarios that adhere to the model's constraints up to a user-provided scope. However, even with visualized scenarios, it is difficult to write correct Alloy models. To address this, a growing body of work explores different techniques for debugging Alloy models. In order to develop and evaluate these techniques in an effective manor, this paper presents an empirical study of over 97,000 models written by novice users trying to learn Alloy. We investigate how users write both correct and incorrect models in order to produce a comprehensive benchmark for future use as well as a series of observations to guide debugging and educational efforts for Alloy model development.
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- 2024
178. Every Datapoint Counts: Stellar Flares as a Case Study of Atmosphere Aided Studies of Transients in the LSST Era
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Clarke, Riley W., Davenport, James R. A., Gizis, John, Graham, Melissa L., Li, Xiaolong, Fortino, Willow, Sullivan, Ian, Alsayyad, Yusra, Bosch, James, Knop, Robert A., and Bianco, Federica
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Due to their short timescale, stellar flares are a challenging target for the most modern synoptic sky surveys. The upcoming Vera C. Rubin Legacy Survey of Space and Time (LSST), a project designed to collect more data than any precursor survey, is unlikely to detect flares with more than one data point in its main survey. We developed a methodology to enable LSST studies of stellar flares, with a focus on flare temperature and temperature evolution, which remain poorly constrained compared to flare morphology. By leveraging the sensitivity expected from the Rubin system, Differential Chromatic Refraction can be used to constrain flare temperature from a single-epoch detection, which will enable statistical studies of flare temperatures and constrain models of the physical processes behind flare emission using the unprecedentedly high volume of data produced by Rubin over the 10-year LSST. We model the refraction effect as a function of the atmospheric column density, photometric filter, and temperature of the flare, and show that flare temperatures at or above ~4,000K can be constrained by a single g-band observation at airmass X > 1.2, given the minimum specified requirement on single-visit relative astrometric accuracy of LSST, and that a surprisingly large number of LSST observations is in fact likely be conducted at X > 1.2, in spite of image quality requirements pushing the survey to preferentially low X. Having failed to measure flare DCR in LSST precursor surveys, we make recommendations on survey design and data products that enable these studies in LSST and other future surveys., Comment: 18 pages, 16 figures, 1 table. Submitted to the Astrophysical Journal Supplement Series
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- 2024
179. Physics-based Modeling of Pulse and Relaxation of High-rate Li/CF$_{x}$-SVO batteries in Implantable Medical Devices
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Liang, Qiaohao, Galuppini, Giacomo, Gomadam, Partha M., Tamirisa, Prabhakar A., Lemmerman, Jeffrey A., Mazack, Michael J. M., Sullivan, Melani G., Braatz, Richard D., and Bazant, Martin Z.
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Condensed Matter - Materials Science - Abstract
We present a physics-based model that accurately predicts the performance of Medtronic's implantable medical device battery lithium/carbon monofluoride (CF$_x$) - silver vanadium oxide (SVO) under both low-rate background monitoring and high-rate pulsing currents. The distinct properties of multiple active materials are reflected by parameterizing their thermodynamics, kinetics, and mass transport properties separately. Diffusion limitations of Li$^+$ in SVO are used to explain cell voltage transient behavior during pulse and post-pulse relaxation. We also introduce change in cathode electronic conductivity, Li metal anode surface morphology, and film resistance buildup to capture evolution of cell internal resistance throughout multi-year electrical tests. We share our insights on how the Li$^+$ redistribution process between active materials can restore pulse capability of the hybrid electrode, allow CF$_x$ to indirectly contribute to capacity release during pulsing, and affect the operation protocols and design principles of batteries with other hybrid electrodes. We also discuss additional complexities in porous electrode model parameterization and electrochemical characterization techniques due to parallel reactions and solid diffusion pathways across active materials. We hope our models implemented in the Hybrid Multiphase Porous Electrode Theory (Hybrid-MPET) framework can complement future experimental research and accelerate development of multi-active material electrodes with targeted performance., Comment: For code and sample usage, please visit: https://github.com/HarryQL/Hybrid-MPET/tree/medtronic_pulse
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- 2024
180. Open RL Benchmark: Comprehensive Tracked Experiments for Reinforcement Learning
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Huang, Shengyi, Gallouédec, Quentin, Felten, Florian, Raffin, Antonin, Dossa, Rousslan Fernand Julien, Zhao, Yanxiao, Sullivan, Ryan, Makoviychuk, Viktor, Makoviichuk, Denys, Danesh, Mohamad H., Roumégous, Cyril, Weng, Jiayi, Chen, Chufan, Rahman, Md Masudur, Araújo, João G. M., Quan, Guorui, Tan, Daniel, Klein, Timo, Charakorn, Rujikorn, Towers, Mark, Berthelot, Yann, Mehta, Kinal, Chakraborty, Dipam, KG, Arjun, Charraut, Valentin, Ye, Chang, Liu, Zichen, Alegre, Lucas N., Nikulin, Alexander, Hu, Xiao, Liu, Tianlin, Choi, Jongwook, and Yi, Brent
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Computer Science - Machine Learning - Abstract
In many Reinforcement Learning (RL) papers, learning curves are useful indicators to measure the effectiveness of RL algorithms. However, the complete raw data of the learning curves are rarely available. As a result, it is usually necessary to reproduce the experiments from scratch, which can be time-consuming and error-prone. We present Open RL Benchmark, a set of fully tracked RL experiments, including not only the usual data such as episodic return, but also all algorithm-specific and system metrics. Open RL Benchmark is community-driven: anyone can download, use, and contribute to the data. At the time of writing, more than 25,000 runs have been tracked, for a cumulative duration of more than 8 years. Open RL Benchmark covers a wide range of RL libraries and reference implementations. Special care is taken to ensure that each experiment is precisely reproducible by providing not only the full parameters, but also the versions of the dependencies used to generate it. In addition, Open RL Benchmark comes with a command-line interface (CLI) for easy fetching and generating figures to present the results. In this document, we include two case studies to demonstrate the usefulness of Open RL Benchmark in practice. To the best of our knowledge, Open RL Benchmark is the first RL benchmark of its kind, and the authors hope that it will improve and facilitate the work of researchers in the field., Comment: Under review
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- 2024
181. Invisible Finger: Practical Electromagnetic Interference Attack on Touchscreen-based Electronic Devices
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Shan, Haoqi, Zhang, Boyi, Zhan, Zihao, Sullivan, Dean, Wang, Shuo, and Jin, Yier
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Computer Science - Cryptography and Security - Abstract
Touchscreen-based electronic devices such as smart phones and smart tablets are widely used in our daily life. While the security of electronic devices have been heavily investigated recently, the resilience of touchscreens against various attacks has yet to be thoroughly investigated. In this paper, for the first time, we show that touchscreen-based electronic devices are vulnerable to intentional electromagnetic interference (IEMI) attacks in a systematic way and how to conduct this attack in a practical way. Our contribution lies in not just demonstrating the attack, but also analyzing and quantifying the underlying mechanism allowing the novel IEMI attack on touchscreens in detail. We show how to calculate both the minimum amount of electric field and signal frequency required to induce touchscreen ghost touches. We further analyze our IEMI attack on real touchscreens with different magnitudes, frequencies, duration, and multitouch patterns. The mechanism of controlling the touchscreen-enabled electronic devices with IEMI signals is also elaborated. We design and evaluate an out-of-sight touchscreen locator and touch injection feedback mechanism to assist a practical IEMI attack. Our attack works directly on the touchscreen circuit regardless of the touchscreen scanning mechanism or operating system. Our attack can inject short-tap, long-press, and omni-directional gestures on touchscreens from a distance larger than the average thickness of common tabletops. Compared with the state-of-the-art touchscreen attack, ours can accurately inject different types of touch events without the need for sensing signal synchronization, which makes our attack more robust and practical. In addition, rather than showing a simple proof-of-concept attack, we present and demonstrate the first ready-to-use IEMI based touchscreen attack vector with end-to-end attack scenarios., Comment: This paper has been accepted by 2022 IEEE Symposium on Security and Privacy (SP) and won distinguished paper award
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- 2024
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182. A simple, strong baseline for building damage detection on the xBD dataset
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Gerard, Sebastian, Borne-Pons, Paul, and Sullivan, Josephine
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Computer Science - Computer Vision and Pattern Recognition - Abstract
We construct a strong baseline method for building damage detection by starting with the highly-engineered winning solution of the xView2 competition, and gradually stripping away components. This way, we obtain a much simpler method, while retaining adequate performance. We expect the simplified solution to be more widely and easily applicable. This expectation is based on the reduced complexity, as well as the fact that we choose hyperparameters based on simple heuristics, that transfer to other datasets. We then re-arrange the xView2 dataset splits such that the test locations are not seen during training, contrary to the competition setup. In this setting, we find that both the complex and the simplified model fail to generalize to unseen locations. Analyzing the dataset indicates that this failure to generalize is not only a model-based problem, but that the difficulty might also be influenced by the unequal class distributions between events. Code, including the baseline model, is available under https://github.com/PaulBorneP/Xview2_Strong_Baseline, Comment: 11 pages, 5 figures
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- 2024
183. Artificial Precision Timing Array: bridging the decihertz gravitational-wave sensitivity gap with clock satellites
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Alves, Lucas M. B., Sullivan, Andrew G., Bartos, Imre, Veske, Doğa, Will, Sebastian, Márka, Zsuzsa, and Márka, Szabolcs
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,General Relativity and Quantum Cosmology - Abstract
Gravitational-wave astronomy has developed enormously over the last decade with the first detections across different frequency bands, but has yet to access $0.1-10$ $\mathrm{Hz}$ gravitational waves. Gravitational waves in this band are emitted by some of the most enigmatic sources, including intermediate-mass binary black hole mergers, early inspiralling compact binaries, and possibly cosmic inflation. To tap this exciting band, we propose the construction of a detector based on pulsar timing principles, the Artificial Precision Timing Array (APTA). We envision APTA as a solar system array of artificial "pulsars"$-$precision-clock-carrying satellites that emit pulsing electromagnetic signals towards Earth or other centrum. In this fundamental study, we estimate the clock precision needed for APTA to successfully detect gravitational waves. Our results suggest that a clock relative uncertainty of $10^{-17}$, which is currently attainable, would be sufficient for APTA to surpass LISA's sensitivity in the decihertz band and observe $10^3-10^4$ $\mathrm{M}_\odot$ black hole mergers. Future atomic clock technology realistically expected in the next decade would enable the detection of an increasingly diverse set of astrophysical sources, including stellar-mass compact binaries that merge in the LIGO-Virgo-KAGRA band, extreme-mass-ratio inspirals, and Type Ia supernovae. This work opens up a new area of research into designing and constructing artificial gravitational-wave detectors relying on the successful principles of pulsar timing., Comment: 10 pages, 3 figures
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- 2024
184. Citizen Science for IceCube: Name that Neutrino
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Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Ausborm, L., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Braun, J., Brinson, B., Brostean-Kaiser, J., Brusa, L., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Caracas, I., Carloni, K., Carpio, J., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Corley, R., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Draper, L., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eimer, A., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Genton, E., Gerhardt, L., Ghadimi, A., Girard-Carillo, C., Glaser, C., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Granados, A., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Ha, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Handt, M., Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Häußler, J., Helbing, K., Hellrung, J., Hermannsgabner, J., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hostert, M., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., Ishihara, A., Iwakiri, W., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kamp, N., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katil, A., Katz, U., Kauer, M., Kelley, J. L., Khanal, M., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Magnus, E., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Pernice, T., Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rosted, A., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seikh, M., Seo, M., Seunarine, S., Myhr, P. Sevle, Shah, R., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Terliuk, A., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Vaidyanathan, A., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Warrick, E. H. S., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Zilberman, P., and Zimmerman, M.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Name that Neutrino is a citizen science project where volunteers aid in classification of events for the IceCube Neutrino Observatory, an immense particle detector at the geographic South Pole. From March 2023 to September 2023, volunteers did classifications of videos produced from simulated data of both neutrino signal and background interactions. Name that Neutrino obtained more than 128,000 classifications by over 1,800 registered volunteers that were compared to results obtained by a deep neural network machine-learning algorithm. Possible improvements for both Name that Neutrino and the deep neural network are discussed.
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- 2024
185. Demonstration of Cooperative Transport Interface using open-source 5G OpenRAN and virtualised PON network
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Slyne, Frank, Sullivan, Kevin O, Dzaferagic, Merim, Richardson, Bruce, Wrzeszcz, Marcin, Ryan, Brendan, Power, Niall, Giller, Robin, and Ruffini, Marco
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Computer Science - Networking and Internet Architecture - Abstract
We demonstrate a real-time, converged 5G-PON through the Cooperative Transport Interface, synchronising 5G and PON-DBA upstream schedulers. This innovative approach, implemented using 5G and PON open network implementations, significantly enhances network resource allocation, reducing latency.
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- 2024
186. Migration and Evolution of giant ExoPlanets (MEEP) I: Nine Newly Confirmed Hot Jupiters from the TESS Mission
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Schulte, Jack, Rodriguez, Joseph E., Bieryla, Allyson, Quinn, Samuel N., Collins, Karen A., Yee, Samuel W., Nine, Andrew C., Soares-Furtado, Melinda, Latham, David W., Eastman, Jason D., Barkaoui, Khalid, Ciardi, David R., Dragomir, Diana, Everett, Mark E., Giacalone, Steven, Mireles, Ismael, Murgas, Felipe, Narita, Norio, Shporer, Avi, Strakhov, Ivan A., Striegel, Stephanie, Vaňko, Martin, Vowell, Noah, Wang, Gavin, Ziegler, Carl, Bellaver, Michael, Benni, Paul, Bergeron, Serge, Boffin, Henri M. J., Briceño, César, Clark, Catherine A., Collins, Kevin I., de Leon, Jerome P., Dressing, Courtney D., Evans, Phil, Esparza-Borges, Emma, Fedewa, Jeremy, Fukui, Akihiko, Gan, Tianjun, Gerasimov, Ivan S., Hartman, Joel D., Gill, Holden, Gillon, Michaël, Horne, Keith, Horta, Ferran Grau, Howell, Steve B., Isogai, Keisuke, Jehin, Emmanuël, Jenkins, Jon M., Karjalainen, Raine, Kielkopf, John F., Lester, Kathryn V., Littlefield, Colin, Lund, Michael B., Mann, Andrew W., McCormack, Mason, Michaels, Edward J., Painter, Shane, Palle, Enric, Parviainen, Hannu, Peterson, David-Michael, Pozuelos, Francisco J., Raup, Zachary, Reed, Phillip, Relles, Howard M., Ricker, George R., Savel, Arjun B., Schwarz, Richard P., Seager, Sara, Sefako, Ramotholo, Srdoc, Gregor, Stockdale, Chris, Sullivan, Hannah, Timmermans, Mathilde, and Winn, Joshua N.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Hot Jupiters were many of the first exoplanets discovered in the 1990s, but in the decades since their discovery, the mysteries surrounding their origins remain. Here, we present nine new hot Jupiters (TOI-1855 b, TOI-2107 b, TOI-2368 b, TOI-3321 b, TOI-3894 b, TOI-3919 b, TOI-4153 b, TOI-5232 b, and TOI-5301 b) discovered by NASA's TESS mission and confirmed using ground-based imaging and spectroscopy. These discoveries are the first in a series of papers named the Migration and Evolution of giant ExoPlanets (MEEP) survey and are part of an ongoing effort to build a complete sample of hot Jupiters orbiting FGK stars, with a limiting Gaia $G$-band magnitude of 12.5. This effort aims to use homogeneous detection and analysis techniques to generate a set of precisely measured stellar and planetary properties that is ripe for statistical analysis. The nine planets presented in this work occupy a range of masses (0.55 Jupiter masses (M$_{\rm{J}}$) $<$ M$_{\rm{P}}$ $<$ 3.88 M$_{\rm{J}}$) and sizes (0.967 Jupiter radii (R$_{\rm{J}}$) $<$ R$_{\rm{P}}$ $<$ 1.438 R$_{\rm{J}}$) and orbit stars that range in temperature from 5360 K $<$ Teff $<$ 6860 K with Gaia $G$-band magnitudes ranging from 11.1 to 12.7. Two of the planets in our sample have detectable orbital eccentricity: TOI-3919 b ($e = 0.259^{+0.033}_{-0.036}$) and TOI-5301 b ($e = 0.33^{+0.11}_{-0.10}$). These eccentric planets join a growing sample of eccentric hot Jupiters that are consistent with high-eccentricity tidal migration, one of the three most prominent theories explaining hot Jupiter formation and evolution., Comment: 35 pages, 7 tables, and 14 figures. Submitted to AAS Journals on 2023 Dec 28
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- 2024
187. From low resource information extraction to identifying influential nodes in knowledge graphs
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Cai, Erica, Simek, Olga, Miller, Benjamin A., Sullivan-Pao, Danielle, Young, Evan, and Smith, Christopher L.
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Computer Science - Social and Information Networks - Abstract
We propose a pipeline for identifying important entities from intelligence reports that constructs a knowledge graph, where nodes correspond to entities of fine-grained types (e.g. traffickers) extracted from the text and edges correspond to extracted relations between entities (e.g. cartel membership). The important entities in intelligence reports then map to central nodes in the knowledge graph. We introduce a novel method that extracts fine-grained entities in a few-shot setting (few labeled examples), given limited resources available to label the frequently changing entity types that intelligence analysts are interested in. It outperforms other state-of-the-art methods. Next, we identify challenges facing previous evaluations of zero-shot (no labeled examples) methods for extracting relations, affecting the step of populating edges. Finally, we explore the utility of the pipeline: given the goal of identifying important entities, we evaluate the impact of relation extraction errors on the identification of central nodes in several real and synthetic networks. The impact of these errors varies significantly by graph topology, suggesting that confidence in measurements based on automatically extracted relations should depend on observed network features., Comment: 14 pages, 6 figures, to appear at CompleNet 2024
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- 2024
188. An Integrated Framework for Team Formation and Winner Prediction in the FIRST Robotics Competition: Model, Algorithm, and Analysis
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Galbiati, Federico, Gran, Ranier X., Jacques, Brendan D., Mulhern, Sullivan J., and Ngan, Chun-Kit
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Robotics - Abstract
This research work aims to develop an analytical approach for optimizing team formation and predicting team performance in a competitive environment based on data on the competitors' skills prior to the team formation. There are several approaches in scientific literature to optimize and predict a team's performance. However, most studies employ fine-grained skill statistics of the individual members or constraints such as teams with a set group of members. Currently, no research tackles the highly constrained domain of the FIRST Robotics Competition. This research effort aims to fill this gap by providing an analytical method for optimizing and predicting team performance in a competitive environment while allowing these constraints and only using metrics on previous team performance, not on each individual member's performance. We apply our method to the drafting process of the FIRST Robotics competition, a domain in which the skills change year-over-year, team members change throughout the season, each match only has a superficial set of statistics, and alliance formation is key to competitive success. First, we develop a method that could extrapolate individual members' performance based on overall team performance. An alliance optimization algorithm is developed to optimize team formation and a deep neural network model is trained to predict the winning team, both using highly post-processed real-world data. Our method is able to successfully extract individual members' metrics from overall team statistics, form competitive teams, and predict the winning team with 84.08% accuracy.
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- 2024
189. The Dark Energy Survey Supernova Program: Cosmological Analysis and Systematic Uncertainties
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Vincenzi, M., Brout, D., Armstrong, P., Popovic, B., Taylor, G., Acevedo, M., Camilleri, R., Chen, R., Davis, T. M., Hinton, S. R., Kelsey, L., Kessler, R., Lee, J., Lidman, C., Möller, A., Qu, H., Sako, M., Sanchez, B., Scolnic, D., Smith, M., Sullivan, M., Wiseman, P., Asorey, J., Bassett, B. A., Carollo, D., Carr, A., Foley, R. J., Frohmaier, C., Galbany, L., Glazebrook, K., Graur, O., Kovacs, E., Kuehn, K., Malik, U., Nichol, R. C., Rose, B., Tucker, B. E., Toy, M., Tucker, D. L., Yuan, F., Abbott, T. M. C., Aguena, M., Alves, O., Andrade-Oliveira, F., Annis, J., Bacon, D., Bechtol, K., Bernstein, G. M., Brooks, D., Burke, D. L., Rosell, A. Carnero, Carretero, J., Castander, F. J., Conselice, C., da Costa, L. N., Pereira, M. E. S., Desai, S., Diehl, H. T., Doel, P., Ferrero, I., Flaugher, B., Friedel, D., Frieman, J., García-Bellido, J., Gatti, M., Giannini, G., Gruen, D., Gruendl, R. A., Hollowood, D. L., Honscheid, K., Huterer, D., James, D. J., Kuropatkin, N., Lahav, O., Lee, S., Lin, H., Marshall, J. L., Mena-Fernández, J., Menanteau, F., Miquel, R., Palmese, A., Pieres, A., Malagón, A. A. Plazas, Porredon, A., Romer, A. K., Roodman, A., Sanchez, E., Cid, D. Sanchez, Schubnell, M., Sevilla-Noarbe, I., Suchyta, E., Swanson, M. E. C., Tarle, G., To, C., Walker, A. R., and Weaverdyck, N.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the full Hubble diagram of photometrically-classified Type Ia supernovae (SNe Ia) from the Dark Energy Survey supernova program (DES-SN). DES-SN discovered more than 20,000 SN candidates and obtained spectroscopic redshifts of 7,000 host galaxies. Based on the light-curve quality, we select 1635 photometrically-identified SNe Ia with spectroscopic redshift 0.10$< z <$1.13, which is the largest sample of supernovae from any single survey and increases the number of known $z>0.5$ supernovae by a factor of five. In a companion paper, we present cosmological results of the DES-SN sample combined with 194 spectroscopically-classified SNe Ia at low redshift as an anchor for cosmological fits. Here we present extensive modeling of this combined sample and validate the entire analysis pipeline used to derive distances. We show that the statistical and systematic uncertainties on cosmological parameters are $\sigma_{\Omega_M,{\rm stat+sys}}^{\Lambda{\rm CDM}}=$0.017 in a flat $\Lambda$CDM model, and $(\sigma_{\Omega_M},\sigma_w)_{\rm stat+sys}^{w{\rm CDM}}=$(0.082, 0.152) in a flat $w$CDM model. Combining the DES SN data with the highly complementary CMB measurements by Planck Collaboration (2020) reduces uncertainties on cosmological parameters by a factor of 4. In all cases, statistical uncertainties dominate over systematics. We show that uncertainties due to photometric classification make up less than 10% of the total systematic uncertainty budget. This result sets the stage for the next generation of SN cosmology surveys such as the Vera C. Rubin Observatory's Legacy Survey of Space and Time., Comment: 39 pages, 19 figures; Submitted to ApJ; companion paper Dark Energy Collaboration et al. on consecutive arxiv number 2401.02929
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- 2024
190. The Dark Energy Survey: Cosmology Results With ~1500 New High-redshift Type Ia Supernovae Using The Full 5-year Dataset
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DES Collaboration, Abbott, T. M. C., Acevedo, M., Aguena, M., Alarcon, A., Allam, S., Alves, O., Amon, A., Andrade-Oliveira, F., Annis, J., Armstrong, P., Asorey, J., Avila, S., Bacon, D., Bassett, B. A., Bechtol, K., Bernardinelli, P. H., Bernstein, G. M., Bertin, E., Blazek, J., Bocquet, S., Brooks, D., Brout, D., Buckley-Geer, E., Burke, D. L., Camacho, H., Camilleri, R., Campos, A., Rosell, A. Carnero, Carollo, D., Carr, A., Carretero, J., Castander, F. J., Cawthon, R., Chang, C., Chen, R., Choi, A., Conselice, C., Costanzi, M., da Costa, L. N., Crocce, M., Davis, T. M., DePoy, D. L., Desai, S., Diehl, H. T., Dixon, M., Dodelson, S., Doel, P., Doux, C., Drlica-Wagner, A., Elvin-Poole, J., Everett, S., Ferrero, I., Ferté, A., Flaugher, B., Foley, R. J., Fosalba, P., Friedel, D., Frieman, J., Frohmaier, C., Galbany, L., García-Bellido, J., Gatti, M., Gaztanaga, E., Giannini, G., Glazebrook, K., Graur, O., Gruen, D., Gruendl, R. A., Gutierrez, G., Hartley, W. G., Herner, K., Hinton, S. R., Hollowood, D. L., Honscheid, K., Huterer, D., Jain, B., James, D. J., Jeffrey, N., Kasai, E., Kelsey, L., Kent, S., Kessler, R., Kim, A. G., Kirshner, R. P., Kovacs, E., Kuehn, K., Lahav, O., Lee, J., Lee, S., Lewis, G. F., Li, T. S., Lidman, C., Lin, H., Malik, U., Marshall, J. L., Martini, P., Mena-Fernández, J., Menanteau, F., Miquel, R., Mohr, J. J., Mould, J., Muir, J., Möller, A., Neilsen, E., Nichol, R. C., Nugent, P., Ogando, R. L. C., Palmese, A., Pan, Y. -C., Paterno, M., Percival, W. J., Pereira, M. E. S., Pieres, A., Malagón, A. A. Plazas, Popovic, B., Porredon, A., Prat, J., Qu, H., Raveri, M., Rodríguez-Monroy, M., Romer, A. K., Roodman, A., Rose, B., Sako, M., Sanchez, E., Cid, D. Sanchez, Schubnell, M., Scolnic, D., Sevilla-Noarbe, I., Shah, P., Smith, J. Allyn., Smith, M., Soares-Santos, M., Suchyta, E., Sullivan, M., Suntzeff, N., Swanson, M. E. C., Sánchez, B. O., Tarle, G., Taylor, G., Thomas, D., To, C., Toy, M., Troxel, M. A., Tucker, B. E., Tucker, D. L., Uddin, S. A., Vincenzi, M., Walker, A. R., Weaverdyck, N., Wechsler, R. H., Weller, J., Wester, W., Wiseman, P., Yamamoto, M., Yuan, F., Zhang, B., and Zhang, Y.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present cosmological constraints from the sample of Type Ia supernovae (SN Ia) discovered during the full five years of the Dark Energy Survey (DES) Supernova Program. In contrast to most previous cosmological samples, in which SN are classified based on their spectra, we classify the DES SNe using a machine learning algorithm applied to their light curves in four photometric bands. Spectroscopic redshifts are acquired from a dedicated follow-up survey of the host galaxies. After accounting for the likelihood of each SN being a SN Ia, we find 1635 DES SNe in the redshift range $0.10
0.5$ SNe compared to the previous leading compilation of Pantheon+, and results in the tightest cosmological constraints achieved by any SN data set to date. To derive cosmological constraints we combine the DES supernova data with a high-quality external low-redshift sample consisting of 194 SNe Ia spanning $0.025 - Published
- 2024
191. Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study
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Stinson, Elizabeth A, Sullivan, Ryan M, Navarro, Gabriella Y, Wallace, Alexander L, Larson, Christine L, and Lisdahl, Krista M
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Biological Psychology ,Psychology ,Neurosciences ,Mental Health ,Behavioral and Social Science ,Pediatric ,Prevention ,Women's Health ,Clinical Research ,Neurological ,Mental health ,Adverse childhood experiences ,Adolescence ,Family environment ,Functional magnetic resonance imaging ,Inhibitory control ,Clinical Sciences ,Cognitive Sciences ,Biological psychology ,Clinical and health psychology - Abstract
Adolescence is characterized by dynamic neurodevelopment, which poses opportunities for risk and resilience. Adverse childhood experiences (ACEs) confer additional risk to the developing brain, where ACEs have been associated with alterations in functional magnetic resonance imaging (fMRI) BOLD signaling in brain regions underlying inhibitory control. Socioenvironmental factors like the family environment may amplify or buffer against the neurodevelopmental risks associated with ACEs. Using baseline to Year 2 follow-up data from the Adolescent Brain Cognitive Development (ABCD) Study, the current study examined how ACEs relate to fMRI BOLD signaling during successful inhibition on the Stop Signal Task in regions associated with inhibitory control and examined whether family conflict levels moderated that relationship. Results showed that greater ACEs were associated with reduced BOLD response in the right opercular region of the inferior frontal gyrus and bilaterally in the pre-supplementary motor area, which are key regions underlying inhibitory control. Further, greater BOLD response was correlated with less impulsivity behaviorally, suggesting reduced activation may not be behaviorally adaptive at this age. No significant two or three-way interactions with family conflict levels or time were found. Findings highlight the continued utility of examining the relationship between ACEs and neurodevelopmental outcomes and the importance of intervention/prevention of ACES.
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- 2024
192. Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors.
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Wang, Fengrong, Holmes, Michael, Hong, Hea, Thaprawat, Pariyamon, Kannan, Geetha, Huynh, My-Hang, Schultz, Tracey, Licon, M, Lourido, Sebastian, Dong, Wenzhao, Brito Querido, Jailson, Sullivan, William, OLeary, Seán, and Carruthers, Vern
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Toxoplasma ,Animals ,Protozoan Proteins ,Toxoplasmosis ,Mice ,Mutation ,Ribosomes ,Protein Biosynthesis ,Female ,RNA ,Messenger ,Cell Differentiation ,Humans - Abstract
The parasite Toxoplasma gondii persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that mediate T. gondii differentiation remain poorly understood. Through a mutagenesis screen, we identified translation initiation factor eIF1.2 as a critical factor for T. gondii differentiation. A F97L mutation in eIF1.2 or the genetic ablation of eIF1.2 (∆eif1.2) markedly impeded bradyzoite cyst formation in vitro and in vivo. We demonstrated, at single-molecule level, that the eIF1.2 F97L mutation impacts the scanning process of the ribosome preinitiation complex on a model mRNA. RNA sequencing and ribosome profiling experiments unveiled that ∆eif1.2 parasites are defective in upregulating bradyzoite induction factors BFD1 and BFD2 during stress-induced differentiation. Forced expression of BFD1 or BFD2 significantly restored differentiation in ∆eif1.2 parasites. Together, our findings suggest that eIF1.2 functions by regulating the translation of key differentiation factors necessary to establish chronic toxoplasmosis.
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- 2024
193. Relative Vaccine Effectiveness of Cell- vs Egg-Based Quadrivalent Influenza Vaccine Against Test-Confirmed Influenza Over 3 Seasons Between 2017 and 2020 in the United States.
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Stein, Alicia, Mills, Carrie, McGovern, Ian, McDermott, Kimberly, Dean, Alex, Bogdanov, Alina, Haag, Mendel, and Sullivan, Sheena
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cell-based quadrivalent influenza vaccine ,egg adaptation ,influenza ,influenza virus mismatch ,relative vaccine effectiveness - Abstract
BACKGROUND: Influenza vaccine viruses grown in eggs may acquire egg-adaptive mutations that may reduce antigenic similarity between vaccine and circulating influenza viruses and decrease vaccine effectiveness. We compared cell- and egg-based quadrivalent influenza vaccines (QIVc and QIVe, respectively) for preventing test-confirmed influenza over 3 US influenza seasons (2017-2020). METHODS: Using a retrospective test-negative design, we estimated the relative vaccine effectiveness (rVE) of QIVc vs QIVe among individuals aged 4 to 64 years who had an acute respiratory or febrile illness and were tested for influenza in routine outpatient care. Exposure, outcome, and covariate data were obtained from electronic health records linked to pharmacy and medical claims. Season-specific rVE was estimated by comparing the odds of testing positive for influenza among QIVc vs QIVe recipients. Models were adjusted for age, sex, geographic region, influenza test date, and additional unbalanced covariates. A doubly robust approach was used combining inverse probability of treatment weights with multivariable regression. RESULTS: The study included 31 824, 33 388, and 34 398 patients in the 2017-2018, 2018-2019, and 2019-2020 seasons, respectively; ∼10% received QIVc and ∼90% received QIVe. QIVc demonstrated superior effectiveness vs QIVe in prevention of test-confirmed influenza: rVEs were 14.8% (95% CI, 7.0%-22.0%) in 2017-2018, 12.5% (95% CI, 4.7%-19.6%) in 2018-2019, and 10.0% (95% CI, 2.7%-16.7%) in 2019-2020. CONCLUSIONS: This study demonstrated consistently superior effectiveness of QIVc vs QIVe in preventing test-confirmed influenza over 3 seasons characterized by different circulating viruses and degrees of egg adaptation.
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- 2024
194. A Description of the Imaging Innovations for Placental Assessment in Response to Environmental Pollution Study.
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Janzen, Carla, Lei, Margarida, Lee, Brian, Vangala, Sitaram, DelRosario, Irish, Meng, Qi, Ritz, Beate, Liu, Jonathan, Jerrett, Michael, Chanlaw, Teresa, Choi, Sarah, Aliabadi, Arya, Fortes, Precious, Sullivan, Peggy, Murphy, Aisling, Vecchio, Giorgia, Thamotharan, Shanthie, Sung, Kyung, and Devaskar, Sherin
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Humans ,Female ,Pregnancy ,Magnetic Resonance Imaging ,Adult ,Placenta ,Prospective Studies ,Pregnancy Outcome ,Pregnancy Trimester ,First ,Placenta Diseases ,Infant ,Newborn ,Abruptio Placentae ,Fetal Growth Retardation ,Infant ,Small for Gestational Age ,Ischemia - Abstract
OBJECTIVE: The aim of Placental Assessment in Response to Environmental Pollution Study (PARENTs) was to determine whether imaging of the placenta by novel multiparametric magnetic resonance imaging (MRI) techniques in early pregnancy could help predict adverse pregnancy outcomes (APOs) due to ischemic placental disease (IPD). Additionally, we sought to determine maternal characteristics and environmental risk factors that contribute to IPD and secondary APOs. STUDY DESIGN: Potential patients in their first trimester of pregnancy, who agreed to MRI of the placenta and measures of assessment of environmental pollution, were recruited into PARENTs, a prospective population-based cohort study. Participants were seen at three study visits during pregnancy and again at their delivery from 2015 to 2019. We collected data from interviews, chart abstractions, and imaging. Maternal biospecimens (serum, plasma, and urine) at antepartum study visits and delivery specimens (placenta, cord, and maternal blood) were collected, processed, and stored. The primary outcome was a composite of IPD, which included any of the following: placental abruption, hypertensive disease of pregnancy, fetal growth restriction, or a newborn of small for gestational age. RESULTS: In this pilot cohort, of the 190 patients who completed pregnancy to viable delivery, 50 (26%) developed IPD. Among demographic characteristics, having a history of prior IPD in multiparous women was associated with the development of IPD. In the multiple novel perfusion measurements taken of the in vivo placenta using MRI, decreased high placental blood flow (mL/100 g/min) in early pregnancy (between 14 and 16 weeks) was found to be significantly associated with the later development of IPD. CONCLUSION: Successful recruitment of the PARENTs prospective cohort demonstrated the feasibility and acceptability of the use of MRI in human pregnancy to study the placenta in vivo and at the same time collect environmental exposure data. Analysis is ongoing and we hope these methods will assist researchers in the design of prospective imaging studies of pregnancy. KEY POINTS: · MRI was acceptable and feasible for the study of the human placenta in vivo.. · Functional imaging of the placenta by MRI showed a significant decrease in high placental blood flow.. · Measures of environmental exposures are further being analyzed to predict IPD..
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- 2024
195. Shifting groundwater fluxes in bedrock fractures: Evidence from stream water radon and water isotopes
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Johnson, Keira, Christensen, John N, Gardner, W Payton, Sprenger, Matthias, Li, Li, Williams, Kenneth H, Carroll, Rosemary WH, Thiros, Nicholas, Brown, Wendy, Beutler, Curtis, Newman, Alexander, and Sullivan, Pamela L
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Hydrology ,Earth Sciences ,Geology ,Groundwater surface water interactions ,Tracer hydrology ,Groundwater modeling ,Groundwater discharge ,Montane catchment ,Environmental Engineering - Abstract
Geologic features (e.g., fractures and alluvial fans) can play an important role in the locations and volumes of groundwater discharge and degree of groundwater-surface water (GW-SW) interactions. However, the role of these features in controlling GW-SW dynamics and streamflow generation processes are not well constrained. GW-SW interactions and streamflow generation processes are further complicated by variability in precipitation inputs from summer and fall monsoon rains, as well as declines in snowpack and changing melt dynamics driven by warming temperatures. Using high spatial and temporal resolution radon and water stable isotope sampling and a 1D groundwater flux model, we evaluated how groundwater contributions and GW-SW interactions varied along a stream reach impacted by fractures (fractured-zone) and downstream of the fractured hillslope (non-fractured zone) in Coal Creek, a Colorado River headwater stream affected by summer monsoons. During early summer, groundwater contributions from the fractured zone were high, but declined throughout the summer. Groundwater contributions from the non-fractured zone were constant throughout the summer and became proportionally more important later in the summer. We hypothesize that groundwater in the non-fractured zone is dominantly sourced from a high-storage alluvial fan at the base of a tributary that is connected to Coal Creek throughout the summer and provides consistent groundwater influx. Water isotope data revealed that Coal Creek responds quickly to incoming precipitation early in the summer, and summer precipitation becomes more important for streamflow generation later in the summer. We quantified the change in catchment dynamic storage and found it negatively related to stream water isotope values, and positively related to modeled groundwater discharge and the ratio of fractured zone to non-fractured zone groundwater. We interpret these relationships as declining hydrologic connectivity throughout the summer leading to late summer streamflow supported predominantly by shallow flow paths, with variable response to drying from geologic features based on their storage. As groundwater becomes more important for sustaining summer flows, quantifying local geologic controls on groundwater inputs and their response to variable moisture conditions may become critical for accurate predictions of streamflow.
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- 2024
196. A systematic review of contaminants in donor human milk.
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Thayagabalu, Sionika, Cacho, Nicole, Sullivan, Sandra, Smulian, John, Louis-Jacques, Adetola, Bourgeois, Marie, Chen, Henian, Weerasuriya, Wasana, and Lemas, Dominick
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breast milk ,contaminants ,donor milk ,Humans ,Milk ,Human ,Milk Banks ,Infant ,Newborn ,Food Contamination ,Bacteria ,Environmental Pollutants ,Infant ,Premature ,Female - Abstract
Donor human milk (DHM) from a milk bank is the recommended feeding method for preterm infants when the mothers own milk (MOM) is not available. Despite this recommendation, information on the possible contamination of donor human milk and its impact on infant health outcomes is poorly characterised. The aim of this systematic review is to assess contaminants present in DHM samples that preterm and critically ill infants consume. The data sources used include PubMed, EMBASE, CINAHL and Web of Science. A search of the data sources targeting DHM and its potential contaminants yielded 426 publications. Two reviewers (S. T. and D. L.) conducted title/abstract screening through Covidence software, and predetermined inclusion/exclusion criteria yielded 26 manuscripts. Contaminant types (bacterial, chemical, fungal, viral) and study details (e.g., type of bacteria identified, study setting) were extracted from each included study during full-text review. Primary contaminants in donor human milk included bacterial species and environmental pollutants. We found that bacterial contaminants were identified in 100% of the papers in which bacterial contamination was sought (16 papers) and 61.5% of the full data set (26 papers), with the most frequently identified genera being Staphylococcus (e.g., Staphylococcus aureus and coagulase-negative Staphylococcus) and Bacillus (e.g., Bacillus cereus). Chemical pollutants were discovered in 100% of the papers in which chemical contamination was sought (eight papers) and 30.8% of the full data set (26 papers). The most frequently identified chemical pollutants included perfluoroalkyl substances (six papers), toxic metal (one paper) and caffeine (one paper). Viral and fungal contamination were identified in one paper each. Our results highlight the importance of establishing standardisation in assessing DHM contamination and future studies are needed to clarify the impact of DHM contaminants on health outcomes.
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- 2024
197. Interfacial Assembly of Bacterial Microcompartment Shell Proteins in Aqueous Multiphase Systems
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Abeysinghe, AA Dharani T, Young, Eric J, Rowland, Andrew T, Dunshee, Lucas C, Urandur, Sandeep, Sullivan, Millicent O, Kerfeld, Cheryl A, and Keating, Christine D
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Biochemistry and Cell Biology ,Biological Sciences ,Bioengineering ,Dextrans ,Bacterial Proteins ,bioreactor ,bottom-up synthetic biology ,compartmentalization ,protocell ,self-assembly ,synthetic cell ,bottom‐up synthetic biology ,self‐assembly ,Nanoscience & Nanotechnology - Abstract
Compartments are a fundamental feature of life, based variously on lipid membranes, protein shells, or biopolymer phase separation. Here, this combines self-assembling bacterial microcompartment (BMC) shell proteins and liquid-liquid phase separation (LLPS) to develop new forms of compartmentalization. It is found that BMC shell proteins assemble at the liquid-liquid interfaces between either 1) the dextran-rich droplets and PEG-rich continuous phase of a poly(ethyleneglycol)(PEG)/dextran aqueous two-phase system, or 2) the polypeptide-rich coacervate droplets and continuous dilute phase of a polylysine/polyaspartate complex coacervate system. Interfacial protein assemblies in the coacervate system are sensitive to the ratio of cationic to anionic polypeptides, consistent with electrostatically-driven assembly. In both systems, interfacial protein assembly competes with aggregation, with protein concentration and polycation availability impacting coating. These two LLPS systems are then combined to form a three-phase system wherein coacervate droplets are contained within dextran-rich phase droplets. Interfacial localization of BMC hexameric shell proteins is tunable in a three-phase system by changing the polyelectrolyte charge ratio. The tens-of-micron scale BMC shell protein-coated droplets introduced here can accommodate bioactive cargo such as enzymes or RNA and represent a new synthetic cell strategy for organizing biomimetic functionality.
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- 2024
198. Estimates of Seasonal Influenza Burden That Could Be Averted by Improved Influenza Vaccines in the Australian Population Aged Under 65 Years, 2015-2019.
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Stein, Alicia, Pendrey, Catherine, Muscatello, David, Van Buynder, Paul, Fielding, James, Menche, Jason, and Sullivan, Sheena
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burden of disease ,influenza ,influenza vaccines ,vaccine effectiveness ,Humans ,Aged ,Influenza Vaccines ,Influenza ,Human ,Seasons ,Australia ,Vaccination - Abstract
BACKGROUND: The interpretation of relative vaccine effectiveness (rVE) of improved influenza vaccines is complex. Estimation of burden averted is useful to contextualise their potential impact across different seasons. For the population aged under 65 years in Australia, this study estimated the additional morbidity and mortality that could be averted using improved influenza vaccines. METHODS: We used observed, season-specific (2015-2019) influenza notification and influenza-coded hospitalisation frequencies and published modelled estimates of influenza-associated hospitalisations and deaths that occurred under the prevailing influenza vaccination coverage scenario. After back-calculating to the estimated burden in the population without vaccination, we applied published standard influenza vaccine effectiveness and coverage estimates to calculate the burden potentially averted by standard and improved influenza vaccines. A plausible range of rVE values were used, assuming 50% coverage. RESULTS: The percentage point difference in absolute vaccine effectiveness (VE) of an improved vaccine compared to a standard vaccine is directly proportional to its rVE and inversely proportional to the effectiveness of the standard vaccine. The incremental burden averted by an improved vaccine is a function of both its difference in absolute VE and the severity of the influenza season. Assuming an rVE of 15% with 50% coverage, the improved vaccine was estimated to additionally avert 1517 to 12,641 influenza notifications, 287 to 1311 influenza-coded hospitalisations and 9 to 33 modelled all-cause influenza deaths per year compared to the standard vaccine. CONCLUSIONS: Improved vaccines can have substantial clinical and population impact, particularly when the effectiveness of standard vaccines is low, and burden is high.
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- 2024
199. Computer Vision Analysis of Caregiver-Child Interactions in Children with Neurodevelopmental Disorders: A Preliminary Report
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Dmitry Yu. Isaev, Maura Sabatos-DeVito, J. Matias Di Martino, Kimberly Carpenter, Rachel Aiello, Scott Compton, Naomi Davis, Lauren Franz, Connor Sullivan, Geraldine Dawson, and Guillermo Sapiro
- Abstract
We report preliminary results of computer vision analysis of caregiver-child interactions during free play with children diagnosed with autism (N = 29, 41-91 months), attention-deficit/hyperactivity disorder (ADHD, N = 22, 48-100 months), or combined autism + ADHD (N = 20, 56-98 months), and neurotypical children (NT, N = 7, 55-95 months). We conducted micro-analytic analysis of 'reaching to a toy,' as a proxy for initiating or responding to a toy play bout. Dyadic analysis revealed two clusters of interaction patterns, which differed in frequency of 'reaching to a toy' and caregivers' contingent responding to the child's reach for a toy by also reaching for a toy. Children in dyads with higher caregiver responsiveness had less developed language, communication, and socialization skills. Clusters were not associated with diagnostic groups. These results hold promise for automated methods of characterizing caregiver responsiveness in dyadic interactions for assessment and outcome monitoring in clinical trials.
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- 2024
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- View/download PDF
200. Middle School Staff's Perspectives on the Impact of the Olweus Bullying Prevention Program on Interpersonal Relationships
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Melissa Washington-Nortey, Terri N. Sullivan, Rihana Ahm, Jelani Crosby, Albert Farrell, Kevin Sutherland, and Stephanie Hitti
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The current study used thematic analysis to examine school staff perspectives on the impact of the Olweus Bullying Prevention Program (OBPP) on school climate in terms of the quality of student-student and student-teacher relationships in two low-income, urban middle schools in the United States. Data were collected using focus groups and interviews. Participants included teachers (n = 26), administrators (n = 8), and Bullying Prevention Coordination Committee members (BPCCs; n = 8). Results indicated that providing explicit instruction about bullying, nurturing student-teacher trust by effectively addressing student concerns, and providing consistent opportunities for informal, collaborative engagement facilitated positive school-based interpersonal relationships and behavioral change. Implications for policy and intervention development are discussed.
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- 2024
- Full Text
- View/download PDF
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