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The paper considers the hydrogen diffusion into metals from their external environment. In order to properly describe a time-stable boundary layer (experimentally observed) with a hydrogen concentration being tens of times higher than that inside the body, the previously obtained hydrogen diffusion equation has been modified. This equation obtained from the first principles and taking into account the influence of the stress-strain state of solid on the transport process of the gas component, was supplemented with a stock term describing the diffusion with trapping modes. This modification was carried out in two ways: using the classical McNabb model and using the tensor of damageability. The boundary-value problem was solved for both approaches. The solution results were compared with published experimental data.

Several solid lesions can be found within the pancreas mainly arising from the exocrine and endocrine pancreatic tissue. Among all pancreatic malignancies, the most common subtype is pancreatic ductal adenocarcinoma (PDAC), to a point that pancreatic cancer and PDAC are used interchangeably. But, in addition to PDAC, and to the other most common and well-known solid lesions, either related to benign conditions, such as pancreatitis, or not so benign, such as pancreatic neuroendocrine neoplasms (pNENs), there are solid pancreatic lesions considered rare due to their low incidence. These lesions may originate from a cell line with a differentiation other than exocrine/endocrine, such as from the nerve sheath as for pancreatic schwannoma or from mesenchymal cells as for solitary fibrous tumour. These rare solid pancreatic lesions may show a behaviour that ranges in a benign to highly aggressive malignant spectrum. This review includes cases of an intrapancreatic accessory spleen, pancreatic tuberculosis, solid serous cystadenoma, solid pseudopapillary tumour, pancreatic schwannoma, purely intraductal neuroendocrine tumour, pancreatic fibrous solitary tumour, acinar cell carcinoma, undifferentiated carcinoma with osteoclastic-like giant cells, adenosquamous carcinoma, colloid carcinoma of the pancreas, primary leiomyosarcoma of the pancreas, primary and secondary pancreatic lymphoma and metastases within the pancreas. Therefore, it is important to determine the correct diagnosis to ensure optimal patient management. Because of their rarity, their existence is less well known and, when depicted, in most cases incidentally, the correct diagnosis remains challenging. However, there are some typical imaging features present on cross-sectional imaging modalities that, taken into account with the clinical and biological context, contribute substantially to achieve the correct diagnosis.

The Solid specification aims to empower data subjects by giving them direct access control over their data across multiple applications. As governments are manifesting their interest in this framework for citizen empowerment and e-government services, security and privacy represent pivotal issues to be addressed. By analysing the relevant legislation, with an emphasis on GDPR and officially approved documents such as codes of conduct and relevant security ISO standards, we formulate the primary security and privacy requirements for such a framework. The legislation places some obligations on pod providers, much like cloud services. However, what is more interesting is that Solid has the potential to support GDPR compliance of Solid apps and data users that connect, via the protocol, to Solid pods containing personal data. A Solid-based healthcare use case is illustrated where identifying such controllers responsible for apps and data users is essential for the system to be deployed. Furthermore, we survey the current Solid protocol specifications regarding how they cover the highlighted requirements, and draw attention to potential gaps between the specifications and requirements. We also point out the contribution of recent academic work presenting novel approaches to increase the security and privacy degree provided by the Solid project. This paper has a twofold contribution to improve user awareness of how Solid can help protect their data and to present possible future research lines on Solid security and privacy enhancements.

The number of artificial objects in space increases due to past and present space activities. To analyse the quantity of the small (diameter >100 μm up to cm) space debris and meteoroids, an innovative in-situ impact detection method has been developed at DLR (German Aerospace Center) in Bremen, Germany. The method Solar panel-based Impact Detector "SOLID" uses solar panels for impact detection. Since solar panels provide large detection areas and exist on nearly all satellites, this method enables for the collection of large amounts of data in different orbits. An impacting object generates a permanent damage on a panel. The damage can be determined during analysis scan as well as confirmed or refuted in the frame of subsequent scans of the panels. Those properties of the sensor system can significantly improve the amount as well as the quality of measurement data to be used for environmental model validation. The SOLID method was successfully verified on ground by Hypervelocity Impact (HVI) tests at Fraunhofer EMI, Freiburg, Germany. The ability of the detection method SOLID for impact detection of space debris and meteoroids was clearly demonstrated on ground. Since July 2017, the SOLID sensor system is placed in a 600 km Sun-synchronous orbit on the microsatellite mission TechnoSat of Technische Universität Berlin (TUB). Four solar panels equipped with SOLID technology are installed on the satellite for in-orbit testing and environmental exploration. The total detection area of all panels is about 0.0755 m2. The system was designed to detect space debris or meteoroid objects with a diameter larger than 100 μm. In total 15,570,047 scans were performed over the four years in space. By means of measurement data changes were identified on one panel. However, so far, the telemetry data shows no clear evidence for an impact. • Development of a large area in-situ debris and meteoroid detector SOLID. • In orbit testing of in-situ debris and meteoroid detector SOLID. • Interpretation of in-situ measurement data. • Estimation of expected impacts using environmental model MASTER 8. • Environmental models validation by utilization of measured data. [ABSTRACT FROM AUTHOR]

[Display omitted] • Inexpensive, small, and easy-to-handle solid-addition funnel. • Enables solid addition under inert atmosphere. • Alternative to glovebox use in many applications. • Good addition efficiency (ca. 99% can be introduced). • Improved our double glycosylation yield (from trace to 64%). Even though catalyst loading is one of the first crucial steps in organic and inorganic catalytic reactions, it has not been frequently discussed or improved to date. In particular, when a solid catalyst is added to an oxygen- and moisture-sensitive reaction mixture, a carefully tuned process to ensure an inert atmosphere (under nitrogen or argon) is required. Although gloveboxes are nowadays considered to be a universal solution, it is still associated with unsolved problems, such as high cost, high space consumption, difficult temperature control, and handling difficulties on account of the gloves. Herein, we report a recently developed simple apparatus that enables the addition of a solid without opening the reaction vessel. This solid-addition funnel drastically improved the yield (from trace to 64%) and the reproducibility of our original glycosylation reaction. [ABSTRACT FROM AUTHOR]

• Impact of micropapillary and/or solid (MPSOL) on survival of stage I lung cancer. • Effect of completeness of lymph node assessment (LNA) for MPSOL + patients. • MPSOL + patients with complete LNA had better survival than those with incomplete LNA. • No difference in survival of MPSOL + patients between lobectomy and sublobar resection. • In patient with MPSOL+, complete LNA rather than the extent of surgery affect survival. We aimed to evaluate the impact of micropapillary and/or solid (MPSOL) components on survival and recurrence of patients with resected stage I lung adenocarcinoma (LUAD) according to the extent of surgery and completeness of lymph node assessment (LNA). We retrospectively reviewed 1886 consecutive patients who underwent surgical resection for pathologic stage I LUAD between 2009 and 2014. The patients were classified by the presence (≥1%) of MPSOL into the MPSOL(+) (n = 489) and MPSOL(−) (n = 1397) group.We analyzed the outcomes according to the extent of surgery (sublobar resection [SR] vs. lobectomy) and the LNA (complete vs. incomplete). Complete LNA was defined as systematic LN dissection according to European Society of Thoracic Surgeons guideline. In the MPSOL(+) patients, there was no significant difference in adjusted overall survival (OS), recurrence-free survival (RFS), and recurrence pattern between the lobectomy and SR group. Of note, patients with complete LNA had higher adjusted OS and RFS than those with incomplete LNA (aOS, 86.3% vs. 78%, p = 0.002; aRFS, 70% vs 63.1%, p = 0.06). In the MPSOL(−) patients, adjusted RFS of the SR group was better than the lobectomy group (95% vs. 90.5%, p = 0.021), although there was no difference in survival regarding to the LNA. Complete LNA was a favorable prognostic factor for RFS in the MPSOL(+) patients (HR = 0.463, 95% CI: 0.227–0.944, p = 0.034). In MPSOL(+) patients, complete LN assessment affects the OS and RFS rather than the extent of lung resection. In patients with solid tumor or tumor>2 cm, a complete LN assessment would be required, even if sublobar resection is unavoidable. [ABSTRACT FROM AUTHOR]

Next-generation sequencing (NGS) is a new technology used to detect the sequence of DNA and RNA and to detect mutations or variations of significance. NGS generates large quantities of sequence data within a short time duration. The various types of sequencing includes Sanger Sequencing, Pyrosequencing, Sequencing by Synthesis (Illumina), Ligation (SoLID), Single molecule Fluorescent Sequencing (Helicos), Single molecule Real time Sequencing (Pacbio), Semiconductor sequencing (Ion torrent technology), Nanopore sequencing and fourth generation sequencing. These methods of sequencing have been modified and improved over the years such that it has become cost effective and accessible to diagnostic laboratories. Management of Outbreaks, rapid identification of bacteria, molecular case finding, taxonomy, detection of the zoonotic agents and guiding prevention strategies in HIV outbreaks are just a few of the many applications of Next Generation sequencing in clinical microbiology. [ABSTRACT FROM AUTHOR]

Mass lesions in the retroperitoneal space may be primary or secondary. Primary retroperitoneal mass lesions are relatively uncommon as compared to pathology that arises secondarily from retroperitoneal organs. These may be solid or cystic lesions. The overlapping imaging features of various solid primary retroperitoneal tumors make the diagnosis difficult, and hence, histopathology remains the mainstay of diagnosis. This paper provides a brief review of the anatomy of the retroperitoneal space and provides an algorithmic approach based on cross-sectional imaging techniques to narrow down the differential diagnosis of solid primary retroperitoneal masses encountered in the adult population. [ABSTRACT FROM AUTHOR]

A pilot plant is the pre-commercial production system which includes new production technology and produces small volumes of new technology based products. Scale up is the process of increasing the batch size or a procedure for applying the same process to different output volumes. Process scale up for a technology is one the most common reasons to build a pilot plant. It is a connection between Research and Development (R and D) Industry. It is a Hybrid development facility and Manufacturing unit. Even though commercialization is the primary motivation for pilot plant projects, there can be multiple, complex objectives that will vary by project organization and goals. It is a place where the 5M'S like Money, Material, Man, Method and Machine are brought together for the manufacturing of the products. In pilot plant before investing a large sum of money on a production unit it is a small preliminary lab scale formula to be carried out on a model of proposed plant. Pilot plant scale up gives information about examination of formula can be done, review of range of relevant processing equipment, the specification of the raw materials can be understood, we can know the production rate, the physical space needed can be checked. It can store appropriate records and reports for analysis to support GMP process. Pilot plant scale up considerations for solids, liquids, semisolids is discussed here. The main objective of pilot plant is "Find mistakes on a small scale and make profit on large scale". [ABSTRACT FROM AUTHOR]

Colloidal-chemical transformations accompanying the thermal degradation of a homogeneous aqueous solution of nickel(II) ammoniac complexes are investigated by thermodynamic and kinetic methods. A competitive growth mechanism of β-Ni(OH)2 nano- and microcrystals in the solution bulk and on the solution–solid interface is proved. The weight growth rate for each of the kinetic routes is controlled by the kinetics of the first-order homogeneous reaction of degradation. The reason for the competitive weight gain of the sol and β-Ni(OH)2 film lies in the different activation energies for conversion to sol microcrystals (131.0 ± 27.0 kJ/mol) and to the film (94.0 ± 24.0 kJ/mol). This gives rise to the existence of two different temperature areas where sol or film growth is preferable. At 70–75°C, the sol and film growth rates are equal. An interpretation of the temperature-dependent colloidal growth mechanism of Ni(OH)2 crystals is proposed. The influence of the morphology and thickness of β-Ni(OH)2 films on their optical band gap width, photocatalytic and electrical activities is determined. [ABSTRACT FROM AUTHOR]

The effect of mechanical action on the mixing and whipping of a mixture of components contributes to the establishment of a three-dimensional sponge-mesh continuous structure of the gluten framework, as it determines the elastic and elastic properties of the medium and is relevant in the dispersion of gas in a liquid. The purpose of the work was to establish the relationship between the gas retention capacity of the medium and the energy consumed for the hydration of the components. The experiments performed the task of determining the gas retention capacity of the medium with variable parameters of the height of the liquid phase from the intensity of mixing, the time of the transient processes of the formation of the full volume of the gas-liquid medium, the time of the transient process of the dispersed gas phase. The difference in levels before the gas phase generation and the stirring mode determines the value of gas retention capacity. Therefore, it was concluded that it is expedient to completely destabilise the steady-state regimes by changing the modes of action of the working body in the flow system. An additional impact on the system is the change of hydrodynamic regimes due to the unstable dynamics of the dispersed gas phase generation. The generation of this phase means the presence of energy costs for the interfacial surface establishment, which must be considered in the overall energy balance. In addition, a part of the gas phase, which existed and continues to exist in the new regime after mixing, enters the transient regime. Therefore, the most effective mixing occurs in case of compliance with the shifted mode of dosing components in a suspended state and the mechanical impact of the working body. Considering the tasks and conditions for mixing the dough, the requirements for the design of the mixer are determined, and it is established that the supply of components should last at least 45 seconds. During this period, there is hydration and a reduction in energy consumption. Such an approach intensifies mass transfer and biochemical processes under conditions of thermodynamic equilibrium with appropriate desorption bonds of the dissolved part of the gas phase and liquid, which covers a new method of mixing and allows further use in the design calculations of working chambers

Farmers in oil palm plantation areas in Seluma Regency have utilized the solid potential of palm oil waste as a source of beef cattle feed. Tunas Harapan Livestock Group, Sumber Arum Village, Sukaraja District, started using solid feed in 2009 to 2017, but now many farmers are no longer using it. This study aims to identify the inhibiting factors for solid use in Tunas Harapan Livestock Group. The study was conducted from July to August 2018. Data collection through in-depth interviews involved two key informants, namely the Head of the Farmer's Group and an agricultural extension worker, which was confirmed by interviews with 3 farmers and observations. The data collected is the result of the identification of technical, economic, and social factors related to the maintenance of beef cattle. The data were analyzed using the AHP (Analytical Hierarchy Process) method. The results showed that technical factors were the main obstacle to solid use with a value of 63.7%, followed by economic factors (25.8%) and social factors (10.5%). The reduction in the scale of livestock rearing from 4-5 to 1-2 is the dominant technical factor that hinders the sustainability of solid use in the field.

The paper presents an estimation of methane emission from deposited municipal solid waste in Germova landfill located in the Mitrovica Region for the years 2006–2019. Methane emission was calculated according to the methodology recommended by IPCC 2006, using default values. Within framework of the research, the following parameters were evaluated: population covered by the waste collection service in the region, amount of landfilled waste, landfill characteristics, and composition of landfilled waste and climate conditions of the region. Based on these parameters, the total amount of CH4 emitted from the landfill during 2006–2019 was estimated at 19.3 Gg or 485 Gg CO2 eq.

Future experiments at the Jefferson Lab 12 GeV upgrade, in particular, the Solenoidal Large Intensity Device (SoLID), aim at a very precise data set in the region where the partonic structure of the nucleon is dominated by the valence quarks. One of the main goals is to constrain the quark transversity distributions. We apply recent theoretical advances of the global QCD extraction of the transversity distributions to study the impact of future experimental data from the SoLID experiments. Especially, we develop a simple strategy based on the Hessian matrix analysis that allows one to estimate the uncertainties of the transversity quark distributions and their tensor charges extracted from SoLID data simulation. We find that the SoLID measurements with the proton and the effective neutron targets can improve the precision of the u- and d-quark transversity distributions up to one order of magnitude in the range 0.05

Future experiments at the Jefferson Lab 12 GeV upgrade, in particular, the Solenoidal Large Intensity Device (SoLID), aim at a very precise data set in the region where the partonic structure of the nucleon is dominated by the valence quarks. One of the main goals is to constrain the quark transversity distributions. We apply recent theoretical advances of the global QCD extraction of the transversity distributions to study the impact of future experimental data from the SoLID experiments. Especially, we develop a simple strategy based on the Hessian matrix analysis that allows one to estimate the uncertainties of the transversity quark distributions and their tensor charges extracted from SoLID data simulation. We find that the SoLID measurements with the proton and the effective neutron targets can improve the precision of the u- and d-quark transversity distributions up to one order of magnitude in the range 0.05

Xiaofei Yu,1,* Zhengwei Dong,2,* Wanying Wang,1 Shiqi Mao,1 Yingying Pan,1 Yiwei Liu,1 Shuo Yang,1 Bin Chen,1 Chunyan Wang,1 Xuefei Li,3 Chao Zhao,3 Keyi Jia,1 Chuchu Shao,1 Chunyan Wu,2 Shengxiang Ren,1 Caicun Zhou1 1Department of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 2Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 3Department of Lung Cancer and Immunology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shengxiang RenDepartment of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of ChinaTel +86-21-65115006Fax +86-21-65111298Email harry_ren@126.comChunyan WuDepartment of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, No. 507, Zheng Min Road, Shanghai, 200433, People’s Republic of ChinaFax +86-21-65111298Email wuchunyan581@163.comPurpose: High-grade patterns (micropapillary/solid/complex gland) are associated with a higher recurrence rate and shorter disease-free survival. Thus far, it remains unclear whether the efficacy of first-line anticancer therapy is different from that of the other adenocarcinoma subgroups for patients with high-grade patterns. The study aimed to investigate the association between an adenocarcinoma with high-grade patterns with the outcomes of first-line treatment in patients with lung cancer.Patients and Methods: Patients with a high-grade pattern adenocarcinoma (more than 20% of micropapillary/solid components/complex glandular patterns) were retrospectively analyzed between June 2015 and June 2017. Patients’ clinical characteristics and treatment outcomes were compared with those of the remaining control adenocarcinoma subgroups.Results: In total, 239 patients with adenocarcinoma, including 115 (48.1%) high-grade patterns and 124 (51.9%) control groups, were enrolled. Patients’ clinical characteristics such as age, sex, smoking status, and stage were similar between the two groups. Among them, 108 patients received first-line chemotherapy, and 131 received epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR-TKIs). In the chemotherapy group, adenocarcinoma of high-grade patterns had a significantly lower objective response rate (ORR; 15.6% vs 36.4%, P=0.045), shorter progression-free survival (PFS; median 4.1 vs 5.4 months, P=0.007) and overall survival (OS, median 19.6 vs 23.8 months, P=0.048) compared with the control group. As for these treated with EGFR-TKIs, a similar ORR (70.7% vs 72.1%, P=0.703), PFS (median 11.3 vs 13.9 months, P=0.065) and OS (median 34.1 vs 29.6%, p=0.575) were observed between these two groups.Conclusion: An adenocarcinoma with high-grade patterns is associated with inferior outcomes to first-line chemotherapy in relapsed lung cancer. Patients who received chemotherapy had a significantly shorter PFS and OS and lower ORR than control subjects, while there was no difference in the EGFR-TKI cohort. This study is the first to report the distribution of adenocarcinoma with high-grade patterns.Keywords: adenocarcinoma, micropapillary, solid, chemotherapy, EGFR-TKIs

In this study, the quality of wood fuel pellets, commercially available in the Greek market, was evaluated using the ISO 17225 Standard Requirement Thresholds as a benchmark. The examined quality criteria were calorific value, ash content, mechanical durability, bulk density and moisture content. The reliability of the information on packages was evaluated. Meanwhile, the potential correlation between the most crucial qualitative properties of pellets was investigated to elucidate their potential contribution to pellets' quality estimation. Most of the pellet brands showed low moisture and ash content and acceptable calorific values for residential use—although the quality of half of the pellet brands was found to be lower than that reported, mainly with regard to the mechanical durability and bulk density. The application of two different collection periods highlighted a stability in quality over time. Higher calorific value seemed to be provided by pellets which had low ash and low moisture content and were mechanically durable. As regards the specific samples, a dark colour and high roughness were correlated with lower fuel quality (impact of 56.2% and 43.6%, respectively). [ABSTRACT FROM AUTHOR]

Digestate is a residue of the anaerobic decomposition of organic waste for biogas extraction, but it can be reused as a source of nutrients. To examine the effect of digestate in kohlrabi production, field experiments were conducted during three seasons in two calendar years. The fertilization treatments included the application of solid digestate (two rates—DS1 and DS2), liquid digestate (two rates—DL1 and DL2), solid manure (two rates—MS1 and MS2), and mineral fertilizer (NPK) and were compared with a plot without fertilization (Ø). The results showed a significant increase in the yield with the use of solid and liquid digestate, as well as with NPK, in all growing seasons, while the microelement contents (Zn, Mn, and Cu) in the leaves were at optimum level. The applied treatments did not increase the plant-available nutrients (AL-P2O5, AL-K2O, Fe, Cu, and Zn) in the soil (except Mn). The application of DL2, MS1, and MS2 led to a higher Pb content in kohlrabi stems compared to the control, but the Pb content remained below the maximum permitted limit. Our research showed that digestate can be used as a valuable source of nutrients for kohlrabi production, with a low risk of soil and plant contamination by heavy metals. However, the control of soil, digestates, and manure quality is recommended. [ABSTRACT FROM AUTHOR]

The physical properties of crystals are determined by their chemical nature, the structure of both the entire volume and the surface layer. The surface of a metal, ionic or covalent crystal and semiconductor can be considered as a special state of matter with its own chemistry and physics. The interest in the problem of solid state surfaces, in the science of surface, in the physics of thin films is stimulated by advances in solid state physics, technical innovations, opportunities to create new film materials with unique properties, the challenges of modern technology, the requirements of technology to create devices for computing technology and microelectronics. In this work the processes of redistribution of infiltration atoms along the surface and bulk inter-nodes are considered, the equilibrium distribution of infiltrated atoms on the surface and in the crystal volume, as well as the effect of external pressure on the surface and bulk distribution of infiltration atoms, are studied. Knowledge of the processes of redistribution of infiltration atoms along the inter-nodules of a crystal and of the reasons causing them may allow the purposeful formation of these processes for the purpose of obtaining certain physical characteristics of materials. The kinetics of inter-nodal rearrangement of infiltration atoms has been studied for metals and ordering alloys of various structures [ABSTRACT FROM AUTHOR]

The results obtained in the experiments of the high-speed entry of the solids into water and experiments on crossing the flat air-plasticine interface by solids are compared with the properties of light, which are manifested under similar conditions. The shots have been fired along the normal and at an angle to the surface with single spherical bodies, lined up in single file or packed tightly in a thin wooden cup in layers of seven balls (one in the center and six around). This condition makes it possible to compare the phenomenon of rebound reflection, refraction, diffraction, interference. [ABSTRACT FROM AUTHOR]

Purpose: To compare the diagnostic accuracy and safety of computed tomography (CT)-guided core needle biopsy (CNB) between pulmonary ground-glass and solid nodules using propensity score matching (PSM) method and determine the relevant risk factors. Methods: This was a single-center retrospective cohort study using data from 665 patients who underwent CT-guided CNB of pulmonary nodules in our hospital between May 2019 and May 2021, including 39 ground-glass nodules (GGNs) and 626 solid nodules. We used a 1:4 PSM analysis to compared the diagnostic yields and complications rates of CT-guided CNB between 2 groups. Results: After PSM, 170 cases involved in the comparison (34 GGNs vs 136 solid nodules) were randomly matched (1:4) by patient demographics, clinical history, lesion characteristics, and procedure-related factors. There was no statistically significant difference in the diagnostic yields and complications rates between 2 groups. Significant pneumothorax incidence increase was noted at small lesion size, deep lesion location, and traversing interlobar fissure (P <.05). Post-biopsy hemorrhage was a protective factor for pneumothorax (P <.05). The size/proportion of consolidation of GGN did not influence the diagnostic accuracy and complication incidence (P >.05). Conclusions: The accuracy and safety of CT-guided CNB were comparable for ground-glass and solid nodules and the size/proportion of consolidation of GGN may be not a relevant risk factor. The biopsy should avoid traversing interlobar fissure as far as possible. Smaller lesion size and deeper lesion location may lead to higher pneumothorax rate and post-biopsy hemorrhage may be a protective factor for pneumothorax. [ABSTRACT FROM AUTHOR]

In our discussions around the theme of solid fluids, we often resort to everyday words, many of them of ancient derivation and rich in association. We have decided to make a list of some of the words that come up most often – barring those that already figure as the principal characters of individual contributions – and to distribute among ourselves the task of writing a sort of mini-biography for each. The resulting lexicon with 19 entries, ranging from 'cloud' and 'concrete' to 'wave' and 'wood', serves as a conclusion to the collection as a whole. [ABSTRACT FROM AUTHOR]

In recent years, the solid-state electro-thermal storage device has been connected to the power supply side of the power system for peak regulation by virtue of its high voltage and large capacity characteristics, which plays a positive role in the consumption of wind power, photovoltaic and other new energy. Based on the coupling effects of heat, current, electricity, magnetism, force and other physical fields in the equipment, this paper studies the optimal design of thermal storage structure. A multi-physical field and multi-criteria collaborative optimization design method was proposed to design the surface load of heating power, heat transfer channel of heat storage body, and porosity of body. Through the multi-field coupling numerical simulation and experiment verification, the thermal field, flow field, stress field, electric field and other changes are analyzed, and it is verified that the design method can effectively overcome the malpractice of low heat transfer rate temperature imbalance of thermal storage materials. The experimental results provide theoretical guidance for device design and engineering application.

Organ transplants have been a life-saving form of treatment for many patients who are facing end stage organ failure due to conditions such as diabetes, hypertension, various congenital diseases, idiopathic diseases, traumas, and other end-organ failure. While organ transplants have been monumental in treatment for these conditions, the ten year survival and long-term outcome for these patients is poor. After receiving the transplant, patients receive a multi-drug regimen of immunosuppressants. These drugs include cyclosporine, mTOR inhibitors, corticosteroids, and antibodies. Polyclonal antibodies, which inhibit the recipient's B lymphocytes, and antibodies targeting host cytokine inhibitors which prevent activation of B cells by T cells. Use of these drugs suppresses the immune system and increases the risk of opportunistic pathogen infections, tumors, and further damage to the transplanted organs and vasculature. Many regulatory mechanisms are present in organs to prevent the development of autoimmune disease, and Tregs are central to these mechanisms. Tregs secrete suppressive cytokines such as IL-10, TGF-B, and IL-35 to suppress T cells. Additionally, Tregs can bind to target cells to induce cell cycle arrest and apoptosis and can inhibit induction of IL-2 mRNA in target T cells. Tregs also interact with CTLA-4 and CD80/CD86 on antigen presenting cells (APCs) to prevent their binding to CD28 present on T cells. Due to their various immunosuppressive capabilities, Tregs are being examined as a possible treatment for patients that receive organ transplants to minimize rejection and prevent the negative outcomes. Several studies in which participants were given Tregs after undergoing organ transplantations were reviewed to determine the efficacy and safety of using Tregs in solid organ transplantation to prevent adverse outcomes. [ABSTRACT FROM AUTHOR]

In this paper, the parameters of microtextured tools were studied in the threading of aluminum 7075-T6 alloy. The primary focus of this work is to optimize the parameters of microtextured tools using the RSM method to produce high-accuracy threaded parts. Microtextures were generated through laser micromachining on the rake surface of carbide inserts. Geometric parameters considered were diameter, depth, and distance of microtextures and lubricant type. The maximum deflection of the workpiece in the cutting process was considered as the output of experiments. Optimal microtexture factors were obtained using the RSM method. Based on optimization results, the optimal level of diameter, depth, and distance of microtextures is 95, 15, and 50 µm, respectively, and the microhole-textured CNT-embedded tool is more efficient than MoS2-embedded tool and traditional tools. Our results reveal that the maximum deflection of the workpiece reduced up to 40.2% as the microhole-textured CNT-embedded tool is applied in this process. [ABSTRACT FROM AUTHOR]

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Is rated about (10-25 %) Of these wastes as hazardous and can affect the public health environment and pollution in particular, the medical waste m n this hospital if it is not handled properly can cause health problems for health workers in the hospital and for the patients and the community. Medical waste consists of hazardous waste and non - hazardous wastes include waste and hazardous waste infectious, disease, drugs, sharp tools, chemicals, toxic waste genetic and radioactive either non - hazardous waste fats included garbage and general daily waste of residues of food, materials, office and other. [ABSTRACT FROM AUTHOR]

Purpose: To establish a non-invasive diagnostic model based on convolutional neural networks (CNNs) to distinguish benign from malignant lesions manifesting as a solid, indeterminate solitary pulmonary nodule (SPN) or mass (SPM) on computed tomography (CT). Method: A total of 459 patients with solid indeterminate SPNs/SPMs on CT were ultimately included in this retrospective study and assigned to the train (n=366), validation (n=46), and test (n=47) sets. Histopathologic analysis was available for each patient. An end-to-end CNN model was proposed to predict the natural history of solid indeterminate SPN/SPMs on CT. Receiver operating characteristic curves were plotted to evaluate the predictive performance of the proposed CNN model. The accuracy, sensitivity, and specificity of diagnoses by radiologists alone were compared with those of diagnoses by radiologists by using the CNN model to assess its clinical utility. Results: For the CNN model, the AUC was 91% (95% confidence interval [CI]: 0.83–0.99) in the test set. The diagnostic accuracy of radiologists with the CNN model was significantly higher than that without the model (89 vs. 66%, P<0.01; 87 vs. 61%, P<0.01; 85 vs. 66%, P=0.03, in the train, validation, and test sets, respectively). In addition, while there was a slight increase in sensitivity, the specificity improved significantly by an average of 42% (the corresponding improvements in the three sets ranged from 43, 33, and 42% to 82, 78, and 84%, respectively; P<0.01 for all). Conclusion: The CNN model could be a valuable tool in non-invasively differentiating benign from malignant lesions manifesting as solid, indeterminate SPNs/SPMs on CT. [ABSTRACT FROM AUTHOR]

• MIP and SOL subtypes are associated with poor prognosis. • Preoperative identification of MIP/SOL components help decide the treatment plan. • Cryobiopsy can collect larger tissue samples with less crush artifacts. • Concordance is higher for primary or secondary predominant patterns. • Cryobiopsy reliably identifies MIP/SOL components in early-stage lung adenocarcinoma. Micropapillary (MIP) and solid (SOL) subtypes of early-stage lung adenocarcinomas are associated with lymph node metastasis and local recurrence after limited resection. Preoperative identification of these components may influence the decisions of treatment strategy, additional lymph node evaluation, indication for limited resection, and extent of lymph node dissection. However, conventional biopsy specimens are insufficient for identifying these subtypes, especially MIP components. Cryobiopsy can collect larger tissue samples with fewer crush artifacts than conventional forceps biopsy, which would be helpful for detecting MIP/SOL components. Thus, this study aimed to analyze the feasibility of using cryobiopsy for MIP/SOL subtype detection. Consecutive patients who underwent surgery for clinical IA lung cancer following a preoperative diagnosis of adenocarcinoma by cryobiopsy at our institution between October 2017 and July 2019 were retrospectively examined. The concordance rate of MIP/SOL subtypes between the specimens obtained by cryobiopsy and surgery was investigated. In total, 115 patients were evaluated. There were 26 (22.6%) and 14 (12.2%) patients with MIP and SOL subtypes, respectively. For concordance of MIP/SOL subtypes, the sensitivity was 65.7% (95% confidence interval [CI]: 57.7–65.7%). For the primary or secondary predominant patterns, a more satisfactory concordance rate of 72.2% (95% CI: 52.6–86.2%) was obtained. On assessing each subtype, high sensitivity was noted in SOL-predominant patterns (85.7%, 95% CI: 56.5%–96.0%) and MIP-secondary predominant patterns (83.3%, 95% CI: 45.8–97.0%). However, SOL-secondary predominant patterns revealed low sensitivity (0%, 95% CI, 0–38.2%). Overall, the MIP subtypes had higher sensitivity than the SOL subtypes (65.4% vs. 50.0%). Cryobiopsy could be reliable for identifying MIP/SOL components, especially the MIP component, in clinical stage IA adenocarcinomas. [ABSTRACT FROM AUTHOR]

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The thermodynamic property data for solid phase I of benzene are reviewed and utilized to develop a new fundamental equation of state (EOS) based on Helmholtz energy, following the methodology used for solid phase I of CO2 by Trusler [J. Phys. Chem. Ref. Data 40, 043105 (2011)]. With temperature and molar volume as independent variables, the EOS is able to calculate all thermodynamic properties of solid benzene at temperatures up to 470 K and at pressures up to 1800 MPa. The model is constructed using the quasi-harmonic approximation, incorporating a Debye oscillator distribution for the vibrons, four discrete modes for the librons, and a further 30 distinct modes for the internal vibrations of the benzene molecule. An anharmonic term is used to account for inevitable deviations from the quasi-harmonic model, which are particularly important near the triple point. The new EOS is able to describe the available experimental data to a level comparable with the likely experimental uncertainties. The estimated relative standard uncertainties of the EOS are 0.2% and 1.5% for molar volume on the sublimation curve and in the compressed solid region, respectively; 8%–1% for isobaric heat capacity on the sublimation curve between 4 K and 278 K; 4% for thermal expansivity; 1% for isentropic bulk modulus; 1% for enthalpy of sublimation and melting; and 3% and 4% for the computed sublimation and melting pressures, respectively. The EOS behaves in a physically reasonable manner at temperatures approaching absolute zero and also at very high pressures. [ABSTRACT FROM AUTHOR]

Abstract Objectives The availability of matched sequencing data for the same sample across different sequencing platforms is a necessity for validation and effective comparison of sequencing platforms. A commonly sequenced sample is the lab-adapted MG1655 strain of Escherichia coli; however, this strain is not fully representative of more complex and dynamic genomes of pathogenic E. coli strains. Data description We present six new sequencing data sets for another E. coli strain, UTI89, which is an extraintestinal pathogenic strain isolated from a patient suffering from a urinary tract infection. We now provide matched whole genome sequencing data generated using the PacBio RSII, Oxford Nanopore MinION R9.4, Ion Torrent, ABI SOLiD, and Illumina NextSeq sequencers. Together with other publically available datasets, UTI89 has a nearly complete suite of data generated on most second- and third-generation sequencers. These data can be used as an additional validation set for new sequencing technologies and analytical methods. More than being another E. coli strain, however, UTI89 is pathogenic, with a 10% larger genome, additional pathogenicity islands, and a large plasmid, features that are common among other naturally occurring and disease-causing E. coli isolates. These data therefore provide a more medically relevant test set for development of algorithms.

The Solid (Social Linked Data) project focuses on data sharing and privacy security and aims to build a decentralized ecosystem that radically changes the way web applications work today. Our goal is to introduce a “trust access authentication system” to achieve secure authentication and fine-grained access control, thereby promoting the implementation of Solid. Blockchain, equipped with multiple security properties and authentication functions, is a crucial technology. In this paper, we present a blockchain-assisted system for secure authentication in Solid and for implementation of fine-grained access control policies. Specifically, we explore to integrate threshold RSA signatures in a permissioned blockchain system to enable a fault-tolerant distributed signature scheme, thereby enhancing the resilience and robustness of authentication system. Moreover, we utilize smart contract to control transaction flows and manage access control policies automatically. Experimental results show that our proposed trust access authentication system enhances security, scales well, and is efficient and economically feasible.

Until 2026, the annual rate of municipal solid waste production will increase and the per capita waste generation in Iran will be 0.6 kg/person.day. In this paper, the process of conversion of waste-to-energy in Iran is investigated and the future situation is estimated. Also, the trend of waste management methods and energy production are evaluated. At the end, the benefits of the waste-to-energy process at the capital of Iran (Tehran) are observed. Waste-to-Energy (WTE) facilities in waste management are used within 3 regions of 22 metropolitan areas of Tehran and serve 950,000 citizens. With manufacturing new WTE plants in Iran, it would be possible to prevent the burning of about 15 million barrels of oil or 255⨯107 cubic meters of natural gas annually and use these fossil fuels to produce petrochemicals and export them. The associated overall expenses of WTE is also estimated in different countries at a rate of GDP between 300 and 3,000 $ per ton of MSW. By substituting WTE plants instead of oil basic plants, can reduce about 0.13 kg/kWh CO2 emissions. While most of the power plants are gas basic, that will have an increase of CO2 emissions of about 0.19 kg / kWh.

Organ transplants have been a life-saving form of treatment for many patients who are facing end stage organ failure due to conditions such as diabetes, hypertension, various congenital diseases, idiopathic diseases, traumas, and other end-organ failure. While organ transplants have been monumental in treatment for these conditions, the ten year survival and long-term outcome for these patients is poor. After receiving the transplant, patients receive a multi-drug regimen of immunosuppressants. These drugs include cyclosporine, mTOR inhibitors, corticosteroids, and antibodies. Polyclonal antibodies, which inhibit the recipient’s B lymphocytes, and antibodies targeting host cytokine inhibitors which prevent activation of B cells by T cells. Use of these drugs suppresses the immune system and increases the risk of opportunistic pathogen infections, tumors, and further damage to the transplanted organs and vasculature. Many regulatory mechanisms are present in organs to prevent the development of autoimmune disease, and Tregs are central to these mechanisms. Tregs secrete suppressive cytokines such as IL-10, TGF-B, and IL-35 to suppress T cells. Additionally, Tregs can bind to target cells to induce cell cycle arrest and apoptosis and can inhibit induction of IL-2 mRNA in target T cells. Tregs also interact with CTLA-4 and CD80/CD86 on antigen presenting cells (APCs) to prevent their binding to CD28 present on T cells. Due to their various immunosuppressive capabilities, Tregs are being examined as a possible treatment for patients that receive organ transplants to minimize rejection and prevent the negative outcomes. Several studies in which participants were given Tregs after undergoing organ transplantations were reviewed to determine the efficacy and safety of using Tregs in solid organ transplantation to prevent adverse outcomes.

The article presents materials from the laboratory and field studies of the Samara State Agrarian University on the effectiveness of liquid mineral nitrogen and new nitrogen-sulfur fertilizers based on KAS-32 compared with solid fertilizers – ammonium nitrate produced by PAO KuibyshevAzot (Tolyatti, Samara oblast) in the cultivation of cereal crops (durum wheat ) and legumes (soybeans) using MINI-TILL technology provided by the agricultural machinery complex AO Evrotehnika (Samara) of the German company AMAZONEN-Werke (Germany). Objective: to determine the effectiveness of nitrogen liquid mineral fertilizers produced by PAO KuibyshevAzot and new nitrogen-sulfur fertilizers in comparison with traditional solid mineral fertilizers – ammonium nitrate – with the determination of the optimal doses, methods and time of application, the necessary technical means for various crops, including cereals and legumes. In the dry year of 2018 (the seventh drought year since 1936), fairly high results were obtained in terms of yield and quality of the products when using KAS-32, KAS-32 with sulfur and RPS (sulfur-containing nutritious solution) in comparison with solid mineral fertilizers (ammonia nitrate) when applied by AO Eurotechnika sprayers equipped with large-droplet sprayers and extension hoses for foliar and nonroot (root) dressing of plants.

PurposeTo establish a non-invasive diagnostic model based on convolutional neural networks (CNNs) to distinguish benign from malignant lesions manifesting as a solid, indeterminate solitary pulmonary nodule (SPN) or mass (SPM) on computed tomography (CT).MethodA total of 459 patients with solid indeterminate SPNs/SPMs on CT were ultimately included in this retrospective study and assigned to the train (n=366), validation (n=46), and test (n=47) sets. Histopathologic analysis was available for each patient. An end-to-end CNN model was proposed to predict the natural history of solid indeterminate SPN/SPMs on CT. Receiver operating characteristic curves were plotted to evaluate the predictive performance of the proposed CNN model. The accuracy, sensitivity, and specificity of diagnoses by radiologists alone were compared with those of diagnoses by radiologists by using the CNN model to assess its clinical utility.ResultsFor the CNN model, the AUC was 91% (95% confidence interval [CI]: 0.83–0.99) in the test set. The diagnostic accuracy of radiologists with the CNN model was significantly higher than that without the model (89 vs. 66%, P

Introduction: Acinic cell carcinoma (AciCC) is a rare clinical entity and a salivary gland malignancy. It is associated with wide histological variations in the cytomorphological patterns., Methods: Sixty cases diagnosed as AciCC from 2002 to 2023 were assessed for diverse cytomorphological patterns., Results: The mean age of patients at the time of diagnosis was 44.35±16.8 years ranging from 15 to 81 years. Females comprised 58.3% for a F: M ratio of 1.4:1. Fifty three cases (88.3%) occurred in the parotid gland, two cases in the nasal region (3.3%), and one case each in the soft plate and upper lip (1.7%). The location of the remaining three cases was not specified. The most common presenting complaint was a well-defined facial swelling associated with pain. The average tumor size was 3.8±1.9 cm. The most predominant architectural pattern was solid (83.3%) followed by microcystic (60%), then follicular (41.7%), papillary cystic (14.3%), and tubulocystic (28.6%), and AciCC with de-differentiation/high-grade transformation was reported in three cases (5%). In 83.3% of the cases (50 out of 60), we noticed a mixture of two or more growth patterns. Other degenerative changes included prominent lymphoid stroma, hemorrhage, and cystic change., Conclusion: Awareness and recognition of diverse cytomorphological patterns of AciCC, especially in institutions of a developing country where there is limited availability of highly specific and sensitive immunohistochemical stains or molecular diagnostics, are crucial and essential., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Aga Khan University Ethics Review Committe issued approval 2023-7495-27326. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Suleman et al.)

A large class of solid solution models are formulated on the premise that exchange of chemical species takes place on a finite number of unique crystallographic sites, and that the thermodynamic properties of the solution are a function of the proportions of species occupying each of the sites. These models are broadly classified as being of Bragg–Williams-type. They form an excellent first order approximation of non-ideal mixing and long-range order. In this article we present the mathematical framework common to all Bragg–Williams models, introducing necessary concepts from geometry, set theory and linear algebra. We combine this with a set of mathematical tools which we have found useful in building and using such models. We include several worked examples to illustrate key concepts and provide general expressions which can be used for all models. This paper is split into two parts. In the first part, we show how the valences of the species occupying each site and the total charge of the species involved in site exchange are sufficient to define the space of valid site occupancies of a solid solution, and to compute the endmembers bounding that space. We show that this space can be visualised as a polytope, i.e, an n-dimensional polyhedron, and we describe the relationship between site-occupancy space and compositional space. In the second part of the paper, we present the linear algebra required to transform descriptions of modified van Laar and subregular solution models from one independent endmember basis to another. The same algebra can also be used to derive macroscopic endmember interactions from microscopic site interactions. This algebra is useful both in the initial design of solution models, and when performing thermodynamic calculations in restricted chemical subsystems. A polytope description of solid solutions is used in the thermodynamic software packages Perple_X and burnman. The algorithms described in this paper are made available as python code. [ABSTRACT FROM AUTHOR]

This study aims to identify the amount of solid waste generation, composition, and characteristics of the Buleleng sub-district waste. The results of the identification of existing condition were used to predict future waste generation and the planning process for waste management in Buleleng sub-district. Primary data were collected by sampling method of waste generation and composition at household and non-household sources, observation of existing waste management, interviews, and questionnaires. Secondary data were collected from the Environmental Agency and Statistical Agency of Buleleng Regency. The results of the research show that the waste generation in Buleleng sub-district reaches 114.85 tons/day, with the largest percentage of waste sources from household activities and traditional markets. Organic waste is dominated waste composition by 69.47%. Waste generation in 2040 is estimated to reach 154.9 tons/day, so it is necessary to plan a waste processing facility to reduce the amount of waste that must process in the landfill. The waste management plan considered the target of reducing waste by 2025 by 30%, based on Presidential Regulation No.97 of 2017. The planning used a moderate scenario and the simulation results can achieve the waste reduction target of 52.52% by 2040. [ABSTRACT FROM AUTHOR]

Chemically defined media are reconstituted batchwise and stored in hold tanks until use. To avoid large hold tanks and batchwise production of media, we developed continuous on‐demand reconstitutions directly from solids consisting of a hopper and a screw conveyor capable of feeding dry powdered media with the required precision ±5% at low dosing rates of 0.171 g min−1. A commercially available dry powdered cell culture medium was continuously fed over a duration of 12 h into a mixer which was connected to a UV‐cell for monitoring and the media were compared to a batchwise production. A comparable amino acid, carbohydrate, and osmolality profile to a batchwise reconstitution could be obtained. Cell cultivation showed comparable performance of batch and continuous reconstitution for two CHO cell lines producing the antibodies adalimumab and trastuzumab on a small and benchtop scale. In‐depth analysis of the produced antibodies showed the same glycosylation pattern, other posttranslational profiles such as methionine oxidation and deamidation compared to batchwise reconstitution. Therefore, we conclude a continuous reconstitution of the medium results in the same quality of the product. A continuous on‐demand media reconstitution will impact the supply chain and significantly reduce the floor space necessary for preparation and storage. [ABSTRACT FROM AUTHOR]