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151. Reply

Author

Rondeau, Virginie, Filleul, Laurent, and Cantagrel, Anne

Published
2005

153. Prevalence of comorbidities and evaluation of their screening in spondyloarthritis: results of the international cross-sectional ASAS-COMOSPA study

Author

Moltó, Anna, Etcheto, Adrien, van der Heijde, Désirée, Landewé, Robert, van den Bosch, Filip, Bautista Molano, Wilson, Burgos-Vargas, Ruben, Cheung, Peter P, Collantes-Estevez, Eduardo, Deodhar, Atul, El-Zorkany, Bassel, Erdes, Shandor, Gu, Jieruo, Hajjaj-Hassouni, Najia, Kiltz, Uta, Kim, Tae-Hwan, Kishimoto, Mitsumasa, Luo, Shue-Fen, Machado, Pedro M, Maksymowych, Walter P, Maldonado-Cocco, José, Marzo-Ortega, Helena, Montecucco, Carlo-Maurizio, Ozgoçmen, Salih, van Gaalen, Floris, Dougados, Maxime, Allali, Fadoua, González, Raquel Almodovar, Blanco-Morales, Elena Alonso, Alvarellos, Alejandro, Espinar, Maria Aparicio, Atagunduz, Pamir, Bakker, Pauline, Barreira, Juan C., Benbrahim, Leila, Benchekroun, Bahia, Berman, Alberto, Braun, Juergen, Cantagrel, Alain, Caporali, Roberto, Carvalho, Pedro, Casado, Gustavo, Wei, James Cheng-Chung, Colombres, Francisco, Mendieta, Eugenio del Miguel, Diaz-Garcia, Juan D., de Medicina, Escuela Superior, De Bandt, Michel, Duarte, Vanesa, Carballido, Cristina Fernandez, Espartero, Mari Cruz Fernandez, Fernandez-Prada, Manuel, Flipo, Rene-Marc, Ugalde, Pilar Font, Gaudin, Philippe, Goupille, Philippe, Cánovas, Dolors Grados, Masmitjá, Jordi Gratacós, Grosso, Vittorio, Ichikawa, Naomi, Inoue, Hisashi, Kaneko, Yuko, Kawasaki, Taku, Kobayashi, Shigeto, Lahiri, Manjari, Maldonado-Ficco, Hernán, Martínez, Alejandro, Matsui, Kazuo, Esteban, Ramón Mazzuchelli, Micelli, Corinne, Min, Chisun, Morita, Mitsuhiro, Mendoza, Juan Mulero, Pons, Jose Raul Noguera, Okada, Masato, Ortiz, Alberto, Packham, Jon, Pendón, Gisela, Pereira, Dora, da Silva, José A Pereira, Pimentel-Santos, Fernando, Rkain, Hanan, Rillo, Oscar, Lozano, Carlos Rodriguez, Ruyssen-Witrand, Adeline, Salas, Adrián, Salinas-Ramos, Carlos, Santosa, Amelia, Saraux, Alain, Sengupta, Raj, Siebert, Stefan, Soubrier, Martin, Spiegel, Caroline, Stolwijk, Carmen, Tada, Kurisu, Takizawa, Naoho, Taniguchi, Yoshinori, Taniguchi, Atsuo, Chou, Chung Tei, Teoh, Lay-Keng, Tomita, Tetsuya, Tsai, Wen-Chan, Tsuji, Shigeyoshi, Tsyplenkova, Olga, van Tubergen, Astrid, Vakil-Gilani, Kiana, Valle-Oñate, Rafael, Varkas, Gaelle, Villaverde, Virginia, Yap, Ai, and Montejo, Pedro Zarco

Published
2016
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154. Predictive risk factors of serious infections in patients with rheumatoid arthritis treated with abatacept in common practice: results from the Orencia and Rheumatoid Arthritis (ORA) registry

Author

Salmon, J H, Gottenberg, J E, Ravaud, P, Cantagrel, A, Combe, B, Flipo, R M, Schaeverbeke, T, Houvenagel, E, Gaudin, P, Loeuille, D, Rist, S, Dougados, M, Sibilia, J, Le Loët, X, Meyer, O, Solau-Gervais, E, Marcelli, C, Bardin, T, Pane, I, Baron, G, Perrodeau, E, and Mariette, X

Published
2016
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159. Estudo comparativo de quatro critérios de classificação para artrite psoriásica Comparative study of four classification criteria for psoriatic arthritis

Author

Cláudia Diniz Lopes Marques, Alain Cantagrel, Fernando Cavalcanti, and Ângela Luzia Branco Pinto Duarte

Subjects
artrite psoriásica, critérios de classificação, espondiloartropatias, psoriatic ar thritis, classification criteria, spondyloarthropathies, Diseases of the musculoskeletal system, RC925-935
Abstract

OBJETIVO: comparar o desempenho de quatro grupos de critérios propostos para definir artrite psoriásica (AP) em pacientes portadores de artropatia inflamatória: Moll e Wright, Bennet, Vasey e Espinoza e Fournié. MÉTODOS: foram analisados dados clínicos e laboratoriais de 195 pacientes divididos em dois grupos: 65 portadores de artrite psoriásica (grupo AP) e 130 portadores de artrite reumatóide (grupo AR). Os casos foram representados pelo grupo AP. Após definição dos falsos positivos, verdadeiros negativos, verdadeiros positivos e falsos negativos foram calculadas a sensibilidade e a especificidade de cada critério. RESULTADOS: os critérios de Fournié foram os que apresentaram melhor desempenho, com sensibilidade de 93,84% e especificidade de 96,22%. Os de Bennet foram os que demonstraram sensibilidade mais baixa (26,15%), por outro lado, obtiveram especificidade de 100%. CONCLUSÃO: os critérios de Fournié parecem ser os mais efetivos em identificar as diversas formas da AP, inclusive nos casos da AP sem lesão cutânea ou nas formas entesopáticas difusas, permitindo que se faça diagnóstico mais precocemente e evitando as possíveis complicações que podem levar à incapacidade e deformidades permanentes.OBJECTIVE: to compare the sensitivity and specificity of the four classification criteria of psoriatic arthritis (PA) in patients with inflammatory arthropathy: the Moll's and Wright's criteria, Bennet criteria, Vasey and Espinoza's criteria and Fournié's criteria. METHODS: we analysed 195 patients distributed in two groups: 65 patients with psoriatic arthritis (PA group) and 130 patients with rheumatoid arthritis (RA group). After defining the true positives, true negatives, false positives and false negatives, we calculated the sensitivity and specificity of each criteria. RESULTS: the Fournié's criteria were those with better performance, showing a sensitivity of 93.84% and specificity of 96.22%. The Bennet's criteria had a lower sensitivity (26.15%), but on the other hand, the high specificity (100%). CONCLUSION: the Fournié's criteria appears to be the most efficient to identify the various PA's forms, including the cases of PA without cutaneous psoriasis or in the group with diffuse enthesopathies, allowing an early diagnostic and avoiding the possible complications that can lead to permanent incapacity and deformity.

Published
2006
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161. Use of glucocorticoids in rheumatoid arthritis – Pratical modalities of glucocorticoid therapy: Recommendations for clinical practice based on data from the literature and expert opinion

Author

Dernis, Emmanuelle, Ruyssen-Witrand, Adeline, Mouterde, Gaël, Maillefert, Jean-Francis, Tebib, Jacques, Cantagrel, Alain, Claudepierre, Pascal, Fautrel, Bruno, Gaudin, Philippe, Pham, Thao, Schaeverbeke, Thierry, Wendling, Daniel, Saraux, Alain, and Loët, Xavier Le

Published
2010
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162. Biallelic mutations in neurofascin cause neurodevelopmental impairment and peripheral demyelination

Author

Efthymiou, S., Salpietro, V., Malintan, N., Poncelet, M., Kriouile, Y., Fortuna, S., Zorzi, R. de, Payne, K., Henderson, L.B., Cortese, A., Maddirevula, S., Alhashmi, N., Wiethoff, S., Ryten, M., Botia, J.A., Provitera, V., Schuelke, M., Vandrovcova, J., Groppa, S., Karashova, B.M., Nachbauer, W., Boesch, S., Arning, L., Timmann, D., Cormand, B., Perez-Duenas, B., Goraya, J.S., Sultan, T., Mine, J., Avdjieva, D., Kathom, H., Tincheva, R., Banu, S., Pineda-Marfa, M., Veggiotti, P., Ferrari, M.D., Maagdenberg, A.M.J.M. van den, Verrotti, A., Marseglia, G., Savasta, S., Garcia-Silva, M., Ruiz, A.M., Garavaglia, B., Borgione, E., Portaro, S., Sanchez, B.M., Boles, R., Papacostas, S., Vikelis, M., Rothman, J., Kullmann, D., Papanicolaou, E.Z., Dardiotis, E., Maqbool, S., Ibrahim, S., Kirmani, S., Rana, N.N., Atawneh, O., Lim, S.Y., Shaikh, F., Koutsis, G., Breza, M., Mangano, S., Scuderi, C., Morello, G., Stojkovic, T., Zollo, M., Heimer, G., Dauvilliers, Y.A., Minetti, C., Al-Khawaja, I., Al-Mutairi, F., Hamed, S., Pipis, M., Bettencourt, C., Rinaldi, S., Walsh, L., Torti, E., Iodice, V., Najafi, M., Karimiani, E.G., Maroofian, R., Siquier-Pernet, K., Boddaert, N., Lonlay, P. de, Cantagrel, V., Aguennouz, M., Khorassani, M. el, Schmidts, M., Alkuraya, F.S., Edvardson, S., Nolano, M., Devaux, J., Houlden, H., SYNAPS Study Grp, Efthymiou, S., Salpietro, V., Malintan, N., Poncelet, M., Kriouile, Y., Fortuna, S., De Zorzi, R., Payne, K., Henderson, L. B., Cortese, A., Maddirevula, S., Alhashmi, N., Wiethoff, S., Ryten, M., Botia, J. A., Provitera, V., Schuelke, M., Vandrovcova, J., Walsh, L., Torti, E., Iodice, V., Najafi, M., Karimiani, E. G., Maroofian, R., Siquier-Pernet, K., Boddaert, N., De Lonlay, P., Cantagrel, V., Aguennouz, M., El Khorassani, M., Schmidts, M., Alkuraya, F. S., Edvardson, S., Nolano, M., Devaux, J., Houlden, H., Groppa, S., Karashova, B. M., Nachbauer, W., Boesch, S., Arning, L., Timmann, D., Cormand, B., Perez-Duenas, B., Goraya, J. S., Sultan, T., Mine, J., Avdjieva, D., Kathom, H., Tincheva, R., Banu, S., Pineda-Marfa, M., Veggiotti, P., Ferrari, M. D., Van Den Maagdenberg, A. M. J. M., Verrotti, A., Marseglia, G., Savasta, S., Garcia-Silva, M., Ruiz, A. M., Garavaglia, B., Borgione, E., Portaro, S., Sanchez, B. M., Boles, R., Papacostas, S., Vikelis, M., Rothman, J., Kullmann, D., Papanicolaou, E. Z., Dardiotis, E., Maqbool, S., Ibrahim, S., Kirmani, S., Rana, N. N., Atawneh, O., Lim, S. -Y., Shaikh, F., Koutsis, G., Breza, M., Mangano, S., Scuderi, C., Morello, G., Stojkovic, T., Zollo, M., Heimer, G., Dauvilliers, Y. A., Minetti, C., Al-Khawaja, I., Al-Mutairi, F., Hamed, S., Pipis, M., Bettencourt, C., Rinaldi, S., Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Laboratory of Molecular Biophysics, Department of Biochemistry, Department of Biochemistry, Hertie Institute for Clinical Brain Research and Center for Neurology, University of Tübingen, Department of Medical and Molecular Genetics, King‘s College London, Department of Human Genetics, Ruhr University Bochum (RUB), Universitat de Barcelona (UB), Fondazione, Leiden University Medical Center (LUMC), Department of Physiology and Cellular Biophysics [New York, NY, USA], Columbia University College of Physicians and Surgeons, Department of Microbiology, Università degli studi di Catania [Catania], Institut de Myologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ceinge, centro di Ingegneria Genetica e Biotecnologie Avanzate, Unité des troubles du sommeil, Centre de référence national sur les maladies rares (narcolepsie, hypersomnie idiopathique, syndrome de Kleine-Levin)-Hôpital Gui-de-Chauliac, Muscular and Neurodegenerative Disease Unit, University of Genoa (UNIGE), Department of Molecular Neuroscience, University College of London [London] (UCL)-Institute of Neurology, Indiana University, Indiana University [Bloomington], Indiana University System-Indiana University System, Molecular and Clinical Sciences Institute - St George’s [London, UK] (Genetics Research Centre), University of London [London], Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neuroimagerie en psychiatrie (U1000), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service métabolisme, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-CHU Necker - Enfants Malades [AP-HP], Department of Genetics and Metabolic Diseases and the Monique and Jacques Roboh Department of Genetic Research, Hadassah Hebrew University Medical Center [Jerusalem], Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Efthymiou S., Salpietro V., Malintan N., Poncelet M., Kriouile Y., Fortuna S., De Zorzi R., Payne K., Henderson L.B., Cortese A., Maddirevula S., Alhashmi N., Wiethoff S., Ryten M., Botia J.A., Provitera V., Schuelke M., Vandrovcova J., Walsh L., Torti E., Iodice V., Najafi M., Karimiani E.G., Maroofian R., Siquier-Pernet K., Boddaert N., De Lonlay P., Cantagrel V., Aguennouz M., El Khorassani M., Schmidts M., Alkuraya F.S., Edvardson S., Nolano M., Devaux J., Houlden H., Groppa S., Karashova B.M., Nachbauer W., Boesch S., Arning L., Timmann D., Cormand B., Perez-Duenas B., Goraya J.S., Sultan T., Mine J., Avdjieva D., Kathom H., Tincheva R., Banu S., Pineda-Marfa M., Veggiotti P., Ferrari M.D., Van Den Maagdenberg A.M.J.M., Verrotti A., Marseglia G., Savasta S., Garcia-Silva M., Ruiz A.M., Garavaglia B., Borgione E., Portaro S., Sanchez B.M., Boles R., Papacostas S., Vikelis M., Rothman J., Kullmann D., Papanicolaou E.Z., Dardiotis E., Maqbool S., Ibrahim S., Kirmani S., Rana N.N., Atawneh O., Lim S.-Y., Shaikh F., Koutsis G., Breza M., Mangano S., Scuderi C., Morello G., Stojkovic T., Zollo M., Heimer G., Dauvilliers Y.A., Minetti C., Al-Khawaja I., Al-Mutairi F., Hamed S., Pipis M., Bettencourt C., Rinaldi S., Efthymiou, Stephanie, Salpietro, Vincenzo, Malintan, Nancy, Poncelet, Mallory, Kriouile, Yamna, Fortuna, Sara, De Zorzi, Rita, Payne, Katelyn, Henderson, Lindsay B, Cortese, Andrea, Maddirevula, Sateesh, Alhashmi, Nadia, Wiethoff, Sarah, Ryten, Mina, Botia, Juan A, Provitera, Vincenzo, Schuelke, Marku, Vandrovcova, Jana, Walsh, Laurence, Torti, Erin, Iodice, Valeria, Najafi, Maryam, Karimiani, Ehsan Ghayoor, Maroofian, Reza, Siquier-Pernet, Karine, Boddaert, Nathalie, De Lonlay, Pascale, Cantagrel, Vincent, Aguennouz, Mhammed, El Khorassani, Mohamed, Schmidts, Miriam, Alkuraya, Fowzan S, Edvardson, Simon, Nolano, Maria, Devaux, Jérôme, Houlden, Henry, Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-CHU Necker - Enfants Malades [AP-HP], Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Association française contre les myopathies (AFM-Téléthon)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Pierre et Marie Curie - Paris 6 (UPMC), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
Male, [SDV]Life Sciences [q-bio], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Nerve Fibers, Myelinated, Gene Frequency, Neurodevelopmental Disorder, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Nerve Growth Factor, Protein Isoforms, Child, ComputingMilieux_MISCELLANEOUS, Myelin Sheath, neurofascin, neurodevelopment, peripheral demyelination, Allele, Demyelinating Disease, Genomics, neurodevelopment, neurofascin, peripheral demyelination, Settore MED/39 - Neuropsichiatria Infantile, Pedigree, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, Child, Preschool, Peripheral Nerve, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, Neuroglia, Human, Adult, Adolescent, Nervous System Malformations, Guillain-Barre Syndrome, Axon, Nervous System Malformation, Ranvier's Nodes, Humans, Nerve Growth Factors, Peripheral Nerves, Alleles, Autoantibodies, Infant, Protein Isoform, Original Articles, Axons, nervous system, Neurodevelopmental Disorders, Cell Adhesion Molecule, Mutation, Cell Adhesion Molecules, Demyelinating Diseases
Abstract

See Karakaya and Wirth (doi:10.1093/brain/awz273) for a scientific commentary on this article. Neurofascin (NFASC) isoforms are immunoglobulin cell adhesion molecules involved in node of Ranvier assembly. Efthymiou et al. identify biallelic NFASC variants in ten unrelated patients with a neurodevelopmental disorder characterized by variable degrees of central and peripheral involvement. Abnormal expression of Nfasc155 is accompanied by severe loss of myelinated fibres., Axon pathfinding and synapse formation are essential processes for nervous system development and function. The assembly of myelinated fibres and nodes of Ranvier is mediated by a number of cell adhesion molecules of the immunoglobulin superfamily including neurofascin, encoded by the NFASC gene, and its alternative isoforms Nfasc186 and Nfasc140 (located in the axonal membrane at the node of Ranvier) and Nfasc155 (a glial component of the paranodal axoglial junction). We identified 10 individuals from six unrelated families, exhibiting a neurodevelopmental disorder characterized with a spectrum of central (intellectual disability, developmental delay, motor impairment, speech difficulties) and peripheral (early onset demyelinating neuropathy) neurological involvement, who were found by exome or genome sequencing to carry one frameshift and four different homozygous non-synonymous variants in NFASC. Expression studies using immunostaining-based techniques identified absent expression of the Nfasc155 isoform as a consequence of the frameshift variant and a significant reduction of expression was also observed in association with two non-synonymous variants affecting the fibronectin type III domain. Cell aggregation studies revealed a severely impaired Nfasc155-CNTN1/CASPR1 complex interaction as a result of the identified variants. Immunofluorescence staining of myelinated fibres from two affected individuals showed a severe loss of myelinated fibres and abnormalities in the paranodal junction morphology. Our results establish that recessive variants affecting the Nfasc155 isoform can affect the formation of paranodal axoglial junctions at the nodes of Ranvier. The genetic disease caused by biallelic NFASC variants includes neurodevelopmental impairment and a spectrum of central and peripheral demyelination as part of its core clinical phenotype. Our findings support possible overlapping molecular mechanisms of paranodal damage at peripheral nerves in both the immune-mediated and the genetic disease, but the observation of prominent central neurological involvement in NFASC biallelic variant carriers highlights the importance of this gene in human brain development and function.

Published
2019
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165. Terminal 6q deletions cause brain malformations, a phenotype mimicking heterozygous DLL1 pathogenic variants: A multicenter retrospective case series

Author

Lesieur‐Sebellin, Marion, primary, Till, Marianne, additional, Khau Van Kien, Philippe, additional, Herve, Bérénice, additional, Bourgon, Nicolas, additional, Dupont, Céline, additional, Tabet, Anne‐Claude, additional, Barrois, Mathilde, additional, Coussement, Aurélie, additional, Loeuillet, Laurence, additional, Mousty, Eve, additional, Ea, Vuthy, additional, Assal, Amal, additional, Mary, Laura, additional, Jaillard, Sylvie, additional, Beneteau, Claire, additional, Le Vaillant, Claudine, additional, Coutton, Charles, additional, Devillard, Françoise, additional, Goumy, Carole, additional, Delabaere, Amélie, additional, Redon, Sylvia, additional, Laurent, Yves, additional, Lamouroux, Audrey, additional, Massardier, Jérôme, additional, Turleau, Catherine, additional, Sanlaville, Damien, additional, Cantagrel, Vincent, additional, Sonigo, Pascale, additional, Vialard, François, additional, Salomon, Laurent J., additional, and Malan, Valérie, additional

Published
2021
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167. Emm : un nouveau système de groupe sanguin associé à des troubles neurodéveloppementaux

Author

Duval, Romain, primary, Nicolas, Gael, additional, Willemetz, Alexandra, additional, Murakami, Yoshiko, additional, Mikdar, Mahmoud, additional, Vrignaud, Cedric, additional, Megahed, Hisham, additional, Cartron, Jean-Pierre, additional, Masson, Cecile, additional, Wehbi, Samer, additional, Koehl, Bérengere, additional, Hully, Marie, additional, Siquier, Karine, additional, Chemlay, Nicole, additional, Rotig, Agnes, additional, Lyonnet, Stanislas, additional, Colin, Yves, additional, Barcia, Giulia, additional, Cantagrel, Vincent, additional, Le Van Kim, Caroline, additional, Hermine, Olivier, additional, Kinoshita, Taroh, additional, Peyrard, Thierry, additional, and Azouzi, Slim, additional

Published
2021
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168. Changes in Etanercept and Adalimumab Biosimilar Prescriptions for the Initial Treatment of Rheumatoid Arthritis in France: Data from the ART-SFR Registry

Author

Ruyssen-Witrand, Adeline, primary, Boudali, Yacine, additional, Pane, Isabelle, additional, Cantagrel, Alain, additional, Thevenot, Pascale, additional, Soubrier, Martin, additional, Morel, Jacques, additional, Houvenagel, Eric, additional, Saraux, Alain, additional, Basch, André, additional, Truchetet, Marie-Elise, additional, Marotte, Hubert, additional, Dernis, Emmanuelle, additional, Claudepierre, Pascal, additional, Flipo, René-Marc, additional, Gottenberg, Jacques-Eric, additional, Ravaud, Philippe, additional, Mariette, Xavier, additional, and Seror, Raphaele, additional

Published
2021
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169. Un homme nommé Bach.

Author

Cantagrel, Gilles

Subjects
PORTRAITS, WINES, COMPOSERS, MYTHOLOGY
Abstract

The article presents the discussion on unveiling the true portrait of Johann Sebastian Bach. Topics include Bach indulged in the pleasures of drinking wine or beer, which further humanize the image of the revered composer; and intricacies of these clues and testimonies, dispelling the myths and presenting a more authentic portrayal of the man behind the legend.

Published
2023

171. Stratégies de sevrage des antalgiques opioïdes faibles : étude comparative des pratiques des médecins exerçant en médecine de la douleur et des addictions

Author

N. Cantagrel, G. Roche, Nicolas Authier, A. Roussin, Chouki Chenaf, and Noémie Delage

Subjects
03 medical and health sciences, 0302 clinical medicine, Anesthesiology and Pain Medicine, 030212 general & internal medicine, 030226 pharmacology & pharmacy
Abstract

Le sevrage d’antalgique opioïde peut nécessiter le recours à un médecin spécialisé dans la prise en charge de la douleur et/ou des addictions. Cette enquête sur les modalités de sevrage de la codéine, du tramadol et de la poudre d’opium a mis en évidence des différences de pratique des médecins selon leur spécialité. La diminution des doses était plus rapide pour les patients douloureux consultant un algologue. Dans leur ensemble, les résultats obtenus devraient aider à l’élaboration de recommandations sur les modalités de sevrage des antalgiques opioïdes.

Published
2019
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172. Prevalence of inflammatory posterior arch abnormalities on lumbar spine MRI in spondyloarthritis patients compared with low back pain patients

Author

Adeline Ruyssen-Witrand, Clément Geniez, Hélène Braun, Marie Faruch-Bilfeld, Alain Cantagrel, Nicolas Sans, Delphine Nigon, Arnaud Constantin, and Yannick Degboé

Subjects
Adult, Male, musculoskeletal diseases, medicine.medical_specialty, Arthritis, 030218 nuclear medicine & medical imaging, Facet joint, Costotransverse joint, 03 medical and health sciences, 0302 clinical medicine, Spondylarthritis, Prevalence, medicine, Edema, Humans, Radiology, Nuclear Medicine and imaging, Spondylitis, Retrospective Studies, Neuroradiology, Inflammation, Lumbar Vertebrae, medicine.diagnostic_test, business.industry, Sacroiliitis, Magnetic resonance imaging, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Low back pain, medicine.anatomical_structure, Case-Control Studies, 030220 oncology & carcinogenesis, Female, Radiology, medicine.symptom, business, Low Back Pain
Abstract

This study was conducted in order to compare the prevalence of inflammatory posterior arch abnormalities on lumbar spine MRI between axial spondyloarthritis (axSpA) patients and low back pain (LBP) patients. Patients—axSpA patients meeting the 2009 ASAS criteria and chronic LBP patients who had a lumbar spine MRI were selected. MRI—STIR and T1 sagittal images up to T8–T9 were reviewed by two experienced rheumatologists blinded to the diagnosis and clinical data to identify inflammatory posterior arch abnormalities. Analyses—The prevalence of inflammatory posterior arch abnormalities between axSpA and LBP patients was compared. Clinical data were compared in the axSpA group depending on whether or not inflammatory posterior arch abnormalities were present. Ninety-five patients were enrolled in each group. The prevalence of all inflammatory posterior arch abnormalities was the same in the axSpA and LBP groups (58% in the SpA group versus 70% in the LBP group, p = 0.1). However, differences in terms of the prevalence of costotransverse joint arthritis, pedicle oedema above L3 and transverse and spinous process oedema were observed between the two groups (axSpA 27% versus LBP 6%, p = 0.0004). Patients with inflammatory posterior arch abnormalities in the axSpA group had a longer disease duration (11 versus 8 years, p = 0.02), higher CRP levels (median 11 versus 3 mg/l, p = 0.0002) and higher prevalence of radiographic sacroiliitis (84 versus 47%, p = 0.001) compared to patients without inflammatory posterior arch abnormalities. Costotransverse arthritis, pedicle oedema and transverse process oedema are more frequent in axSpA patients than LBP patients, on lumbar spine MRI depicting TH9-S1. • MRI pedicle oedema above L3, transverse process oedema, spinous process oedema or costotransverse arthritis is more frequently observed in axial spondyloarthritis (SpA). • SpA patients with at least one MRI inflammatory lesion on the posterior arch had higher clinical activity scores and biological inflammation. • Facet joint arthritis was more common in patients with chronic low back pain.

Published
2019
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173. Update of French society for rheumatology recommendations for managing rheumatoid arthritis

Author

Cécile Gaujoux-Viala, Madeleine Dubremetz, Maxime Dougados, Bruno Fautrel, C. Hua, Nathalie Nayral, Alain Saraux, Christophe Richez, Bernard Combe, Alain Cantagrel, Daniel Wendling, Xavier Mariette, Claire Daien, Gérard Thibaud, Laure Gossec, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Service de Rhumatologie [CHRU Nîmes], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Department of Rheumatology, Purpan Toulouse, Association Française des Polyarthritiques (AFPric), Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de rhumatologie [CHU Pitié Salpêtrière] (GRC-08 EEMOIS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de rhumatologie, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, CHU Bordeaux [Bordeaux], Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), ANDAR patient organisation, Paris, Service de Rhumatologie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Rhumatologie [CHU Pitié Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Lymphocytes B, Autoimmunité et Immunothérapies (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Association Nationale de Défense contre l'Arthrite Rhumatoide (ANDAR), CCSD, Accord Elsevier, Hôpital Bicêtre-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), and Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM)

Subjects
Male, medicine.medical_specialty, [SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Recommendations, Targeted therapy, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Targeted treatment, Internal medicine, Diagnosis, medicine, Humans, 030212 general & internal medicine, Practice Patterns, Physicians', Rheumatoid arthritis, Intensive care medicine, Societies, Medical, 030203 arthritis & rheumatology, business.industry, Task force, Disease Management, Diagnostic strategy, medicine.disease, 3. Good health, Patient management, [SDV] Life Sciences [q-bio], Treatment, DMARD, Systematic review, Antirheumatic Agents, Practice Guidelines as Topic, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Methotrexate, France, Rheumatologists, business, Forecasting, medicine.drug
Abstract

International audience; The 2014 French Society for Rheumatology (Société Française de Rheumatologie, SFR) recommendations about the management of rheumatoid arthritis (RA) have been updated by a task force composed of 12 expert rheumatologists, 2 patient self-help group representatives, and an occupational therapist. The material used by the task force included recent EULAR recommendations, a systematic literature review, and expert opinion. Four general principles and 15 recommendations were developed. The general principles emphasize the need for shared decision-making between the rheumatologist and the patient and for a global management program including both pharmacological and non-pharmacological treatments. The recommendations deal with the diagnostic strategy for RA, treatment targets, management organization, drug selection based on the treatment line and prognostic factors, management of remissions, and global patient management. Disease-modifying anti-rheumatic drug (DMARD) therapy should be started as early as possible. Validated composite scores should be determined at regular intervals to assess disease activity - according to the tight disease control concept - to achieve the treatment target, i.e., a remission. Methotrexate is the recommended first-line DMARD. The treatment should be optimized when methotrexate is poorly tolerated or inadequately effective. While waiting for conventional synthetic DMARDs to take effect, glucocorticoid therapy can be used, for a brief period to keep the cumulative dose low. When a sustained remission without structural progression is achieved in a patient who is not taking glucocorticoid therapy, targeted therapy de-escalation according to tight disease control principles should be considered. Patients should be periodically screened for comorbidities and their risk factors, which should be evaluated and treated.

Published
2019
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174. Association between IL23R and ERAP1 polymorphisms and sacroiliac or spinal MRI inflammation in spondyloarthritis: DESIR cohort data

Author

Cécile Luxembourger, Pascal Claudepierre, Arnaud Constantin, Delphine Nigon, Alain Cantagrel, Yannick Degboé, Adeline Ruyssen-Witrand, CHU Toulouse [Toulouse], Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Epidemiology in Dermatology and Evaluation in Therapeutics (EpiDermE), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Henri Mondor, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)

Subjects
Adult, Male, 0301 basic medicine, musculoskeletal diseases, medicine.medical_specialty, lcsh:Diseases of the musculoskeletal system, Population, Single-nucleotide polymorphism, Aminopeptidases, Polymorphism, Single Nucleotide, Gastroenterology, Cohort Studies, Minor Histocompatibility Antigens, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Internal medicine, Spondylarthritis, Spondyloarthritis, medicine, Humans, Longitudinal Studies, Prospective Studies, Sacroiliitis, education, BASDAI, Genetic Association Studies, 030203 arthritis & rheumatology, Sacroiliac joint, education.field_of_study, Ankylosing spondylitis, business.industry, Sacroiliac Joint, Receptors, Interleukin, medicine.disease, Magnetic Resonance Imaging, Spine, Rheumatology, 030104 developmental biology, medicine.anatomical_structure, Cohort, Female, lcsh:RC925-935, business, Polymorphisms, Research Article
Abstract

Background To investigate the association between 12 single nucleotide polymorphisms (SNPs) located on ERAP1 and IL23R with the presence of inflammation on the sacroiliac joint (SIJ) or spinal magnetic resonance imagery (MRI) in an early onset spondyloarthritis (SpA) cohort. Methods All the patients included in the DESIR cohort with an axial SpA and available DNA at baseline were enrolled in this study (n = 645 patients) and underwent a clinical examination, CRP assay, SIJ and spinal MRI scans. Six SNPs located on ERAP1 (rs30187, rs27044, rs27434, rs17482078, rs10050860, rs2287987) and six SNPs located on IL23R (rs1004819, rs10489629, rs1343151, rs2201841, rs10889677, rs11209032) were genotyped. Univariable analyses were performed to test the association between the genotypes and SIJ and spinal MRI inflammation, as well as disease activity based on Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score-C-Reactive Protein (ASDAS-CRP) and CRP. Results One SNP located on ERAP1 (rs27434) and haplotype CCT of ERAP1 were associated with SIJ inflammation detected by MRI, but these associations were below the Bonferroni corrected threshold of significance. However, one SNP (rs1004819) located on IL23R was associated with SIJ MRI inflammation (rs1004819: TT 42.3%, CT 40.5%, CC 26.5%, p = 0.0005). This locus was also significantly associated with Spondyloarthritis Research Consortium of Canada scores while no association with another inflammatory parameter such as BASDAI, ASDAS-CRP, CRP or Berlin MRI score was identified in this population. Conclusion One locus of the IL23R gene was associated with SIJ MRI inflammation and might be a marker of more active disease in recent onset SpA. Trial registration clinicaltrials.gov, NCTO 164 8907

Published
2019
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175. Serum Fatty Acid Profiles Are Associated with Disease Activity in Early Rheumatoid Arthritis: Results from the ESPOIR Cohort

Author

Johanna Sigaux, Alice Bellicha, Camille Buscail, Chantal Julia, René-Marc Flipo, Alain Cantagrel, Francois Laporte, Caroline Beal, Marie-Christophe Boissier, and Luca Semerano

Subjects
Arthritis, Rheumatoid, Cohort Studies, Nutrition and Dietetics, Fatty Acids, Fatty Acids, Omega-3, Humans, Prospective Studies, omega 3 fatty acids, n-3 fatty acids, omega 6 fatty acids, n-6 fatty acids rheumatoid arthritis, cohort study, Food Science
Abstract

Background: Long-chain omega-3 and omega-6 fatty acids (n-3, n-6 FAs) may modulate inflammation and affect the risk of developing rheumatoid arthritis (RA). However, whether n-3/n-6 FA status affects RA after disease onset is unknown. This study aimed to assess whether FA profiles are independently associated with disease activity in a large prospective cohort of patients with early RA. Methods: Baseline serum FAs were quantified in 669 patients in the ESPOIR cohort. Principal component analysis identified three serum FA patterns that were rich in n-7–9, n-3 and n-6 FAs (patterns ω7–9, ω3 and ω6), respectively. The association of pattern tertiles with baseline variables and 6-month disease activity was tested using multivariable logistic regression. Results: Pattern ω3 was associated with low baseline and pattern ω6 with high baseline C-reactive protein level and disease activity. Both patterns ω3 and ω6 were associated with reduced odds of active disease after 6 months of follow-up (pattern ω3: odds ratio, tertile three vs. one, 0.49 [95% CI 0.25 to 0.97] and pattern ω6: 0.51 [0.28 to 0.95]; p = 0.04 and 0.03, respectively). Conclusions: In a cohort of early RA patients, a serum lipid profile rich in n-3 FAs was independently associated with persistently reduced disease activity between baseline and 6-month follow-up. An n-6 FA profile was also associated with lower 6-month disease activity.

Published
2022
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177. Prognosis and follow-up of psoriatic arthritis with peripheral joint involvement: Development of recommendations for clinical practice based on published evidence and expert opinion

Author

Lavie, Frédéric, Salliot, Carine, Dernis, Emmanuelle, Claudepierre, Pascal, Schaeverbeke, Thierry, Tebib, Jacques, Goupille, Philippe, Cantagrel, Alain, Flipo, René-Marc, Gaudin, Philippe, Le Loët, Xavier, Maillefert, Jean-Francis, Paul, Carle, Saraux, Alain, Wendling, Daniel, and Combe, Bernard

Published
2009
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178. Pharmacological treatment (biotherapy excluded) of peripheral psoriatic arthritis: Development of recommendations for clinical practice based on data from the literature and experts opinion

Author

Dernis, Emmanuelle, Lavie, Frédéric, Salliot, Carine, Flipo, René-Marc, Saraux, Alain, Maillefert, Jean-Francis, Paul, Carle, Goupille, Philippe, Cantagrel, Alain, Claudepierre, Pascal, Gaudin, Philippe, Tebib, Jacques, Wendling, Daniel, Schaeverbeke, Thierry, Le Loët, Xavier, and Combe, Bernard

Published
2009
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182. Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene

Author

Gazal, Steven, Sacre, Karim, Allanore, Yannick, Teruel, Maria, Goodall, Alison H, Tohma, Shigeto, Alfredsson, Lars, Okada, Yukinori, Xie, Gang, Constantin, Arnaud, Balsa, Alejandro, Kawasaki, Aya, Nicaise, Pascale, Amos, Christopher, Rodriguez-Rodriguez, Luis, Chiocchia, Gilles, Boileau, Catherine, Zhang, Jinyi, Vittecoq, Olivier, Barnetche, Thomas, Gay, Miguel A Gonzalez, Furukawa, Hiroshi, Cantagrel, Alain, Le Loët, Xavier, Sumida, Takayuki, Hurtado-Nedelec, Margarita, Richez, Christophe, Chollet-Martin, Sylvie, Schaeverbeke, Thierry, Combe, Bernard, Khoryati, Liliane, Coustet, Baptiste, El-Benna, Jammel, Siminovitch, Katherine, Plenge, Robert, Padyukov, Leonid, Martin, Javier, Tsuchiya, Naoyuki, and Dieudé, Philippe

Published
2015
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