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1,429 results on '"A, Gubitosi"'

153. Discreteness of area in noncommutative space

Author

Amelino-Camelia, Giovanni, Gubitosi, Giulia, and Mercati, Flavio

Subjects
High Energy Physics - Theory
Abstract

We introduce an area operator for the Moyal noncommutative plane. We find that the spectrum is discrete, but, contrary to the expectation formulated by other authors, not characterized by a "minimum-area principle". We show that an intuitive analysis of the uncertainty relations obtained from Moyal-plane noncommutativity is fully consistent with our results for the spectrum, and we argue that our area operator should be generalizable to several other noncommutative spaces. We also observe that the properties of distances and areas in the Moyal plane expose some weaknesses in the line of reasoning adopted in some of the heuristic analyses of the measurability of geometric spacetime observables in the quantum-gravity realm.

Published
2008
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154. On the distance observable in the Moyal plane and in a novel two-dimensional space with string-theory pregeometry

Author

Amelino-Camelia, Giovanni, Gubitosi, Giulia, and Mercati, Flavio

Subjects
High Energy Physics - Theory, General Relativity and Quantum Cosmology
Abstract

Motivation for the study of spacetime noncommutativity comes primarily from its possible use in investigations of (Planck-scale) spacetime fuzziness, but most work focuses on S-matrix/field-theory observables and still very little has been established for geometric observables. We argue that it might be useful to exploit the "pregeometric" formulation of spacetime noncommutativity, which in particular describes the coordinates of the Moyal plane in terms of the phase-space coordinates of a point particle "living" in a auxiliary/fictitious spacetime ($\{x_1,x_2\}_{Moyal} \equiv \{q,p\}_{particle}$). This leads us straightforwardly to a distance operator for the Moyal plane, and allows us to expose some limitations of a previous attempt to describe the "area of a disc" in the Moyal plane. We also observe that from our pregeometric perspective it is rather natural to contemplate a spacetime whose pregeometric picture is based on the phase-space coordinates (fields) of a string. The fact that such "stringspaces" essentially provide spacetime points with extendedness is relevant for the fuzziness of geometric spacetime observables in ways that we preliminarily characterize through an analysis of the distance observable on a two-dimensional stringspace and through the observation that by implementing the Amati-Ciafaloni-Veneziano/Gross-Mende uncertainty relation in the phase space of the pregeometric string one could have stringspaces with a novel type of fuzzy coordinates., Comment: Latex, 18 pages. Version 2: minor editing of text

Published
2008

157. First results of the Noether theorem for Hopf-algebra spacetime symmetries

Author

Amelino-Camelia, Giovanni, Gubitosi, Giulia, Marciano, Antonino, Martinetti, Pierre, Mercati, Flavio, Pranzetti, Daniele, and Tacchi, Ruggero Altair

Subjects
General Relativity and Quantum Cosmology
Abstract

We summarize here the first results obtained using a technique we recently developed for the Noether analysis of Hopf-algebra spacetime symmetries, including the derivation of conserved charges for field theories in noncommutative spacetimes of canonical or kappa-Minkowski type., Comment: 14 pages, Based in part on the lecture given by G.A.-C. at the 21st Nishinomiya-Yukawa Memorial Symposium "Noncommutative geometry and quantum spacetime in physics", but updated with the results of our recent papers arXiv:0707.1863 arXiv:0709.2063 arXiv:0709.4600

Published
2007
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158. Twisted Hopf symmetries of canonical noncommutative spacetimes and the no-pure-boost principle

Author

Amelino-Camelia, Giovanni, Briscese, Fabio, Gubitosi, Giulia, Marciano, Antonino, Martinetti, Pierre, and Mercati, Flavio

Subjects
High Energy Physics - Theory
Abstract

We study the twisted-Hopf-algebra symmetries of observer-independent canonical spacetime noncommutativity, for which the commutators of the spacetime coordinates take the form [x^{mu},x^{nu}]=i theta^{mu nu} with observer-independent (and coordinate-independent) theta^{mu nu}. We find that it is necessary to introduce nontrivial commutators between transformation parameters and spacetime coordinates, and that the form of these commutators implies that all symmetry transformations must include a translation component. We show that with our noncommutative transformation parameters the Noether analysis of the symmetries is straightforward, and we compare our canonical-noncommutativity results with the structure of the conserved charges and the "no-pure-boost" requirement derived in a previous study of kappa-Minkowski noncommutativity. We also verify that, while at intermediate stages of the analysis we do find terms that depend on the ordering convention adopted in setting up the Weyl map, the final result for the conserved charges is reassuringly independent of the choice of Weyl map and (the corresponding choice of) star product., Comment: 12 pages

Published
2007
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159. A no-pure-boost uncertainty principle from spacetime noncommutativity

Author

Amelino-Camelia, Giovanni, Gubitosi, Giulia, Marcianó, Antonino, Martinetti, Pierre, and Mercati, Flavio

Subjects
High Energy Physics - Theory
Abstract

We study boost and space-rotation transformations in kappa-Minkowski noncommutative spacetime, using the techniques that some of us had previously developed (hep-th/0607221) for a description of translations in kappa-Minkowski, which in particular led to the introduction of translation transformation parameters that do not commute with the spacetime coordinates. We find a similar description of boosts and space rotations, which allows us to identify some associated conserved charges, but the form of the commutators between transformation parameters and spacetime coordinates is incompatible with the possibility of a pure boost., Comment: 8 pages, LaTex

Published
2007
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162. The Impact of Social Interaction Norms and Reward System Norms on Underrepresented Faculty at a Four-Year Public Urban University. A Preliminary Report.

Author

Gubitosi, Annie

Abstract

This study examined how social interaction norms and promotion and tenure norms effected job satisfaction, focusing on how these variables effected on underrepresented faculty at a predominantly white, four-year, public, urban university. Semi-structured in-depth interviews were conducted with a total of nine faculty (white male, white female, and female and male faculty of color), all with eight or fewer years of service at the institution. Several norms emerged from interview questions relating to issues of social interaction and reward systems, including rank-based hierarchy, silence of untenured faculty, middle class culture, individualism, collegiality, the professorial image, the importance of grants and publications, and inadequate salaries. The implications of these norms are discussed in relation to job satisfaction among majority- and minority-group faculty. Recommendations for improving underrepresented faculty satisfaction and retention are included. An appendix provides copies of the original interview protocol, a follow-up interview protocol, and a revised protocol for future interviews. (Contains 46 references.) (MDM)

Published
1996

163. Relationships Between the Cumulative Incidences of Long-term Complications in Type 1 Diabetes: The DCCT/EDIC Study

Author

Ionut, Bebu, Barbara H, Braffett, Ian H, de Boer, Lloyd P, Aiello, John P, Bantle, Gayle M, Lorenzi, William H, Herman, Rose A, Gubitosi-Klug, Bruce A, Perkins, John M, Lachin, and Mark E, Molitch

Subjects
Advanced and Specialized Nursing, Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract

OBJECTIVE To describe the relationships between the cumulative incidences of long-term complications in individuals with type 1 diabetes (T1D) and assess whether observed associations are independent of age, duration of diabetes, and glycemic levels. METHODS Proliferative diabetic retinopathy (PDR), clinically significant macular edema (CSME), reduced estimated glomerular filtration rate (eGFR), amputations, cardiovascular disease (CVD), and mortality were assessed in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study over ∼30 years. RESEARCH DESIGN AND RESULTS The cumulative incidence of complications ranged from 3% (amputations) to 37% (CSME). There were large differences in the cumulative incidence of PDR between participants with versus without prior CSME (66% vs. 15%), reduced eGFR (59% vs. 29%), and amputation (68% vs. 32%); reduced eGFR with or without prior PDR (25% vs. 9%), amputation (48% vs. 13%), and CVD (30% vs. 11%); CVD with or without prior reduced eGFR (37% vs. 14%) and amputation (50% vs. 16%); and mortality with or without prior reduced eGFR (22% vs. 9%), amputation (35% vs. 8%), and CVD (25% vs. 8%). Adjusted for age, duration of T1D, and mean updated HbA1c, the complications and associations with higher risk included PDR with CSME (hazard ratio [HR] 1.88; 95% CI 1.42, 2.50), reduced eGFR (HR 1.41; 95% CI 1.01, 1.97), and CVD (HR 1.43; 95% CI 1.06, 1.92); CSME with higher risk of PDR (HR 3.94; 95% CI 3.18 4.89), reduced eGFR (HR 1.49; 95% CI 1.10, 2.01), and CVD (HR 1.35; 95% CI 1.03, 1.78); reduced eGFR with higher risk of CVD (HR 2.09; 95% CI 1.44, 3.03), and death (HR 3.40; 95% CI 2.35, 4.92); amputation(s) with death (HR 2.97; 95% CI 1.70, 2.90); and CVD with reduced eGFR (HR 1.59; 95% CI 1.08, 2.34) and death (HR 1.95; 95% CI 1.32, 2.90). CONCLUSIONS Long-term micro- and macrovascular complications and mortality are highly correlated. Age, diabetes duration, and glycemic levels do not completely explain these associations.

Published
2022

165. The κ-Newtonian and κ-Carrollian algebras and their noncommutative spacetimes

Author

Angel Ballesteros, Giulia Gubitosi, Ivan Gutierrez-Sagredo, and Francisco J. Herranz

Subjects
Quantum groups, Carroll, Newton–Hooke, Anti-de Sitter, Kappa-deformation, Noncommutative spaces, Physics, QC1-999
Abstract

We derive the non-relativistic c→∞ and ultra-relativistic c→0 limits of the κ-deformed symmetries and corresponding spacetime in (3+1) dimensions, with and without a cosmological constant. We apply the theory of Lie bialgebra contractions to the Poisson version of the κ-(A)dS quantum algebra, and quantize the resulting contracted Poisson–Hopf algebras, thus giving rise to the κ-deformation of the Newtonian (Newton–Hooke and Galilei) and Carrollian (Para-Poincaré, Para-Euclidean and Carroll) quantum symmetries, including their deformed quadratic Casimir operators. The corresponding κ-Newtonian and κ-Carrollian noncommutative spacetimes are also obtained as the non-relativistic and ultra-relativistic limits of the κ-(A)dS noncommutative spacetime. These constructions allow us to analyze the non-trivial interplay between the quantum deformation parameter κ, the curvature parameter η and the speed of light parameter c.

Published
2020
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167. Diffeomorphisms in Momentum Space: Physical Implications of Different Choices of Momentum Coordinates in the Galilean Snyder Model

Author

Giulia Gubitosi and Salvatore Mignemi

Subjects
noncommutative geometry, quantum spacetime, deformed quantum mechanics, Elementary particle physics, QC793-793.5
Abstract

It has been pointed out that different choices of momenta can be associated to the same noncommutative spacetime model. The question of whether these momentum spaces, related by diffeomorphisms, produce the same physical predictions is still debated. In this work, we focus our attention on a few different momentum spaces that can be associated to the Galilean Snyder noncommutative spacetime model and show that they produce different predictions for the energy spectrum of the harmonic oscillator.

Published
2022
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168. Comparing Two Approaches for Thyroidectomy: A Health Technology Assessment through DMAIC Cycle

Author

Carlo Ricciardi, Adelmo Gubitosi, Donatella Vecchione, Giuseppe Cesarelli, Francesco De Nola, Roberto Ruggiero, Ludovico Docimo, and Giovanni Improta

Subjects
health technology assessment, Six Sigma, DMAIC, thyroidectomy, Medicine
Abstract

Total thyroidectomy is very common in endocrine surgery and the haemostasis can be obtained in different ways across surgery; recently, some devices have been developed to support this surgical phase. In this paper, a health technology assessment is conducted through the define, measure, analyse, improve, and control cycle of the Six Sigma methodology to compare traditional total thyroidectomy with the surgical operation performed through a new device in an overall population of 104 patients. Length of hospital stay, drain output, and time for surgery were considered the critical to qualities in order to compare the surgical approaches which can be considered equal regarding the organizational, ethical, and security impact. Statistical tests (Kolmogorov–Smirnov, t test, ANOVA, Mann–Whitney, and Kruskal–Wallis tests) and visual management diagrams were employed to compare the approaches, but no statistically significant difference was found between them. Considering these results, this study shows that the introduction of the device to perform total thyroidectomy does not guarantee appreciable clinical advantages. A cost analysis to quantify the economic impact of the device into the practice could be a future development. Healthy policy leaders and clinicians who are requested to make decisions regarding the supply of biomedical technologies could benefit from this research.

Published
2022
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169. Thermal and spectral dimension of (generalized) Snyder noncommutative spacetimes

Author

Giovanni Amelino-Camelia, Flaminia Giacomini, and Giulia Gubitosi

Subjects
Physics, QC1-999
Abstract

We report an investigation of the Snyder noncommutative spacetime and of some of its most natural generalizations, also looking at them as a powerful tool for comparing different notions of dimensionality of a quantum spacetime. It is known that (generalized-)Snyder noncommutativity, while having rich off-shell implications (kinematical Hilbert space), does not affect noninteracting on-shell particles (physical Hilbert space), and we argue that physically meaningful notions of dimensionality should describe such spacetimes as trivially four-dimensional, without any running with scales. By studying the thermodynamics of a gas of massless particles living on these spacetimes, we find that indeed the Snyder model and its generalizations have constant thermal dimension of four. We also compute the spectral dimension of the Snyder model and its generalizations, finding that, as a result of its sensitivity to off-shell properties, it runs from the standard value of four in the infrared towards lower values in the ultraviolet limit.

Published
2018
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170. Parity at the Planck scale

Author

Michele Arzano, Giulia Gubitosi, and João Magueijo

Subjects
Physics, QC1-999
Abstract

We explore the possibility that well known properties of the parity operator, such as its idempotency and unitarity, might break down at the Planck scale. Parity might then do more than just swap right and left polarized states and reverse the sign of spatial momentum k: it might generate superpositions of right and left handed states, as well as mix momenta of different magnitudes. We lay down the general formalism, but also consider the concrete case of the Planck scale kinematics governed by κ-Poincaré symmetries, where some of the general features highlighted appear explicitly. We explore some of the observational implications for cosmological fluctuations. Different power spectra for right handed and left handed tensor modes might actually be a manifestation of deformed parity symmetry at the Planck scale. Moreover, scale-invariance and parity symmetry appear deeply interconnected. Keywords: Discrete symmetries, Quantum Gravity phenomenology

Published
2018
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172. Interplay between Spacetime Curvature, Speed of Light and Quantum Deformations of Relativistic Symmetries

Author

Angel Ballesteros, Giulia Gubitosi, and Flavio Mercati

Subjects
quantum groups, Poincaré group, (Anti)-de Sitter, Galilei group, carroll symmetries, curvature, Mathematics, QA1-939
Abstract

Recent work showed that κ-deformations can describe the quantum deformation of several relativistic models that have been proposed in the context of quantum gravity phenomenology. Starting from the Poincaré algebra of special-relativistic symmetries, one can toggle the curvature parameter Λ, the Planck scale quantum deformation parameter κ and the speed of light parameter c to move to the well-studied κ-Poincaré algebra, the (quantum) (A)dS algebra, the (quantum) Galilei and Carroll algebras and their curved versions. In this review, we survey the properties and relations of these algebras of relativistic symmetries and their associated noncommutative spacetimes, emphasizing the nontrivial effects of interplay between curvature, quantum deformation and speed of light parameters.

Published
2021
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173. Re-analysis and meta-analysis of summary statistics from gene–environment interaction studies.

Author

Pham, Duy T, Westerman, Kenneth E, Pan, Cong, Chen, Ling, Srinivasan, Shylaja, Isganaitis, Elvira, Vajravelu, Mary Ellen, Bacha, Fida, Chernausek, Steve, Gubitosi-Klug, Rose, Divers, Jasmin, Pihoker, Catherine, Marcovina, Santica M, Manning, Alisa K, and Chen, Han

Subjects
FIXED effects model, GENOME-wide association studies, STATISTICAL models, STATISTICS, ACCOUNTING methods, CONSORTIA
Abstract

Motivation Summary statistics from genome-wide association studies enable many valuable downstream analyses that are more efficient than individual-level data analysis while also reducing privacy concerns. As growing sample sizes enable better-powered analysis of gene–environment interactions, there is a need for gene–environment interaction-specific methods that manipulate and use summary statistics. Results We introduce two tools to facilitate such analysis, with a focus on statistical models containing multiple gene–exposure and/or gene–covariate interaction terms. REGEM (RE-analysis of GEM summary statistics) uses summary statistics from a single, multi-exposure genome-wide interaction study to derive analogous sets of summary statistics with arbitrary sets of exposures and interaction covariate adjustments. METAGEM (META-analysis of GEM summary statistics) extends current fixed-effects meta-analysis models to incorporate multiple exposures from multiple studies. We demonstrate the value and efficiency of these tools by exploring alternative methods of accounting for ancestry-related population stratification in genome-wide interaction study in the UK Biobank as well as by conducting a multi-exposure genome-wide interaction study meta-analysis in cohorts from the diabetes-focused ProDiGY consortium. These programs help to maximize the value of summary statistics from diverse and complex gene–environment interaction studies. Availability and implementation REGEM and METAGEM are open-source projects freely available at https://github.com/large-scale-gxe-methods/REGEM and https://github.com/large-scale-gxe-methods/METAGEM. [ABSTRACT FROM AUTHOR]

Published
2023
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174. The group structure of dynamical transformations between quantum reference frames

Author

Angel Ballesteros, Flaminia Giacomini, and Giulia Gubitosi

Subjects
Physics, QC1-999
Abstract

Recently, it was shown that when reference frames are associated to quantum systems, the transformation laws between such quantum reference frames need to be modified to take into account the quantum and dynamical features of the reference frames. This led to a relational description of the phase space variables of the quantum system of which the quantum reference frames are part of. While such transformations were shown to be symmetries of the system's Hamiltonian, the question remained unanswered as to whether they enjoy a group structure, similar to that of the Galilei group relating classical reference frames in quantum mechanics. In this work, we identify the canonical transformations on the phase space of the quantum systems comprising the quantum reference frames, and show that these transformations close a group structure defined by a Lie algebra, which is different from the usual Galilei algebra of quantum mechanics. We further find that the elements of this new algebra are in fact the building blocks of the quantum reference frames transformations previously identified, which we recover. Finally, we show how the transformations between classical reference frames described by the standard Galilei group symmetries can be obtained from the group of transformations between quantum reference frames by taking the zero limit of the parameter that governs the additional noncommutativity introduced by the quantum nature of inertial transformations.

Published
2021
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175. Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes

Author

Roshandel, Delnaz, Gubitosi-Klug, Rose, Bull, Shelley B., Canty, Angelo J., Pezzolesi, Marcus G., King, George L., Keenan, Hillary A., Snell-Bergeon, Janet K., Maahs, David M., Klein, Ronald, Klein, Barbara E. K., Orchard, Trevor J., Costacou, Tina, Weedon, Michael N., DCCT/EDIC Research Group, Oram, Richard A., and Paterson, Andrew D.

Published
2018
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176. Curved momentum spaces from quantum groups with cosmological constant

Author

Á. Ballesteros, G. Gubitosi, I. Gutiérrez-Sagredo, and F.J. Herranz

Subjects
Physics, QC1-999
Abstract

We bring the concept that quantum symmetries describe theories with nontrivial momentum space properties one step further, looking at quantum symmetries of spacetime in presence of a nonvanishing cosmological constant Λ. In particular, the momentum space associated to the κ-deformation of the de Sitter algebra in (1+1) and (2+1) dimensions is explicitly constructed as a dual Poisson–Lie group manifold parametrized by Λ. Such momentum space includes both the momenta associated to spacetime translations and the ‘hyperbolic’ momenta associated to boost transformations, and has the geometry of (half of) a de Sitter manifold. Known results for the momentum space of the κ-Poincaré algebra are smoothly recovered in the limit Λ→0, where hyperbolic momenta decouple from translational momenta. The approach here presented is general and can be applied to other quantum deformations of kinematical symmetries, including (3+1)-dimensional ones.

Published
2017
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177. Thermal dimension of quantum spacetime

Author

Giovanni Amelino-Camelia, Francesco Brighenti, Giulia Gubitosi, and Grasiele Santos

Subjects
Physics, QC1-999
Abstract

Recent results suggest that a crucial crossroad for quantum gravity is the characterization of the effective dimension of spacetime at short distances, where quantum properties of spacetime become significant. This is relevant in particular for various scenarios of “dynamical dimensional reduction” which have been discussed in the literature. We are here concerned with the fact that the related research effort has been based mostly on analyses of the “spectral dimension”, which involves an unphysical Euclideanization of spacetime and is highly sensitive to the off-shell properties of a theory. As here shown, different formulations of the same physical theory can have wildly different spectral dimension. We propose that dynamical dimensional reduction should be described in terms of the “thermal dimension” which we here introduce, a notion that only depends on the physical content of the theory. We analyze a few models with dynamical reduction both of the spectral dimension and of our thermal dimension, finding in particular some cases where thermal and spectral dimension agree, but also some cases where the spectral dimension has puzzling properties while the thermal dimension gives a different and meaningful picture.

Published
2017
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180. Galilean and -Carrollian noncommutative spaces of worldlines

Author

Angel Ballesteros, Giulia Gubitosi, Ivan Gutierrez-Sagredo, and Francisco J. Herranz

Subjects
Nuclear and High Energy Physics, High Energy Physics - Theory (hep-th), FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), Mathematical Physics (math-ph)
Abstract

The noncommutative spacetimes associated to the $κ$-Poincaré relativistic symmetries and their "non-relativistic" (Galilei) and "ultra-relativistic" (Carroll) limits are indistinguishable, since their coordinates satisfy the same algebra. In this work, we show that the three quantum kinematical models can be differentiated when looking at the associated spaces of time-like worldlines. Specifically, we construct the noncommutative spaces of time-like geodesics with $κ$-Galilei and $κ$-Carroll symmetries as contractions of the corresponding $κ$-Poincaré space and we show that these three spaces are defined by different algebras. In particular, the $κ$-Galilei space of worldlines resembles the so-called Euclidean Snyder model, while the $κ$-Carroll space turns out to be commutative. Furthermore, we identify the map between quantum spaces of geodesics and the corresponding noncommutative spacetimes, which requires to extend the space of geodesics by adding the noncommutative time coordinate.

Published
2023

181. Lunfardo and political (dis)agreements in the public space

Author

Patricia Gubitosi and Irina Lifszyc

Subjects
Cultural Studies, Linguistics and Language, Literature and Literary Theory, Language and Linguistics
Abstract

Linguistic landscapes are useful tools to decipher language ideologies that regulate public spaces in society, helping us to decode the semiotic messages that those landscapes transmit. Urban spaces also reveal social practices that organize people’s lives and unveil social discourses that legitimize, approve, erode, or eliminate different linguistic varieties that struggle to survive. This article examines the use of (mock) Lunfardo, a Spanish urban variety spoken in the Rio de la Plata area, Argentina, in a sign posted by the Buenos Aires’ city authorities and the impact this sign had on social media. The results of the analysis show that appealing to Lunfardo as a symbol of identity failed to establish a conversation between parties within a separated, fractured society.

Published
2022

182. Quantum gravity phenomenology at the dawn of the multi-messenger era—A review

Author

A. Addazi, J. Alvarez-Muniz, R. Alves Batista, G. Amelino-Camelia, V. Antonelli, M. Arzano, M. Asorey, J.-L. Atteia, S. Bahamonde, F. Bajardi, A. Ballesteros, B. Baret, D.M. Barreiros, S. Basilakos, D. Benisty, O. Birnholtz, J.J. Blanco-Pillado, D. Blas, J. Bolmont, D. Boncioli, P. Bosso, G. Calcagni, S. Capozziello, J.M. Carmona, S. Cerci, M. Chernyakova, S. Clesse, J.A.B. Coelho, S.M. Colak, J.L. Cortes, S. Das, V. D’Esposito, M. Demirci, M.G. Di Luca, A. di Matteo, D. Dimitrijevic, G. Djordjevic, D. Dominis Prester, A. Eichhorn, J. Ellis, C. Escamilla-Rivera, G. Fabiano, S.A. Franchino-Viñas, A.M. Frassino, D. Frattulillo, S. Funk, A. Fuster, J. Gamboa, A. Gent, L.Á. Gergely, M. Giammarchi, K. Giesel, J.-F. Glicenstein, J. Gracia-Bondía, R. Gracia-Ruiz, G. Gubitosi, E.I. Guendelman, I. Gutierrez-Sagredo, L. Haegel, S. Heefer, A. Held, F.J. Herranz, T. Hinderer, J.I. Illana, A. Ioannisian, P. Jetzer, F.R. Joaquim, K.-H. Kampert, A. Karasu Uysal, T. Katori, N. Kazarian, D. Kerszberg, J. Kowalski-Glikman, S. Kuroyanagi, C. Lämmerzahl, J. Levi Said, S. Liberati, E. Lim, I.P. Lobo, M. López-Moya, G.G. Luciano, M. Manganaro, A. Marcianò, P. Martín-Moruno, Manel Martinez, Mario Martinez, H. Martínez-Huerta, P. Martínez-Miravé, M. Masip, D. Mattingly, N. Mavromatos, A. Mazumdar, F. Méndez, F. Mercati, S. Micanovic, J. Mielczarek, A.L. Miller, M. Milosevic, D. Minic, L. Miramonti, V.A. Mitsou, P. Moniz, S. Mukherjee, G. Nardini, S. Navas, M. Niechciol, A.B. Nielsen, N.A. Obers, F. Oikonomou, D. Oriti, C.F. Paganini, S. Palomares-Ruiz, R. Pasechnik, V. Pasic, C. Pérez de los Heros, C. Pfeifer, M. Pieroni, T. Piran, A. Platania, S. Rastgoo, J.J. Relancio, M.A. Reyes, A. Ricciardone, M. Risse, M.D. Rodriguez Frias, G. Rosati, D. Rubiera-Garcia, H. Sahlmann, M. Sakellariadou, F. Salamida, E.N. Saridakis, P. Satunin, M. Schiffer, F. Schüssler, G. Sigl, J. Sitarek, J. Solà Peracaula, C.F. Sopuerta, T.P. Sotiriou, M. Spurio, D. Staicova, N. Stergioulas, S. Stoica, J. Strišković, T. Stuttard, D. Sunar Cerci, Y. Tavakoli, C.A. Ternes, T. Terzić, T. Thiemann, P. Tinyakov, M.D.C. Torri, M. Tórtola, C. Trimarelli, T. Trześniewski, A. Tureanu, F.R. Urban, E.C. Vagenas, D. Vernieri, V. Vitagliano, J.-C. Wallet, J.D. Zornoza, Addazi, A., Alvarez-Muniz, J., Alves Batista, R., Amelino-Camelia, G., Antonelli, V., Arzano, M., Asorey, M., Atteia, J. -L., Bahamonde, S., Bajardi, F., Ballesteros, A., Baret, B., Barreiros, D. M., Basilakos, S., Benisty, D., Birnholtz, O., Blanco-Pillado, J. J., Blas, D., Bolmont, J., Boncioli, D., Bosso, P., Calcagni, G., Capozziello, S., Carmona, J. M., Cerci, S., Chernyakova, M., Clesse, S., Coelho, J. A. B., Colak, S. M., Cortes, J. L., Das, S., D'Esposito, V., Demirci, M., Di Luca, M. G., di Matteo, A., Dimitrijevic, D., Djordjevic, G., Prester, D. D., Eichhorn, A., Ellis, J., Escamilla-Rivera, C., Fabiano, G., Franchino-Vinas, S. A., Frassino, A. M., Frattulillo, D., Funk, S., Fuster, A., Gamboa, J., Gent, A., Gergely, L. A., Giammarchi, M., Giesel, K., Glicenstein, J. -F., Gracia-Bondia, J., Gracia-Ruiz, R., Gubitosi, G., Guendelman, E. I., Gutierrez-Sagredo, I., Haegel, L., Heefer, S., Held, A., Herranz, F. J., Hinderer, T., Illana, J. I., Ioannisian, A., Jetzer, P., Joaquim, F. R., Kampert, K. -H., Uysal, A. K., Katori, T., Kazarian, N., Kerszberg, D., Kowalski-Glikman, J., Kuroyanagi, S., Lammerzahl, C., Said, J. L., Liberati, S., Lim, E., Lobo, I. P., Lopez-Moya, M., Luciano, G. G., Manganaro, M., Marciano, A., Martin-Moruno, P., Martinez, M., Martinez-Huerta, H., Martinez-Mirave, P., Masip, M., Mattingly, D., Mavromatos, N., Mazumdar, A., Mendez, F., Mercati, F., Micanovic, S., Mielczarek, J., Miller, A. L., Milosevic, M., Minic, D., Miramonti, L., Mitsou, V. A., Moniz, P., Mukherjee, S., Nardini, G., Navas, S., Niechciol, M., Nielsen, A. B., Obers, N. A., Oikonomou, F., Oriti, D., Paganini, C. F., Palomares-Ruiz, S., Pasechnik, R., Pasic, V., Perez de los Heros, C., Pfeifer, C., Pieroni, M., Piran, T., Platania, A., Rastgoo, S., Relancio, J. J., Reyes, M. A., Ricciardone, A., Risse, M., Frias, M. D. R., Rosati, G., Rubiera-Garcia, D., Sahlmann, H., Sakellariadou, M., Salamida, F., Saridakis, E. N., Satunin, P., Schiffer, M., Schussler, F., Sigl, G., Sitarek, J., Peracaula, J. S., Sopuerta, C. F., Sotiriou, T. P., Spurio, M., Staicova, D., Stergioulas, N., Stoica, S., Striskovic, J., Stuttard, T., Cerci, D. S., Tavakoli, Y., Ternes, C. A., Terzic, T., Thiemann, T., Tinyakov, P., Torri, M. D. C., Tortola, M., Trimarelli, C., Trzesniewski, T., Tureanu, A., Urban, F. R., Vagenas, E. C., Vernieri, D., Vitagliano, V., Wallet, J. -C., Zornoza, J. D., AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), A. Addazi, J. Alvarez-Muniz, R. Alves Batista, G. Amelino-Camelia, V. Antonelli, M. Arzano, M. Asorey, J.-L. Atteia, S. Bahamonde, F. Bajardi, A. Ballestero, B. Baret, D.M. Barreiro, S. Basilako, D. Benisty, O. Birnholtz, J.J. Blanco-Pillado, D. Bla, J. Bolmont, D. Boncioli, P. Bosso, G. Calcagni, S. Capozziello, J.M. Carmona, S. Cerci, M. Chernyakov, S. Clesse, J.A.B. Coelho, S.M. Colak, J.L. Corte, S. Da, V. D???Esposito, M. Demirci, M.G. Di Luca, A. di Matteo, D. Dimitrijevic, G. Djordjevic, D. Dominis Prester, A. Eichhorn, J. Elli, C. Escamilla-Rivera, G. Fabiano, S.A. Franchino-Vi??a, A.M. Frassino, D. Frattulillo, S. Funk, A. Fuster, J. Gamboa, A. Gent, L.??. Gergely, M. Giammarchi, K. Giesel, J.-F. Glicenstein, J. Gracia-Bond??a, R. Gracia-Ruiz, G. Gubitosi, E.I. Guendelman, I. Gutierrez-Sagredo, L. Haegel, S. Heefer, A. Held, F.J. Herranz, T. Hinderer, J.I. Illana, A. Ioannisian, P. Jetzer, F.R. Joaquim, K.-H. Kampert, A. Karasu Uysal, T. Katori, N. Kazarian, D. Kerszberg, J. Kowalski-Glikman, S. Kuroyanagi, C. L??mmerzahl, J. Levi Said, S. Liberati, E. Lim, I.P. Lobo, M. L??pez-Moya, G.G. Luciano, M. Manganaro, A. Marcian??, P. Mart??n-Moruno, Manel Martinez, Mario Martinez, H. Mart??nez-Huerta, P. Mart??nez-Mirav??, M. Masip, D. Mattingly, N. Mavromato, A. Mazumdar, F. M??ndez, F. Mercati, S. Micanovic, J. Mielczarek, A.L. Miller, M. Milosevic, D. Minic, L. Miramonti, V.A. Mitsou, P. Moniz, S. Mukherjee, G. Nardini, S. Nava, M. Niechciol, A.B. Nielsen, N.A. Ober, F. Oikonomou, D. Oriti, C.F. Paganini, S. Palomares-Ruiz, R. Pasechnik, V. Pasic, C. P??rez de los Hero, C. Pfeifer, M. Pieroni, T. Piran, A. Platania, S. Rastgoo, J.J. Relancio, M.A. Reye, A. Ricciardone, M. Risse, M.D. Rodriguez Fria, G. Rosati, D. Rubiera-Garcia, H. Sahlmann, M. Sakellariadou, F. Salamida, E.N. Saridaki, P. Satunin, M. Schiffer, F. Sch??ssler, G. Sigl, J. Sitarek, J. Sol?? Peracaula, C.F. Sopuerta, T.P. Sotiriou, M. Spurio, D. Staicova, N. Stergioula, S. Stoica, J. Stri??kovi??, T. Stuttard, D. Sunar Cerci, Y. Tavakoli, C.A. Terne, T. Terzi??, T. Thiemann, P. Tinyakov, M.D.C. Torri, M. T??rtola, C. Trimarelli, T. Trze??niewski, A. Tureanu, F.R. Urban, E.C. Vagena, D. Vernieri, V. Vitagliano, J.-C. Wallet, J.D. Zornoza, Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Generalitat de Catalunya, European Commission, Xunta de Galicia, Ministerio de Economía y Competitividad (España), European Research Council, Eusko Jaurlaritza, Generalitat Valenciana, Japan Society for the Promotion of Science, and Comunidad de Madrid

Subjects
High Energy Physics - Theory, CAUSAL DYNAMICAL TRIANGULATIONS, Ultra-high-energy cosmic rays, [PHYS.MPHY]Physics [physics]/Mathematical Physics [math-ph], Lorentz invariance violation and deformation, Gamma-ray astronomy, Cosmic neutrinos, Gravitational waves, General Relativity and Quantum Cosmology, Lorentz transformations, Gravitational waves -- Detection, High Energy Physics - Phenomenology (hep-ph), Astronomi, astrofysik och kosmologi, Gamma ray astronomy, Astronomy, Astrophysics and Cosmology, Cosmic neutrino, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), General Relativity and Cosmology, hep-th, hep-ph, Quantum cosmology, ENERGY COSMIC-RAYS, High Energy Physics - Phenomenology, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Neutrinos -- Scattering, Astrophysics - High Energy Astrophysical Phenomena, Particle Physics - Theory, Gravitational wave, ACTIVE GALACTIC NUCLEI, Astrophysics and Astronomy, Nuclear and High Energy Physics, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], gr-qc, FOS: Physical sciences, General Relativity and Quantum Cosmology (gr-qc), GAMMA-RAY BURST, DOUBLY-SPECIAL RELATIVITY, Ultra-high-energy cosmic ray, Particle Physics - Phenomenology, PRIMORDIAL BLACK-HOLES, Matematikk og Naturvitenskap: 400::Fysikk: 430 [VDP], COHERENT STATES GCS, Quantum gravity, GENERALIZED UNCERTAINTY PRINCIPLE, EXTRAGALACTIC BACKGROUND LIGHT, High Energy Physics - Theory (hep-th), [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], LORENTZ INVARIANCE VIOLATION
Abstract

The exploration of the universe has recently entered a new era thanks to the multimessenger paradigm, characterized by a continuous increase in the quantity and quality of experimental data that is obtained by the detection of the various cosmic messengers (photons, neutrinos, cosmic rays and gravitational waves) from numerous origins. They give us information about their sources in the universe and the properties of the intergalactic medium. Moreover, multi-messenger astronomy opens up the possibility to search for phenomenological signatures of quantum gravity. On the one hand, the most energetic events allow us to test our physical theories at energy regimes which are not directly accessible in accelerators; on the other hand, tiny effects in the propagation of very high energy particles could be amplified by cosmological distances. After decades of merely theoretical investigations, the possibility of obtaining phenomenological indications of Planck-scale effects is a revolutionary step in the quest for a quantum theory of gravity, but it requires cooperation between different communities of physicists (both theoretical and experimental). This review, prepared within the COST Action CA18108 ‘‘Quantum gravity phenomenology in the multi-messenger approach", is aimed at promoting this cooperation by giving a state-of-the art account of the interdisciplinary expertise that is needed in the effective search of quantum gravity footprints in the production, propagation and detection of cosmic messengers., Talent Scientific Research Program of College of Physics, Sichuan University 1082204112427, Fostering Program in Disciplines Possessing Novel Features for Natural Science of Sichuan University 2020SCUNL209, 1000 Talent program of Sichuan province 2021, Xunta de Galicia, European Commission European Union ERDF, "Maria de Maeztu'' Units of Excellence program MDM-2016-0692, Red Tematica Nacional de Astroparticulas RED2018-102661-T, La Caixa Foundation 100010434, European Commission 847648 LCF/BQ/PI21/11830030 754510, Ministry of Education, Science & Technological Development, Serbia 451-03-9/2021-14/200124, FSR Incoming Postdoctoral Fellowship Ministry of Education, Science and Technological Development, Serbia 451-03-9/2021-14/200124, University of Rijeka grant uniri-prirod-18-48, Croatian Science Foundation (HRZZ) IP-2016-06-9782, Villum Fonden 29405 DGA-FSE 2020-E2117R, European Regional Development Fund through the Center of Excellence (TK133) "The Dark Side of the Universe'' European Regional Development Fund (ESIF/ERDF), Ministry of Education, Youth & Sports - Czech Republic CoGraDS-CZ.02.1.01/0.0/0.0/15 003/0000437, Blavatnik grant, Basque Government IT-97916 Basque Foundation for Science (IKERBASQUE), European Space Agency C4000120711 4000132310, FNRS (Belgian Fund for Research), Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica (PAPIIT), Universidad Nacional Autonoma de Mexico TA100122, National University of La Plata X909 DICYT 042131GR, National Research, Development & Innovation Office (NRDIO) - Hungary 123996, FQXi, Swiss National Science Foundation (SNSF), European Commission 181461 199307, Netherlands Organization for Scientific Research (NWO) 680-91-119 15MV71, Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research (KAKENHI) 20H01899 20H05853 JP21F21789, Estonian Research Council PRG356, Julian Schwinger Foundation, Generalitat Valenciana Excellence PROMETEO-II/2017/033 PROMETEO/2018/165, Istituto Nazionale di Fisica Nucleare (INFN), European ITN project HIDDeN H2020-MSCA-ITN-2019//860881-HIDDeN, Swedish Research Council, European Commission 2016-05996 European Research Council (ERC) European Commission 668679, Advanced ERC grant TReX, Ministry of Education, Universities and Research (MIUR) 2017X7X85K, Fonds de la Recherche Scientifique - FNRS 4.4501.18, Ministry of Research, Innovation and Digitization - Romania PN19-030102-INCDFM PN-III-P4ID-PCE-2020-2374, United States Department of Energy (DOE) DE-SC0020262, Ministry of Science, ICT & Future Planning, Republic of Korea 075-15-2020-778, German Academic Scholarship Foundation German Research Foundation (DFG) 408049454 420243324 425333893 445990517 Germany's Excellence Strategy (EXC 2121 "Quantum Universe'') 390833306 390837967 Federal Ministry of Education & Research (BMBF) 05 A20GU2 05 A20PX1, Centro de Excelencia "Severo Ochoa'' SEV-2016-0588, CERCA program of the Generalitat de Catalunya, Agencia de Gestio D'Ajuts Universitaris de Recerca Agaur (AGAUR) Generalitat de Catalunya 2017-SGR-1469 2017-SGR-929 ICCUB CEX2019-000918-M, National Science Centre, Poland 2019/33/B/ST2/00050 2017/27/B/ST2/01902, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 306414/2020-1, Dicyt-USACH 041931MF, National Science Fund of Bulgaria KP-06-N 38/11 RCN ROMFORSK 302640, Comunidad de Madrid 2018-T1/TIC-10431 2019-T1/TIC-13177 S2018/NMT-4291, UK Research & Innovation (UKRI), Science & Technology Facilities Council (STFC) ST/T000759/1 ST/P000258/1 ST/T000732/1 ST/V005596/1, Portuguese Foundation for Science and Technology UIDB/00618/2020 UIDB/00777/2020 UIDP/00777/2020 CERN/FIS-PAR/0004/2019 PTDC/FIS-PAR/29436/2017 PTDC/FISPAR/31938/2017 PTDC/FIS-OUT/29048/2017 SFRH/BD/137127/2018, Centre National de la Recherche Scientifique (CNRS), LabEx UnivEarthS ANR-10-LABX-0023 ANR18-IDEX-0001, Junta de Andalucia European Commission A-FQM-053-UGR18, Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2021-03644, National Science Centre Poland Sonata Bis 2019/33/B/ST2/00050 DEC-2017/26/E/ST2/00763, Natural Sciences and Engineering Research Council of Canada (NSERC) DGIID-DGA 2015-E24/2, Spanish Research State Agency and Ministerio de Ciencia e Innovacion MCIN/AEI PID2019-104114RB-C32 PID2019-105544GB-I00 PID2019-105614GB-C21 PID2019106515GB-I00 PID2019-106802GB-I00 PID2019-107394GB-I00 PID2019-107844GB-C21 PID2019-107847RB-C41 MCIN/AEI PGC2018-095328-B-I00 PGC2018-094856-B-I00 PGC2018-096663-B-C41 PGC2018-096663-B-C44 PGC2018-094626-BC21 PGC2018-101858-B-I00 FPA2017-84543-P FPA2016-76005-C2-1-P, Spanish 'Ministerio de Universidades' BG20/00228 Spanish Government PID2020-115845GBI00 Generalitat de Catalunya Comunidad de Madrid S2018/NMT-4291 Spanish Government PID2019-105544GB-I00, Perimeter Institute for Theoretical Physics, Government of Canada through the Department of Innovation, Science and Economic Development, Province of Ontario through the Ministry of Colleges and Universities, Centre National de la Recherche Scientifique (CNRS), Netherlands Organization for Scientific Research (NWO), Fundamental Questions Institute (FQXi), European Cooperation in Science and Technology (COST) CA18108, Research Council of University of Guilan, Iniziativa Specifica TEONGRAV Iniziativa Specifica QGSKY Iniziativa Specifica QUAGRAP Iniziativa Specifica GeoSymQFT, the Spanish Research State Agency and Ministerio de Ciencia e Innovacion MCIN/AEI PID2020-115845GBI00 PID2019-108485GB-I00 PID2020-113334GB-I00 PID2020-113701GB-I00 PID2020-113775GB-I00 PID2020-118159GB-C41 PID2020-118159GA-C42 PRE2019-089024, Rothchild grant UID/MAT/00212/2020 FPU18/04571

Published
2022

183. Residual [beta] cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia

Author

Gubitosi-Klug, Rose A., Braffett, Barbara H., Hitt, Susan, Arends, Valerie, Uschner, Diane, Jones, Kimberly, Diminick, Lisa, Karger, Amy B., Paterson, Andrew D., Roshandel, Delnaz, Marcovina, Santica, Lachin, John M., Steffes, Michael, and Palmer, Jerry P.

Subjects
Polypeptides -- Measurement -- Health aspects, Type 1 diabetes -- Complications and side effects -- Physiological aspects, Pancreatic beta cells -- Physiological aspects -- Health aspects, Hypoglycemia -- Risk factors -- Prevention, Health care industry
Abstract

BACKGROUND. We investigated residual [beta] cell function in Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study participants with an average 35-year duration of type 1 diabetes mellitus (T1DM). METHODS. Serum C-peptide was measured during a 4-hour mixed-meal tolerance test. Associations with metabolic outcomes and complications were explored among nonresponders (all C-peptide values after meal 0.2), intermediate (>0.03 to RESULTS. Of the 944 participants, 117 (12.4%) were classified as responders. Residual C-peptide concentrations were associated with higher DCCT baseline concentrations of stimulated C-peptide (P value for trend = 0.0001). Residual C- peptide secretion was not associated with current or mean HbA1c, HLA high-risk haplotypes for T1DM, or the current presence of T1DM autoantibodies. The proportion of subjects with a history of severe hypoglycemia was lower with high (27%) and intermediate (48%) residual C-peptide concentrations than with low (74%) and no (70%) residual C-peptide concentrations (P value for trend = 0.0001). Responders and nonresponders demonstrated similar rates of advanced microvascular complications. CONCLUSION. [beta] Cell function can persist in long-duration T1DM. With a peak C-peptide concentration of >0.03 nmol/L, we observed clinically meaningful reductions in the prevalence of severe hypoglycemia. TRIAL REGISTRATION. ClinicalTrials.gov NCT00360815 and NCT00360893. FUNDING. Division of Diabetes Endocrinology and Metabolic Diseases of the National Institute of Diabetes and Digestive and Kidney Diseases (DP3-DK104438, U01 DK094176, and U01 DK094157)., Introduction Insulin secretion declines in most individuals with type 1 diabetes mellitus (T1DM) as duration of diabetes increases, yet residual insulin secretion, as detected by circulating C-peptide after a meal [...]

Published
2021
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184. On the Non-Existence of Perfect Codes in the Niederreiter-Rosenbloom-Tsfasman Metric

Author

Qureshi, Claudio, Gubitosi, Viviana, and Portela, Aldo

Abstract

In this paper we consider codes in $\mathbb F_{q}^{s\times r}$ with packing radius $R$ regarding the NRT-metric (i.e. when the underlying poset is a disjoint union of $s$ chains with the same length $r$ ) and we establish necessary condition on the parameters $s,r$ and $R$ for the existence of perfect codes. More explicitly, for $r,s\geq 2$ and $R\geq 1$ we prove that if there is a non-trivial perfect code then $(r+1)(R+1)\leq rs$ . We also establish a correspondence between perfect codes with $r > R$ and those with $r=R$ . Using this correspondence we prove the non-existence of non-trivial perfect codes in the cases $s\leq R+2$ and $s=3$ over non-binary alphabet.

Published
2024
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190. Obesity in Youth with Type 1 Diabetes in Germany, Austria, and the United States

Author

Willi, Steven, Lipman, Terri, Calvano, Tammy, Kucheruk, Olena, Minnock, Pantea, Nguyen, Chau, Klingensmith, Georgeanna, Banion, Carolyn, Barker, Jennifer, Cain, Cindy, Chase, Peter, Hoops, Sandy, Kelsy, Megan, Maahs, David, Mowry, Cathy, Nadeau, Kristen, Raymond, Jennifer, Rewers, Marian, Rewers, Arleta, Slover, Robert, Steck, Andrea, Wadwa, Paul, Walravens, Philippe, Zeitler, Philip, Haro, Heidi, Manseau, Katherine, Weinstock, Ruth, Izquierdo, Roberto, Sheikh, Umair, Conboy, Patricia, Bulger, Jane, Bzdick, Suzan, Goland, Robin, Gandica, Rachelle, Weiner, Lindsay, Cook, Steve, Greenberg, Ellen, Kohm, Kevin, Pollack, Sarah, Lee, Joyce, Gregg, Brigid, Tan, Meng, Burgh, Kimberly, Eason, Ashley, Garg, Satish, Michels, Aaron, Myers, Lisa, DiMeglio, Linda, Hannon, Tamara, Orr, Donald, Cruz, Christy, Woerner, Stephanie, Wolfsdorf, Joseph, Quinn, Maryanne, Tawa, Olivia, Ahmann, Andrew, Castle, Jessica, Joarder, Farahnaz, Bogan, Chris, Cady, Nancy, Cox, Jennifer, Pitts, Amy, Fitch, Rebecca, White, Brad, Wollam, Bethany, Bode, Bruce, Lindmark, Katie, Hosey, RaShonda, Bethin, Kathleen, Quattrin, Teresa, Ecker, Michelle, Wood, Jamie, Chao, Lily, Cheung, Clement, Fisher, Lynda, Jeandron, Debra, Kaufman, Francine, Kim, Mimi, Miyazaki, Brian, Monzavi, Roshanak, Patel, Payal, Pitukcheewanont, Pisit, Sandstrom, Anna, Cohen, Marisa, Ichihara, Brian, Lipton, Megan, Cemeroglu, Ayse, Appiagyei-Dankah, Yaw, Daniel, Maala, Postellon, Daniel, Racine, Michael, Wood, Michael, Kleis, Lora, Hirsch, Irl, DeSantis, Anthony, Dugdale, D.C., Failor, R. Alan, Gilliam, Lisa, Greenbaum, Carla, Janci, Mary, Odegard, Peggy, Trence, Dace, Wisse, Brent, Batts, Emily, Dove, Angela, Hefty, Deborah, Khakpour, Dori, Klein, Jani, Kuhns, Kristen, McCulloch-Olson, Marli, Peterson, Christina, Ramey, Mary, Marie, Marissa St., Thomson, Pam, Webber, Christine, Liljenquist, David, Sulik, Mark, Vance, Carl, Coughenour, Tiffany, Brown, Chris, Halford, Jean, Prudent, Andrea, Rigby, Shanda, Robison, Brandon, Starkman, Harold, Berry, Tymara, Cerame, Barbara, Chin, Daisy, Ebner-Lyon, Laurie, Guevarra, Frances, Sabanosh, Kristen, Silverman, Lawrence, Wagner, Christine, Fox, Marie, Buckingham, Bruce, Shah, Avni, Caswell, Kimberly, Harris, Breanne, Bergenstal, Richard, Criego, Amy, Damberg, Greg, Matfin, Glenn, Powers, Margaret, Tridgell, David, Burt, Cassie, Olson, Beth, Thomas, LeeAnn, Mehta, Sanjeev, Katz, Michelle, Laffel, Lori, Hathway, Joanne, Phillips, Roxanne, Cengiz, Eda, Tamborlane, William, Cappiello, Darryll, Steffen, Amy, Zgorski, Melinda, Peters, Anne, Ruelas, Valerie, Benjamin, Robert, Adkins, Deanna, Cuffee, Juanita, Spruill, Amber, Aleppo-Kacmarek, Grazia, Derby, Teresa, Massaro, Elaine, Webb, Kimberly, Burt Solorzano, Christine, DeBoer, Mark, Madison, Helen, McGill, Janet, Buechler, Lori, Clifton, Mary Jane, Hurst, Stacy, Kissel, Sarah, Recklein, Carol, Tsalikian, Eva, Tansey, Michael, Cabbage, Joanne, Coffey, Julie, Salamati, Sarah, Clements, Mark, Raman, Sripriya, Turpin, Angela, Bedard, Jennifer, Cohoon, Cyndy, Elrod, Aliza, Fridlington, Amanda, Hester, Lois, Kruger, Davida, Schatz, Desmond, Clare-Salzler, Michael, Cusi, Kenneth, Digman, Colleen, Fudge, Becky, Haller, Mike, Meehan, Collette, Rohrs, Henry, Silverstein, Janet, Wagh, Sujata, Cintron, Miriam, Sheehan, Eleni, Thomas, Jamie, Daniels, Mark, Clark, Susan, Flannery, Timothy, Forghani, Nikta, Naidu, Ajanta, Reh, Christina, Scoggin, Peggy, Trinh, Lien, Ayala, Natalie, Quintana, Rebeca, Speer, Heather, Zipf, William, Seiple, Diane, Kittelsrud, Julie, Gupta, Ashutosh, Peterson, Vikki, Stoker, Ashley, Gottschalk, Michael, Hashiguchi, Marla, Smith, Katheryn, Rodriguez, Henry, Bobik, Craig, Henson, Danielle, Simmons, Jill, Potter, Amy, Black, Margo, Brendle, Faith, Gubitosi-Klug, Rose, Kaminski, Beth, Bergant, Susan, Campbell, Wendy, Tasi, Catherine, Copeland, Kenneth, Beck, Joni, Less, Joane, Schanuel, Jill, Tolbert, Jennifer, Adi, Saleh, Gerard-Gonzalez, Andrea, Gitelman, Stephen, Chettout, Nassim, Torok, Christine, Pihoker, Catherine, Yi-Frazier, Joyce, Kearns, Susan, Libman, Ingrid, Bills, Vicky, Diaz, Ana, Duke, Julie, Nathan, Brandon, Moran, Antoinette, Bellin, Melena, Beasley, Shannon, Kogler, Anne, Leschyshyn, Janice, Schmid, Kara, Street, Anne, Nelson, Bryce, Frost, Carrie, Reifeis, Erin, Haymond, Morey, Bacha, Fida, Caldas-Vasquez, Maria, Klinepeter, Sara, Redondo, Maria, Berlanga, Rosa, Falk, Teresa, Garnes, Elizabeth, Gonzalez, Janette, Martinez, Cecilia, Pontifes, Mariam, Yulatic, Ronald, Arnold, Kathleen, Evans, Traci, Sellers, Sharon, Raman, Vandana, Foster, Carol, Murray, Mary, Brown, Trina, Slater, Hillarie, Wheeler, Karen, Harlan, David, Lee, Mary, Lock, John-Paul, Hartigan, Celia, Hubacz, Lisa, Buse, John, Calikoglu, Ali, Largay, Joseph, Young, Laura, Brown, Helen, Duncan, Vinnie, Duclos, Michelle, Tricome, Julie, Brandenburg, Verdayne, Blehm, Julie, Hallanger-Johnson, Julie, Hanson, Dawn, Miller, Corliss, Weiss, Jennifer, Hoffman, Robert, Chaudhari, Monika, Repaske, David, Gilson, Elizabeth, Haines, Jesse, Rudolph, Justen, McClave, Charles, Biersdorf, Doris, Tello, Anthony, Amundson, Donna, Ward, Rhonda, Rickels, Michael, Dalton-Bakes, Cornelia, Markman, Eileen, Peleckis, Amy, Rosenfeld, Nora, Dolan, Lawrence, Corathers, Sarah, Kichler, Jessica, Baugh, Holly, Standiford, Debbie, Hassing, Jeanne, Jones, Jennifer, Willis, Stephen, Wysham, Carol, Davis, Lisa, Blackman, Scott, Abel, Kimber-Lee, Clark, Loretta, Jonas, Andrea, Kagan, Ellie, Sosenko, Jay, Blashke, Carlos, Matheson, Della, Edelen, Rachel, Repas, Thomas, Baldwin, Denise, Borgwardt, Trista, Conroy, Christina, DeGrote, Kelly, Marchiando, Rod, Wasson, Michelle, Fox, Larry, Mauras, Nelly, Damaso, Ligeia, Englert, Kim, Hamaty, Marwan, Kennedy, Laurence, Schweiger, Michelle, Konstantinopoulos, Pantelis, Mawhorter, Carolyn, Orasko, Amy, Rose, Denise, Deeb, Larry, Rohrbacher, Kim, Schroeder, Leroy, Roark, Amanda, Ali, Omar, Kramer, Joanna, Whitson-Jones, Donna, Gassner, Heidi, Kollipara, Sobha, Harwood, Katerina, Prasad, Vijaya, Brault, Judy, DuBose, Stephanie N., Hermann, Julia M., Tamborlane, William V., Beck, Roy W., Dost, Axel, DiMeglio, Linda A., Schwab, Karl Otfried, Holl, Reinhard W., Hofer, Sabine E., and Maahs, David M.

Published
2015
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192. Risk of Foot Ulcer and Lower-Extremity Amputation Among Participants in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

Author

Edward J. Boyko, Leila R. Zelnick, Barbara H. Braffett, Rodica Pop-Busui, Catherine C. Cowie, Gayle M. Lorenzi, Rose Gubitosi-Klug, Bernard Zinman, and Ian H. de Boer

Subjects
Blood Glucose, Glycated Hemoglobin, Advanced and Specialized Nursing, Diabetes Mellitus, Type 1, Risk Factors, Endocrinology, Diabetes and Metabolism, Internal Medicine, Humans, Extremities, Epidemiology/Health Services Research, Amputation, Surgical, Diabetic Foot
Abstract

OBJECTIVE Intensive glycemic control reduces the risk of kidney, retinal, and neurologic complications in type 1 diabetes (T1D), but whether it reduces the risk of lower-extremity complications is unknown. We examined whether former intensive versus conventional glycemic control among Diabetes Control and Complications Trial (DCCT) participants with T1D reduced the long-term risk of diabetic foot ulcers (DFUs) and lower-extremity amputations (LEAs) in the subsequent Epidemiology of Diabetes Interventions and Complications (EDIC) study. RESEARCH DESIGN AND METHODS DCCT participants (n = 1,441) completed 6.5 years on average of intensive versus conventional diabetes treatment, after which 1,408 were enrolled in EDIC and followed annually over 23 years for DFU and LEA occurrences by physical examination. Multivariable Cox proportional hazard regression models estimated associations of DCCT treatment assignment and time-updated exposures with DFU or LEA. RESULTS Intensive versus conventional glycemic control was associated with a significant risk reduction for all DFUs (hazard ratio 0.77 [95% CI 0.60, 0.97]) and a similar magnitude but nonsignificant risk reduction for first-recorded DFUs (0.78 [0.59, 1.03]) and first LEAs (0.70 [0.36, 1.36]). In adjusted Cox models, clinical neuropathy, lower sural nerve conduction velocity, and cardiovascular autonomic neuropathy were associated with higher DFU risk; estimated glomerular filtration rate CONCLUSIONS Early intensive glycemic control decreases long-term DFU risk, the most important antecedent in the causal pathway to LEA.

Published
2022

194. Relationships Between the Cumulative Incidences of Long-term Complications in Type 1 Diabetes: The DCCT/EDIC Study

Author

Bebu, Ionut, primary, Braffett, Barbara H., additional, de Boer, Ian H., additional, Aiello, Lloyd P., additional, Bantle, John P., additional, Lorenzi, Gayle M., additional, Herman, William H., additional, Gubitosi-Klug, Rose A., additional, Perkins, Bruce A., additional, Lachin, John M., additional, and Molitch, Mark E., additional

Published
2022
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195. Relationships between the Cumulative Incidences of Long-Term Complications in Type 1 Diabetes Mellitus: the DCCT/EDIC Study

Author

Bebu, Ionut, primary, Braffett, Barbara H., primary, Boer, Ian H. de, primary, Aiello, Lloyd P., primary, Bantle, John P., primary, Lorenzi, Gayle M., primary, Herman, William H., primary, Gubitosi-Klug, Rose A., primary, Perkins, Bruce A., primary, Lachin, John M., primary, Molitch, Mark E., primary, and Group, DCCT/EDIC Research, primary

Published
2022
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197. Relationships between the Cumulative Incidences of Long-Term Complications in Type 1 Diabetes Mellitus: the DCCT/EDIC Study

Author

DCCT/EDIC Research Group, Mark E. Molitch, John M. Lachin, Bruce A. Perkins, Rose A. Gubitosi-Klug, William H. Herman, Gayle M. Lorenzi, John P. Bantle, Lloyd P. Aiello, Ian H. de Boer, Barbara H. Braffett, and Ionut Bebu

Abstract

Objective To describe the relationships between the cumulative incidences of long-term complications in individuals with type 1 diabetes (T1D), and assess whether observed associations are independent of age, duration of diabetes, and glycemic levels. Methods Proliferative diabetic retinopathy (PDR), clinically significant macular edema (CSME), reduced eGFR, amputations, cardiovascular disease (CVD) and mortality were assessed in DCCT/EDIC over ~30 years. Results The cumulative incidence of complications ranged from 3% (amputations) to 37% (CSME). There were large differences in the cumulative incidence of: PDR between participants with versus without prior CSME (66% vs. 15%), reduced eGFR (59% vs. 29%) and amputation (68% vs. 32%); reduced eGFR with/without prior PDR (25% vs. 9%), amputation (48% vs. 13%), and CVD (30% vs. 11%); CVD with/without prior reduced eGFR (37% vs. 14%) and amputation (50% vs. 16%); and mortality with/without prior reduced eGFR (22% vs. 9%), amputation (35% vs. 8%) and CVD (25% vs. 8%). Adjusted for age, duration of T1D, and mean updated HbA1c, the complications and associations with higher risk included: PDR with CSME (HR=1.88, 95%CI:[1.42,2.50]), reduced eGFR (HR=1.41, [1.01,1.97]), and CVD (HR=1.43, [1.06,1.92]); CSME with higher risk of PDR (HR=3.94, [3.18,4.89]), reduced eGFR (HR=1.49, [1.10,2.01]), and CVD (HR=1.35, [1.03,1.78]); reduced eGFR with higher risk of CVD (HR=2.09, [1.44,3.03]) and death (HR=3.40, [2.35,4.92]); amputation(s) with death (HR=2.97, [1.70,2.90]); and CVD with reduced eGFR (HR=1.59, [1.08,2.34]) and death (HR=1.95, [1.32,2.90]). Conclusions Long term micro- and macrovascular complications and mortality are highly correlated. Age, diabetes duration, and glycemic levels do not completely explain these associations.

Published
2022

200. The power of TOPMed imputation for the discovery of Latino enriched rare variants associated with type 2 diabetes

Author

Alicia Huerta-Chagoya, Philip Schroeder, Ravi Mandla, Aaron J. Deutsch, Wanying Zhu, Lauren Petty, Xiaoyan Yi, Joanne B. Cole, Miriam S. Udler, Peter Dornbos, Bianca Porneala, Daniel DiCorpo, Ching-Ti Liu, Josephine H. Li, Lukasz Szczerbiński, Varinderpal Kaur, Joohyun Kim, Yingchang Lu, Alicia Martin, Decio L. Eizirik, Piero Marchetti, Lorella Marselli, Ling Chen, Shylaja Srinivasan, Jennifer Todd, Jason Flannick, Rose Gubitosi-Klug, Lynne Levitsky, Rachana Shah, Megan Kelsey, Brian Burke, Dana M. Dabelea, Jasmin Divers, Santica Marcovina, Lauren Stalbow, Ruth J.F. Loos, Burcu F. Darst, Charles Kooperberg, Laura M. Raffield, Christopher Haiman, Quan Sun, Joseph B. McCormick, Susan P. Fisher-Hoch, Maria L. Ordoñez, James Meigs, Leslie J. Baier, Clicerio González-Villalpando, Maria Elena González-Villalpando, Lorena Orozco, Andrés Moreno, Carlos A. Aguilar-Salinas, Teresa Tusié, Josée Dupuis, Maggie C.Y. Ng, Alisa Manning, Heather M. Highland, Miriam Cnop, Robert Hanson, Jennifer Below, Jose C. Florez, Aaron Leong, and Josep M. Mercader

Abstract

HypothesisThe prevalence of type 2 diabetes is higher in Latino populations compared with other major ancestry groups. Not only has the Latino population been systematically underrepresented in large-scale genetic analyses, but previous studies relied on the imputation of ungenotyped variants based on the 1000 Genomes (1000G) imputation reference panel, which results in suboptimal capture of low-frequency or Latino-enriched variants. The NHLBI Trans-Omics for Precision Medicine (TOPMed) reference panel represents a unique opportunity to analyze rare genetic variations in the Latino population.MethodsWe evaluate the TOPMed imputation performance using genotyping array and whole-exome sequence data in 6 Latino cohorts. To evaluate the ability of TOPMed imputation of increasing the identified loci, we performed a Latino type 2 diabetes GWAS meta-analysis in 8,150 type 2 diabetes cases and 10,735 controls and replicated the results in 6 additional cohorts including whole-genome sequence data from the All of Us cohort.ResultsWe show that, compared to imputation with 1000G, the TOPMed panel improves the identification of rare and low-frequency variants. We identified 26 distinct signals including a novel genome-wide significant variant (minor allele frequency 1.6%, OR=2.0, P=3.4×10−9) near ORC5. A Latino-tailored polygenic score constructed from our data and GWAS data from East Asian and European populations improves the prediction accuracy in a Latino target dataset, explaining up to 7.6% of the type 2 diabetes risk variance.ConclusionsOur results demonstrate the utility of TOPMed imputation for identifying low-frequency variation in understudied populations, leading to the discovery of novel disease associations and the improvement of polygenic scores.

Published
2022

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