101. Depth profiling of laser-heated chromophores in biological tissues by pulsed photothermal radiometry.
- Author
-
Milner, TE, Goodman, DM, Tanenbaum, BS, and Nelson, JS
- Subjects
Communications Engineering ,Engineering ,Electronics ,Sensors and Digital Hardware ,Absorption ,Algorithms ,Blood Vessels ,Dermatologic Surgical Procedures ,Hemoglobins ,Hot Temperature ,Humans ,Laser Therapy ,Melanins ,Radiometry ,Skin ,Skin Physiological Phenomena ,CONSTRAINED CONJUGATE GRADIENTS ,ILL-POSED PROBLEM ,INFRARED RADIOMETRY ,LASER SURGERY ,NONNEGATIVE ,SINGULAR-VALUE DECOMPOSITION ,Optical Physics ,Electrical and Electronic Engineering ,Opthalmology and Optometry ,Optics ,Communications engineering ,Electronics ,sensors and digital hardware - Abstract
A solution method is proposed to the inverse problem of determining the unknown initial temperature distribution in a laser-exposed test material from measurements provided by infrared radiometry. A Fredholm integral equation of the first kind is derived that relates the temporal evolution of the infrared signal amplitude to the unknown initial temperature distribution in the exposed test material. The singular-value decomposition is used to demonstrate the severely ill-posed nature of the derived inverse problem. Three inversion methods are used to estimate solutions for the initial temperature distribution. A nonnegatively constrained conjugate-gradient algorithm using early termination is found superior to unconstrained inversion methods and is applied to image the depth of laser-heated chromophores in human skin.
- Published
- 1995