To investigate the relationship between serum CXC chemokine ligand 1 (CXCL1), CXC chemokine ligand 10 (CXCL10) and nerve injury index and prognosis after minimally invasive puncture and drainage in patients with hypertensive basal ganglia hemorrhage (HBGH). 162 patients with HBGH who were underwent minimally invasive puncture and drainage in the East ward of Liaocheng People's Hospital from February 2020 to April 2023 were selected as study group, and 110 healthy volunteers who were underwent physical examination in our hospital during the same period were selected as control group. The levels of serum CXCL1, CXCL10 and nerve injury indexes [neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP) and S100茁 protein] were detected and compared between two groups. The correlation between serum CXCL1, CXCL10 and nerve injury indexes were analyzed by Pearson test. All patients were followed up for 3 months, and the prognosis of the patients was evaluated according to the modified Rankin scale (mRS), patients were divided into good prognosis group and poor prognosis group. The prognostic factors of patients with HBGH after minimally invasive puncture and drainage was analyzed by multivariate Logistic regression model. The levels of serum CXCL1 and CXCL10 in study group were higher than those in control group (P<0.05). The levels of serum NSE, GFAP and S100茁 protein in study group were higher than those in control group(P<0.05). Pearson test analysis showed that, serum CXCL1 and CX-CL10 were positively correlated with NSE, GFAP and S100β protein (P<0.05). Univariate analysis showed that, poor prognosis was associated with age, triglyceride (TG), low-density lipoprotein (LDL), prothrombin time (PT), C-reactive protein (CRP), hematoma breaking into the ventricle, hematoma volume, hematoma clearance rate within 24 hours after operation, number of urokinase flushing, recurrence of postoperative intracranial hemorrhage, CXCL1 and CXCL10 (P<0.05). Multivariate Logistic regression analysis showed that, older age, higher LDL, larger hematoma volume, lower hematoma clearance rate within 24 hours after operation, more times of urokinase flushing, higher CXCL1 and higher CXCL10 were risk factors for poor prognosis of HBGH patients after minimally invasive puncture and drainage (P<0.05). Elevate serum CXCL1 and CXCL10 levels in patients with HBGH may lead to nerve injury and poor prognosis. Age, LDL, hematoma volume, hematoma clearance rate within 24 hours after operation, number of urokinase flushes, CXCL1 and CXCL10 are risk factors for poor prognosis in patients with HBGH, which deserves attention. [ABSTRACT FROM AUTHOR]