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105. Le insegne ed i protocolli d’ascesa da Teodosio I a Giustino II: funzionalità e significatività dei segni dell’eccellenza del rango

Author

Antonio Pio di cosmo

Subjects
History of the Greco-Roman World, DE1-100, Greek language and literature. Latin language and literature, PA
Abstract

Il presente contributo analizza il ruolo giocato dai segni del potere imperiale ed in particolare delle insegne nei riti di elezione fra IV e VI secc.. Questa ricerca applica le conoscenze in materia archeologica, antropologica e storica. Si racconta il rituale di elezione e si risolvono le questioni circa i problemi di rappresentazione dell’augusto nelle cerimonie d’ascesa. In questo modo si vagliano le strategie di comunicazione che modellano i protocolli di creazione degli augusti.

Published
2023
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106. Morphologic and genic effects of waste pollution on the reproductive physiology of Paracentrotus lividus lmk: a mesocosm experiment

Author

Francesca Glaviano, Serena Federico, Bruno Pinto, Maissa Gharbi, Tania Russo, Anna Di Cosmo, Gianluca Polese, Maria Costantini, and Valerio Zupo

Subjects
dissolved organic compounds, recirculated aquaculture system, gene expression, larvae, sea urchin, Physiology, QP1-981
Abstract

A considerable amount of coastal contamination is caused by wastes deriving from household and the degradation and the metabolism of plants and animals, even if our attention is commonly focused on industrial pollutants and contaminants. Waste pollutants are mainly represented by highly diluted soluble compounds and particles deriving from dead organisms. This complex combination, consisting of suspended particles and dissolved nutrients, has a significant impact on coastal planktonic and benthic organisms, also playing an active role in the global cycles of carbon. In addition, production practices are nowadays shifting towards recirculated aquaculture systems (RAS) and the genic responses of target organisms to the pollution deriving from animal metabolism are still scarcely addressed by scientific investigations. The reservoir of organic matter dissolved in the seawater is by far the least understood if compared to that on land, cause only a few compounds have been identified and their impacts on animals and plants are poorly understood. The tendency of these compounds to concentrate at interfaces facilitates the absorption of dissolved organic compound (DOC) onto suspended particles. Some DOC components are chemically combined with dissolved metals and form complexes, affecting the chemical properties of the seawater and the life of the coastal biota. In this research, we compared the reproductive performances of the common sea urchin Paracentrotus lividus cultured in open-cycle tanks to those cultured in a recirculating aquaculture system (RAS), where pollution progressively increased during the experiment due to animal escretions. Sea urchins were cultured for 7 months under these two conditions and their gametes were collected. Embryos resulting by in vitro fertilization were analyzed by Real Time qPCR to identify possible effects of pollution-induced stress. The fertility of sea urchins was evaluated, as well as the gonadosomatic indices and the histological features of gonads. Our results indicate that pollution due to excess of nutrients, event at sub-lethal concentrations, may hardly impact the reproductive potential of this key species and that chronic effects of stress are revealed by the analyses of survival rates and gene expression.

Published
2023
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108. The Use of Isoflurane and Adjunctive Magnesium Chloride Provides Fast, Effective Anaesthetization of Octopus vulgaris

Author

Anna Di Cosmo, Valeria Maselli, Emanuela Cirillo, Mariangela Norcia, Heethaka K. S. de Zoysa, Gianluca Polese, and William Winlow

Subjects
general anaesthetics, Octopus vulgaris, isoflurane, magnesium chloride, depth of anaesthesia, stress reduction, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract

A wide variety of substances have been used to anaesthetise invertebrates, but many are not anaesthetics and merely incapacitate animals rather than preventing pain. In essence, the role of an ideal general anaesthetic is to act as a muscle relaxant, an analgesic, an anaesthetic, and an amnesic. To achieve all these properties with a single substance is difficult, and various adjuvants usually need to be administered, resulting in a cocktail of drugs. In a clinical setting, the vast majority of patients are unaware of surgery being carried out and have no memory of it, so they can claim to have felt no pain, but this is much more difficult to demonstrate in invertebrates. Here, we show that 1% MgCl2, a muscle relaxant, is a useful adjuvant for the clinical anaesthetic isoflurane on Octopus vulgaris when applied alone in seawater for 10 min before the clinical anaesthetic. After this, full anaesthesia can be achieved in 5 min using 1% isoflurane insufflated into the saline still containing MgCl2. Full recovery takes place rapidly in about 10 to 15 min. The depth of anaesthesia was monitored using changes in respiratory rate, chromatophore pattern, and withdrawal movements of the arms and siphon. This methodology reduces stress on the animal and minimises the quantity of anaesthetic used.

Published
2023
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109. A Pedagogical Intrinsic Approach to Relative Entropies as Potential Functions of Quantum Metrics: the $q$-$z$ Family

Author

Ciaglia, Florio M., Di Cosmo, Fabio, Laudato, Marco, Marmo, Giuseppe, Mele, Fabio M., Ventriglia, Franco, and Vitale, Patrizia

Subjects
Quantum Physics, Computer Science - Information Theory, High Energy Physics - Theory, Mathematical Physics
Abstract

The so-called $q$-z-\textit{R\'enyi Relative Entropies} provide a huge two-parameter family of relative entropies which includes almost all well-known examples of quantum relative entropies for suitable values of the parameters. In this paper we consider a log-regularized version of this family and use it as a family of potential functions to generate covariant $(0,2)$ symmetric tensors on the space of invertible quantum states in finite dimensions. The geometric formalism developed here allows us to obtain the explicit expressions of such tensor fields in terms of a basis of globally defined differential forms on a suitable unfolding space without the need to introduce a specific set of coordinates. To make the reader acquainted with the intrinsic formalism introduced, we first perform the computation for the qubit case, and then, we extend the computation of the metric-like tensors to a generic $n$-level system. By suitably varying the parameters $q$ and $z$, we are able to recover well-known examples of quantum metric tensors that, in our treatment, appear written in terms of globally defined geometrical objects that do not depend on the coordinates system used. In particular, we obtain a coordinate-free expression for the von Neumann-Umegaki metric, for the Bures metric and for the Wigner-Yanase metric in the arbitrary $n$-level case., Comment: 50 pages, 1 figure

Published
2017
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110. Hamilton-Jacobi Theory and Information Geometry

Author

Ciaglia, Florio M., Di Cosmo, Fabio, and Marmo, Giuseppe

Subjects
Mathematical Physics
Abstract

Recently, a method to dynamically define a divergence function $D$ for a given statistical manifold $(\mathcal{M}\,,g\,,T)$ by means of the Hamilton-Jacobi theory associated with a suitable Lagrangian function $\mathfrak{L}$ on $T\mathcal{M}$ has been proposed. Here we will review this construction and lay the basis for an inverse problem where we assume the divergence function $D$ to be known and we look for a Lagrangian function $\mathfrak{L}$ for which $D$ is a complete solution of the associated Hamilton-Jacobi theory. To apply these ideas to quantum systems, we have to replace probability distributions with probability amplitudes., Comment: 8 pages

Published
2017
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114. The 852/3 CE Mount Churchill eruption: examining the potential climatic and societal impacts and the timing of the Medieval Climate Anomaly in the North Atlantic region

Author

H. Mackay, G. Plunkett, B. J. L. Jensen, T. J. Aubry, C. Corona, W. M. Kim, M. Toohey, M. Sigl, M. Stoffel, K. J. Anchukaitis, C. Raible, M. S. M. Bolton, J. G. Manning, T. P. Newfield, N. Di Cosmo, F. Ludlow, C. Kostick, Z. Yang, L. Coyle McClung, M. Amesbury, A. Monteath, P. D. M. Hughes, P. G. Langdon, D. Charman, R. Booth, K. L. Davies, A. Blundell, and G. T. Swindles

Subjects
Environmental pollution, TD172-193.5, Environmental protection, TD169-171.8, Environmental sciences, GE1-350
Abstract

The 852/3 CE eruption of Mount Churchill, Alaska, was one of the largest first-millennium volcanic events, with a magnitude of 6.7 (VEI 6) and a tephra volume of 39.4–61.9 km3 (95 % confidence). The spatial extent of the ash fallout from this event is considerable and the cryptotephra (White River Ash east; WRAe) extends as far as Finland and Poland. Proximal ecosystem and societal disturbances have been linked with this eruption; however, wider eruption impacts on climate and society are unknown. Greenland ice core records show that the eruption occurred in winter 852/3 ± 1 CE and that the eruption is associated with a relatively moderate sulfate aerosol loading but large abundances of volcanic ash and chlorine. Here we assess the potential broader impact of this eruption using palaeoenvironmental reconstructions, historical records and climate model simulations. We also use the fortuitous timing of the 852/3 CE Churchill eruption and its extensively widespread tephra deposition of the White River Ash (east) (WRAe) to examine the climatic expression of the warm Medieval Climate Anomaly period (MCA; ca. 950–1250 CE) from precisely linked peatlands in the North Atlantic region. The reconstructed climate forcing potential of the 852/3 CE Churchill eruption is moderate compared with the eruption magnitude, but tree-ring-inferred temperatures report a significant atmospheric cooling of 0.8 ∘C in summer 853 CE. Modelled climate scenarios also show a cooling in 853 CE, although the average magnitude of cooling is smaller (0.3 ∘C). The simulated spatial patterns of cooling are generally similar to those generated using the tree-ring-inferred temperature reconstructions. Tree-ring-inferred cooling begins prior to the date of the eruption suggesting that natural internal climate variability may have increased the climate system's susceptibility to further cooling. The magnitude of the reconstructed cooling could also suggest that the climate forcing potential of this eruption may be underestimated, thereby highlighting the need for greater insight into, and consideration of, the role of halogens and volcanic ash when estimating eruption climate forcing potential. Precise comparisons of palaeoenvironmental records from peatlands across North America and Europe, facilitated by the presence of the WRAe isochron, reveal no consistent MCA signal. These findings contribute to the growing body of evidence that characterises the MCA hydroclimate as time-transgressive and heterogeneous rather than a well-defined climatic period. The presence of the WRAe isochron also demonstrates that no long-term (multidecadal) climatic or societal impacts from the 852/3 CE Churchill eruption were identified beyond areas proximal to the eruption. Historical evidence in Europe for subsistence crises demonstrate a degree of temporal correspondence on interannual timescales, but similar events were reported outside of the eruption period and were common in the 9th century. The 852/3 CE Churchill eruption exemplifies the difficulties of identifying and confirming volcanic impacts for a single eruption, even when the eruption has a small age uncertainty.

Published
2022
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116. Clinical nutrition in surgical oncology: Young AIOM-AIRO-SICO multidisciplinary national survey on behalf of NutriOnc research group

Author

Luigi Marano, Federica Marmorino, Isacco Desideri, Ludovico Carbone, Alessandro Rizzo, Viola Salvestrini, Franco Roviello, Saverio Cinieri, Vittorio Donato, Raffaele De Luca, NutriOnc Research Group, Silvia Sofia, Marco Milone, Benedetto Ielpo, Maria Teresa Mita, Silvia Ministrini, Mario Giuffrida, Roberta Tutino, Caterina Baldi, Giampaolo Perri, Anna Stella Lippolis, Chiara Marafante, Giusy Giannandrea, Marco Vito Marino, Letizia Laface, Salomone Di Saverio, Luca Aldrighetti, Nicola de’Angelis, Nick Salimian, Marco Caricato, Gianluca Pellino, Sara Vertaldi, Federica Cipriani, Gabriella Teresa Capolupo, Antonio Costanzo, Letizia Santandrea, Gaetano Gallo, Andrea Belli, Laura Mastrangelo, Fausto Rosa, Nicolò Pecorelli, Graziella Marino, Alessio Giordano, Nicola Cillara, Maria Lemma, Francesco Pata, Federico Cammillini, Gianmario Edoardo Poto, Giulia Grassi, Donato Francesco Altomare, Arcangelo Picciariello, Lorenzo Petagna, Luca Ippolito, Elio Treppiedi, Daniele Delogu, Abdallah Moukachar, Stefano Granieri, Giuseppe Cuticone, Osvaldo Carpineto Samorani, Daniela Rega, Leonardo Solaini, Stefano de Pascale, Francesca Ascari, Michele Manigrasso, Simona Badalucco, Salvatore Paiella, Sara Coppola, Roberta Iadarola, Giovanna Di Meo, Isacco Montroni, Fabio Vistoli, Valentina Ferraro, Edoardo Saladino, Federico Fazio, Roberta Rota, Francesco Orlando, Simone Famularo, Cinzia Bizzoca, Giorgio Dalmonte, Marco Inama, Luigi Verre, Leandro Siragusa, Casoni Pattacini Gianmaria, Michele Benedetti, Nicolò Tamini, Cristian Conti, Giorgio Ammerata, Serena Mantova, Vito Leonardo Pinto, Arianna Corvasce, Giorgio Micheletti, Teresa Perra, Marco Pellicciaro, Marco Materazzo, Michele Zuolo, Emanuele Doria, Antonio Brillantino, Luca Del Prete, Andrea Muratore, Claudio Luciani, Giulia Turri, Fabio Casciani, Giuliani Giuseppe, Graziana Barile, Oldrà Gaia, Valeria Restaino, Simona Deidda, Michele Ammendola, Andrea Fares Bucci, Patrizia Marsanic, Dario Cassetti, Luca Resca, Daniele Fusario, Eleonora Andreucci, Anna Michelotti, Brunella Amoruso, Isabella Franco, Laura Noto, Andrea Spallanzani, Raimondo Calogero Scalia, Teresa Del Giudice, Valeria Merz, Gianmarco Motta, Alessandro Parisi, Mikol Modesti, Antonella Argentiero, Debora Basile, Gianmarco Vannini, Carlotta Ottanelli, Salvatore Corallo, Eufemia Stefania Lutrino, Daniele Rossini, Federica Morano, Luigia Stefania Stucci, Costanza Winchler, Martina Catalano, Andrea Marini, Giuseppe Brisinda, Enrico Sammarco, Martina Carullo, Giandomenico Roviello, Mirko Barone, Maria Grazia Rodriquenz, Giuseppe Tirino, Alessia Amoruso, Anna Russo, Veronica Conca, Laura Orgiano, Sveva Macrini, Giulia Nazzicone, Maria Bensi, Martina Montesano, Emanuela Dell’Aquila, Andrea Sbrana, Beatrice Borelli, Lorenzo Fornaro, Lucrezia Raimondi, Valeria Zurlo, Mattia Garutti, Elena Ongaro, Arianna Pellegrino, Andrea lanese, Laura Bernardini, Alessandra Boccaccino, Patrizia Farina, Federica Buzzacchino, Angelica Petrillo, Ada Taravella, Vittorio Studiale, Paolo Ciracì, Giovanna Lovino, Dora Di Cosmo, Sabrina Montrone, Fabiana Gregucci, Luca Dominici, Alba Fiorentino, Filippo Carannante, Giambattista Siepe, Giampaolo Montesi, Manuele Roghi, Michele Aquilano, Andrea Romei, Ilaria Bonaparte, Roberta Grassi, Emma D’Ippolito, Giulio Frosini, Giuseppina De Marco, Gennaro Giovine, Chiara Mattioli, Ilaria Morelli, Victoria Lorenzetti, Matteo Mariotti, Carolina Orsatti, Vincenzo Troncone, Lorenzo Livi, Antonio Angrisani, Marco Banini, Teresa Di Pietro, Giuseppe Carlo Iorio, Iacopo Cavallo, Cecilia Cerbai, Valerio Nardone, Francesca De Felice, Consuelo Rosa, Giulia Stocchi, Sara Lucidi, Michele Ganovelli, Damiano Dei, Chiara Cascone, Anna Peru, Luisa Caprara, Lucia Angelini, Luca Visani, Giulio Francolini, Beatrice Bettazzi, Francesco Belia, Virginia Boccardi, Simone Serafini, Vincenzo Bottino, Luca Ferrario, Giuseppe Frazzetta, Felice Pirozzi, Gennaro Martines, Francesco Antonio Ciarleglio, Daniele Indiani, Giuliano Barugola, Luca Mazza, and Chiara Guarini

Subjects
clinical nutrition, cancer, malnutrition, nutritional assessment, survey, Nutrition. Foods and food supply, TX341-641
Abstract

Malnutrition is a common condition in cancer patients which is usually associated with functional limitations, as well as increased morbidity and mortality. Based on the support of the young sections of Italian Association of Medical Oncology (AIOM), Italian Association of Radiotherapy and Clinical Oncology (AIRO) and Italian Society of Surgical Oncology (SICO) merged into the NutriOnc Research Group, we performed a multidisciplinary national survey with the aim to define the awareness of nutritional issues among healthcare professionals delivering anticancer care. The questionnaire was organized in four sections, as follows: Knowledge and practices regarding Nutritional Management of cancer patients; Timing of screening and assessment of Nutritional Status; Nutritional Treatment and prescription criteria; Immunonutrition and educational topics. The modules focused on esophagogastric, hepato-bilio-pancreatic and colorectal malignancies. Overall, 215 physicians completed the survey. As regards the management of Nutritional Status of cancer patients, many responders adopted the ERAS program (49.3%), while a consistent number of professionals did not follow a specific validated nutritional care protocol (41.8%), mainly due to lack of educational courses (14.5%) and financial support (15.3%). Nearly all the included institutions had a multidisciplinary team (92%) to finalize the treatment decision-making. Cancer patients routinely underwent nutritional screening according to 57.2% of interviewed physicians. The timing of nutritional assessment was at diagnosis (37.8%), before surgery (25.9%), after surgery (16.7%), before radiochemotherapy (13.5%) and after radiochemotherapy (7%). Most of the responders reported that nutritional status was assessed throughout the duration of cancer treatments (55.6%). An important gap between current delivery and need of nutritional assessment persists. The development of specific and defined care protocols and the adherence to these tools may be the key to improving nutritional support management in clinical practice.

Published
2023
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117. Patient-Reported Outcomes and Return to Intended Oncologic Therapy After Colorectal Enhanced Recovery Pathway

Author

The Italian ColoRectal Anastomotic Leakage (iCral3) study group, Marco Catarci, MD, FACS, Giacomo Ruffo, MD, Massimo Giuseppe Viola, MD, Ferdinando Ficari, MD, Paolo Delrio, MD, Felice Pirozzi, MD, Felice Borghi, MD, Raffaele De Luca, MD, Alberto Patriti, MD, Gianluca Garulli, MD, Walter Siquini, MD, Stefano D’Ugo, MD, PhD, FEBS, FACS, Stefano Scabini, MD, Marco Caricato, MD, FACS, Giusto Pignata, MD, Andrea Liverani, MD, Roberto Campagnacci, MD, Pierluigi Marini, MD, Ugo Elmore, MD, Francesco Corcione, MD, Roberto Santoro, MD, Massimo Carlini, MD, FACS, Antonio Giuliani, MD, Mario Sorrentino, MD, Giovanni Ferrari, MD, Gianandrea Baldazzi, MD, Alberto Di Leo, MD, Augusto Verzelli, MD, Giuseppe Sica, MD, Stefano Rausei, MD, Davide Cavaliere, MD, Gian Luca Baiocchi, MD, FACS, Marco Milone, MD, Giovanni Ciaccio, MD, Giovanni Domenico Tebala, MD, FACS, FRCS, Marco Scatizzi, MD, Luigi Boni, MD, FACS, Stefano Mancini, MD, Mario Guerrieri, MD, Roberto Persiani, MD, Andrea Lucchi, MD, FACS, Dario Parini, MD, Antonino Spinelli, MD, Michele Genna, MD, Vincenzo Bottino, MD, Andrea Coratti, MD, Dario Scala, MD, Andrea Muratore, MD, Maurizio Pavanello, MD, Umberto Rivolta, MD, Micaela Piccoli, MD, FACS, Carlo Talarico, MD, Alessandro Carrara, MD, Stefano Guadagni, MD, Mauro Totis, MD, Franco Roviello, MD, Alessandro Anastasi, MD, Gianluca Guercioni, MD, Giuseppe Maria Ettorre, MD, Mauro Montuori, MD, Pierpaolo Mariani, MD, Nicolò de Manzini, MD, Annibale Donini, MD, Mariano Fortunato Armellino, MD, Lucio Taglietti, MD, Gabriele Anania, MD, Mariantonietta Di Cosmo, MD, Carlo Vittorio Feo, MD, Paolo Millo, MD, Corrado Pedrazzani, MD, Silvio Guerriero, MD, Andrea Costanzi, MD, Nereo Vettoretto, MD, Federico Marchesi, MD, Massimo Basti, MD, Graziano Longo, MD, Moreno Cicetti, MD, Paolo Ciano, MD, Michele Benedetti, MD, Leonardo Antonio Montemurro, MD, Maria Sole Mattei, MD, Elena Belloni, MD, Elisa Bertocchi, MD, Gaia Masini, MD, Amedeo Altamura, MD, Francesco Rubichi, MD, Francesco Giudici, MD, Fabio Cianchi, MD, Gabriele Baldini, MD, Ugo Pace, MD, Andrea Fares Bucci, MD, Antonio Sciuto, MD, Desirée Cianflocca, MD, Marco Migliore, MD, Michele Simone, MD, Marcella Lodovica Ricci, MD, Francesco Monari, MD, Alessandro Cardinali, MD, Massimo Sartelli, MD, Marcello Spampinato, MD, PhD, FEBS (HPB), Alessandra Aprile, MD, Domenico Soriero, MD, Gabriella Teresa Capolupo, MD, FACS, Jacopo Andreuccetti, MD, Ilaria Canfora, MD, Andrea Scarinci, MD, Angela Maurizi, MD, Grazia Maria Attinà, MD, Giulia Maggi, MD, Umberto Bracale, MD, Roberto Peltrini, MD, Pietro Amodio, MD, Domenico Spoletini, MD, PhD, FACS, Rosa Marcellinaro, MD, Giovanni Del Vecchio, MD, Massimo Stefanoni, MD, Carmelo Magistro, MD, Diletta Cassini, MD, Lorenzo Crepaz, MD, Andrea Budassi, MD, Bruno Sensi, MD, Silvia Tenconi, MD, Leonardo Solaini, MD, Giorgio Ercolani, MD, Sarah Molfino, MD, Giovanni Domenico De Palma, MD, Paolo Locurto, MD, Antonio Di Cintio, MD, Lorenzo Pandolfini, MD, Alessandro Falsetto, MD, Elisa Cassinotti, MD, Andrea Sagnotta, MD, PhD, Monica Ortenzi, MD, Alberto Biondi, MD, Giacomo Martorelli, MD, Maurizio De Luca, MD, Francesco Carrano, MD, Annalisa Maroli, PhD, Francesca Fior, MD, Antonio Ferronetti, MD, Giuseppe Giuliani, MD, Roberto Benigni, MD, Graziella Marino, MD, Patrizia Marsanic, MD, Nicoletta Sveva Pipitone Federico, MD, Carlo Di Marco, MD, Camillo Leonardo Bertoglio, MD, PhD, Francesca Pecchini, MD, Vincenzo Greco, MD, Michele Motter, MD, Giuseppe Tirone, MD, Marco Clementi, MD, Nicolò Tamini, MD, Riccardo Piagnerelli, MD, Giuseppe Canonico, MD, Simone Cicconi, MD, Marco Colasanti, MD, Enrico Pinotti, MD, Roberta Carminati, MD, Edoardo Osenda, MD, Luigina Graziosi, MD, Ciro De Martino, MD, Giovanna Ioia, MD, Arianna Birindelli, MD, Matteo Chiozza, MD, Daniele Zigiotto, MD, Fioralba Pindozzi, MD, Manuela Grivon, MD, Cristian Conti, MD, Lorenzo Organetti, MD, Michela Monteleone, MD, Emanuele Botteri, MD, Giorgio Dalmonte, MD, Diletta Frazzini, MD, Simone Santoni, MD, Gabriele La Gioia, MD, and Diana Giannarelli, MS, PhD

Subjects
Surgery, RD1-811
Abstract

Objective:. To evaluate the influence of enhanced recovery pathway (ERP) on patient-reported outcome measures (PROMs) and return to intended oncologic therapy (RIOT) after colorectal surgery. Background:. ERP improves early outcomes after colorectal surgery; however, little is known about its influence on PROMs and on RIOT. Methods:. Prospective multicenter enrollment of patients who underwent colorectal resection with anastomosis was performed, recording variables related to patient-, institution-, procedure-level data, adherence to the ERP, and outcomes. The primary endpoints were PROMs (administered before surgery, at discharge, and 6 to 8 weeks after surgery) and RIOT after surgery for malignancy, defined as the intended oncologic treatment according to national guidelines and disease stage, administered within 8 weeks from the index operation, evaluated through multivariate regression models. Results:. The study included 4529 patients, analyzed for PROMs, 1467 of which were analyzed for RIOT. Compared to their baseline preoperative values, all PROMs showed significant worsening at discharge and improvement at late evaluation. PROMs values at discharge and 6 to 8 weeks after surgery, adjusted through a generalized mixed regression model according to preoperative status and other variables, showed no association with ERP adherence rates. RIOT rates (overall 54.5%) were independently lower by aged > 69 years, ASA Class III, open surgery, and presence of major morbidity; conversely, they were independently higher after surgery performed in an institutional ERP center and by ERP adherence rates > median (69.2%). Conclusions:. Adherence to the ERP had no effect on PROMs, whereas it independently influenced RIOT rates after surgery for colorectal cancer.

Published
2023
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128. Development of a convolutional neural network for the identification and the measurement of the median nerve on ultrasound images acquired at carpal tunnel level

Author

Gianluca Smerilli, Edoardo Cipolletta, Gianmarco Sartini, Erica Moscioni, Mariachiara Di Cosmo, Maria Chiara Fiorentino, Sara Moccia, Emanuele Frontoni, Walter Grassi, and Emilio Filippucci

Subjects
Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Deep learning applied to ultrasound (US) can provide a feedback to the sonographer about the correct identification of scanned tissues and allows for faster and standardized measurements. The most frequently adopted parameter for US diagnosis of carpal tunnel syndrome is the increasing of the cross-sectional area (CSA) of the median nerve. Our aim was to develop a deep learning algorithm, relying on convolutional neural networks (CNNs), for the localization and segmentation of the median nerve and the automatic measurement of its CSA on US images acquired at the proximal inlet of the carpal tunnel. Methods Consecutive patients with rheumatic and musculoskeletal disorders were recruited. Transverse US images were acquired at the carpal tunnel inlet, and the CSA was manually measured. Anatomical variants were registered. The dataset consisted of 246 images (157 for training, 40 for validation, and 49 for testing) from 103 patients each associated with manual annotations of the nerve boundary. A Mask R-CNN, state-of-the-art CNN for image semantic segmentation, was trained on this dataset to accurately localize and segment the median nerve section. To evaluate the performances on the testing set, precision (Prec), recall (Rec), mean average precision (mAP), and Dice similarity coefficient (DSC) were computed. A sub-analysis excluding anatomical variants was performed. The CSA was automatically measured by the algorithm. Results The algorithm correctly identified the median nerve in 41/49 images (83.7%) and in 41/43 images (95.3%) excluding anatomical variants. The following metrics were obtained (with and without anatomical variants, respectively): Prec 0.86 ± 0.33 and 0.96 ± 0.18, Rec 0.88 ± 0.33 and 0.98 ± 0.15, mAP 0.88 ± 0.33 and 0.98 ± 0.15, and DSC 0.86 ± 0.19 and 0.88 ± 0.19. The agreement between the algorithm and the sonographer CSA measurements was excellent [ICC 0.97 (0.94–0.98)]. Conclusions The developed algorithm has shown excellent performances, especially if excluding anatomical variants. Future research should aim at expanding the US image dataset including a wider spectrum of normal anatomy and pathology. This deep learning approach has shown very high potentiality for a fully automatic support for US assessment of carpal tunnel syndrome.

Published
2022
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131. Dynamical aspects in the Quantizer-Dequantizer formalism

Author

Ciaglia, Florio M., Di Cosmo, Fabio, Ibort, Alberto, and Marmo, Giuseppe

Subjects
Quantum Physics
Abstract

The use of the quantizer-dequantizer formalism to describe the evolution of a quantum system is reconsidered. We show that it is possible to embed a manifold in the space of quantum states of a given auxiliary system by means of an appropriate quantizer-dequantizer system. If this manifold of states is invariant with respect to some unitary evolution, the quantizer-dequantizer system provides a classical-like realization of such dynamics, which in general is non linear. Integrability properties are also discussed. Weyl systems and generalized coherente states are used as a simple illustration of these ideas., Comment: 15 pages

Published
2017
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132. Dynamical Vector Fields on the Manifold of Quantum States

Author

Ciaglia, Florio M., Di Cosmo, Fabio, Ibort, Alberto, Laudato, Marco, and Marmo, Giuseppe

Subjects
Quantum Physics
Abstract

In this paper we shall consider the stratified manifold of quantum states and the vector fields which act on it. In particular, we show that the infinitesimal generator of the GKLS evolution is composed of a generator of unitary transformations plus a gradient vector field along with a Kraus vector field transversal to the strata defined by the involutive distribution generated by the former ones., Comment: 30 pages, 2 figures, comments are welcome

Published
2017
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133. Covariant Jacobi Brackets for Test Particles

Author

Asorey, Manuel, Ciaglia, Florio M., Di Cosmo, Fabio, Ibort, Alberto, and Marmo, Giuseppe

Subjects
Mathematical Physics
Abstract

We show that the space of observables of test particles carries a natural Jacobi structure which is manifestly invariant under the action of the Poincar\'{e} group. Poisson algebras may be obtained by imposing further requirements. A generalization of Peierls procedure is used to extend this Jacobi bracket on the space of time-like geodesics on Minkowski space-time., Comment: 13 pages Submitted to MPLA

Published
2017
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134. Differential Calculus on Manifolds with a Boundary. Applications

Author

Ciaglia, Florio Maria, Di Cosmo, Fabio, Laudato, Marco, and Marmo, Giuseppe

Subjects
Mathematical Physics, Quantum Physics
Abstract

This paper contains a set of lecture notes on manifolds with boundary and corners, with particular attention to the space of quantum states. A geometrically inspired way of dealing with these kind of manifolds is presented,and explicit examples are given in order to clearly illustrate the main ideas., Comment: 42 pages, 6 figures, accepted for publication in International Journal of Geometric Methods in Modern Physics

Published
2017
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135. Covariant Brackets for Particles and Fields

Author

Asorey, Manuel, Ciaglia, Florio M., Di Cosmo, Fabio, and Ibort, Alberto

Subjects
Mathematical Physics
Abstract

A geometrical approach to the covariant formulation of the dynamics of relativistic systems is introduced. A realization of Peierls brackets by means of a bivector field over the space of solutions of the Euler-Lagrange equations of a variational principle is presented. The method is illustrated with some relevant examples., Comment: 14 pages

Published
2017
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136. Monotone metric tensors in quantum information geometry.

Author

Ciaglia, F. M., Di Cosmo, F., Di Nocera, F., and Vitale, P.

Subjects
*METRIC geometry, *QUANTUM states, *GEOMETRIC quantization, *DISTRIBUTION (Probability theory)
Abstract

In this paper, we review some geometrical aspects pertaining to the world of monotone quantum metrics in finite dimensions. Particular emphasis is given to an unfolded perspective for quantum states that is built out of the spectral theorem and is naturally suited to investigate the comparison with the classical case of probability distributions. [ABSTRACT FROM AUTHOR]

Published
2024
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145. Nitrogen Removal from Ink-Jet Textile Printing Wastewater by Autotrophic Biological Process: First Results at Lab and Pilot Scale

Author

Bellandi, Giacomo, Di Cosmo, Roberto, Turolla, Andrea, Bellucci, Micol, Visigalli, Simone, Menin, Glauco, Bargna, Martina, Bergna, Giovanni, Canziani, Roberto, Förstner, Ulrich, Series Editor, Rulkens, Wim H., Series Editor, Salomons, Wim, Series Editor, Ksibi, Mohamed, editor, Ghorbal, Achraf, editor, Chakraborty, Sudip, editor, Chaminé, Helder I., editor, Barbieri, Maurizio, editor, Guerriero, Giulia, editor, Hentati, Olfa, editor, Negm, Abdelazim, editor, Lehmann, Anthony, editor, Römbke, Jörg, editor, Costa Duarte, Armando, editor, Xoplaki, Elena, editor, Khélifi, Nabil, editor, Colinet, Gilles, editor, Miguel Dias, João, editor, Gargouri, Imed, editor, Van Hullebusch, Eric D., editor, Sánchez Cabrero, Benigno, editor, Ferlisi, Settimio, editor, Tizaoui, Chedly, editor, Kallel, Amjad, editor, Rtimi, Sami, editor, Panda, Sandeep, editor, Michaud, Philippe, editor, Sahu, Jaya Narayana, editor, Seffen, Mongi, editor, and Naddeo, Vincenzo, editor

Published
2021
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146. Towards a Better Understanding of Vulnerability in Pedestrian-Vehicle Collision

Author

D’Apuzzo, Mauro, Santilli, Daniela, Evangelisti, Azzurra, Di Cosmo, Luca, Nicolosi, Vittorio, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Gervasi, Osvaldo, editor, Murgante, Beniamino, editor, Misra, Sanjay, editor, Garau, Chiara, editor, Blečić, Ivan, editor, Taniar, David, editor, Apduhan, Bernady O., editor, Rocha, Ana Maria A. C., editor, Tarantino, Eufemia, editor, and Torre, Carmelo Maria, editor

Published
2021
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147. Development of an Augmented Reality System Based on Marker Tracking for Robotic Assisted Minimally Invasive Spine Surgery

Author

Villani, Francesca Pia, Di Cosmo, Mariachiara, Simonetti, Álvaro Bertelsen, Frontoni, Emanuele, Moccia, Sara, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Del Bimbo, Alberto, editor, Cucchiara, Rita, editor, Sclaroff, Stan, editor, Farinella, Giovanni Maria, editor, Mei, Tao, editor, Bertini, Marco, editor, Escalante, Hugo Jair, editor, and Vezzani, Roberto, editor

Published
2021
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148. SCIENCE IN SILENCE

Author

Büntgen, Ulf, Krusic, Paul J., and Di Cosmo, Nicola

Published
2021

149. Patient-Reported Outcomes and Return to Intended Oncologic Therapy After Colorectal Enhanced Recovery Pathway: The iCral3 Prospective Study

Author

Catarci, Marco, Ruffo, Giacomo, Viola, Massimo Giuseppe, Ficari, Ferdinando, Delrio, Paolo, Pirozzi, Felice, Borghi, Felice, De Luca, Raffaele, Patriti, Alberto, Garulli, Gianluca, Siquini, Walter, D’Ugo, Stefano, Scabini, Stefano, Caricato, Marco, Pignata, Giusto, Liverani, Andrea, Campagnacci, Roberto, Marini, Pierluigi, Elmore, Ugo, Corcione, Francesco, Santoro, Roberto, Carlini, Massimo, Giuliani, Antonio, Sorrentino, Mario, Ferrari, Giovanni, Baldazzi, Gianandrea, Di Leo, Alberto, Verzelli, Augusto, Sica, Giuseppe, Rausei, Stefano, Cavaliere, Davide, Baiocchi, Gian Luca, Milone, Marco, Ciaccio, Giovanni, Tebala, Giovanni Domenico, Scatizzi, Marco, Boni, Luigi, Mancini, Stefano, Guerrieri, Mario, Persiani, Roberto, Lucchi, Andrea, Parini, Dario, Spinelli, Antonino, Genna, Michele, Bottino, Vincenzo, Coratti, Andrea, Scala, Dario, Muratore, Andrea, Pavanello, Maurizio, Rivolta, Umberto, Piccoli, Micaela, Talarico, Carlo, Carrara, Alessandro, Guadagni, Stefano, Totis, Mauro, Roviello, Franco, Anastasi, Alessandro, Guercioni, Gianluca, Maria Ettorre, Giuseppe, Montuori, Mauro, Mariani, Pierpaolo, de Manzini, Nicolò, Donini, Annibale, Armellino, Mariano Fortunato, Taglietti, Lucio, Anania, Gabriele, Di Cosmo, Mariantonietta, Feo, Carlo Vittorio, Millo, Paolo, Pedrazzani, Corrado, Guerriero, Silvio, Costanzi, Andrea, Vettoretto, Nereo, Marchesi, Federico, Basti, Massimo, Longo, Graziano, Cicetti, Moreno, Ciano, Paolo, Benedetti, Michele, Montemurro, Leonardo Antonio, Mattei, Maria Sole, Belloni, Elena, Bertocchi, Elisa, Masini, Gaia, Altamura, Amedeo, Rubichi, Francesco, Giudici, Francesco, Cianchi, Fabio, Baldini, Gabriele, Pace, Ugo, Bucci, Andrea Fares, Sciuto, Antonio, Cianflocca, Desirée, Migliore, Marco, Simone, Michele, Ricci, Marcella Lodovica, Monari, Francesco, Cardinali, Alessandro, Sartelli, Massimo, Spampinato, Marcello, Aprile, Alessandra, Soriero, Domenico, Capolupo, Gabriella Teresa, Andreuccetti, Jacopo, Canfora, Ilaria, Scarinci, Andrea, Maurizi, Angela, Attinà, Grazia Maria, Maggi, Giulia, Bracale, Umberto, Peltrini, Roberto, Amodio, Pietro, Spoletini, Domenico, Marcellinaro, Rosa, Del Vecchio, Giovanni, Stefanoni, Massimo, Magistro, Carmelo, Cassini, Diletta, Crepaz, Lorenzo, Budassi, Andrea, Sensi, Bruno, Tenconi, Silvia, Solaini, Leonardo, Ercolani, Giorgio, Molfino, Sarah, De Palma, Giovanni Domenico, Locurto, Paolo, Di Cintio, Antonio, Pandolfini, Lorenzo, Falsetto, Alessandro, Cassinotti, Elisa, Sagnotta, Andrea, Ortenzi, Monica, Biondi, Alberto, Martorelli, Giacomo, De Luca, Maurizio, Carrano, Francesco, Maroli, Annalisa, Fior, Francesca, Ferronetti, Antonio, Giuliani, Giuseppe, Benigni, Roberto, Marino, Graziella, Marsanic, Patrizia, Pipitone Federico, Nicoletta Sveva, Di Marco, Carlo, Bertoglio, Camillo Leonardo, Pecchini, Francesca, Greco, Vincenzo, Motter, Michele, Tirone, Giuseppe, Clementi, Marco, Tamini, Nicolò, Piagnerelli, Riccardo, Canonico, Giuseppe, Cicconi, Simone, Colasanti, Marco, Pinotti, Enrico, Carminati, Roberta, Osenda, Edoardo, Graziosi, Luigina, De Martino, Ciro, Ioia, Giovanna, Birindelli, Arianna, Chiozza, Matteo, Zigiotto, Daniele, Pindozzi, Fioralba, Grivon, Manuela, Conti, Cristian, Organetti, Lorenzo, Monteleone, Michela, Botteri, Emanuele, Dalmonte, Giorgio, Frazzini, Diletta, Santoni, Simone, La Gioia, Gabriele, and Giannarelli, Diana

Published
2023
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