416 results on '"luigi mansi"'
Search Results
102. Risk-related 18F-FDG PET/CT and new diagnostic strategies in patients with solitary pulmonary nodule: the ITALIAN multicenter trial
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Alberto Cuocolo, Laura Evangelista, Stefano Fanti, Silvana Del Vecchio, Orazio Schillaci, Emanuele Nicolai, Luca Guerra, Paolo Miletto, Luigi Mansi, Giorgio Saladini, M. Ferdeghini, Francesco Del Prete, Giovanni Storto, Mohsen Farsad, Cesare Gridelli, Marco Spadafora, Giuseppina Peluso, Alessandro Giordano, Leonardo Pace, Giovanna Pepe, Spadafora, Marco, Pace, Leonardo, Evangelista, Laura, Mansi, Luigi, Del Prete, Francesco, Saladini, Giorgio, Miletto, Paolo, Fanti, Stefano, Del Vecchio, Silvana, Guerra, Luca, Pepe, Giovanna, Peluso, Giuseppina, Nicolai, Emanuele, Storto, Giovanni, Ferdeghini, Marco, Giordano, Alessandro, Farsad, Mohsen, Schillaci, Orazio, Gridelli, Cesare, Cuocolo, Alberto, Spadafora M, Pace L, Evangelista L, Mansi L, Del Prete F, Saladini G, Miletto P, Fanti S, Del Vecchio S, Guerra L, Pepe G, Peluso G, Nicolai E, Storto G, Ferdeghini M, Giordano A, Farsad M, Schillaci O, Gridelli C, Cuocolo A., Spadafora, M, Pace, L, Evangelista, L, Mansi, L, Del Prete, F, Saladini, G, Miletto, P, Fanti, S, Del Vecchio, S, Guerra, L, Pepe, G, Peluso, G, Nicolai, E, Storto, G, Ferdeghini, M, Giordano, A, Farsad, M, Schillaci, O, Gridelli, C, and Cuocolo, A more...
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Male ,Risk ,medicine.medical_specialty ,Settore MED/10 - Malattie dell'Apparato Respiratorio ,Whole body imaging ,Population ,Pulmonary nodule,18F-fluorodeoxyglucose, Segmental-PET/CT, Extra-thoracic lesions ,F-fluorodeoxyglucose ,Malignancy ,Pulmonary nodule ,030218 nuclear medicine & medical imaging ,Segmental-PET/CT ,03 medical and health sciences ,0302 clinical medicine ,Settore MED/36 - Diagnostica per Immagini e Radioterapia ,Fluorodeoxyglucose F18 ,18F-fluorodeoxyglucose ,Extra-thoracic lesions ,Aged ,Female ,Humans ,Italy ,Solitary Pulmonary Nodule ,Positron Emission Tomography Computed Tomography ,Multicenter trial ,Medical imaging ,medicine ,Radiology, Nuclear Medicine and imaging ,Risk factor ,education ,Solitary pulmonary nodule ,education.field_of_study ,business.industry ,General Medicine ,medicine.disease ,Pre- and post-test probability ,Extra-thoracic lesion ,030220 oncology & carcinogenesis ,Radiology ,business ,Human - Abstract
PURPOSE: Diagnosis of solitary pulmonary nodule (SPN) is an important public health issue and 18F-FDG PET/CT has proven to be more effective than CT alone. Pre-test risk stratification and clinical presentation of SPN could affect the diagnostic strategy. A relevant issue is whether thoracic segmental (s)-PET/CT could be implemented in patients with SPN. This retrospective multicenter study compared the results of FDG whole-body (wb)-PET/CT to those of s-PET/CT. METHODS: 18F-FDG PET/CT of 502 patients, stratified for pre-test cancer risk, were retrospectively analyzed. The thoracic part of wb-PET/CT, considered s-PET/CT, was compared to wb-PET/CT. Clinical and PET/CT variables were investigated for SPN characterization as well as for identification of patients in whom s-PET/CT could be performed. Histopathology or follow-up data were used as a reference. RESULTS: In the study population, 36% had malignant, 35% benign, and 29% indeterminate SPN. 18F-FDG uptake indicative of thoracic and extra-thoracic lesions was detectable in 13% and 3% of the patients. All patients with extra-thoracic metastases (n = 13) had thoracic lymph node involvement and highest 18F-FDG uptake at level of SPN (negative predictive value 100%). Compared to wb-PET/CT, s-PET/CT could save about 2/3 of 18F-FDG dose, radiation exposure or scan-time, without affecting the clinical impact of PET/CT. CONCLUSION: Pre-test probability of malignancy can guide the diagnostic strategy of 18FDG-PET/CT in patients with SPN. In subjects with low-intermediate pretest probability s-PET/CT imaging might be planned in advance, while in those at high risk and with thoracic lymph node involvement a wb-PET/CT is necessary. more...
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- 2018
103. Malignancies of Lower Gastroenterological Tract
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Mohsen Farsad, Paolo Castellucci, Luigi Mansi, and Stefano Fanti
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medicine.medical_specialty ,Colorectal cancer ,business.industry ,medicine.medical_treatment ,Disease ,medicine.disease ,Polypectomy ,Basal (phylogenetics) ,medicine.anatomical_structure ,Ct examination ,medicine ,False positive paradox ,In patient ,Radiology ,business ,Lymph node - Abstract
18F-FDG PET/CT has a limited use in detecting primary colorectal cancer. False-negative results may be present in small tumors or in mucinous lesions [1–3], while false positives have been observed in patients with Inflammatory Bowel Diseases (IBD) or previous diagnostic polypectomy [1]. With 18F FDG-PET being more accurate than CT in detecting lymph node metastases, conversely CT is more sensitive for liver metastases. Because of the high incidence of disease recurrence (30–40%), an integrated PET/CT examination, also using contrast media, may be requested in selected patients with a high probability of distant secondarisms. Furthermore, because FDG’s uptake is expression of tumor aggressiveness, PET/CT pre-therapeutic utilization is also suggested as a prognostic tool; similarly, it is important to acquire a basal study, when it is supposed to utilize FDG to evaluate therapeutic response in follow-up [4]. Nevertheless, in the preoperative initial staging of disease, 18F-FDG PET/CT is considered potentially useful, although not yet sufficiently validated as first-line procedure [5]. more...
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- 2018
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104. Italian Tailored Assessment of Lung Indeterminate Accidental Nodule by Proposing a Segmental PET/Computed Tomography (s-PET/CT): Rationale and Study Design of a Retrospective, Multicenter Trial
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Alberto Cuocolo, Laura Evangelista, Leonardo Pace, Luigi Mansi, Marco Spadafora, Evangelista, Laura, Spadafora, Marco, Pace, Leonardo, Mansi, Luigi, and Cuocolo, Alberto
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Male ,Lung Neoplasms ,Standardized uptake value ,Computed tomography ,SPN ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Single pulmonary nodule, diagnostic performance, FDG PET/CT, radiobiology, cost-analysis, SUV, SPN ,diagnostic performance ,Fluorodeoxyglucose F18 ,Multicenter trial ,Positron Emission Tomography Computed Tomography ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Whole Body Imaging ,Aged ,Retrospective Studies ,cost-analysis ,Pharmacology ,Single pulmonary nodule ,PET-CT ,Lung ,medicine.diagnostic_test ,business.industry ,Solitary Pulmonary Nodule ,Nodule (medicine) ,FDG PET/CT ,SUV ,medicine.anatomical_structure ,Italy ,radiobiology ,Positron emission tomography ,Research Design ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,Radiopharmaceuticals ,business ,Indeterminate ,Nuclear medicine ,cost-analysi - Abstract
Background The Italian Tailored Assessment of Lung Indeterminate Accidental Nodule (ITALIAN) is a retrospective, multicenter trial designed to compare the diagnostic information provided by segmental positron emission tomography (PET)/computed tomography (CT) (s-PET/CT) with those of whole body (wb)-PET/CT in patients with single pulmonary nodules (SPN). This report describes the details and implications of the ITALIAN trial design. Methods and results Between September 2016 and May 2017, 502 consecutive patients (302 men, mean age 67±12 years) with SPN undergoing 18F-fluorodeoxyglucose (FDG) PET/CT were enrolled. PET/CT images will be visually and semiquantitatively evaluated. For visual analysis, a 4-point scoring system (1=absent; 2=mild; 3=moderate and 4=intense) will be used; for semiquantitative analysis, maximum standardized uptake value (SUV) in the SPN and mean SUV in the mediastinal blood pool and in the liver will be computed. Conclusion The results of this trial might help to define the role of s-PET/CT in patients with SPN. This trial will also evaluate the impact on radiobiology and costs subsequent the introduction of this alternative imaging acquisition modality. more...
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- 2018
105. Urological Malignancies
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Stefano Fanti, Mohsen Farsad, Luigi Mansi, and Paolo Castellucci
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- 2018
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106. Head and Neck Malignancies
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Stefano Fanti, Mohsen Farsad, Paolo Castellucci, and Luigi Mansi
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medicine.medical_specialty ,Heterogeneous group ,medicine.diagnostic_test ,business.industry ,Physical examination ,The primary diagnosis ,Therapy response ,medicine ,Panendoscopy ,Medical history ,Basal cell ,Radiology ,Head and neck ,business - Abstract
Head and neck cancers account for about 5% of all the malignant diseases [1] and the majority of them are squamous cell carcinoma. In this heterogeneous group of pathologies the primary diagnosis is usually made by patient history, physical examination, and panendoscopy with directed biopsies. However imaging is crucial as it can help significantly clinicians in the (1) detection, (2) staging, (3) restaging, (4) therapy response assessment, and (5) monitoring of patients during follow-up. more...
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- 2018
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107. Malignancies in Hematology
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Mohsen Farsad, Luigi Mansi, Stefano Fanti, and Paolo Castellucci
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medicine.medical_specialty ,Hematology ,medicine.diagnostic_test ,business.industry ,Computed tomography ,medicine.disease ,Lymphoma ,medicine.anatomical_structure ,immune system diseases ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Tomography ,Radiology ,Bone marrow ,Metabolic activity ,business - Abstract
Positron-emission tomography with computed tomography (PET/CT) using 18F-FDG is the imaging of choice in lymphomas [1]. Almost all subtypes of lymphoma (with the exception of some low-grade NHL) show high metabolic activity and that condition makes the staging of the disease very accurate either in the detection of nodal, extranodal, or bone marrow involvement [2]. more...
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- 2018
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108. Thoracic Malignancies
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Stefano Fanti, Mohsen Farsad, Luigi Mansi, and Paolo Castellucci
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- 2018
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109. Duccio Volterrani, Paola Anna Erba, Ignasi Carrió, H. William Strauss, Giuliano Mariani. Nuclear Medicine Textbook Methodology and Clinical Application, 2 Volumes. Springer Nature Switzerland AG 2019, ISBN 978-3-319-95563-6
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Luigi Mansi
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media_common.quotation_subject ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Art ,Humanities ,media_common - Published
- 2019
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110. Galderisi Silvana, DeLisi Lynn E., Borgwardt Stefan (Eds.). Neuroimaging of Schizophrenia and Other Primary Psychotic Disorders. Achievements and Perspectives
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Luigi Mansi
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medicine.medical_specialty ,Neuroimaging ,Schizophrenia (object-oriented programming) ,medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Psychiatry ,Psychology - Published
- 2019
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111. Andrei Iagaru, Thomas Hope, Patrick Veit-Haibach (Eds): PET/MRI in Oncology. Current Clinical Applications
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Luigi Mansi
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medicine.medical_specialty ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,General Medicine ,business - Published
- 2019
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112. Eugene C. Lin and Abass Alavi (Eds): PET and PET/CT. A Clinical Guide. Third Edition
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Luigi Mansi
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PET-CT ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business ,Nuclear medicine - Published
- 2019
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113. Atlas of PET-CT : A Quick Guide to Image Interpretation
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Stefano Fanti, Mohsen Farsad, Luigi Mansi, Paolo Castellucci, Stefano Fanti, Mohsen Farsad, Luigi Mansi, and Paolo Castellucci
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- Tomography, Emission--Case studies, Tomography, Emission--Atlases, Tomography--Atlases
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This new atlas, the fourth of a successful series, is a completely revised and updated edition of a previously published FDG PET-CT atlas. In the past few years, considerable progress has been made in the field of PET-CT imaging, and this new edition takes full account of these recent developments. Furthermore, its educational mission has been broadened: beyond serving as a straightforward guide to FDG PET-CT imaging it now encompasses the integrative use of contrast-enhanced CT and MRI. The new edition also includes non-oncological indications for FDG PET-CT.The atlas aims to help imaging practitioners to recognize physiological and benign pathological FDG uptake and illustrates in a case-based, practical manner the PET-CT appearances of all the major tumors and infectious, inflammatory, and neurodegenerative disorders. The main clinical applications are covered, and learning points and pitfalls are clearly articulated. The consistent, user-friendly format facilitates imageinterpretation and allows rapid review of key information needed for FDG PET-CT imaging. more...
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- 2018
114. Pediatric molecular imaging today: new technologies, new challenges, new answers
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S. Ted Treves, Luigi Mansi, and Diego De Palma
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medicine.medical_specialty ,medicine.diagnostic_test ,Emerging technologies ,business.industry ,Interventional radiology ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Molecular imaging ,business - Published
- 2016
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115. Preliminary Human Radiation Dose Estimates of PET Renal Agents, Para
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Mohsen, Cheki, Maryam, Papie, Luigi, Mansi, Sean, Kitson, and Hariprasad, Gali
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Fluorine Radioisotopes ,Hippurates ,Radiation Dosage ,Renal Agents ,Rats ,Technetium Tc 99m Mertiatide ,Iodine Radioisotopes ,Positron-Emission Tomography ,Animals ,Humans ,Iodohippuric Acid ,Tissue Distribution ,Monte Carlo Method ,Radioisotope Renography - Abstract
Para-18F-fluorohippuric acid (18F-PFH) and ortho-124I-iodohippuric acid (124IOIH) were recently identified as potential radiotracers suitable for conducting renography using positron emission tomography (PET). The aim of this work was to estimate preliminary human-equivalent internal radiation dose of 18F-PFH and 124I-OIH using the biodistribution data reported in healthy rats. The results were compared with the absorbed dose data of technetium-99m-mercaptoacetyltriglycine (99mTc- MAG3) as documented in the International Commission on Radiological Protection (ICRP) publication 80.The medical internal radiation dose (MIRD) formula was applied to extrapolate data from rats to human and to project the absorbed radiation dose for various organs in humans. S factor was calculated by Monte-Carlo N-particle (MCNP) simulation.Our dose prediction shows that an injection of 18F-PFH or 124I-OIH in humans would result in an estimated effective absorbed dose of 0.09 or 0.17 µSv/MBq respectively for whole body, which is about 135 or 73 times respectively lower than that obtained with an injection of 99mTc-MAG3. All organs except kidneys would receive an estimated effective absorbed dose of0.1 µSv/MBq for 18F-PFH or 124I-OIH. Kidneys would receive a dose of 0.83 or 0.77 µSv/MBq respectively for 18F-PFH or 124I-OIH.Our results indicate that 18F-PFH and 124I-OIH would deliver much safer levels and lower radiation doses to the patients compared to 99mTc-MAG3 and warrants a clinical trial to estimate the radiation doses more accurately. more...
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- 2017
116. Editorial Review 2017
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Luigi Mansi and Sean L. Kitson
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Pharmacology ,Text mining ,History ,business.industry ,MEDLINE ,Library science ,Radiology, Nuclear Medicine and imaging ,business - Published
- 2017
117. Clinical characteristics of patient selection and imaging predictors of outcome in solid tumors treated with checkpoint-inhibitors
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Luca Toschi, Angelo Castello, Sabrina Rossi, Egesta Lopci, Luigi Mansi, and Fabio Grizzi
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0301 basic medicine ,Oncology ,medicine.medical_specialty ,medicine.medical_treatment ,Context (language use) ,Antineoplastic Agents ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Neoplasms ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Immune-Related Response Criteria ,Chemotherapy ,business.industry ,Patient Selection ,Immunity ,Cancer ,General Medicine ,Immunotherapy ,medicine.disease ,Clinical trial ,030104 developmental biology ,Treatment Outcome ,030220 oncology & carcinogenesis ,Immunology ,Biomarker (medicine) ,business ,Kidney cancer - Abstract
The rapidly evolving knowledge on tumor immunology and the continuous implementation of immunotherapy in cancer have recently led to the FDA and EMA approval of several checkpoint inhibitors as immunotherapic agents in clinical practice. Anti-CTLA-4, anti-PD-1, and anti-PDL-1 antibodies are becoming standard of care in advanced melanoma, as well as in relapsed or metastatic lung and kidney cancer, demonstrating higher and longer response compared to standard chemotherapy. These encouraging results have fostered the evaluation of these antibodies either alone or in combination with other therapies in several dozen clinical trials for the treatment of multiple tumor types. However, not all patients respond to immune checkpoint inhibitors, hence, specific biomarkers are necessary to guide and monitor therapy. The utility of PD-L1 expression as a biomarker has varied in different clinical trials, but, to date, no consensus has been reached on whether PD-L1 expression is an ideal marker for response and patient selection; approximately 20–25% of patients will respond to immunotherapy with checkpoint inhibitors despite a negative PD-L1 staining. On the other hand, major issues concern the evaluation of objective response in patients treated with immunotherapy. Pure morphological criteria as commonly used in solid tumors (i.e. RECIST) are not sufficient because change in size is not an early and reliable marker of tumor response to biological therapies. Thus, the scientific community has required a continuous adaptation of immune-related response criteria (irRC) to overcome the problem. In this context, metabolic information and antibody-based imaging with positron emission tomography (PET) have been investigated, providing a powerful approach for an optimal stratification of patients at staging and during the evaluation of the response to therapy. In the present review we provide an overview on the clinical characteristics of patient selection when using imaging predictors of outcome in solid tumors treated with checkpoint-inhibitors. more...
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- 2017
118. IAEA Technical Report Series
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Luigi Mansi and Stephen J. Mather
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medicine.medical_specialty ,MEDLINE ,medicine ,Technical report ,Environmental science ,Radiology, Nuclear Medicine and imaging ,Medical physics ,General Medicine - Published
- 2017
119. The natural history of takotsubo syndrome: a two-year follow-up study with myocardial sympathetic and perfusion G-SPECT imaging
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Ignasi Carrió, Francesco Bellandi, Mario Leoncini, Antonio Castagnoli, Francesco Pestelli, Stelvio Sestini, Luigi Mansi, and Christian Mazzeo
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Male ,medicine.medical_specialty ,Cardiomyopathy ,Adrenergic ,Perfusion scanning ,030204 cardiovascular system & hematology ,mIBG ,Contractility ,Ventricular Dysfunction, Left ,03 medical and health sciences ,Myocardial perfusion imaging ,Myocardial perfusion ,0302 clinical medicine ,Takotsubo Cardiomyopathy ,Internal medicine ,Spect imaging ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Longitudinal Studies ,030212 general & internal medicine ,Aged ,Aged, 80 and over ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Myocardial Perfusion Imaging ,Gated Blood-Pool Imaging ,General Medicine ,Middle Aged ,medicine.disease ,Autonomic Nervous System Diseases ,Echocardiography ,Disease Progression ,Cardiology ,Female ,business ,Takotsubo syndrome ,Perfusion ,Stress, Psychological ,Follow-Up Studies - Abstract
To investigate changes in sympathetic activity, perfusion, and left ventricular (LV) functionality in takotsubo cardiomyopathy (TTC) patients from onset (T-0) to post-onset conditions at 1 month (T-1), 1-2 years (T-2, T-3). Twenty-two patients (70 +/- 11 years) underwent serial gated single photon emission tomography (G-SPECT) studies with I-123-mIBG and Tc-99m-Sestamibi. Statistics were performed using ANOVA/Sheff, post-hoc, correlation test, and receiver operating characteristic (ROC) curve analysis (p < 0.05). Patients presented at T-0 with LV ballooning and reduced early-late mIBG uptake (95%, 100%), left ventricular ejection fraction (LVEF)(G-SPECT) (86%) and perfusion (77 %). Adrenergic dysfunction was greater in apex, it overlaps with contractile impairment, and both were more severe than perfusion defect. During follow-up, LVEFG-SPECT, contractility, and perfusion were normal, while 82% and 90% of patients at T-1 and 50% at T-2 and T-3 continued to show a reduced apical early-late mIBG distribution. These patients presented at T-0-T-1 with greater impairment of adrenergic function, contractility, and perfusion. A relationship was present within innervation and both perfusion and contractile parameters at T-0 and T-1, and between the extent of adrenergic defect at T-3 and both the defect extent and age at T-0 (cut-off point 42.5%, 72 years). Outcome for TTC is not limited to a reversible contractile and perfusion abnormalities, but it includes residual adrenergic dysfunction, depending on the level of adrenergic impairment and age of patients at onset. The number of patients, as well as degree of perfusion abnormalities were found to be higher than those previously reported possibly depending on the time-interval between hospital admission and perfusion scan. more...
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- 2017
120. Nuclear medicine in patients with net: Radiolabeled somatostatin analogues and their brothers
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Giuseppe Danilo Di Stasio, Maria Rosaria Prisco, Vincenzo Cuccurullo, Luigi Mansi, Cuccurullo, V, Prisco, M. R., Di Stasio, G. D., and Mansi, L.
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Radiology, Nuclear Medicine and Imaging ,PET/CT ,Diagnostic accuracy ,Octreotide ,Scintigraphy ,Somatostatin analogue ,030218 nuclear medicine & medical imaging ,Dota-peptide ,Lesion ,Octreoscan® ,03 medical and health sciences ,0302 clinical medicine ,Fluorodeoxyglucose F18 ,Positron Emission Tomography Computed Tomography ,Organometallic Compounds ,medicine ,Humans ,In patient ,Pharmacology ,PET-CT ,medicine.diagnostic_test ,business.industry ,18F-DOPA ,Positron emitters ,SPECT/CT ,Response to treatment ,Dihydroxyphenylalanine ,Neuroendocrine Tumors ,Somatostatin ,030220 oncology & carcinogenesis ,Nuclear Medicine ,Radiopharmaceuticals ,medicine.symptom ,Nuclear medicine ,business - Abstract
Although Somastostatin (SS) scintigraphy (SRS) has been introduced many years ago, it remains the most diffuse radionuclide diagnostic tool in patients with neuroendocrine tumours (NETs). Being SS receptors (SSTR) expressed in the majority of NETs, radiolabeled SS analogues (SS-A) provide high diagnostic accuracy, mainly in patients with gastro-entero-pancreatic (GEP) tumors. SSTR are the best target for radiotracers used either for diagnostic and therapeutic purposes in NETs due to their presence on the surface of neoplastic cells of clinical interest. 111In- DTPA-octreotide (111In-Pentetreotide, Octreoscan®), may detect either primitive or secondary lesions in the presence of a satisfactory lesion/background ratio. The unsatisfactory diagnostic performance of 18F-Fluorodeoxyglucose (18F-FDG), in NETs stimulated the synthesis of more specific positron-emitting tracers and SS-A labeled with 68Gallium (DOTA-peptides) represent actually the best radionuclide procedure for NET imaging. Alternative radiotracers, labeled either with gamma or positron emitters and showing different uptake mechanisms, as 18F-DOPA (Fluorine- 18-L-dihydroxyphenylalanine), have also been proposed and clinically utilized. Octreoscan®, despite its limitations, continue to represent the most frequently used method in evaluating the response to treatment and in follow-up of patients with NET, although the better diagnostic accuracy of DOTA-peptides. more...
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- 2017
121. 11C-mHED for PET / CT: Principles of Synthesis, Methodology and First Clinical Applications
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Igor Diemberger, Raffaele La Donna, Cristina Nanni, Rachele Bonfiglioli, Gianmario Sambuceti, Cinzia Pettinato, Stefano Fanti, Giuseppe Boriani, Luigi Mansi, Lucia Zanoni, and Cristian Martignani
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Pharmacology ,PET-CT ,medicine.diagnostic_test ,business.industry ,Human heart ,Post injection ,Autonomic nervous system ,Norepinephrine ,Positron emission tomography ,medicine ,Catecholamine ,Radiology, Nuclear Medicine and imaging ,Nuclear medicine ,business ,Cardiac imaging ,medicine.drug - Abstract
Alterations of the cardiac autonomic nervous system play an important role in the pathway of many heart diseases. Nuclear imaging tools have been demonstrated to be useful for global and regional assessment of myocardial innervation. We used 11 C-meta-hydroxy-ephedrine ( 11 C-mHED), a catecholamine analogue, as a radiotracer usable with a PET/CT scanner to study the cardiac sympathetic system. After a fast and automatic synthesis of mHED and its labeling with 11 C, we acquired cardiac images by using a PET/ CT scanner. In this paper we present our preliminary results showing the radiotracer bio-distribution in humans 10 minutes post injection. The present study assesses the feasibility of PET/CT with the radiolabeled catecholamine analogue ( 11 C-mHED) in order to determine sympathetic innervation in the human heart. more...
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- 2014
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122. Basic Premises to Molecular Imaging and Radionuclide Therapy – Part 1
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F. Magrassi, Vincenzo Cuccurullo, Andrea Ciarmiello, Sean L. Kitson, and Luigi Mansi
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business.industry ,Radionuclide therapy ,Medicine ,Engineering ethics ,Molecular imaging ,Nuclear medicine ,business - Abstract
This manuscript is a complementary article to an accompanying paper, published in a forthcoming issue, which will give an overview on the central role of chelation in labelling radiocompounds; either for imaging and/or for radionuclide therapy. In order to facilitate a better understanding of the importance of Chelator-Based Imaging & Therapy, we will briefly discuss in this publication - which is partially intended as an introduction to the second paper - which contains the major basic principles of molecular imaging and radionuclide therapy. Although these issues are of interest in the general field of Nuclear Medicine; since the chelation process involves the labelling with radiometals; we aim to highlight examples of this category in this paper which concern this class of nuclides in this particular issue. more...
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- 2014
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123. Automated synthesis of [18F]fluorocholine using a modified GE TracerLab module
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Umberto Ficola, Sean L. Kitson, Luigi Mansi, Alessandra Sperandeo, Natale Quartuccio, and Angelina Cistaro
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business.industry ,Medicine ,business - Published
- 2014
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124. Role of PET and SPECT in the Study of Amyotrophic Lateral Sclerosis
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Vincenzo Cuccurullo, Natale Quartuccio, Angelina Cistaro, Maria Consuelo Valentini, Luigi Mansi, and Marco Pagani
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Pathology ,medicine.medical_specialty ,lcsh:Medicine ,Review Article ,General Biochemistry, Genetics and Molecular Biology ,Neuroimaging ,medicine ,Humans ,Amyotrophic lateral sclerosis ,Tomography, Emission-Computed, Single-Photon ,General Immunology and Microbiology ,medicine.diagnostic_test ,business.industry ,Amyotrophic Lateral Sclerosis ,lcsh:R ,Magnetic resonance imaging ,General Medicine ,Spinal cord ,medicine.disease ,Molecular Imaging ,3. Good health ,PET ,Glucose ,medicine.anatomical_structure ,Cerebral blood flow ,Positron emission tomography ,SPECT ,Cerebrovascular Circulation ,Positron-Emission Tomography ,Brainstem ,Primary motor cortex ,business - Abstract
Amyotrophic lateral sclerosis has been defined as a “heterogeneous group of neurodegenerative syndromes characterized by progressive muscle paralysis caused by the degeneration of motor neurons allocated in primary motor cortex, brainstem, and spinal cord.” A comprehensive diagnostic workup for ALS usually includes several electrodiagnostic, clinical laboratory and genetic tests. Neuroimaging exams, such as computed tomography, magnetic resonance imaging and spinal cord myelogram, may also be required. Nuclear medicine, with PET and SPECT, may also play a role in the evaluation of patients with ALS, and provide additional information to the clinicians. This paper aims to offer to the reader a comprehensive review of the different radiotracers for the assessment of the metabolism of glucose (FDG), the measurement of cerebral blood flow (CBF), or the evaluation of neurotransmitters, astrocytes, and microglia by means of newer and not yet clinically diffuse radiopharmaceuticals. more...
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- 2014
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125. Preface
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Luigi, Mansi and Sean L, Kitson
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Pharmacology ,Radiology, Nuclear Medicine and imaging - Published
- 2018
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126. Chun K. Kim and Katherine A. Zukotynski (editors): SPECT and SPECT/CT: a clinical guide
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Mariarosaria Manganelli and Luigi Mansi
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business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business ,Nuclear medicine - Published
- 2018
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127. Ely A. Wolin: Top 3 Differentials in Nuclear Medicine: A Case Review
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Luigi Mansi
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business.industry ,Medicine ,Library science ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business ,Case review - Published
- 2019
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128. Eleanor Mantel, Janet S. Reddin, Gang Cheng, Abass Alavi (Eds): Nuclear Medicine Technology. Review Questions for the Board Examinations, Fifth Edition. Springer International Publishing AG, 2018. ISBN 978-3-319-62499-0
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Luigi Mansi
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Publishing ,business.industry ,Library science ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Sociology ,business ,Technology review - Published
- 2019
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129. Abdelhamid H Elgazzar, Ismet Sarikaya (Eds): Nuclear Medicine Companion. A Case-Based Practical Reference for Daily Use
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Luigi Mansi
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medicine.medical_specialty ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,General Medicine ,business - Published
- 2019
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130. Clinical Nuclear Medicine in Pediatrics
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Luigi Mansi, Egesta Lopci, Vincenzo Cuccurullo, Arturo Chiti, Luigi Mansi, Egesta Lopci, Vincenzo Cuccurullo, and Arturo Chiti
- Subjects
- Infants, Radioisotope scanning, Children, Pediatric nuclear medicine, Nuclear medicine
- Abstract
This book provides a comprehensive state-of-the-art review of pediatric nuclear medicine, encompassing both diagnostic and therapeutic applications. Detailed attention is paid to the role of FDG PET-CT within oncology, but a variety of other long-established or less frequently used diagnostic procedures are also covered. Each indication is critically discussed from a clinical perspective, with analysis of benefits and limitations and comparison against the information yield of alternative techniques. The coverage of therapy based on radiopharmaceuticals includes the most relevant current strategies, including those utilizing radioiodine, MIBG, or radiolabelled peptides. In addition, issues concerning the radiation risk of nuclear medicine procedures in children are addressed. All chapters have been written by international experts and include the most up-to-date scientific and clinical information. more...
- Published
- 2016
131. PET-CT and PET-MRI in Neurology : SWOT Analysis Applied to Hybrid Imaging
- Author
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Andrea Ciarmiello, Luigi Mansi, Andrea Ciarmiello, and Luigi Mansi
- Subjects
- Tomography, Emission, Magnetic resonance imaging, Brain--Imaging
- Abstract
Using SWOT analysis, this book examines in detail the strengths and weaknesses of the hybrid modalities PET-CT and PET-MRI for imaging of the central nervous system, comparing their merits and evaluating their advantages over the stand-alone modalities. The aim is to employ a truly systematic approach in order to define the potential clinical benefit of these modalities and to identify shortcomings, opportunities, and threats. Clinical application of the modalities is explored in a range of conditions, including dementia and related disorders, movement disorders, psychiatric disorders, cerebrovascular disease, infection/inflammation, brain tumors, and pediatric neurologic disorders. In addition, the basics of hybrid imaging are addressed, covering physics, instrumentation, data analysis and quantitation, radiopharmaceuticals, and contrast media. PET-CT and PET-MRI in Neurology, written by experts from Europe and the United States, will be essential reading for imaging specialists and of value for neurologists, psychiatrists, neurosurgeons, and pediatricians. more...
- Published
- 2016
132. Molecular pathways and molecular imaging in breast cancer: An update
- Author
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Laura Evangelista, Anna Rita Cervino, Luigi Mansi, Marta Burei, Cervino, Ar, Burei, M, Mansi, Luigi, and Evangelista, L.
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,medicine.drug_class ,Apoptosis ,Breast Neoplasms ,Disease ,Breast cancer ,Internal medicine ,medicine ,Humans ,Neoplasm ,Radiology, Nuclear Medicine and imaging ,Radioactive Tracers ,medicine.diagnostic_test ,business.industry ,Cancer ,DNA ,medicine.disease ,Phenotype ,Molecular Imaging ,ErbB Receptors ,Positron emission tomography ,Estrogen ,Molecular Medicine ,Molecular imaging ,business - Abstract
Breast cancer is a heterogenic cancer being characterized by a variability of somatic mutations and in particular by different receptor expressions, such as estrogen, progesterone and human epidermal receptor. These phenotype characteristics play a crucial role in determining tumour response to various chemotherapies and other treatments and in the development of resistance to therapies. Positron emission tomography (PET) as a nuclear medicine technique, has recently demonstrated the advantages in determining the severity of disease and in evaluating the efficacy of treatments in a variety of neoplasm, including breast cancer. Because this procedure is able to pinpoint molecular activity within the body, it offers the potential to identify disease in its earliest stages as well as a patient's immediate response to therapeutic interventions in a non-invasive way. In this paper we performed an extended view about the correlation between molecular factors of breast cancer and PET tracers; in particular, we focalized our attention on their possible advantages in terms of 1) early detection of primary or recurrent cancer; 2) as a guide for target therapies and 3) for the evaluation of response to specific and now-available molecular treatments. more...
- Published
- 2013
- Full Text
- View/download PDF
133. Weighted registration of123I-FP-CIT SPECT images improves accuracy of binding potential estimates in pathologically low striatal uptake
- Author
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Giuliano Mariani, Giampiero Giovacchini, Martina Meniconi, Patrizia Lazzeri, Massimo Del Sette, Andrea Ciarmiello, Duccio Volterrani, Luigi Mansi, Claudio Guidotti, and Elena Carabelli
- Subjects
Reproducibility ,Correlation coefficient ,Physiology ,business.industry ,Clinical Biochemistry ,Binding potential ,Cell Biology ,computer.software_genre ,Imaging phantom ,Correlation ,Text mining ,Voxel ,Spect imaging ,Medicine ,Nuclear medicine ,business ,computer - Abstract
To test whether the use of a striatum weighted image may improve registration accuracy and diagnostic outcome in patients with parkinsonian syndromes (PS), weighted images were generated by increasing signal intensity of striatal voxels and used as intermediate dataset for co-registering the brain image onto template. Experimental validation was performed using an anthropomorphic striatal phantom. 123I-FP-CIT SPECT binding ratios were manually determined in 67 PS subjects and compared to those obtained using unsupervised standard (UWR) and weighted registered (WR) approach. Normalized cost function was used to evaluate the accuracy of phantom and subjects registered images to the template. Reproducibility between unsupervised and manual ratios was assessed by using intra-class correlation coefficient (ICC) and Bland and Altman analysis. Correlation coefficient was used to assess the dependence of semi-quantitative ratios on clinical findings. Weighted method improves accuracy of brain registration onto template as determined by cost function in phantom (0.86 ± 0.06 vs. 0.98 ± 0.02; Student's t-test, P = 0.04) and in subject scans (0.69 ± 0.06 vs. 0.53 ± 0.06; Student's t-test, P more...
- Published
- 2013
- Full Text
- View/download PDF
134. Bone Metastases Radiopharmaceuticals: An Overview
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Oscar Tamburrini, Vincenzo Cuccurullo, Antonio Rotondo, Giuseppe Lucio Cascini, Luigi Mansi, Cuccurullo, Vincenzo, Cascini, Gl, Tamburrini, O, Rotondo, Antonio, and Mansi, Luigi
- Subjects
Fluorine Radioisotopes ,medicine.medical_specialty ,Diagnostic methods ,Bone Neoplasms ,Scintigraphy ,Malignancy ,Choline ,Imaging modalities ,Iodine Radioisotopes ,Fluorodeoxyglucose F18 ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Tomography, Emission-Computed, Single-Photon ,Pharmacology ,Diphosphonates ,medicine.diagnostic_test ,business.industry ,Technetium ,medicine.disease ,Combined approach ,Dihydroxyphenylalanine ,3-Iodobenzylguanidine ,Radioimmunodetection ,Positron emission tomography ,Positron-Emission Tomography ,Sodium Fluoride ,Radiology ,Radiopharmaceuticals ,Somatostatin ,business ,Nuclear medicine ,Thymidine - Abstract
The skeleton is one of the preferential sites for metastases of solid tumors, and metastatic disease is the most common malignancy of the bone. Diagnosis and evaluation of skeletal metastases require more frequently a combined approach of different diagnostic methods. Between the currently available imaging modalities, a major role is devoted to two radionuclide functional techniques namely scintigraphy and positron emission tomography (PET) imaging. Both these techniques require the use of different radiopharmaceuticals. The aim of this paper is to review the most important radiocompounds that can be successfully used to detect and/or characterize bone metastases. more...
- Published
- 2013
- Full Text
- View/download PDF
135. Neurological applications for myocardial MIBG scintigraphy
- Author
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Lucio Giuseppe Cascini, Vincenzo Cuccurullo, Antonio Restuccia, Oscar Tamburrini, Antonio Rotondo, and Luigi Mansi
- Subjects
medicine.medical_specialty ,Pathology ,Sympathetic Nervous System ,Disease ,3-Iodobenzylguanidine ,Scintigraphy ,Sensitivity and Specificity ,Internal medicine ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Cardiac imaging ,Denervation ,medicine.diagnostic_test ,business.industry ,Parkinsonism ,Myocardial Perfusion Imaging ,Heart ,Parkinson Disease ,General Medicine ,medicine.disease ,Pathophysiology ,Cardiology ,Biomarker (medicine) ,business - Abstract
Signs or symptoms of impaired autonomic regulation of circulation are typically present in patients affected by Parkinson's disease (PD), in agreement with the cardiac sympathetic denervation discovered by Goldstein more than 15 yrs. ago. In particular, the majority of PD patients have a diffuse left ventricular myocardial sympathetic denervation, being a normal neurological condition present only in a small number of affected subjects. Actually MIBG cardiac imaging is a universally accepted method to estimate cardiac sympathetic innervations. This review covers the role of MIBG cardiac imaging in PD as well as in other parkinsonisms, focusing the attention on technical problems and pathophysiological premises for cardiac denervation. In particular new emerging data support the role of MIBG as biomarker of PD, also before motor symptoms became clinically evident. Therefore the timing of cardiac noradrenergic denervation in PD is a key issue and we want to update the analysis of autonomic cardiovascular abnormalities studied with MIBG in PD and related disorders. more...
- Published
- 2013
- Full Text
- View/download PDF
136. The delicate balance between present and future
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Luigi Mansi, Leonardo Pace, and Marco Spadafora
- Subjects
medicine.medical_specialty ,Evidence-Based Medicine ,Lung Neoplasms ,SPN ,PET/CT ,business.industry ,MEDLINE ,Reproducibility of Results ,Solitary Pulmonary Nodule ,General Medicine ,Evidence-based medicine ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Balance (accounting) ,030228 respiratory system ,Positron Emission Tomography Computed Tomography ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Whole Body Imaging ,business - Published
- 2016
137. Molecular Imaging of Huntington's Disease
- Author
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Andrea, Ciarmiello, Giampiero, Giovacchini, Elisabetta, Giovannini, Patrizia, Lazzeri, Elisa, Borsò, Antonio, Mannironi, and Luigi, Mansi
- Subjects
Genetic Markers ,Huntingtin Protein ,Brain ,Prognosis ,Magnetic Resonance Imaging ,Molecular Imaging ,Huntington Disease ,Phenotype ,Predictive Value of Tests ,Positron-Emission Tomography ,Mutation ,Animals ,Humans ,Genetic Predisposition to Disease - Abstract
The onset and the clinical progression of Huntington Disease (HD) is influenced by several events prompted by a genetic mutation that affects several organs tissues including different regions of the brain. In the last decades years, Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) helped to deepen the knowledge of neurodegenerative mechanisms that guide to clinical symptoms. Brain imaging with PET represents a tool to investigate the physiopathology occurring in the brain and it has been used to predict the age of onset of the disease and to evaluate the therapeutic efficacy of new drugs. This article reviews the contribution of PET and MRI in the research field on Huntington's disease, focusing in particular on some most relevant achievements that have helped recognize the molecular changes, the clinical symptoms and evolution of the disease. J. Cell. Physiol. 232: 1988-1993, 2017. © 2016 Wiley Periodicals, Inc. more...
- Published
- 2016
138. Segmental
- Author
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Marco, Spadafora, Leonardo, Pace, and Luigi, Mansi
- Subjects
Europe ,Lung Neoplasms ,Fluorodeoxyglucose F18 ,Cost-Benefit Analysis ,Positron Emission Tomography Computed Tomography ,Practice Guidelines as Topic ,Reproducibility of Results ,Solitary Pulmonary Nodule ,Nuclear Medicine ,Radiopharmaceuticals ,Medical Oncology ,Sensitivity and Specificity - Published
- 2016
139. Radioguided surgery with radiolabeled somatostatin analogs: not only in GEP-NETs
- Author
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Vincenzo Cuccurullo, Giuseppe Danilo Di Stasio, Luigi Mansi, Cuccurullo, Vincenzo, Di Stasio, Giuseppe Danilo, and Mansi, Luigi
- Subjects
Male ,Pathology ,Radiology, Nuclear Medicine and Imaging ,Intraoperative probe ,Lung Neoplasms ,medicine.medical_treatment ,Neuroendocrine tumors ,Scintigraphy ,Brain cancer ,030218 nuclear medicine & medical imaging ,Somatostatin analog ,0302 clinical medicine ,Breast cancer ,Medicine ,Receptors, Somatostatin ,medicine.diagnostic_test ,Somatostatin receptor ,Brain Neoplasms ,Pancreatic Neoplasm ,General Medicine ,Radioguided surgery ,Molecular Imaging ,111In-pentetreotide ,Neuroendocrine Tumors ,Somatostatin ,030220 oncology & carcinogenesis ,Radiopharmaceutical ,Female ,Lung cancer ,Epithelioid cell ,Breast Neoplasm ,Human ,medicine.medical_specialty ,Intestinal Neoplasm ,Breast Neoplasms ,Brain Neoplasm ,03 medical and health sciences ,Immune system ,Neuroendocrine tumor ,Stomach Neoplasm ,Stomach Neoplasms ,Intestinal Neoplasms ,Humans ,Radionuclide Imaging ,business.industry ,medicine.disease ,Radiation therapy ,Lung Neoplasm ,Pancreatic Neoplasms ,Radiopharmaceuticals ,business - Abstract
Radioguided surgery (RGS) is a surgical technique that, using intra-operative probes, enables the surgeon to identify tissues preoperatively "marked" by a radiopharmaceutical. Somatostatin receptors (SSTRs) are present in the majority of neuroendocrine cells and may be over-expressed not only by tumor cells, but also by endothelial cells of peritumoral vessels, inflammatory cells and cells of the immune system, such as activated lymphocytes, monocytes and epithelioid cells. This extra neoplastic uptake is the rationale for the use of radiolabeled somatostatin analogs (SSAs) either in some tumors not expressing SSTRs or in various non-oncological diseases. The crucial point of RGS technique lays in the establishment of a favorable tumor-to-background ratio (TBR). A wide range of probe systems are available with different detectors and many radiopharmaceuticals have been experimented and utilized, mainly using g-detection probes; in order to widen RGS application field, newer approaches with b- or b+ emitting radioisotopes have also been proposed. Together with the consolidated clinical use, a promising and effective employment of RGS may be found in neuroendocrine tumors (NETs) using 111In-pentetreotide (OCT). RGS with OCT has been demonstrated useful in the management of patients with gastroenteropancreatic (GEP) tumors, lung, brain and breast cancer. Preoperative scintigraphy or PET with DOTA-peptides combined with RGS increases the rate of successful surgery. Preliminary studies with b- probes using 90Y-SSA suggest the possible interest of this approach in patients undergoing peptide receptor radiotherapy. more...
- Published
- 2016
140. Contrast-Enhanced Ultrasound in the Assessment of Patients with Indeterminate Abdominal Findings at Positron Emission Tomography Imaging
- Author
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Orlando Catalano, Luigi Mansi, Vincenza Granata, Secondo Lastoria, Roberta Fusco, Paolo Vallone, Fabio Sandomenico, Antonella Petrillo, and Sergio Venanzio Setola
- Subjects
Adult ,Male ,medicine.medical_specialty ,Acoustics and Ultrasonics ,Adolescent ,Biophysics ,Contrast Media ,Standardized uptake value ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Biopsy ,Abdomen ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Ultrasonography ,Fluorodeoxyglucose ,Aged, 80 and over ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Gallbladder ,Ultrasound ,Reproducibility of Results ,Middle Aged ,Image Enhancement ,medicine.anatomical_structure ,Liver ,Positron emission tomography ,030220 oncology & carcinogenesis ,Abdominal Neoplasms ,Positron-Emission Tomography ,Female ,Radiology ,Tomography ,business ,Spleen ,medicine.drug ,Contrast-enhanced ultrasound - Abstract
Widespread use of fluorodeoxyglucose-positron emission tomography (PET) in cancer imaging may result in a number of indeterminate and false-positive findings. We investigated the role of contrast-enhanced ultrasound (CEUS) as a second-level option after inconclusive PET. We reviewed CEUS images acquired over 4 y, selecting the examinations performed specifically to better assess an unclear PET image. Final diagnosis was confirmed by biopsy, surgery, further imaging or follow-up. Seventy CEUS examinations were performed after a PET scan (44 PET examinations, 19 PET-computer tomography [CT] examinations and 7 PET-CECT examinations). The target organ was the liver in 54 cases, spleen in 12, gallbladder in 2 and pancreas and kidney in one each. In 6 of 70 cases, CEUS was performed because of a negative PET (no uptake) despite an abnormal finding on the CT images of the PET-CT study; CEUS allowed a correct diagnosis in all of these. In 20 of 70 cases, the PET findings were categorized as indeterminate and non-specific (non-specific fluorodeoxyglucose uptake in PET report with no standardized uptake value given); CEUS reached a correct diagnosis in 19 of the 20 cases with one false negative. In 34 of 70 cases, PET was indeterminate, but specific (fluorodeoxyglucose uptake with a standardized uptake value provided); CEUS reached a correct diagnosis in 30 of these 34 cases. In 10 of 70 cases, PET was categorized as determinate but to be investigated because of discrepancy with clinical or imaging findings; CEUS a definitive diagnosis in 9 of 10 cases. CEUS proved to be effective option in the assessment of cancer patients with indeterminate PET findings. more...
- Published
- 2016
141. Clinical Imaging Experimental Example in Pathology
- Author
-
Maria Paola Belfiore, Roberto Grassi, Graziella Di Grezia, and Luigi Mansi
- Subjects
medicine.medical_specialty ,business.industry ,Medical imaging ,Medicine ,Clinical imaging ,Radiology ,business - Abstract
Diagnostic imaging may significantly and interactively help pathologists in a number of ways with its ability to detect and characterize human diseases ante- and postmortem using noninvasive or minimally invasive approaches. more...
- Published
- 2016
- Full Text
- View/download PDF
142. Diagnostic Imaging and Pathology
- Author
-
Luigi Mansi, Roberto Grassi, and Vincenzo Cuccurullo
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Cancer ,Disease ,medicine.disease ,Living body ,030218 nuclear medicine & medical imaging ,Functional imaging ,03 medical and health sciences ,0302 clinical medicine ,Molecular level ,Medical imaging ,Medicine ,Molecular imaging ,business ,030217 neurology & neurosurgery - Abstract
Molecular imaging is rapidly gaining importance in biomedical research and clinical diagnostics. In cancer patients, biochemical changes in cell metabolism occur before a tumor mass forms. It is now possible to study molecular kinetics with molecular tracers, that is, using “tracing” molecules that follow the same path as do the native molecules but to which a label detectable from outside the body has been added. This enables physicians to peer into the living body to identify disease, monitor progression, or treat medical conditions at a molecular level. Here, we learn how the term “molecular imaging” may optimize a new paradigm of tailored medicine, in which the individual patient, rather than the disease, is the focus. more...
- Published
- 2016
- Full Text
- View/download PDF
143. Diagnostic Imaging Techniques: Lessons Learned
- Author
-
Luigi Mansi, Roberto Grassi, Antonio Rotondo, and Vincenzo Cuccurullo
- Subjects
Modern medicine ,medicine.medical_specialty ,Animal imaging ,business.industry ,Medical imaging ,Medicine ,Medical physics ,Disease ,Clinical imaging ,business - Abstract
The identity of modern medicine has changed and become “tailored medicine” that focuses more on the individual patient and less on the disease. Although the most recent pathological procedures have certainly increased our ability to obtain more information that also includes prognostic content, pathology alone cannot answer all the questions clinicians and surgeons have in this new scenario. In this sense, information that also includes pathophysiological issues may significantly improve our knowledge of the patient. A fundamental move towards tailored medicine may be obtained through an ever-closer connection between pathology and diagnostic imaging. Diagnostic imaging may play a primary role in improving the effectiveness of pathology in an interactive and co-operative scenario in which the final goal is improvement of the information acquired, better defining each individual patient. more...
- Published
- 2016
- Full Text
- View/download PDF
144. PET-CT and PET-MRI in Neurology
- Author
-
Luigi Mansi and Andrea Ciarmiello
- Subjects
PET-CT ,medicine.medical_specialty ,Neurology ,business.industry ,Behavioral neurology ,Medicine ,business ,Nuclear medicine - Published
- 2016
- Full Text
- View/download PDF
145. Preclinical Imaging: Experimental Example
- Author
-
Claudia Rossi, Roberto Grassi, Francesca Iacobellis, Daniela Berritto, and Luigi Mansi
- Subjects
medicine.medical_specialty ,Preclinical research ,Bowel ischemia ,Computer science ,Small animal ,medicine ,Medical physics ,Preclinical imaging - Abstract
Dedicated small animal imaging represents an innovative and fast-growing tool that has demonstrated promising results in the field of preclinical research. New technologies constitute a key factor in the success and timelines of research because of the possibility of conducting longitudinal studies on the same animal. In this chapter, we report an example from our experience with the analysis of bowel ischemia via micro–magnetic resonance imaging to highlight the use of preclinical imaging as a helpful support to the pathophysiological comprehension of diseases. more...
- Published
- 2016
- Full Text
- View/download PDF
146. Clinical Nuclear Medicine in Pediatrics
- Author
-
Luigi Mansi, Egesta Lopci, Arturo Chiti, Vincenzo Cuccurullo, Mansi, Luigi, Lopci, Egesta, Cuccurullo, Vincenzo, and Chiti, Arturo
- Subjects
medicine.medical_specialty ,business.industry ,Medicine (all) ,Family medicine ,Medicine ,business - Abstract
This book provides a comprehensive state-of-the-art review of pediatric nuclear medicine, encompassing both diagnostic and therapeutic applications. Detailed attention is paid to the role of FDG PET-CT within oncology, but a variety of other long-established or less frequently used diagnostic procedures are also covered. Each indication is critically discussed from a clinical perspective, with analysis of benefits and limitations and comparison against the information yield of alternative techniques. The coverage of therapy based on radiopharmaceuticals includes the most relevant current strategies, including those utilizing radioiodine, MIBG, or radiolabelled peptides. In addition, issues concerning the radiation risk of nuclear medicine procedures in children are addressed. All chapters have been written by international experts and include the most up-to-date scientific and clinical information. more...
- Published
- 2016
- Full Text
- View/download PDF
147. Clinical Techniques in Humans
- Author
-
Luigi Mansi, Roberto Grassi, and Vincenzo Cuccurullo
- Subjects
medicine.diagnostic_test ,business.industry ,Computer science ,Normal tissue ,Magnetic resonance imaging ,Context (language use) ,Gold standard (test) ,T2 relaxation ,medicine ,Medical imaging ,Ultrasonography ,Spin density ,business ,Biomedical engineering - Abstract
Traditional radiology is based on differences in density of lesions compared with the surrounding normal tissue. These techniques are fast, cheap, easily performed, and available everywhere, even at the bedside. Ultrasonography has strong diagnostic accuracy when evaluating both superficial and deep structures, discriminating between solid and liquid components. Computed tomography is the current major radiological technique, with X-rays allowing three-dimensional spatial and structural analysis. Magnetic resonance imaging can produce multi-parametric images depending on the molecular context. Different tissue variables, including spin density, T1 and T2 relaxation times, flow, and spectral shifts, can be used to construct images. Nuclear medicine is a medical specialty that uses radionuclides for diagnostic and therapeutic purposes. In contrast to morphostructural techniques, where pathology is the gold standard, nuclear medicine is based on pathophysiological premises. more...
- Published
- 2016
- Full Text
- View/download PDF
148. PET/CT Versus PET/MRI
- Author
-
Ignasi Carrió, Luigi Mansi, and Andrea Ciarmiello
- Subjects
PET-CT ,Hybrid machine ,medicine.diagnostic_test ,business.industry ,Positron emission tomography ,Medicine ,Computed tomography ,Magnetic resonance imaging ,Tomography ,business ,Nuclear medicine ,Correction for attenuation ,Imaging modalities - Abstract
This chapter summarizes the findings of a global survey aimed at assessing the strengths, weaknesses, opportunities, and threats (so-called SWOT analysis) of hybrid imaging (HI). Hybrid imaging comprises three imaging modalities: single-photon emission tomography (SPET)/computed tomography (CT), positron emission tomography (PET)/CT, and PET/magnetic resonance imaging (MRI). The potential benefit of these modalities has been evaluated with SWOT approach in neurology as well as in whole-body application, centering the analysis mainly on the comparison between PET/CT and PET/MRI to better understand possible spaces of application and future diffusion of the latter. more...
- Published
- 2016
- Full Text
- View/download PDF
149. Peculiar Aspects and Problems of Diagnostic Nuclear Medicine in Paediatrics
- Author
-
Maria Rosaria Prisco, Vincenzo Cuccurullo, and Luigi Mansi
- Subjects
Pediatrics ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Positron emission tomography ,First line ,Medicine ,Nuclear medicine ,business ,Complement (complexity) - Abstract
Diagnostic Nuclear Medicine in Paediatrics presents peculiar aspects and problems respect to its utilization in adults. In particular, because of the presence of ionizing radiations, its clinical use has to be justified on the basis of a favourable cost/effectiveness analysis. Technical problems may be found in all the steps of the examination, because they can be associated with many phases of the study as patient’s preparation, positioning, restraining, injection. The communication with the infant and her/his caregivers is very important to avoid narcosis and sedation and to optimize the diagnostic procedure. Nevertheless, because of its capability to give functional information, nuclear medicine procedures may find an important role in the diagnostic scenario either as first line techniques and/or to complement diagnosis with a further contribution more related to prognosis and therapy. more...
- Published
- 2016
- Full Text
- View/download PDF
150. Ultrasound in the Evaluation of Cutaneous Diseases
- Author
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Roberto Grassi, Claudia Rossi, Graziella Di Grezia, Maria Paola Belfiore, Vincenzo Cuccurullo, and Luigi Mansi
- Subjects
medicine.medical_specialty ,integumentary system ,medicine.diagnostic_test ,business.industry ,Merkel cell carcinoma ,Ultrasound ,Epidermoid cyst ,medicine.disease ,Optical coherence tomography ,Dermoid cyst ,Medical imaging ,Medicine ,Radiology ,Skin melanoma ,business - Abstract
This chapter focuses on high-frequency ultrasound (HFUS) as a technique for studying the skin. Evolving technology used in animal research has led to the implementation of new technology in diagnostic imaging in humans. In this chapter, devoted to the diagnosis of skin diseases, we focus our analysis on information obtained from HFUS (20–100 MHz), which provides better resolution and therefore may be proposed for evaluation of the skin. more...
- Published
- 2016
- Full Text
- View/download PDF
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