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151. Dinge

Author

Begemann, Christian, Begemann, Christian, editor, and Giuriato, Davide, editor

Published
2017
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152. Einzelne Erzählungen

Author

Frei Gerlach, Franziska, Begemann, Christian, Giuriato, Davide, von Arburg, Hans-Georg, Hahn, Marcus, Geulen, Eva, Wünsch, Marianne, Koschorke, Albrecht, Begemann, Christian, editor, and Giuriato, Davide, editor

Published
2017
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153. »Bunte Steine«

Author

Schneider, Sabine, Begemann, Christian, Twellmann, Marcus, Öhlschläger, Claudia, Albrecht, Tim, Gamper, Michael, Vogel, Juliane, Begemann, Christian, editor, and Giuriato, Davide, editor

Published
2017
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154. »Studien«

Author

Hettche, Walter, Schößler, Franziska, Eßlinger, Eva, Lukas, Wolfgang, von Arburg, Hans-Georg, Geulen, Eva, Blasberg, Cornelia, Kuhn, Heribert, Begemann, Christian, Neymeyr, Barbara, Bachmann, Vera, Schiffermüller, Isolde, Begemann, Christian, editor, and Giuriato, Davide, editor

Published
2017
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155. Interference effects in the Coulomb blockade regime: current blocking and spin preparation in symmetric nanojunctions

Author

Donarini, Andrea, Begemann, Georg, and Grifoni, Milena

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We consider nanojunctions in the single-electron tunnelling regime which, due to a high degree of spatial symmetry, have a degenerate many body spectrum. As a consequence, interference phenomena which cause a current blocking can occur at specific values of the bias and gate voltage. We present here a general formalism to give necessary and sufficient conditions for interference blockade also in the presence of spin polarized leads. As an example we analyze a triple quantum dot single electron transistor (SET). For a set-up with parallel polarized leads, we show how to selectively prepare the system in each of the three states of an excited spin triplet without application of any external magnetic field., Comment: 10 pages, 9 figures. Corrected typos and updated references

Published
2010
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156. Inelastic cotunneling in quantum dots and molecules with weakly broken degeneracies

Author

Begemann, Georg, Koller, Sonja, Grifoni, Milena, and Paaske, Jens

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We calculate the nonlinear cotunneling conductance through interacting quantum dot systems in the deep Coulomb blockade regime using a rate equation approach based on the T-matrix formalism, which shows in the concerned regions very good agreement with a generalized master equation approach. Our focus is on inelastic cotunneling in systems with weakly broken degeneracies, such as complex quantum dots or molecules. We find for these systems a characteristic gate dependence of the non-equilibrium cotunneling conductance. While on one side of a Coulomb diamond the conductance decreases after the inelastic cotunneling threshold towards its saturation value, on the other side it increases monotonously even after the threshold. We show that this behavior originates from an asymmetric gate voltage dependence of the effective cotunneling amplitudes., Comment: 12 pages, 12 figures; revised published version

Published
2010
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157. All-electric-spin control in interference single electron transistors

Author

Donarini, Andrea, Begemann, Georg, and Grifoni, Milena

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Single particle interference lies at the heart of quantum mechanics. The archetypal double-slit experiment has been repeated with electrons in vacuum up to the more massive $C_{60}$ molecules. Mesoscopic rings threaded by a magnetic flux provide the solid-state analogous. Intra-molecular interference has been recently discussed in molecular junctions. Here we propose to exploit interference to achieve all-electrical control of a single electron spin in quantum dots, a highly desirable property for spintronics and spin-qubit applications. The device consists of an interference single electron transistor (ISET), where destructive interference between orbitally degenerate electronic states produces current blocking at specific bias voltages. We show that in the presence of parallel polarized ferromagnetic leads the interplay between interference and the exchange coupling on the system generates an effective energy renormalization yielding different blocking biases for majority and minority spins. Hence, by tuning the bias voltage full control over the spin of the trapped electron is achieved., Comment: 9 pages, 5 figures

Published
2009
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158. To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis: HAMLETT, a pragmatic multicenter single-blind randomized controlled trial

Author

Marieke J. H. Begemann, Ilse A. Thompson, Wim Veling, Shiral S. Gangadin, Chris N. W. Geraets, Erna van ‘t Hag, Sanne J. Müller-Kuperus, Priscilla P. Oomen, Alban E. Voppel, Mark van der Gaag, Martijn J. Kikkert, Jim Van Os, H. Filip E. Smit, Rikus H. Knegtering, Sybren Wiersma, Luyken H. Stouten, Harm J. Gijsman, Lex Wunderink, Anton B. P. Staring, Selene R. T. Veerman, Amrita G. S. Mahabir, Jörg Kurkamp, Gerdina H. M. Pijnenborg, Natalie D. Veen, Machteld Marcelis, Koen P. Grootens, Gunnar Faber, Nico J. van Beveren, Agaath Been, Truus van den Brink, Maarten Bak, Therese A. M. J. van Amelsvoort, Andrea Ruissen, Christine Blanke, Karin Groen, Lieuwe de Haan, and Iris E. C. Sommer

Subjects
Antipsychotic medication, first episode psychosis, Maintenance, Treatment, Discontinuation, Tapering, global functioning, Randomized controlled trial, Medicine (General), R5-920
Abstract

Abstract Background Antipsychotic medication is effective for symptomatic treatment in schizophrenia-spectrum disorders. After symptom remission, continuation of antipsychotic treatment is associated with lower relapse rates and lower symptom severity compared to dose reduction/discontinuation. Therefore, most guidelines recommend continuation of treatment with antipsychotic medication for at least 1 year. Recently, however, these guidelines have been questioned as one study has shown that more patients achieved long-term functional remission in an early discontinuation condition—a finding that was not replicated in another recently published long-term study. Methods/design The HAMLETT (Handling Antipsychotic Medication Long-term Evaluation of Targeted Treatment) study is a multicenter pragmatic single-blind randomized controlled trial in two parallel conditions (1:1) investigating the effects of continuation versus dose-reduction/discontinuation of antipsychotic medication after remission of a first episode of psychosis (FEP) on personal and social functioning, psychotic symptom severity, and health-related quality of life. In total 512 participants will be included, aged between 16 and 60 years, in symptomatic remission from a FEP for 3–6 months, and for whom psychosis was not associated with severe or life-threatening self-harm or violence. Recruitment will take place at 24 Dutch sites. Patients are randomized (1:1) to: continuation of antipsychotic medication until at least 1 year after remission (original dose allowing a maximum reduction of 25%, or another antipsychotic drug in similar dose range); or gradual dose reduction till eventual discontinuation of antipsychotics according to a tapering schedule. If signs of relapse occur in this arm, medication dose can be increased again. Measurements are conducted at baseline, at 3, and 6 months post-baseline, and yearly during a follow-up period of 4 years. Discussion The HAMLETT study will offer evidence to guide patients and clinicians regarding questions concerning optimal treatment duration and when to taper off medication after remission of a FEP. Moreover, it may provide patient characteristics associated with safe dose reduction with a minimal risk of relapse. Trial status Protocol version 1.3, October 2018. The study is active and currently recruiting patients (since September 2017), with the first 200 participants by the end of 2019. We anticipate completing recruitment in 2022 and final assessments (including follow-up 3.5 years after phase one) in 2026. Trial registration European Clinical Trials Database, EudraCT number 2017-002406-12. Registered 7 June 2017.

Published
2020
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164. Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

Author

Gusev, Alexander, Lee, S Hong, Trynka, Gosia, Finucane, Hilary, Vilhjálmsson, Bjarni J, Xu, Han, Zang, Chongzhi, Ripke, Stephan, Bulik-Sullivan, Brendan, Stahl, Eli, Kähler, Anna K, Hultman, Christina M, Purcell, Shaun M, McCarroll, Steven A, Daly, Mark J, Pasaniuc, Bogdan, Sullivan, Patrick F, Neale, Benjamin M, Wray, Naomi R, Raychaudhuri, Soumya, Price, Alkes, Corvin, Aiden, Walters, James TR, Farh, Kai-How, Holmans, Peter A, Lee, Phil, Collier, David A, Huang, Hailiang, Pers, Tune H, Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A, Begemann, Martin, Belliveau, Richard A, Bene, Judit, Bergen, Sarah E, Bevilacqua, Elizabeth, Bigdeli, Tim B, Black, Donald W, Børglum, Anders D, Bruggeman, Richard, Buccola, Nancy G, Buckner, Randy L, Byerley, William, Cahn, Wiepke, Cai, Guiqing, Campion, Dominique, Cantor, Rita M, Carr, Vaughan J, Carrera, Noa, Catts, Stanley V, Chambert, Kimberly D, Chan, Raymond CK, Chen, Ronald YL, Chen, Eric YH, Cheng, Wei, Cheung, Eric FC, Chong, Siow Ann, Cloninger, C Robert, Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J, Curtis, David, Davidson, Michael, Davis, Kenneth L, Degenhardt, Franziska, Del Favero, Jurgen, DeLisi, Lynn E, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H, Farrell, Martilias S, Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B, Friedl, Marion, Friedman, Joseph I, Fromer, Menachem, Genovese, Giulio, and Georgieva, Lyudmila

Subjects
Epidemiology, Biological Sciences, Health Sciences, Genetics, Human Genome, Prevention, Computer Simulation, Genetic Diseases, Inborn, Genetic Variation, Genome-Wide Association Study, Humans, Inheritance Patterns, Models, Genetic, Open Reading Frames, Regulatory Elements, Transcriptional, Schizophrenia Working Group of the Psychiatric Genomics Consortium, SWE-SCZ Consortium, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Regulatory and coding variants are known to be enriched with associations identified by genome-wide association studies (GWASs) of complex disease, but their contributions to trait heritability are currently unknown. We applied variance-component methods to imputed genotype data for 11 common diseases to partition the heritability explained by genotyped SNPs (hg(2)) across functional categories (while accounting for shared variance due to linkage disequilibrium). Extensive simulations showed that in contrast to current estimates from GWAS summary statistics, the variance-component approach partitions heritability accurately under a wide range of complex-disease architectures. Across the 11 diseases DNaseI hypersensitivity sites (DHSs) from 217 cell types spanned 16% of imputed SNPs (and 24% of genotyped SNPs) but explained an average of 79% (SE = 8%) of hg(2) from imputed SNPs (5.1× enrichment; p = 3.7 × 10(-17)) and 38% (SE = 4%) of hg(2) from genotyped SNPs (1.6× enrichment, p = 1.0 × 10(-4)). Further enrichment was observed at enhancer DHSs and cell-type-specific DHSs. In contrast, coding variants, which span 1% of the genome, explained

Published
2014

165. Biological insights from 108 schizophrenia-associated genetic loci

Author

Ripke, Stephan, Neale, Benjamin M, Corvin, Aiden, Walters, James TR, Farh, Kai-How, Holmans, Peter A, Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A, Huang, Hailiang, Pers, Tune H, Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A, Begemann, Martin, Belliveau, Richard A Jr, Bene, Judit, Bergen, Sarah E, Bevilacqua, Elizabeth, Bigdeli, Tim B, Black, Donald W, Bruggeman, Richard, Buccola, Nancy G, Buckner, Randy L, Byerley, William, Cahn, Wiepke, Cai, Guiqing, Campion, Dominique, Cantor, Rita M, Carr, Vaughan J, Carrera, Noa, Catts, Stanley V, Chambert, Kimberly D, Chan, Raymond CK, Chen, Ronald YL, Chen, Eric YH, Cheng, Wei, Cheung, Eric FC, Chong, Siow Ann, Cloninger, C Robert, Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J, Curtis, David, Davidson, Michael, Davis, Kenneth L, Degenhardt, Franziska, Del Favero, Jurgen, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H, Farrell, Martilias S, Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B, Friedl, Marion, Friedman, Joseph I, Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Giegling, Ina, Giusti-Rodriguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I, Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, de Haan, Lieuwe, Hammer, Christian, Hamshere, Marian L, Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M, Henskens, Frans A, Herms, Stefan, Hirschhorn, Joel N, Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V, Hougaard, David M, Ikeda, Masashi, and Joa, Inge

Subjects
Human Genome, Brain Disorders, Serious Mental Illness, Prevention, Schizophrenia, Genetics, Neurosciences, Mental Health, 2.1 Biological and endogenous factors, Aetiology, Mental health, Alleles, Brain, Enhancer Elements, Genetic, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Glutamic Acid, Humans, Immunity, Multifactorial Inheritance, Mutation, Odds Ratio, Polymorphism, Single Nucleotide, Synaptic Transmission, Schizophrenia Working Group of the Psychiatric Genomics Consortium, General Science & Technology
Abstract

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.

Published
2014

166. Enabling and constraining factors of remote informal communication: a socio-technical systems perspective.

Author

Begemann, Vanessa, Handke, Lisa, and Lehmann-Willenbrock, Nale

Subjects
FLEXIBLE work arrangements, TELECOMMUTING, SOCIOTECHNICAL systems, BUSINESS communication, TELECOMMUNICATION systems
Abstract

Informal interactions are vital in daily workplace communication, shaping performance, well-being, collaboration, and overall organizational functioning. However, as the ongoing trends of remote and hybrid work present significant changes and challenges to these interactions, supporting remote informal communication (RIC) becomes urgent. To address this pressing issue, we adopt a socio-technical systems perspective to gain in-depth insights into the enabling and constraining factors related to RIC. Our findings of semi-structured interviews with working adults (N=33) reveal important changes and challenges related to informal communication in the remote work context. We identify eleven interrelated socio-contextual, intrapersonal, and technological factors, culminating in a comprehensive conceptual framework of RIC. Based on our findings, we provide practical recommendations to effectively facilitate RIC in organizations and discuss future research avenues for understanding effective RIC in organizations. [ABSTRACT FROM AUTHOR]

Published
2024
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169. A benzene interference single-electron transistor

Author

Darau, D., Begemann, G., Donarini, A., and Grifoni, M.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Interference effects strongly affect the transport characteristics of a benzene single-electron transistor (SET) and for this reason we call it interference SET (I-SET). We focus on the effects of degeneracies between many-body states of the isolated benzene. We show that the particular current blocking and selective conductance suppression occurring in the benzene I-SET are due to interference effects between the orbitally degenerate states. Further we study the impact of reduced symmetry due to anchor groups or potential drop over the molecule. We identify in the quasi-degeneracy of the involved molecular states the necessary condition for the robustness of the results., Comment: 17pages, 9 figures, revised version

Published
2008
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170. Symmetry fingerprints of a benzene single-electron transistor

Author

Begemann, Georg, Darau, Dana, Donarini, Andrea, and Grifoni, Milena

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

The interplay between Coulomb interaction and orbital symmetry produces specific transport characteristics in molecular single electron transistors (SET) that can be considered as the fingerprints of the contacted molecule. Specifically we predict, for a benzene SET, selective conductance suppression and the appearance of negative differential conductance when changing the contacts from para to meta configuration. Both effects originate from destructive interference in transport involving states with orbital degeneracy., Comment: 4 pages, 4 figures

Published
2008
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172. Transport through a double quantum dot system with non-collinearly polarized leads

Author

Hornberger, Ralph Peter, Koller, Sonja, Begemann, Georg, Donarini, Andrea, and Grifoni, Milena

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

We investigate linear and non-linear transport in a double quantum dot system weakly coupled to spin-polarized leads. In the linear regime, the conductance as well as the non-equilibrium spin accumulation are evaluated in analytic form. The conductance as a function of the gate voltage exhibits four peaks of different height, with mirror symmetry with respect to the charge neutrality point. As the polarization angle is varied, the position and shape of the peaks changes in a characteristic way which preserves the electron-hole symmetry of the problem. In the nonlinear regime negative differential conductance features occur for non collinear magnetisations of the leads. In the considered sequential tunneling limit, the tunneling magneto resistance (TMR) is always positive with a characteristic gate voltage dependence for non-collinear magnetization. If a magnetic field is added to the system, the TMR can become negative., Comment: 18 pages, 13 figures, 5 tables; revised published version

Published
2007
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173. Source shape determination with directional fragment-fragment velocity correlations

Author

Fevre, A. Le, Schwarz, C., Auger, G., Begemann-Blaich, M. L., Bellaize, N., Bittiger, R., Bocage, F., Borderie, B., Bougault, R., Bouriquet, B., Charvet, J. L., Chbihi, A., Dayras, R., Durand, D., Frankland, J. D., Galichet, E., Gourio, D., Guinet, D., Hudan, S., Lautesse, P., Lavaud, F., Legrain, R., Lopez, O., Lukasik, J., Lynen, U., Mueller, W. F. J., Nalpas, L., Orth, H., Plagnol, E., Rosato, E., Saija, A., Sfienti, C., Tamain, B., Trautmann, W., Trzcinski, A., Turzo, K., Vient, E., Vigilante, M., Volant, C., and Zwieglinski, B.

Subjects
Nuclear Experiment
Abstract

Correlation functions, constructed from directional projections of the relative velocities of fragments, are used to determine the shape of the breakup volume in coordinate space. For central collisions of 129Xe + natSn at 50 MeV per nucleon incident energy, measured with the 4pi multi-detector INDRA at GSI, a prolate shape aligned along the beam direction with an axis ratio of 1:0.7 is deduced. The sensitivity of the method is discussed in comparison with conventional fragment-fragment velocity correlations., Comment: 12 pages, 5 figures, subm. to Phys. Lett. B

Published
2007
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174. Thermal and Chemical Freeze-out in Spectator Fragmentation

Author

Trautmann, W., Bassini, R., Begemann-Blaich, M., Ferrero, A., Fritz, S., Gaff-Ejakov, S. J., Gross, C., Imme, G., Iori, I., and Kleinevoss, U.

Subjects
Nuclear Experiment
Abstract

Isotope temperatures from double ratios of hydrogen, helium, lithium, beryllium, and carbon isotopic yields, and excited-state temperatures from yield ratios of particle-unstable resonances in 4He, 5Li, and 8Be, were determined for spectator fragmentation, following collisions of 197Au with targets ranging from C to Au at incident energies of 600 and 1000 MeV per nucleon. A deviation of the isotopic from the excited-state temperatures is observed which coincides with the transition from residue formation to multi-fragment production, suggesting a chemical freeze-out prior to thermal freeze-out in bulk disintegrations., Comment: 14 pages, 10 figures, submitted to Phys. Rev. C, small changes as suggested by the editors and referees

Published
2007
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181. Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Author

Ruderfer, Douglas M., Ripke, Stephan, McQuillin, Andrew, Boocock, James, Stahl, Eli A., Pavlides, Jennifer M. Whitehead, Mullins, Niamh, Charney, Alexander W., Ori, Anil P.S., Loohuis, Loes M. Olde, Domenici, Enrico, Di Florio, Arianna, Papiol, Sergi, Kalman, Janos L., Trubetskoy, Vassily, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Akil, Huda, Albani, Diego, Albus, Margot, Alda, Martin, Alexander, Madeline, Alliey-Rodriguez, Ney, Als, Thomas D., Amin, Farooq, Anjorin, Adebayo, Arranz, Maria J., Awasthi, Swapnil, Bacanu, Silviu A., Badner, Judith A., Baekvad-Hansen, Marie, Bakker, Steven, Band, Gavin, Barchas, Jack D., Barroso, Ines, Bass, Nicholas, Bauer, Michael, Baune, Bernhard T., Begemann, Martin, Bellenguez, Celine, Belliveau, Richard A., Jr., Bellivier, Frank, Bender, Stephan, Bene, Judit, Bergen, Sarah E., Berrettini, Wade H., Bevilacqua, Elizabeth, Biernacka, Joanna M., Bigdeli, Tim B., Black, Donald W., Blackburn, Hannah, Blackwell, Jenefer M., Blackwood, Douglas H.R., Pedersen, Carsten Bocker, Boehnke, Michael, Boks, Marco, Borglum, Anders D., Bramon, Elvira, Breen, Gerome, Brown, Matthew A., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Budde, Monika, Bulik-Sullivan, Brendan, Bumpstead, Suzannah J., Bunney, William, Burmeister, Margit, Buxbaum, Joseph D., Bybjerg-Grauholm, Jonas, Byerley, William, Cahn, Wiepke, Cai, Guiqing, Cairns, Murray J., Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Casas, Juan P., Casas, Miquel, Catts, Stanley V., Cervantes, Pablo, Chambert, Kimberley D., Chan, Raymond C.K., Chen, Eric Y.H., Chen, Ronald Y.L., Cheng, Wei, Cheung, Eric F.C., Chong, Siow Ann, Clarke, Toni-Kim, Cloninger, C. Robert, Cohen, David, Cohen, Nadine, Coleman, Jonathan R.I., Collier, David A., Cormican, Paul, Coryell, William, Craddock, Nicholas, Craig, David W., Crespo-Facorro, Benedicto, Crowley, James J., Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M., Dale, Anders M., Daly, Mark J., Dannlowski, Udo, Darvasi, Ariel, Davidson, Michael, Davis, Kenneth L., de Leeuw, Christiaan A., Degenhardt, Franziska, Del Favero, Jurgen, DeLisi, Lynn E., Deloukas, Panos, Demontis, Ditte, DePaulo, J. Raymond, di Forti, Marta, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Dobbyn, Amanda L., Donnelly, Peter, Donohoe, Gary, Drapeau, Elodie, Dronov, Serge, Duan, Jubao, Dudbridge, Frank, Duncanson, Audrey, Edenberg, Howard, Edkins, Sarah, Ehrenreich, Hannelore, Eichhammer, Peter, Elvsashagen, Torbjorn, Eriksson, Johan, Escott-Price, Valentina, Esko, Tonu, Essioux, Laurent, Etain, Bruno, Fan, Chun Chieh, Farh, Kai-How, Farrell, Martilias S., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Frank, Josef, Franke, Lude, Fraser, Christine, Freedman, Robert, Freeman, Colin, Freimer, Nelson B., Friedman, Joseph I., Fromer, Menachem, Frye, Mark A., Fullerton, Janice M., Gade, Katrin, Garnham, Julie, Gaspar, Helena A., Gejman, Pablo V., Genovese, Giulio, Georgieva, Lyudmila, Giambartolomei, Claudia, Giannoulatou, Eleni, Giegling, Ina, Gill, Michael, Gillman, Matthew, Pedersen, Marianne Giortz, Giusti-Rodriguez, Paola, Godard, Stephanie, Goes, Fernando, Goldstein, Jacqueline I., Gopal, Srihari, Gordon, Scott D., Gordon-Smith, Katherine, Gratten, Jacob, Gray, Emma, Green, Elaine K., Green, Melissa J., Greenwood, Tiffany A., Grigoroiu-Serbanescu, Maria, Grove, Jakob, Guan, Weihua, Gurling, Hugh, Parra, Jose Guzman, Gwilliam, Rhian, de Haan, Lieuwe, Hall, Jeremy, Hall, Mei-Hua, Hammer, Christian, Hammond, Naomi, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M., Hauser, Joanna, Hautzinger, Martin, Heilbronner, Urs, Hellenthal, Garrett, Henskens, Frans A., Herms, Stefan, Hipolito, Maria, Hirschhorn, Joel N., Hoffmann, Per, Hollegaard, Mads V., Hougaard, David M., Huang, Hailiang, Huckins, Laura, Hultman, Christina M., Hunt, Sarah E., Ikeda, Masashi, Iwata, Nakao, Iyegbe, Conrad, Jablensky, Assen V., Jamain, Stephane, Jankowski, Janusz, Jayakumar, Alagurevathi, Joa, Inge, Jones, Ian, Jones, Lisa A., Jonsson, Erik G., Julia, Antonio, Jureus, Anders, Kahler, Anna K., Kahn, Rene S., Kalaydjieva, Luba, Kandaswamy, Radhika, Karachanak-Yankova, Sena, Karjalainen, Juha, Karlsson, Robert, Kavanagh, David, Keller, Matthew C., Kelly, Brian J., Kelsoe, John, Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, Kirov, George, Kittel-Schneider, Sarah, Klovins, Janis, Knight, Jo, Knott, Sarah V., Knowles, James A., Kogevinas, Manolis, Konte, Bettina, Kravariti, Eugenia, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kupka, Ralph, Kuzelova-Ptackova, Hana, Landen, Mikael, Langford, Cordelia, Laurent, Claudine, Lawrence, Jacob, Lawrie, Stephen, Lawson, William B., Leber, Markus, Leboyer, Marion, Lee, Phil H., Keong, Jimmy Lee Chee, Legge, Sophie E., Lencz, Todd, Lerer, Bernard, Levinson, Douglas F., Levy, Shawn E., Lewis, Cathryn M., Li, Jun Z., Li, Miaoxin, Li, Qingqin S., Li, Tao, Liang, Kung-Yee, Liddle, Jennifer, Lieberman, Jeffrey, Limborska, Svetlana, Lin, Kuang, Linszen, Don H., Lissowska, Jolanta, Liu, Chunyu, Liu, Jianjun, Lonnqvist, Jouko, Loughland, Carmel M., Lubinski, Jan, Lucae, Susanne, Macek, Milan, Jr., MacIntyre, Donald J., Magnusson, Patrik K.E., Maher, Brion S., Mahon, Pamela B., Maier, Wolfgang, Malhotra, Anil K., Mallet, Jacques, Malt, Ulrik F., Markus, Hugh S., Marsal, Sara, Martin, Nicholas G., Mata, Ignacio, Mathew, Christopher G., Mattheisen, Manuel, Mattingsdal, Morten, Mayoral, Fermin, McCann, Owen T., McCarley, Robert W., McCarroll, Steven A., McCarthy, Mark I., McDonald, Colm, McElroy, Susan L., McGuffin, Peter, McInnis, Melvin G., McIntosh, Andrew M., McKay, James D., McMahon, Francis J., Medeiros, Helena, Medland, Sarah E., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Melle, Ingrid, Meng, Fan, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mitchell, Philip B., Mokrab, Younes, Montgomery, Grant W., Moran, Jennifer L., Morken, Gunnar, Morris, Derek W., Mors, Ole, Mortensen, Preben B., Mowry, Bryan J., Mühleisen, Thomas W., Müller-Myhsok, Bertram, Murphy, Kieran C., Murray, Robin M., Myers, Richard M., Myin-Germeys, Inez, Neale, Benjamin M., Nelis, Mari, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Nievergelt, Caroline M., Nikitina-Zake, Liene, Nimgaonkar, Vishwajit, Nisenbaum, Laura, Nordentoft, Merete, Nordin, Annelie, Nöthen, Markus M., Nwulia, Evaristus A., O’Callaghan, Eadbhard, O’Donovan, Claire, O’Dushlaine, Colm, O’Neill, F. Anthony, Oedegaard, Ketil J., Oh, Sang-Yun, Olincy, Ann, Olsen, Line, Oruc, Lilijana, Van Os, Jim, Owen, Michael J., Paciga, Sara A., Palmer, Colin N.A., Palotie, Aarno, Pantelis, Christos, Papadimitriou, George N., Parkhomenko, Elena, Pato, Carlos, Pato, Michele T., Paunio, Tiina, Pearson, Richard, Perkins, Diana O., Perlis, Roy H., Perry, Amy, Pers, Tune H., Petryshen, Tracey L., Pfennig, Andrea, Picchioni, Marco, Pietilainen, Olli, Pimm, Jonathan, Pirinen, Matti, Plomin, Robert, Pocklington, Andrew J., Posthuma, Danielle, Potash, James B., Potter, Simon C., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Ramos-Quiroga, Josep Antoni, Rasmussen, Henrik B., Rautanen, Anna, Ravindrarajah, Radhi, Regeer, Eline J., Reichenberg, Abraham, Reif, Andreas, Reimers, Mark A., Ribases, Marta, Rice, John P., Richards, Alexander L., Ricketts, Michelle, Riley, Brien P., Rivas, Fabio, Rivera, Margarita, Roffman, Joshua L., Rouleau, Guy A., Roussos, Panos, Rujescu, Dan, Salomaa, Veikko, Sanchez-Mora, Cristina, Sanders, Alan R., Sawcer, Stephen J., Schall, Ulrich, Schatzberg, Alan F., Scheftner, William A., Schofield, Peter R., Schork, Nicholas J., Schwab, Sibylle G., Scolnick, Edward M., Scott, Laura J., Scott, Rodney J., Seidman, Larry J., Serretti, Alessandro, Sham, Pak C., Weickert, Cynthia Shannon, Shehktman, Tatyana, Shi, Jianxin, Shilling, Paul D., Sigurdsson, Engilbert, Silverman, Jeremy M., Sim, Kang, Slaney, Claire, Slominsky, Petr, Smeland, Olav B., Smoller, Jordan W., So, Hon-Cheong, Sobell, Janet L., Soderman, Erik, Hansen, Christine Soholm, Spencer, Chris C.A., Spijker, Anne T., St Clair, David, Stefansson, Hreinn, Stefansson, Kari, Steinberg, Stacy, Stogmann, Elisabeth, Stordal, Eystein, Strange, Amy, Straub, Richard E., Strauss, John S., Streit, Fabian, Strengman, Eric, Strohmaier, Jana, Stroup, T. Scott, Su, Zhan, Subramaniam, Mythily, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Szelinger, Szabolcs, Tashakkori-Ghanbaria, Avazeh, Thirumalai, Srinivas, Thompson, Robert C., Thorgeirsson, Thorgeir E., Toncheva, Draga, Tooney, Paul A., Tosato, Sarah, Toulopoulou, Timothea, Trembath, Richard C., Treutlein, Jens, Turecki, Gustavo, Vaaler, Arne E., Vedder, Helmut, Vieta, Eduard, Vincent, John, Visscher, Peter M., Viswanathan, Ananth C., Vukcevic, Damjan, Waddington, John, Waller, Matthew, Walsh, Dermot, Walshe, Muriel, Walters, James T.R., Wang, Dai, Wang, Qiang, Wang, Weiqing, Wang, Yunpeng, Watson, Stanley J., Webb, Bradley T., Weickert, Thomas W., Weinberger, Daniel R., Weisbrod, Matthias, Weiser, Mark, Werge, Thomas, Weston, Paul, Whittaker, Pamela, Widaa, Sara, Wiersma, Durk, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Witt, Stephanie H., Wolen, Aaron R., Wong, Emily H.M., Wood, Nicholas W., Wormley, Brandon K., Wu, Jing Qin, Xi, Simon, Xu, Wei, Young, Allan H., Zai, Clement C., Zandi, Peter, Zhang, Peng, Zheng, Xuebin, Zimprich, Fritz, Zollner, Sebastian, Corvin, Aiden, Fanous, Ayman H., Cichon, Sven, Rietschel, Marcella, Gershon, Elliot S., Schulze, Thomas G., Cuellar-Barboza, Alfredo B., Forstner, Andreas J., Holmans, Peter A., Nurnberger, John I., Andreassen, Ole A., Lee, S. Hong, O’Donovan, Michael C., Sullivan, Patrick F., Ophoff, Roel A., Wray, Naomi R., Sklar, Pamela, and Kendler, Kenneth S.

Published
2018
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184. Directed and elliptic flow in Au + Au at intermediate energies

Author

Lukasik, J., Auger, G., Begemann-Blaich, M. L., Bellaize, N., Bittiger, R., Bocage, F., Borderie, B., Bougault, R., Bouriquet, B., Charvet, J. L., Chbihi, A., Dayras, R., Durand, D., Frankland, J. D., Galichet, E., Gourio, D., Guinet, D., Hudan, S., Lautesse, P., Lavaud, F., Fevre, A. Le, Legrain, R., Lopez, O., Lynen, U., Mueller, W. F. J., Nalpas, L., Orth, H., Plagnol, E., Rosato, E., Saija, A., Schwarz, C., Sfienti, C., Tamain, B., Trautmann, W., Trzcinski, A., Turzo, K., Vient, E., Vigilante, M., Volant, C., and Zwieglinski, B.

Subjects
Nuclear Experiment
Abstract

Directed and elliptic flow for the Au + Au system at incident energies between 40 and 150 MeV per nucleon has been measured using the INDRA 4 pi multi-detector. For semi-central collisions, the elliptic flow of Z <= 2 particles switches from in-plane to out-of-plane enhancement at around 100 MeV per nucleon, in good agreement with the result reported by the FOPI Collaboration. The directed flow changes sign at a bombarding energy between 50 and 60 MeV per nucleon and remains negative at lower energies. The conditions for the appearance and possible origins of negative flow are discussed., Comment: 12 pages, 6 eps figures, elsart, submitted to Phys. Lett. B

Published
2004
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185. Isotopic Scaling and the Symmetry Energy in Spectator Fragmentation

Author

INDRA, The, Collaborations, ALADIN, Fèvre, A. Le, Auger, G., Begemann-Blaich, M. L., Bellaize, N., Bittiger, R., Bocage, F., Borderie, B., Bougault, R., Bouriquet, B., Charvet, J. L., Chbihi, A., Dayras, R., Durand, D., Frankland, J. D., Galichet, E., Gourio, D., Guinet, D., Hudan, S., Immé, G., Lautesse, P., Lavaud, F., Legrain, R., Lopez, O., Łukasik, J., Lynen, U., Müller, W. F. J., Nalpas, L., Orth, H., Plagnol, E., Raciti, G., Rosato, E., Saija, A., Schwarz, C., Seidel, W., Sfienti, C., Tamain, B., Trautmann, W., Trzciński, A., Turzó, K., Vient, E., Vigilante, M., Volant, C., Zwiegliński, B., and Botvina, A. S.

Subjects
Nuclear Experiment
Abstract

Isotopic effects in the fragmentation of excited target residues following collisions of $^{12}$C on $^{112,124}$Sn at incident energies of 300 and 600 MeV per nucleon were studied with the INDRA 4$\pi$ detector. The measured yield ratios for light particles and fragments with atomic number $Z \leq$ 5 obey the exponential law of isotopic scaling. The deduced scaling parameters decrease strongly with increasing centrality to values smaller than 50% of those obtained for the peripheral event groups. Symmetry term coefficients, deduced from these data within the statistical description of isotopic scaling, are near $\gamma =$ 25 MeV for peripheral and $\gamma <$ 15 MeV for central collisions., Comment: 4 pages, 4 figures

Published
2004
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186. Model-independent tracking of criticality signals in nuclear multifragmentation data

Author

Frankland, J. D., Chbihi, A., Mignon, A., Begemann-Blaich, M. L., Bittiger, R., Borderie, B., Bougault, R., Charvet, J. -L., Cussol, D., Dayras, R., Durand, D., Escano-Rodriguez, C., Galichet, E., Guinet, D., Lautesse, P., Fevre, A. Le, Legrain, R., Neindre, N. Le, Lopez, O., Lukasik, J., Lynen, U., Manduci, L., Marie, J., Muller, W. F. J., Orth, H., Parlog, M., Pichon, M., Rivet, M. F., Rosato, E., Roy, R., Saija, A., Schwarz, C., Sfienti, C., Tamain, B., Trautmann, W., Trzcinski, A., Turzo, K., Van Lauwe, A., Vigilante, M., Volant, C., Wieleczko, J. P., Zwieglinski, B., Vient, E., and Nalpas, L.

Subjects
Nuclear Experiment
Abstract

We look for signals of criticality in multifragment production in heavy-ion collisions using model-independent universal fluctuations theory. The phenomenon is studied as a function of system size, bombarding energy, and impact parameter in a wide range of INDRA data. For very central collisions (b/b_max

Published
2004
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187. Multiplicity correlations of intermediate-mass fragments with pions and fast protons in 12C + 197Au

Author

Turzo, K., Auger, G., Begemann-Blaich, M. L., Bellaize, N., Bittiger, R., Bocage, F., Borderie, B., Bougault, R., Bouriquet, B., and Charvet, J. L.

Subjects
Nuclear Experiment
Abstract

Low-energy pi+ (E < 35 MeV) from 12C+197Au collisions at incident energies from 300 to 1800 MeV per nucleon were detected with the Si-Si(Li)-CsI(Tl) calibration telescopes of the INDRA multidetector. The inclusive angular distributions are approximately isotropic, consistent with multiple rescattering in the target spectator. The multiplicity correlations of the low-energy pions and of energetic protons (E > 150 MeV) with intermediate-mass fragments were determined from the measured coincidence data. The deduced correlation functions 1 + R \approx 1.3 for inclusive event samples reflect the strong correlations evident from the common impact-parameter dependence of the considered multiplicities. For narrow impact-parameter bins (based on charged-particle multiplicity), the correlation functions are close to unity and do not indicate strong additional correlations. Only for pions at high particle multiplicities (central collisions) a weak anticorrelation is observed, probably due to a limited competition between these emissions. Overall, the results are consistent with the equilibrium assumption made in statistical multifragmentation scenarios. Predictions obtained with intranuclear cascade models coupled to the Statistical Multifragmentation Model are in good agreement with the experimental data., Comment: 9 pages, 11 figures, subm. to EPJA

Published
2004
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188. Statistical Multifragmentation of Non-Spherical Expanding Sources in Central Heavy-Ion Collisions

Author

Fevre, A. Le, Ploszajczak, M., Toneev, V. D., Auger, G., Begemann-Blaich, M. L., Bellaize, N., Bittiger, R., Bocage, F., Borderie, B., and Bougault, R.

Subjects
Nuclear Experiment
Abstract

We study the anisotropy effects measured with INDRA at GSI in central collisions of Xe+Sn at 50 A.MeV and Au+Au at 60, 80, 100 A.MeV incident energy. The microcanonical multifragmentation model with non-spherical sources is used to simulate an incomplete shape relaxation of the multifragmenting system. This model is employed to interpret observed anisotropic distributions in the fragment size and mean kinetic energy. The data can be well reproduced if an expanding prolate source aligned along the beam direction is assumed. An either non-Hubblean or non-isotropic radial expansion is required to describe the fragment kinetic energies and their anisotropy. The qualitative similarity of the results for the studied reactions suggests that the concept of a longitudinally elongated freeze-out configuration is generally applicable for central collisions of heavy systems. The deformation decreases slightly with increasing beam energy., Comment: 35 pages, 19 figures, submitted to Nuclear Physics A

Published
2003
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189. Fragmentation in Peripheral Heavy-Ion Collisions: from Neck Emission to Spectator Decays

Author

Lukasik, J., Auger, G., Begemann-Blaich, M. L., Bellaize, N., Bittiger, R., Bocage, F., Borderie, B., Bougault, R., Bouriquet, B., Charvet, J. L., Chbihi, A., Dayras, R., Durand, D., Frankland, J. D., Galichet, E., Gourio, D., Guinet, D., Hudan, S., Hurst, B., Lautesse, P., Lavaud, F., Fevre, A. Le, Legrain, R., Lopez, O., Lynen, U., Mueller, W. F. J., Nalpas, L., Orth, H., Plagnol, E., Rosato, E., Saija, A., Schwarz, C., Sfienti, C., Steckmeyer, J. C., Tamain, B., Trautmann, W., Trzcinski, A., Turzo, K., Vient, E., Vigilante, M., Volant, C., Zwieglinski, B., and Botvina, A. S.

Subjects
Nuclear Experiment
Abstract

Invariant cross sections of intermediate mass fragments in peripheral collisions of Au on Au at incident energies between 40 and 150 AMeV have been measured with the 4-pi multi-detector INDRA. The maximum of the fragment production is located near mid-rapidity at the lower energies and moves gradually towards the projectile and target rapidities as the energy is increased. Schematic calculations within an extended Goldhaber model suggest that the observed cross-section distributions and their evolution with energy are predominantly the result of the clustering requirement for the emerging fragments and of their Coulomb repulsion from the projectile and target residues. The quantitative comparison with transverse energy spectra and fragment charge distributions emphasizes the role of hard scattered nucleons in the fragmentation process., Comment: 5 pages, 5 eps figures, RevTeX4, submitted to Phys. Lett. B

Published
2003
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193. Violent aggression predicted by multiple pre-adult environmental hits

Author

Mitjans, Marina, Seidel, Jan, Begemann, Martin, Bockhop, Fabian, Moya-Higueras, Jorge, Bansal, Vikas, Wesolowski, Janina, Seelbach, Anna, Ibáñez, Manuel Ignacio, Kovacevic, Fatka, Duvar, Oguzhan, Fañanás, Lourdes, Wolf, Hannah-Ulrike, Ortet, Generós, Zwanzger, Peter, Klein, Verena, Lange, Ina, Tänzer, Andreas, Dudeck, Manuela, Penke, Lars, van Elst, Ludger Tebartz, Bittner, Robert A., Schmidmeier, Richard, Freese, Roland, Müller-Isberner, Rüdiger, Wiltfang, Jens, Bliesener, Thomas, Bonn, Stefan, Poustka, Luise, Müller, Jürgen L., Arias, Bárbara, and Ehrenreich, Hannelore

Published
2019
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194. Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model

Author

Pan, Hong, Oliveira, Bárbara, Saher, Gesine, Dere, Ekrem, Tapken, Daniel, Mitjans, Marina, Seidel, Jan, Wesolowski, Janina, Wakhloo, Debia, Klein-Schmidt, Christina, Ronnenberg, Anja, Schwabe, Kerstin, Trippe, Ralf, Mätz-Rensing, Kerstin, Berghoff, Stefan, Al-Krinawe, Yazeed, Martens, Henrik, Begemann, Martin, Stöcker, Winfried, Kaup, Franz-Josef, Mischke, Reinhard, Boretius, Susann, Nave, Klaus-Armin, Krauss, Joachim K., Hollmann, Michael, Lühder, Fred, and Ehrenreich, Hannelore

Published
2019
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197. Spatially clustering de novo variants in CYFIP2, encoding the cytoplasmic FMRP interacting protein 2, cause intellectual disability and seizures

Author

Zweier, Markus, Begemann, Anaïs, McWalter, Kirsty, Cho, Megan T., Abela, Lucia, Banka, Siddharth, Behring, Bettina, Berger, Andrea, Brown, Chester W., Carneiro, Maryline, Chen, Jiani, Cooper, Gregory M., Deciphering Developmental Disorders (DDD) Study, Finnila, Candice R., Guillen Sacoto, Maria J., Henderson, Alex, Hüffmeier, Ulrike, Joset, Pascal, Kerr, Bronwyn, Lesca, Gaetan, Leszinski, Gloria S., McDermott, John Henry, Meltzer, Meira R., Monaghan, Kristin G., Mostafavi, Roya, Õunap, Katrin, Plecko, Barbara, Powis, Zöe, Purcarin, Gabriela, Reimand, Tiia, Riedhammer, Korbinian M., Schreiber, John M., Sirsi, Deepa, Wierenga, Klaas J., Wojcik, Monica H., Papuc, Sorina M., Steindl, Katharina, Sticht, Heinrich, and Rauch, Anita

Published
2019
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198. De novo truncating variants in the intronless IRF2BPL are responsible for developmental epileptic encephalopathy

Author

Tran Mau-Them, F., Guibaud, L., Duplomb, L., Keren, B., Lindstrom, K., Marey, I., Mochel, F., van den Boogaard, M. J., Oegema, R., Nava, C., Masurel, A., Jouan, T., Jansen, F. E., Au, M., Chen, Agnes H., Cho, M., Duffourd, Y., Lozier, E., Konovalov, F., Sharkov, A., Korostelev, S., Urteaga, B., Dickson, P., Vera, M., Martínez-Agosto, Julián A., Begemann, A., Zweier, M., Schmitt-Mechelke, T., Rauch, A., Philippe, C., van Gassen, K., Nelson, S., Graham, Jr, J. M., Friedman, J., Faivre, L., Lin, H. J., Thauvin-Robinet, C., and Vitobello, A.

Published
2019
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199. Transverse Velocity Scaling in Au+Au Fragmentation

Author

Lukasik, J., Hudan, S., Lavaud, F., Turzo, K., Auger, G., Bacri, Ch. O., Begemann-Blaich, M. L., Bellaize, N., Bittiger, R., Bocage, F., Borderie, B., Buchet, P., Bougault, R., Bouriquet, B., Charvet, J. L., Chbihi, A., Dayras, R., Durand, D., Dore, D., Frankland, J. D., Galichet, E., Gourio, D., Guinet, D., Hurst, B., Leduc, C., Lautesse, P., Laville, J. L., Fevre, A. Le, Legrain, R., Lynen, U., Mueller, W. F. J., Lopez, O., Nalpas, L., Orth, H., Plagnol, E., Rosato, E., Saija, A., Tabacaru, G., Sfienti, C., Schwarz, C., Steckmeyer, J. C., Tamain, B., Trautmann, W., Vient, E., Trzcinski, A., Vigilante, M., Volant, C., Zwieglinski, B., and Botvina, A. S.

Subjects
Nuclear Experiment
Abstract

Invariant transverse-velocity spectra of intermediate-mass fragments were measured with the 4-pi multi-detector system INDRA for collisions of Au on Au at incident energies between 40 and 150 MeV per nucleon. Their scaling properties as a function of incident energy and atomic number Z are used to distinguish and characterize the emissions in (i) peripheral collisions at the projectile and target rapidities, and in (ii) central and (iii) peripheral collisions near mid-rapidity. The importance of dynamical effects is evident in all three cases and their origin is discussed., Comment: 4 pages, 3 eps figures, RevTeX4, submitted to Phys. Rev

Published
2002
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200. Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis

Author

Martin de Jonge, Albert Batalla, Gerdina H. M. Pijnenborg, Jim van Os, Iris E. C. Sommer, Elske Willemse, Sybren Wiersma, Therese van Amelsvoort, Truus van den Brink, Marieke J. H. Begemann, Joran Lokkerbol, Shiral S. Gangadin, Maarten Bak, Sinan Guloksuz, Amrita G.S. Mahabir, P. Roberto Bakker, Martijn J. Kikkert, G. Faber, Nynke Boonstra, Marinte van den Bosch, Koen P. Grootens, Agaath Been, Franciska de Beer, Yudith R A Haveman, Wim Veling, Bodyl A Brand, Jörg Kurkamp, Sanne Koops, Filip Smit, Tonnie Staring, Nico J.M. van Beveren, Erna van ‘t Hag, Machteld Marcelis, Chris N W Geraets, A E Voppel, Natalie D. Veen, Inge van der Heijden, Selene R. T. Veerman, Priscilla P. Oomen, Lieuwe de Haan, Rikus Knegtering, Ellen Graveland, Bram-Sieben Rosema, Joelle Hoornaar, Psychiatry 1, RS: MHeNs - R3 - Neuroscience, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, Psychiatry 3, and MUMC+: MA Med Staf Spec Psychiatrie (9)

Subjects
cognition, Psychosis, SYMPTOMS, global functioning, Clustering, functional outcome, DEFICITS, First episode psychosis, SCHIZOPHRENIA, medicine, HETEROGENEITY, psychosis, PREDICTORS, Applied Psychology, METAANALYSIS, SCALE, business.industry, Cognition, PERFORMANCE, medicine.disease, FEP, Outcome (probability), Large sample, Psychiatry and Mental health, Schizophrenia, RELIABILITY, business, ASSESSMENT SCHEDULE 2.0, Clinical psychology
Abstract

BackgroundCognitive deficits may be characteristic for only a subgroup of first-episode psychosis (FEP) and the link with clinical and functional outcomes is less profound than previously thought. This study aimed to identify cognitive subgroups in a large sample of FEP using a clustering approach with healthy controls as a reference group, subsequently linking cognitive subgroups to clinical and functional outcomes.Methods204 FEP patients were included. Hierarchical cluster analysis was performed using baseline brief assessment of cognition in schizophrenia (BACS). Cognitive subgroups were compared to 40 controls and linked to longitudinal clinical and functional outcomes (PANSS, GAF, self-reported WHODAS 2.0) up to 12-month follow-up.ResultsThree distinct cognitive clusters emerged: relative to controls, we found one cluster with preserved cognition (n = 76), one moderately impaired cluster (n = 74) and one severely impaired cluster (n = 54). Patients with severely impaired cognition had more severe clinical symptoms at baseline, 6- and 12-month follow-up as compared to patients with preserved cognition. General functioning (GAF) in the severely impaired cluster was significantly lower than in those with preserved cognition at baseline and showed trend-level effects at 6- and 12-month follow-up. No significant differences in self-reported functional outcome (WHODAS 2.0) were present.ConclusionsCurrent results demonstrate the existence of three distinct cognitive subgroups, corresponding with clinical outcome at baseline, 6- and 12-month follow-up. Importantly, the cognitively preserved subgroup was larger than the severely impaired group. Early identification of discrete cognitive profiles can offer valuable information about the clinical outcome but may not be relevant in predicting self-reported functional outcomes.

Published
2023

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