364 results on '"Zuercher, William J."'
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102. Progress towards a public chemogenomic set for protein kinases and a call for contributions
103. Light-dependent decomposition of FICZ, an endogenous ligand of the aryl hydrocarbon receptor
104. Abstract 1117: Triple negative breast cancer patient-derived xenografts as a translational model for discovery of novel therapeutic targets
105. A trust approach for sharing research reagents
106. High-throughput screening of a GlaxoSmithKline protein kinase inhibitor set identifies an inhibitor of human cytomegalovirus replication that prevents CREB and histone H3 post-translational modification
107. Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine seriesElectronic supplementary information (ESI) available: Figures that summarize previously reported data, biological assay methods and curves, and spectral characterization data. See DOI: 10.1039/d0md00292e
108. Identifying the Target of an Antiparasitic Compound in ToxoplasmaUsing Thermal Proteome Profiling
109. Design and Analysis of the 4‐Anilinoquin(az)oline Kinase Inhibition Profiles of GAK/SLK/STK10 Using Quantitative Structure‐Activity Relationships.
110. Progress towards a public chemogenomic set for protein kinases and a call for contributions
111. Development of Narrow Spectrum ATP-competitive Kinase Inhibitors as Probes for BIKE and AAK1
112. Abstract 684: Targeting an unconventional kinase-invasion axis in breast cancer metastasis
113. EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen
114. Identification of Small Molecule Inhibitors That Block the Toxoplasma gondii Rhoptry Kinase ROP18
115. Discovery of Novel Small Molecules that Activate Satellite Cell Proliferation and Enhance Repair of Damaged Muscle
116. The Intersection of Structural and Chemical Biology - An Essential Synergy
117. Erratum: Corrigendum: The promise and peril of chemical probes
118. Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase.
119. Serum and Glucocorticoid–Regulated Kinase 1 Regulates Neutrophil Clearance during Inflammation Resolution
120. Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays
121. A public-private partnership to unlock the untargeted kinome
122. Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)
123. GSK4112, a Small Molecule Chemical Probe for the Cell Biology of the Nuclear Heme Receptor Rev-erbα
124. Discovery of Tertiary Sulfonamides as Potent Liver X Receptor Antagonists
125. Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor
126. Structure-Guided Design of N-Phenyl Tertiary Amines as Transrepression-Selective Liver X Receptor Modulators with Anti-Inflammatory Activity
127. On the Intractability of Estrogen-Related Receptor α as a Target for Activation by Small Molecules
128. Structure‐Guided Synthesis of Tamoxifen Analogues with Improved Selectivity for the Orphan ERRγ.
129. Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRγ
130. Identification and Structure−Activity Relationship of Phenolic Acyl Hydrazones as Selective Agonists for the Estrogen-Related Orphan Nuclear Receptors ERRβ and ERRγ
131. New Synthetic Approaches to Estrogen Receptor Modulators: Imidazo[1,2-a]pyridines.
132. ChemInform Abstract: An Efficient, General Asymmetric Synthesis of Carbocyclic Nucleosides: Application of an Asymmetric Aldol/Ring-Closing Metathesis Strategy.
133. Probing the Reactivity of Solid Supports via Hammett Relationships
134. Solid-Phase Synthesis of Carbocyclic Nucleosides
135. Tandem Ring Opening−Ring Closing Metathesis of Cyclic Olefins
136. New synthetic approaches to estrogen receptor modulators: imidazo[1,2- a]pyridines
137. Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast cancer cells.
138. Chemical Probes for Understudied Kinases: Challenges and Opportunities
139. Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold
140. In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds.
141. Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor.
142. CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.
143. Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes
144. Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations
145. Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca 2+ Signaling
146. A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA
147. Quinazoline-Based Antivirulence Compounds Selectively Target SalmonellaPhoP/PhoQ Signal Transduction System
148. RIOK2: straddling the kinase/ATPase line
149. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop
150. Structure-activity relationship of dihydropyridines for rhabdomyosarcoma.
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