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Crops that provide ecosystem services (ESs) beyond crop production are gaining interest from farmers, policymakers, and society at large. Cover crops (CCs), grown either as the sole crop or mixture, provide multiple ESs that contribute to achieving the sustainable development goals (SDGs) of the United Nations. Little is known to date as to whether and to what extent ESs provided by CCs are affected by genotype × environment × management (G×E×M) interactions. Understanding these interactions could help to maximize the ESs of CCs while minimizing their ecosystem disservices. To this end, we highlight existing research gaps in CC research and then propose key research strategies, including the need for a paradigm shift in defining, managing, and utilizing CCs. Cover crops (CCs) provide multiple ecosystem services (ESs) that contribute to achieving the United Nations Sustainable Development Goals. Current knowledge gaps in CC research and management impede maximizing the ES potential of CCs. Six research priorities and a paradigm shift are proposed to bridge the current knowledge gaps in defining, managing, and utilizing CCs. A better understanding of genotype × environment × management interactions of CCs is important in minimizing their ecosystem disservices. [ABSTRACT FROM AUTHOR]

Abstract Human–wildlife conflicts have intensified by many folds and at different levels in recent years. The same is true in the case of the Hindu Kush Himalaya (HKH), the roof of the world, and a region known for its wealth in biodiversity. We present a systematic literature review (SLR) using the search, appraisal, synthesis, and analysis (SALSA) framework; and for spatial and network analysis, we employed the VOSviewer software. The review—covering 240 peer—articles within a span of 27 years (from 1982 to 2019)—revealed that in the last decade, there was a 57% increase in publications but with a disproportionate geographical and thematic focus. About 82% of the research concentrated on protected areas and large carnivores and mega herbivores played a big role in such conflicts. About 53% of the studies were based on questionnaires, and the main driver reported was habitat disturbance of animals due to land‐cover change, urbanization, and increase in human population. On the management front, the studies reported the use of traditional protection techniques like guarding and fencing. Our analysis of 681 keywords revealed a prominent focus on ‘human‐wildlife conflict,’ ‘Nepal,’ ‘Bhutan,’ ‘Snow Leopard,’ and ‘Leopard’ indicating the issue linked with these species and countries. The involvement of 640 authors from 36 countries indicates increasing interest, and Nepal and India are playing key roles in the region. As for the spatial analysis that was conducted, while it showed regional variations, there were conspicuous limitations in terms of having a transboundary focus. Thus, particular attention ought to be paid to building transboundary partnerships and improving management interventions; there is also a pressing need to understand the patterns of human–wildlife convergence, especially involving meso‐mammals.

Abstract Objective This study aimed to explore current attitudes towards sun protection, and sun-seeking behaviour among young Australian adolescents. It was done as part of a larger project aiming to develop a digital resource to support young people in making informed sun-health decisions. Results Ten (4 male, 6 female) adolescents (12–13 years of age) living in Perth (Western Australia) were recruited through a social media-based strategy. Each participant engaged in a semi-structured telephone interview which explored their sun-health decision-making, with interview transcripts assessed qualitatively using NVivo. Three major themes (and eight sub-themes) were identified: (1) ‘personal sun health considerations’; (2) ‘attitudes towards sun protection’; and (3) ‘recommendations’. The importance of sun protection was appreciated by participants. However, females were more diligent in the use of sun protection while males were indifferent. Behaviours were influenced by parental input, the school environment and engagement in sport. Adolescents had limited knowledge of the UV Index and its implications for sun protection, and the health importance of sun-derived vitamin D. Overall, the importance of sun protection was acknowledged but did not consistently translate into sun protective behaviours.

The International Society of Nephrology has adopted a proactive approach to defining the current state of kidney care and unmet needs through a multifaceted Closing the Gaps initiative. As part of this initiative, the International Society of Nephrology convened a meeting of experts to develop an approach to tackle acute kidney injury and chronic kidney disease (CKD). This manuscript expands on the recently published International Society of Nephrology CKD Roadmap and reports on the discussions of the working group assigned to the task of reviewing the global impact of complication of CKD. The working group defined the following goals: Goal 1: Optimize the management of anemia and endocrine and metabolic abnormalities associated with CKD. The impact of these conditions at a global level is not well understood, particularly in regions where renal replacement therapy is not readily available. Some treatment regimens may be affordable in low- and middle-income countries and if implemented, could have an impact on the burden of suffering associated with CKD. Goal 2: Improve the prevention and management of cardiovascular complications linked to CKD. Most research on cardiovascular complications of CKD has focused on atherosclerotic diseases (myocardial infarction, ischemic stroke, and peripheral gangrene). There has been growing recognition that other forms of cardiovascular diseases, such as heart failure, valvular disease and arrhythmias, have a major impact on patient outcomes. Much less is known about the mechanisms and treatment of these non-atherosclerotic complications. Goal 3: Improve the diagnosis and management of symptoms associated with CKD. Symptom management is one of the greatest challenges in the management of CKD, with limited knowledge about the mechanisms associated with the development of these common problems and how best to characterize them into usable clinical phenotypes. Improved understanding of the complications of CKD may alleviate suffering and prolong life among millions of people worldwide both in developed countries and in regions where renal replacement therapy is not widely available.

Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are on a spectrum of cutaneous drug reactions characterized by pan-epidermal necrosis with SJS affecting < 10% of body surface area (BSA), TEN > 30%, and SJS/TEN overlap between 10 and 30%. Severity-of-illness score for toxic epidermal necrolysis (SCORTEN) is a validated tool to predict mortality rates based on age, heart rate, BSA, malignancy and serum urea, bicarbonate, and glucose. Despite improved understanding, SJS/TEN mortality remains constant and therapeutic interventions are not universally accepted for a number of reasons, including rarity of SJS/TEN; inconsistent definition of cases, disease severity, and endpoints in studies; low efficacy of interventions; and variations in treatment protocols. Apart from mortality, none of the other endpoints used to evaluate interventions, including duration of hospitalization, is sufficiently standardized to be reproducible across cases and treatment centers. Some of the gaps in SJS/TEN research can be narrowed through international collaboration to harmonize research endpoints. A case is made for an urgent international collaborative effort to develop consensus on definitions of endpoints such as disease status, progression, cessation, and complete re-epithelialization in interventional studies. The deficiencies of using BSA as the sole determinant of SJS/TEN severity, excluding internal organ involvement and extension of skin necrosis beyond the epidermis, are discussed and the role these factors play on time to healing and mortality beyond the acute stage is highlighted. The potential role of artificial intelligence, biomarkers, and PET/CT scan with radiolabeled glucose as markers of disease status, activity, and therapeutic response is also discussed.

Loss of natural habitat through land‐use change threatens bees. Urbanisation is a major, increasing form, of habitat loss, and a novel, pervasive form of disturbance known to impact bee diversity and abundance in a variety of often inconsistent ways.We conducted a comprehensive, semi‐quantitative review, involving 215 studies, on responses of bees to urban landscapes, and local and landscape variables proposed to influence bee abundance and diversity.Urban areas tend to be favourable habitat for bees compared with agricultural ones, but compared with natural areas, urban areas often host more abundant populations yet fewer species.Factors associated with urban landscapes, including changes in foraging resources and nesting substrate types and availability, contribute to changes in abundance, species richness, and composition of native bee assemblages. However, the conclusions of studies vary greatly because of the difference in the ecological traits of bees, habitats surveyed, and geographic region, as well as noise in the data resulting from inconsistencies in sampling methodology, and definitions of 'urban' and 'natural'.Identifying what biotic and abiotic features of cityscapes promote or threaten the persistence of urban bee diversity is critical. We provide a comprehensive evaluation of how bees (both in aggregate and according to their ecological guild) have responded to the urban environment, identify gaps in knowledge in urban bee ecology, and make recommendations to advance our understanding of bees in urban environments to promote conservation of diverse bee communities. [ABSTRACT FROM AUTHOR]

As the interest in new, natural, sustainable products arises in many fields, wild plants are reconsidered as providers of traditional or innovative applications. The notion of ecosystem services (ES) provides a frame to evaluate their benefits, but is still scarcely applied to endemic floras. The present study reviews the available literature on the ES provided by the 494 taxa endemic to Greece that are present in Peloponnese. Six main categories are isolated: medical, aromatic, folk medicine, antimicrobial, environmental and craftsmanship interests. The literature documents such ES for 24.7% of the endemic taxa, with Lamiaceae, Asteraceae and Boraginaceae as the families with the highest numbers of documented taxa. Spatial hotspots with a high density in taxa providing ES are mapped, while gaps of knowledge on the ES of endemic taxa are highlighted. For the first time, to our knowledge, taxonomic and phylogenetic bounds between taxa are exploited as a base to explore potential properties for endemic taxa. The basis for the development of predictive tools utilizing literature review datasets is set. Final outcomes also provide robust scientific evidence to support decision and policy making for the sustainable use and management of rural areas. The development of cultivation areas for threatened taxa of interest is suggested as a potent conservation measure, by selecting fields according to habitat suitability models. [ABSTRACT FROM AUTHOR]

Objective: The European Reference Network on Rare Endocrine Conditions (Endo-ERN), operational since 2017, consists of 71 health care providers (HCPs) in 19 EU member states. Our objective was to assess education and knowledge on rare endocrine conditions. Design and methods: A survey was developed and sent through the DIGIT-EUROSURVEY system to all Endo-ERN HCPs. Results: Response rate was 55% (n = 146), 95% physicians, 58% >20 years of experience, 96% academics. Largest knowledge gaps were reported for the transition and neonatal ages, and for the GPs. Less than 50% of HCPs had structured educational rare diseases (RD) plans, while 86% used RD specific guidelines. HCPs would sh are educational materials within Endo-ERN (74%), and participate in an accreditation model (85%). E-learning portals of the endocrine scientific societies used 58 % (ESPE) and 64% (ESE). Most participants (90%) regarded Endo-ERN coordinated educational activities (annual meetings slots, webinars, etc.) as highly important and supported a common educational platform. Social media was perceived as important for educating patients (86%) but not for physicians (36%). Seventy-five % had developed patient e ducation materials; only 31% had specific children’s materials, and by-country avail ability varied from 0 to 100%. Respondents provided newly diagnosed patients with their own material in the national language (81%); referred to advocacy groups (68%), and relevant online sources (50%). Respondents believed the European Commission should fund education through Endo-ERN. Conclusion: Identified knowledge gaps in rare endocrine disorders set the b asis for fast catch-up through collaboration, alignment with patients’ needs, and further development of existing and newly developed educational resources.

The effects of climate change (CC) on contaminants and their potential consequences to marine ecosystem services and human wellbeing are of paramount importance, as they pose overlapping risks. Here, we discuss how the interaction between CC and contaminants leads to poorly constrained impacts that affects the sensitivity of organisms to contamination leading to impaired ecosystem function, services and risk assessment evaluations. Climate drivers, such as ocean warming, ocean deoxygenation, changes in circulation, ocean acidification, and extreme events interact with trace metals, organic pollutants, excess nutrients, and radionuclides in a complex manner. Overall, the holistic consideration of the pollutants-climate change nexus has significant knowledge gaps, but will be important in understanding the fate, transport, speciation, bioavailability, toxicity, and inventories of contaminants. Greater focus on these uncertainties would facilitate improved predictions of future changes in the global biogeochemical cycling of contaminants and both human health and marine ecosystems.

Around the globe, human behavior and ecosystem health have been extensively and sometimes severely affected by the unprecedented COVID-19 pandemic. Most efforts to study these complex and heterogenous effects to date have focused on public health and economics. Some studies have evaluated the pandemic's influences on the environment, but often on a single aspect such as air or water pollution. The related research opportunities are relatively rare, and the approaches are unique in multiple aspects and mostly retrospective. Here, we focus on the diverse research opportunities in disease ecology and ecosystem sustainability related to the (intermittent) lockdowns that drastically reduced human activities. We discuss several key knowledge gaps and questions to address amid the ongoing pandemic. In principle, the common knowledge accumulated from invasion biology could also be effectively applied to COVID-19, and the findings could offer much-needed information for future pandemic prevention and management. [ABSTRACT FROM AUTHOR]

There is an absence of common sexual health education curricula in Canada, and learning experiences differ for youth across the country. Without a national standardized system to monitor the sexual health education delivery, research is needed to better understand these diverse learning experiences. Gender and sexually diverse youth in Canada may be overlooked and subjected to information that is exclusively focused on cisgender, heterosexual people, and experiences. Our study explored sexual health education learning experiences for youth in Canada and examined group differences based on self-reported gender and sexual identities. Participants (N = 1507) completed an online survey with demographic questions and questions about experiences with sexual health education. Participants were 16–25 years old (M = 18.06) and our sample was comprised of many sexually diverse participants (n = 857). Most youth in our study received sexual health education (94%), although many received only a few (1-3) lessons or workshops (41%). Most participants received education in a school (95%) and from a teacher (87%). Differences in education context and educator type between gender and sexually diverse youth were not significant. The most commonly reported topics youth were exposed to were sexually transmitted infections (92%), physical anatomy and/or puberty (89%), and pregnancy and birth control (79%). Gender and sexually diverse youth reported lower percentages of topics learned for nearly all sexual topics listed in our study. Study findings are discussed by examining both strengths and areas for improvement for supporting youth learning through sexual health education in Canada. [ABSTRACT FROM AUTHOR]

The family Mephitidae is almost exclusively restricted to the Americas, 9 of 11 species belonging to 3 genera are distributed from southern Canada to Chile. Despite the high diversity and continental distribution of this taxon, there is no quantitative review that evaluates the state of research to determine current advances and knowledge gaps, as well as the research efforts necessary to develop effective conservation programs and reduce potential threats to species. Our goal was to analyze the scientific literature on the family Mephitidae in the Americas published from 1900 to 2021 to identify the patterns and potential causes of bias based on species, research topics, in addition to regions and countries, and to define research priorities to guide future efforts. We recorded a total of 926 studies related to the American mephitids. The number of publications by species, research topic, and the geographic area was distributed heterogeneously, but we observed significantly marked biases. The most studied species was Mephitis mephitis, most of the studies focused on diseases and pathologies, and most of the research was conducted in North America, mainly in the United States. Overall, there was an accumulated and gradual increase in the number of publications over time, with greater scientific production between 2010 and 2021. Our review shows that the research allocation to mephitids, except for Spilogale putorius, is driven by economic or human interest rather than conservation reasons. We prioritize future research towards mephitid species, research topics, and geographic areas in the Americas that need it the most to reduce the scientific gap and to increase the availability of relevant information. [ABSTRACT FROM AUTHOR]

River systems originating from the Upper Indus Basin (UIB) are dominated by runoff from snow and glacier melt and summer monsoonal rainfall. These water resources are highly stressed as huge populations of people living in this region depend on them, including for agriculture, domestic use, and energy production. Projections suggest that the UIB region will be affected by considerable (yet poorly quantified) changes to the seasonality and composition of runoff in the future, which are likely to have considerable impacts on these supplies. Given how directly and indirectly communities and ecosystems are dependent on these resources and the growing pressure on them due to ever‐increasing demands, the impacts of climate change pose considerable adaptation challenges. The strong linkages between hydroclimate, cryosphere, water resources, and human activities within the UIB suggest that a multi‐ and inter‐disciplinary research approach integrating the social and natural/environmental sciences is critical for successful adaptation to ongoing and future hydrological and climate change. Here we use a horizon scanning technique to identify the Top 100 questions related to the most pressing knowledge gaps and research priorities in social and natural sciences on climate change and water in the UIB. These questions are on the margins of current thinking and investigation and are clustered into 14 themes, covering three overarching topics of "governance, policy, and sustainable solutions", "socioeconomic processes and livelihoods", and "integrated Earth System processes". Raising awareness of these cutting‐edge knowledge gaps and opportunities will hopefully encourage researchers, funding bodies, practitioners, and policy makers to address them. Plain Language Summary: Huge populations of people across Pakistan, India, China, and Afghanistan depend on river systems originating from the mountainous Upper Indus Basin (UIB) region. These river systems are fed by snow and glacier melt and rainfall. However, demand for freshwater is growing due to population growth, industrialization, urban development, etc, and climate change also poses a serious threat to the water supply. These two pressures pose considerable adaptation changes. The strong connections between water resources, climate change, and human activities within this region, therefore, suggest that a multi‐disciplinary research approach combining social and natural/environmental sciences is required for successful adaptation to ongoing and future climate change. Here we use a 'horizon scanning' technique to identify the Top 100 questions related to the most pressing knowledge gaps and research priorities in social and natural sciences on climate change and water in the UIB. Raising awareness of these cutting‐edge knowledge gaps and opportunities will hopefully encourage researchers, funding bodies, practitioners, and policy makers to address them and help inform future water management, climate plans, and development policy in the UIB. Key Points: The Top 100 research questions on climate change and water in the Upper Indus Basin in the social and natural sciences are identifiedMany questions are cross‐disciplinary given the strong linkages between climate, water, and human activities in the Upper Indus BasinQuestions are identified using horizon scanning, which is a technique used to identify knowledge gaps relevant to emerging challenges [ABSTRACT FROM AUTHOR]

Background: Multiple Sclerosis (MS) is a growing global health challenge affecting nearly 3 million people. Progress has been made in the understanding and treatment of MS over the last several decades, but cures remain elusive. The National MS Society is focused on achieving cures for MS. Objectives: Cures for MS will be hastened by having a roadmap that describes knowledge gaps, milestones, and research priorities. In this report, we share the Pathways to Cures Research Roadmap and recommendations for strategies to accelerate the development of MS cures. Methods: The Roadmap was developed through engagement of scientific thought leaders and people affected by MS from North America and the United Kingdom. It also included the perspectives of over 300 people living with MS and was endorsed by many leading MS organizations. Results: The Roadmap consist of three distinct but overlapping cure pathways: (1) stopping the MS disease process, (2) restoring lost function by reversing damage and symptoms, and (3) ending MS through prevention. Better alignment and focus of global resources on high priority research questions are also recommended. Conclusions: We hope the Roadmap will inspire greater collaboration and alignment of global resources that accelerate scientific breakthroughs leading to cures for MS. [ABSTRACT FROM AUTHOR]

Abstract Background Hemophilia gene therapy is a rapidly evolving therapeutic approach in which a number of programs are approaching clinical development completion. Objective The aim of this study was to evaluate knowledge and perceptions of a variety of health care practitioners and scientists about gene therapy for hemophilia. Methods This survey study was conducted February 1 to 18, 2019. Survey participants were members of the ISTH, European Hemophilia Consortium, European Hematology Association, or European Association for Hemophilia and Allied Disorders with valid email contacts. The online survey consisted of 36 questions covering demographic information, perceptions and knowledge of gene therapy for hemophilia, and educational preferences. Survey results were summarized using descriptive statistics. Results Of the 5117 survey recipients, 201 responded from 55 countries (4% response rate). Most respondents (66%) were physicians, and 59% were physicians directly involved in the care of people with hemophilia. Among physician respondents directly involved in hemophilia care, 35% lacked the ability to explain the science of adeno‐associated viral gene therapy for hemophilia, and 40% indicated limited ability or lack of comfort answering patient questions about gene therapy for hemophilia based on clinical trial results to date. Overall, 75% of survey respondents answered 10 single‐answer knowledge questions correctly, 13% incorrectly, and 12% were unsure of the correct answers. Conclusions This survey highlighted knowledge gaps and educational needs related to gene therapy for hemophilia and, along with other inputs, has informed the development of “Gene Therapy in Hemophilia: An ISTH Education Initiative.”

New product development strategies, such as set-based concurrent engineering design (SBCED) or set-based design (SBD), have demonstrated improved ways to address knowledge gaps in alternate design concepts prior to the decision to select a single concept for development. Most of the corpus in this field addresses engineering product development that relies on systems and subsystems with years of prior experience in testing, development, and operation. These often have known or existing solutions, and use state-of-the-art (SOA), or near SOA technology. In addition, most papers do not dive into the details of how knowledge was attained to rapidly close critical knowledge gaps. This paper attempts to explain how a research-based method to construct knowledge can accelerate the knowledge capture critical for developing solutions to extremely challenging problems. This rapid R&D methodology enables a rapid acquisition of critical knowledge to understand potential failure modes of concepts in a set-based way. Thus, it enables intelligent decisions for the selection of the final concept as well as the continuous maturation of parallel concepts. The continuous, parallel maturation of multiple concepts enables effective off-ramps in the design process as requirements and new knowledge arise in the course of the development program, without incurring excessive rework, cost growth, and schedule creep. The goal of this paper is to describe a method that accelerates the generation of critical knowledge early in the conceptual design phase, as a way to close knowledge gaps quickly, and thus enable intelligent design decisions and concept selections early in the product development cycle. The methodological descriptions are illustrated with case examples from NASA technology development.

Abstract River systems originating from the Upper Indus Basin (UIB) are dominated by runoff from snow and glacier melt and summer monsoonal rainfall. These water resources are highly stressed as huge populations of people living in this region depend on them, including for agriculture, domestic use, and energy production. Projections suggest that the UIB region will be affected by considerable (yet poorly quantified) changes to the seasonality and composition of runoff in the future, which are likely to have considerable impacts on these supplies. Given how directly and indirectly communities and ecosystems are dependent on these resources and the growing pressure on them due to ever‐increasing demands, the impacts of climate change pose considerable adaptation challenges. The strong linkages between hydroclimate, cryosphere, water resources, and human activities within the UIB suggest that a multi‐ and inter‐disciplinary research approach integrating the social and natural/environmental sciences is critical for successful adaptation to ongoing and future hydrological and climate change. Here we use a horizon scanning technique to identify the Top 100 questions related to the most pressing knowledge gaps and research priorities in social and natural sciences on climate change and water in the UIB. These questions are on the margins of current thinking and investigation and are clustered into 14 themes, covering three overarching topics of “governance, policy, and sustainable solutions”, “socioeconomic processes and livelihoods”, and “integrated Earth System processes”. Raising awareness of these cutting‐edge knowledge gaps and opportunities will hopefully encourage researchers, funding bodies, practitioners, and policy makers to address them.

BackgroundSevere combined immunodeficiency (SCID) is a group of life-threatening genetic disorders responsible for severe dysfunctions of the immune system. Despite the expansion of newborn screening in the U.S., there are gaps in healthcare providers' knowledge of SCID.MethodsWe recruited 277 U.S. healthcare providers for an online survey. The survey assessed providers' experience with SCID patients, knowledge about SCID, and needs and preferred formats for SCID-related informational resources. We examined differences between providers who have seen 2 or more patients with SCID (SCID provider group) and those who have seen 0–1 SCID patients (non-SCID provider group).ResultsOverall, 210 (75.8%) providers were included in the non-SCID provider group, and 121 (57.6%) of these providers were pediatricians. Compared to the SCID provider group, non-SCID provider group reported lower mean rating of SCID knowledge (x̄ = 4.8 vs. x̄ = 8.6, p < 0.0001) and higher informational needs. The largest informational needs identified by the non-SCID provider group were “understanding specific type of SCID” and “understanding what to expect across the lifespan.” In the SCID provider group, the highest rated informational need was “family support referrals.” Participants in the non-SCID provider group identified scientific publications and websites as preferred formats, with some variation between medical specialties.ConclusionBased on their experience with treating SCID patients, providers have varying levels of SCID knowledge and different informational needs. For providers who have encountered few SCID patients, informational needs start early, usually immediately after receiving a positive newborn screening result. These findings provide useful direction for the development and preferred outlets for receiving SCID-related information, with some variations between different types of providers. Results from this study will serve as a guide for creating relevant and accessible SCID resources for providers who can utilize them to improve care for SCID patients.

Simulation models of social processes may require data that are not readily available, have low accuracy, are incomplete or biased. The paper presents a formal process for collating, assessing, selecting, and using secondary data as part of creating, validating, and documenting an agent-based simulation model of a complex social process, in this case, asylum seekers' journeys to Europe. The process starts by creating an inventory of data sources, and the associated metadata, followed by assessing different aspects of data quality according to pre-defined criteria. As a result, based on the typology of available data, we are able to produce a thematic map of the area under study, and assess the uncertainty of key data sources, at least qualitatively. We illustrate the process by looking at the data on Syrian migration to Europe in 2011-21. In parallel, successive stages of the development of a simulation model allow for identifying key types of information which are needed as input into empirically grounded modelling analysis. Juxtaposing the available evidence and model requirements allows for identifying knowledge gaps that need filling, preferably by collecting additional primary data, or, failing that, by carrying out a sensitivity analysis for the assumptions made. By doing so, we offer a way of formalising the data collection process in the context of model-building endeavours, while allowing the modelling to be predominantly question-driven rather than purely data-driven. The paper concludes with recommendations with respect to data and evidence, both for modellers, as well as model users in practice-oriented applications., Competing Interests: No competing interests were disclosed., (Copyright: © 2024 Nurse S et al.)

Background: Testicular cancer poses a substantial health burden globally, and early detection through testicular self-examination (TSE) is vital for improving prognosis. The study aims to assess the perception, awareness, knowledge, and factors associated with TSE among Saudi nursing students., Materials and Methods: A structured questionnaire was distributed to 418 participants. Data analysis included descriptive statistics, Chi-square tests, and t-tests., Results: On average, the participants' self-confidence in their knowledge to perform TSE was 6.18 (±3.3) out of 10. The majority of participants held misconceptions about TSE, perceiving it as painful (91.86%) and embarrassing (52.39%). The mean of correct awareness and knowledge levels of participants about steps in performing TSE was 9.2 (SD = ±3.6) out of 21. On average, the correct perception of TC and TSE was 11.73 (±4.11) out of 20. Significant relationships emerged between TSE performance and factors such as being married ( P = 0.043), having good or less health status ( P = 0.015), being a tobacco user ( P = 0.039), having a medical problem with testicles ( P = 0.005) or family history of TC ( P = 0.007), has been learned about TSE ( P = 0.002), high-grade point average ( P = 0.012), had high self-confidence to perform TSE ( P = 0.033), and had correct perception about TC and TSE ( P = 0.037), had correct awareness about TSE ( P = 0.021), had motivated factors that influencing to practice of TSE ( P = 0.003), and had correct awareness and knowledge levels of participants about steps in performing TSE ( P = 0.002)., Conclusion: The study underscores the need for targeted educational interventions and curriculum enhancements to dispel misconceptions, improve awareness, and promote accurate TSE practices among nursing students. Public health campaigns are recommended to address barriers and normalize TSE., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Journal of Education and Health Promotion.)

Background: Primary brain tumors (PBTs) pose a significant health challenge, affecting patients and their caregivers. While early integration of palliative care (PC) has shown benefits in advanced cancer, its integration for PBT patients, particularly glioblastoma (GBM) patients, remains complex. We hypothesized that our previous PC integration efforts may have failed due to knowledge-gaps and misconceptions among patients, caregivers, and providers., Objective: This study aimed to identify knowledge gaps and misconceptions about PC among patients with primary brain tumors (PBTs), their caregivers, and their medical providers., Method: An electronic survey was distributed to PBT patients, caregivers, and medical providers, that included questions regarding PC from the Health Information National Trends Survey (HINTS). Survey responses were analyzed; comparisons were made between the 3 groups as well as the general population., Results: Of 141 respondents (59 patients, 57 caregivers, and 25 providers), each group held perspectives on PC differing from the general population. While all groups had an improved understanding of PC's role in symptom management, uncertainty persisted among patients and caregivers regarding life-prolonging treatment and certain PC goals like caregiver support or end-of-life care., Conclusion: Understanding gaps in knowledge and perceptions of PC among PBT patients and caregivers is crucial for effective intervention, with caregivers playing a vital role in advocating for PC. Future research should explore factors influencing these perceptions and development of targeted education to improve early PC referrals for patients with PBTs., Competing Interests: Declaration of Conflicting InterestThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Mary Lou Affronti has received research support from TerSera who provided rolapitant and funding for an investigator-initiated Phase II study (Pro00076418). TerSera’s role for this investigator-initiated study was to review/approve the protocol and manuscripts. No protocol writing or data analysis was conducted by TerSera. Mary Lou Affronti is Vice Chair and member of Multinational Association for Supportive Care in Cancer (MASCC) Antiemetic study group and on the 2023 Antiemetic Guideline Consensus Committee (Chaired the Patient Antiemetic Guideline committee; Member of Integrative/Non-pharmacological Antiemetic Guideline committee) without financial compensation. Dr Affronti is associated with 2023-5 Society for Neuro-Oncology serving as Board of Directors representative for APPs/Allied health and receives no financial compensation. Christopher A. Jones serving on Board of Directors representative for the American Academy of Hospice and Palliative Medicine. All other authors have no relevant financial or non-financial interests to disclose.

Background The aim of the research is to determine the existing knowledge, perceived practices, and attitudes toward the recombinant Zoster vaccine among family medicine residents (FMR) included in the medical profession. The present study aims to narrow down the identified gap in knowledge and develop vaccinations that will assist the targeted deme to eradicate zoster and the aftermaths that accompany it. Methods This research utilizes a descriptive cross-sectional survey design to assess the knowledge, practices, and attitudes of FMR toward the zoster vaccine in Riyadh, Saudi Arabia. By quantifying data at a specific point in time, this design allows for a detailed examination of the current status across various levels of residency programs. Participants from different institutions are interviewed simultaneously, enabling a thorough study of the targeted population group. The study includes 154 FMR from three different levels (R1, R2, R3) enrolled in residency programs at various institutions in Riyadh, Saudi Arabia. These participants were selected from a group of individuals invited to share their prior knowledge, habits, and beliefs regarding the recombinant Zoster vaccine. The study offers detailed statistical insights into demographics, vaccination attitudes, and knowledge among healthcare professionals. Key findings highlight diverse recommendations for different adult groups, the prevalence of vaccine availability, and the main sources of immunization information. Results The study found diverse recommendations for vaccination among different adult groups, with mean recommendations ranging from 2.50 to 2.94. Nearly all respondents (96.8%) reported having the vaccine available at their place of practice. However, knowledge gaps were evident, particularly concerning vaccination timing and specific requirements, highlighting the need for targeted education and clearer guidelines in vaccination practices among healthcare providers. Conclusion The study highlights the nuanced vaccination recommendations among healthcare professionals, particularly for different adult populations, and the availability of varicella-zoster virus (VZV) vaccines. The reliance on diverse information sources underscores the need for targeted educational efforts to ensure accurate and consistent immunization practices across healthcare settings. Addressing uncertainties and promoting informed decision-making can enhance vaccination uptake and patient care outcomes in clinical practice., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. King Fahad Medical City Institutional Review board issued approval 23-300. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Alahmari et al.)

Detailed information on species distributions is crucial for answering central questions in biogeography, ecology, evolutionary biology and conservation. Millions of species occurrence records have been mobilized via international data-sharing networks, but inherent biases, gaps and uncertainties hamper broader application. In my PhD thesis, I presented the first comprehensive analyses of global patterns and drivers of these limitations across different taxonomic groups and spatial scales. Integrating 300 million occurrence records for terrestrial vertebrates and plants with comprehensive taxonomic databases, expert range maps and regional checklists, I demonstrated extensive taxonomic, geographical and temporal biases, gaps and uncertainties. I identified key socio-economic drivers of data bias across different taxonomic groups and spatial scales. The results of my dissertation provide an empirical baseline for effectively accounting for data limitations in distribution models, as well as for prioritizing and monitoring efforts to collate additional occurrence information.

El presente artículo corresponde a la segunda parte de la investigación: Una metodología para la identificación y cierre de brechas de conocimiento en el capital humano para una organización innovadora basada en conocimiento; la primera parte de la investigación se centró en la identificación de requerimientos de este tipo de organización y la revisión bibliográfica de metodologías similares. Al no hallarse en la búsqueda una metodología que reuniera todos los elementos requeridos, la investigación continuo con esta segunda parte que tiene como objetivo la propuesta del diseño de una metodología ideal para la Corporación de Ciencia y Tecnología para el Desarrollo de la Industria Naval, Marítima y Fluvial (Cotecmar), empresa caso de estudio. La propuesta fue diseñada adaptando algunos elementos encontrados en las metodologías evaluadas, e incorporando otros nuevos obteniéndose como resultado una metodología dinámica compuesta de técnicas y herramientas para la recolección, tratamiento y presentación de datos, que permiten con rapidez la identificación de brechas de conocimiento mediante la clasificación de este en las categorías Medular, Organizacional y TIC´s; y en los niveles Aprendiz, Conocedor, Experto y Maestro; adicional, presenta estrategias para el seguimiento y cierre de brechas. English abstract This article corresponds to the second part of the research: A methodology for the identification and closing of knowledge gaps in human capital for an innovative knowledge-based organization; The first part of the research focused on the identification of requirements of this type of organization and the bibliographic review of similar methodologies. As in the search was not found a methodology that met all the required elements, the investigation continued with this second part that aims to propose the design of an ideal methodology for the Corporation of Science and Technology for the Development of the Naval, Maritime Industry and Fluvial (Cotecmar), a case study company. The proposal was designed by adapting some elements found in the evaluated methodologies, and incorporating new ones, obtaining as a result a dynamic methodology composed of techniques and tools for the collection, treatment and presentation of data, which allow quickly the identification of knowledge gaps through the classification of this in the categories Medullary, Organizational and ICT's; and at the levels Apprentice, Knowledgeable, Expert and Master; Additionally, it presents strategies for the follow-up and closure of gaps.

Concerns persist over the potential for the fragmented media environment to promote motivation-based political knowledge gaps between those who are interested in politics and those who are not. Yet, there is also evidence that the Internet can provide opportunities for individuals to incidentally encounter and learn from news, which may decrease these knowledge gaps. The current study tests this possibility using two, two-wave panel surveys of adults in the United States conducted during the 2012 and 2016 presidential elections. Across two distinct electoral contexts, we find evidence that incidental exposure to online news and political information promotes learning about presidential candidates' policy positions over the course of the campaign. In addition, the data suggest the least politically interested benefit the most from this incidental exposure, as they see the largest gains in political knowledge. These findings indicate that opportunities to learn via incidental exposure have the potential to reduce motivation-based knowledge gaps. [ABSTRACT FROM AUTHOR]

Aim/Purpose: The purpose of this paper is to address the issue of gaps in students' knowledge at the time they enter a comprehensive Information Systems capstone course. This problem of knowledge gaps was exacerbated by the forced remote learning and isolation caused by the COVID-19 pandemic. The aim was to find a technique that would identify and fill those gaps. Ideally, the method would also reinforce the students' interpersonal soft skills. Background: Many universities have a capstone course where students may apply their knowledge from the curriculum to a project, and they are evaluated on their retention of knowledge from the core classes. Over the past two years, students have experienced course interruptions and modifications due to the pandemic, resulting in learning gaps on topics covered in the core courses. Depending on the project's scope and curriculum, this may prevent students from conversing on many essential concepts during the capstone course. By requiring students to create "Teach Back" tutorials on materials from their core courses, faculty may ensure that the key concepts are discussed multiple times within the curriculum. Methodology: We present a case study to identify key concepts and compare cohort results before and after implementation. Contribution: A process for identifying potential knowledge gaps is identified, and a method to repeatedly expose students to concepts is introduced. Findings: There were improvements to the overall capstone scores after the tutorial implementation. While many factors influence changes in scores across cohorts, the initial findings are promising, supporting the concept that teaching back helps to close knowledge gaps. Recommendations for Practitioners: Faculty should collaborate to identify knowledge areas that need to be reinforced later in their students' academic careers. Teaching back essential concepts that may not be prioritized in implementing a capstone project ensures a repeated exposure to the identified concepts. Recommendations for Researchers: There needs to be a priority to teach students to be lifelong learners and to teach the skills needed to share their knowledge with future coworkers. There needs to be more research into a pedagogy that builds these essential soft skills within our curriculum. Finally, research into alumni feedback on course topics and pedagogy is needed. Impact on Society: Introducing pedagogy that improves both knowledge and soft skills, this research looks to build individuals who will learn independently and be able to communicate with and improve others. Future Research: There needs to be additional research to study the changes in technical knowledge before and after Teach Back, the consequences of elective sequencing, the consideration of elective versus required courses, and the use of Teach Back to capture student knowledge gained from completing diverse electives prior to the capstone course. [ABSTRACT FROM AUTHOR]

Artificial Intelligence (AI) is set to redefine how farming occurs. Throughout history examples of technological advances have shown that less labour has been required on a farm while at the same time increasing the output of food production. However, an interesting observation is that as technology has improved the farming process and replaced workers, it has opened a new avenue known as diversification. This paper focuses specifically on the impact that AI will have on the future of farming in the European sector. The literature brings to light common trends that technological innovations have always decreased the number of workers required in the farming process while at the same time maximising efficiency. AI will also follow the same trend, however, instead of eliminating workers in the farming process soon, the present observations show that farmers will still require workers to work alongside AI. The reason for increased investments in AI is due to research data showing a decline in population growth in Europe and the struggling profitability of farmers. Thereby analysts believe that a labour shortage will occur, and industries will struggle to fill those skills requirements. A qualitative summary was done on artificial intelligence technologies' development impact on the labour of the agricultural sector of Europe. [ABSTRACT FROM AUTHOR]

Background: Strategies involved in the prevention and management of sickle cell disease include premarital genotype screening and counselling as well as efforts at increasing the knowledge of the population about the condition. Methodology: This is a cross-sectional descriptive study which assessed the knowledge of sickle cell disease and premarital genotype screening, attitudes towards screening and factors associated with uptake of premarital genotype screening among 326 final year students of the University of Ibadan, Oyo State, Nigeria. Results: Respondents were within the age range of 18-24 with a mean age of 23. Majority of the respondents had AA genotype (68.71%). Only 15.95% of the respondents had good knowledge of sickle cell disease. Mean knowledge score was 14 out of 26 with a standard deviation of 4.31. 75.77% of the respondents had good knowledge of premarital genotype screening. 76.07% of the respondents had good attitudes to premarital genotype screening. Mean attitude score was 9.5 out of 12 with a standard deviation of 2.15. Respondents' current level of study (P=0.()()0) and marital status (P=0.042) were significantly associated with knowledge of sickle cell disease. There was significant association between knowledge of sickle cell disease and knowledge of premarital genotype screening (Fisher's P= 0.000). Knowledge of premarital genotype screening was significantly associated with respondents' current level of study (P=0.004) and attitudes to premarital genotype screening (Fisher's P= 0.000). Conclusion: Significant knowledge gaps were identified in the study population. There is need for continuous assessment of knowledge gaps and educational intervention in order to decrease the incidence of sickle cell disease. [ABSTRACT FROM AUTHOR]

We describe the development of the Research Agenda of the Dutch Society for Plastic Surgery, supported and democratically created by plastic surgeons, patients, and other stakeholders. The agenda contains the 10 most relevant knowledge gaps encountered in clinical practice, as prioritized by the abovementioned groups. The aim is to stimulate national collaborations and research networks to initiate trials to answer these knowledge gaps. The agenda will be renewed periodically to stay relevant. We encourage other national and international associations to develop a research agenda within their field, and intensify their research network and improve research quality. [ABSTRACT FROM AUTHOR]

We investigate the often-stated, but disputed claim in the political science and political communication literature that increasing media choice widens inequalities in political knowledge. The assumption is that in a high-choice media environment, the politically interested will consume more news while the uninterested will avoid such content, leading, in turn, to widening differences in political knowledge. Although previous studies show that high media choice increases political knowledge gaps in the United States, comparative longitudinal evidence is currently lacking. To fill this gap, we draw on data from four rounds of the Comparative Study of Electoral Systems. Overall, we do not find general support for the high-choice knowledge gap thesis. In most countries, there is no indication that inequality in political knowledge has increased over time. Building on recent insights from political communication research, we question key assumptions of the high choice knowledge gap thesis. [ABSTRACT FROM AUTHOR]

Synthetic gene drives are transgenic constructs that aim to bias heredity and thereby influence the characteristics and fate of populations regarding abundance and evolution. Aside from irreversible effects in ecosystems that could be triggered by the release of a gene drive, research on confinable drives or even the reversibility of gene drives is underway and shows first success under laboratory conditions. However, their effectiveness under realistic conditions is not entirely clear unless first test releases have taken place. Since a potentially irreversible intervention into ecosystems is created, a prospective assessment is needed. We present an approach of prospective ecological vulnerability analysis for the proposed control of the invasive pest Drosophila suzukii by using gene drives. The analysis considers the accidental spread of the gene drive to the native habitat of Drosophila suzukii, with a focus on Japan. It contains a mapping of potential impacts as a consequence of the suppression of the insect. Multiple cascading effects were identified including the potential spread of the gene drive in geographic range or potential hybridization with non-target species. Determining the vulnerability of an ecosystem requires information regarding specific characteristics at different organizational levels. The vulnerability analysis of an affected ecosystem will initially serve to identify gaps in knowledge. Reducing complexity and breaking down the potential events that might arise from a gene drive population suppression enables to better understand endpoints i.e. concrete effects. Three potential effects have been selected for a specific analysis of the vulnerability of populations and species. A high vulnerability was obtained for the suppression of non-target (native) populations of Drosophila suzukii as well as for a decrease in specialized parasitoid abundance. The paper proposes the outline of a comprehensive prospective approach to understand the susceptibility of an ecosystem to unintended and irreversible harm.

One of the best ways to share and disseminate biodiversity information is through the digitization of data and making it available via online databases. The rapid growth of publicly available biodiversity data is not without problems which may decrease the utility of online databases. In this study we analyze taxonomic, geographic and temporal data gaps, and bias related to existing data on selected marine invertebrate occurrences along the coastline of two African countries, Mozambique and São Tomé and Príncipe. The final marine invertebrate dataset comprises of 19.910 occurrences, but 32% of the original dataset occurrences were excluded due to data gaps. Most marine invertebrates in Mozambique were collected in seagrasses, whereas in São Tomé and Príncipe they were mostly collected offshore. The dataset has a temporal coverage from 1816 to 2019, with most occurrences collected in the last two decades. This study provides baseline information relevant to a better understanding of marine invertebrate biodiversity data gaps and bias in these habitats along the coasts of these countries. The information can be further applied to complete marine invertebrate data gaps contributing to design informed sampling strategies and advancing refined datasets that can be used in management and conservation plans in both countries.

Current limitations in the understanding and control of antimicrobial resistance (AMR) in Canada are described through a comprehensive review focusing on: (1) treatment optimization; (2) surveillance of antimicrobial use and AMR; and (3) prevention of transmission of AMR. Without addressing gaps in identified areas, sustained progress in AMR mitigation is unlikely. Expert opinions and perspectives contributed to prioritizing identified gaps. Using Canada as an example, this review emphasizes the importance and necessity of a One Health approach for understanding and mitigating AMR. Specifically, antimicrobial use in human, animal, crop, and environmental sectors cannot be regarded as independent; therefore, a One Health approach is needed in AMR research and understanding, current surveillance efforts, and policy. Discussions regarding addressing described knowledge gaps are separated into four categories: (1) further research; (2) increased capacity/resources; (3) increased prescriber/end-user knowledge; and (4) policy development/enforcement. This review highlights the research and increased capacity and resources to generate new knowledge and implement recommendations needed to address all identified gaps, including economic, social, and environmental considerations. More prescriber/end-user knowledge and policy development/enforcement are needed, but must be informed by realistic recommendations, with input from all relevant stakeholders. For most knowledge gaps, important next steps are uncertain. In conclusion, identified knowledge gaps underlined the need for AMR policy decisions to be considered in a One Health framework, while highlighting critical needs to achieve realistic and meaningful progress.

Abstract Federally designated wilderness areas in the US are mandated to fulfill social and ecological goals. Long‐term monitoring is key to this mandate, yet is seldom consistent across boundaries. Our purpose is to compile literature and data to examine the utility of a strategic forest inventory for meeting wilderness management objectives and for enabling coordinated interagency responses to boundary‐crossing challenges (e.g., pollution, wildfires, plant invasions, global changes). We provide examples from a national forest inventory (NFI), which provides nationally consistent information that helps stakeholders comply with protected‐areas policy, reduce risks to public safety, define economic opportunities, guide conservation efforts and forecast key ecological processes. For example, the NFI has helped detect long‐distance air‐pollution, document high‐elevation whitebark pine declines and evaluate the risk of wilderness fires spreading to adjacent lands and private property. We identify opportunities to improve monitoring by expanding existing measurements of nonforest ecosystems and linking supplemental monitoring efforts to the existing framework. Though the NFI alone cannot fulfill all monitoring functions, strategic monitoring enables effective wilderness management by revealing socioecological feedbacks between human communities and the wildlands on which they depend.

Objective: This study aimed to explore current attitudes towards sun protection, and sun-seeking behaviour among young Australian adolescents. It was done as part of a larger project aiming to develop a digital resource to support young people in making informed sun-health decisions. Results: Ten (4 male, 6 female) adolescents (12–13 years of age) living in Perth (Western Australia) were recruited through a social media-based strategy. Each participant engaged in a semi-structured telephone interview which explored their sun-health decision-making, with interview transcripts assessed qualitatively using NVivo. Three major themes (and eight sub-themes) were identified: (1) 'personal sun health considerations'; (2) 'attitudes towards sun protection'; and (3) 'recommendations'. The importance of sun protection was appreciated by participants. However, females were more diligent in the use of sun protection while males were indifferent. Behaviours were influenced by parental input, the school environment and engagement in sport. Adolescents had limited knowledge of the UV Index and its implications for sun protection, and the health importance of sun-derived vitamin D. Overall, the importance of sun protection was acknowledged but did not consistently translate into sun protective behaviours. [ABSTRACT FROM AUTHOR]