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As scholars work to decolonize educational research, new methodologies are needed. In this paper, we present our conceptual premises for a new paradigm, social portraiture, which combines participatory action research (Freire, 1982) and portraiture (Lawrence-Lightfoot & Hoffmann, 1997), and extends to include archival records and social art. This democratic approach integrates student participation, community engagement, and social change, coalescing into an integrated portrait of human experience in education. Our ideas contribute to foundations in arts-based methods in participatory action research, seeking transformative change in educational world views, ways of knowing, and institutional ways of life. [ABSTRACT FROM AUTHOR]

A new orthodontic index was proposed by the College of Diplomates to assess the degree of difficulty of cases submitted for the Indian Board of Orthodontics Phase III clinical examinations. This article is the continuation of the part 1 article which gave a brief insight into the need and the methodology undertaken to formulate this index. A weightage score grading the degree of severity of a case was obtained for dental, cephalometric, and miscellaneous components based on the results of a survey taken from the Diplomates of the Indian Board of Orthodontics. An aesthetic component was also developed using photographs and the relative aesthetic score for every photograph was graded. This index would help to categorize the malocclusion based on the severity, in a single, linear, and transparent manner. [ABSTRACT FROM AUTHOR]

Plastic film mulching (PFM) affects the spatiotemporal distribution of soil moisture and temperature, which in turn affects cotton growth and the spatiotemporal distribution of canopy photosynthetically active radiation (PAR). Due to the spatial heterogeneity of soil moisture, temperature and limited monitoring methods, the issues such as relatively few sampling points and long sampling intervals in most existing studies prevent the accurate quantification of spatiotemporal changes in moisture and temperature along soil profile. To investigate the effects ofPFMon spatiotemporal changes in soil moisture, temperature, and canopy PAR in cotton fields, two field trials of plastic film-mulched (M) and nonmulched (NM) cultivations were performed in 2018 and 2019. The grid method was used for the soil information continuous monitoring and multiple-time fixed-site canopy PAR monitoring during the duration of cotton growth. Two-year field trial data showed that, M cultivation increased soil moisture by approximately 13.6%-25% and increased temperature by 2-4 °C in the 0-50 cm soil layer before the first irrigation (June 20) and by 1-2 °C in the 70-110 cm soil layer, compared with NM cultivation. In addition, the temperature difference between the two treatments gradually decreased with the increase in irrigation and air temperature. TheMtreatment reached the peak PAR interception rate 10 days earlier than the NM treatment. In 2018 and 2019, the PAR peak value under the M treatment was 4.62% and 1.8% higher than that under the NM treatment, respectively, but the PAR interception rate was decreased rapidly in the late growth stage. Overall, PFM had an effect on soil moisture retention during the whole growth period and greatly increased the soil temperature before budding stage, thus promoted the early growth of cotton. Considering this, we suggest that the irrigation quota and frequency could be appropriately decreased in the case of plastic film mulching cultivation. For nonmulching cultivation, the irrigation quota and frequency should be increased, and it is necessary to take measures to improve the soil temperature before middle July. [ABSTRACT FROM AUTHOR]

How can researchers do more than 'do no harm' and have a positive impact in the contexts in which they intervene? These are classic questions of PAR, which also apply to peace research. How can research practice contribute to peace? There is an intimate relationship between power, violence and silence. Hence, working with subalternised voices, subject to epistemic violence, poses a methodological challenge for social sciences in which words are data. This paper presents a research method that allows for constructive confrontation in contexts of terrorist violence in European cities, generally considered to be at peace. This method consists of organising public debate in collaboration with community organisations in a neighbourhood directly affected by the aftermath of a wave of terrorist attacks in France. In the case of the Université Populaire, the organisation of public debates allowed for the public expression of agonism, and was a source of hope and prefigurative politics. Exploring this case, this article contributes to discussions about how to deal with the challenges of pluralism within current peace research. [ABSTRACT FROM AUTHOR]

Green microalgae are important sources of natural products and are attractive cell factories for manufacturing high-value products such as recombinant proteins. Increasing scales of production must address the bottleneck of providing sufficient light energy for photosynthesis. Enhancing the photosynthetic action spectrum of green algae to improve the utilisation of yellow light would provide additional light energy for photosynthesis. Here, we evaluated the Katushka fluorescent protein, which converts yellow photons to red photons, to drive photosynthesis and growth when expressed in Chlamydomonas reinhardtii chloroplasts. Transplastomic algae expressing a codon-optimised Katushka gene accumulated the active Katushka protein, which was detected by excitation with yellow light. Removal of chlorophyll from cells, which captures red photons, led to increased Katushka fluorescence. In yellow light, emission of red photons by fluorescent Katushka increased oxygen evolution and photosynthetic growth. Utilisation of yellow photons increased photosynthetic growth of transplastomic cells expressing Katushka in light deficient in red photons. These results showed that Katushka was a simple and effective yellow light-capturing device that enhanced the photosynthetic action spectrum of C. reinhardtii. [ABSTRACT FROM AUTHOR]

ADP-ribosylation is a post-translational modification involving the transfer of one or more ADP-ribose units from NAD+ to target proteins. Dysregulation of ADP-ribosylation is implicated in neurodegenerative diseases. In this study, genetic testing via exome sequencing was used to identify the underlying disease in two siblings with developmental delay, seizures, progressive muscle weakness, and respiratory failure following an episodic course. This identified a novel homozygous variant in the ADPRS gene (c.545A>G, p.His182Arg) encoding the mono(ADP-ribosyl) hydrolase ARH3, confirming the diagnosis of childhood-onset neurodegeneration with stress-induced ataxia and seizures (CONDSIAS) in these 2 children. Mechanistically, the ARH3 H182R variant affects a highly conserved residue in the active site of ARH3, leading to protein instability, degradation, and subsequently, reduced protein expression. The ARH3 H182R mutant additionally fails to localize to the nucleus, which further resulted in accumulated mono-ADP ribosylated species in cells. The children's clinical course combined with the biochemical characterization of their genetic variant develops our understanding of the pathogenic mechanisms driving CONDSIAS and highlights a critical role for ARH3-regulated ADP ribosylation in nervous system integrity., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)

Objective: Developing an appropriate context-based school-age obesity prevention programme, understanding the root causes of obesity in real-life situations is vital. The objectives of this study were to explore the risk factors of school-age obesity based on Ecological System Theory (EST) and develop mutual problem-solving guidelines for school-age obesity prevention., Methods: Participation Action Research (PAR) was used as the study design. The data collection employed focus group discussions, in-depth interviews, participant's observations, together with the procedures of Appreciation, Influence, and Control (AIC) with 55 school key informants., Results: Risk factors supported by EST at all level included high-calorie intake; sedentary lifestyles; perceptions of 'Chubby are cute'; indulgent parenting, including limited exercise area in school. PAR process guarantees the sustained context-based prevention guidelines., Conclusions: The results could be used as a policy-driven for school-based participation and environmental support in order to promote health-promoting school.

Simple Summary: Poly(ADP-ribose) (PAR) functions in genome repair, cell metabolism, and cancer treatment; however, in vivo molecular tools to assess PAR levels are not readily available. Here, we describe two methods to measure PAR with high sensitivity in real time in vivo using the PAR binding domain (termed WWE) of Ring Finger Protein 146 (RNF146). In response to genotoxic stress, the WWE-EGFP fusion protein, termed LivePAR, displays nuclear enrichment enabling quantitative and visual detection of PAR formation. Additionally, a split luciferase assay using the same WWE domain facilitates rapid PAR quantitation in a plate format and provides a tool for chemotherapeutic candidate compound screening. Both tools can be used to identify genetic determinants of PAR formation and help in identifying compounds that alter PAR formation or degradation. Poly(ADP-ribose) (PAR) is a molecular scaffold that aids in the formation of DNA repair protein complexes. Tools to sensitively quantify PAR in live cells have been lacking. We recently described the LivePAR probe (EGFP fused to the RNF146-encoded WWE PAR binding domain) to measure PAR formation at sites of laser micro-irradiation in live cells. Here, we present two methods that expand on the use of LivePAR and its WWE domain. First, LivePAR enriches in the nucleus of cells following genotoxic challenge. Image quantitation can identify single-cell PAR formation following genotoxic stress at concentrations lower than PAR ELISA or PAR immunoblot, with greater sensitivity to genotoxic stress than CometChip. In a second approach, we used the RNF146-encoded WWE domain to develop a split luciferase probe for analysis in a 96-well plate assay. We then applied these PAR analysis tools to demonstrate their broad applicability. First, we show that both approaches can identify genetic modifications that alter PARylation levels, such as hyper-PARylation in BRCA2-deficient cancer cells. Second, we demonstrate the utility of the WWE split luciferase assay to characterize the cellular response of genotoxins, PARP inhibitors, and PARG inhibitors, thereby providing a screening method to identify PAR modulating compounds. [ABSTRACT FROM AUTHOR]

Background Folate-mediated 1-carbon metabolism requires several nutrients, including vitamin B6. Circulating biomarker concentrations indicating high vitamin B6 status are associated with a reduced risk of colorectal cancer (CRC). However, little is known about the effect of B6 status in relation to clinical outcomes in CRC patients. Objectives We investigated survival outcomes in relation to vitamin B6 status in prospectively followed CRC patients. Methods A total of 2031 patients with stage I–III CRC participated in 6 prospective patient cohorts in the international FOCUS (folate-dependent 1-carbon metabolism in colorectal cancer recurrence and survival) Consortium. Preoperative blood samples were used to measure vitamin B6 status by the direct marker pyridoxal 5′-phosphate (PLP), as well as the functional marker HK-ratio (HKr)[3′-hydroxykynurenine: (kynurenic acid + xanthurenic acid + 3′-hydroxy anthranilic acid + anthranilic acid)]. Using Cox proportional hazards regression, we examined associations of vitamin B6 status with overall survival (OS), disease-free survival (DFS), and risk of recurrence, adjusted for patient age, sex, circulating creatinine concentrations, tumor site, stage, and cohort. Results After a median follow-up of 3.2 y for OS, higher preoperative vitamin B6 status as assessed by PLP and the functional marker HKr was associated with 16–32% higher all-cause and disease-free survival, although there was no significant association with disease recurrence (doubling in PLP concentration: HROS, 0.68; 95% CI: 0.59, 0.79; HRDFS, 0.84; 95% CI: 0.75, 0.94; HRRecurrence, 0.96; 95% CI: 0.84, 1.09; HKr: HROS, 2.04; 95% CI: 1.67, 2.49; HRDFS, 1.56; 95% CI: 1.31, 1.85; HRRecurrence, 1.21; 95% CI: 0.96,1. 52). The association of PLP with improved OS was consistent across colorectal tumor site (right-sided colon: HROS, 0.75; 95% CI: 0.59, 0.96; left-sided colon: HROS, 0.71; 95% CI: 0.55, 0.92; rectosigmoid junction and rectum: HROS, 0.61; 95% CI: 0.47, 0.78). Conclusion Higher preoperative vitamin B6 status is associated with improved OS among stage I–III CRC patients. [ABSTRACT FROM AUTHOR]

This study served to conceptualize neurodisability (ND) navigation-building. Capacity-building toward wide-reaching ND navigation or help-seeking service lacks empirical evidence. Researchers widely agree that a system-wide framework is absent. While research emphasizes service-level findings, other jurisdiction- and policy-level insights are lacking. Using Collective Community Impact and Participatory Action Research, government and nongovernment organizations in three Canadian regions implemented novel cross-jurisdictional initiatives to improve navigation capacity. Family-partners and other stakeholders systematically engaged in discussions. Grounded in qualitative thematic design, we sought to unveil connections between emerging themes. These themes led to stakeholders co-constructing an intersectoral navigation-building conceptualization. A framework was essential for highlighting change-levers and potential replication in other jurisdictions/landscapes. Finally, practice and policy implications compatible with an ecosystem model are presented. [ABSTRACT FROM AUTHOR]

The terrestrial biosphere plays an active role in governing the climate system by regulating carbon exchange between the land and the atmosphere. Analysis of vegetation biophysical parameters and gross primary production (GPP) makes it convenient to monitor vegetation's health. A light use efficiency (LUE) model was employed to estimate daily GPP from satellite-driven data and environmental factors. The LUE model is driven by four major variables, namely normalized difference vegetation index (NDVI), photosynthetically active radiation (PAR), air temperature, and moisture for which both satellite-based and ERA5-Land data were applied. In this study, the vegetation health of Dibru Saikhowa National Park (DSNP) in Assam has been analyzed through vegetation biophysical and biochemical parameters (i.e., NDVI, EVI, LAI, and chlorophyll content) using Sentinel-2 data. Leaf area index (LAI) varied between 1 and 5.2, with healthy forests depicted LAI more than 2.5. Daily GPP was estimated for January (winter) and August (monsoon) 2019 for tropical evergreen and deciduous forest types. A comparative analysis of GPP for two seasons has been performed. In January, GPP was found to be 3.6 gC m−2 day−1, while in August, GPP was 5 gC m−2 day−1. The outcome of this study may be constructive to forest planners to manage the National Park so that net carbon sink may be attained in DSNP. [ABSTRACT FROM AUTHOR]

Expectations and demands on coproduction in research have increased. Therefore, there is a need for knowledge on how these coproducing processes where researchers and practitioners work side by side during the research process can be carried out. In this article, methodological questions related to coproduction and collaboration between researchers and practitioners in the field of social work are raised and discussed. The article draws on an on-going research project where participatory action research (PAR) is the leading guideline. PAR in a contemporary context is understood as a democratization process, where values such as participation, mutual learning, empowerment, improvement and development of practice are given as much attention as the actual research findings. The research project discussed takes its starting point in Swedish eldercare, investigating situations of moral stress and moral agency. The project is carried out in close cooperation with three municipalities and institutions where future staff for eldercare are trained (social workers and auxiliary nurses). In the article the relations between researchers and practitioners are discussed. Strategies on how to establish cooperation applying a synergistic approach are highlighted. Furthermore, strategies for dissemination or research results are discussed. The article suggests PAR as a specific social work signature methodology, as PAR acknowledges the need for relational work as well as an action-oriented research agenda, well in line with the core values and understanding of social work as a professional practice and academic discipline. In the article, applying PAR in a contemporary context, is understood as a key component when striving for socially robust knowledge; that is, knowledge that is considered relevant and reliable in the eyes of all actors involved, in this case staff in municipal eldercare, as well as in academia. [ABSTRACT FROM AUTHOR]

The structure, the phase composition, and the mechanical properties of high-strength austenitic steel 05S–(21–22)Cr–15Mn–8Ni–(1–2)Mo–V–N (05Kh(21–22)AG15N8MF grade) having an equilibrium nitrogen content of 0.5% (which is below the solubility limit under standard conditions) and melted in an open induction furnace are studied in the cast, hot-deformed, and heat-treated states. The steel having the same metallic base and a overequilibrium nitrogen content of 0.65–0.79% (which is above the solubility limit under standard conditions) and melted in a plasma arc furnace is also analyzed. The mechanical properties of these steel versions, including the impact toughness at low test temperatures, are compared, and their relationship with the structural-phase state of the steels is analyzed. The hot-forged steels exhibit an increase in the strength with the nitrogen concentration and a symmetrical decrease in the impact toughness. An increase in the forging reduction ratio of steel with 0.7% N is found to increase the yield strength and ultimate tensile strength but to decrease the cold resistance. The grain size and the presence of a nitride phase, which precipitates at the temperatures of the end of hot forging, exert a significant effect on the level of properties. To achieve a good combination of high strength properties and cold resistance, the nitrogen concentration in 05Kh21AG15N8MF steel should not to exceed 0.65%. [ABSTRACT FROM AUTHOR]

Previous epidemiological studies have focused on the association of dietary vitamin B6 or circulating pyridoxal-5′-phosphate (PLP) with colorectal cancer risk. This study aimed to investigate the vitamin B6 in relation to colorectal cancer risk combining the biomarkers of PLP, pyridoxal (PL) plus PLP, and PAr (the ratio of 4-pyridoxic acid over the sum of PLP and PL). A large-scale hospital-based case-control study was conducted in Guangdong Province, China, which included 1233 colorectal cancer cases and 1245 sex and age frequency-matched controls. Serum PLP, PL, and 4-pyridoxic acid (PA) were detected with ultra-high-performance liquid chromatography–tandem mass spectrometry. Unconditional logistic regression models were used to assess the odds ratios (ORs) and 95% confidence intervals (95% CIs). Serum PLP and the sum of PLP and PL were inversely associated with colorectal cancer risk, while PAr was positively associated with colorectal cancer risk. Comparing the highest with the lowest quartile, the adjusted OR (95% CI) was 0.26 (0.20–0.33, Ptrend < 0.001) for serum PLP, 0.51 (0.40–0.66, Ptrend < 0.001) for serum PLP plus PL, and 2.90 (2.25–3.75, Ptrend < 0.001) for PAr. Serum PLP and PAr had significantly stronger associations with colorectal cancer risk in the male group and smoking group. Our results supported the protective role of vitamin B6 in colorectal cancer risk among Chinese people. The positive association of PAr with colorectal cancer risk suggested the potential role of inflammation and oxidative stress in colorectal carcinogenesis. [ABSTRACT FROM AUTHOR]

Aims: Limited epidemiological data on the combined impact of several lifestyle factors on type 2 diabetes (T2D) incidence was reported in Chinese population. This study aimed to examine how combinations of BMI, physical activity and diet relate to T2D incidence and estimate corresponding population attributable risk in the general population. Methods: A total of 56,691 male and 70,849 female participants aged 40–74 years old in two population‐based cohorts from the Shanghai Men's and Women's Health Studies were used for analysis. The Cox regression model was used to estimate the association between lifestyle factors collected at baseline and T2D incidence. Multivariable‐adjusted population attributable risks were calculated for specific combinations of lifestyle factors. Results: There were 3315 male and 5925 female incident T2D, with corresponding density incidence rates of 6.39 and 6.04 per 1000 person‐years. If the healthiest group of healthy lifestyle index (HLI) was used as a reference, the hazard ratios (95% confidence intervals) of T2D increased monotonically in men [2.04 (1.75, 2.38); 2.94 (2.53, 3.42); 4.31 (3.66, 5.07)] and women [1.85 (1.64, 2.08); 2.79 (2.49, 3.13); 4.14 (3.66, 4.67)]. One point increase of HLI was related to 35% and 35% lower risk in men and women. About 52.7% and 58.4% cases in men and women could have been avoided if participants had been adherent to a healthy lifestyle of maintaining healthy body weight, eating a healthy diet and keeping physically active. Conclusions: An increased number of healthy lifestyle factors were associated with a decreased risk of T2D in the Chinese population. Future interventions targeted at combined healthy lifestyle factors are needed to reduce the burden of T2D. [ABSTRACT FROM AUTHOR]

PI-3 Kinase plays an important role in platelet activation mainly through regulation of RASA3. Akt phosphorylation is an indicator for the activity of PI3 kinase. The aim of this study is to characterize the pathways leading to Akt phosphorylation in platelets. We performed concentration response curves of LY294002, a pan-PI3 kinase inhibitor, on platelet aggregation and Akt phosphorylation, in washed human and mouse platelets. At concentrations as low as 3.12 µM, LY294002 abolished Akt phosphorylation induced by 2MeSADP and SFLLRN, but not by AYPGKF. It required much higher concentrations of LY294002 (12.5–25 µM) to abolish AYPGKF-induced Akt phosphorylation, both in wild type and P2Y12 null mouse platelets. We propose that 3.12 µM LY294002 is sufficient to inhibit PI3 kinase isoforms in platelets and higher concentrations might inhibit other pathways regulating Akt phosphorylation by AYPGKF. We conclude that Protease-activated receptor 4 (PAR4) might cause Akt phosphorylation through pathways distinctly different from those of Protease-activated receptor 1 (PAR1).

Photosynthetically available radiation (PAR) reaching the ocean surface controls phytoplankton growth, primary productivity, and evolution within marine ecosystems. Therefore, accurate daily PAR estimates are important for a broad range of marine biology and biogeochemistry applications. In this study, hourly data from Geostationary Ocean Color Imager (GOCI), the world’s first geostationary ocean color sensor, was employed to estimate daily mean PAR at the ocean surface around the Korean Peninsula using a budget model based on plane-parallel theory. In situ PAR data collected from two ocean research stations (Socheong-cho and Ieodo) were used to evaluate the accuracy of the GOCI PAR estimates. First, the instantaneous in situ measurements were checked for calibration and exposure errors against Second Simulation of the Satellite Signal in the Solar Spectrum (6S) radiative transfer calculations under the clearest sky conditions and adjusted to eliminate biases. After adjustment, the root-means-square error (RMSE) between 6S and in situ PAR data was reduced from 6.08 (4.81%) and 3.82 (3.93%) mol/m2/day to 2.85 (2.26%) and 1.74 (1.21%) mol/m2/day at the Socheong-cho and Ieodo stations, respectively, and the coefficient of determination R2 was 0.99. Then, the GOCI daily mean PAR estimated by the initial algorithm were corrected using the 2015 adjusted in situ daily PAR measurements collected under clear-sky conditions. The daily mean PAR values derived from GOCI data in all conditions were improved after the correction, with RMSE reduced from 4.58 (8.30%) to 2.57 (4.65%) mol/m2/day and R2 = 0.97. The comparison statistics were similar for 2015 and 2016 combined, with RMSE of 2.52 (4.38%) and mean bias error (MBE) of –0.40 (–0.70%), indicating that the correction was also effective in cloudy conditions. On the other hand, daily PAR estimates from Moderate Resolution Imaging Spectroradiometer (MODIS) and Advanced Himawari Imager (AHI) yielded larger RMSE of 6.24 (10.40%) mol/m2/day and MBE of –2.49 (–4.15%) mol/m2/day (MODIS) and RMSE of 3.71 (6.51%) mol/m2/day and MBE of –2.65 (–4.65%) mol/m2/day (AHI) against in situ measurements. The GOCI-based daily PAR model developed in this study is reliable and suitable for investigating the marine environment around the Korean Peninsula.

Scotinomys xerampelinus has a restricted distribution in the Cordilleras Central and Talamanca of Costa Rica and western Panama, at an elevational range between 2100 and 3400 m. We report individuals observed at Cerro Chirripó, Costa Rica at 3820 m, which extends upwards the known elevational range by 420 m. The altitudinal range extension may indicate either incomplete surveys in the study area or an upslope shift due to increasing temperatures from climate change, a phenomenon that has forced several Costa Rican vertebrate species to transition to higher elevations.

• Comprehensive testing of the RVK-500 recombiner has been carried out. • For the first time, the rate of hydrogen concentration growth was varied in the tests. • Stable internal combustion without flame escaping externally has been observed. Severe accidents at NPPs with light water coolant can lead to situations when large quantities of hydrogen are released due to zirconium-steam reaction. To avoid explosion consequences, they started to install hydrogen passive autocatalytic recombiners (PARs) at NPPs. Calculating simulation based on PAR models is used to predict and justify the needed quantity of PARs and the chosen place of their location inside the NPP. To validate PAR computational models, experimental data are need. Within the scope of this work, the integrated tests of the RVK-500 type recombiner, which included 20 experiments, were conducted to obtain large body of data on PAR operation in different modes and conditions that can be realized in case of hypothetical accident at NPP. For this purpose, a facility equipped with a measuring set able to work at high pressures, temperatures, and humidity was constructed. The tests were conducted in accord with the predevopled PAR testing procedure and program to describe PAR characteristics, such as its start-up, H 2 recombination rate, efficiency, and ignition limit. In addition, a small-scale facility was used to study the potential of particles separated from the catalytic elements to induce combustion. [ABSTRACT FROM AUTHOR]

One of the most important environmental and safety concerns in nuclear fusion plants is the confinement of radioactive substances into the reactor buildings during both normal operations and accidental conditions. For this reason, hydrogen build-up and subsequent ignition must be avoided, since the pressure and energy generated may threaten the integrity of the confinement structures, causing the dispersion of radioactive and toxic products toward the public environment. Potentially dangerous sources of hydrogen are related to the exothermal oxidation reactions between steam and plasma-facing components or hot dust, which could occur during accidents such as the in-vessel loss of coolant or a wet bypass. The research of technical solutions to avoid the risk of a hydrogen explosion in large fusion power plants is still in progress. In the safety and environment work package of the EUROfusion consortium, activities are ongoing to study solutions to mitigate the hydrogen explosion risk. The main objective is to preclude the occurrence of flammable gas mixtures. One identified solution could deal with the installation of passive autocatalytic recombiners into the atmosphere of the vacuum vessel pressure suppression system tanks. A model to control the PARs recombination capacity as a function of thermal-hydraulic parameters of suppression tanks has been modeled in MELCOR. This paper aims to test the theoretical effectiveness of the PAR intervention during an in-vessel loss of coolant accident without the intervention of the decay heat removal system for the Water-Cooled LithiumLead concept of EU-DEMO.

Rhodolith beds are pervasive marine biological systems in the subarctic North Atlantic. Limited knowledge about effects of temperature and irradiance on rhodolith growth limits the ability to anticipate the response of rhodolith beds to this ocean's chronic low, yet changing sea temperature and irradiance regimes. We carried out a 149‐d laboratory experiment with Newfoundland Lithothamnion glaciale rhodoliths to test the predictions that growth (i) is inhibited at temperatures of ~0.5°C and (ii) resumes as temperature increases above 0.5°C, albeit at a higher rate under high than low irradiances. Rhodoliths were grown in experimental tanks at near‐zero (~0.7°C) seawater temperatures during the first 85 d and at temperatures increasing naturally to ~6°C for the remaining 64 d. Rhodoliths in those tanks were exposed to either low (0.02 mol photons·m−2·d−1) or high (0.78 mol photons·m−2·d−1) irradiances during the entire experiment. Rhodoliths grew at a linear rate of ~281 μm·year−1 (0.77 μm·d−1) throughout the experiment under both irradiance treatments despite daily seawater temperature variation of up to 3°C. Near‐zero temperatures of ~0.5 to 1.0°C did not inhibit rhodolith growth. Model selection showed that PAR‐day (a cumulative irradiance index) was a better predictor of growth variation than Degree‐day (a cumulative thermal index). Our findings extend to ~0.5°C the lower limit of the known temperature range (~1 to at least 16°C) over which growth in L. glaciale rhodoliths remains unaffected, while suggesting that the growth–irradiance relationship in low‐light environments at temperatures below 6°C is less irradiance‐driven than recently proposed. [ABSTRACT FROM AUTHOR]

Field experiments were conducted at Biswanath, Assam, India (26° 42′ N and 93° 15′ E), during 2016, 2017, and 2018, to evaluate the effect of microclimates on growth, yield, and disease incidence in the ginger crop. The ginger variety Nadia was grown under six microclimates, viz., under shade net for the entire crop season (T1), under shade net from planting to mid-October (T2), with pigeon pea (T3), with maize (T4), with okra (T5), and as a sole crop (T6) in three replicated RBD. Photosynthetically active radiation (PAR), net radiation (Rn), temperature above the ginger canopy, soil temperature, and soil moisture were measured during the critical crop growth period under different microclimates. Recording of rhizome rot disease incidence was done periodically and genomic analysis of pathogen was carried out. PAR recorded above the ginger canopy under T6 was 1688.1 μ mol s−1 m−2, which was attenuated up to 80.1% in other microclimates. The Rn load of the ginger canopy was maximum (446.4 W m−2) under T6, which reduced to below 50 W m−2 under both T3 and T4. Both air temperatures above the ginger canopy and soil temperatures under T3 and T4 were reduced by 3.3 °C and 4.6 °C, respectively, as compared to T6. The pathogen causing the disease in the experimental site was identified as Fusarium oxysporum. Considerable increase in soil and air temperature and soil moisture favored disease incidence (90.3%) under shade net (T1 and T2) treatments, while opposite reason causing significant reduction in disease incidence (16.1%) was observed under T3 and T4. More yield of ginger recorded in treatments T3 (6.21 t ha−1) or T4 (6.48 t ha−1) was attributed to better crop growth and diminutive disease incidence, while the crop was almost damaged due to severe disease incidence under shade net (T1 and T2) treatments. [ABSTRACT FROM AUTHOR]

A greenhouse covering film is an essential part of any greenhouse. Its function is to filter solar radiation in the ultraviolet (UV) and the near-infrared (NIR) bands while allowing a great amount of photosynthetically active radiation (PAR) to transmit. This paper proposes a design of the greenhouse covering film based on a frequency selective surface (FSS). Aluminum is made into fibers in the nanoscale. They are laid out in an array, in-plane at equidistance from one another. This arrangement induces the wavelength selectivity of light via adjustment to the fiber sizes and spacings. The performance is evaluated by a finite element analysis (FEA) method. The results show less than 26% transmittance of UV and NIR while allowing more than 94% transmittance in the PAR regime. [ABSTRACT FROM AUTHOR]

U povodu 30. godišnjice donošenja Ustava RH (22.12.1990. – 22.12.2020.) polazimo od teze da je u RH podrazvijena politička kultura koja doprinosi nekvalitetnom djelovanju ustavne demokracije u našoj državi. S obzirom na poznatu poveznicu između građanske i ustavne pismenosti, gdje je druga temeljni sastojak prve, razvili smo opći mjerni okvir ustavne pismenosti i proveli istraživanje ustavne pismenosti najobrazovanijih građana grada Rijeke. Uzorak čini 44 % (N=561) od ukupnog broja nastavnika Sveučilišta u Rijeci, Veleučilišta u Rijeci i Poslovne akademije Rijeka. Analiza rezultata dovodi do sljedećih zaključka. Postoji značajni interes za poznavanje sadržaja, djelovanja i tumačenje našeg Ustava. Postojeće se znanje, međutim, ponajprije zadržava na razini osnova i općih znanja uz vrlo zabrinjavajuće nepoznavanje ustavnih refleksija na svakodnevni život društvene zajednice, kao i recentnu stvarnost. Eklatantni su primjeri sljedeći: preko 46 % ispitanika ne zna kako se formira vlada RH (koja je većina potrebna za osvajanje vlasti), preko 42 % ne zna da je održan referendum o braku i 70 % ispitanika ne zna da pravo EU-a ima primat pred pravom svake države članice, pa tako i RH. Istodobno i ohrabrujuće, utvrđena je i odgovarajuća razina samokritičnosti kroz korektnu procjenu vlastitog (ne)poznavanja Ustava RH, kao i relevantna samoinicijativna spremnost na (online) edukacije o toj tematici.

This action research assignment invites students to participate in the progress of the UN’s Sustainable Development Goal #6 (SDG6) by contributing knowledge to two distinct public discourse communities: Wikipedia: The Free Encyclopedia and Consilience: The Journal of Sustainable Development. SDG6 targets access to clean water and sanitation for all by the year 2030. But, in order to accomplish this, the rate of progress must accelerate dramatically. In small groups, students research an SDG6-related topic and improve a Wikipedia article to make it neutral, balanced, and organized in accordance with Wikipedia quality assessment standards. Simultaneously, students compose an opinion paper addressing SDG6 goals and targeting the cross-disciplinary audience of Consilience: A Journal of Sustainable Development. The project raises awareness of discourse communities while students make headway on SDG6 by publicly sharing their research. The assignment is adaptable to an extensive range of subject matter suitable in both face-to-face and online teaching platforms. Students reflect on their own connections and learn to empathize with others by analyzing how lack of access to potable water and sanitation causes suffering. Action research calls on students, thinking as global citizens, to be bold in creating a new and better world—a world where access to clean water and sanitation brings justice to all.

The natural environment of phytoplankton is variable in manifold ways. Light, as essential resource for photosynthetic phytoplankton, fluctuates in its intensity (quantity) as well as spectrum (quality) over great temporal scales in aquatic ecosystems. To elucidate the significance of temporal heterogeneity in available light spectrum for phytoplankton, we analyzed the growth of four marine North Sea species (chlorophyte Tetraselmis sp., cryptophyte Rhodomonas salina, cyanobacteria Pseudanabaena sp., raphidophyte Fibrocapsa japonica), in monoculture as well as the dynamics of these species in pairwise competition experiments under blue and green light. These species were chosen as they differ in their absorption of light, the colors were chosen to contrast the absorption by chlorophylls (blue), carotenoids (partially green) and phycobiliproteins (green). Light colors were either supplied constantly or along a gradient of fluctuation frequencies (hourly to weekly alternation) between blue and green but always with the same photon flux density. When constantly supplied (no change in color), the color of light led to significant differences in growth rates and carrying capacities of the species, with Pseudanabaena sp. being the only one profiting from green light. Under alternating light color, the maximum growth rate of R. salina was higher with faster light color fluctuations, but lower for Pseudanabaena sp. and did not show significant trends for F. japonica and Tetraselmis sp. Accordingly, competition was significantly affected by the light color treatments, under constant as well as fluctuating supply conditions. However, we did not detect considerable changes in competitive outcomes between fluctuating light colors vs. constant light color supply. As the underwater light in natural ecosystems is rather variable than constant, our results of fluctuations within the light spectrum highlight their frequency-dependent effects on growth and competition. While fluctuating light colors affect the growth and capacity of species, our tested fluctuations did not have major effects on species competition.

Poly (ADP-ribose) polymerase 1 (PARP1) protein is encoded by the PARP1 gene located on chromosome 1 (1q42.12) in human cells. It plays a crucial role in post-translational modification by adding poly (ADP-ribose) (PAR) groups to various proteins and PARP1 itself by utilizing nicotinamide adenine dinucleotide (NAD +) as a substrate. Since the discovery of PARP1, its role in DNA repair and cell death has been its identity. This is evident from an overwhelmingly high number of scientific reports in this regard. However, PARP1 also plays critical roles in inflammation, metabolism, tumor development and progression, chromatin modification and transcription, mRNA stability, and alternative splicing. In the present study, we attempted to compile all the scattered scientific information about this molecule, including the structure and multifunctional role of PARP1 in cancer and non-cancer diseases, along with PARP1 inhibitors (PARPis). Furthermore, for the first time, we have classified PARP1-mediated cell death for ease of understanding its role in cell death pathways. [ABSTRACT FROM AUTHOR]

Recovery of ecosystem properties following removal of invasive plants likely varies with characteristics of the plant and the relative soil quality at a given site. These factors may influence the occurrence of soil legacies and secondary invasions, hindering the effectiveness of restoration strategies. We assessed the potential for ecosystem recovery following removal of N-fixing Scotch broom for 4 years at two sites that contrasted strongly in soil quality in western Washington and Oregon, USA. Comparisons were made among plots, where Scotch broom was never present (uninvaded), retained, or removed. Scotch broom removal increased PAR and soil temperature but had limited effects on soil moisture. Concentrations of soil Ca, Mg, K, and P were significantly lower with Scotch broom removal, with the effect being most pronounced at the low-quality site. NMS ordinations indicated that the treatments differed in vegetation composition, with limited recovery following broom removal. Non-native and native species varied inversely in their abundance responses, where non-native species abundance was greatest in the removal treatment, intermediate in the retained treatment, and lowest in the uninvaded treatment, indicating occurrence of a secondary invasion following removal. As with the soil response, effects were more pronounced at the low-quality site. Our findings indicate that Scotch broom removal exacerbates negative effects on soil chemistry and plant communities, with little evidence of recovery over our study period. These findings highlight the importance of controlling Scotch broom invasions immediately after the species establishes, especially on low-quality sites that are more susceptible to Scotch broom invasion. [ABSTRACT FROM AUTHOR]

Adversity early in life can shape the reproductive potential of individuals through negative effects on health and life span. However, long‐lived populations with multiple reproductive events may present alternative life history strategies to optimize reproductive schedules and compensate for shorter life spans. Here, we quantify the effects of major hurricanes and density dependence as sources of early‐life ecological adversity on Cayo Santiago rhesus macaque female reproduction and decompose their effects onto the mean age‐specific fertility, reproductive pace, and lifetime reproductive success (LRS). Females experiencing major hurricanes exhibit a delayed reproductive debut but maintain the pace of reproduction past debut and show a higher mean fertility during prime reproductive ages, relative to unaffected females. Increasing density at birth is associated to a decrease in mean fertility and reproductive pace, but such association is absent at intermediate densities. When combined, our study reveals that hurricanes early in life predict a delay‐overshoot pattern in mean age‐specific fertility that supports the maintenance of LRS. In contrast to predictive adaptive response models of accelerated reproduction, this long‐lived population presents a novel reproductive strategy where females who experience major natural disasters early in life ultimately overcome their initial reproductive penalty with no major negative fitness outcomes. Density presents a more complex relation with reproduction that suggests females experiencing a population regulated at intermediate densities early in life will escape density dependence and show optimized reproductive schedules. Our results support hypotheses about life history trade‐offs in which adversity‐affected females ensure their future reproductive potential by allocating more energy to growth or maintenance processes at younger adult ages. [ABSTRACT FROM AUTHOR]

The attenuation coefficients of photosynthetically active radiation (PAR) were extracted from the vertical profiles of PAR in coastal waters (the Gulf of Trieste, Northern Adriatic). The vertical profiles were collected roughly twice per month from July 2011 to December 2015, and the PAR values just above the sea surface were compared with the PAR data measured on a buoy. This research supports the nonlinear fit with the biexponential expression for the dependence of PAR with depth, yielding a much better match with the data than the fit with a mono-exponential expression. However, another reasoning for biexponential attenuation is because it functions as a solution for a homogeneous differential equation of a second order. The method for estimating the water type is offered with an analysis of the attenuation coefficients of PAR. It was found that for a particular location (the Gulf of Trieste), the attenuation coefficient in a mono-exponential decrease of PAR is 0.19-0.21 m-1, while for a biexponential decrease of PAR, the coefficient of the long-range attenuation is 0.12-0.14 m-1 and that of short-range attenuation is 0.8-0.9 m-1. This leads to the conclusion that most water columns match coastal water type 1, while the surface layer is represented by coastal water types 7 or 9. From the estimate of the water types, the coefficients of downward irradiation were inferred as 0.19 m-1 ± 0.01 m-1 (long-range attenuation) and 3.0 m-1 ± 0.7 m-1 (short-range attenuation). These coefficients can deter-mine the heat source inside the water column. [ABSTRACT FROM AUTHOR]

Copyright of COMU Journal of Agriculture Faculty / ÇOMÜ Ziraat Fakültesi Dergisi is the property of Canakkale Onsekiz Mart University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Field-measured forest productivity and its time series are crucial to understanding the impact of climate change on the main tree species increment and stand productivity in general. In this study, the causative relationships between environmental factors, such as O3 fluxes and tree ring width formation, including stem sap flow intensity, in the prevalent Lithuanian tree species (Picea abies (L.) Karst, Pinus sylvestris L., Betula pendula, and Betula pubescens) growing under different nutritional and moisture conditions in northeastern Lithuania were examined. We hope that this information will help us assess a trees capacity to adapt to and mitigate recent global clima te changes. Continuous monitoring of the tree stem increment from annual to hourly scales was crucial for this study. The obtained data revealed that Norway spruce trees are appropriately adapted to current climatic conditions in temperate forests. Even during a drought episode, spruce stem increment exceeded the increment of the rest of the studied tree species; therefore, they had the highest water use efficiency compared to the rest of the tree species in the study. O3 fluxed through the stomata at an hourly scale, stimulating the stem shrinking process more intensively than inhibiting the swelling process, but only for pine and birch trees. Spruce trees demonstrated the highest sensitivity to O3 because O3 significantly affected the stem swelling process. Pine trees were less sensitive to O3 damage, and birch trees were the least affected. Reduced tree growth intensity and the weak relationship between birch tree radial increment and the main meteorological parameters indicate that birch trees have the lowest adaptive capacity to recent environmental changes of the tree species in this study. [ABSTRACT FROM AUTHOR]

Poly (ADP-ribose) polymerase 1 (PARP1) protein is encoded by the PARP1 gene located on chromosome 1 (1q42.12) in human cells. It plays a crucial role in post-translational modification by adding poly (ADP-ribose) (PAR) groups to various proteins and PARP1 itself by utilizing nicotinamide adenine dinucleotide (NAD +) as a substrate. Since the discovery of PARP1, its role in DNA repair and cell death has been its identity. This is evident from an overwhelmingly high number of scientific reports in this regard. However, PARP1 also plays critical roles in inflammation, metabolism, tumor development and progression, chromatin modification and transcription, mRNA stability, and alternative splicing. In the present study, we attempted to compile all the scattered scientific information about this molecule, including the structure and multifunctional role of PARP1 in cancer and non-cancer diseases, along with PARP1 inhibitors (PARPis). Furthermore, for the first time, we have classified PARP1-mediated cell death for ease of understanding its role in cell death pathways. [ABSTRACT FROM AUTHOR]

Komunitas penyandang cacat, khususnya komunitas tunarungu di Bandar Lampung jumlahnya cukup banyak, yaitu 114 orang. Komunitas ini masih membutuhkan perhatian dari berbagai lapisan masyarakat agar mereka memiliki keterampilan untuk hidup mandiri. Telur adalah salah satu makanan yang dikonsumsi oleh banyak orang Indonesia. Sekitar 10% bagian dari telur adalah cangkang. Provinsi Lampung, khususnya Kota Bandar Lampung berpotensi untuk menghasilkan limbah kulit telur. Setiap hari, sekitar 24.700 kg telur digunakan di Bandar Lampung dengan potensi kulit telur mencapai 2.470 kg. Oleh karena itu, limbah cangkang telur bisa dimanfaatkan oleh komunitas tunarungu untuk fortifikasi berbagai penganan sehingga memiliki nilai tawar yang berbeda dengan produk sejenis. Strategi penerapan kegiatan pengabdian ini menggunakan empat tahapan, yaitu persiapan, implementasi, pelatihan, dan pemantauan. Kegiatan pemberdayaan yang dilaksanakan oleh tim pengabdi dari Universitas Islam Negeri Raden Intan Lampung dalam mengolah limbah cangkang telur sebagai bahan yang difortifikasi ke berbagai penganan dirasakan memberikan manfaat bagi komunitas tunarungu di Kota Bandar Lampung karena mereka dapat berwirausaha.

Replicated temperature data from passively heated high tunnels are lacking, especially in the southwestern United States. Field studies were conducted over three seasons in two locations in New Mexico—a southern site in Las Cruces and a northern site in Alcalde—to characterize the crop environment in three high-tunnel designs during the winter growing season (October–March). High tunnels were 16 × 32 ft and oriented with the long edge running east to west. Heavyweight woven plastic covered the single-layer (SL) high-tunnel design. Double-layer designs (DL) were covered with a lightweight woven plastic on the bottom, followed by a second layer of the heavyweight plastic inflated with a fan. A heat sink was created using 16 55-gal barrels painted black, filled with water, and aligned along the north side of the double layer for the DL+B design. Soil temperature (3 inches deep) and air temperature (1 ft above the soil surface) were recorded inside the high tunnel, inside the high tunnel under a floating rowcover, and outside the high tunnel. In addition, photosynthetically active radiation (PAR) was recorded inside and outside the high tunnels during or near the winter solstice each year of the study. Daily air and soil temperature minimums were highest in the DL+B design and lowest in the SL design. Maximum air and soil temperatures did not significantly differ between high-tunnel designs, although the DL+B design measurements were consistently lower. During season 1, the SL design had significantly higher PAR transmission than the other two designs. In the northern location, the difference became insignificant during seasons 2 and 3, likely due to dust accumulation and plastic aging. In the southern location, the SL design maintained higher PAR transmission throughout the study, possibly due to plastic cleaning. Data collected in this study can help inform the decisions of high-tunnel growers and researchers in the region.

Local energy generation and peer to peer (P2P) energy trading in the local market can reduce the energy consumption cost, emission of harmful gases (as renewable energy sources are used to generate energy at user's premises) and increase the smart grid resilience. However, local energy trading with peers can have trust and privacy issues. A centralized system can be used to manage this energy trading but it increases the overall cost of the system and also faces several issues. In this paper, to implement a hybrid P2P energy trading market, a blockchain-based system is proposed. It is fully decentralized and allows the market members to interact with each other and trade energy without involving a third party. Smart contracts play a very important role in the blockchain-based energy trading market. They contain all the necessary rules for energy trading. We have proposed three smart contracts to implement the hybrid electricity trading market. The market members interact with the main smart contract, which requests P2P and prosumer to grid smart contracts for further processing. The main objectives of this paper are to propose a model to implement an efficient hybrid energy trading market while reducing cost and peak to average ratio of electricity.

Aim. To reveal the basic patterns and principles of formation on the surface of crusty solonchak of an aeolian-accumulative horizon and its positive transformation at the taxonomic level.Material and Methods. On the surface of crusty solonchak there is formed a layer of silt-sand fractions with seeds of wild phytocenoses which move/перемещаюихся over the surface of the soil under the influence of atmospheric processes with the utilization of woody material protruding above the soil surface to 0.2 m. Analyses, surveys and observations were carried out of the key parts (for investigation - under the aeolian layer) of the crusty solonchak transformed through the dynamics of humidity, lowering of soil moisture (SC), granulometric composition, chemistry and level of soil salinity, as well as determination of the species composition of the phytocenoses and the accumulation of phytomass by plants.Results. The possibility was revealed of a positive transformation within eight years of a layer of silt-sand fractions with seeds of wild phytocenoses in the Wael humus horizon with a capacity of 5 cm ± 0.8 cm and containing 1.26% of humus. The type of salinization remains sulphate-chloride but the level of salinization decreases from very strong in the 0-5 layer to weak one in the 6-15 cm layer - on average. The profile of the crusty solonchak Скк [AJk - AJ,s - BCA,s - Cca,s] is changed to that of regraded solonchak Ckw [Wael - AJ,s - BCA,s - Cca,s]. The granulometric composition of the soil is improved and a productive phytocenosis is formed.Conclusion. The positive transformation of crusty solonchak to regraded contributes to the reduction of soil deflation and of aerial contamination by dust particle fractions, the lowering of carbon emissions from the soil and of the natural greenhouse effect, the increase of the utilization coefficient of photosynthetically active radiation (PAR) and the prevention of excessive overheating of the soil and atmosphere.

Abstract Adversity early in life can shape the reproductive potential of individuals through negative effects on health and life span. However, long‐lived populations with multiple reproductive events may present alternative life history strategies to optimize reproductive schedules and compensate for shorter life spans. Here, we quantify the effects of major hurricanes and density dependence as sources of early‐life ecological adversity on Cayo Santiago rhesus macaque female reproduction and decompose their effects onto the mean age‐specific fertility, reproductive pace, and lifetime reproductive success (LRS). Females experiencing major hurricanes exhibit a delayed reproductive debut but maintain the pace of reproduction past debut and show a higher mean fertility during prime reproductive ages, relative to unaffected females. Increasing density at birth is associated to a decrease in mean fertility and reproductive pace, but such association is absent at intermediate densities. When combined, our study reveals that hurricanes early in life predict a delay‐overshoot pattern in mean age‐specific fertility that supports the maintenance of LRS. In contrast to predictive adaptive response models of accelerated reproduction, this long‐lived population presents a novel reproductive strategy where females who experience major natural disasters early in life ultimately overcome their initial reproductive penalty with no major negative fitness outcomes. Density presents a more complex relation with reproduction that suggests females experiencing a population regulated at intermediate densities early in life will escape density dependence and show optimized reproductive schedules. Our results support hypotheses about life history trade‐offs in which adversity‐affected females ensure their future reproductive potential by allocating more energy to growth or maintenance processes at younger adult ages.

Due to the difficulties in natural regeneration of black pine (Pinus nigra Arnold) forests, the influences of different stand structural parameters on regeneration success should be well understood. Canopy closure is one of the most commonly used parameters in natural regeneration activities in Turkey. However, studies regarding the effects of stand basal area (GYA) (m2/ha), stand stocking (%) and light transmittance (GIM) (%) on black pine regeneration has been limited. In this study, we aimed to determine the influences of GYA, stand stocking and GIM on seedling density, as well as root-collar diameter (KBÇ) and height of 5-year old black pine seedlings. We also aimed to find which parameter has more influence on black pine seedlings. GYA for each study plot installed within Kastamonu Araç Forest Planning Unit was calculated, and GIM of each plot was also determined using a Plant Canopy Imager. Stand stocking of each plot was calculated using a published equation. There were significant relationships between stand parameters and seedling density, KBÇ and seedling height (p

Aceh Tamiang is an area with a majority Muslim population, not even one in Adil Makmur Village, Tenggulun, which is the location for this activity to find other places of worship besides mosques and prayer rooms. However, there is a decline in the quality of reading and writing the Koran in today's young generation compared to previous generations. This is due to the lack of parental attention to the quality of children's reading of the Koran, because they have fully surrendered this role to existing Koranic educational institutions. While in the previous generation, most parents were very disciplined for matters related to religious knowledge, especially reading and writing the Koran. The implementation of this Action Research aims to improve the literacy and writing skills of the young generation of the Koran in Adil Makmur Village, Tenggulun, Aceh Tamiang by empowering STAI As-sunnah students for Tahsin al-Qiraah activities. The method used is Participatory Action Research. By doing 3 stages: Planning-Action-Evaluation. The result of this activity: increased public enthusiasm for the importance of the younger generation having the ability to read and write the Koran in Adil Makmur Village, Tenggulun, Aceh Tamiang. In addition, this activity has also succeeded in making the role of parents as the main guides for children re-enforced

Adprhl2 (OMIM: 610624) mutation associated stress-induced childhood-onset neurodegeneration with variable ataxia and seizures (CONDSIAS, OMIM: 618170) is a sporadic neurodegenerative disease with poor prognosis. ADPRHL2 encodes ADP-ribosylhydrolase 3 (ARH3), which participates in ADP-ribosylation to remove poly-ADP ribose (PAR). We found a new compound heterozygous mutation in the ADPRHL2 gene c.580C > T (p.Gln194Ter) and c.803-1G > A in a 30-month-old boy, who showed gait instability, abnormal EEG, and developmental delay after respiratory infection. He died of convulsions 4 months after onset. By constructing a mutant plasmid and using Western blot to detect the expression of ARH3 and PAR, it was demonstrated that the ADPRHL2 gene c.580C > T (p.Gln194Ter) and c.803-1G > A is pathogenic according to ACMG guidelines., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Dan Sun reports financial support was provided by Wuhan Knowledge innovation special project. Dan Sun reports financial support was provided by the Key research and development program of Hubei Province. Dan Sun reports financial support was provided by Construction Project of Hubei Provincial Clinical Medical Research Center for Childhood Neurodevelopmental Disorders. Dan Sun reports financial support was provided by 10.13039/501100020487Nature Science Foundation of Hubei Province. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Despite the numerous advances towards the recognition of LGBT rights worldwide, real equity has not yet been achieved. It is therefore necessary to take into consideration not only the socio‐political context but also the concrete practices that have been developed in specific settings. The university represents an important scene, which generates knowledge and development in societies. This study, from a Liberating Community Psychology approach, analysed five good practices related to LGBT issues and psychology placed in four countries with different socio‐cultural backgrounds: Brazil, Uruguay, Colombia and Spain. The results from an ecological SWOT analysis—based on interviews and questionnaires with diverse stakeholders and experts—showed the internal weaknesses (e.g., lack of resources) and strengths (e.g., high promoters' commitment, students acceptance) of the good practices, as well as their external opportunities and threats in the academic (e.g., social status of the university, curricula gaps), but also in the socio‐political context (e.g., protecting policies, attacks from conservative sectors). Additionally, action‐research proposals to improve equity in/from universities were suggested by stakeholders and prioritized by experts through a Delphi panel. The main theoretical and practical contributions are discussed. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement. [ABSTRACT FROM AUTHOR]